Mr Bingyang Zhang

Higher Degree by Research Candidate

HDR Student

School of Chemical Engineering and Advanced Materials

Faculty of Engineering, Computer and Mathematical Sciences

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During last decades, cancers are regarded as the hottest research topic. Various approaches to treat cancers have been broadly investigated. The prevention of cancers could be a better strategy than the treatment of cancers. The safety of vaccines is always the first concern in the application of cancer vaccines. Sub-unit vaccines, as a safe vaccine form, has been widely studied. However, its relatively low immune response efficiency is the main barrier limiting its development. The aim of our project is to develop a site-specific conjugated sub-unit vaccine system with high immune response efficiency to prevent desired diseases including liver cancers and prostate cancers. Designed epitopes targeting liver cancers and prostate cancers will be fused to two promising virus-like-particles (VLPs) including Hepatitis B core VLP to form novel preventive vaccines. The recombinant vaccines will be purified through chromatography and the characterizations will be evaluated. The novel recombinant VLP-based sub-unit vaccines are expected to perform safe and effective immune response to prevent liver cancers and prostate cancers.

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Journals

Year	Citation
2021	Zhang, Y., Liu, Y., Zhang, B., Yin, S., Li, X., Zhao, D., . . . Su, Z. (2021). In vitro preparation of uniform and nucleic acid free hepatitis B core particles through an optimized disassembly-purification-reassembly process. Protein Expression and Purification, 178, 105747. DOI
2020	Zhang, Y., Yin, S., Zhang, B., Bi, J., Liu, Y., & Su, Z. (2020). HBc-based virus-like particle assembly from inclusion bodies using 2-methyl-2, 4-pentanediol. Process Biochemistry, 89, 233-237. DOI Scopus1
2020	Tung, T. T., Rastin, H., Zhang, B., Bi, J., Hassan, K., & Losic, D. (2020). 3D printing of cell-laden electroconductive bioink for tissue engineering application. Journal of Materials Chemistry B, 8(27), 5862-5976. DOI Scopus6 WoS5
2020	Rastin, H., Zhang, B., Mazinani, A., Hassan, K., Bi, J., Tung, T. T., & Losic, D. (2020). 3D bioprinting of cell-laden electroconductive MXene nanocomposite bioinks. Nanoscale, 12(30), 16069-16080. DOI Scopus7 WoS5
2018	Zheng, P., Zhang, B., Jin, B., Guan, W., Bai, B., & Dai, S. (2018). Synergistic enhancement in antibacterial activity of core/shell/shell SiO₂/ZnO/Ag₃PO₄ nanoparticles. ChemNanoMat, 4(9), 972-981. DOI Scopus4 WoS5
2017	Zhang, B., Zhang, H., Dai, S., & Bi, J. (2017). Cell-penetrating peptide-labelled smart polymers for enhanced gene delivery. Engineering in Life Sciences, 17(2), 193-203. DOI Scopus3 WoS1

Position: HDR Student
Phone: 83131536
Email: bingyang.zhang@adelaide.edu.au
Campus: North Terrace
Building: Engineering North, floor 1
Room: 1 26
Org Unit: School of Chemical Engineering and Advanced Materials

Mr Bingyang Zhang

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