Ankit Parikh

Dr Ankit Parikh

PIDG Business Development and Projects Officer

School of Pharmacy and Biomedical Science

College of Health

Ankit is a pharmaceutical academic scientist with research experience centred around translational pharmaceutical science. His research interest is concerned with the utilization of drug delivery science for the development of challenging therapeutics for a preclinical and clinical study. He has proven track record in developing drug delivery systems for neurological disorders, cancer and infectious diseases, and veterinary formulations. Moreover, he has supervised 21 research students at various levels. My papers are in high impact factor journals including Proceedings of the National Academy of Sciences, Drug Delivery, International Journal of Pharmaceutics, Drug Design, Development, and Therapy, Drug Delivery, and Translational Research and journal of pharmaceutical sciences.
A number of actives and formulations from his research group have reached from lab to clinical trials and market. During PhD study, he has developed two patented technologies (patent number: CN107308133A and WO2017157350A1) which has been licenced to Biotech company Suzhou Auzone and WuxiAPPtec, China. Currently, they have invested US$4 million to develop into the drug for the treatment of and Alzheimer’s disease, ischemic stroke, and amyotrophic lateral sclerosis (ALS) (IND will be filed in the middle of 2019). Furthermore, he was also involved in industry-sponsored project (Bova Australia and UK) for development, technology transfer and scale-up of patented lipid-based long-acting formulations (Patent number: WO2017096426A1) for treating gastric ulcers.  Currently, the equine product has established a new benchmark in the treatment of equine gastric ulcers and is the first product to have a high level of clinical success in thousands of horses in the UK and Australia.
 My main duties in the pharmaceutical lab include.
·         Development and validation of analytical methods using HPLC with UV-visible, PDA, Fluorescence and evaporative light scattering detector (ELSD), LC/MS-MS, UV-Visible spectrometer, Fluorescence spectrophotometer and ELISA technique. 
·         Preformulation study including solubility study, stability study (Hydrolysis, Oxidative, Photolytic, Thermal, with Plasma, excipient compatibility, and packaging material compatibility).
·         Formulation development, and optimization of novel drug delivery system including Nanotechnology-based formulation including Micelles, Lipid-based formulations such as self-microemulsifying drug delivery systems (SMEDDS), Solid Lipid Nanoparticles and Nanostructured Lipid Carriers, Polymeric nanoparticles, Nanosuspension; Microparticles, Solid Dispersion, In-situ gel with aqueous and non- aqueous base.
·         Formulation development, and optimization of conventional drug delivery system including solid dosage form like Tablet including sustained or controlled release and fast dissolving, Capsule; liquid dosage form like Suspension, and solution with aqueous and non- aqueous base, and emulsion; and Semi-solid dosage form like ointment, cream, and gel with aqueous and non- aqueous base.
·         Formulation development and optimisation Oral including Baccal, Parenteral including IV, IM and SC, Topical, Transdermal and Pulmonary administration. 
·         Characterization of developed formulation including dissolution study with USP Type 2 units, Franz cell and dialysis bags, disintegration study, hardness, Zetasizer, DSC study, XRD study, SEM study, TEM study, NMR study, and stability study as per ICH guideline.
·         In-vivo evaluation of the performance of formulation including Pharmacokinetic study, Safety and efficacy study with normal and disease mice and rat models.
·         Maintain daily comprehensive records of work performed and results of studies.
·         Write applications for animal ethics and human ethics boards.
·         Participate in preparing grant applications for categories 1, 2 and 3.
·         Preparing peer reviewed journal articles.
·         Attend meetings, seminars and conferences.
·         Support the group in meeting objectives of publishing and dissemination of research outcomes through preparation of peer reviewed journal articles and conference papers for submission.
·         Mentor or Supervise PhD, master and honours degree students, interns and visiting scholars.
My key achievements include,
·         Best Poster Award for title "Development of Novel Curcumin Formulation (NCF) for Cancer and Alzheimer Disease" for 2017 HDR Research Poster Competition at University of South Australia.
·         Best Poster Award for title "Formulation, Optimization and Characterization of lipid nanoparticles of Clioquinol for Alzheimer's disease" for 2015 Division of Health Sciences Research Showcase at University of South Australia.
·         Featured as an Enterprising Faces in a special edition of Enterprise magazine and Research edge magazine of the University of South Australia in 2015.
·         Featured in the worldwide media release of my research (>30 science news alert) in 2015.
·         Recipient of Young Innovator Scientist Award for title "Long lasting in situ injectable depot preparation" for Young Innovators Choice Competition 2011 organised by Institute of Chemical Technology, India.
·         Best Paper Award for title "Toxicokinetics: A stupendous approach in drug discovery" at national conference on “Drug Discovery: PK-PD Perspective"2011 organised at Nirma University, India.
·         Best Poster Award for title" Toxicokinetics: A stupendous approach pharmacoinformatics" for state level symposium Pharmaescapade 2011 organised at Sigma Institute of Pharmacy, India.
·         Best paper Award for title "Novel Targeted drug delivery systems - new age weapons for bladder diseases" for International level online competition Pharmashine-2011 organised by PharmaTutor and Organization of Pharmaceutical Unity with BioAllied Sciences (OPUBS), India.
·         Best Poster Award for title" Novel drug delivery systems for protein and peptide drugs delivery" for state level symposium Pharmaescapade 2010 organised at Sigma Institute of Pharmacy, India.
·         Best Poster Award for title" Biohydrogen: A boon for mankind" for National level Symposium (Chemozale 2009) organised at Nirma University, India.       
·         Awarded merit-based free registration to the 12th Quality in Postgraduate Research (QPR) Conference in 2017.
·         Recipient of Travel Grant sponsored by Fujian Kangshimei Co, China in 2016.
·         Recipient of HDR Travel Grant from University of South Australia in 2016.
·         Recipient of AICTE PG Scholarship for conducting Master by research course work.

