Professor Benjamin Kile
Executive Dean
Health and Medical Sciences Faculty Office
Faculty of Health and Medical Sciences
Ben is Executive Dean of the Faculty of Health and Medical Sciences at the University of Adelaide. His PhD was conducted at the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia, under the supervision of Professors Warren Alexander and Douglas Hilton. Graduating in 2001, Ben pursued postdoctoral studies with Professor Monica Justice at Baylor College of Medicine, Houston, USA. In 2004 he returned to the Walter and Eliza Hall Institute, joining the faculty in 2005, and being appointed an independent laboratory head in 2008. After jointly leading the institute's ACRF Chemical Biology Division from 2014-2017, Ben took up the position of Head, Department of Anatomy and Developmental Biology, within the Biomedicine Discovery Institute at Monash University. In October 2019 he moved to the University of Adelaide.
The Kile lab's research has focused primarily on the molecular regulation of blood cell formation and function, at steady state, and in disease settings such as inflammation and leukemia. We have a deep interest in the role programmed cell death pathways play in these processes, and how the cell death machinery mediates the response to pathophysiological insults such as cancer chemotherapy. Our work has contributed to understanding the survival of platelets – the tiny cells that mediate blood clotting – and informed the clinical development of a new class of cancer drugs called the BH3 mimetics. We have identified critical roles for the cell death machinery in suppressing innate immune signalling, suggesting new therapeutic approaches to the treatment of viral infections and cancer.
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Appointments
Date Position Institution name 2019 - ongoing Executive Dean Faculty of Health and Medical Sciences 2017 - 2019 Head, Department of Anatomy and Developmental Biology Monash University 2014 - 2017 Head, ACRF Chemical Biology Division Walter and Eliza Hall Institute of Medical Research 2012 - ongoing Board Member Australian Genomics Research Facility 2008 - 2013 Laboratory Head Walter and Eliza Hall Institute of Medical Research -
Education
Date Institution name Country Title 2001 University of Melbourne Australia PhD 1997 University of Melbourne Australia BSc(Hons) 1995 Monash University Australia LLB 1993 Monash University Australia BSc -
Research Interests
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Journals
Year Citation 2022 Davidson, S., Yu, C. H., Steiner, A., Ebstein, F., Baker, P. J., Jarur-Chamy, V., . . . Masters, S. L. (2022). Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24. Science Immunology, 7(68), eabi6763.
Scopus4 Europe PMC12022 Pang, E. S., Daraj, G., Balka, K. R., De Nardo, D., Macri, C., Hochrein, H., . . . O'Keeffe, M. (2022). Discordance in STING-Induced Activation and Cell Death Between Mouse and Human Dendritic Cell Populations. Frontiers in immunology, 13, 794776-1-794776-19.
2022 Salmon, J. M., Todorovski, I., Stanley, K. L., Bruedigam, C., Kearney, C. J., Martelotto, L. G., . . . Johnstone, R. W. (2022). Epigenetic activation of plasmacytoid DC drives IFNAR-dependent therapeutic differentiation of AML. Cancer Discovery, 12(6), 1560-1579.
2021 Lee, M. K. S., Kraakman, M. J., Dragoljevic, D., Hanssen, N. M. J., Flynn, M. C., Al-Sharea, A., . . . Murphy, A. J. (2021). Apoptotic ablation of platelets reduces atherosclerosis in mice with diabetes. Arteriosclerosis, Thrombosis and Vascular Biology, 41(3), 1167-1178.
Scopus3 WoS3 Europe PMC32021 Chappaz, S., Saunders, T. L., & Kile, B. T. (2021). Generation of murine bone marrow and fetal liver chimeras. Current Protocols, 1(4), e79-1-e79-20.
2021 Strassel, C., Magiera, M. M., Dupuis, A., Batzenschlager, M., Hovasse, A., Pleines, I., . . . Lanza, F. (2021). Correction: An essential role for α4A-tubulin in platelet biogenesis.. Life science alliance, 4(8), e202101132.
2021 Chappaz, S., McArthur, K., Kealy, L., Law, C. W., Tailler, M., Lane, R. M., . . . Kile, B. T. (2021). Homeostatic apoptosis prevents competition-induced atrophy in follicular B cells. Cell Reports, 36(3), 1-7.
WoS1 Europe PMC12021 Ngo, S., Oxley, E. P., Ghisi, M., Garwood, M. M., McKenzie, M. D., Mitchell, H. L., . . . Dickins, R. A. (2021). Acute myeloid leukemia maturation lineage influences residual disease and relapse following differentiation therapy. Nature Communications, 12(1), 1-14.
2020 McArthur, K., & Kile, B. T. (2020). Apoptotic mitochondria prime anti-tumour immunity. Cell death discovery, 6(1), 1-3.
2020 Pépin, G., De Nardo, D., Rootes, C. L., Ullah, T. R., Al-Asmari, S. S., Balka, K. R., . . . Gantier, M. P. (2020). Connexin-dependent transfer of cgamp to phagocytes modulates antiviral responses. mBio, 11(1), 1-6.
Scopus22 WoS21 Europe PMC152020 Denorme, F., Manne, B. K., Portier, I., Eustes, A. S., Kosaka, Y., Kile, B. T., . . . Campbell, R. A. (2020). Platelet necrosis mediates ischemic stroke outcome in mice. Blood, 135(6), 429-440.
Scopus25 WoS26 Europe PMC212020 Balka, K. R., Louis, C., Saunders, T. L., Smith, A. M., Calleja, D. J., D'Silva, D. B., . . . De Nardo, D. (2020). TBK1 and IKKε act redundantly to mediate STING-induced NF-κB responses in myeloid cells. Cell Reports, 31(1), 107492-1-107492-22.
Scopus69 WoS72 Europe PMC522020 Chappaz, S., Law, C. W., Dowling, M. R., Carey, K. T., Lane, R. M., Ngo, L. H., . . . Kile, B. T. (2020). Germline heterozygous mutations in Nxf1 perturb RNA metabolism and trigger thrombocytopenia and lymphopenia in mice. Blood Advances, 4(7), 1270-1283.
