Annabel Sorby-Adams

Annabel Sorby-Adams

Higher Degree by Research Candidate

Adelaide Medical School

Faculty of Health and Medical Sciences


Annabel is a current PhD Candidate and Member of the Translational Neuropathology Laboratory and Stroke Research Program within the School of Medicine at the University of Adelaide, South Australia. Her research is also affiliated with the Adelaide Center for Neuroscience Research, NeuroSurgical Research Foundation and the Peter Couche Foundation

Stroke is the second leading cause of death and leading cause of adult disability worldwide. The development of brain swelling and subsequent rise in brain pressure are life-threatening complications of stroke, for which current treatments are ineffective. This is largely due to the fact that existing treatments target symptoms rather than the underlying cause of the swelling.

A promising novel therapy, the NK1-antagonist has been shown to be efficacious in reducing swelling in pre-clinical models when assessed at 24hrs. However, the evolution of brain swelling and pressure beyond this point are unknown, which has implications for treatment.

My research aims to determine the temporal profile of swelling and pressure changes in the brain following stroke and determine the optimal time window for treatment and to assess the long term efficacy of the NK1 antagonist.

 

https://www.youtube.com/watch?v=FQd7JBJFmXE

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  • Appointments

    Date Position Institution name
    2016 Tutor The University of Adelaide
    2014 Laboratory Demonstrator The University of Adelaide
  • Awards and Achievements

    Date Type Title Institution Name Country Amount
    2016 Award Australasian Neuroscience Society Travel Award Australasian Neuroscience Society Inc
    2016 Scholarship Australian Postgraduate Award The University of Adelaide
    2016 Scholarship Peter Couche Foundation Supplementary Scholarship The Peter Couche Foundation Australia
    2015 Award Highest Aggregate Grade in Major: Pathology (School of Medicine) The University of Adelaide Australia
    2015 Award Highest Aggregate Grade in Subject: Essentials of Pathology (School of Medicine) The University of Adelaide Australia
    2015 Award Highest Aggregate Grade in Subject: Integrative Physiology (School of Medicine) The University of Adelaide Australia
    2015 Award Bachelor of Health Sciences, Executive Dean's Certificate of Merit The University of Adelaide Australia
  • Education

    Date Institution name Country Title
    2016 - 2019 University of Adelaide Australia PhD in Medicine
    2015 - 2015 University of Adelaide Australia Bachelor of Health Sciences (Honours)
    2011 - 2014 The University of Adelaide Australia Bachelor of Health Sciences
  • Research Interests

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  • Journals

    Year Citation
    2019 Sorby-Adams, A. J., Leonard, A., Elms, L. E., Marian, O. C., Hoving, J. W., Yassi, N., . . . Turner, R. J. (2019). Determining the temporal profile of intracranial pressure changes following transient stroke in an ovine model. Frontiers in Neuroscience, 13(JUL), 587-1-587-16.
    DOI
    2019 Sorby-Adams, A. J., Leonard, A., Hoving, J. W., Yassi, N., Vink, R., Wells, A. J., & Turner, R. J. (2019). NK1-r antagonist treatment comparable to decompressive craniectomy in reducing intracranial pressure following stroke. Frontiers in Neuroscience, 13(JUL), 681-1-681-12.
    DOI Scopus1 WoS1 Europe PMC1
    2018 Sorby-Adams, A., Vink, R., & Turner, R. (2018). Large animal models of stroke and traumatic brain injury as translational tools. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 315(2), 165-190.
    DOI Scopus10 WoS9 Europe PMC7
    2017 Sorby-Adams, A., Marcoionni, A., Dempsey, E., Woenig, J., & Turner, R. (2017). The role of neurogenic inflammation in blood-brain barrier disruption and development of cerebral oedema following acute central nervous system (CNS) injury. International Journal of Molecular Sciences, 18(8), 24 pages.
    DOI Scopus13 WoS10 Europe PMC4
  • Conference Items

    Year Citation
    2017 Sorby-Adams, A., Leonard, A., Thornton, E., Hunter, D., & Turner, R. (2017). Delayed NK1 tachykinin receptor antagonist treatment reduces ICP following stroke in an Ovine model. Poster session presented at the meeting of JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. Int Soc Cerebral Blood Flow & Metab, Berlin, GERMANY: SAGE PUBLICATIONS INC.
    2015 Sorby-Adams, A. J. (2015). Determining the temporal profile of cerebral oedema and elevated intracranial pressure following transient Ovine MCA occlusion. Poster session presented at the meeting of Australian Annual Neurotrauma Forum.

Peter Couche Foundation Supplementary Scholarisgip Recipient
January 2016

Australian Postgraduate Award Scholarship Recipient
January 2016

Medicine and Medical Sciences
Lecturer, Tutor and Marker Neurological Diseases III (PATHOL 3200)
Lecturer, Tutor and Marker Essentials of Neuroscience I (HLTH SC 1001)
Tutor and Demonstrator Functional Human Neuroanatomy III (ANAT SC 3103)
Demonstrator Foundations of Human Neuroanatomy (ANAT SC 2006)
Demonstrator and Marker Essentials of Pathology III (PATHOL 3003)
Demonstrator Cells, Tissues and Development II (ANAT SC 2109)

Nursing
Tutor Biology of Human Disease I (NURSING 2005)
Marker Biology of Human Disease II (NURSING 2008)


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