My research is particularly focused on the development of drug delivery systems for neurological disorders, cancer and infectious diseases, targeted drug delivery, specialized formulations for superbugs, extemporaneous compounding, and veterinary formulations that are capable to deliver modern and safe medicine to the community. 

My main duties in the pharmaceutical lab include.

·         Development and validation of analytical methods using HPLC with UV-visible, PDA, Fluorescence and evaporative light scattering detector (ELSD), LC/MS-MS, UV-Visible spectrometer, Fluorescence spectrophotometer and ELISA technique. 

·         Preformulation study including solubility study, stability study (Hydrolysis, Oxidative, Photolytic, Thermal, with Plasma, excipient compatibility, and packaging material compatibility).

·         Formulation development, and optimization of novel drug delivery system including Nanotechnology-based formulation including Micelles, Lipid-based formulations such as self-microemulsifying drug delivery systems (SMEDDS), Solid Lipid Nanoparticles and Nanostructured Lipid Carriers, Polymeric nanoparticles, Nanosuspension; Microparticles, Solid Dispersion, In-situ gel with aqueous and non- aqueous base.

·         Formulation development, and optimization of conventional drug delivery system including solid dosage form like Tablet including sustained or controlled release and fast dissolving, Capsule; liquid dosage form like Suspension, and solution with aqueous and non- aqueous base, and emulsion; and Semi-solid dosage form like ointment, cream, and gel with aqueous and non- aqueous base.

·         Formulation development and optimisation Oral including Baccal, Parenteral including IV, IM and SC, Topical, Transdermal and Pulmonary administration. 

·         Characterization of developed formulation including dissolution study with USP Type 2 units, Franz cell and dialysis bags, disintegration study, hardness, Zetasizer, DSC study, XRD study, SEM study, TEM study, NMR study, and stability study as per ICH guideline.

·         In-vivo evaluation of the performance of formulation including Pharmacokinetic study, Safety and efficacy study with normal and disease mice and rat models.

·         Maintain daily comprehensive records of work performed and results of studies.

·         Write applications for animal ethics and human ethics boards.

·         Participate in preparing grant applications for categories 1, 2 and 3.

·         Preparing peer reviewed journal articles.

