Andrea Harrington
School of Biomedicine
Faculty of Health and Medical Sciences
Dr. Harrington is a laboratory based scientist undertaking research aimed at understanding how the nervous system controls the function of the gastrointestinal (GI) tract and its role in GI dysfunction. Dr. Harrington is using multiple approaches in molecular biology, neuroanatomy tract tracing and integrative physiology to understand the central pathways signalling visceral pain.
Characterising spinal cord circuits signalling colorectal pain
Mapping shared spinal pathways from visceral organs
Identifying ascending tracts relaying visceral pain from the spinal cord into the brain and how these change with chronic visceral hypersensitivity
Identifying the role of descending pain modulation in chronic visceral pain
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Journals
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Book Chapters
Year Citation 2023 Harrington, A. M. (2023). Translating Colonic Sensory Afferent Peripheral Mechanosensitivity into the Spinal Cord Dorsal Horn. In S. M. Brierley, & N. J. Spencer (Eds.), Visceral Pain (pp. 161-181). Springer.
DOI Scopus12023 Harrington, A. M. (2023). Mechanisms of Spinal Cord Plasticity in Rodent Models of Acute and Post-Colitis Visceral Hypersensitivity. In S. Brierley, & N. J. Spencer (Eds.), Visceral Pain (pp. 183-196). Springer International Publishing.
DOI2018 Harrington, A. M., Castro, J., Erickson, A., Grundy, L., & Brierley, S. M. (2018). Extrinsic Sensory Afferent Nerves Innervating the Gastrointestinal Tract in Health and Disease. In H. M. Said (Ed.), Physiology of the Gastrointestinal Tract: Sixth Edition (Vol. 1-2, pp. 387-418). United Kingdom: Academic Press.
DOI Scopus212012 Hughes, P., Brierley, S., Castro Kraftchenko, J., Harrington, A., & Blackshaw, L. (2012). Experimental colitis models. In A. Szallasi, & T. Biro (Eds.), Methods in Pharmacology and Toxicology: TRP Channels in Drug Discovery, Volume II (Vol. 2, 1 ed., pp. 379-390). USA: Springer.
DOI Scopus12012 Brierley, S., Hughes, P., Harrington, A., & Blackshaw, L. (2012). Innervation of the gastrointestinal tract by spinal and vagal afferent nerves. In L. Johnson, F. Ghishan, J. Kaunitz, J. Merchant, H. Said, & J. Wood (Eds.), Physiology of the Gastrointestinal Tract, Volume 1, Fifth Edition (Vol. 1, 5 ed., pp. 703-729). United Kingdom: Elsevier.
DOI Scopus162012 Brierley, S. M., Hughes, P., Harrington, A., & Blackshaw, L. A. (2012). Innervation of the Gastrointestinal Tract by Spinal and Vagal Afferent Nerves. In Physiology of the Gastrointestinal Tract, Two Volume Set (pp. 703-731).
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Conference Papers
Year Citation 2020 Harrington, A., Garcia-Caraballo, S., Grundy, L., Castro, J., Hannig, G., & Brierley, S. (2020). CHRONIC INTRA-COLONIC LINACLOTIDE ADMINISTRATION ALTERS GLIAL ACTIVATION IN A MOUSE MODEL OF CHRONIC VISCERAL HYPERSENSITIVITY. In GASTROENTEROLOGY Vol. 158 (pp. S803). Austin, TX: W B SAUNDERS CO-ELSEVIER INC.
WoS12019 Castro, J., Harrington, A., Maddern, J., Schober, G., Grundy, L. A., Ge, P., . . . Brierley, S. (2019). CHRONIC INTRACOLONIC ADMINISTRATION OF LINACLOTIDE INHIBITS NOCICEPTIVE SIGNALING IN A MOUSE MODEL OF CHRONIC VISCERAL HYPERSENSITIVITY. In GASTROENTEROLOGY Vol. 156 (pp. S570). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
WoS22019 Grundy, L., Castro, J., Maddern, J., Harrington, A., Hannig, G., Ge, P., & Brierley, S. (2019). CHRONIC COLONIC ADMINISTRATION OF THE GUANYLATE CYCLASE-C AGONIST LINACLOTIDE ATTENUATES COLITIS INDUCED BLADDER AFFERENT HYPERACTIVITY. In GASTROENTEROLOGY Vol. 156 (pp. S363). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
WoS12018 Grundy, L., Castro, J., Harrington, A., Garcia-Caraballo, S., Maddern, J., Rychkov, G., & Brierley, S. (2018). Colitis-induced chronic colonic hypersensitivity induces cross organ sensitisation of bladder afferent pathways. In NEUROGASTROENTEROLOGY AND MOTILITY Vol. 30 (pp. 1 page). WILEY.
