Senior Lecturer - Small Animal Medicine
School of Animal and Veterinary Science
Faculty of Sciences
I am a veterinary scientist with long-standing interests in the biology of cancer, using rodent models to investigate basic cell and molecular biology aspects. Since my appointment to the School of Animal and Veterinary Sciences 8 years ago, I have applied this interest to clinical veterinary oncology research and in the last 3 years have discontinued work with rodent models. My interests are broad, and include for example the molecular underpinnings of feline-specific insecticide sensitivity, chemotherapy for canine osteosarcoma, comparative molecular features of mast cell neoplasia in animals, and inherited blood disorders of dogs. Developing a reliable evidence base for the practise of veterinary medicine depends in part on accurate knowledge of the epidemiology of inherited and acquired conditions affecting the animal population. I am a member of a large collaborative project using VetCompass Australia's centralized, automated, real-time Australia-wide clinical data collection system, that is starting to yield epidemiologic insights into companion animal health and disease.
Date Position Institution name 2017 Clinical Lead University of Adelaide 2017 Associate Professor, Companion Animal Medicine University of Adelaide 2016 Associate Head, Academic University of Adelaide 2011 - 2016 Senior Lecturer University of Adelaide 2006 - 2010 Research Scientist Jackson Laboratory 2004 - 2005 Post-doctoral research fellow University of Sydney 2000 - 2004 Postdoctoral Research Associate Jackson Laboratory 1989 - 1992 Resident, Oncology Service University of California-Davis
Awards and Achievements
Date Type Title Institution Name Country Amount 2015 Research Award Australian Companion Animal Health Foundation 015-2015 University of Adelaide Australia $9,900 2015 Research Award Australian Research Council LEIF application LE160100026 University of Adelaide Australia — 2011 Research Award Congressionally Directed medical Research Program, Department of Defense, BC101296 University of Adelaide Australia — 2008 Research Award National Institutes of Health R21CA1202-04 The Jackson Laboratory, Bar Harbor, Maine United States — 2006 Research Award Susan G Komen for the Cure The Jackson Laboratory, Bar Harbor, Maine United States $250,000 2006 Research Award The Jackson Laboratory Cancer Center Pilot and Feasibility Studies The Jackson Laboratory, Bar Harbour, Maine United States $15,000 2000 Fellowship C.J.Martin Fellow The Jackson Laboratory, Bar Harbor, Maine United States — 1996 Scholarship Sydney Children's Hospital Foundation The University of New South Wales Australia — 1995 Research Award Australian Companion Animal Health Foundation Project award The University of Sydney Australia — 1994 Scholarship Australian Postgraduate Award The University of New South Wales Australia — 1991 Research Award Robert H. Winn Foundation The University of California-Davis — — 1990 Research Award Robert H. Winn Foundation Project Grant The University of California-Davis United States — 1989 Research Award Veterinary Medical Teaching Hospital Resident Research Grant The University of California-Davis United States — 1988 Scholarship Postgraduate Foundation in Veterinary Science Scholarship The University of Sydney Australia —
Language Competency English Can read, write, speak, understand spoken and peer review
Date Institution name Country Title 1993 - 1998 University of New South Wales Australia PhD 1974 - 1979 University of Sydney Australia Bachelor of Veterinary Science
Date Title Institution Country — C.J.Martin Research Fellow National Health and Medical Research Council Australia — Fellow, Internal medicine subspecialty Veterinary Oncology Australian and New Zealand College of Veterinary Scientists Australia — Diplomate, Veterinary Oncology American College of Veterinary Internal Medicine United States — Diploma in Veterinary Clinical Studies University of Sydney Australia
Date Title Institution name Country — Specialist Veterinary Medicine (Oncology) Veterinary Surgeons Board SA —
Year Citation 2020 Tamlin, V. S., Bottema, C. D., & Peaston, A. E. (2020). Comparative aspects of mast cell neoplasia in animals and the role of KIT in prognosis and treatment.. Veterinary medicine and science, 6(1), 3-18.
