Benjamin Kile
School of Biomedicine
Faculty of Health and Medical Sciences
Ben is Executive Dean of the Faculty of Health and Medical Sciences at the University of Adelaide. His PhD was conducted at the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia, under the supervision of Professors Warren Alexander and Douglas Hilton. Graduating in 2001, Ben pursued postdoctoral studies with Professor Monica Justice at Baylor College of Medicine, Houston, USA. In 2004 he returned to the Walter and Eliza Hall Institute, joining the faculty in 2005, and being appointed an independent laboratory head in 2008. After jointly leading the institute's ACRF Chemical Biology Division from 2014-2017, Ben took up the position of Head, Department of Anatomy and Developmental Biology, within the Biomedicine Discovery Institute at Monash University. In October 2019 he moved to the University of Adelaide.
The Kile lab's research has focused primarily on the molecular regulation of blood cell formation and function, at steady state, and in disease settings such as inflammation and leukemia. We have a deep interest in the role programmed cell death pathways play in these processes, and how the cell death machinery mediates the response to pathophysiological insults such as cancer chemotherapy. Our work has contributed to understanding the survival of platelets – the tiny cells that mediate blood clotting – and informed the clinical development of a new class of cancer drugs called the BH3 mimetics. We have identified critical roles for the cell death machinery in suppressing innate immune signalling, suggesting new therapeutic approaches to the treatment of viral infections and cancer.
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Appointments
Date Position Institution name 2019 - ongoing Executive Dean Faculty of Health and Medical Sciences 2017 - 2019 Head, Department of Anatomy and Developmental Biology Monash University 2014 - 2017 Head, ACRF Chemical Biology Division Walter and Eliza Hall Institute of Medical Research 2012 - ongoing Board Member Australian Genomics Research Facility 2008 - 2013 Laboratory Head Walter and Eliza Hall Institute of Medical Research -
Education
Date Institution name Country Title 2001 University of Melbourne Australia PhD 1997 University of Melbourne Australia BSc(Hons) 1995 Monash University Australia LLB 1993 Monash University Australia BSc -
Research Interests
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Journals
Year Citation 2024 Thilakasiri, P., O'Keefe, R. N., To, S. Q., Chisanga, D., Eissmann, M. F., Carli, A. L., . . . Chand, A. L. (2024). Mechanisms of cellular crosstalk in the gastric tumor microenvironment are mediated by YAP1 and STAT3. Life Science Alliance, 7(2), e202302411-1-e202302411-17.
Scopus1 Europe PMC12024 El-Mortada, F., Landelouci, K., Bertrand-Perron, S., Aubé, F. A., Poirier, A., Bidias, A., . . . Pépin, G. (2024). Megakaryocytes possess a STING pathway that is transferred to platelets to potentiate activation. Life Science Alliance, 7(2), 11 pages.
Scopus1 Europe PMC22024 Saunders, T. L., Windley, S. P., Gervinskas, G., Balka, K. R., Rowe, C., Lane, R., . . . McArthur, K. (2024). Exposure of the inner mitochondrial membrane triggers apoptotic mitophagy. Cell Death and Differentiation, 31(3), 335-347.
Scopus5 Europe PMC32024 McArthur, K., & Kile, B. T. (2024). mtDNA caught in the act again. Nature Cell Biology, 26(2), 177-178.
Scopus12024 Tran, S., Juliani, J., Harris, T. J., Evangelista, M., Ratcliffe, J., Ellis, S. L., . . . Lee, E. F. (2024). BECLIN1 is essential for intestinal homeostasis involving autophagy-independent mechanisms through its function in endocytic trafficking. Communications Biology, 7(1), 13 pages.
Scopus1 Europe PMC12024 Murray, J. E., Valli, E., Milazzo, G., Mayoh, C., Gifford, A. J., Fletcher, J. I., . . . Norris, M. D. (2024). The transcriptional co-repressor Runx1t1 is essential for MYCN-driven neuroblastoma tumorigenesis. Nature Communications, 15(1), 5585.
2024 Cheung, B. B., Mittra, R., Murray, J., Wang, Q., Seneviratne, J. A., Raipuria, M., . . . Marshall, G. M. (2024). Golgi-localized Ring Finger Protein 121 is necessary for MYCN-driven neuroblastoma tumorigenesis. Communications Biology, 7(1), 1322.
2023 Heazlewood, S. Y., Ahmad, T., Cao, B., Cao, H., Domingues, M., Sun, X., . . . Nilsson, S. K. (2023). High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production. Nature communications, 14(1), 18 pages.
Scopus11 Europe PMC62023 Balka, K. R., Venkatraman, R., Saunders, T. L., Shoppee, A., Pang, E. S., Magill, Z., . . . De Nardo, D. (2023). Termination of STING responses is mediated via ESCRT-dependent degradation. EMBO Journal, 42(12), e112712-1-e112712-21.
Scopus16 WoS7 Europe PMC122023 Ullah, T. R., Johansen, M. D., Balka, K. R., Ambrose, R. L., Gearing, L. J., Roest, J., . . . Gantier, M. P. (2023). Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection. Nature Communications, 14(1), 1-13.
Scopus6 Europe PMC52023 Richman, T. R., Ermer, J. A., Baker, J., Siira, S. J., Kile, B. T., Linden, M. D., . . . Filipovska, A. (2023). Mitochondrial gene expression is required for platelet function and blood clotting. Cell Reports, 42(11), 113312-1-113312-19.
Scopus5 Europe PMC22022 Davidson, S., Yu, C. -H., Steiner, A., Ebstein, F., Baker, P. J., Jarur-Chamy, V., . . . Masters, S. L. (2022). Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24. Science Immunology, 7(68), eabi6763-1-eabi6763-?.
Scopus32 WoS11 Europe PMC222022 Pang, E. S., Daraj, G., Balka, K. R., De Nardo, D., Macri, C., Hochrein, H., . . . O'Keeffe, M. (2022). Discordance in STING-Induced Activation and Cell Death Between Mouse and Human Dendritic Cell Populations. Frontiers in immunology, 13, 794776-1-794776-19.
Scopus11 WoS3 Europe PMC102022 Salmon, J. M., Todorovski, I., Stanley, K. L., Bruedigam, C., Kearney, C. J., Martelotto, L. G., . . . Johnstone, R. W. (2022). Epigenetic activation of plasmacytoid DC drives IFNAR-dependent therapeutic differentiation of AML. Cancer Discovery, 12(6), 1560-1579.
Scopus14 WoS5 Europe PMC82021 Lee, M. K. S., Kraakman, M. J., Dragoljevic, D., Hanssen, N. M. J., Flynn, M. C., Al-Sharea, A., . . . Murphy, A. J. (2021). Apoptotic ablation of platelets reduces atherosclerosis in mice with diabetes. Arteriosclerosis, Thrombosis and Vascular Biology, 41(3), 1167-1178.
Scopus12 WoS8 Europe PMC102021 Chappaz, S., Saunders, T. L., & Kile, B. T. (2021). Generation of murine bone marrow and fetal liver chimeras. Current Protocols, 1(4), e79-1-e79-20.
Scopus1 Europe PMC12021 Strassel, C., Magiera, M. M., Dupuis, A., Batzenschlager, M., Hovasse, A., Pleines, I., . . . Lanza, F. (2021). Correction: An essential role for α4A-tubulin in platelet biogenesis.. Life science alliance, 4(8), e202101132.
2021 Chappaz, S., McArthur, K., Kealy, L., Law, C. W., Tailler, M., Lane, R. M., . . . Kile, B. T. (2021). Homeostatic apoptosis prevents competition-induced atrophy in follicular B cells. Cell Reports, 36(3), 1-7.
Scopus3 WoS1 Europe PMC32021 Ngo, S., Oxley, E. P., Ghisi, M., Garwood, M. M., McKenzie, M. D., Mitchell, H. L., . . . Dickins, R. A. (2021). Acute myeloid leukemia maturation lineage influences residual disease and relapse following differentiation therapy. Nature Communications, 12(1), 6546-1-6546-14.
Scopus8 WoS5 Europe PMC32020 Pépin, G., De Nardo, D., Rootes, C. L., Ullah, T. R., Al-Asmari, S. S., Balka, K. R., . . . Gantier, M. P. (2020). Connexin-dependent transfer of cgamp to phagocytes modulates antiviral responses. mBio, 11(1), 1-6.
Scopus47 WoS25 Europe PMC322020 Denorme, F., Manne, B. K., Portier, I., Eustes, A. S., Kosaka, Y., Kile, B. T., . . . Campbell, R. A. (2020). Platelet necrosis mediates ischemic stroke outcome in mice. Blood, 135(6), 429-440.
