Benjamin Kile

Professor Benjamin Kile

Executive Dean

Health and Medical Sciences Faculty Office

Faculty of Health and Medical Sciences

Ben is Executive Dean of the Faculty of Health and Medical Sciences at the University of Adelaide. His PhD was conducted at the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia, under the supervision of Professors Warren Alexander and Douglas Hilton. Graduating in 2001, Ben pursued postdoctoral studies with Professor Monica Justice at Baylor College of Medicine, Houston, USA. In 2004 he returned to the Walter and Eliza Hall Institute, joining the faculty in 2005, and being appointed an independent laboratory head in 2008. After jointly leading the institute's ACRF Chemical Biology Division from 2014-2017, Ben took up the position of Head, Department of Anatomy and Developmental Biology, within the Biomedicine Discovery Institute at Monash University. In October 2019 he moved to the University of Adelaide.

The Kile lab's research has focused primarily on the molecular regulation of blood cell formation and function, at steady state, and in disease settings such as inflammation and leukemia. We have a deep interest in the role programmed cell death pathways play in these processes, and how the cell death machinery mediates the response to pathophysiological insults such as cancer chemotherapy. Our work has contributed to understanding the survival of platelets – the tiny cells that mediate blood clotting – and informed the clinical development of a new class of cancer drugs called the BH3 mimetics. We have identified critical roles for the cell death machinery in suppressing innate immune signalling, suggesting new therapeutic approaches to the treatment of viral infections and cancer.

