Professor William Hague

Professor Bill HagueMade in China, produced in Hong Kong and brought up in the UK, Bill Hague came to Adelaide, South Australia in 1988 as a Consultant and Research Fellow/Honorary Senior Lecturer, first at The Queen Elizabeth Hospital and later moving to the Women's and Children's Hospital in 1990. After undergraduate training at Trinity College, Cambridge and St Thomas' Hospital, London, he had completed his postgraduate training in Cambridge, Sheffield and London, in particular with Professor Michael de Swiet at Queen Charlotte's Hospital, London, and with Professor Howard Jacobs at the Middlesex Hospital, London, with specialist qualifications in both Internal Medicine and Obstetrics and Gynaecology, and with a Cambridge MD in Familial Aspects of Polycystic Ovaries. The obstetric medicine service he helped to build up at TQEH, and later at the W&CH, was recognised around Australia and overseas for its quality and commitment. His clinical service work, teaching and research achievements were recognised by The University of Adelaide with a promotion to full Professor in November 2011. He founded the Obstetric Medicine Group of Australasia (OMGA) in 1992, and in 2009 became the first Honorary Member of the Society of Obstetric Medicine of Australia and New Zealand (SOMANZ), following the amalgamation of OMGA and the Australasian Society for the Study of Hypertension in Pregnancy (ASSHP), of which he is a former President. His contributions include the first robust demonstration of the efficacy and safety of metformin in women with gestational diabetes (the MiG Study) in collaboration with Dr Janet Rowan from Auckland, published in the NEJM in 2008, and leading the writing of the SOMANZ consensus statement for the diagnosis and management of Intrahepatic cholestasis of pregnancy (ICP) in 2023. He has also been involved in the Australasian Maternity Outcomes Surveillance System (AMOSS).He retired from his position as Senior Consultant Physician in Obstetric Medicine, Women & Children's Hospital, Adelaide, in 2021, but continues as a Research Leader in Obstetric Medicine at the Robinson Research Institute, The University of Adelaide.Other Appointments◾Former Chair of the South Australian Maternal Mortality Committee◾Previous Member of the Australian National Advisory Committee on Maternal Mortality and Serious Morbidity◾South Australian Coordinator, Australasian Maternity Outcomes Surveillance System (AMOSS)◾Former Regional Secretary Oceania Region, International Christian Medical and Dental Association◾Former Oceania Desk-holder, Partners in International Medical Education◾Past National Chairman of the Christian Medical and Dental Fellowship of Australia◾Past Member of Advisory Council for South Australian Stillbirth and Neonatal Death Support GroupQualifications◾2001 FRCP (London) ◾1993 FRCOG◾1988 MD (Cantab)◾1987 Certificate of Accreditation (JCHMT), Endocrinology and Obstetric Medicine◾1983 MRCOG◾1978 MRCP(UK)◾1975 MA (Cantab)◾1975 MB, BChir (Cantab)◾1972 BA (Cantab)Research Interests◾The benefits of the diagnosis and management of early gestational diabetes in women at risk : the TOBOGM RCT◾Follow-up of offspring of women with eGDM in the TOBOGM RCT ; The TOMTHUMB study◾The comparison of pregnancy and health economic outcomes in women diagnosed as gestational diabetes (GDM) using ADIPS-1998 criteria compared with those diagnosed using IADPSG criteria◾The comparison of pregnancy and health economic outcomes in women diagnosed as GDM randomised to "tight" and "very tight" glucose control◾The prevalence of MODY genotypes in South Australian women with GDM◾Metformin as an alternative to insulin in the management of women with GDM : the MiG RCT◾Follow-up of offspring of women with GDM treated with metformin or insulin ; The MiG-TOFU study◾Metformin in the prevention of recurrent GDM◾Metformin effects on insulin resistance in women with GDM◾Metformin effects on vitamin B12 metabolism in women with GDM◾Pharmacokinetics of metformin in women with GDM◾Metformin for women who are obese during pregnancy for improving maternal and infant outcomes : the GROW RCT◾Postpartum SMS reminders to women who have had GDM to test for type 2 diabetes: a randomised controlled trial: The DIAMIND study ◾The place of low molecular weight heparin in the prevention of recurrent utero-placental thrombosis and associated diseases in women with thrombophilia : the TIPPS and FRUIT RCTs◾The role of genetic and acquired thrombophilia, including polymorphisms of methylenetetrahydrofolate reductase, activated protein C resistance, prothrombin gene mutation, protein S deficiency, hyperhomocysteinaemia and antiphospholipid antibodies in the aetiology of pre-eclampsia, placental abruption, intra-uterine growth restriction and recurrent miscarriage◾The role of genetic thrombophilia, including polymorphisms of methylenetetrahydrofolate reductase, activated protein C resistance and the prothrombin gene mutation in the aetiology of cerebral palsy◾The relationship of pre-eclampsia to the subsequent development of vascular disease and its link to hyperhomocysteinaemia◾The effect of folate supplementation on the prevention of pre-eclampsia: the Folic Acid Clinical Trial (FACT) RCT◾Follow-up of offspring of women treated with high dose folic acid compared with normal controls : the FACT for CHILD study◾Investigations in the Folic Acid Clinical Trial - the INFACT study◾The effect of folate supplementation on the prevention of recurrent pre-eclampsia in women with hyperhomocysteinaemia : the HOPE study◾Longitudinal study of genome stability in the mother, fetus, neonate and child in relation to folate and B12 status◾The role of common polymorphisms in the methylenetetrahydrofolate reductase, methionine synthase and thymidylate synthase genes as determinants of genome stability in mothers, fetuses, neonates and children◾The diagnosis and treatment of severe early onset intrahepatic cholestasis of pregnancy (ICP) : the TURRIFIC RCT◾The prevalence of ICP in South Australia◾Treatment of obstetric cholestasis: the PITCH RCT◾Genetic mechanisms of bile transporters◾The aetiology of microvesicular hepatic steatosis and its relationship to clinical outcomes in women and sheep◾The total Bile Acid Comparison and Harmonisation (BACH) project: a sub-study of the TURRIFIC RCT◾The potential value of extra-cellular vesicles to assess cholestasis in pregnancy◾The exploration of the gut microbiome in the aetiology of ICP◾The long-term outcome of the offspring of women who have had ICP using linkage studies◾The control of hypertension in pregnancy: the CHIPS RCT◾Follow-up of the offspring of the CHIPS study: the CHIPS-CHILD study◾The Australasian Maternity Outcomes Surveillance System (AMOSS)