Scopus63 WoS40 Europe PMC462020 Balka, K. R., Louis, C., Saunders, T. L., Smith, A. M., Calleja, D. J., D'Silva, D. B., . . . De Nardo, D. (2020). TBK1 and IKKε act redundantly to mediate STING-induced NF-κB responses in myeloid cells. Cell Reports, 31(1), 107492-1-107492-22.
Scopus237 WoS151 Europe PMC1632020 Chappaz, S., Law, C. W., Dowling, M. R., Carey, K. T., Lane, R. M., Ngo, L. H., . . . Kile, B. T. (2020). Germline heterozygous mutations in Nxf1 perturb RNA metabolism and trigger thrombocytopenia and lymphopenia in mice. Blood Advances, 4(7), 1270-1283.
Scopus5 WoS4 Europe PMC42020 Hildebrand, J. M., Kauppi, M., Majewski, I. J., Liu, Z., Cox, A. J., Miyake, S., . . . Silke, J. (2020). A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction. Nature Communications, 11(1), 3150.
Scopus70 WoS53 Europe PMC572020 Fagnan, A., Bagger, F. O., Piqué-Borràs, M. R., Ignacimouttou, C., Caulier, A., Lopez, C. K., . . . Mercher, T. (2020). Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers. Blood, 136(6), 698-714.
Scopus32 WoS19 Europe PMC262020 Deo, P., Chow, S. H., Han, M. L., Speir, M., Huang, C., Schittenhelm, R. B., . . . Naderer, T. (2020). Mitochondrial dysfunction caused by outer membrane vesicles from Gram-negative bacteria activates intrinsic apoptosis and inflammation. Nature Microbiology, 5(11), 1418-1427.
Scopus128 WoS68 Europe PMC752020 Carmichael, C. L., Wang, J., Nguyen, T., Kolawole, O., Benyoucef, A., De Mazière, C., . . . Haigh, J. J. (2020). The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1. Blood, 136(8), 957-973.
Scopus39 WoS19 Europe PMC282020 Denorme, F., Manne, B. K., Portier, I., Petrey, A. C., Middleton, E., Kile, B. T., . . . Campbell, R. A. (2020). COVID-19 patients exhibit reduced procoagulant platelet responses. Journal of thrombosis and haemostasis : JTH, 18(11), 3067-3073.
Scopus53 WoS49 Europe PMC452020 McArthur, K., & Kile, B. T. (2020). Apoptotic mitochondria prime anti-tumour immunity. Cell Death Discovery, 6(1), 3 pages.
Scopus10 WoS8 Europe PMC82020 Salmon, J., Todorovski, I., Vervoort, S., Stanley, K., Kearney, C., Martelotto, L., . . . Johnstone, R. (2020). Epigenetic reprogramming of plasmacytoid dendritic cells drives type I interferon-dependent differentiation of acute myeloid leukemias for therapeutic benefit.
2019 Strassel, C., Magiera, M. M., Dupuis, A., Batzenschlager, M., Hovasse, A., Pleines, I., . . . Lanza, F. (2019). An essential role for α4A-tubulin in platelet biogenesis. Life Science Alliance, 2(1), e201900309-1-e201900309-13.
Scopus36 WoS29 Europe PMC222019 Hildebrand, J., Kauppi, M., Majewski, I., Liu, Z., Cox, A., Miyake, S., . . . Silke, J. (2019). Missense mutations in the MLKL ‘brace’ region lead to lethal neonatal inflammation in mice and are present in high frequency in humans.
2019 Walkley, C. R., & Kile, B. T. (2019). Cell death following the loss of ADAR1 mediated A-to-I RNA editing is not effected by the intrinsic apoptosis pathway. Cell Death and Disease, 10(12), 913.
Scopus14 WoS9 Europe PMC102019 Iacobucci, I., Wen, J., Meggendorfer, M., Choi, J. K., Shi, L., Pounds, S. B., . . . Mullighan, C. G. (2019). Genomic subtyping and therapeutic targeting of acute erythroleukemia. Nature genetics, 51(4), 694-704.
Scopus104 WoS68 Europe PMC752019 Chiu, S. K., Orive, S. L., Moon, M. J., Saw, J., Ellis, S., Kile, B. T., . . . Curtis, D. J. (2019). Shared roles for Scl and Lyl1 in murine platelet production and function. Blood, 134(10), 826-835.
Scopus13 WoS10 Europe PMC62019 Levin, J., & Kile, B. (2019). Acknowledgements: the Levin/Kile rule. Platelets, 30(2), 280.
2019 Jiao, Y., Davis, J. E., Rautela, J., Carrington, E. M., Ludford-Menting, M. J., Goh, W., . . . Huntington, N. D. (2019). Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes. Cell Death and Differentiation, 26(8), 1516-1530.
Scopus10 WoS9 Europe PMC82019 van Delft, M. F., Chappaz, S., Khakham, Y., Bui, C. T., Debrincat, M. A., Lowes, K. N., . . . Kile, B. T. (2019). A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis. Nature Chemical Biology, 15(11), 1057-1066.
Scopus31 WoS19 Europe PMC222018 McArthur, K., Whitehead, L. W., Heddleston, J. M., Li, L., Padman, B. S., Oorschot, V., . . . Kile, B. T. (2018). BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis. Science, 359(6378), 883-+.
Scopus616 WoS437 Europe PMC4222018 Tye, H., Yu, C. H., Simms, L. A., de Zoete, M. R., Kim, M. L., Zakrzewski, M., . . . Masters, S. L. (2018). NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease. Nature Communications, 9(1), 3728-1-3728-11.
Scopus87 WoS59 Europe PMC512018 Pleines, I., Lebois, M., Gangatirkar, P., Au, A. E., Lane, R. M., Henley, K. J., . . . Josefsson, E. C. (2018). Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion. Blood, 132(2), 197-209.
Scopus19 WoS14 Europe PMC112018 McArthur, K., Chappaz, S., & Kile, B. T. (2018). Apoptosis in megakaryocytes and platelets: the life and death of a lineage. Blood, 131(6), 605-610.
Scopus79 WoS61 Europe PMC512018 Lindqvist, L. M., Frank, D., McArthur, K., Dite, T. A., Lazarou, M., Oakhill, J. S., . . . Vaux, D. L. (2018). Autophagy induced during apoptosis degrades mitochondria and inhibits type i interferon secretion. Cell Death and Differentiation, 25(4), 782-794.
Scopus48 WoS33 Europe PMC332018 Rabbolini, D. J., Chun, Y., Latimer, M., Kunishima, S., Fixter, K., Valecha, B., . . . Morel-Kopp, M. C. (2018). Diagnosis and treatment of MYH9-RD in an Australasian cohort with thrombocytopenia. Platelets, 29(8), 793-800.
Scopus16 WoS17 Europe PMC72018 Vince, J. E., De Nardo, D., Gao, W., Vince, A. J., Hall, C., McArthur, K., . . . Lawlor, K. E. (2018). The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation. Cell Reports, 25(9), 2339-2353.e4.
Scopus171 WoS135 Europe PMC1072018 Conway, A. J., Brown, F. C., Rank, G., Kile, B. T., Morton, C. J., Jane, S. M., & Curtis, D. J. (2018). Characterization of Tfrc-mutant mice with microcytic phenotypes. Blood Advances, 2(15), 1914-1922.
Scopus4 WoS4 Europe PMC32018 McArthur, K., & Kile, B. T. (2018). Apoptotic caspases: Multiple or mistaken identities?. Trends in Cell Biology, 28(6), 475-493.
Scopus121 WoS92 Europe PMC642017 Lorenz, V., Ramsey, H., Liu, Z. J., Italiano, J., Hoffmeister, K., Bihorel, S., . . . Ferrer-Marin, F. (2017). Developmental Stage-Specific Manifestations of Absent TPO/c-MPL Signalling in Newborn Mice. Thrombosis and Haemostasis, 117(12), 2322-2333.
Scopus15 WoS12 Europe PMC102017 Conway, A. J., Brown, F. C., Fullinfaw, R. O., Kile, B. T., Jane, S. M., & Curtis, D. J. (2017). A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen. DMM Disease Models and Mechanisms, 10(8), 1005-1013.
Scopus6 WoS4 Europe PMC72017 Brown, F. C., Collett, M., Tremblay, C. S., Rank, G., De Camilli, P., Booth, C. J., . . . Curtis, D. J. (2017). Loss of Dynamin 2 GTPase function results in microcytic anaemia. British Journal of Haematology, 178(4), 616-628.
Scopus7 WoS7 Europe PMC72017 Yuan, Y., Alwis, I., Wu, M. C. L., Kaplan, Z., Ashworth, K., Bark, D., . . . Jackson, S. P. (2017). Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia. Science Translational Medicine, 9(409), eaam5861-1-eaam5861-14.