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2020 Pandarangga, P., Cahyono, M., McAllister, M., Peaston, A., Tearle, R., Low, W., . . . Hemmatzadeh, F. (2020). Full-Genome Sequences of Two Newcastle Disease Virus Strains Isolated in West Java, Indonesia.. Microbiology resource announcements, 9(24).
2020 Esther Yip, H., Peaston, A., Woolford, L., Khuu, S., Wallace, G., Kumar, R., . . . Hemmatzadeh, F. (2020). Diagnostic challenges in Canine Parvovirus 2c in vaccine failure cases. Viruses, 12(9).
2019 Zhou, S., Tearle, R., Jozani, R. J., Winra, B., Schaaf, O., Nicholson, A., & Peaston, A. (2019). Genetic cause for congenital methemoglobinemia in an Australian Pomeranian dog. Journal of Veterinary Internal Medicine, 33(2), 868-873.
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2019 Hemmatzadeh, F., Niap, F., Bennett, B., Trott, D., & Peaston, A. (2019). A novel quantitative polymerase chain reaction to monitor urinary tract mycoplasma infection in a dog. Letters in Applied Microbiology, 68(5), 409-414.
2019 McGreevy, P., Masters, S., Richards, L., Soares Magalhaes, R., Peaston, A., Combs, M., . . . Wilson, B. (2019). Identification of microchip implantation events for dogs and cats in the vetcompass Australia database. Animals, 9(7), 423-1-423-10.
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2019 Tamlin, V., Dobson, E., Woolford, L., & Peaston, A. (2019). DNA purification increases PCR-amplifiable DNA extracted from formalin-fixed, paraffin-embedded canine mast cell tumors for routine KIT mutation detection. Journal of Veterinary Diagnostic Investigation, 31(5), 5 pages.
2019 Endo-Munoz, L., Bennett, T. C., Topkas, E., Wu, S. Y., Thamm, D. H., Brockley, L., . . . Saunders, N. A. (2019). Auranofin improves overall survival when combined with standard of care in a pilot study involving dogs with osteosarcoma.. Veterinary and comparative oncology, 18(2), 206-213.
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2017 Tamlin, V., Kessell, A., McCoy, R., Dobson, E., Smith, T., Hebart, M., . . . Peaston, A. (2017). Prevalence of exon 11 internal tandem duplications in the C-KIT proto-oncogene in Australian canine mast cell tumours. Ausralian Veterinary Journal, 95(10), 386-391.
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2017 McGreevy, P., Thomson, P., Dhand, N., Raubenheimer, D., Masters, S., Mansfield, C., . . . Hammond, J. (2017). VetCompass Australia: A national big data collection system for veterinary science. Animals, 7(10), 74-1-74-15.
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2016 Hasan, N., Ebrahimie, E., Ignjatovic, J., Tarigan, S., Peaston, A., & Hemmatzadeh, F. (2016). Epitope mapping of avian influenza m2e protein: different species recognise various epitopes. PLoS One, 11(6), e0156418-1-e0156418-15.
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2016 Hasan, N., Ignjatovic, J., Peaston, A., & Hemmatzadeh, F. (2016). Avian influenza virus and DIVA strategies. Viral Immunology, 29(4), 198-211.
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2016 Hasan, N., Ebrahimie, E., Ignjatovic, J., Tarigan, S., Peaston, A., & Hemmatzadeh, F. (2016). Antigenic mapping for determining the immunoreactivity of different regions of M2e protein of H5N1 influenza using overlapping peptides-based ELISA. PLoS One. 2016 Peaston, A. E., Smith, T. S., & Howarth, G. S. (2016). Methylation, Retrotransposition-driven Gene Expression and Mammary Cancer. Cancer Science. 2016 Niap, F., Bennett, B. A., Hemmatzadeh, F., Trott, D. J., & Peaston, A. E. (2016). Use of Quantitative polymerase chain reaction to monitor urinary tract mycoplasma infection in a dog. Austraian Veterinary Journal. 2013 Chew, T., Peaston, A., Lim, A., Lorthongpanich, C., Knowles, B., & Solter, D. (2013). A tudor domain protein SPINDLIN1 interacts with the mRNA-binding protein SERBP1 and is involved in mouse oocyte meiotic resumption. PLoS One, 8(7), 1-10.