Scopus3 WoS3 Europe PMC32020 Hildebrand, J. M., Kauppi, M., Majewski, I. J., Liu, Z., Cox, A. J., Miyake, S., . . . Silke, J. (2020). A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction. Nature Communications, 11(1), 3150.
Scopus41 WoS40 Europe PMC302020 Fagnan, A., Bagger, F. O., Piqué-Borràs, M. R., Ignacimouttou, C., Caulier, A., Lopez, C. K., . . . Mercher, T. (2020). Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers. Blood, 136(6), 698-714.
Scopus15 WoS14 Europe PMC92020 Deo, P., Chow, S. H., Han, M. L., Speir, M., Huang, C., Schittenhelm, R. B., . . . Naderer, T. (2020). Mitochondrial dysfunction caused by outer membrane vesicles from Gram-negative bacteria activates intrinsic apoptosis and inflammation. Nature Microbiology, 5(11), 1418-1427.
Scopus27 WoS26 Europe PMC142020 Carmichael, C. L., Wang, J., Nguyen, T., Kolawole, O., Benyoucef, A., De Mazière, C., . . . Haigh, J. J. (2020). The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1. Blood, 136(8), 957-973.
Scopus12 WoS12 Europe PMC82020 Denorme, F., Manne, B. K., Portier, I., Petrey, A. C., Middleton, E., Kile, B. T., . . . Campbell, R. A. (2020). COVID-19 patients exhibit reduced procoagulant platelet responses. Journal of thrombosis and haemostasis : JTH, 18(11), 3067-3073.
Scopus31 WoS32 Europe PMC272020 McArthur, K., & Kile, B. T. (2020). Apoptotic mitochondria prime anti-tumour immunity. Cell Death Discovery, 6(1), 3 pages.
Scopus4 WoS4 Europe PMC32019 Strassel, C., Magiera, M. M., Dupuis, A., Batzenschlager, M., Hovasse, A., Pleines, I., . . . Lanza, F. (2019). An essential role for α4A-tubulin in platelet biogenesis. Life Science Alliance, 2(1), e201900309-1-e201900309-13.
Scopus20 Europe PMC112019 Hildebrand, J., Kauppi, M., Majewski, I., Liu, Z., Cox, A., Miyake, S., . . . Silke, J. (2019). Missense mutations in the MLKL ‘brace’ region lead to lethal neonatal inflammation in mice and are present in high frequency in humans.
2019 Walkley, C. R., & Kile, B. T. (2019). Cell death following the loss of ADAR1 mediated A-to-I RNA editing is not effected by the intrinsic apoptosis pathway. Cell Death and Disease, 10(12), 913.
Scopus6 WoS5 Europe PMC52019 Iacobucci, I., Wen, J., Meggendorfer, M., Choi, J. K., Shi, L., Pounds, S. B., . . . Mullighan, C. G. (2019). Genomic subtyping and therapeutic targeting of acute erythroleukemia. Nature genetics, 51(4), 694-704.
Scopus53 WoS58 Europe PMC332019 Chiu, S., Orive, S., Moon, M., Saw, J., Ellis, S., Kile, B., . . . Curtis, D. (2019). Shared roles for Scl and Lyl1 in murine platelet production and function. Blood, 134(10), 826-835.
Scopus7 WoS7 Europe PMC22019 Levin, J., & Kile, B. (2019). Acknowledgements: the Levin/Kile rule. Platelets, 30(2), 280.
2019 Jiao, Y., Davis, J. E., Rautela, J., Carrington, E. M., Ludford-Menting, M. J., Goh, W., . . . Huntington, N. D. (2019). Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes. Cell Death and Differentiation, 26(8), 1516-1530.
Scopus7 WoS7 Europe PMC52019 van Delft, M. F., Chappaz, S., Khakham, Y., Bui, C. T., Debrincat, M. A., Lowes, K. N., . . . Kile, B. T. (2019). A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis. Nature Chemical Biology, 15(11), 1057-1066.
Scopus15 WoS13 Europe PMC92018 McArthur, K., Whitehead, L., Heddleston, J., Li, L., Padman, B., Oorschot, V., . . . Kile, B. (2018). BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis. Science, 359(6378), 883-+.
Scopus303 WoS295 Europe PMC1922018 Tye, H., Yu, C. H., Simms, L. A., de Zoete, M. R., Kim, M. L., Zakrzewski, M., . . . Masters, S. L. (2018). NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease. Nature Communications, 9(1), 3728-1-3728-11.
Scopus47 WoS44 Europe PMC212018 Pleines, I., Lebois, M., Gangatirkar, P., Au, A., Lane, R., Henley, K., . . . Josefsson, E. (2018). Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion. Blood, 132(2), 197-209.
Scopus9 WoS9 Europe PMC42018 McArthur, K., Chappaz, S., & Kile, B. (2018). Apoptosis in megakaryocytes and platelets: the life and death of a lineage. Blood, 131(6), 605-610.
Scopus49 WoS47 Europe PMC322018 Lindqvist, L., Frank, D., McArthur, K., Dite, T., Lazarou, M., Oakhill, J., . . . Vaux, D. (2018). Autophagy induced during apoptosis degrades mitochondria and inhibits type i interferon secretion. Cell Death and Differentiation, 25(4), 782-794.
Scopus25 WoS24 Europe PMC142018 Rabbolini, D., Chun, Y., Latimer, M., Kunishima, S., Fixter, K., Valecha, B., . . . Morel-Kopp, M. (2018). Diagnosis and treatment of MYH9-RD in an Australasian cohort with thrombocytopenia. Platelets, 29(8), 793-800.
Scopus10 WoS16 Europe PMC32018 Vince, J., De Nardo, D., Gao, W., Vince, A., Hall, C., McArthur, K., . . . Lawlor, K. (2018). The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation. Cell Reports, 25(9), 2339-2353.e4.
Scopus95 WoS97 Europe PMC592018 Conway, A. J., Brown, F. C., Rank, G., Kile, B. T., Morton, C. J., Jane, S. M., & Curtis, D. J. (2018). Characterization of Tfrc-mutant mice with microcytic phenotypes. Blood Advances, 2(15), 1914-1922.