Scopus58 WoS51 Europe PMC352017 Au, A. E., Lebois, M., Sim, S. A., Cannon, P., Corbin, J., Gangatirkar, P., . . . Josefsson, E. C. (2017). Altered B-lymphopoiesis in mice with deregulated thrombopoietin signaling. Scientific Reports, 7(1), 14953-1-14953-10.
Scopus4 WoS3 Europe PMC42017 Pleines, I., Woods, J., Chappaz, S., Kew, V., Foad, N., Ballester-Beltrán, J., . . . Kile, B. T. (2017). Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia. Journal of Clinical Investigation, 127(3), 814-829.
Scopus49 WoS42 Europe PMC352017 Thirant, C., Ignacimouttou, C., Lopez, C. K., Diop, M., Le Mouël, L., Thiollier, C., . . . Mercher, T. (2017). ETO2-GLIS2 hijacks transcriptional complexes to drive cellular identity and self-renewal in pediatric acute megakaryoblastic leukemia. Cancer Cell, 31(3), 452-465.
Scopus58 WoS53 Europe PMC462017 Viant, C., Guia, S., Hennessy, R. J., Rautela, J., Pham, K., Bernat, C., . . . Huntington, N. D. (2017). Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival. Journal of Experimental Medicine, 214(2), 491-510.
Scopus55 WoS47 Europe PMC442016 Murphy, A. J., Kraakman, M. J., Kammoun, H. L., Dragoljevic, D., Lee, M. K. S., Lawlor, K. E., . . . Masters, S. L. (2016). IL-18 production from the NLRP1 inflammasome prevents obesity and metabolic syndrome. Cell Metabolism, 23(1), 155-164.
Scopus134 WoS109 Europe PMC992016 Delbridge, A. R. D., Chappaz, S., Ritchie, M. E., Kile, B. T., Strasser, A., & Grabow, S. (2016). Loss of PUMA (BBC3) does not prevent thrombocytopenia caused by the loss of BCL-XL (BCL2L1). British Journal of Haematology, 174(6), 962-969.
Scopus7 WoS5 Europe PMC42016 Karve, I. P., Zhang, M., Habgood, M., Frugier, T., Brody, K. M., Sashindranath, M., . . . Crack, P. J. (2016). Ablation of type-1 IFN signaling in hematopoietic cells confers protection following traumatic brain injury. eNeuro, 3(1), e0128-15.2016-1-e0128-15.2016-18.
Scopus50 WoS45 Europe PMC372016 Lebois, M., Dowling, M. R., Gangatirkar, P., Hodgkin, P. D., Kile, B. T., Alexander, W. S., & Josefsson, E. C. (2016). Regulation of platelet lifespan in the presence and absence of thrombopoietin signaling. Journal of Thrombosis and Haemostasis, 14(9), 1882-1887.
Scopus19 WoS16 Europe PMC132016 Rowley, J. W., Chappaz, S., Corduan, A., Chong, M. M. W., Campbell, R., Khoury, A., . . . Weyrich, A. S. (2016). Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets. Blood, 127(14), 1743-1751.
Scopus77 WoS69 Europe PMC512016 Lee, E. F., Grabow, S., Chappaz, S., Dewson, G., Hockings, C., Kluck, R. M., . . . Fairlie, W. D. (2016). Physiological restraint of Bak by Bcl-x⌊ is essential for cell survival. Genes and Development, 30(10), 1240-1250.
Scopus39 WoS33 Europe PMC272016 Keniry, A., Gearing, L. J., Jansz, N., Liu, J., Holik, A. Z., Hickey, P. F., . . . Blewitt, M. E. (2016). Setdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing. Epigenetics & Chromatin, 9(1), 16=1-16-20.
Scopus52 WoS47 Europe PMC412015 Zhang, J. G., Farley, A., Nicholson, S. E., Willson, T. A., Zugaro, L. M., Simpson, R. J., . . . Baca, M. (2015). Correction: The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation (Proceedings of the National Academy of Sciences of the United States of America (1999) 96, 5 (2071-2076) DOI: 10.1073/pnas.96.5.2071). Proceedings of the National Academy of Sciences of the United States of America, 112(22), E2979.
Scopus8 WoS8 Europe PMC42015 White, M., & Kile, B. (2015). Stressed mitochondria sound the alarm. Immunology and Cell Biology, 93(5), 427-428.
Scopus5 WoS5 Europe PMC32015 Kile, B. (2015). Aging platelets stimulate TPO production. Nature Medicine, 21(1), 11-12.
Scopus7 WoS4 Europe PMC52015 Carpinelli, M. R., Kruse, E. A., Arhatari, B. D., Debrincat, M. A., Ogier, J. M., Bories, J. C., . . . Burt, R. A. (2015). Mice haploinsufficient for Ets1 and Fli1 display middle ear abnormalities and model aspects of Jacobsen syndrome. American Journal of Pathology, 185(7), 1867-1876.
Scopus14 WoS10 Europe PMC102015 Debrincat, M. A., Pleines, I., Lebois, M., Lane, R. M., Holmes, M. L., Corbin, J., . . . Josefsson, E. C. (2015). BCL-2 is dispensable for thrombopoiesis and platelet survival. Cell Death and Disease, 6(4), e1721-1-e1721-8.
Scopus64 WoS47 Europe PMC422015 Schevzov, G., Kee, A. J., Wang, B., Sequeira, V. B., Hook, J., Coombes, J. D., . . . Gunning, P. W. (2015). Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments. Molecular Biology of the Cell, 26(13), 2475-2490.
Scopus51 WoS46 Europe PMC402015 Brown, F. C., Conway, A. J., Cerruti, L., Collinge, J. E., McLean, C., Wiley, J. S., . . . Curtis, D. J. (2015). Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model. Blood, 126(26), 2863-2870.
Scopus16 WoS14 Europe PMC142015 Chirn, G. W., Rahman, R., Sytnikova, Y. A., Matts, J. A., Zeng, M., Gerlach, D., . . . Lau, N. C. (2015). Conserved piRNA expression from a distinct set of piRNA cluster loci in eutherian mammals. PLoS Genetics, 11(11), e1005652-1-e1005652-26.
Scopus61 WoS47 Europe PMC532015 Kedzierski, L., Clemens, E. B., Bird, N. L., Kile, B. T., Belz, G. T., Nicola, N. A., . . . Nicholson, S. E. (2015). SOCS4 is dispensable for an efficient recall response to influenza despite being required for primary immunity. Immunology and Cell Biology, 93(10), 909-913.
Scopus10 WoS8 Europe PMC32015 Cottle, D. L., Ursino, G. M. A., Ip, S. C. I., Jones, L. K., Ditommaso, T., Hacking, D. F., . . . Smyth, I. M. (2015). Fetal inhibition of inflammation improves disease phenotypes in harlequin ichthyosis. Human Molecular Genetics, 24(2), 436-449.
Scopus20 WoS16 Europe PMC182015 Kim, M. L., Chae, J. J., Park, Y. H., De Nardo, D., Stirzaker, R. A., Ko, H. J., . . . Masters, S. L. (2015). Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β. Journal of Experimental Medicine, 212(6), 927-938.
Scopus111 WoS91 Europe PMC852015 Carmichael, C., Goossens, S., Kile, B., & Haigh, J. J. (2015). A NOVEL ROLE FOR THE EMT REGULATOR, SNAIL IN HEMATOPOIESIS AND LEUKEMIA. EXPERIMENTAL HEMATOLOGY, 43(9), S56.
WoS12014 Allam, R., Lawlor, K. E., Yu, E. C. W., Mildenhall, A. L., Moujalled, D. M., Lewis, R. S., . . . Vince, J. E. (2014). Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming. EMBO Reports, 15(9), 982-990.
Scopus188 WoS164 Europe PMC1412014 Josefsson, E. C., Burnett, D. L., Lebois, M., Debrincat, M. A., White, M. J., Henley, K. J., . . . Kile, B. T. (2014). Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways. Nature Communications, 5(1), 3455-1-3455-14.
Scopus68 WoS50 Europe PMC392014 White, M. J., McArthur, K., Metcalf, D., Lane, R. M., Cambier, J. C., Herold, M. J., . . . Kile, B. T. (2014). Apoptotic caspases suppress mtDNA-induced STING-mediated type i IFN production. Cell, 159(7), 1549-1562.
Scopus706 WoS571 Europe PMC5112014 Kedzierski, L., Linossi, E. M., Kolesnik, T. B., Day, E. B., Bird, N. L., Kile, B. T., . . . Nicholson, S. E. (2014). Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection. PLoS Pathogens, 10(5), e1004134-1-e1004134-13.