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2008 Naxerova, K., Bult, C., Peaston, A., Fancher, K., Knowles, B., Kasif, S., & Kohane, I. (2008). Analysis of gene expression in a developmental context emphasizes distinct biological leitmotifs in human cancers. Genome Biology, 9(7), 108 (19 pages).
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2008 Peaston, A. (2008). GADD45 and DNA demethylation [letter]. PLoS Genetics, 4(3), 1-3. 2007 Peaston, A., Knowles, B., & Hutchison, K. (2007). Genome plasticity in the mouse oocyte and early embryo. Biochemical Society Transactions, 35(3), 618-622.
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2006 Peaston, A., & Whitelaw, E. (2006). Epigenetics and phenotypic variation in mammals. Mammalian Genome, 17(5), 365-374.
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2004 Peaston, A., Eviskov, A., Graber, J., de Vries, W., Holbrook, A., Soltor, D., & Knowles, B. (2004). Retrotransposons regulate host genes in mouse oocytes and preimplantation embryos. Developmental Cell, 7(4), 597-606.
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2004 Hansford, L., Thomas, W., Keating, J., Burkhart, C., Peaston, A., Norris, M., . . . Marshall, G. (2004). Mechanisms of embryonal tumor initiation: Distinct roles for MycN expression and MYCN amplification. Proceedings of the National Academy of Sciences of the United States of America, 101(34), 12664-12669.
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2004 Evsikov, A., De Vries, W., Peaston, A., Radford, E., Fancher, K., Chen, F., . . . Knowles, B. (2004). Systems biology of the 2-cell mouse embryo. Cytogenetic and Genome Research, 105(2-4), 240-250.
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2001 Peaston, A., Gardaneh, M., Franco, A., Hocker, J., Murphy, K., Farnsworth, M., . . . Marshall, G. (2001). MRP1 gene expression level regulates the death and differentiation response of neuroblastoma cells. British Journal of Cancer, 85(10), 1564-1571.
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1999 Peaston, A., & Maddison, J. (1999). Efficacy of doxorubicin as an induction agent for cats with lymphosarcoma. Australian Veterinary Journal, 77(7), 442-444.
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1998 Peaston, A., CaMacHo, M., Norris, M., Haber, M., Marsh, D., Robinson, B., . . . Marshall, G. (1998). Absence of MEN2A- or 2B-type RET mutations in primary neuroblastoma tumour tissue. Molecular and Cellular Probes, 12(4), 239-242.
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1997 Court, E., Watson, A., & Peaston, A. (1997). Retrospective study of 60 cases of feline lymphosarcoma. Australian Veterinary Journal, 75(6), 424-427.
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1997 Pittman, S., Geyp, M., Fraser, M., Ellem, K., Peaston, A., & Ireland, C. (1997). Multiple centrosomal microtubule organising centres and increased microtubule stability are early features of VP-16-induced apoptosis in CCRF-CEM cells. Leukemia Research, 21(6), 491-499.
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1997 Marshall, G., Peaston, A., Hocker, J., Smith, S., Hansford, L., Tobias, V., . . . Hancock, J. (1997). Expression of multiple endocrine neoplasia 2B RET in neuroblastoma cells alters cell adhesion in Vitro, enhances metastatic behavior in Vivo, and activates Jun kinase. Cancer Research, 57(23), 5399-5405.
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1997 Watson, A., Peaston, A., Malik, R., & Swinney, G. (1997). Guidelines for handling antineoplastic and immunosuppressive drugs.. Australian veterinary journal, 75(12), 868-876.
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1995 PEASTON, A., & WATSON, A. (1995). A SURVEY ON VETERINARY CLINICAL ONCOLOGY. AUSTRALIAN VETERINARY PRACTITIONER, 25(1), 2-7.
1995 PEASTON, A., & MADDISON, J. (1995). Treatment of superficial tumours on horses with dimethyl sulfoxide and cisplatin. Australian Veterinary Journal, 72(2), 76-77.
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1995 Peaston, A. (1995). Cytosine arabinoside in the treatment of lymphoma in dogs. Australian Veterinary Journal, 72(9), 340.
