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Dr Bill Panagopoulos

Bill Panagopoulos
THRF Early Career Research Fellow
Adelaide Medical School
Faculty of Health and Medical Sciences

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External Profiles

Dr Bill Panagopoulos

Eligible to supervise Masters and PhD (as Co-Supervisor) — email supervisor to discuss availability.

My career spans more than ten years of research experience within private and academic sectors focusing on cancer cell biology and tissue growth and repair. I am very passionate about cancer research and strive to identify new therapeutic strategies to combat metastatic disease. My primary research interest lies within the role of stromal cells within the tumour microenvironment on cancer growth and metastasis. This interest developed early on in my career but wasn't until my PhD (completed in 2016) where I became fascinated with targeting the stroma with novel therapeutic strategies as a treatment for breast cancer.  My PhD identified for the first time a causative role for peroxidase enzymes in cancer development and metastasis. This discovery has resulted in 3 first author publications, a patent application, and collaboration with a pharmaceutical company assessing novel peroxidase inhibitors as a potential therapeutic agents in the treatment/prevention of breast cancer. 

Appointments

Date Position Institution name
2017 Postdoctoral Research Fellow The University of Adelaide
2011 - 2016 Research Associate The University of Adelaide
2010 - 2011 Research Assistant SA Pathology
2009 - 2010 Study Coordinator VivoPharm
2008 - 2009 Research Assistant VivoPharm
2006 - 2008 Research Assistant TGR BioSciences
2004 - 2006 Medical Scientist Gribbles Pathology/Healthscope
2003 - 2004 Medical Scientist SA Health/Women's and Children's Hospital

Language Competencies

Language Competency
English Can read, write, speak, understand spoken and peer review
Greek, Modern (1453-) Can read, write, speak and understand spoken

Education

Date Institution name Country Title
2013 - 2016 The University of Adelaide Australia PhD
1999 - 2002 The University of South Australia Australia Bachelor of Medical and Pharmaceutical Biotechonolgy

Certifications

Date Title Institution name Country
Epigeum: Supervising Doctoral Studies The University of Adelaide

Research Interests

Journals

Year Citation
2017 Leach, D., Panagopoulos, V., Nash, C., Bevan, C., Thomson, A., Selth, L., & Buchanan, G. (2017). Cell-lineage specificity and role of AP-1 in the prostate fibroblast androgen receptor cistrome. Molecular and Cellular Endocrinology, 439(C), 261-272.
DOI Scopus7 WoS3 Europe PMC6
2017 Panagopoulos, V., Liapis, V., Zinonos, I., Hay, S., Leach, D., Ingman, W., . . . Evdokiou, A. (2017). Peroxidase enzymes inhibit osteoclast differentiation and bone resorption. Molecular and Cellular Endocrinology, 440(C), 8-15.
DOI Scopus1 WoS2
2017 Zysk, A., DeNichilo, M., Panagopoulos, V., Zinonos, I., Liapis, V., Hay, S., . . . Evdokiou, A. (2017). Adoptive transfer of ex vivo expanded Vγ9Vδ2 T cells in combination with zoledronic acid inhibits cancer growth and limits osteolysis in a murine model of osteolytic breast cancer. Cancer Letters, 386, 141-150.
DOI Scopus3 WoS3 Europe PMC3
2017 Panagopoulos, V., Leach, D., Zinonos, I., Ponomarev, V., Licari, G., Liapis, V., . . . Evdokiou, A. (2017). Inflammatory peroxidases promote breast cancer progression in mice via regulation of the tumour microenvironment. International Journal of Oncology, 50(4), 1191-1200.
DOI Scopus2 WoS2 Europe PMC1
2017 Wang, Y., Zinonos, I., Zysk, A., Panagopoulos, V., Kaur, G., Santos, A., . . . Evdokiou, A. (2017). In vivo toxicological assessment of electrochemically engineered anodic alumina nanotubes: a study of biodistribution, subcutaneous implantation and intravenous injection. Journal of Materials Chemistry B, 5(13), 2511-2523.
DOI
2017 Liapis, V., Zysk, A., DeNichilo, M., Zinonos, I., Hay, S., Panagopoulos, V., . . . Evdokiou, A. (2017). Anticancer efficacy of the hypoxia-activated prodrug evofosfamide is enhanced in combination with proapoptotic receptor agonists against osteosarcoma. Cancer Medicine, 6(9), 2164-2176.
DOI Scopus1 WoS1 Europe PMC1
2016 DeNichilo, M., Shoubridge, A., Panagopoulos, V., Liapis, V., Zysk, A., Zinonos, I., . . . Evdokiou, A. (2016). Peroxidase enzymes regulate collagen biosynthesis and matrix mineralization by cultured human osteoblasts. Calcified Tissue International, 98(3), 294-305.
DOI Scopus2 WoS2 Europe PMC2
2016 Liapis, V., Zinonos, I., Labrinidis, A., Hay, S., Ponomarev, V., Panagopoulos, V., . . . Evdokiou, A. (2016). Anticancer efficacy of the hypoxia-activated prodrug evofosfamide (TH-302) in osteolytic breast cancer murine models. Cancer Medicine, 5(3), 534-545.
DOI Scopus7 WoS6 Europe PMC7
2015 Panagopoulos, V., Zinonos, I., Leach, D., Hay, S., Liapis, V., Zysk, A., . . . Evdokiou, A. (2015). Uncovering a new role for peroxidase enzymes as drivers of angiogenesis. The International Journal of Biochemistry and Cell Biology, 68, 128-138.
DOI Scopus7 WoS6 Europe PMC4
2015 Liapis, V., Labrinidis, A., Zinonos, I., Hay, S., Ponomarev, V., Panagopoulos, V., . . . Evdokiou, A. (2015). Hypoxia-activated pro-drug TH-302 exhibits potent tumor suppressive activity and cooperates with chemotherapy against osteosarcoma. Cancer Letters, 357(1), 160-169.
DOI Scopus18 WoS16 Europe PMC14
2015 DeNichilo, M., Panagopoulos, V., Rayner, T., Borowicz, R., Greenwood, J., & Evdokiou, A. (2015). Peroxidase enzymes regulate collagen extracellular matrix biosynthesis. American Journal of Pathology, 185(5), 1372-1384.
DOI Scopus7 WoS7 Europe PMC4
2014 Zinonos, I., Labrinidis, A., Liapis, V., Hay, S., Panagopoulos, V., Denichilo, M., . . . Evdokiou, A. (2014). Doxorubicin overcomes resistance to drozitumab by antagonizing inhibitor of apoptosis proteins (IAPS). Anticancer Research, 34(12), 7007-7020.
Scopus2 WoS2 Europe PMC2
2014 Zinonos, I., Luo, K., Labrinidis, A., Liapis, V., Hay, S., Panagopoulos, V., . . . Evdokiou, A. (2014). Pharmacologic inhibition of bone resorption prevents cancer-induced osteolysis but enhances soft tissue metastasis in a mouse model of osteolytic breast cancer. International Journal of Oncology, 45(2), 532-540.
DOI Scopus13 WoS13 Europe PMC9
2008 Borowicz, R., Panagopoulos, V., Greenwood, J., DeNichilo, M., & Rayner, T. (2008). Discovery of a novel modulator of extracellular matrix with the potential to promote wound healing. WOUND REPAIR AND REGENERATION, 16(2), A42.