Scopus55 WoS41 Europe PMC412014 Vandenberg, C. J., Josefsson, E. C., Campbell, K. J., James, C., Lawlor, K. E., Kile, B. T., & Cory, S. (2014). Loss of Bak enhances lymphocytosis but does not ameliorate thrombocytopaenia in BCL-2 transgenic mice. Cell Death and Differentiation, 21(5), 676-684.
Scopus15 WoS12 Europe PMC102014 Mitchell, W. B., Pinheiro, M. P., Boulad, N., Kaplan, D., Edison, M. N., Psaila, B., . . . Bussel, J. B. (2014). Effect of thrombopoietin receptor agonists on the apoptotic profile of platelets in patients with chronic immune thrombocytopenia. American Journal of Hematology, 89(12), E228-E234.
Scopus33 WoS26 Europe PMC222014 Potts, K. S., Sargeant, T. J., Markham, J. F., Shi, W., Biben, C., Josefsson, E. C., . . . Taoudi, S. (2014). A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo. Blood, 124(17), 2725-2729.
Scopus50 WoS34 Europe PMC302014 Ogier, J. M., Carpinelli, M. R., Arhatari, B. D., Symons, R. C. A., Kile, B. T., & Burt, R. A. (2014). CHD7 deficiency in " Looper", a new mouse model of CHARGE syndrome, results in ossicle malformation, otosclerosis and hearing impairment. PLoS ONE, 9(5), e97559-1-e97559-11.
Scopus20 WoS16 Europe PMC172014 Gerlic, M., Croker, B., Cengia, L., Moayeri, M., Kile, B., & Masters, S. (2014). NLRP1a expression in srebp-1a-deficient mice. Cell Metabolism, 19(3), 345-346.
Scopus6 WoS5 Europe PMC42014 Carpinelli, M. R., Voss, A. K., Manning, M. G., Perera, A. A., Cooray, A. A., Kile, B. T., & Burt, R. A. (2014). A new mouse model of Canavan leukodystrophy displays hearing impairment due to central nervous system dysmyelination. Disease Models and Mechanisms, 7(6), 649-657.
Scopus11 WoS11 Europe PMC82014 Liu, Z. J., Hoffmeister, K. M., Hu, Z., Mager, D. E., Ait-Oudhia, S., Debrincat, M. A., . . . Sola-Visner, M. (2014). Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan. Blood, 123(22), 3381-3389.
Scopus56 WoS47 Europe PMC382014 Kile, B. T. (2014). The role of apoptosis in megakaryocytes and platelets. British Journal of Haematology, 165(2), 217-226.
Scopus103 WoS76 Europe PMC642013 Dowling, M. R., Josefsson, E. C., Henley, K. J., Kile, B. T., & Hodgkin, P. D. (2013). A model for studying the hemostatic consumption or destruction of platelets. PLoS ONE, 8(3), e57783-1-e57783-14.
Scopus6 WoS4 Europe PMC52013 Tang, J. Z., Carmichael, C. L., Shi, W., Metcalf, D., Ng, A. P., Hyland, C. D., . . . Alexander, W. S. (2013). Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia. Proceedings of the National Academy of Sciences, 110(15), 6091-6096.
Scopus18 WoS17 Europe PMC162013 Carpinelli, M. R., Manning, M. G., Kile, B. T., & Rachel, A. B. (2013). Two ENU-induced alleles of Atp2b2 cause deafness in mice. PLoS ONE, 8(6), e67479-1-e67479-8.
Scopus9 WoS10 Europe PMC92013 Downes, C. E., Wong, C. H. Y., Henley, K. J., Guio-Aguilar, P. L., Zhang, M., Ates, R., . . . Crack, P. J. (2013). MyD88 is a critical regulator of hematopoietic cell-mediated neuroprotection seen after stroke. PLoS ONE, 8(3), e57948.
Scopus19 WoS19 Europe PMC152013 Fu, Y., Mukhamedova, N., Ip, S., D'Souza, W., Henley, K. J., Ditommaso, T., . . . Sviridov, D. (2013). ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis. Cell Metabolism, 18(2), 225-238.
Scopus45 WoS42 Europe PMC282013 Takiguchi, M., Dow, L. E., Prier, J. E., Carmichael, C. L., Kile, B. T., Turner, S. J., . . . Dickins, R. A. (2013). Variability of inducible expression across the hematopoietic system of tetracycline transactivator transgenic mice. PLoS ONE, 8(1), e54009-1-e54009-10.
Scopus23 WoS19 Europe PMC222013 Brown, F. C., Scott, N., Rank, G., Collinge, J. E., Vadolas, J., Vickaryous, N., . . . Curtis, D. J. (2013). ENU mutagenesis identifies the first mouse mutants reproducing human β-thalassemia at the genomic level. Blood Cells, Molecules, and Diseases, 50(2), 86-92.
Scopus15 WoS13 Europe PMC132013 Fleming, P., Kvansakul, M., Voigt, V., Kile, B. T., Kluck, R. M., Huang, D. C. S., . . . Andoniou, C. E. (2013). MCMV-mediated inhibition of the pro-apoptotic bak protein is required for optimal in vivo replication. PLoS Pathogens, 9(2), e1003192-1-e1003192-12.
Scopus25 WoS19 Europe PMC192013 Mason, K. D., Lin, A., Robb, L., Josefsson, E. C., Henley, K. J., Gray, D. H. D., . . . O'Reilly, L. A. (2013). Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease. Proceedings of the National Academy of Sciences of the United States of America, 110(7), 2599-2604.
Scopus45 WoS35 Europe PMC342013 Qiao, J., Schoenwaelder, S. M., Mason, K. D., Tran, H., Davis, A. K., Kaplan, Z. S., . . . Gardiner, E. E. (2013). Low adhesion receptor levels on circulating platelets in patients with lymphoproliferative diseases before receiving Navitoclax (ABT-263). Blood, 121(8), 1479-1481.
Scopus20 WoS20 Europe PMC112013 Putoczki, T. L., Thiem, S., Loving, A., Busuttil, R. A., Wilson, N. J., Ziegler, P. K., . . . Ernst, M. (2013). Interleukin-11 is the dominant Il-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically. Cancer Cell, 24(2), 257-271.
Scopus338 WoS277 Europe PMC2372013 Carpinelli, M. R., Manning, M. G., Kile, B. T., & Burt, R. A. (2013). Erratum: Two ENU-induced alleles of atp2b2 cause deafness in mice. PLoS ONE, 8(7).
Scopus22012 Masters, S. L., Gerlic, M., Metcalf, D., Preston, S., Pellegrini, M., O'Donnell, J. A., . . . Croker, B. A. (2012). NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells. Immunity, 37(6), 1009-1023.
Scopus251 WoS207 Europe PMC1912012 Lindqvist, L. M., Vikström, I., Chambers, J. M., McArthur, K., Ann Anderson, M., Henley, K. J., . . . Huang, D. C. S. (2012). Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor. Cell Death and Disease, 3(10), e409-1-e409-9.
Scopus42 WoS34 Europe PMC342012 Zhang, J. G., Czabotar, P. E., Policheni, A. N., Caminschi, I., San Wan, S., Kitsoulis, S., . . . Lahoud, M. H. (2012). The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments. Immunity, 36(4), 646-657.
Scopus260 WoS209 Europe PMC1992012 White, M. J., Schoenwaelder, S. M., Josefsson, E. C., Jarman, K. E., Henley, K. J., James, C., . . . Kile, B. T. (2012). Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function. Blood, 119(18), 4283-4290.
Scopus68 WoS57 Europe PMC482012 Debrincat, M., Josefsson, E., James, C., Henley, K., Ellis, S., Lebois, M., . . . Kile, B. (2012). Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival. Blood, 119(24), 5850-5858.
Scopus72 WoS61 Europe PMC492012 Josefsson, E. C., White, M. J., Dowling, M. R., & Kile, B. T. (2012). Platelet life span and apoptosis. Methods in Molecular Biology, 788, 59-71.
Scopus30 Europe PMC232012 Carpinelli, M. R., Burt, R. A., & Kile, B. T. (2012). Genetic Modifier Screens in Mice.. Current protocols in mouse biology, 2(1), 75-87.
Europe PMC12012 Kauppi, M., Hilton, A. A., Metcalf, D., Ng, A. P., Hyland, C. D., Collinge, J. E., . . . Alexander, W. S. (2012). Thrombocytopenia and erythrocytosis in mice with a mutation in the gene encoding the hemoglobin β minor chain. Proceedings of the National Academy of Sciences of the United States of America, 109(2), 576-581.
Scopus4 WoS3 Europe PMC22012 Kile, B. T. (2012). The spreading influence of platelet HDACs. Blood, 120(20), 4118-4119.