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  • Journals
    Year Citation
    2020 Pépin, G., De Nardo, D., Rootes, C., Ullah, T., Al-Asmari, S., Balka, K., . . . Gantier, M. (2020). Connexin-dependent transfer of cgamp to phagocytes modulates antiviral responses. mBio, 11(1).
    DOI
    2020 Denorme, F., Manne, B., Portier, I., Eustes, A., Kosaka, Y., Kile, B., . . . Campbell, R. (2020). Platelet necrosis mediates ischemic stroke outcome in mice. Blood, 135(6), 429-440.
    DOI Scopus1
    2020 Balka, K. R., Louis, C., Saunders, T. L., Smith, A. M., Calleja, D. J., D'Silva, D. B., . . . De Nardo, D. (2020). TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells.. Cell reports, 31(1), 107492.
    DOI
    2019 Strassel, C., Magiera, M. M., Dupuis, A., Batzenschlager, M., Hovasse, A., Pleines, I., . . . Lanza, F. (2019). An essential role for α4A-tubulin in platelet biogenesis.. Life science alliance, 2(1).
    DOI Scopus4 Europe PMC1
    2019 Hildebrand, J., Kauppi, M., Majewski, I., Liu, Z., Cox, A., Miyake, S., . . . Silke, J. (2019). Missense mutations in the MLKL ‘brace’ region lead to lethal neonatal inflammation in mice and are present in high frequency in humans.
    DOI
    2019 Walkley, C. R., & Kile, B. T. (2019). Cell death following the loss of ADAR1 mediated A-to-I RNA editing is not effected by the intrinsic apoptosis pathway. Cell Death and Disease, 10(12), 913.
    DOI
    2019 Iacobucci, I., Wen, J., Meggendorfer, M., Choi, J. K., Shi, L., Pounds, S. B., . . . Mullighan, C. G. (2019). Genomic subtyping and therapeutic targeting of acute erythroleukemia. Nature genetics, 51(4), 694-704.
    DOI Scopus8 WoS7 Europe PMC3
    2019 Chiu, S., Orive, S., Moon, M., Saw, J., Ellis, S., Kile, B., . . . Curtis, D. (2019). Shared roles for Scl and Lyl1 in murine platelet production and function. Blood, 134(10), 826-835.
    DOI Scopus1 WoS1
    2019 Levin, J., & Kile, B. (2019). Acknowledgements: the Levin/Kile rule. Platelets, 30(2), 280.
    DOI
    2019 Jiao, Y., Davis, J., Rautela, J., Carrington, E., Ludford-Menting, M., Goh, W., . . . Huntington, N. (2019). Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes. Cell Death and Differentiation, 26(8), 1516-1530.
    DOI Scopus1 WoS1 Europe PMC1
    2019 van Delft, M. F., Chappaz, S., Khakham, Y., Bui, C. T., Debrincat, M. A., Lowes, K. N., . . . Kile, B. T. (2019). A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis. Nature Chemical Biology, 15(11), 1057-1066.
    DOI Scopus1
    2018 Conway, A., Brown, F., Rank, G., Kile, B., Morton, C., Jane, S., & Curtis, D. (2018). Characterization of Tfrc-mutant mice with microcytic phenotypes. Blood Advances, 2(15), 1914-1922.
    DOI
    2018 McArthur, K., Whitehead, L., Heddleston, J., Li, L., Padman, B., Oorschot, V., . . . Kile, B. (2018). BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis. Science, 359(6378), 883-+.
    DOI Scopus76 WoS67 Europe PMC30
    2018 Tye, H., Yu, C., Simms, L., de Zoete, M., Kim, M., Zakrzewski, M., . . . Masters, S. (2018). NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease. Nature Communications, 9(1), 3728-1-3728-11.
    DOI Scopus15 WoS10 Europe PMC5
    2018 Pleines, I., Lebois, M., Gangatirkar, P., Au, A., Lane, R., Henley, K., . . . Josefsson, E. (2018). Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion. Blood, 132(2), 197-209.
    DOI Scopus4 WoS4 Europe PMC1
    2018 McArthur, K., Chappaz, S., & Kile, B. (2018). Apoptosis in megakaryocytes and platelets: the life and death of a lineage. Blood, 131(6), 605-610.
    DOI Scopus21 WoS18 Europe PMC9
    2018 Lindqvist, L., Frank, D., McArthur, K., Dite, T., Lazarou, M., Oakhill, J., . . . Vaux, D. (2018). Autophagy induced during apoptosis degrades mitochondria and inhibits type i interferon secretion. Cell Death and Differentiation, 25(4), 782-794.
    DOI Scopus10 WoS11 Europe PMC4
    2018 Rabbolini, D., Chun, Y., Latimer, M., Kunishima, S., Fixter, K., Valecha, B., . . . Morel-Kopp, M. (2018). Diagnosis and treatment of MYH9-RD in an Australasian cohort with thrombocytopenia. Platelets, 29(8), 793-800.
    DOI Scopus3 WoS8
    2018 Vince, J., De Nardo, D., Gao, W., Vince, A., Hall, C., McArthur, K., . . . Lawlor, K. (2018). The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation. Cell Reports, 25(9), 2339-2353.e4.
    DOI Scopus28 WoS23 Europe PMC8
    2018 McArthur, K., & Kile, B. (2018). Apoptotic caspases: Multiple or mistaken identities?. Trends in Cell Biology, 28(6), 475-493.
    DOI Scopus27 WoS21 Europe PMC6
    2017 Lorenz, V., Ramsey, H., Liu, Z., Italiano, J., Hoffmeister, K., Bihorel, S., . . . Ferrer-Marin, F. (2017). Developmental Stage-Specific Manifestations of Absent TPO/c-MPL Signalling in Newborn Mice. Thrombosis and Haemostasis, 117(12), 2322-2333.
    DOI Scopus4 WoS2 Europe PMC2
    2017 Conway, A., Brown, F., Fullinfaw, R., Kile, B., Jane, S., & Curtis, D. (2017). A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen. DMM Disease Models and Mechanisms, 10(8), 1005-1013.
    DOI Scopus2 WoS3 Europe PMC3
    2017 Brown, F., Collett, M., Tremblay, C., Rank, G., De Camilli, P., Booth, C., . . . Curtis, D. (2017). Loss of Dynamin 2 GTPase function results in microcytic anaemia. British Journal of Haematology, 178(4), 616-628.
    DOI Scopus2 WoS2 Europe PMC2
    2017 Yuan, Y., Alwis, I., Wu, M., Kaplan, Z., Ashworth, K., Bark, D., . . . Jackson, S. (2017). Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia. Science Translational Medicine, 9(409), eaam5861-1-eaam5861-14.
    DOI Scopus19 WoS14 Europe PMC4
    2017 Au, A., Lebois, M., Sim, S., Cannon, P., Corbin, J., Gangatirkar, P., . . . Josefsson, E. (2017). Altered B-lymphopoiesis in mice with deregulated thrombopoietin signaling. Scientific Reports, 7(1), 14953-1-14953-10.
    DOI
    2017 Thirant, C., Ignacimouttou, C., Lopez, C., Diop, M., Le Mouël, L., Thiollier, C., . . . Mercher, T. (2017). ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia. Cancer Cell, 31(3), 452-465.
    DOI Scopus21 WoS20 Europe PMC11
    2017 Viant, C., Guia, S., Hennessy, R., Rautela, J., Pham, K., Bernat, C., . . . Huntington, N. (2017). Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival. Journal of Experimental Medicine, 214(2), 491-510.