Scopus3 WoS3 Europe PMC22018 McArthur, K., & Kile, B. (2018). Apoptotic caspases: Multiple or mistaken identities?. Trends in Cell Biology, 28(6), 475-493.
Scopus63 WoS62 Europe PMC292017 Lorenz, V., Ramsey, H., Liu, Z., Italiano, J., Hoffmeister, K., Bihorel, S., . . . Ferrer-Marin, F. (2017). Developmental Stage-Specific Manifestations of Absent TPO/c-MPL Signalling in Newborn Mice. Thrombosis and Haemostasis, 117(12), 2322-2333.
Scopus11 WoS10 Europe PMC82017 Conway, A., Brown, F., Fullinfaw, R., Kile, B., Jane, S., & Curtis, D. (2017). A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen. DMM Disease Models and Mechanisms, 10(8), 1005-1013.
Scopus3 WoS3 Europe PMC32017 Brown, F., Collett, M., Tremblay, C., Rank, G., De Camilli, P., Booth, C., . . . Curtis, D. (2017). Loss of Dynamin 2 GTPase function results in microcytic anaemia. British Journal of Haematology, 178(4), 616-628.
Scopus3 WoS3 Europe PMC32017 Yuan, Y., Alwis, I., Wu, M., Kaplan, Z., Ashworth, K., Bark, D., . . . Jackson, S. (2017). Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia. Science Translational Medicine, 9(409), eaam5861-1-eaam5861-14.
Scopus38 WoS39 Europe PMC232017 Au, A., Lebois, M., Sim, S., Cannon, P., Corbin, J., Gangatirkar, P., . . . Josefsson, E. (2017). Altered B-lymphopoiesis in mice with deregulated thrombopoietin signaling. Scientific Reports, 7(1), 14953-1-14953-10.
Scopus1 WoS1 Europe PMC12017 Pleines, I., Woods, J., Chappaz, S., Kew, V., Foad, N., Ballester-Beltrán, J., . . . Kile, B. (2017). Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia. Journal of Clinical Investigation, 127(3), 814-829.
Scopus40 WoS38 Europe PMC272017 Thirant, C., Ignacimouttou, C., Lopez, C. K., Diop, M., Le Mouël, L., Thiollier, C., . . . Mercher, T. (2017). ETO2-GLIS2 hijacks transcriptional complexes to drive cellular identity and self-renewal in pediatric acute megakaryoblastic leukemia. Cancer Cell, 31(3), 452-465.
Scopus38 WoS40 Europe PMC282017 Viant, C., Guia, S., Hennessy, R., Rautela, J., Pham, K., Bernat, C., . . . Huntington, N. (2017). Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival. Journal of Experimental Medicine, 214(2), 491-510.
Scopus41 WoS39 Europe PMC332016 Murphy, A. J., Kraakman, M. J., Kammoun, H. L., Dragoljevic, D., Lee, M. K. S., Lawlor, K. E., . . . Masters, S. L. (2016). IL-18 production from the NLRP1 inflammasome prevents obesity and metabolic syndrome. Cell Metabolism, 23(1), 155-164.
Scopus101 WoS100 Europe PMC762016 Delbridge, A., Chappaz, S., Ritchie, M., Kile, B., Strasser, A., & Grabow, S. (2016). Loss of PUMA (BBC3) does not prevent thrombocytopenia caused by the loss of BCL-XL (BCL2L1). British Journal of Haematology, 174(6), 962-969.
Scopus6 WoS5 Europe PMC42016 Karve, I. P., Zhang, M., Habgood, M., Frugier, T., Brody, K. M., Sashindranath, M., . . . Crack, P. J. (2016). Ablation of type-1 IFN signaling in hematopoietic cells confers protection following traumatic brain injury. eNeuro, 3(1), 89-93.
Scopus33 Europe PMC242016 Lebois, M., Dowling, M., Gangatirkar, P., Hodgkin, P., Kile, B., Alexander, W., & Josefsson, E. (2016). Regulation of platelet lifespan in the presence and absence of thrombopoietin signaling. Journal of Thrombosis and Haemostasis, 14(9), 1882-1887.
Scopus14 WoS12 Europe PMC102016 Rowley, J., Chappaz, S., Corduan, A., Chong, M., Campbell, R., Khoury, A., . . . Weyrich, A. (2016). Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets. Blood, 127(14), 1743-1751.
Scopus64 WoS61 Europe PMC412016 Lee, E., Grabow, S., Chappaz, S., Dewson, G., Hockings, C., Kluck, R., . . . Fairlie, W. (2016). Physiological restraint of Bak by Bcl-x⌊ is essential for cell survival. Genes and Development, 30(10), 1240-1250.
Scopus30 WoS25 Europe PMC212016 Keniry, A., Gearing, L. J., Jansz, N., Liu, J., Holik, A. Z., Hickey, P. F., . . . Blewitt, M. E. (2016). Setdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing. Epigenetics & Chromatin, 9(1), 16=1-16-20.
Scopus40 WoS40 Europe PMC332015 Zhang, J. G., Farley, A., Nicholson, S. E., Willson, T. A., Zugaro, L. M., Simpson, R. J., . . . Baca, M. (2015). Correction: The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation (Proceedings of the National Academy of Sciences of the United States of America (1999) 96, 5 (2071-2076) DOI: 10.1073/pnas.96.5.2071). Proceedings of the National Academy of Sciences of the United States of America, 112(22), E2979.
Scopus8 WoS7 Europe PMC22015 White, M., & Kile, B. (2015). Stressed mitochondria sound the alarm. Immunology and Cell Biology, 93(5), 427-428.
Scopus5 WoS5 Europe PMC32015 Kile, B. (2015). Aging platelets stimulate TPO production. Nature Medicine, 21(1), 11-12.
Scopus3 WoS3 Europe PMC32015 Carpinelli, M. R., Kruse, E. A., Arhatari, B. D., Debrincat, M. A., Ogier, J. M., Bories, J. C., . . . Burt, R. A. (2015). Mice haploinsufficient for Ets1 and Fli1 display middle ear abnormalities and model aspects of Jacobsen syndrome. American Journal of Pathology, 185(7), 1867-1876.
