Belinda Di Bartolo
Adelaide Medical School
Faculty of Health and Medical Sciences
Belinda completed her PhD in 2009 at the Heart Research Institute in Sydney. In 2011 she was awarded an NHMRC Early Career Training Fellowship to undertake research at the Centre for Vascular Research. Belinda joined SAHMRI mid-way through 2015 as a Senior Post Doctoral Fellow and her current research interests include the effect of lipids and lipid-lowering therapies on the process of vascular inflammation and calcification in heart disease and diabetes. She currently leads the Vascular Inflammation group in the Heart Health Theme at SAHMRI.
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Appointments
Date Position Institution name 2015 Afflliate University of Adelaide 2015 Senior Post Doctoral Fellow South Australian Health and Medical Research Institute, Adelaide 2014 - 2015 Affiliate University of Sydney, Sydney 2014 - 2015 Senior Post Doctoral Researcher The Heart Research Institute 2009 - 2014 Post Doctoral Researcher The University of New South Wales -
Awards and Achievements
Date Type Title Institution Name Country Amount 2017 Award Tom Simpson Trust Fund Award Heart Foundation — — 2017 Award Australian Atherosclerosis Society Trust Award — — — 2015 Award ATVB Junior Investigator for Women Finalist — — — 2014 Award ATVB Young Investigator Finalist American Heart Association — — 2014 Award Best Post Doctoral Poster Presentation ISCP State of the Heart – Australian Vascular Biology Society — — 2013 Award Best Poster Award European Atherosclerosis Society — — 2012 Award Best Post Doctoral Poster Presentation Australian Vascular Biology Society — — 2012 Fellowship Early Career Fellowship – Peter Doherty Award NHMRC — — 2011 Award Post Doctoral Travel Award University of New South Wales — — 2011 Award Young Investigator Award Asia-Pacific Society of Atherosclerosis and Vascular Diseases (APSAVD) Congress — — 2011 Award Best Post Doctoral Oral presentation Australian Vascular Biology Society — — 2010 Award BioAssayLINK Award Australian Atherosclerosis Society — — 2010 Award Young Investigator Award Australian Atherosclerosis Society — — 2010 Award Post Doctoral Travel Award University of New South Wales — — 2009 Award Young Investigator Award XV International Symposium on Atherosclerosis — — 2009 Award Student Travel Award National Heart Foundation, Australia — — 2009 Award Student Travel Award Australian Atherosclerosis Society — — -
Language Competencies
Language Competency English Can read, write, speak, understand spoken and peer review -
Education
Date Institution name Country Title 2006 - 2009 University of Sydney, Sydney Australia PhD — University of Sydney, Sydney Australia BMedSc -
Research Interests
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Journals
Year Citation 2021 Pisaniello, A. D., Psaltis, P. J., King, P. M., Liu, G., Gibson, R. A., Tan, J. T., . . . Di Bartolo, B. A. (2021). Omega-3 fatty acids ameliorate vascular inflammation: A rationale for their atheroprotective effects.. Atherosclerosis, 324, 27-37.
2020 Cartland, S. P., Tamer, N., Patil, M. S., Di Bartolo, B. A., & Kavurma, M. M. (2020). A "Western Diet" promotes symptoms of hepatic steatosis in spontaneously hypertensive rats. International Journal of Experimental Pathology, 101(5), 152-161.
Europe PMC12020 Hansen, T., Galougahi, K. K., Besnier, M., Genetzakis, E., Tsang, M., Finemore, M., . . . Figtree, G. A. (2020). The novel P2X7 receptor antagonist PKT100 improves cardiac function and survival in pulmonary hypertension by direct targeting of the right ventricle. American Journal of Physiology - Heart and Circulatory Physiology, 319(1), H183-H191.
Scopus1 WoS2 Europe PMC22020 Kott, K. A., Vernon, S. T., Hansen, T., de Dreu, M., Das, S. K., Powell, J., . . . Figtree, G. A. (2020). Single-Cell Immune Profiling in Coronary Artery Disease: The Role of State-of-the-Art Immunophenotyping With Mass Cytometry in the Diagnosis of Atherosclerosis. Journal of the American Heart Association, 9(24), e017759.