    DOI Scopus23 WoS20 Europe PMC12
    2017 Pleines, I., Woods, J., Chappaz, S., Kew, V., Foad, N., Ballester-Beltrán, J., . . . Kile, B. (2017). Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia. Journal of Clinical Investigation, 127(3), 814-829.
    DOI Scopus18 WoS15 Europe PMC10
    2016 Murphy, A., Kraakman, M., Kammoun, H., Dragoljevic, D., Lee, M., Lawlor, K., . . . Masters, S. (2016). IL-18 production from the NLRP1 inflammasome prevents obesity and metabolic syndrome. Cell Metabolism, 23(1), 155-164.
    DOI Scopus66 WoS66 Europe PMC48
    2016 Rowley, J., Chappaz, S., Corduan, A., Chong, M., Campbell, R., Khoury, A., . . . Weyrich, A. (2016). Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets. Blood, 127(14), 1743-1751.
    DOI Scopus42 WoS40 Europe PMC24
    2016 Keniry, A., Gearing, L., Jansz, N., Liu, J., Holik, A., Hickey, P., . . . Blewitt, M. (2016). Setdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing. Epigenetics & Chromatin, 9(1), 16=1-16-20.
    DOI Scopus24 WoS24 Europe PMC21
    2016 Lebois, M., Dowling, M., Gangatirkar, P., Hodgkin, P., Kile, B., Alexander, W., & Josefsson, E. (2016). Regulation of platelet lifespan in the presence and absence of thrombopoietin signaling. Journal of Thrombosis and Haemostasis, 14(9), 1882-1887.
    DOI Scopus8 WoS7 Europe PMC6
    2016 Delbridge, A., Chappaz, S., Ritchie, M., Kile, B., Strasser, A., & Grabow, S. (2016). Loss of PUMA (BBC3) does not prevent thrombocytopenia caused by the loss of BCL-XL (BCL2L1). British Journal of Haematology, 174(6), 962-969.
    DOI Scopus3 WoS2 Europe PMC1
    2016 Karve, I., Zhang, M., Habgood, M., Frugier, T., Brody, K., Sashindranath, M., . . . Crack, P. (2016). Ablation of type-1 IFN signaling in hematopoietic cells confers protection following traumatic brain injury. eNeuro, 3(1), 89-93.
    DOI Scopus14 Europe PMC6
    2016 Lee, E., Grabow, S., Chappaz, S., Dewson, G., Hockings, C., Kluck, R., . . . Fairlie, W. (2016). Physiological restraint of Bak by Bcl-x⌊ is essential for cell survival. Genes and Development, 30(10), 1240-1250.
    DOI Scopus19 WoS16 Europe PMC14
    2015 Carpinelli, M., Kruse, E., Arhatari, B., Debrincat, M., Ogier, J., Bories, J., . . . Burt, R. (2015). Mice haploinsufficient for Ets1 and Fli1 display middle ear abnormalities and model aspects of Jacobsen syndrome. American Journal of Pathology, 185(7), 1867-1876.
    DOI Scopus10 WoS7 Europe PMC4
    2015 Debrincat, M., Pleines, I., Lebois, M., Lane, R., Holmes, M., Corbin, J., . . . Josefsson, E. (2015). BCL-2 is dispensable for thrombopoiesis and platelet survival. Cell Death and Disease, 6(4), e1721-1-e1721-8.
    DOI Scopus28 WoS23 Europe PMC17
    2015 Schevzov, G., Kee, A., Wang, B., Sequeira, V., Hook, J., Coombes, J., . . . Gunning, P. (2015). Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments. Molecular Biology of the Cell, 26(13), 2475-2490.
    DOI Scopus29 WoS26 Europe PMC19
    2015 Chirn, G., Rahman, R., Sytnikova, Y., Matts, J., Zeng, M., Gerlach, D., . . . Lau, N. (2015). Conserved piRNA expression from a distinct set of piRNA cluster loci in eutherian mammals. PLoS Genetics, 11(11), e1005652-1-e1005652-26.
    DOI Scopus28 WoS25 Europe PMC20
    2015 Brown, F., Conway, A., Cerruti, L., Collinge, J., McLean, C., Wiley, J., . . . Curtis, D. (2015). Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model. Blood, 126(26), 2863-2870.
    DOI Scopus9 WoS9 Europe PMC9
    2015 Kedzierski, L., Clemens, E., Bird, N., Kile, B., Belz, G., Nicola, N., . . . Nicholson, S. (2015). SOCS4 is dispensable for an efficient recall response to influenza despite being required for primary immunity. Immunology and Cell Biology, 93(10), 909-913.
    DOI Scopus5 WoS5 Europe PMC2
    2015 Zhang, J., Farley, A., Nicholson, S., Willson, T., Zugaro, L., Simpson, R., . . . Baca, M. (2015). Correction: The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation (Proceedings of the National Academy of Sciences of the United States of America (1999) 96, 5 (2071-2076) DOI: 10.1073/pnas.96.5.2071). Proceedings of the National Academy of Sciences of the United States of America, 112(22), E2979.
    DOI Scopus5 WoS5 Europe PMC1
    2015 White, M., & Kile, B. (2015). Stressed mitochondria sound the alarm. Immunology and Cell Biology, 93(5), 427-428.
    DOI Scopus3 WoS4 Europe PMC2
    2015 Kile, B. (2015). Aging platelets stimulate TPO production. Nature Medicine, 21(1), 11-12.
    DOI Scopus2 WoS2 Europe PMC2
    2015 Cottle, D., Ursino, G., Ip, S., Jones, L., Ditommaso, T., Hacking, D., . . . Smyth, I. (2015). Fetal inhibition of inflammation improves disease phenotypes in harlequin ichthyosis. Human Molecular Genetics, 24(2), 436-449.
    DOI Scopus13 WoS12 Europe PMC9
    2015 Kim, M., Chae, J., Park, Y., De Nardo, D., Stirzaker, R., Ko, H., . . . Masters, S. (2015). Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β. Journal of Experimental Medicine, 212(6), 927-938.
    DOI Scopus67 WoS65 Europe PMC51
    2014 Josefsson, E., Burnett, D., Lebois, M., Debrincat, M., White, M., Henley, K., . . . Kile, B. (2014). Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways. Nature Communications, 5(1), 3455-1-3455-14.
    DOI Scopus41 WoS37 Europe PMC27
    2014 White, M., McArthur, K., Metcalf, D., Lane, R., Cambier, J., Herold, M., . . . Kile, B. (2014). Apoptotic caspases suppress mtDNA-induced STING-mediated type i IFN production. Cell, 159(7), 1549-1562.
    DOI Scopus265 WoS256 Europe PMC170
    2014 Kedzierski, L., Linossi, E., Kolesnik, T., Day, E., Bird, N., Kile, B., . . . Nicholson, S. (2014). Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection. PLoS Pathogens, 10(5), e1004134-1-e1004134-13.
    DOI Scopus26 WoS26 Europe PMC20
    2014 Allam, R., Lawlor, K., Yu, E., Mildenhall, A., Moujalled, D., Lewis, R., . . . Vince, J. (2014). Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming. EMBO Reports, 15(9), 982-990.
    DOI Scopus106 WoS98 Europe PMC74
    2014 Liu, Z., Hoffmeister, K., Hu, Z., Mager, D., Ait-Oudhia, S., Debrincat, M., . . . Sola-Visner, M. (2014). Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan. Blood, 123(22), 3381-3389.
    DOI Scopus35 WoS29 Europe PMC24