Scopus11 WoS10 Europe PMC92015 Debrincat, M., Pleines, I., Lebois, M., Lane, R., Holmes, M., Corbin, J., . . . Josefsson, E. (2015). BCL-2 is dispensable for thrombopoiesis and platelet survival. Cell Death and Disease, 6(4), e1721-1-e1721-8.
Scopus45 WoS42 Europe PMC302015 Schevzov, G., Kee, A., Wang, B., Sequeira, V., Hook, J., Coombes, J., . . . Gunning, P. (2015). Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments. Molecular Biology of the Cell, 26(13), 2475-2490.
Scopus42 WoS40 Europe PMC322015 Brown, F., Conway, A., Cerruti, L., Collinge, J., McLean, C., Wiley, J., . . . Curtis, D. (2015). Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model. Blood, 126(26), 2863-2870.
Scopus10 WoS12 Europe PMC102015 Chirn, G., Rahman, R., Sytnikova, Y., Matts, J., Zeng, M., Gerlach, D., . . . Lau, N. (2015). Conserved piRNA expression from a distinct set of piRNA cluster loci in eutherian mammals. PLoS Genetics, 11(11), e1005652-1-e1005652-26.
Scopus46 WoS45 Europe PMC402015 Kedzierski, L., Clemens, E., Bird, N., Kile, B., Belz, G., Nicola, N., . . . Nicholson, S. (2015). SOCS4 is dispensable for an efficient recall response to influenza despite being required for primary immunity. Immunology and Cell Biology, 93(10), 909-913.
Scopus8 WoS8 Europe PMC32015 Cottle, D., Ursino, G., Ip, S., Jones, L., Ditommaso, T., Hacking, D., . . . Smyth, I. (2015). Fetal inhibition of inflammation improves disease phenotypes in harlequin ichthyosis. Human Molecular Genetics, 24(2), 436-449.
Scopus16 WoS15 Europe PMC142015 Kim, M., Chae, J., Park, Y., De Nardo, D., Stirzaker, R., Ko, H., . . . Masters, S. (2015). Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β. Journal of Experimental Medicine, 212(6), 927-938.
Scopus86 WoS84 Europe PMC702015 Carmichael, C., Goossens, S., Kile, B., & Haigh, J. J. (2015). A novel role for the EMT regulator, snai1, in hematopoiesis and leukemia. Experimental Hematology, 43(9), S56.
2014 Allam, R., Lawlor, K., Yu, E., Mildenhall, A., Moujalled, D., Lewis, R., . . . Vince, J. (2014). Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming. EMBO Reports, 15(9), 982-990.
Scopus146 WoS139 Europe PMC1072014 Josefsson, E., Burnett, D., Lebois, M., Debrincat, M., White, M., Henley, K., . . . Kile, B. (2014). Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways. Nature Communications, 5(1), 3455-1-3455-14.
Scopus52 WoS47 Europe PMC302014 White, M. J., McArthur, K., Metcalf, D., Lane, R. M., Cambier, J. C., Herold, M. J., . . . Kile, B. T. (2014). Apoptotic caspases suppress mtDNA-induced STING-mediated type i IFN production. Cell, 159(7), 1549-1562.
Scopus453 WoS450 Europe PMC3402014 Kedzierski, L., Linossi, E., Kolesnik, T., Day, E., Bird, N., Kile, B., . . . Nicholson, S. (2014). Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection. PLoS Pathogens, 10(5), e1004134-1-e1004134-13.
Scopus40 WoS37 Europe PMC322014 Vandenberg, C., Josefsson, E., Campbell, K., James, C., Lawlor, K., Kile, B., & Cory, S. (2014). Loss of Bak enhances lymphocytosis but does not ameliorate thrombocytopaenia in BCL-2 transgenic mice. Cell Death and Differentiation, 21(5), 676-684.
Scopus13 WoS11 Europe PMC92014 Mitchell, W., Pinheiro, M., Boulad, N., Kaplan, D., Edison, M., Psaila, B., . . . Bussel, J. (2014). Effect of thrombopoietin receptor agonists on the apoptotic profile of platelets in patients with chronic immune thrombocytopenia. American Journal of Hematology, 89(12), E228-E234.
Scopus25 WoS26 Europe PMC182014 Potts, K. S., Sargeant, T. J., Markham, J. F., Shi, W., Biben, C., Josefsson, E. C., . . . Taoudi, S. (2014). A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo. Blood, 124(17), 2725-2729.
Scopus36 WoS31 Europe PMC202014 Ogier, J., Carpinelli, M., Arhatari, B., Symons, R., Kile, B., & Burt, R. (2014). CHD7 deficiency in " Looper", a new mouse model of CHARGE syndrome, results in ossicle malformation, otosclerosis and hearing impairment. PLoS ONE, 9(5), e97559-1-e97559-11.
Scopus14 WoS14 Europe PMC102014 Gerlic, M., Croker, B., Cengia, L., Moayeri, M., Kile, B., & Masters, S. (2014). NLRP1a expression in srebp-1a-deficient mice. Cell Metabolism, 19(3), 345-346.
Scopus5 WoS5 Europe PMC22014 Carpinelli, M. R., Voss, A. K., Manning, M. G., Perera, A. A., Cooray, A. A., Kile, B. T., & Burt, R. A. (2014). A new mouse model of Canavan leukodystrophy displays hearing impairment due to central nervous system dysmyelination. Disease Models and Mechanisms, 7(6), 649-657.
Scopus10 WoS10 Europe PMC62014 Liu, Z., Hoffmeister, K., Hu, Z., Mager, D., Ait-Oudhia, S., Debrincat, M., . . . Sola-Visner, M. (2014). Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan. Blood, 123(22), 3381-3389.
Scopus47 WoS43 Europe PMC332014 Kile, B. (2014). The role of apoptosis in megakaryocytes and platelets. British Journal of Haematology, 165(2), 217-226.