WoS12017 Grundy, L. A., Castro, J., Harrington, A., Peters, S., Feil, R., Miller, P., . . . Brierley, S. (2017). EXTRACELLULAR CGMP REDUCES THE EXCITABILITY OF SENSORY DORSAL ROOT GANGLION NEURONS VIA AN EXTRACELLULAR MECHANISM. In GASTROENTEROLOGY Vol. 152 (pp. S156). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
DOI WoS12015 Castro, J., Harrington, A. M., Lieu, T., Garcia-Caraballo, S., Maddern, J., O'Donnell, T., . . . Brierley, S. M. (2015). A Visceral Representation of Itch: Identification 'Itch-Specific' Pruritogenic Mechanisms Within Colonic Sensory Pathways. In GASTROENTEROLOGY Vol. 148 (pp. S733). Washington, DC: W B SAUNDERS CO-ELSEVIER INC. 2015 Harrington, A. M., Castro, J., Garcia-Caraballo, S., Maddern, J., O'Donnell, T., Grundy, L., . . . Brierley, S. M. (2015). GC-C Agonists As Regulators of Visceral Sensation: Modulation of Mucosal Sensitivity via the Epithelial GC-C/cGMP Pathway. In GASTROENTEROLOGY Vol. 148 (pp. S732-S733). Washington, DC: W B SAUNDERS CO-ELSEVIER INC. 2015 Castro, J., Harrington, A. M., Garcia-Caraballo, S., Maddern, J., O'Donnell, T., Grundy, L., . . . Brierley, S. M. (2015). Chronic Activation of the GC-C/cGMP Pathway by Linaclotide Inhibits Ascending Nociceptive Pathways and Restores Aberrant Spinal Cord Signaling. In GASTROENTEROLOGY Vol. 148 (pp. S194). Washington, DC: W B SAUNDERS CO-ELSEVIER INC. 2014 Castro, J., Rychkov, G. Y., Ghetti, A., Harrington, A. M., Kurtz, C. B., Silos-Santiago, I., & Brierley, S. M. (2014). Extracellular Cyclic GMP (cGMP), the Downstream Mediator Released in Response to Linaclotide-Induced Activation of Guanylate Cyclase-C (GC-C), Reduces Excitability of Murine and Human Dorsal Root Ganglion (DRG) Neurons. In GASTROENTEROLOGY Vol. 146 (pp. S722). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC. 2014 Harrington, A. M., Castro, J., Garcia-Caraballo, S., Maddern, J., Craik, D., Adams, D. J., & Brierley, S. M. (2014). α-Conotoxin Vc1.1 Targets GABAB Receptors Modulating CaV2.2 and CaV2.3 Calcium Channels in Sensory Pathways Mediating Chronic Visceral Pain. In GASTROENTEROLOGY Vol. 146 (pp. S156). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC. 2013 Castro, J., Harrington, A. M., Mann, E. A., Cohen, M. B., Kurtz, C. B., Silos-Santiago, A., & Brierley, S. M. (2013). Mechanisms Underlying Linaclotide Induced Inhibition of Colonic Nociception. In GASTROENTEROLOGY Vol. 144 (pp. S134). Orlando, FL: W B SAUNDERS CO-ELSEVIER INC. 2013 Harrington, A. M., Castro, J., Young, R. L., Kurtz, C. B., Silos-Santiago, A., Nguyen, N. Q., . . . Brierley, S. M. (2013). Alterations in the Guanylate Cyclase-C/cGMP Pathway in Patients With Irritable Bowel Syndrome With Constipation. In GASTROENTEROLOGY Vol. 144 (pp. S59-S60). Orlando, FL: W B SAUNDERS CO-ELSEVIER INC. 2013 McGuire, C., Harrington, A. M., Hubball, A., McPhail, H., Peiris, M., Bulmer, D. C., . . . Blackshaw, L. A. (2013). Anatomical Sensory Nerve Markers in Human Gut. In GASTROENTEROLOGY Vol. 144 (pp. S56). Orlando, FL: W B SAUNDERS CO-ELSEVIER INC.