    2014 Kile, B. (2014). The role of apoptosis in megakaryocytes and platelets. British Journal of Haematology, 165(2), 217-226.
    DOI Scopus61 WoS54 Europe PMC38
    2014 Vandenberg, C., Josefsson, E., Campbell, K., James, C., Lawlor, K., Kile, B., & Cory, S. (2014). Loss of Bak enhances lymphocytosis but does not ameliorate thrombocytopaenia in BCL-2 transgenic mice. Cell Death and Differentiation, 21(5), 676-684.
    DOI Scopus11 WoS10 Europe PMC8
    2014 Mitchell, W., Pinheiro, M., Boulad, N., Kaplan, D., Edison, M., Psaila, B., . . . Bussel, J. (2014). Effect of thrombopoietin receptor agonists on the apoptotic profile of platelets in patients with chronic immune thrombocytopenia. American Journal of Hematology, 89(12), E228-E234.
    DOI Scopus16 WoS16 Europe PMC11
    2014 Potts, K., Sargeant, T., Markham, J., Shi, W., Biben, C., Josefsson, E., . . . Taoudi, S. (2014). A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo. Blood, 124(17), 2725-2729.
    DOI Scopus25 WoS20 Europe PMC15
    2014 Ogier, J., Carpinelli, M., Arhatari, B., Symons, R., Kile, B., & Burt, R. (2014). CHD7 deficiency in " Looper", a new mouse model of CHARGE syndrome, results in ossicle malformation, otosclerosis and hearing impairment. PLoS ONE, 9(5), e97559-1-e97559-11.
    DOI Scopus12 WoS12 Europe PMC7
    2014 Gerlic, M., Croker, B., Cengia, L., Moayeri, M., Kile, B., & Masters, S. (2014). NLRP1a expression in srebp-1a-deficient mice. Cell Metabolism, 19(3), 345-346.
    DOI Scopus3 WoS3 Europe PMC2
    2014 Carpinelli, M., Voss, A., Manning, M., Perera, A., Cooray, A., Kile, B., & Burt, R. (2014). A new mouse model of Canavan leukodystrophy displays hearing impairment due to central nervous system dysmyelination. Disease Models and Mechanisms, 7(6), 649-657.
    DOI Scopus7 WoS7 Europe PMC6
    2013 Tang, J., Carmichael, C., Shi, W., Metcalf, D., Ng, A., Hyland, C., . . . Alexander, W. (2013). Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia. Proceedings of the National Academy of Sciences, 110(15), 6091-6096.
    DOI Scopus13 WoS13 Europe PMC11
    2013 Carpinelli, M., Manning, M., Kile, B., & Rachel, A. (2013). Two ENU-induced alleles of Atp2b2 cause deafness in mice. PLoS ONE, 8(6), e67479-1-e67479-8.
    DOI Scopus8 WoS9 Europe PMC8
    2013 Downes, C., Wong, C., Henley, K., Guio-Aguilar, P., Zhang, M., Ates, R., . . . Crack, P. (2013). MyD88 is a critical regulator of hematopoietic cell-mediated neuroprotection seen after stroke. PLoS ONE, 8(3), e57948.
    DOI Scopus16 WoS16 Europe PMC12
    2013 Fu, Y., Mukhamedova, N., Ip, S., D'Souza, W., Henley, K., Ditommaso, T., . . . Sviridov, D. (2013). ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis. Cell Metabolism, 18(2), 225-238.
    DOI Scopus37 WoS37 Europe PMC23
    2013 Dowling, M., Josefsson, E., Henley, K., Kile, B., & Hodgkin, P. (2013). A model for studying the hemostatic consumption or destruction of platelets. PLoS ONE, 8(3), e57783-1-e57783-14.
    DOI Scopus6 WoS4 Europe PMC5
    2013 Putoczki, T., Thiem, S., Loving, A., Busuttil, R., Wilson, N., Ziegler, P., . . . Ernst, M. (2013). Interleukin-11 is the dominant Il-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically. Cancer Cell, 24(2), 257-271.
    DOI Scopus196 WoS189 Europe PMC137
    2013 Carpinelli, M., Manning, M., Kile, B., & Burt, R. (2013). Erratum: Two ENU-induced alleles of atp2b2 cause deafness in mice. PLoS ONE, 8(7).
    DOI Scopus2
    2013 Takiguchi, M., Dow, L., Prier, J., Carmichael, C., Kile, B., Turner, S., . . . Dickins, R. (2013). Variability of inducible expression across the hematopoietic system of tetracycline transactivator transgenic mice. PLoS ONE, 8(1), e54009-1-e54009-10.
    DOI Scopus16 WoS16 Europe PMC14
    2013 Brown, F., Scott, N., Rank, G., Collinge, J., Vadolas, J., Vickaryous, N., . . . Curtis, D. (2013). ENU mutagenesis identifies the first mouse mutants reproducing human β-thalassemia at the genomic level. Blood Cells, Molecules, and Diseases, 50(2), 86-92.
    DOI Scopus12 WoS12 Europe PMC12
    2013 Fleming, P., Kvansakul, M., Voigt, V., Kile, B., Kluck, R., Huang, D., . . . Andoniou, C. (2013). MCMV-mediated inhibition of the pro-apoptotic bak protein is required for optimal in vivo replication. PLoS Pathogens, 9(2), e1003192-1-e1003192-12.
    DOI Scopus13 WoS12 Europe PMC11
    2013 Mason, K., Lin, A., Robb, L., Josefsson, E., Henley, K., Gray, D., . . . O'Reilly, L. (2013). Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease. Proceedings of the National Academy of Sciences of the United States of America, 110(7), 2599-2604.
    DOI Scopus32 WoS30 Europe PMC26
    2013 Qiao, J., Schoenwaelder, S., Mason, K., Tran, H., Davis, A., Kaplan, Z., . . . Gardiner, E. (2013). Low adhesion receptor levels on circulating platelets in patients with lymphoproliferative diseases before receiving Navitoclax (ABT-263). Blood, 121(8), 1479-1481.
    DOI Scopus14 WoS14 Europe PMC9
    2012 White, M., Schoenwaelder, S., Josefsson, E., Jarman, K., Henley, K., James, C., . . . Kile, B. (2012). Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function. Blood, 119(18), 4283-4290.
    DOI Scopus54 WoS47 Europe PMC41
    2012 Masters, S., Gerlic, M., Metcalf, D., Preston, S., Pellegrini, M., O'Donnell, J., . . . Croker, B. (2012). NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells. Immunity, 37(6), 1009-1023.
    DOI Scopus141 WoS144 Europe PMC111
    2012 Lindqvist, L., Vikström, I., Chambers, J., McArthur, K., Ann Anderson, M., Henley, K., . . . Huang, D. (2012). Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor. Cell Death and Disease, 3(10), 9 pages.
    DOI Scopus30 WoS29 Europe PMC22
    2012 Zhang, J., Czabotar, P., Policheni, A., Caminschi, I., San Wan, S., Kitsoulis, S., . . . Lahoud, M. (2012). The Dendritic Cell Receptor Clec9A Binds Damaged Cells via Exposed Actin Filaments. Immunity, 36(4), 646-657.
    DOI Scopus171 WoS160 Europe PMC129
    2012 Kile, B. (2012). The spreading influence of platelet HDACs. Blood, 120(20), 4118-4119.
    DOI
    2012 Carmichael, C., Metcalf, D., Henley, K., Kruse, E., Di Rago, L., Mifsud, S., . . . Kile, B. (2012). Hematopoietic overexpression of the transcription factor Erg induces lymphoid and erythro-megakaryocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America, 109(38), 15437-15442.