Europe PMC12019 Toledo-Flores, D., Williamson, A., Schwarz, N., Fernando, S., Dimasi, C., Witt, T. A., . . . Psaltis, P. J. (2019). Vasculogenic properties of adventitial Sca-1+CD45+ progenitor cells in mice: a potential source of vasa vasorum in atherosclerosis. Scientific Reports, 9(1), 15 pages.
Scopus5 WoS5 Europe PMC12019 Akers, E. J., Nicholls, S. J., & Di Bartolo, B. A. (2019). Plaque calcification: Do lipoproteins have a role?. Arteriosclerosis, Thrombosis, and Vascular Biology, 39(10), 1902-1910.
Scopus8 WoS7 Europe PMC62019 Takata, K., Honda, S., Sidharta, S. L., MyNgan, D., Shishikura, D., Kim, S. W., . . . Nicholls, S. J. (2019). Associations of ABCG1-mediated cholesterol efflux capacity with coronary artery lipid content assessed by near-infrared spectroscopy. CARDIOVASCULAR DIAGNOSIS AND THERAPY, 9(4), 310.
Scopus3 WoS3 Europe PMC22018 Cannizzo, C. M., Adonopulos, A. A., Solly, E. L., Ridiandries, A., Vanags, L. Z., Mulangala, J., . . . Tan, J. T. (2018). VEGFR2 is activated by high-density lipoproteins and plays a key role in the proangiogenic action of HDL in ischemia. FASEB Journal, 32(6), 2911-2922.
Scopus6 WoS6 Europe PMC42018 Takata, K., Di Bartolo, B., & Nicholls, S. (2018). High-Density Lipoprotein Infusions. Cardiology Clinics, 36(2), 311-315.
Scopus1 WoS12018 Andrews, J., Psaltis, P., Bartolo, B., Nicholls, S., & Puri, R. (2018). Coronary arterial calcification: A review of mechanisms, promoters and imaging. Trends in Cardiovascular Medicine, 28(8), 491-501.
Scopus18 WoS16 Europe PMC72018 Di Bartolo, B., & Straub, A. (2018). Highlights from vascular discovery: From genes to medicine scientific sessions 2018. Journal of the American Heart Association, 7(15), 3 pages.
2018 Di Bartolo, B., Psaltis, P., Bursill, C., & Nicholls, S. (2018). Translating evidence of HDL and plaque regression. Arteriosclerosis, thrombosis, and vascular biology, 38(9), 1961-1968.
Scopus10 WoS12 Europe PMC52017 Di Bartolo, B., Schwarz, N., Andrews, J., & Nicholls, S. (2017). Infusional high-density lipoproteins therapies as a novel strategy for treating atherosclerosis. Archives of Medical Science, 13(1), 210-214.
Scopus4 WoS3 Europe PMC32017 Di Bartolo, B., Scherer, D. J., Brown, A., Psaltis, P. J., & Nicholls, S. J. (2017). PCSK9 Inhibitors in Hyperlipidemia: Current Status and Clinical Outlook. BioDrugs, 31(3), 167-174.
Scopus7 WoS7 Europe PMC52017 Cartland, S., Harith, H., Genner, S., Dang, L., Cogger, V., Vellozzi, M., . . . Kavurma, M. (2017). Non-alcoholic fatty liver disease, vascular inflammation and insulin resistance are exacerbated by TRAIL deletion in mice. Scientific Reports, 7(1), 1898-1-1898-12.
Scopus22 WoS23 Europe PMC122017 Di Bartolo, B., & Nicholls, S. (2017). Anacetrapib as a potential cardioprotective strategy. Drug Design, Development and Therapy, 11, 3497-3502.
Scopus3 WoS4 Europe PMC12016 Di Bartolo, B., Scherer, D., & Nicholls, S. (2016). Inducing apolipoprotein A-I synthesis to reduce cardiovascular risk: From ASSERT to SUSTAIN and beyond. Archives of Medical Science, 12(6), 1302-1307.
Scopus12 WoS11 Europe PMC72016 Di Bartolo, B., Takata, K., Duong, M., & Nicholls, S. (2016). CETP Inhibition in CVD prevention: an actual appraisal. Current Cardiology Reports, 18(5), 43-1-43-6.
