Andreas Evdokiou

Professor Andreas Evdokiou

Michell - McGrath Breast Cancer Fellow

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Professor Evdokiou’s work is looking at how cancer cells harness the body’s natural process of bone regeneration.

Professor Evdokiou and his team at the University of Adelaide are aiming to understand why bone provides such fertile ‘soil’ for tumour cells to develop.

Their work is vital because once breast cancer has spread away from the primary site in the breast to other parts of the body (most commonly to the bone), it is essentially incurable and the major cause of mortality from the disease. Bone metastasis causes bone destruction, which can lead to increased risk of fracture, chronic pain and even paralysis. New and more effective treatments to prevent breast metastasis are urgently required.

He is particularly exploring the role of two types of bone cell that drive the turnover of bone: osteoclasts, large cells that remove old bone leaving a cavity; and osteoblasts, which lay down new bone to fill the cavity.

“If cancer cells move into the bone, they secrete a variety of factors that talk to the normal cells in our body, telling them to degrade more bone,” Professor Evdokiou explains.

“Bone degradation allows for the release of factors from the bone itself that attract other cells into the tumour area and these cells change to become osteoclasts, which degrade bone. So there is this vicious cycle of cancer cells talking to osteoclasts, leading to more bone degradation, more factors being released, more tumour cells growing. The osteoblasts, which lay down new bone, can’t keep up with the amount of bone loss.”

  • Position: Michell - McGrath Breast Cancer Fellow
  • Phone: 82227451
  • Email:
  • Fax: 8222 7872
  • Campus: The Queen Elizabeth Hospital
  • Building: QEH - Basil Hetzel Institute, floor 1
  • Org Unit: Surgical Specialties

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