·         Attend meetings, seminars and conferences.

·         Support the group in meeting objectives of publishing and dissemination of research outcomes through preparation of peer reviewed journal articles and conference papers for submission.

·         Mentor or Supervise PhD, master and honours degree students, interns and visiting scholars.

Year Citation
2023 Abid, F., Savaliya, B., Parikh, A., Kim, S., Amirmostofian, M., Cesari, L., . . . Garg, S. (2023). Nanotechnology and narasin: a powerful combination against acne.. Nanoscale, 15(33), 13728-13739.
DOI Scopus8 WoS7 Europe PMC5
2023 Choudhury, H., Pandey, M., Saravanan, V., Mun, A. T. Y., Bhattamisra, S. K., Parikh, A., . . . Gorain, B. (2023). Recent progress of targeted nanocarriers in diagnostic, therapeutic, and theranostic applications in colorectal cancer. Biomaterials Advances, 153(213556), 28 pages.
DOI Scopus9 WoS8 Europe PMC6
2022 Shrivastava, N., Parikh, A., Dewangan, R. P., Biswas, L., Verma, A. K., Mittal, S., . . . Baboota, S. (2022). Solid Self-Nano Emulsifying Nanoplatform Loaded with Tamoxifen and Resveratrol for Treatment of Breast Cancer. Pharmaceutics, 14(7), 34 pages.
DOI Scopus38 WoS32 Europe PMC16
2022 Abid, F., Youssef, S. H., Song, Y., Parikh, A., Trott, D., Page, S. W., & Garg, S. (2022). Development and validation of a new analytical method for estimation of narasin using refractive index detector and its greenness evaluation. Microchemical Journal, 175(article no. 107149), 1-7.
DOI Scopus10 WoS10
2022 Zhao, L. Q., Parikh, A., Xiong, Y. X., Ye, Q. Y., Ying, G., Zhou, X. F., & Luo, H. Y. (2022). Neuroprotection of oral edaravone on middle cerebral artery occlusion in rats. Neurotoxicity Research, 40(4), 995-1006.
DOI Scopus6 WoS5 Europe PMC4
2021 Arafat, M., Fouladian, P., Wignall, A., Song, Y., Parikh, A., Albrecht, H., . . . Blencowe, A. (2021). Development and in vitro evaluation of 5-fluorouracil-eluting stents for the treatment of colorectal cancer and cancer-related obstruction. Pharmaceutics, 13(1), 1-22.
DOI Scopus23 WoS20 Europe PMC11
2021 Arafat, M., Song, Y., Brewer, K., Fouladian, P., Parikh, A., Albrecht, H., . . . Garg, S. (2021). Pharmaceutical development of 5-fluorouracil- eluting stents for the potential treatment of gastrointestinal cancers and related obstructions. Drug Design Development and Therapy, 15, 1495-1507.
DOI Scopus8 WoS9 Europe PMC5
2020 Pansara, C., Mishra, R., Mehta, T., Parikh, A., & Garg, S. (2020). Formulation of chitosan stabilized silver nanoparticle-containing wound healing film: in-vitro and in-vivo characterization. Journal of Pharmaceutical Sciences, 109(7), 2196-2205.
DOI Scopus56 WoS53 Europe PMC25
2020 Vitali, D., Bagri, P., Wessels, J. M., Arora, M., Ganugula, R., Parikh, A., . . . Kaushic, C. (2020). Curcumin can decrease tissue inflammation and the severity of HSV-2 infection in the female reproductive mucosa. International Journal of Molecular Sciences, 21(1), 19 pages.
DOI Scopus49 WoS41 Europe PMC31
2020 Muta, T., Parikh, A., Kathawala, K., Haidari, H., Song, Y., Thomas, J., & Garg, S. (2020). Quality-by-design approach for the development of nano-sized tea tree oil formulation-impregnated biocompatible gel with antimicrobial properties. Pharmaceutics, 12(11), 1-16.
DOI Scopus23 WoS22 Europe PMC11