Scopus87 WoS75 Europe PMC542013 Dowling, M., Josefsson, E., Henley, K., Kile, B., & Hodgkin, P. (2013). A model for studying the hemostatic consumption or destruction of platelets. PLoS ONE, 8(3), e57783-1-e57783-14.
Scopus6 WoS4 Europe PMC52013 Tang, J., Carmichael, C., Shi, W., Metcalf, D., Ng, A., Hyland, C., . . . Alexander, W. (2013). Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia. Proceedings of the National Academy of Sciences, 110(15), 6091-6096.
Scopus16 WoS16 Europe PMC142013 Carpinelli, M., Manning, M., Kile, B., & Rachel, A. (2013). Two ENU-induced alleles of Atp2b2 cause deafness in mice. PLoS ONE, 8(6), e67479-1-e67479-8.
Scopus9 WoS10 Europe PMC92013 Downes, C., Wong, C., Henley, K., Guio-Aguilar, P., Zhang, M., Ates, R., . . . Crack, P. (2013). MyD88 is a critical regulator of hematopoietic cell-mediated neuroprotection seen after stroke. PLoS ONE, 8(3), e57948.
Scopus19 WoS19 Europe PMC142013 Fu, Y., Mukhamedova, N., Ip, S., D'Souza, W., Henley, K., Ditommaso, T., . . . Sviridov, D. (2013). ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis. Cell Metabolism, 18(2), 225-238.
Scopus41 WoS41 Europe PMC262013 Takiguchi, M., Dow, L., Prier, J., Carmichael, C., Kile, B., Turner, S., . . . Dickins, R. (2013). Variability of inducible expression across the hematopoietic system of tetracycline transactivator transgenic mice. PLoS ONE, 8(1), e54009-1-e54009-10.
Scopus18 WoS18 Europe PMC182013 Brown, F. C., Scott, N., Rank, G., Collinge, J. E., Vadolas, J., Vickaryous, N., . . . Curtis, D. J. (2013). ENU mutagenesis identifies the first mouse mutants reproducing human β-thalassemia at the genomic level. Blood Cells, Molecules, and Diseases, 50(2), 86-92.
Scopus14 WoS13 Europe PMC122013 Fleming, P., Kvansakul, M., Voigt, V., Kile, B., Kluck, R., Huang, D., . . . Andoniou, C. (2013). MCMV-mediated inhibition of the pro-apoptotic bak protein is required for optimal in vivo replication. PLoS Pathogens, 9(2), e1003192-1-e1003192-12.
Scopus19 WoS18 Europe PMC142013 Mason, K., Lin, A., Robb, L., Josefsson, E., Henley, K., Gray, D., . . . O'Reilly, L. (2013). Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease. Proceedings of the National Academy of Sciences of the United States of America, 110(7), 2599-2604.
Scopus38 WoS35 Europe PMC292013 Qiao, J., Schoenwaelder, S. M., Mason, K. D., Tran, H., Davis, A. K., Kaplan, Z. S., . . . Gardiner, E. E. (2013). Low adhesion receptor levels on circulating platelets in patients with lymphoproliferative diseases before receiving Navitoclax (ABT-263). Blood, 121(8), 1479-1481.
Scopus19 WoS19 Europe PMC102013 Putoczki, T. L., Thiem, S., Loving, A., Busuttil, R. A., Wilson, N. J., Ziegler, P. K., . . . Ernst, M. (2013). Interleukin-11 is the dominant Il-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically. Cancer Cell, 24(2), 257-271.
Scopus273 WoS264 Europe PMC1892013 Carpinelli, M. R., Manning, M. G., Kile, B. T., & Burt, R. A. (2013). Erratum: Two ENU-induced alleles of atp2b2 cause deafness in mice. PLoS ONE, 8(7).
Scopus22012 Masters, S., Gerlic, M., Metcalf, D., Preston, S., Pellegrini, M., O'Donnell, J., . . . Croker, B. (2012). NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells. Immunity, 37(6), 1009-1023.
Scopus200 WoS195 Europe PMC1562012 Lindqvist, L., Vikström, I., Chambers, J., McArthur, K., Ann Anderson, M., Henley, K., . . . Huang, D. (2012). Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor. Cell Death and Disease, 3(10), e409-1-e409-9.
Scopus35 WoS34 Europe PMC252012 Zhang, J., Czabotar, P., Policheni, A., Caminschi, I., San Wan, S., Kitsoulis, S., . . . Lahoud, M. (2012). The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments. Immunity, 36(4), 646-657.
Scopus216 WoS205 Europe PMC1702012 White, M. J., Schoenwaelder, S. M., Josefsson, E. C., Jarman, K. E., Henley, K. J., James, C., . . . Kile, B. T. (2012). Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function. Blood, 119(18), 4283-4290.
Scopus56 WoS50 Europe PMC432012 Debrincat, M., Josefsson, E., James, C., Henley, K., Ellis, S., Lebois, M., . . . Kile, B. (2012). Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival. Blood, 119(24), 5850-5858.
Scopus60 WoS56 Europe PMC442012 Josefsson, E. C., White, M. J., Dowling, M. R., & Kile, B. T. (2012). Platelet life span and apoptosis. Methods in Molecular Biology, 788, 59-71.
Scopus23 Europe PMC192012 Carpinelli, M. R., Burt, R. A., & Kile, B. T. (2012). Genetic Modifier Screens in Mice.. Current protocols in mouse biology, 2(1), 75-87.
Europe PMC12012 Kauppi, M., Hilton, A., Metcalf, D., Ng, A., Hyland, C., Collinge, J., . . . Alexander, W. (2012). Thrombocytopenia and erythrocytosis in mice with a mutation in the gene encoding the hemoglobin β minor chain. Proceedings of the National Academy of Sciences of the United States of America, 109(2), 576-581.
Scopus3 WoS3 Europe PMC22012 Kile, B. T. (2012). The spreading influence of platelet HDACs. Blood, 120(20), 4118-4119.
Scopus1 WoS12012 Carmichael, C., Metcalf, D., Henley, K., Kruse, E., Di Rago, L., Mifsud, S., . . . Kile, B. (2012). Hematopoietic overexpression of the transcription factor Erg induces lymphoid and erythro-megakaryocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America, 109(38), 15437-15442.