    DOI Scopus26 WoS25 Europe PMC20
    2012 Verhagen, A., De Graaf, C., Baldwin, T., Goradia, A., Collinge, J., Kile, B., . . . Hilton, D. (2012). Reduced lymphocyte longevity and homeostatic proliferation in lamin B receptor-deficient mice results in profound and progressive lymphopenia. Journal of Immunology, 188(1), 122-134.
    DOI Scopus6 WoS7 Europe PMC6
    2012 Debrincat, M., Josefsson, E., James, C., Henley, K., Ellis, S., Lebois, M., . . . Kile, B. (2012). Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival. Blood, 119(24), 5850-5858.
    DOI Scopus47 WoS42 Europe PMC35
    2012 Kraemer, B., Campbell, R., Schwertz, H., Franks, Z., De Abreu, A., Grundler, K., . . . Weyrich, A. (2012). Bacteria differentially induce degradation of Bcl-x<inf>L</inf>, a survival protein, by human platelets. Blood, 120(25), 5014-5020.
    DOI Scopus34 WoS32 Europe PMC24
    2012 Josefsson, E., White, M., Dowling, M., & Kile, B. (2012). Platelet life span and apoptosis. Methods in Molecular Biology, 788, 59-71.
    DOI Scopus20 Europe PMC16
    2012 Carpinelli, M. R., Burt, R. A., & Kile, B. T. (2012). Genetic Modifier Screens in Mice.. Current protocols in mouse biology, 2(1), 75-87.
    DOI Europe PMC1
    2012 Kauppi, M., Hilton, A., Metcalf, D., Ng, A., Hyland, C., Collinge, J., . . . Alexander, W. (2012). Thrombocytopenia and erythrocytosis in mice with a mutation in the gene encoding the hemoglobin β minor chain. Proceedings of the National Academy of Sciences of the United States of America, 109(2), 576-581.
    DOI Scopus1 WoS1 Europe PMC1
    2011 Fairfield, H., Gilbert, G., Barter, M., Corrigan, R., Curtain, M., Ding, Y., . . . Reinholdt, L. (2011). Mutation discovery in mice by whole exome sequencing. Genome Biology, 12(9), 12 pages.
    DOI Scopus79 WoS71 Europe PMC63
    2011 Schoenwaelder, S., Jarman, K., Gardiner, E., Hua, M., Qiao, J., White, M., . . . Jackson, S. (2011). Bcl-x<inf>L</inf>-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets. Blood, 118(6), 1663-1674.
    DOI Scopus137 WoS127 Europe PMC109
    2011 Josefsson, E., James, C., Henley, K., Debrincat, M., Rogers, K., Dowling, M., . . . Kile, B. (2011). Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets. Journal of Experimental Medicine, 208(10), 2017-2031.
    DOI Scopus109 WoS99 Europe PMC84
    2011 Nguyen, N., Maxwell, M., Ooms, L., Davies, E., Hilton, A., Collinge, J., . . . Curtis, D. (2011). An ENU-induced mouse mutant of SHIP1 reveals a critical role of the stem cell isoform for suppression of macrophage activation. Blood, 117(20), 5362-5371.
    DOI Scopus14 WoS13 Europe PMC9
    2011 Ng, A., Loughran, S., Metcalf, D., Hyland, C., De Graaf, C., Hu, Y., . . . Alexander, W. (2011). Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice. Blood, 118(9), 2454-2461.
    DOI Scopus30 WoS27 Europe PMC25
    2011 Bishton, M., Harrison, S., Martin, B., McLaughlin, N., James, C., Josefsson, E., . . . Johnstone, R. (2011). Deciphering the molecular and biologic processes that mediate histone deacetylase inhibitor - Induced thrombocytopenia. Blood, 117(13), 3658-3668.
    DOI Scopus101 WoS92 Europe PMC70
    2011 Taoudi, S., Bee, T., Hilton, A., Knezevic, K., Scott, J., Willson, T., . . . Hilton, D. (2011). ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification. Genes and Development, 25(3), 251-262.
    DOI Scopus60 WoS47 Europe PMC46
    2010 Kelly, P., White, M., Goschnick, M., Fairfax, K., Tarlinton, D., Kinkel, S., . . . Strasser, A. (2010). Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development. Cell Death and Differentiation, 17(10), 1655-1664.
    DOI Scopus41 WoS37 Europe PMC31
    2010 Greig, K., De Graaf, C., Murphy, J., Carpinelli, M., Pang, S., Frampton, J., . . . Nutt, S. (2010). Critical roles for c-Myb in lymphoid priming and early B-cell development. Blood, 115(14), 2796-2805.
    DOI Scopus44 WoS43 Europe PMC39
    2010 Takiguchi, M., James, C., Josefsson, E., Carmichael, C., Premsrirut, P., Lowe, S., . . . Dickins, R. (2010). Transgenic, inducible RNAi in megakaryocytes and platelets in mice. Journal of Thrombosis and Haemostasis, 8(12), 2751-2756.
    DOI Scopus7 WoS7 Europe PMC7
    2010 Ng, A., Hyland, C., Metcalf, D., Carmichael, C., Loughran, S., Di Rago, L., . . . Alexander, W. (2010). Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome. Blood, 115(19), 3966-3969.
    DOI Scopus47 WoS39 Europe PMC36
    2010 Dowling, M., Josefsson, E., Henley, K., Hodgkin, P., & Kile, B. (2010). Platelet senescence is regulated by an internal timer, not damage inflicted by hits. Blood, 116(10), 1776-1778.
    DOI Scopus40 WoS36 Europe PMC30
    2010 White, M., & Kile, B. (2010). Apoptotic Processes in Megakaryocytes and Platelets. Seminars in Hematology, 47(3), 227-234.
    DOI Scopus33 WoS28 Europe PMC23
    2010 Cordell, P., Kile, B., Standeven, K., Josefsson, E., Pease, R., & Grant, P. (2010). Association of coagulation factor XIII-A with Golgi proteins within monocyte-macrophages: Implications for subcellular trafficking and secretion. Blood, 115(13), 2674-2681.
    DOI Scopus42 WoS40 Europe PMC34
    2009 Hilton, D., Kile, B., & Alexander, W. (2009). Mutational inhibition of c-Myb or p300 ameliorates treatment-induced thrombocytopenia. Blood, 113(22), 5599-5604.
    DOI Scopus7 WoS6 Europe PMC6
    2009 Kruse, E., Loughran, S., Baldwin, T., Josefsson, E., Ellis, S., Watson, D., . . . Kile, B. (2009). Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage. Proceedings of the National Academy of Sciences of the United States of America, 106(33), 13814-13819.
    DOI Scopus59 WoS55 Europe PMC40
    2009 Ellett, F., Kile, B., & Lieschke, G. (2009). The role of the ETS factor erg in zebrafish vasculogenesis. Mechanisms of Development, 126(3-4), 220-229.
    DOI Scopus22 WoS20 Europe PMC15
    2009 Rank, G., Sutton, R., Marshall, V., Lundie, R., Caddy, J., Romeo, T., . . . Jane, S. (2009). Novel roles for erythroid Ankyrin-1 revealed through an ENU-induced null mouse mutant. Blood, 113(14), 3352-3362.
    DOI Scopus37 WoS35 Europe PMC33