Scopus1 WoS12012 Carmichael, C. L., Metcalf, D., Henley, K. J., Kruse, E. A., Di Rago, L., Mifsud, S., . . . Kile, B. T. (2012). Hematopoietic overexpression of the transcription factor Erg induces lymphoid and erythro-megakaryocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America, 109(38), 15437-15442.
Scopus46 WoS38 Europe PMC372012 Verhagen, A. M., De Graaf, C. A., Baldwin, T. M., Goradia, A., Collinge, J. E., Kile, B. T., . . . Hilton, D. J. (2012). Reduced lymphocyte longevity and homeostatic proliferation in lamin B receptor-deficient mice results in profound and progressive lymphopenia. Journal of Immunology, 188(1), 122-134.
Scopus8 WoS8 Europe PMC92012 Kraemer, B. F., Campbell, R. A., Schwertz, H., Franks, Z. G., De Abreu, A. V., Grundler, K., . . . Weyrich, A. S. (2012). Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets. Blood, 120(25), 5014-5020.
Scopus53 WoS44 Europe PMC392011 Fairfield, H., Gilbert, G. J., Barter, M., Corrigan, R. R., Curtain, M., Ding, Y., . . . Reinholdt, L. G. (2011). Mutation discovery in mice by whole exome sequencing. Genome Biology, 12(9), 12 pages.
Scopus93 WoS87 Europe PMC782011 Josefsson, E. C., James, C., Henley, K. J., Debrincat, M. A., Rogers, K. L., Dowling, M. R., . . . Kile, B. T. (2011). Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets. Journal of Experimental Medicine, 208(10), 2017-2031.
Scopus152 WoS128 Europe PMC1122011 Nguyen, N. Y. N., Maxwell, M. J., Ooms, L. M., Davies, E. M., Hilton, A. A., Collinge, J. E., . . . Curtis, D. J. (2011). An ENU-induced mouse mutant of SHIP1 reveals a critical role of the stem cell isoform for suppression of macrophage activation. Blood, 117(20), 5362-5371.
Scopus15 WoS13 Europe PMC112011 Ng, A. P., Loughran, S. J., Metcalf, D., Hyland, C. D., De Graaf, C. A., Hu, Y., . . . Alexander, W. S. (2011). Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice. Blood, 118(9), 2454-2461.
Scopus45 WoS34 Europe PMC362011 Bishton, M. J., Harrison, S. J., Martin, B. P., McLaughlin, N., James, C., Josefsson, E. C., . . . Johnstone, R. W. (2011). Deciphering the molecular and biologic processes that mediate histone deacetylase inhibitor - Induced thrombocytopenia. Blood, 117(13), 3658-3668.
Scopus131 WoS109 Europe PMC922011 Taoudi, S., Bee, T., Hilton, A., Knezevic, K., Scott, J., Willson, T. A., . . . Hilton, D. J. (2011). ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification. Genes and Development, 25(3), 251-262.
Scopus92 WoS67 Europe PMC702011 Schoenwaelder, S. M., Jarman, K. E., Gardiner, E. E., Hua, M., Qiao, J., White, M. J., . . . Jackson, S. P. (2011). Bcl-x<inf>L</inf>-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets. Blood, 118(6), 1663-1674.
Scopus258 WoS203 Europe PMC1972010 Kelly, P. N., White, M. J., Goschnick, M. W., Fairfax, K. A., Tarlinton, D. M., Kinkel, S. A., . . . Strasser, A. (2010). Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development. Cell Death and Differentiation, 17(10), 1655-1664.
Scopus57 WoS43 Europe PMC432010 Greig, K. T., De Graaf, C. A., Murphy, J. M., Carpinelli, M. R., Pang, S. H. M., Frampton, J., . . . Nutt, S. L. (2010). Critical roles for c-Myb in lymphoid priming and early B-cell development. Blood, 115(14), 2796-2805.
Scopus55 WoS50 Europe PMC502010 Takiguchi, M., James, C., Josefsson, E. C., Carmichael, C. L., Premsrirut, P. K., Lowe, S. W., . . . Dickins, R. A. (2010). Transgenic, inducible RNAi in megakaryocytes and platelets in mice. Journal of Thrombosis and Haemostasis, 8(12), 2751-2756.
Scopus8 WoS8 Europe PMC72010 Ng, A. P., Hyland, C. D., Metcalf, D., Carmichael, C. L., Loughran, S. J., Di Rago, L., . . . Alexander, W. S. (2010). Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome. Blood, 115(19), 3966-3969.
Scopus62 WoS45 Europe PMC472010 Dowling, M. R., Josefsson, E. C., Henley, K. J., Hodgkin, P. D., & Kile, B. T. (2010). Platelet senescence is regulated by an internal timer, not damage inflicted by hits. Blood, 116(10), 1776-1778.
Scopus52 WoS43 Europe PMC352010 White, M. J., & Kile, B. T. (2010). Apoptotic Processes in Megakaryocytes and Platelets. Seminars in Hematology, 47(3), 227-234.
Scopus37 WoS30 Europe PMC282010 Cordell, P. A., Kile, B. T., Standeven, K. F., Josefsson, E. C., Pease, R. J., & Grant, P. J. (2010). Association of coagulation factor XIII-A with Golgi proteins within monocyte-macrophages: Implications for subcellular trafficking and secretion. Blood, 115(13), 2674-2681.
Scopus51 WoS45 Europe PMC422009 Hilton, D. J., Kile, B. T., & Alexander, W. S. (2009). Mutational inhibition of c-Myb or p300 ameliorates treatment-induced thrombocytopenia. Blood, 113(22), 5599-5604.
Scopus7 WoS6 Europe PMC62009 Kruse, E. A., Loughran, S. J., Baldwin, T. M., Josefsson, E. C., Ellis, S., Watson, D. K., . . . Kile, B. T. (2009). Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage. Proceedings of the National Academy of Sciences of the United States of America, 106(33), 13814-13819.
Scopus82 WoS70 Europe PMC602009 Ellett, F., Kile, B. T., & Lieschke, G. J. (2009). The role of the ETS factor erg in zebrafish vasculogenesis. Mechanisms of Development, 126(3-4), 220-229.
Scopus27 WoS24 Europe PMC192009 Rank, G., Sutton, R., Marshall, V., Lundie, R. J., Caddy, J., Romeo, T., . . . Jane, S. M. (2009). Novel roles for erythroid Ankyrin-1 revealed through an ENU-induced null mouse mutant. Blood, 113(14), 3352-3362.
Scopus41 WoS37 Europe PMC362009 Verhagen, A. M., Wallace, M. E., Goradia, A., Jones, S. A., Croom, H. A., Metcalf, D., . . . Starr, R. (2009). A kinase-dead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency. Journal of Immunology, 182(4), 2020-2029.
Scopus16 WoS13 Europe PMC132009 Schoenwaelder, S. M., Yuan, Y., Josefsson, E. C., White, M. J., Yao, Y., Mason, K. D., . . . Jackson, S. P. (2009). Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function. Blood, 114(3), 663-666.
Scopus266 WoS244 Europe PMC2042008 Smyth, I., Hacking, D. F., Hilton, A. A., Mukhamedova, N., Meikle, P. J., Ellis, S., . . . Hilton, D. J. (2008). A mouse model of harlequin ichthyosis delineates a key role for Abca12 in lipid homeostasis. PLoS Genetics, 4(9), 11 pages.
Scopus69 WoS60 Europe PMC522008 Kauppi, M., Murphy, J. M., De Graaf, C. A., Hyland, C. D., Greig, K. T., Metcalf, D., . . . Alexander, W. S. (2008). Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl/mice. Blood, 112(8), 3148-3153.
Scopus27 WoS28 Europe PMC242008 Loughran, S. J., Kruse, E. A., Hacking, D. F., de Graaf, C. A., Hyland, C. D., Willson, T. A., . . . Kile, B. T. (2008). The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells. Nature Immunology, 9(7), 810-819.
Scopus217 WoS186 Europe PMC1762008 Burt, R. A., Joseph, J. E., Milliken, S., Collinge, J. E., & Kile, B. T. (2008). Description of a novel mutation leading to MYH9-related disease. Thrombosis Research, 122(6), 861-863.
Scopus14 WoS14 Europe PMC132007 Kile, B. T., Panopoulos, A. D., Stirzaker, R. A., Hacking, D. F., Tahtamouni, L. H., Willson, T. A., . . . Justice, M. J. (2007). Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia. Blood, 110(7), 2371-2380.