Scopus11 WoS11 Europe PMC82016 Di Bartolo, B., Duong, M., & Nicholls, S. (2016). Clinical trials with cholesteryl ester transfer protein inhibitors. Current Opinion in Lipidology, 27(6), 545-549.
Scopus11 WoS12 Europe PMC72016 Harith, H., Di Bartolo, B., Cartland, S., Genner, S., & Kavurma, M. (2016). Insulin promotes vascular smooth muscle cell proliferation and apoptosis via differential regulation of tumor necrosis factor-related apoptosis-inducing ligand. Journal of Diabetes, 8(4), 568-578.
Scopus6 WoS6 Europe PMC32015 Duong, M., Di Bartolo, B., & Nicholls, S. (2015). Acute high-density lipoprotein therapies. Current Opinion in Lipidology, 26(6), 521-525.
Scopus2 WoS22015 Di Bartolo, B. A., Cartland, S. P., Prado-Lourenco, L., Griffith, T. S., Gentile, C., Ravindran, J., . . . Kavurma, M. M. (2015). Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes angiogenesis and ischemia-induced neovascularization via NADPH oxidase 4 (NOX4) and nitric oxide-dependent mechanisms. Journal of the American Heart Association, 4(11), e002527-1-e002527-16.
Scopus27 WoS25 Europe PMC172014 Di Bartolo, B., & Kavurma, M. (2014). Regulation and function of RANKL in arterial calcification. Current Pharmaceutical Design, 20(37), 5853-5861.
Scopus6 WoS5 Europe PMC22013 Di Bartolo, B., Cartland, S., Harith, H., Bobryshev, Y., Schoppet, M., & Kavurma, M. (2013). TRAIL-deficiency accelerates vascular calcification in atherosclerosis via modulation of RANKL. PLoS ONE, 8(9), e74211-1-e74211-9.
Scopus40 WoS37 Europe PMC272012 Azahri, N., Di Bartolo, B., Khachigian, L., & Kavurma, M. (2012). Sp1, acetylated histone-3 and p300 regulate TRAIL transcription: mechanisms of PDGF-BB-mediated VSMC proliferation and migration. Journal of Cellular Biochemistry, 113(8), 2597-2606.
Scopus27 WoS30 Europe PMC212011 Di Bartolo, B., Chan, J., Bennett, M., Cartland, S., Bao, S., Tuch, B., & Kavurma, M. (2011). TNF-related apoptosis-inducing ligand (TRAIL) protects against diabetes and atherosclerosis in Apoe -/- mice. Diabetologia, 54(12), 3157-3167.
Scopus82 WoS80 Europe PMC652011 Di Bartolo, B., Vanags, L., Tan, J., Bao, S., Rye, K., Barter, P., & Bursill, C. (2011). The apolipoprotein A-I mimetic peptide, ETC-642, reduces chronic vascular inflammation in the rabbit.. Lipids in health and disease, 10(1), 224.
Scopus18 WoS18 Europe PMC122011 Di Bartolo, B., Nicholls, S., Bao, S., Rye, K., Heather, A., Barter, P., & Bursill, C. (2011). The apolipoprotein A-I mimetic peptide ETC-642 exhibits anti-inflammatory properties that are comparable to high density lipoproteins. Atherosclerosis, 217(2), 395-400.
Scopus40 WoS41 Europe PMC322011 Di Bartolo, B., Schoppet, M., Mattar, M., Rachner, T., Shanahan, C., & Kavurma, M. (2011). Calcium and osteoprotegerin regulate IGF1R expression to inhibit vascular calcification. Cardiovascular Research, 91(3), 537-545.
Scopus30 WoS31 Europe PMC192010 Patel, S., Di Bartolo, B. A., Nakhla, S., Heather, A. K., Mitchell, T. W., Jessup, W., . . . Rye, K. A. (2010). Anti-inflammatory effects of apolipoprotein A-I in the rabbit. Atherosclerosis, 212(2), 392-397.