    2009 Verhagen, A., Wallace, M., Goradia, A., Jones, S., Croom, H., Metcalf, D., . . . Starr, R. (2009). A kinase-dead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency. Journal of Immunology, 182(4), 2020-2029.
    DOI Scopus14 WoS13 Europe PMC10
    2009 Schoenwaelder, S., Yuan, Y., Josefsson, E., White, M., Yao, Y., Mason, K., . . . Jackson, S. (2009). Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function. Blood, 114(3), 663-666.
    DOI Scopus188 WoS180 Europe PMC153
    2008 Smyth, I., Hacking, D., Hilton, A., Mukhamedova, N., Meikle, P., Ellis, S., . . . Hilton, D. (2008). A mouse model of harlequin ichthyosis delineates a key role for Abca12 in lipid homeostasis. PLoS Genetics, 4(9), 11 pages.
    DOI Scopus54 WoS50 Europe PMC42
    2008 Kauppi, M., Murphy, J., De Graaf, C., Hyland, C., Greig, K., Metcalf, D., . . . Alexander, W. (2008). Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl/mice. Blood, 112(8), 3148-3153.
    DOI Scopus24 WoS25 Europe PMC21
    2008 Loughran, S., Kruse, E., Hacking, D., de Graaf, C., Hyland, C., Willson, T., . . . Kile, B. (2008). The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells. Nature Immunology, 9(7), 810-819.
    DOI Scopus171 WoS158 Europe PMC143
    2008 Burt, R., Joseph, J., Milliken, S., Collinge, J., & Kile, B. (2008). Description of a novel mutation leading to MYH9-related disease. Thrombosis Research, 122(6), 861-863.
    DOI Scopus14 WoS14 Europe PMC13
    2007 Kile, B., Panopoulos, A., Stirzaker, R., Hacking, D., Tahtamouni, L., Willson, T., . . . Justice, M. (2007). Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia. Blood, 110(7), 2371-2380.
    DOI Scopus62 WoS63 Europe PMC49
    2007 Greig, K., Antonchuk, J., Metcalf, D., Morgan, P., Krebs, D., Zhang, J., . . . Kile, B. (2007). Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development. Molecular and Cellular Biology, 27(16), 5849-5859.
    DOI Scopus39 WoS38 Europe PMC32
    2007 Tucker, E., O'Donnell, K., Fuchsberger, M., Hilton, A., Metcalf, D., Greig, K., . . . Starr, R. (2007). A novel mutation in the Nfkb2 gene generates an NF-κB2 "super repressor". Journal of Immunology, 179(11), 7514-7522.
    DOI Scopus55 WoS57 Europe PMC47
    2007 Mason, K., Carpinelli, M., Fletcher, J., Collinge, J., Hilton, A., Ellis, S., . . . Kile, B. (2007). Programmed Anuclear Cell Death Delimits Platelet Life Span. Cell, 128(6), 1173-1186.
    DOI Scopus597 WoS553 Europe PMC457
    2007 Debrincat, M., Zhang, J., Willson, T., Silke, J., Connolly, L., Simpson, R., . . . Hilton, D. (2007). Ankyrin repeat and suppressors of cytokine signaling box protein Asb-9 targets creatine kinase B for degradation. Journal of Biological Chemistry, 282(7), 4728-4737.
    DOI Scopus38 WoS36 Europe PMC26
    2007 Silver, J., Hilton, D., Bahlo, M., & Kile, B. (2007). Probabilistic analysis of recessive mutagenesis screen strategies. Mammalian Genome, 18(1), 5-22.
    DOI Scopus4 WoS2 Europe PMC2
    2006 Alexander, W., Viney, E., Zhang, J., Metcalf, D., Kauppi, M., Hyland, C., . . . Hilton, D. (2006). Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene. Proceedings of the National Academy of Sciences of the United States of America, 103(44), 16442-16447.
    DOI Scopus53 WoS48 Europe PMC36
    2005 Kile, B., & Hilton, D. (2005). The art and design of genetic screens: Mouse. Nature Reviews Genetics, 6(7), 557-567.
    DOI Scopus66 WoS57 Europe PMC43
    2003 Kile, B., Hentges, K., Clark, A., Nakamura, H., Salinger, A., Liu, B., . . . Justice, M. (2003). Functional genetic analysis of mouse chromosome 11. Nature, 425(6953), 81-86.
    DOI Scopus164 WoS150 Europe PMC132
    2003 Kile, B., Mason-Garrison, C., & Justice, M. (2003). Sex and strain-related differences in the peripheral blood cell values of inbred mouse strains. Mammalian Genome, 14(1), 81-85.
    DOI Scopus28 WoS27 Europe PMC24
    2002 Kile, B., Schulman, B., Alexander, W., Nicola, N., Martin, H., & Hilton, D. (2002). The SOCS box: A tale of destruction and degradation. Trends in Biochemical Sciences, 27(5), 235-241.
    DOI Scopus327 WoS305 Europe PMC213
    2001 Kile, B., Metcalf, D., Mifsud, S., DiRago, L., Nicola, N., Hilton, D., & Alexander, W. (2001). Functional analysis of Asb-1 using genetic modification in mice. Molecular and Cellular Biology, 21(18), 6189-6197.
    DOI Scopus43 WoS40 Europe PMC31
    2001 Kile, B., & Alexander, W. (2001). The suppressors of cytokine signalling (SOCS). Cellular and Molecular Life Sciences, 58(11), 1627-1635.
    DOI Scopus128 WoS125 Europe PMC86
    2001 Kile, B., Nicola, N., & Alexander, W. (2001). Negative regulators of cytokine signaling. International Journal of Hematology, 73(3), 292-298.
    DOI Scopus57 WoS55 Europe PMC41
    2000 Kile, B., Viney, E., Willson, T., Brodnicki, T., Cancilla, M., Herlihy, A., . . . Alexander, W. (2000). Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4. Gene, 258(1-2), 31-41.
    DOI Scopus37 WoS38 Europe PMC27
    1999 Cutts, S., Fowler, K., Kile, B., Hii, L., O'Dowd, R., Hudson, D., . . . Choo, K. (1999). Defective chromosome segregation, microtubule bundling and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice. Human Molecular Genetics, 8(7), 1145-1155.
    DOI Scopus82 WoS83 Europe PMC62
    1999 Saffery, R., Irvine, D., Kile, B., Hudson, D., Cutts, S., & Choo, K. (1999). Cloning, expression, and promoter structure of a mammalian inner centromere protein (INCENP). Mammalian Genome, 10(4), 415-418.
    DOI Scopus8 WoS7 Europe PMC4
    1999 Zhang, J., Farley, A., Nicholson, S., Willson, T., Zugaro, L., Simpson, R., . . . Baca, M. (1999). The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proceedings of the National Academy of Sciences of the United States of America, 96(5), 2071-2076.
    DOI Scopus491 WoS476 Europe PMC317
    1999 Alexander, W., Starr, R., Metcalf, D., Nicholson, S., Farley, A., Elefanty, A., . . . Hilton, D. (1999). Suppressors of cytokine signaling (SOCS): Negative regulators of signal transduction. Journal of Leukocyte Biology, 66(4), 588-592.
    DOI Scopus93 WoS89 Europe PMC48
    1998 Fowler, K., Saffery, R., Kile, B., Irvine, D., Hudson, D., Trowell, H., & Choo, K. (1998). Genetic mapping of mouse centromere protein (Incenp and Cenpe) genes. Cytogenetics and Cell Genetics, 82(1-2), 67-70.
    DOI Scopus4 WoS4 Europe PMC2