Scopus96 WoS86 Europe PMC702007 Greig, K. T., Antonchuk, J., Metcalf, D., Morgan, P. O., Krebs, D. L., Zhang, J. G., . . . Kile, B. T. (2007). Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development. Molecular and Cellular Biology, 27(16), 5849-5859.
Scopus55 WoS46 Europe PMC432007 Silver, J. D., Hilton, D. J., Bahlo, M., & Kile, B. T. (2007). Probabilistic analysis of recessive mutagenesis screen strategies. Mammalian Genome, 18(1), 5-22.
Scopus5 WoS2 Europe PMC22007 Tucker, E., O'Donnell, K., Fuchsberger, M., Hilton, A. A., Metcalf, D., Greig, K., . . . Starr, R. (2007). A novel mutation in the Nfkb2 gene generates an NF-κB2 "super repressor". Journal of Immunology, 179(11), 7514-7522.
Scopus66 WoS64 Europe PMC592007 Mason, K. D., Carpinelli, M. R., Fletcher, J. I., Collinge, J. E., Hilton, A. A., Ellis, S., . . . Kile, B. T. (2007). Programmed Anuclear Cell Death Delimits Platelet Life Span. Cell, 128(6), 1173-1186.
Scopus870 WoS734 Europe PMC6552007 Debrincat, M. A., Zhang, J. G., Willson, T. A., Silke, J., Connolly, L. M., Simpson, R. J., . . . Hilton, D. J. (2007). Ankyrin repeat and suppressors of cytokine signaling box protein Asb-9 targets creatine kinase B for degradation. Journal of Biological Chemistry, 282(7), 4728-4737.
Scopus44 WoS42 Europe PMC322006 Alexander, W. S., Viney, E. M., Zhang, J. G., Metcalf, D., Kauppi, M., Hyland, C. D., . . . Hilton, D. J. (2006). Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene. Proceedings of the National Academy of Sciences of the United States of America, 103(44), 16442-16447.
Scopus71 WoS61 Europe PMC522005 Kile, B. T., & Hilton, D. J. (2005). The art and design of genetic screens: Mouse. Nature Reviews Genetics, 6(7), 557-567.
Scopus84 WoS71 Europe PMC562003 Kile, B. T., Hentges, K. E., Clark, A. T., Nakamura, H., Salinger, A. P., Liu, B., . . . Justice, M. J. (2003). Functional genetic analysis of mouse chromosome 11. Nature, 425(6953), 81-86.
Scopus185 WoS159 Europe PMC1442003 Kile, B. T., Mason-Garrison, C. L., & Justice, M. J. (2003). Sex and strain-related differences in the peripheral blood cell values of inbred mouse strains. Mammalian Genome, 14(1), 81-85.
Scopus41 WoS36 Europe PMC332002 Kile, B. T., Schulman, B. A., Alexander, W. S., Nicola, N. A., Martin, H. M. E., & Hilton, D. J. (2002). The SOCS box: A tale of destruction and degradation. Trends in Biochemical Sciences, 27(5), 235-241.
Scopus380 WoS338 Europe PMC2592001 Kile, B. T., Metcalf, D., Mifsud, S., DiRago, L., Nicola, N. A., Hilton, D. J., & Alexander, W. S. (2001). Functional analysis of Asb-1 using genetic modification in mice. Molecular and Cellular Biology, 21(18), 6189-6197.
Scopus51 WoS47 Europe PMC382001 Kile, B. T., & Alexander, W. S. (2001). The suppressors of cytokine signalling (SOCS). Cellular and Molecular Life Sciences, 58(11), 1627-1635.
Scopus148 WoS138 Europe PMC1042001 Kile, B. T., Nicola, N. A., & Alexander, W. S. (2001). Negative regulators of cytokine signaling. International Journal of Hematology, 73(3), 292-298.
Scopus63 WoS59 Europe PMC442000 Kile, B. T., Viney, E. M., Willson, T. A., Brodnicki, T. C., Cancilla, M. R., Herlihy, A. S., . . . Alexander, W. S. (2000). Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4. Gene, 258(1-2), 31-41.
Scopus43 WoS42 Europe PMC311999 Cutts, S. M., Fowler, K. J., Kile, B. T., Hii, L. L. P., O'Dowd, R. A., Hudson, D. F., . . . Choo, K. H. A. (1999). Defective chromosome segregation, microtubule bundling and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice. Human Molecular Genetics, 8(7), 1145-1155.
Scopus87 WoS85 Europe PMC651999 Zhang, J. G., Farley, A., Nicholson, S. E., Willson, T. A., Zugaro, L. M., Simpson, R. J., . . . Baca, M. (1999). The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proceedings of the National Academy of Sciences of the United States of America, 96(5), 2071-2076.
Scopus542 WoS506 Europe PMC3621999 Alexander, W. S., Starr, R., Metcalf, D., Nicholson, S. E., Farley, A., Elefanty, A. G., . . . Hilton, D. J. (1999). Suppressors of cytokine signaling (SOCS): Negative regulators of signal transduction. Journal of Leukocyte Biology, 66(4), 588-592.
Scopus107 WoS93 Europe PMC601999 Saffery, R., Irvine, D. V., Kile, B. T., Hudson, D. F., Cutts, S. M., & Choo, K. H. A. (1999). Cloning, expression, and promoter structure of a mammalian inner centromere protein (INCENP). Mammalian Genome, 10(4), 415-418.
Scopus8 WoS8 Europe PMC61998 Fowler, K. J., Saffery, R., Kile, B. T., Irvine, D. V., Hudson, D. F., Trowell, H. E., & Choo, K. H. A. (1998). Genetic mapping of mouse centromere protein (Incenp and Cenpe) genes. Cytogenetics and Cell Genetics, 82(1-2), 67-70.
Scopus5 WoS5 Europe PMC3 -
Book Chapters
Year Citation 2013 Josefsson, E. C., Dowling, M. R., Lebois, M., & Kile, B. T. (2013). The Regulation of Platelet Life Span. In Platelets (pp. 51-65). Elsevier.
DOI Scopus202012 Josefsson, E. C., Dowling, M. R., Lebois, M., & Kile, B. T. (2012). The Regulation of Platelet Life Span. In Platelets, Third Edition (pp. 51-65).
DOI2009 Josefsson, E. C., & Kile, B. T. (2009). Cell death in the hematopoietic system. In Essentials of Apoptosis: A Guide for Basic and Clinical Research (pp. 443-459). Humana Press.
DOI Scopus4 -
Conference Papers
Year Citation 2021 Pang, E. S., Daraj, G., Macri, C., Balka, K., de Nardo, D., Hochrein, H., . . . O'Keeffe, M. (2021). Activation of stimulator of interferon genes in dendritic cells induces interferon-lambda and subset- and species-specific dendritic cell death. In JOURNAL OF IMMUNOLOGY Vol. 206 (pp. 2 pages). AMER ASSOC IMMUNOLOGISTS. 2020 Denorme, F., Manne, B., Kosaka, Y., Majersik, J., Kile, B., Rondina, M., & Campbell, R. (2020). Platelet Cyclophilin D Mediates Neutrophil Recruitment and Ischemic Stroke Outcomes in Mice. In STROKE Vol. 51 (pp. 2 pages). Los Angeles, CA: LIPPINCOTT WILLIAMS & WILKINS. 2019 Denorme, F., Manne, B. K., Kosaka, Y., Kile, B., Rondina, M. T., & Campbell, R. A. (2019). Cyclophilin D Mediated Platelet Necrosis Regulates Ischemic Stroke Outcomes in Mice. In BLOOD Vol. 134 (pp. 4 pages). Orlando, FL: AMER SOC HEMATOLOGY.
DOI2019 Pang, S., Wallis, G., Mendonca, S., Hisana, A., Chappaz, S., Rautela, J., . . . Heng, T. (2019). DISSECTING THE MOLECULAR PATHWAYS OF APOPTOSIS IN MESENCHYMAL STROMAL CELL THERAPY. In CYTOTHERAPY Vol. 21 (pp. S85). ELSEVIER SCI LTD.
DOI2016 Carmichael, C. L., Goossens, S., Wang, J., Thao, N., Haigh, K., Berx, G., . . . Haigh, J. J. (2016). The EMT Modulator SNAI1 Drives AML Development Via Its Interaction with the Chromatin Modulator LSD1. In BLOOD Vol. 128 (pp. 4 pages). San Diego, CA: AMER SOC HEMATOLOGY.
DOI WoS12016 Strassel, C., Hovasse, A., Moog, S., Mageira, M., Batzenschlager, M., Schaeffer-Reiss, C., . . . Lanza, F. (2016). Selected Expression and Functional Importance of alpha 4a-Tubulin in Platelet Biogenesis. In BLOOD Vol. 128 (pp. 3 pages). San Diego, CA: AMER SOC HEMATOLOGY.