Conference Papers

Year Citation
2015 Panagopoulos, V., Zinonos, I., Liapis, V., Hay, S., Ingman, W., Iasiello, M. P., . . . Evdokiou, A. (2015). Uncovering a new role for peroxidases in breast cancer development and metastasis. In CLINICAL & EXPERIMENTAL METASTASIS Vol. 32 (pp. 227-228). SPRINGER.

Conference Items

Year Citation
2017 Liapis, V., Labrinidis, A., Zinonos, I., Hay, S., Ponomarev, V., Panagopoulos, V., . . . Evdokiou, A. (2017). Anticancer efficacy of the hypoxia-activated pro-drug evofosfamide in prcelinIcal osteosarcoma murine models. Poster session presented at the meeting of INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. SPANDIDOS PUBL LTD.
2017 Liapis, V., Zinonos, I., Labrinidis, A., Hay, S., Ponomarev, V., Panagopoulos, V., . . . Evdokiou, A. (2017). The hypoxia activated pro-drug evofosfamide exhibits tumour suppressive activity and synergy with chemotherapy against primary and metastatic breast cancers. Poster session presented at the meeting of INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. SPANDIDOS PUBL LTD.
2017 Shoubridge, A., Panagopoulos, V., Anderson, P., Field, J., Saifzadeh, S., Steck, R., . . . Evdokiou, A. (2017). Soybean Peroxidase Possesses Osteogenic Activity to Accelerate Bone Regeneration In Vivo. Poster session presented at the meeting of JOURNAL OF BONE AND MINERAL RESEARCH. Denver, CO: WILEY.

Teaching Interests:

2013-2016                   Mentored 1 Honours student and 3 PhD students

2013-2014                   Supervised a University of Adelaide summer student

Current Higher Degree by Research Supervision (University of Adelaide)

Date Role Research Topic Program Degree Type Student Load Student Name
2017 Co-Supervisor Fibrosis, Cancer and the Pre-Metastatic Niche: Implications for Peroxidases Doctor of Philosophy Doctorate Full Time Mr Christopher Difelice
2017 Co-Supervisor Injectable fibrin as a biocompatible polymer scaffold that mediates probagates cytotoxic (TCell) Immunogenicity to Cancer Master of Philosophy (Surgery) Master Full Time Mr Panos Panayiotou
2016 Co-Supervisor The Role of Peroxidase Enzymes in Fracture Repair of Healthy and Osteoporotic Bone Doctor of Philosophy Doctorate Full Time Miss Alexandra Jayne Shoubridge

Committee Memberships

Date Role Committee Institution Country
2017 - ongoing Representative BHI Strategic Research Directions Group Basil Hetzel Institute Australia
2017 - ongoing Member Australian Society for Medical Research (ASMR) State Committee
2015 - 2016 Representative BHI Management Committee Basil Hetzel Insitute
Position
THRF Early Career Research Fellow
Phone
82226173
Campus
Queen Elizabeth Hospital
Building
QEH- Basil Hetzel Institute, floor 1
Org Unit
Surgical Specialties

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