Basira Najafzadeh Sotoubadi

Miss Basira Najafzadeh Sotoubadi

Higher Degree by Research Candidate

PhD Candidates

South Australian Immunogenomics Cancer Institute

Faculty of Health and Medical Sciences

Investigating a role for NF-KB inhibition in overcoming therapeutic resistance to EGFR TKIs in lung cancer: Lung cancer is the leading cause of cancer deaths worldwide. Mutations in the epidermal growth factor receptor (EGFR) gene are one of the most commonly observed mutations in patients with non-small cell lung cancer (NSCLC). Multiple generations of EGFR tyrosine kinase inhibitors (TKIs) have provided significant benefit to clinical outcomes of patients with NSCLC, however resistance and/or disease recurrence almost always occurs. NF-KB signalling is known to be upregulated in EGFR TKI-resistant NSCLC, and preclinical studies have demonstrated that NF-KB inhibition may provide an additional survival benefit when combined with EGFR TKIs. The aim of this project is to identify the cellular mechanisms by which NF-KB upregulation occurs in EGFR-TKI resistance in NSCLC, and to investigate whether NFKB can be targeted in pre-clinical animal models of NSCLC to overcome this.

  • Journals
    Year Citation
    2023 Ghorbaninezhad, F., Alemohammad, H., Najafzadeh, B., Masoumi, J., Shadbad, M. A., Shahpouri, M., . . . Baradaran, B. (2023). Dendritic cell-derived exosomes: A new horizon in personalized cancer immunotherapy?. Cancer Letters, 562, 216168.
    DOI
    2023 Vasefifar, P., Najafi, S., Motafakkerazad, R., Amini, M., Safaei, S., Najafzadeh, B., . . . Baradaran, B. (2023). Targeting Nanog expression increased Cisplatin chemosensitivity and inhibited cell migration in Gastric cancer cells. Experimental Cell Research, 429(2), 113681.
    DOI
    2022 Alemohammad, H., Motafakkerazad, R., Asadzadeh, Z., Farsad, N., Hemmat, N., Najafzadeh, B., . . . Baradaran, B. (2022). siRNA-mediated silencing of Nanog reduces stemness properties and increases the sensitivity of HepG2 cells to cisplatin. Gene, 821, 146333.
    DOI
    2022 Vasefifar, P., Motafakkerazad, R., Maleki, L. A., Najafi, S., Ghrobaninezhad, F., Najafzadeh, B., . . . Baradaran, B. (2022). Nanog, as a key cancer stem cell marker in tumor progression. Gene, 827, 146448.
    DOI
    2022 Najafzadeh, B., Motafakkerazad, R., Najafi, S., Amini, M., Alemohammad, H., Vasefifar, P., & Baradaran, B. (2022). Nanog suppression enhanced the chemosensitivity of human non-small-cell lung cancer cells to Cisplatin and inhibited cell migration. Pathology - Research and Practice, 233, 153869.
    DOI
    2022 Alemohammad, H., Najafzadeh, B., Asadzadeh, Z., Baghbanzadeh, A., Ghorbaninezhad, F., Najafzadeh, A., . . . Baradaran, B. (2022). The importance of immune checkpoints in immune monitoring: A future paradigm shift in the treatment of cancer. Biomedicine & Pharmacotherapy, 146, 112516.
    DOI
    2021 Najafzadeh, B., Asadzadeh, Z., Motafakker Azad, R., Mokhtarzadeh, A., Baghbanzadeh, A., Alemohammad, H., . . . Baradaran, B. (2021). The oncogenic potential of NANOG: An important cancer induction mediator. Journal of Cellular Physiology, 236(4), 2443-2458.
    DOI
    2021 Hemmat, N., Asadzadeh, Z., Ahangar, N. K., Alemohammad, H., Najafzadeh, B., Derakhshani, A., . . . Baradaran, B. (2021). The roles of signaling pathways in SARS-CoV-2 infection; lessons learned from SARS-CoV and MERS-CoV. Archives of Virology, 166(3), 675-696.
    DOI
    2020 Alemohammad, H., Asadzadeh, Z., Motafakker azad, R., Hemmat, N., Najafzadeh, B., Vasefifar, P., . . . Baradaran, B. (2020). Signaling pathways and microRNAs, the orchestrators of NANOG activity during cancer induction. Life Sciences, 260, 118337.
    DOI
    - Ghorbaninezhad, F., Leone, P., Alemohammad, H., Najafzadeh, B., Nourbakhsh, N., Prete, M., . . . Baradaran, B. (n.d.). Tumor necrosis factor‑α in systemic lupus erythematosus: Structure, function and therapeutic implications (Review). International Journal of Molecular Medicine, 49(4).
    DOI

I am a language teacher of English, Persian (Farsi), Turkish, and Azeri.

  • Position: PhD Candidates
  • Email: basira.najafzadehsotoubadi@adelaide.edu.au
  • Campus: West End Health Precinct
  • Building: AHMS - Adelaide Health and Medical Sciences
  • Org Unit: Faculty of Health and Medical Sciences
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