Scopus56 WoS55 Europe PMC472010 Chan, J., Prado-Lourenco, L., Khachigian, L. M., Bennett, M. R., Di Bartolo, B. A., & Kavurma, M. M. (2010). TRAIL promotes VSMC proliferation and neointima formation in a FGF-2-, Sp1 Phosphorylation-, and NFκB-Dependent Manner. Circulation Research, 106(6), 1061-1071.
Scopus61 WoS59 Europe PMC422009 Peshavariya, H., Dusting, G. J., Di Bartolo, B., Rye, K. A., Barter, P. J., & Jiang, F. (2009). Reconstituted high-density lipoprotein suppresses leukocyte NADPH oxidase activation by disrupting lipid rafts. Free Radical Research, 43(8), 772-782.
Scopus27 WoS24 Europe PMC152009 McGrath, K. C. Y., Li, X. H., Puranik, R., Liong, E. C., Tan, J. T. M., Dy, V. M., . . . Heather, A. K. (2009). Role of 3β-hydroxysteroid-Δ24 reductase in mediating antiinflammatory effects of high-density lipoproteins in endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 29(6), 877-882.
Scopus70 WoS69 Europe PMC492006 Nicholls, S., Lundman, P., Harmer, J., Cutri, B., Griffiths, K., Rye, K., . . . Celermajer, D. (2006). Consumption of saturated fat impairs the anti-inflammatory properties of high-density lipoproteins and endothelial function. Journal of the American College of Cardiology, 48(4), 715-720.
Scopus156 WoS146 Europe PMC952006 Cutri, B. A., Hime, N. J., & Nicholls, S. J. (2006). High-density lipoproteins: An emerging target in the prevention of cardiovascular disease. Cell Research, 16(10), 799-808.
Scopus21 WoS21 Europe PMC132005 Nicholls, S., Cutri, B., Worthley, S., Kee, P., Rye, K., Bao, S., & Barter, P. (2005). Impact of short-term administration of high-density lipoproteins and atorvastatin on atherosclerosis in rabbits. Arteriosclerosis Thrombosis and Vascular Biology, 25(11), 2416-2421.
Scopus131 WoS125 Europe PMC952005 Nicholls, S., Dusting, G., Cutri, B., Bao, S., Drummond, G., Rye, K., & Barter, P. (2005). Reconstituted high-density lipoproteins inhibit the acute pro-oxidant and proinflammatory vascular changes induced by a periarterial collar in normocholesterolemic rabbits. Circulation, 111(12), 1543-1550.
Scopus235 WoS220 Europe PMC176 -
Book Chapters
Year Citation 2019 Nicholls, S., Akers, E., & Di Bartolo, B. (2019). Vascular calcification in response to pharmacological interventions. In A. V. Finn (Ed.), Coronary Calcium: A Comprehensive Understanding of Its Biology, Use in Screening, and Interventional Management (pp. 181-189). London, United Kingdom: Academic Press.
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Conference Papers
Year Citation 2019 Pisaniello, A. D., King, P., Di Bartolo, B. A., Liu, G., Gibson, R. A., Tan, J. T. M., . . . Nicholls, S. (2019). IMPACT OF FISH OIL SUPPLEMENTATION ON ACUTE VASCULAR INFLAMMATION IN HEALTHY VOLUNTEERS. In JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY Vol. 73 (pp. 2091). New Orleans, LA: ELSEVIER SCIENCE INC.
2018 Akers, E. J., Mulangala, J., Psaltis, P. J., Bursill, C., Nicholls, S. J., & Di Bartolo, B. A. (2018). Lipoproteins and their Modified Forms Regulate Smooth Muscle Cell Calcification. In ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY Vol. 38 (pp. 2 pages). San Francisco, CA: LIPPINCOTT WILLIAMS & WILKINS.
2018 Mulangala, J., Akers, E. J., Solly, E. L., Psaltis, P. J., Tan, J. T., Nicholls, S. J., . . . Di Bartolo, B. A. (2018). Elevated Calcium Drives Inflammatory-Driven Angiogenesis. In ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY Vol. 38 (pp. 2 pages). San Francisco, CA: LIPPINCOTT WILLIAMS & WILKINS.