  • Book Chapters
    Year Citation
    2013 Josefsson, E., Dowling, M., Lebois, M., & Kile, B. (2013). The Regulation of Platelet Life Span. In Platelets (pp. 51-65).
    DOI Scopus13
    2009 Josefsson, E., & Kile, B. (2009). Cell death in the hematopoietic system. In Essentials of Apoptosis: A Guide for Basic and Clinical Research (pp. 443-459).
    DOI Scopus2

  • Conference Papers
    Year Citation
    2009 Kile, B. (2009). The role of the intrinsic apoptosis pathway in platelet life and death. In Journal of Thrombosis and Haemostasis Vol. 7 (pp. 214-217). Boston, MD: WILEY-BLACKWELL PUBLISHING, INC.
    DOI Scopus50 WoS48 Europe PMC32

2018-2021 DHB Foundation managed by ANZ Trustees. The development of small molecule inhibitors of cell death. $800,000. CIA: BT Kile, CIB: G Lessene.

2017-2021 NHMRC Program Grant No. 1113577: Regulation of Haemopoietic and Immune Cells in Health and Disease. $19,924,985. CIA: WS Alexander, CIB: JJ Babon, CIC: MC Cook, CID: DJ Hilton, CIE: BT Kile, CIF: NA Nicola, CIG: AW Roberts, CIH: CG Vinuesa, CII: IP Wicks.