1994 Leach, M., & Peaston, A. (1994). Adverse Drug Reaction Attributable to Aluminum Phthalocyanine Tetrasulphonate Administration in Domestic Cats. Veterinary Pathology, 31(2), 283-287.
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1994 MADDISON, J., PEASTON, A., & CHURCH, D. (1994). TREATMENT OF 42 CASES OF CANINE LYMPHOSARCOMA WITH COMBINATION CHEMOTHERAPY - 1987-1993. AUSTRALIAN VETERINARY PRACTITIONER, 24(2), 94-&.
1994 PEASTON, A. (1994). CHEMOTHERAPY FOR CANINE APPENDICULAR OSTEOSARCOMA, AND OTHER TREATMENT OPTIONS. AUSTRALIAN VETERINARY PRACTITIONER, 24(3), 136-139. 1994 Théon, A., Peaston, A., Madewell, B., & Dungworth, D. (1994). Irradiation of nonlymphoproliferative neoplasms of the nasal cavity and paranasal sinuses in 16 cats.. Journal of the American Veterinary Medical Association, 204(1), 78-83.
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1994 Peaston, A., & Griffey, S. (1994). Visceral mast cell tumour with eosinophilia and eosinophilic peritoneal and pleural effusions in a cat.. Australian veterinary journal, 71(7), 215-217.
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1993 Peaston, A., Munn, R., & Madewell, B. (1993). Clinical vignette. A 7-year-old Bernese Mountain dog with anemia.. Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, 7(2), 101-103.
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1993 Ogilvie, G., Moore, A., Obradovich, J., Elmslie, R., Vail, D., Straw, R., . . . Withrow, S. (1993). Toxicoses and efficacy associated with administration of mitoxantrone to cats with maligant tumors. Journal of the American Veterinary Medical Association, 202(11), 1839-1844.
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1993 Peaston, A., Leach, M., & Higgins, R. (1993). Photodynamic therapy for nasal and aural squamous cell carcinoma in cats.. Journal of the American Veterinary Medical Association, 202(8), 1261-1265.
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1993 Peaston, A. (1993). Sporotrichosis.. Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, 7(1), 44-45.
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1993 MARKS, S., FARMAN, C., & PEASTON, A. (1993). Nodular Dermatofibrosis and Renal Cystadenomas in a Golden Retriever. Veterinary Dermatology, 4(3), 133-137.
1992 Peaston, A., Higgins, R., Naydan, D., & Sokol, K. (1992). Evaluation of commercially available antibodies to cytokeratin intermediate filaments and laminin in normal cat pinna.. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 4(3), 306-311.
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1990 Peaston, A., Church, D., Allen, G., & Haigh, S. (1990). Combined chylothorax, chylopericardium, and cranial vena cava syndrome in a dog with thymoma.. Journal of the American Veterinary Medical Association, 197(10), 1354-1356.
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Year Citation 2010 Peaston, A., Graber, J., Knowles, B., & de Vries, W. (2010). Interrogating the transcriptome of oocytes and preimplantation embryos. In P. Wassarman, & P. Soriano (Eds.), Guide to Techniques in Mouse Development, Part B (Methods in Enzymology, Volume 477) (Vol. 477, 1 ed., pp. 481-510). Burlington, USA: Academic Press.
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2008 Dobson, J., Hohenhaus, A., & Peaston, A. (2008). Cancer chemotherapy. In J. Maddison, S. Page, & D. Church (Eds.), Small Animal Clinical Pharmacology (2 ed., pp. 330-366). Edinburgh: Elsevier Saunders.
2008 Peaston, A. (2008). Retrotransposons of vertebrates. In B. W. Mahy, & M. REGENMORTEL (Eds.), Encyclopedia of Virology, Five-Volume Set (pp. 436-445). Academic Press.