DOI2016 Thirant, C., Lopez, C. K., Ignacimouttou, C., Diop, M., Le Mouel, L., Thiollier, C., . . . Mercher, T. (2016). ETO2-GLIS2 Controls Differentiation Arrest and Self-Renewal through Aberrant Enhancers Regulation in Pediatric Leukemia. In BLOOD Vol. 128 (pp. 5 pages). San Diego, CA: AMER SOC HEMATOLOGY.
DOI2015 Pleines, I., Lebois, M., Au, A. E. -L., Lane, R. M., Henley, K. J., Corbin, J., . . . Josefsson, E. C. (2015). Extended Platelet In Vivo Survival Results in Exhausted Platelets. In BLOOD Vol. 126 (pp. 3 pages). Orlando, FL: AMER SOC HEMATOLOGY.
DOI WoS32015 Lebois, M., Dowling, M. R., Hodgkin, P. D., Kile, B. T., Alexander, W. S., & Josefsson, E. C. (2015). Regulation of Platelet Lifespan in the Presence and Absence of TPO Signaling. In BLOOD Vol. 126 (pp. 2 pages). Orlando, FL: AMER SOC HEMATOLOGY. 2015 Keniry, A., Gearing, L., Jansz, N., Liu, J., Kinkel, S., Breslin, K., . . . Blewitt, M. E. (2015). IHSTONE H3 LYSINE 9 METHYLATION IS INVOLVED NOT ONLY IN MAINTAINING EPIGENETIC SILENCING, BUT IS ESSENTIAL FOR SETTING UP GENE SILENCING. In EXPERIMENTAL HEMATOLOGY Vol. 43 (pp. S38). Kyoto, JAPAN: ELSEVIER SCIENCE INC.
DOI2014 Pleines, I., Woods, J., Turro, E., Foad, N., Chappaz, S., Lane, R. M., . . . Kile, B. T. (2014). Mutations in Tropomyosin 4 Cause Macrothrombocytopenia in Mice and Humans. In BLOOD Vol. 124 (pp. 3 pages). AMER SOC HEMATOLOGY.
DOI WoS12014 White, M. J., McArthur, K., Metcalf, D., Cambier, J., Bedoui, S., Ritchie, M., . . . Kile, B. (2014). The apoptotic caspase cascade suppresses mitochondrial DNA-induced STING-mediated type I IFN production by dying cells. In CYTOKINE Vol. 70 (pp. 75-76). Melbourne, AUSTRALIA: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD.
DOI2014 Potts, K., Sargeant, T., Markham, J., Shi, W., Dawson, C., Josefsson, E., . . . Taoudi, S. (2014). IDENTIFICATION OF DIPLOID PLATELET-FORMING CELLS PRIOR TO THE EMERGENCE OF POLYPLOIDY MEGAKARYOCYTE IN THE MOUSE EMBRYO. In EXPERIMENTAL HEMATOLOGY Vol. 42 (pp. S56). Montreal, CANADA: ELSEVIER SCIENCE INC.
DOI2013 Josefsson, E. C., Lebois, M., Cannon, P., Moujalled, D., Rutgersson, A., Faraj, F., . . . Alexander, S. (2013). Role of thrombopoietin signalling in murine B-cell lymphoma. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 509). WILEY-BLACKWELL. 2013 Pleines, I., Chappaz, S., Lane, R., Kostadima, M. A., Schevzov, G., Ghevaert, C., . . . Kile, B. T. (2013). Tropomyosin 4 is a novel regulator of platelet production in mice and humans. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 159-160). WILEY-BLACKWELL. 2013 Carmichael, C., Tang, J. Z., Metcalf, D., Shi, W., Henley, K., Ng, A., . . . Kile, B. (2013). OVEREXPRESSION OF THE ETS-FAMILY TRANSCRIPTION FACTOR ERG AND DYSREGULATED CYTOKINE SIGNALING DRIVE ERYTHROID LEUKEMIA DEVELOPMENT IN MICE. In EXPERIMENTAL HEMATOLOGY Vol. 41 (pp. S21). Vienna, AUSTRIA: ELSEVIER SCIENCE INC.
DOI2013 Kile, B. (2013). THE INTRINSIC APOPTOSIS CASPASE CASCADE REGULATES HEMATOPOIETIC STEM CELL HOMEOSTASIS AND FUNCTION. In EXPERIMENTAL HEMATOLOGY Vol. 41 (pp. S4). Vienna, AUSTRIA: ELSEVIER SCIENCE INC.
DOI WoS12012 Josefsson, E. C., Burnett, D. L., Debrincat, M. A., Henley, K. J., Lane, R. M., Lebois, M., . . . Kile, B. T. (2012). Platelet Production Occurs Independently of Both the Intrinsic and Extrinsic Apoptosis Pathways. In BLOOD Vol. 120 (pp. 2 pages). GA, Atlanta: AMER SOC HEMATOLOGY.
DOI2012 Jessie, E. E., Ruisi, M. M., Green, D., Burt, R., Davis, J., Macatangay, R. A., . . . Bussel, J. B. (2012). Radioulnar Synostosis-Hematology (RUS-H) Syndrome: Description of the New Syndrome and Comparison to Similar Syndromes. In BLOOD Vol. 120 (pp. 2 pages). Atlanta, GA: AMER SOC HEMATOLOGY.
DOI2012 Masters, S. L., Gerlic, M., Metcalf, D., Preston, S. P., Pellegrini, M., O'Donnell, J. A., . . . Kile, B. T. (2012). Activation of the NLRP1 Inflammasome Induces the Pyroptotic Death of Hematopoietic Progenitor Cells. In BLOOD Vol. 120 (pp. 2 pages). GA, Atlanta: AMER SOC HEMATOLOGY.
DOI2012 Carmichael, C. L., Metcalf, D., Henley, K. J., Kruse, E. A., Di Rago, L., Mifsud, S., . . . Kile, B. T. (2012). Hematopoietic Overexpression of the ETS Family Transcription Factor Erg, or the Oncogenic Fusion Protein TLS-ERG, Induces Erythro-Megakaryocytic Leukemia. In BLOOD Vol. 120 (pp. 2 pages). GA, Atlanta: AMER SOC HEMATOLOGY.