2015-2018 NHMRC Project Grant No. 1077750: The role of apoptotic caspases in regulating type I interferon production. $761,513. CIA: BT Kile, CIB: M Pellegrini.

2014-2018 NHMRC Principal Research Fellowship No. 1063008. $727,610. CI: BT Kile.

2014-2017 DHB Foundation managed by ANZ Trustees. The development of small molecule inhibitors of cell death. $650,000. CIA: BT Kile, CIB: G Lessene.

2013 Leukaemia Foundation of Australia Research Grant-in-aid. Elucidation of the mechanisms involved in the development of erythromegakaryocytic leukaemia driven by the proto-oncogene ETS-related gene ERG. $100,000. CIA: CL Carmichael, CIB: BT Kile.

2012-2016 NHMRC Program Grant No. 1016647: Molecular regulation of blood cell production and function. $17,100,000. CIA: NA Nicola, CIB: WS Alexander, CIC: DJ Hilton, CID: D Metcalf, CIE: AW Roberts, CIF: JG Zhang, CIG: SE Nicholson, CIH: BT Kile, CII: IP Wicks.

2011-2013 NHMRC Project Grant No. 1002426: Defining the role of Nlrp1 and the inflammasome in host defence and inflammatory disease. $612,561. CIA: BT Kile, CIB: B Croker, CIC: SL Masters.

2009-2011 NHMRC Project Grant No. 545906: The role of the ABCA12 transporter in epidermal lipid homeostasis and atherosclerosis. $496,250. CIA: I Smyth, CIB: D Sviridov, CIC: BT Kile.

2009-2011 NHMRC Project Grant No. 575535: Bcl-2 proteins and the regulation of the megakaryocyte lineage. $399,900. CIA: BT Kile, CIB: C James.

2009-2013 Sylvia & Charles Viertel Foundation Senior Medical Research Fellowship. $975,000. CI: BT Kile.

2008-2010 NHMRC Project Grant No. 516726: Role of the Ets family transcription factor Erg in stem cell function and leukemia development. $397,125 CIA: BT Kile.

2008-2010 NHMRC Project Grant No. 516725: The molecular regulation of platelet life span. $521,000. CIA: BT Kile, CIB: SP Jackson, CIC: AW Roberts.

2007-2011 Cancer Council of Victoria Venture Grant No. Scanning the genome for new drug targets in cancer CIA: WS Alexander, CIB: BT Kile, CIC: A Strasser. 2007-2011. $244,500.

2007-2009 NHMRC Project Grant No. 461247: The genetic control of platelet production and function. $537,000 CIA: BT Kile, CIB: WS Alexander, CIC: HH Nandurkar.

  • Position: Executive Dean
  • Phone: 83135193
  • Email: benjamin.kile@adelaide.edu.au
  • Campus: North Terrace
  • Building: Helen Mayo North, floor 3
  • Room: N3 07
  • Org Unit: Health and Medical Sciences Faculty Office
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