Scopus35 WoS34 Europe PMC272012 Verhagen, A., De Graaf, C., Baldwin, T., Goradia, A., Collinge, J., Kile, B., . . . Hilton, D. (2012). Reduced lymphocyte longevity and homeostatic proliferation in lamin B receptor-deficient mice results in profound and progressive lymphopenia. Journal of Immunology, 188(1), 122-134.
Scopus7 WoS8 Europe PMC72012 Kraemer, B., Campbell, R., Schwertz, H., Franks, Z., De Abreu, A., Grundler, K., . . . Weyrich, A. (2012). Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets. Blood, 120(25), 5014-5020.
Scopus46 WoS44 Europe PMC352011 Fairfield, H., Gilbert, G. J., Barter, M., Corrigan, R. R., Curtain, M., Ding, Y., . . . Reinholdt, L. G. (2011). Mutation discovery in mice by whole exome sequencing. Genome Biology, 12(9), 12 pages.
Scopus89 WoS84 Europe PMC742011 Josefsson, E. C., James, C., Henley, K. J., Debrincat, M. A., Rogers, K. L., Dowling, M. R., . . . Kile, B. T. (2011). Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets. Journal of Experimental Medicine, 208(10), 2017-2031.
Scopus130 WoS118 Europe PMC1022011 Nguyen, N. Y. N., Maxwell, M. J., Ooms, L. M., Davies, E. M., Hilton, A. A., Collinge, J. E., . . . Curtis, D. J. (2011). An ENU-induced mouse mutant of SHIP1 reveals a critical role of the stem cell isoform for suppression of macrophage activation. Blood, 117(20), 5362-5371.
Scopus14 WoS13 Europe PMC102011 Ng, A. P., Loughran, S. J., Metcalf, D., Hyland, C. D., De Graaf, C. A., Hu, Y., . . . Alexander, W. S. (2011). Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice. Blood, 118(9), 2454-2461.
Scopus37 WoS34 Europe PMC292011 Bishton, M. J., Harrison, S. J., Martin, B. P., McLaughlin, N., James, C., Josefsson, E. C., . . . Johnstone, R. W. (2011). Deciphering the molecular and biologic processes that mediate histone deacetylase inhibitor - Induced thrombocytopenia. Blood, 117(13), 3658-3668.
Scopus116 WoS106 Europe PMC822011 Taoudi, S., Bee, T., Hilton, A., Knezevic, K., Scott, J., Willson, T. A., . . . Hilton, D. J. (2011). ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification. Genes and Development, 25(3), 251-262.
Scopus73 WoS63 Europe PMC552011 Schoenwaelder, S. M., Jarman, K. E., Gardiner, E. E., Hua, M., Qiao, J., White, M. J., . . . Jackson, S. P. (2011). Bcl-x<inf>L</inf>-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets. Blood, 118(6), 1663-1674.
Scopus194 WoS183 Europe PMC1512010 Kelly, P. N., White, M. J., Goschnick, M. W., Fairfax, K. A., Tarlinton, D. M., Kinkel, S. A., . . . Strasser, A. (2010). Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development. Cell Death and Differentiation, 17(10), 1655-1664.
Scopus48 WoS42 Europe PMC372010 Greig, K. T., De Graaf, C. A., Murphy, J. M., Carpinelli, M. R., Pang, S. H. M., Frampton, J., . . . Nutt, S. L. (2010). Critical roles for c-Myb in lymphoid priming and early B-cell development. Blood, 115(14), 2796-2805.
Scopus49 WoS49 Europe PMC432010 Takiguchi, M., James, C., Josefsson, E. C., Carmichael, C. L., Premsrirut, P. K., Lowe, S. W., . . . Dickins, R. A. (2010). Transgenic, inducible RNAi in megakaryocytes and platelets in mice. Journal of Thrombosis and Haemostasis, 8(12), 2751-2756.
Scopus8 WoS8 Europe PMC72010 Ng, A. P., Hyland, C. D., Metcalf, D., Carmichael, C. L., Loughran, S. J., Di Rago, L., . . . Alexander, W. S. (2010). Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome. Blood, 115(19), 3966-3969.
Scopus53 WoS45 Europe PMC432010 Dowling, M. R., Josefsson, E. C., Henley, K. J., Hodgkin, P. D., & Kile, B. T. (2010). Platelet senescence is regulated by an internal timer, not damage inflicted by hits. Blood, 116(10), 1776-1778.
Scopus44 WoS39 Europe PMC322010 White, M. J., & Kile, B. T. (2010). Apoptotic Processes in Megakaryocytes and Platelets. Seminars in Hematology, 47(3), 227-234.
Scopus35 WoS30 Europe PMC262010 Cordell, P. A., Kile, B. T., Standeven, K. F., Josefsson, E. C., Pease, R. J., & Grant, P. J. (2010). Association of coagulation factor XIII-A with Golgi proteins within monocyte-macrophages: Implications for subcellular trafficking and secretion. Blood, 115(13), 2674-2681.
Scopus46 WoS44 Europe PMC382009 Hilton, D. J., Kile, B. T., & Alexander, W. S. (2009). Mutational inhibition of c-Myb or p300 ameliorates treatment-induced thrombocytopenia. Blood, 113(22), 5599-5604.
Scopus7 WoS6 Europe PMC62009 Kruse, E. A., Loughran, S. J., Baldwin, T. M., Josefsson, E. C., Ellis, S., Watson, D. K., . . . Kile, B. T. (2009). Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage. Proceedings of the National Academy of Sciences of the United States of America, 106(33), 13814-13819.
Scopus70 WoS68 Europe PMC452009 Ellett, F., Kile, B. T., & Lieschke, G. J. (2009). The role of the ETS factor erg in zebrafish vasculogenesis. Mechanisms of Development, 126(3-4), 220-229.
Scopus26 WoS24 Europe PMC182009 Rank, G., Sutton, R., Marshall, V., Lundie, R. J., Caddy, J., Romeo, T., . . . Jane, S. M. (2009). Novel roles for erythroid Ankyrin-1 revealed through an ENU-induced null mouse mutant. Blood, 113(14), 3352-3362.