2017 Takata, K., Honda, S., Sidharta, S., Duong, M., Shishikura, D., Kim, S., . . . Nicholls, S. J. (2017). Association between cholesterol efflux capacity and coronary plaque lipid composition on near infrared spectroscopy. In EUROPEAN HEART JOURNAL Vol. 38 (pp. 467). OXFORD UNIV PRESS. 2008 Di Bartolo, B. A., Bao, S., Rye, K. -A., Nicholls, S. J., & Barter, P. J. (2008). In vivo properties of a novel apolipoprotein A-1 mimetic peptide. In JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY Vol. 51 (pp. A283). Chicago, IL: ELSEVIER SCIENCE INC. -
Conference Items
Year Citation 2020 Pisaniello, A. D., Di Bartolo, B. A., Liu, G., King, P. M., Gibson, R. A., Tan, J. T. M., & Nicholls, S. J. (2020). EICOSAPENTAENOIC ACID AMELIORATES VASCULAR INFLAMMATION: A MECHANISTIC RATIONALE FOR ITS ATHEROPROTECTIVE EFFECTS. Poster session presented at the meeting of JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. Chicago, IL: ELSEVIER SCIENCE INC. 2019 Akers, E., Mulangala, J., Wilsdon, L., Psaltis, P., Bursill, C., Nicholls, S., & Di Bartolo, B. (2019). LIPOPROTEINS AND THEIR MODIFIED FORMS REGULATE EARLY STAGE VASCULAR SMOOTH MUSCLE CELL CALCIFICATION. Poster session presented at the meeting of ATHEROSCLEROSIS. Maastricht, NETHERLANDS: ELSEVIER IRELAND LTD.
2019 Akers, E. J., Mulangala, J., Wilsdon, L. A., Psaltis, P. J., Bursill, C. A., Nicholls, S. J., & Di Bartolo, B. A. (2019). Lipoproteins and Their Modified Forms Regulate Early Stage Vascular Smooth Muscle Cell Calcification. Poster session presented at the meeting of ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. Boston, MA: LIPPINCOTT WILLIAMS & WILKINS. 2017 Pisaniello, A., Di Bartolo, B., Liu, G., Gibson, R., Kim, S., Psaltis, P., & Nicholls, S. (2017). THE IMPACT OF ORAL OMEGA-3 FATTY ACID SUPPLEMENTATION ON ACUTE VASCULAR INFLAMMATION IN A MOUSE MODEL. Poster session presented at the meeting of ATHEROSCLEROSIS. Prague, CZECH REPUBLIC: ELSEVIER IRELAND LTD.
2017 Takata, K., Duong, M., Kim, S., Di Bartolo, B., Butters, J., Mani, P., . . . Nicholls, S. J. (2017). GREATER CIRCULATING CONCENTRATIONS OF LARGE HDL PARTICLES ASSOCIATE WITH MORE FAVORABLE HDL FUNCTIONALITY IN YOUNG ADULTS. Poster session presented at the meeting of ATHEROSCLEROSIS. Prague, CZECH REPUBLIC: ELSEVIER IRELAND LTD.
2017 Mulangala, J., Akers, E. J., Psaltis, P. J., Nicholls, S. J., & Di Bartolo, B. A. (2017). Calcium Dose Dependently Influences Endothelial Cell Angiogenesis. Poster session presented at the meeting of ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. Minneapolis, MN: LIPPINCOTT WILLIAMS & WILKINS.
2016 National Heart Foundation Ahrens Grant for 2016 $65000
2014 University of Sydney Early Career Research Grant $25000 for 2015
2011 NHMRC Early Career Fellowship – Peter Doherty Award 2012-2017
2011 University of New South Wales Post Doctoral Small Grant Program $10,000
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2017 Co-Supervisor Role of HDL in diabetes impaired angiogenesis and vascular calcification Doctor of Philosophy Doctorate Full Time Ms Jocelyne Mulangala 2017 Co-Supervisor The role of HDL in vascular calcification and atherosclerosis Doctor of Philosophy Doctorate Full Time Miss Emma Jill Akers -
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2017 - 2019 Co-Supervisor The Impact Of Omega-3 Fatty Acids On Inflammatory Pathways In The Vessel Wall That Promote Atherosclerosis Doctor of Philosophy Doctorate Full Time Dr Anthony David Pisaniello
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