2020 Kelliny, S., Lam, H. Y., Parikh, A., Wang, Y. J., Bobrovskaya, L., Upton, R., & Zhou, X. F. (2020). Preclinical study of the pharmacokinetics of p75ECD-Fc, a novel human recombinant protein for treatment of Alzheimer’s disease, in Sprague Dawley rats. Current Drug Metabolism, 21(3), 235-244.
DOI Scopus8 WoS7 Europe PMC7
2019 Pansara, C., Chan, W. Y., Parikh, A., Trott, D. J., Mehta, T., Mishra, R., & Garg, S. (2019). Formulation optimization of chitosan-stabilized silver nanoparticles using in vitro antimicrobial assay. Journal of Pharmaceutical Sciences, 108(2), 1007-1016.
DOI Scopus29 WoS26 Europe PMC8
2019 Afinjuomo, F., Barclay, T. G., Parikh, A., Song, Y., Chung, R., Wang, L., . . . Garg, S. (2019). Design and characterization of inulin conjugate for improved intracellular and targeted delivery of pyrazinoic acid to monocytes. Pharmaceutics, 11(5), 243-1-243-22.
DOI Scopus13 WoS9 Europe PMC9
2019 Afinjuomo, F., Barclay, T. G., Parikh, A., Chung, R., Song, Y., Nagalingam, G., . . . Garg, S. (2019). Synthesis and characterization of pH-sensitive inulin conjugate of isoniazid for monocyte-targeted delivery. Pharmaceutics, 11(11), 555-1-555-19.
DOI Scopus21 WoS20 Europe PMC10
2019 Wang, L., Song, Y., Parikh, A., Joyce, P., Chung, R., Liu, L., . . . Garg, S. (2019). Doxorubicin-loaded delta inulin conjugates for controlled and targeted drug delivery: development, characterization, and in vitro evaluation. Pharmaceutics, 11(11), 581-1-581-17.
DOI Scopus30 WoS25 Europe PMC19
2019 Afinjuomo, F., Barclay, T. G., Song, Y., Parikh, A., Petrovsky, N., & Garg, S. (2019). Synthesis and characterization of a novel inulin hydrogel crosslinked with pyromellitic dianhydride. Reactive and Functional Polymers, 134, 104-111.
DOI Scopus62 WoS51
2019 Afinjuomo, F., Fouladian, P., Parikh, A., Barclay, T. G., Song, Y., & Garg, S. (2019). Preparation and characterization of oxidized inulin hydrogel for controlled drug delivery. Pharmaceutics, 11(7), 21 pages.
DOI Scopus57 WoS47 Europe PMC30
2018 Parikh, A., Kathawala, K., Song, Y., Zhou, X. F., & Garg, S. (2018). Curcumin-loaded self-nanomicellizing solid dispersion system: part I: development, optimization, characterization, and oral bioavailability. Drug Delivery and Translational Research, 8(5), 1389-1405.
DOI Scopus39 WoS31 Europe PMC22
2018 Parikh, A., Kathawala, K., Li, J., Chen, C., Shan, Z., Cao, X., . . . Garg, S. (2018). Curcumin-loaded self-nanomicellizing solid dispersion system: part II: in vivo safety and efficacy assessment against behavior deficit in Alzheimer disease. Drug delivery and translational research, 8(5), 1406-1420.
DOI Scopus39 WoS34 Europe PMC31
2018 Parikh, A., Kathawala, K., Li, J., Chen, C., Shan, Z., Cao, X., . . . Zhou, X. F. (2018). Self-nanomicellizing solid dispersion of edaravone: part II: in vivo assessment of efficacy against behavior deficits and safety in Alzheimer’s disease model. Drug Design, Development and Therapy, 12, 2111-2128.
DOI Scopus24 WoS22 Europe PMC16
2018 Parikh, A., Kathawala, K., Tan, C. C., Garg, S., & Zhou, X. F. (2018). Self-nanomicellizing solid dispersion of edaravone: part I – oral bioavailability improvement. Drug Design, Development and Therapy, 12, 2051-2069.
DOI Scopus30 WoS26 Europe PMC20
2017 Parikh, A., Kathawala, K., Tan, C. C., Garg, S., & Zhou, X. F. (2017). Lipid-based nanosystem of edaravone: development, optimization, characterization and in vitro/in vivo evaluation. Drug delivery, 24(1), 962-978.
