Higher Degree by Research Candidate
School of Chemical Engineering and Advanced Materials
Faculty of Engineering, Computer and Mathematical Sciences
During last decades, cancers are regarded as the hottest research topic. Various approaches to treat cancers have been broadly investigated. The prevention of cancers could be a better strategy than the treatment of cancers. The safety of vaccines is always the first concern in the application of cancer vaccines. Sub-unit vaccines, as a safe vaccine form, has been widely studied. However, its relatively low immune response efficiency is the main barrier limiting its development. The aim of our project is to develop a site-specific conjugated sub-unit vaccine system with high immune response efficiency to prevent desired diseases including liver cancers and prostate cancers. Designed epitopes targeting liver cancers and prostate cancers will be fused to two promising virus-like-particles (VLPs) including Hepatitis B core VLP to form novel preventive vaccines. The recombinant vaccines will be purified through chromatography and the characterizations will be evaluated. The novel recombinant VLP-based sub-unit vaccines are expected to perform safe and effective immune response to prevent liver cancers and prostate cancers.
Year Citation 2020 Zhang, Y., Yin, S., Zhang, B., Bi, J., Liu, Y., & Su, Z. (2020). HBc-based virus-like particle assembly from inclusion bodies using 2-methyl-2, 4-pentanediol. Process Biochemistry, 89, 233-237.
2020 Tung, T., Rastin, H., Zhang, B., Bi, J., Hassan, K., & Losic, D. (2020). 3D Printing of Cell-Laden Electroconductive Bioink for Tissue Engineering Application. Journal of Materials Chemistry B.
2018 Zheng, P., Zhang, B., Jin, B., Guan, W., Bai, B., & Dai, S. (2018). Synergistic enhancement in antibacterial activity of core/shell/shell SiO₂/ZnO/Ag₃PO₄ nanoparticles. ChemNanoMat, 4(9), 972-981.
DOI Scopus3 WoS4
2017 Zhang, B., Zhang, H., Dai, S., & Bi, J. (2017). Cell-penetrating peptide-labelled smart polymers for enhanced gene delivery. Engineering in Life Sciences, 17(2), 193-203.
DOI Scopus2 WoS1
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