Scopus37 WoS36 Europe PMC332009 Verhagen, A. M., Wallace, M. E., Goradia, A., Jones, S. A., Croom, H. A., Metcalf, D., . . . Starr, R. (2009). A kinase-dead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency. Journal of Immunology, 182(4), 2020-2029.
Scopus14 WoS13 Europe PMC112009 Schoenwaelder, S. M., Yuan, Y., Josefsson, E. C., White, M. J., Yao, Y., Mason, K. D., . . . Jackson, S. P. (2009). Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function. Blood, 114(3), 663-666.
Scopus228 WoS222 Europe PMC1822008 Smyth, I., Hacking, D. F., Hilton, A. A., Mukhamedova, N., Meikle, P. J., Ellis, S., . . . Hilton, D. J. (2008). A mouse model of harlequin ichthyosis delineates a key role for Abca12 in lipid homeostasis. PLoS Genetics, 4(9), 11 pages.
Scopus64 WoS59 Europe PMC482008 Kauppi, M., Murphy, J. M., De Graaf, C. A., Hyland, C. D., Greig, K. T., Metcalf, D., . . . Alexander, W. S. (2008). Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl/mice. Blood, 112(8), 3148-3153.
Scopus26 WoS27 Europe PMC232008 Loughran, S. J., Kruse, E. A., Hacking, D. F., de Graaf, C. A., Hyland, C. D., Willson, T. A., . . . Kile, B. T. (2008). The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells. Nature Immunology, 9(7), 810-819.
Scopus194 WoS179 Europe PMC1572008 Burt, R. A., Joseph, J. E., Milliken, S., Collinge, J. E., & Kile, B. T. (2008). Description of a novel mutation leading to MYH9-related disease. Thrombosis Research, 122(6), 861-863.
Scopus14 WoS14 Europe PMC132007 Kile, B. T., Panopoulos, A. D., Stirzaker, R. A., Hacking, D. F., Tahtamouni, L. H., Willson, T. A., . . . Justice, M. J. (2007). Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia. Blood, 110(7), 2371-2380.
Scopus83 WoS82 Europe PMC642007 Greig, K. T., Antonchuk, J., Metcalf, D., Morgan, P. O., Krebs, D. L., Zhang, J. G., . . . Kile, B. T. (2007). Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development. Molecular and Cellular Biology, 27(16), 5849-5859.
Scopus44 WoS42 Europe PMC352007 Silver, J. D., Hilton, D. J., Bahlo, M., & Kile, B. T. (2007). Probabilistic analysis of recessive mutagenesis screen strategies. Mammalian Genome, 18(1), 5-22.
Scopus4 WoS2 Europe PMC22007 Tucker, E., O'Donnell, K., Fuchsberger, M., Hilton, A. A., Metcalf, D., Greig, K., . . . Starr, R. (2007). A novel mutation in the Nfkb2 gene generates an NF-κB2 "super repressor". Journal of Immunology, 179(11), 7514-7522.
Scopus63 WoS64 Europe PMC552007 Mason, K. D., Carpinelli, M. R., Fletcher, J. I., Collinge, J. E., Hilton, A. A., Ellis, S., . . . Kile, B. T. (2007). Programmed Anuclear Cell Death Delimits Platelet Life Span. Cell, 128(6), 1173-1186.
Scopus747 WoS703 Europe PMC5722007 Debrincat, M. A., Zhang, J. G., Willson, T. A., Silke, J., Connolly, L. M., Simpson, R. J., . . . Hilton, D. J. (2007). Ankyrin repeat and suppressors of cytokine signaling box protein Asb-9 targets creatine kinase B for degradation. Journal of Biological Chemistry, 282(7), 4728-4737.
Scopus42 WoS41 Europe PMC312006 Alexander, W. S., Viney, E. M., Zhang, J. G., Metcalf, D., Kauppi, M., Hyland, C. D., . . . Hilton, D. J. (2006). Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene. Proceedings of the National Academy of Sciences of the United States of America, 103(44), 16442-16447.
Scopus64 WoS59 Europe PMC462005 Kile, B. T., & Hilton, D. J. (2005). The art and design of genetic screens: Mouse. Nature Reviews Genetics, 6(7), 557-567.
Scopus73 WoS65 Europe PMC472003 Kile, B. T., Hentges, K. E., Clark, A. T., Nakamura, H., Salinger, A. P., Liu, B., . . . Justice, M. J. (2003). Functional genetic analysis of mouse chromosome 11. Nature, 425(6953), 81-86.
Scopus175 WoS159 Europe PMC1392003 Kile, B. T., Mason-Garrison, C. L., & Justice, M. J. (2003). Sex and strain-related differences in the peripheral blood cell values of inbred mouse strains. Mammalian Genome, 14(1), 81-85.
Scopus34 WoS36 Europe PMC312002 Kile, B. T., Schulman, B. A., Alexander, W. S., Nicola, N. A., Martin, H. M. E., & Hilton, D. J. (2002). The SOCS box: A tale of destruction and degradation. Trends in Biochemical Sciences, 27(5), 235-241.
Scopus349 WoS328 Europe PMC2402001 Kile, B. T., Metcalf, D., Mifsud, S., DiRago, L., Nicola, N. A., Hilton, D. J., & Alexander, W. S. (2001). Functional analysis of Asb-1 using genetic modification in mice. Molecular and Cellular Biology, 21(18), 6189-6197.
Scopus48 WoS46 Europe PMC342001 Kile, B. T., & Alexander, W. S. (2001). The suppressors of cytokine signalling (SOCS). Cellular and Molecular Life Sciences, 58(11), 1627-1635.
Scopus136 WoS133 Europe PMC962001 Kile, B. T., Nicola, N. A., & Alexander, W. S. (2001). Negative regulators of cytokine signaling. International Journal of Hematology, 73(3), 292-298.
Scopus61 WoS57 Europe PMC432000 Kile, B. T., Viney, E. M., Willson, T. A., Brodnicki, T. C., Cancilla, M. R., Herlihy, A. S., . . . Alexander, W. S. (2000). Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4. Gene, 258(1-2), 31-41.