DOI2011 Mitchell, W. B., Edison, M. N., Pinheiro, M. P., Boulad, N., Psaila, B., Karpoff, M., . . . Bussel, J. B. (2011). The Effect of Eltrombopag on Platelet Resistance to Apoptosis: The Role of the Bcl-Xl Pathway. In BLOOD Vol. 118 (pp. 524). San Diego, CA: AMER SOC HEMATOLOGY. 2011 Bishton, M. J., Prince, M., Johnstone, R. W., Harrison, S. J., & Kile, B. T. (2011). The Pan Histone Deacetylase Inhibitor Panobinostat and the Iso-Selective Inhibitor Romidepsin Reduce Glycoprotein VI Expression and Inhibit Platelet Activation in Response to Collagen Related Peptide. In BLOOD Vol. 118 (pp. 522-523). San Diego, CA: AMER SOC HEMATOLOGY. 2011 Curtis, D. J., Brown, F., Wiley, J., Ho, S., Hilton, D. J., Kile, B. T., & Jane, S. M. (2011). ENU Mutagenesis in the Mouse for Identification of Genes Regulating Erythropoiesis: a Mouse Mutant with An Activating Mutation of the KCl Cotransporter, KCC1 Causing Dehydrated Red Cells. In BLOOD Vol. 118 (pp. 313-314). San Diego, CA: AMER SOC HEMATOLOGY. 2011 Schoenwaelder, S. M., Jarman, K., Gardiner, E., Qiao, J. L., White, M. J., Josefsson, E. C., . . . Jackson, S. P. (2011). Bcl-x<sub>l</sub> inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 9 (pp. 63). WILEY-BLACKWELL. 2011 Josefsson, E. C., White, M. J., Schoenwaelder, S. M., Jarman, K., Henley, K. J., Lane, R. M., . . . Kile, B. T. (2011). Elucidating the role of the intrinsic apoptosis pathway in platelet function. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 9 (pp. 11). WILEY-BLACKWELL. 2011 Kile, B. T. (2011). Apoptotic processes in megakaryocytes and platelets. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 9 (pp. 1). WILEY-BLACKWELL. 2011 Josefsson, E. C., James, C., Burnett, D., Debrincat, M. A., Henley, K. J., Lane, R., . . . Kile, B. T. (2011). Megakaryocytes possess functional apoptotic pathways that must be restrained in order to survive and produce platelets. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 9 (pp. 322). WILEY-BLACKWELL. 2010 Ruisi, M. M., Jessica, E., Green, D., Oiyemhonlan, B., Shah, S., Kile, B. T., . . . Bussel, J. B. (2010). Radioulnar Synostosis and Its Hematology and Genetic Associations.. In BLOOD Vol. 116 (pp. 1045). Orlando, FL: AMER SOC HEMATOLOGY. 2010 Mitchell, W. B., Edison, M. N., Pinheiro, M. P., Boulad, N., Psaila, B., Karpoff, M., . . . Bussel, J. B. (2010). The Effect of Eltrombopag on Human Platelet Resistance to Apoptosis: The Role of the Bcl-Xl Pathway.. In BLOOD Vol. 116 (pp. 1044). Orlando, FL: AMER SOC HEMATOLOGY. 2010 Josefsson, E. C., James, C., Henley, K. J., Debrincat, M. A., Rogers, K. L., Dowling, M. R., . . . Kile, B. T. (2010). Megakaryocytes Possess a Functional Intrinsic Apoptosis Pathway That Must Be Restrained In Order to Survive and Produce Platelets. In BLOOD Vol. 116 (pp. 244). Orlando, FL: AMER SOC HEMATOLOGY. 2010 Josefsson, E. C., James, C., Henley, K. J., Debrincat, M., Rogers, K. L., Dowling, M. R., . . . Kile, B. T. (2010). MEGAKARYOCYTES POSSESS A FUNCTIONAL INTRINSIC APOPTOSIS PATHWAY, BUT DO NOT USE IT TO PRODUCE PLATELETS. In EXPERIMENTAL HEMATOLOGY Vol. 38 (pp. S36). Melbourne, AUSTRALIA: ELSEVIER SCIENCE INC. 2010 Ng, P., Hyland, C., Metcalf, D., Carmichael, C. L., Loughran, S. J., DiRago, L., . . . Alexander, W. S. (2010). TRISOMY OF ERG IS REQUIRED FOR MYELOPROLIFERATION IN A MOUSE MODEL OF DOWN SYNDROME. In EXPERIMENTAL HEMATOLOGY Vol. 38 (pp. S24-S25). Melbourne, AUSTRALIA: ELSEVIER SCIENCE INC. 2010 Verhagen, A. M., Goradia, A., Choi, J., Metcalf, D., Kile, B., Collinge, J. E., . . . Starr, R. (2010). LYMPHOPENIA AND DEFECTIVE HEMATOPOIESIS IN THE LAMIN B RECEPTOR DEFICIENT ENU MUTANT MOUSE LYM3. In EXPERIMENTAL HEMATOLOGY Vol. 38 (pp. S10). Melbourne, AUSTRALIA: ELSEVIER SCIENCE INC. 2009 Bishton, M. J., Prince, M., Harrison, S., Martin, B. P., James, C., Kile, B. T., & Johnstone, R. W. (2009). Overcoming Histone Deacetylase Inhibitor Induced Thrombocytopenia Using a Thrombopoietin Mimetic. In BLOOD Vol. 114 (pp. 954). New Orleans, LA: AMER SOC HEMATOLOGY. 2009 James, C., Josefsson, E. C., White, M. J., Henley, K. J., & Kile, B. T. (2009). Deletion of <i>Bcl-X</i> in the Megakaryocyte Compartment Results in Profound Thrombocytopenia Caused by Impaired Platelet Production and Survival. In BLOOD Vol. 114 (pp. 601). New Orleans, LA: AMER SOC HEMATOLOGY. 2009 Hacking, D., Hilton, A., Ip, S., Mukhamedova, N., Meikle, P., Ellis, S., . . . Smyth, I. (2009). A role for Abca12 in regulating terminal differentiation and lipid balance in the developing epidermis. In MECHANISMS OF DEVELOPMENT Vol. 126 (pp. S122-S123). Edinburgh, SCOTLAND: ELSEVIER SCIENCE BV.
DOI2009 Sviridov, D., D'Souza, W., Murphy, A., Mukhamedova, N., Chin-Dusting, J., Hacking, D., . . . Smyth, I. (2009). ABCA12-A NEW REGULATOR OF CELLULAR LIPID METABOLISM. In ATHEROSCLEROSIS SUPPLEMENTS Vol. 10 (pp. 1 page). ELSEVIER IRELAND LTD. 2009 Kile, B. T. (2009). The role of the intrinsic apoptosis pathway in platelet life and death. In Journal of Thrombosis and Haemostasis Vol. 7 (pp. 214-217). Boston, MA: WILEY.
DOI Scopus59 WoS55 Europe PMC382008 Josefsson, E. C., Schoenwaelder, S., White, M., Goschnick, M., Roberts, A. W., Mason, K. D., . . . Kile, B. T. (2008). Platelet Death. In BLOOD Vol. 112 (pp. 1352-1353). San Francisco, CA: AMER SOC HEMATOLOGY. 2007 Tucker, E., O'Donnell, K., Hilton, A. A., Metcalf, D., Greig, K., Sims, N. A., . . . Starr, R. (2007). A novel mutation in the <i>Nfkb2</i> gene generates an NFκB2 'Super repressor'. In CYTOKINE Vol. 39 (pp. 43). San Francisco, CA: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD.
DOI2007 Mason, K. D., Carpinelli, M. R., Fletcher, J. I., Collinge, J. E., Hilton, A. A., Metcalf, D., . . . Huang, D. D. C. S. (2007). The delicate balance between pro survival BCL XL and pro apoptotic BAK determines platelet life span. In EXPERIMENTAL HEMATOLOGY Vol. 35 (pp. 33). Hamburg, GERMANY: ELSEVIER SCIENCE INC.
WoS3
2018-2021 DHB Foundation managed by ANZ Trustees. The development of small molecule inhibitors of cell death. $800,000. CIA: BT Kile, CIB: G Lessene.
2017-2021 NHMRC Program Grant No. 1113577: Regulation of Haemopoietic and Immune Cells in Health and Disease. $19,924,985. CIA: WS Alexander, CIB: JJ Babon, CIC: MC Cook, CID: DJ Hilton, CIE: BT Kile, CIF: NA Nicola, CIG: AW Roberts, CIH: CG Vinuesa, CII: IP Wicks.
2015-2018 NHMRC Project Grant No. 1077750: The role of apoptotic caspases in regulating type I interferon production. $761,513. CIA: BT Kile, CIB: M Pellegrini.
2014-2018 NHMRC Principal Research Fellowship No. 1063008. $727,610. CI: BT Kile.
2014-2017 DHB Foundation managed by ANZ Trustees. The development of small molecule inhibitors of cell death. $650,000. CIA: BT Kile, CIB: G Lessene.
2013 Leukaemia Foundation of Australia Research Grant-in-aid. Elucidation of the mechanisms involved in the development of erythromegakaryocytic leukaemia driven by the proto-oncogene ETS-related gene ERG. $100,000. CIA: CL Carmichael, CIB: BT Kile.
2012-2016 NHMRC Program Grant No. 1016647: Molecular regulation of blood cell production and function. $17,100,000. CIA: NA Nicola, CIB: WS Alexander, CIC: DJ Hilton, CID: D Metcalf, CIE: AW Roberts, CIF: JG Zhang, CIG: SE Nicholson, CIH: BT Kile, CII: IP Wicks.
2011-2013 NHMRC Project Grant No. 1002426: Defining the role of Nlrp1 and the inflammasome in host defence and inflammatory disease. $612,561. CIA: BT Kile, CIB: B Croker, CIC: SL Masters.
2009-2011 NHMRC Project Grant No. 545906: The role of the ABCA12 transporter in epidermal lipid homeostasis and atherosclerosis. $496,250. CIA: I Smyth, CIB: D Sviridov, CIC: BT Kile.
2009-2011 NHMRC Project Grant No. 575535: Bcl-2 proteins and the regulation of the megakaryocyte lineage. $399,900. CIA: BT Kile, CIB: C James.
2009-2013 Sylvia & Charles Viertel Foundation Senior Medical Research Fellowship. $975,000. CI: BT Kile.
2008-2010 NHMRC Project Grant No. 516726: Role of the Ets family transcription factor Erg in stem cell function and leukemia development. $397,125 CIA: BT Kile.
2008-2010 NHMRC Project Grant No. 516725: The molecular regulation of platelet life span. $521,000. CIA: BT Kile, CIB: SP Jackson, CIC: AW Roberts.
2007-2011 Cancer Council of Victoria Venture Grant No. Scanning the genome for new drug targets in cancer CIA: WS Alexander, CIB: BT Kile, CIC: A Strasser. 2007-2011. $244,500.
2007-2009 NHMRC Project Grant No. 461247: The genetic control of platelet production and function. $537,000 CIA: BT Kile, CIB: WS Alexander, CIC: HH Nandurkar.
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