DOI Scopus32 WoS30 Europe PMC24
2016 Parikh, A., Kathawala, K., Tan, C. C., Garg, S., & Zhou, X. F. (2016). Development of a novel oral delivery system of edaravone for enhancing bioavailability. International Journal of Pharmaceutics, 515(1-2), 490-500.
DOI Scopus41 WoS38 Europe PMC28
2015 Jiao, S. S., Yao, X. Q., Liu, Y. H., Wang, Q. H., Zeng, F., Lu, J. J., . . . Wang, Y. J. (2015). Edaravone alleviates Alzheimer's disease-type pathologies and cognitive deficits. Proceedings of the National Academy of Sciences of the United States of America, 112(16), 5225-5230.
DOI Scopus152 WoS145 Europe PMC118
2014 Anand, U., Parikh, A., Ugwu, M. C., & Agu, R. U. (2014). Drug transporters in the nasal epithelium: an overview of strategies in targeted drug delivery. Future medicinal chemistry, 6(12), 1381-1397.
DOI
2014 Anand, U., Parikh, A., Ugwu, M. C., & Agu, R. U. (2014). Drug transporters in the nasal epithelium: An overview of strategies in targeted drug delivery. Future Medicinal Chemistry, 6(12), 1381-1389.
DOI Scopus25 Europe PMC18
2014 Parikh, A., Anand, U., Ugwu, M. C., Feridooni, T., Massoud, E., & Agu, R. U. (2014). Drug-eluting nasal implants: Formulation, characterization, clinical applications and challenges. Pharmaceutics, 6(2), 249-267.
DOI Scopus45
2013 Kathawala, K. J., Parikh, A. Y., Inamdar, B. P., & Shah, S. G. (2013). Mouth dissolving tablet: superlative conclusive dosage in solid form for modern age. Pharma science monitor, 4(4), 416-437.
2013 Inamdar, B. P., Kathawala, K. J., Parikh, A. Y., Shah, T. R., & Shah, J. N. (2013). Formulation development and characterization of chitosan nanoparticles of montelukast sodium for site specific drug delivery in management of asthma. International journal of drug formulation and research, 4(4), 87-101.
2013 Gupta, A. L., Kathawala, K. J., Parikh, A. Y., Agrawal, Y. K., Shah, J. N., & Gandhi, T. M. (2013). Nanopolymeric formulation development and characterization of anti asthmatic drug for pulmonary drug delivery. Pharma science monitor, 4(4), 388-402.
2013 Shao, D., Massoud, E., Anand, U., Parikh, A., Cowley, E., Clarke, D., & Agu, R. U. (2013). Organic cation transporters in human nasal primary culture: Expression and functional activity. Therapeutic delivery, 4(4), 439-451.
DOI Scopus10 Europe PMC5
2012 Panchal, R., Patel, H., Patel, V., Joshi, P., & Parikh, A. (2012). Formulation and evalution of montelukast sodium: chitosan based spray dried microspheres for pulmonary drug delivery. Journal of pharmacy and bioallied sciences, 4(1), S110-S111.
DOI Scopus13
2011 Upadhyay, S., Parikh, A., Joshi, P., Upadhyay, U. M., & Chotai, N. P. (2011). Intranasal drug delivery system- a glimpse to become maestro. Journal of applied pharmaceutical science, 1(3), 34-44.
Scopus59
2010 Patel, K. M., Patel, C. N., Panigrahi, B., Parikh, A. S., & Patel, H. N. (2010). Development and validation of spectrophotometric methods for the estimation of mesalamine in tablet dosage forms. Journal of young pharmacists, 2(3), 284-288.
DOI

Year Citation
2017 Zhou, X., Parikh, A., & Garg, S. (2017). WO2017157350, Edaravone dosage form.

Courses I teach

  • PHAR 3025 Dosage Form Design 4 (2025)

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