Mr Bingyang Zhang
HDR Student
School of Chemical Engineering and Advanced Materials
Faculty of Sciences, Engineering and Technology
During last decades, cancers are regarded as the hottest research topic. Various approaches to treat cancers have been broadly investigated. The prevention of cancers could be a better strategy than the treatment of cancers. The safety of vaccines is always the first concern in the application of cancer vaccines. Sub-unit vaccines, as a safe vaccine form, has been widely studied. However, its relatively low immune response efficiency is the main barrier limiting its development. The aim of our project is to develop a site-specific conjugated sub-unit vaccine system with high immune response efficiency to prevent desired diseases including liver cancers and prostate cancers. Designed epitopes targeting liver cancers and prostate cancers will be fused to two promising virus-like-particles (VLPs) including Hepatitis B core VLP to form novel preventive vaccines. The recombinant vaccines will be purified through chromatography and the characterizations will be evaluated. The novel recombinant VLP-based sub-unit vaccines are expected to perform safe and effective immune response to prevent liver cancers and prostate cancers.
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Journals
Year Citation 2021 Qu, Y., Wang, L., Yin, S., Zhang, B., Jiao, Y., Sun, Y., . . . Bi, J. (2021). Stability of Engineered Ferritin Nanovaccines Investigated by Combined Molecular Simulation and Experiments. J Phys Chem B, 125(15), 3830-3842.
Scopus12021 Yin, S., Wang, Y., Zhang, B., Qu, Y., Liu, Y., Dai, S., . . . Bi, J. (2021). Engineered Human Heavy-Chain Ferritin with Half-Life Extension and Tumor Targeting by PAS and RGDK Peptide Functionalization. Pharmaceutics, 13(4), 521.
Scopus3 WoS2 Europe PMC22021 Zhang, B., Yin, S., Wang, Y., Su, Z., & Bi, J. (2021). Cost-effective purification process development for chimeric hepatitis B core (HBc) virus-like particles assisted by molecular dynamic simulation. Engineering in Life Sciences, 21(6), 438-452.
Scopus1 WoS12021 Yin, S., Zhang, B., Lin, J., Liu, Y., Su, Z., & Bi, J. (2021). Development of purification process for dual-function recombinant human heavy-chain ferritin by the investigation of genetic modification impact on conformation. Engineering in Life Sciences, 21(10), 630-642.
Scopus2 WoS2 Europe PMC22021 Qu, Y., Zhang, B., Wang, Y., Yin, S., Pederick, J. L., Bruning, J. B., . . . Bi, J. (2021). Immunogenicity study of engineered ferritins with C- and N-terminus insertion of Epstein-Barr nuclear antigen 1 epitope. Vaccine, 39(34), 4830-4841.
Scopus12021 Qu, Y., Zhang, B., Wang, Y., Yin, S., Sun, Y., Middelberg, A., & Bi, J. (2021). Immunogenicity and Vaccine Efficacy Boosted by Engineering Human Heavy Chain Ferritin and Chimeric Hepatitis B Virus Core Nanoparticles. ACS Applied Bio Materials, 4(9), 7147-7156.
2021 Yin, S., Liu, Y., Dai, S., Zhang, B., Qu, Y., Zhang, Y., . . . Bi, J. (2021). Mechanism Study of Thermally Induced Anti-Tumor Drug Loading to Engineered Human Heavy-Chain Ferritin Nanocages Aided by Computational Analysis.. Biosensors (Basel), 11(11), 444.
2020 Zhang, Y., Yin, S., Zhang, B., Bi, J., Liu, Y., & Su, Z. (2020). HBc-based virus-like particle assembly from inclusion bodies using 2-methyl-2, 4-pentanediol. Process Biochemistry, 89, 233-237.
Scopus3 WoS32020 Tung, T. T., Rastin, H., Zhang, B., Bi, J., Hassan, K., & Losic, D. (2020). 3D printing of cell-laden electroconductive bioink for tissue engineering application. Journal of Materials Chemistry B, 8(27), 5862-5976.
Scopus31 WoS29 Europe PMC122020 Rastin, H., Zhang, B., Mazinani, A., Hassan, K., Bi, J., Tung, T. T., & Losic, D. (2020). 3D bioprinting of cell-laden electroconductive MXene nanocomposite bioinks. Nanoscale, 12(30), 16069-16080.
Scopus43 WoS40 Europe PMC132020 Zhang, Y., Liu, Y., Zhang, B., Yin, S., Li, X., Zhao, D., . . . Su, Z. (2020). In vitro preparation of uniform and nucleic acid free hepatitis B core particles through an optimized disassembly-purification-reassembly process.. Protein Expr Purif, 178, 1-7.
Scopus3 WoS2 Europe PMC12018 Zheng, P., Zhang, B., Jin, B., Guan, W., Bai, B., & Dai, S. (2018). Synergistic enhancement in antibacterial activity of core/shell/shell SiO₂/ZnO/Ag₃PO₄ nanoparticles. ChemNanoMat, 4(9), 972-981.
Scopus8 WoS72017 Zhang, B., Zhang, H., Dai, S., & Bi, J. (2017). Cell-penetrating peptide-labelled smart polymers for enhanced gene delivery. Engineering in Life Sciences, 17(2), 193-203.
Scopus4 WoS4
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