Andreas Evdokiou

Professor Andreas Evdokiou

Michell - McGrath Breast Cancer Fellow

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


Professor Evdokiou’s work is looking at how cancer cells harness the body’s natural process of bone regeneration.

Professor Evdokiou and his team at the University of Adelaide are aiming to understand why bone provides such fertile ‘soil’ for tumour cells to develop.

Their work is vital because once breast cancer has spread away from the primary site in the breast to other parts of the body (most commonly to the bone), it is essentially incurable and the major cause of mortality from the disease. Bone metastasis causes bone destruction, which can lead to increased risk of fracture, chronic pain and even paralysis. New and more effective treatments to prevent breast metastasis are urgently required.

He is particularly exploring the role of two types of bone cell that drive the turnover of bone: osteoclasts, large cells that remove old bone leaving a cavity; and osteoblasts, which lay down new bone to fill the cavity.

“If cancer cells move into the bone, they secrete a variety of factors that talk to the normal cells in our body, telling them to degrade more bone,” Professor Evdokiou explains.

“Bone degradation allows for the release of factors from the bone itself that attract other cells into the tumour area and these cells change to become osteoclasts, which degrade bone. So there is this vicious cycle of cancer cells talking to osteoclasts, leading to more bone degradation, more factors being released, more tumour cells growing. The osteoblasts, which lay down new bone, can’t keep up with the amount of bone loss.”

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  • Current Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2016 Principal Supervisor Hepatic Cellular Immune Functions in Colorectal Cancer Liver Metastasis Doctor of Philosophy Doctorate Full Time Ms Namfon Pantarat
    2016 Co-Supervisor The role of Gg in modulation of macrophage function and breast cancer susceptibility Doctor of Philosophy Doctorate Full Time Mr Joseph Wrin
    2015 Principal Supervisor Fibrosis, Cancer and the Pre-Metastatic Niche: Implications for Peroxidases Doctor of Philosophy Doctorate Full Time Mr Christopher Difelice
    2015 Co-Supervisor Immune Modulation of Breast Density and Cancer Risk Doctor of Philosophy Doctorate Full Time Maddison Rose McKinnon Archer
  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2015 - 2019 Principal Supervisor A New Role for Peroxidases in Bone Repair Doctor of Philosophy Doctorate Full Time Miss Alexandra Jayne Shoubridge
    2014 - 2017 Principal Supervisor Targeting Cancer in the Bone with the Hypoxia Activated Pro-drug Evofosfamide Doctor of Philosophy Doctorate Full Time Mr Vasilios Liapis
    2013 - 2017 Principal Supervisor Adoptive Transfer of Ex Vivo Expanded Gamma Delta T Cells Targeting Osteolytic Cancer in the Bone Doctor of Philosophy Doctorate Full Time Aneta Zysk
    2013 - 2016 Principal Supervisor A New Role for Inflammatory Peroxidases in Breast Cancer Development and Metastasis Doctor of Philosophy Doctorate Full Time Dr Bill Panagopoulos
    2013 - 2015 Co-Supervisor Synthesis of Anodic Alumina Nanotubes for Drug Delivery and Nanotoxicity Study: understanding of bio-nano interactions by a nanomaterial model Doctor of Philosophy Doctorate Full Time Mr Ye Wang
    2010 - 2013 Co-Supervisor Treatment of Ewing Sarcoma Family of Tumours through the Pharmacological Activation of p53 Doctor of Philosophy Doctorate Full Time Miss Kathleen Irene Pishas
    2009 - 2012 Principal Supervisor Efficacy of Pro-Apoptotic Receptor Agonists in the Treatment of Primary Breast Cancer and Bone Metastasis Doctor of Philosophy Doctorate Full Time Dr Irene Zinonos
    2007 - 2012 Principal Supervisor The Effectsof the Histone Deacetylase Inhibitor LBH589 on Breast Cancer in Bone and on Physiological Bone Remodelling Doctor of Philosophy Doctorate Full Time Ms Michelle Lee
    2003 - 2007 Principal Supervisor Apo 2L/TRAIL in Breast Cancer Bone Metastasis: in vitro and in vivo Studies into Molecular Mechanisms of Action and Resistance Doctor of Philosophy Doctorate Full Time Mr Le Thai
    2001 - 2005 Principal Supervisor Novel Combination Treatment with Trail for Osteosarcoma Therapy: The Use of Inhibitors of the Mevalonate Pathway Doctor of Philosophy Doctorate Full Time Dr Agatha Labrinidis
    2000 - 2003 Co-Supervisor Molecular Mechanisms of Apo2L/TRAIL Induced Apoptosis In Normal and Malignant Cells Doctor of Philosophy Doctorate Full Time Mr Stelios Bouralexis
  • Position: Michell - McGrath Breast Cancer Fellow
  • Phone: 82227451
  • Email: andreas.evdokiou@adelaide.edu.au
  • Fax: 8222 7872
  • Campus: The Queen Elizabeth Hospital
  • Building: QEH - Basil Hetzel Institute, floor 1
  • Org Unit: Surgical Specialties

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