Year Citation 2013 Peaston., Reichel., & Cockcroft. (2013). o Effect of a core course in research on veterinary student perceptions of research as a career option. In Annual Conference Australian Veterinary Association 2013. Cairns Queensland Australia. 2005 Solter, D., Evsikov, A., Peaston, A., de Vries, W., Holbrook, A., & Knowles, B. (2005). The oocyte as a reprogramming milieu.. In BIOLOGY OF REPRODUCTION (pp. 72). Ctr Rech Biol Reproduct, Quebec City, CANADA: SOC STUDY REPRODUCTION. 2004 Solter, D., Hiiragi, T., Evsikov, A., Moyer, J., De Vries, W., Peaston, A., & Knowles, B. (2004). Epigenetic mechanisms in early mammalian development. In Cold Spring Harbor Symposia on Quantitative Biology Vol. 69 (pp. 11-17). Cold Spring Harbor, NY: COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT.
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2003 Knowles, B., Evsikov, A., De Vries, W., Peaston, A., & Solter, D. (2003). Molecular control of the oocyte to embryo transition. In Philosophical Transactions of the Royal Society B: Biological Sciences Vol. 358 (pp. 1381-1388). ROYAL SOC, LONDON, ENGLAND: ROYAL SOC LONDON.
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- Australian Research Council LEIF application LE160100026, Research Award, VetCompass: big data and real-time surveillance for veterinary science, University of Adelaide, 2015
- Australian Companion Animal Health Foundation 015-2015, Research Award, Prevalence of c-Kit activating mutations in mast cell tumours from Australian dogs, University of Adelaide, 2015- 2017 - $9,900
- Congressionally Directed medical Research Program, Department of Defense, BC101296, Research Award, Mammary Cancer and Activation of Transposable Elements, University of Adelaide, 2011- 2015
- National Institutes of Health R21CA1202-04, Research Award, Mammary Cancer Stem Cells - development of a mouse model for analysis of cancer-predisposed cells at preclinical stages, The Jackson Laboratory, Bar Harbor, Maine, 2008- 2010
- The Jackson Laboratory Cancer Center Pilot and Feasibility Studies, Research Award, Mammary Cancer Stem Cells - a project to genetically label a specific population of these cells with a selectable marker for fate mapping, The Jackson Laboratory, Bar Harbour, Maine, 2006- 2007, $15,000
- Susan G Komen for the Cure, Research Award, Mammary Cancer Stem Cells - development of a mouse model for analysis of cancer-predisposed cells at preclinical stages, The Jackson Laboratory, Bar Harbor, Maine, 2006-2008, $250,000
- Australian Companion Animal Health Foundation Project award, Research Award, Feline Lymphosarcoma Clinical Trial (AVOG 9441), The University of Sydney, 1995- 1996
I teach principles and practise of clinical and basic comparative oncology, veterinary clinical haematology, and pharmacology of chemotherapy agents used in veterinary oncology to DVM1 and DVM2 students. From time to time I teach other aspects of companion animal veterinary internal medicine such as diseases of the respiratory, nervous and urinary systems. My students (one or two per year) excel in the DVM1 Clinical Research Course, and their work is instrumental in setting up different research projects. Much of my teaching is in small groups in the Companion Animal Health Center on the Roseworthy Campus.
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2018 Co-Supervisor Molecular and Immunology Studies on Newly Emerged NDV in Indonesia Doctor of Philosophy Doctorate Full Time Ms Putri Pandarangga
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2016 - 2020 Co-Supervisor KIT Mutations in Australian Canine Mast Cell Tumours and Correlations with Patient Prognostic Factors Doctor of Philosophy Doctorate Full Time Miss Vanessa Tamlin 2013 - 2017 Co-Supervisor Avian Influenza Virus M2e Protein: Epitope Mapping, Competitive ELISA and Phage Displayed scFv for DIVA in H5N1 Serosurveillance Doctor of Philosophy Doctorate Full Time Miss Noor Haliza Hasan
Date Role Board name Institution name Country 2016 - ongoing Board Member VetCompass Board VetCompass Australia Australia
Date Role Committee Institution Country 2017 - ongoing Member Veterinary Health Centres Advisory Committee The University of Adelaide Australia 2015 - ongoing Chair Learning and Teaching Management Committee University of Adelaide, School of Animal and Veterinary Sciences Australia
Date Role Membership Country 1995 - ongoing Member American College of Veterinary Internal Medicine United States 1994 - ongoing Member Australian and New Zealand College of Veterinary Scientists Australia 1990 - ongoing Member Veterinary Cancer Society United States
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