Scopus39 WoS41 Europe PMC291999 Cutts, S. M., Fowler, K. J., Kile, B. T., Hii, L. L. P., O'Dowd, R. A., Hudson, D. F., . . . Choo, K. H. A. (1999). Defective chromosome segregation, microtubule bundling and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice. Human Molecular Genetics, 8(7), 1145-1155.
Scopus86 WoS85 Europe PMC651999 Zhang, J. G., Farley, A., Nicholson, S. E., Willson, T. A., Zugaro, L. M., Simpson, R. J., . . . Baca, M. (1999). The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proceedings of the National Academy of Sciences of the United States of America, 96(5), 2071-2076.
Scopus516 WoS502 Europe PMC3461999 Alexander, W. S., Starr, R., Metcalf, D., Nicholson, S. E., Farley, A., Elefanty, A. G., . . . Hilton, D. J. (1999). Suppressors of cytokine signaling (SOCS): Negative regulators of signal transduction. Journal of Leukocyte Biology, 66(4), 588-592.
Scopus97 WoS92 Europe PMC551999 Saffery, R., Irvine, D. V., Kile, B. T., Hudson, D. F., Cutts, S. M., & Choo, K. H. A. (1999). Cloning, expression, and promoter structure of a mammalian inner centromere protein (INCENP). Mammalian Genome, 10(4), 415-418.
Scopus8 WoS8 Europe PMC61998 Fowler, K., Saffery, R., Kile, B., Irvine, D., Hudson, D., Trowell, H., & Choo, K. (1998). Genetic mapping of mouse centromere protein (Incenp and Cenpe) genes. Cytogenetics and Cell Genetics, 82(1-2), 67-70.
Scopus4 WoS4 Europe PMC2Salmon, J. M., Todorovski, I., Vervoort, S. J., Stanley, K. L., Kearney, C. J., Martelotto, L., . . . Johnstone, R. W. (n.d.). Epigenetic reprogramming of plasmacytoid dendritic cells drives type I interferon-dependent differentiation of acute myeloid leukemias for therapeutic benefit.
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Book Chapters
Year Citation 2013 Josefsson, E. C., Dowling, M. R., Lebois, M., & Kile, B. T. (2013). The Regulation of Platelet Life Span. In Platelets (pp. 51-65). Elsevier.
Scopus182009 Josefsson, E. C., & Kile, B. T. (2009). Cell death in the hematopoietic system. In Essentials of Apoptosis: A Guide for Basic and Clinical Research (pp. 443-459). Humana Press.
Scopus3 -
Conference Papers
Year Citation 2009 Kile, B. T. (2009). The role of the intrinsic apoptosis pathway in platelet life and death. In Journal of Thrombosis and Haemostasis Vol. 7 (pp. 214-217). Boston, MA: WILEY.
Scopus57 WoS55 Europe PMC37
2018-2021 DHB Foundation managed by ANZ Trustees. The development of small molecule inhibitors of cell death. $800,000. CIA: BT Kile, CIB: G Lessene.
2017-2021 NHMRC Program Grant No. 1113577: Regulation of Haemopoietic and Immune Cells in Health and Disease. $19,924,985. CIA: WS Alexander, CIB: JJ Babon, CIC: MC Cook, CID: DJ Hilton, CIE: BT Kile, CIF: NA Nicola, CIG: AW Roberts, CIH: CG Vinuesa, CII: IP Wicks.
2015-2018 NHMRC Project Grant No. 1077750: The role of apoptotic caspases in regulating type I interferon production. $761,513. CIA: BT Kile, CIB: M Pellegrini.
2014-2018 NHMRC Principal Research Fellowship No. 1063008. $727,610. CI: BT Kile.
2014-2017 DHB Foundation managed by ANZ Trustees. The development of small molecule inhibitors of cell death. $650,000. CIA: BT Kile, CIB: G Lessene.
2013 Leukaemia Foundation of Australia Research Grant-in-aid. Elucidation of the mechanisms involved in the development of erythromegakaryocytic leukaemia driven by the proto-oncogene ETS-related gene ERG. $100,000. CIA: CL Carmichael, CIB: BT Kile.
2012-2016 NHMRC Program Grant No. 1016647: Molecular regulation of blood cell production and function. $17,100,000. CIA: NA Nicola, CIB: WS Alexander, CIC: DJ Hilton, CID: D Metcalf, CIE: AW Roberts, CIF: JG Zhang, CIG: SE Nicholson, CIH: BT Kile, CII: IP Wicks.
2011-2013 NHMRC Project Grant No. 1002426: Defining the role of Nlrp1 and the inflammasome in host defence and inflammatory disease. $612,561. CIA: BT Kile, CIB: B Croker, CIC: SL Masters.
2009-2011 NHMRC Project Grant No. 545906: The role of the ABCA12 transporter in epidermal lipid homeostasis and atherosclerosis. $496,250. CIA: I Smyth, CIB: D Sviridov, CIC: BT Kile.
2009-2011 NHMRC Project Grant No. 575535: Bcl-2 proteins and the regulation of the megakaryocyte lineage. $399,900. CIA: BT Kile, CIB: C James.
2009-2013 Sylvia & Charles Viertel Foundation Senior Medical Research Fellowship. $975,000. CI: BT Kile.
2008-2010 NHMRC Project Grant No. 516726: Role of the Ets family transcription factor Erg in stem cell function and leukemia development. $397,125 CIA: BT Kile.
2008-2010 NHMRC Project Grant No. 516725: The molecular regulation of platelet life span. $521,000. CIA: BT Kile, CIB: SP Jackson, CIC: AW Roberts.
2007-2011 Cancer Council of Victoria Venture Grant No. Scanning the genome for new drug targets in cancer CIA: WS Alexander, CIB: BT Kile, CIC: A Strasser. 2007-2011. $244,500.
2007-2009 NHMRC Project Grant No. 461247: The genetic control of platelet production and function. $537,000 CIA: BT Kile, CIB: WS Alexander, CIC: HH Nandurkar.
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