WoS12013 Hughes, P. A., Harrington, A. M., Castro, J., Isaacs, N. J., Moretta, M., Hicks, G. A., . . . Brierley, S. M. (2013). Increased Efficacy of the Peripherally-Restricted Selective Kappa-Opioid Receptor Agonist, Asimadoline, in Chronic Visceral Hypersensitivity. In GASTROENTEROLOGY Vol. 144 (pp. S934-S935). Orlando, FL: W B SAUNDERS CO-ELSEVIER INC. 2012 Castro, J., Harrington, A. M., Hughes, P. A., Martin, C., Silos-Santiago, A., Kurtz, C. B., . . . Brierley, S. M. (2012). Mechanism of Action for Linaclotide Induced Abdominal Pain Relief. In GASTROENTEROLOGY Vol. 142 (pp. S699). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
WoS52012 Harrington, A. M., Brierley, S. M., Castro, J., Isaacs, N. J., & Blackshaw, L. A. (2012). Characterization of Dorsal Horn Neurons Activated by Noxious Colorectal Distension in Health and Chronic Visceral Hypersensitivity. In GASTROENTEROLOGY Vol. 142 (pp. S699). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC. 2012 Castro, J., Harrington, A. M., Page, A. J., & Brierley, S. M. (2012). Downstream Signaling Pathways of Nitric Oxide Induced Modulation of Colonic Afferent Mechanosensitivity. In GASTROENTEROLOGY Vol. 142 (pp. S697). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC. 2011 Castro, J., Harrington, A., Hughes, P. A., Martin, C., Page, A. J., Blackshaw, L. A., & Brierley, S. M. (2011). Nitric Oxide Mechanism of Action on Visceral Nociceptors. In GASTROENTEROLOGY Vol. 140 (pp. S536). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC. 2011 Harrington, A., Brierley, S. M., Castro, J., Hughes, P. A., & Blackshaw, L. A. (2011). Identification of Colonic Afferent Central Terminals and Changes Following Colonic Inflammation. In GASTROENTEROLOGY Vol. 140 (pp. S131). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC. 2010 Harrington, A., Young, R., Brierley, S., & Blackshaw, L. (2010). TRPV1 mediates acid activation of esophageal sensory pathways. In Proceedings of 2010 Joint International Neurogastroenterology and Motility Meeting, NGM 2010 Vol. 22 (pp. 55). UK: Wiley-Blackwell Publishing Ltd. 2010 Hughes, P., Brierley, S., Harrington, A., Castro, J., Martin, C., & Blackshaw, L. (2010). Differential coupling of cytokine receptors to sensory neurons in health and post inflammation. In Proceedings Vol. 138 (pp. 136-137). W B SAUNDERS CO-ELSEVIER INC.
DOI2010 Harrington, A. (2010). Immunohistochemical localisation shows that muscarinic receptors M1R, M2R and M3R mediate both cholinergic and nitrergic pathways in human colon. In Digestive Disease Week 2010 Vol. 138 (pp. S-572). United States: Gastroenterology, Elsevier.
DOI2010 Harrington, A., Peck, C., Farmer, P., Hutson, J., & Southwell, B. (2010). The high-affinity choline transporter (CHT1) colocalises with VAChT in human intestine and provides an additional label for cholinergic nerves. In Digestive Disease Week 2010 Vol. 138 (pp. S-572). United States: Gastroenterology.
DOI2009 Harrington, A., Hughes, P., Martin, C., Isaacs, N., Brierley, S., & Blackshaw, L. (2009). Localisation and function of transient receptor potential ion channel melastatin subtype 8 (TRPM8) in mouse colonic primary afferent nerve fibers. In Autonomic neuroscience Vol. 149 (pp. 29). United States: Elsevier B.V..
DOI2009 Brierley, S., Harrington, A., Hughes, P., Page, A., Corey, D., Kwan, K., . . . Blackshaw, L. (2009). TRPA1 contributes to specific mechanotransduction currents in isolated DRG neurons. In TRP Channels: From Sensory Signaling to Human Disease (pp. 76). Stockholm, Sweden. 2008 Harrington, A., Farmer, P., Peck, C., Hutson, J., & Southwell, B. (2008). Acetylcholine muscarinic receptor localisation on interstitial cells of Cajal in the human small intestine. In Neurogastroenterology and Motility Vol. 20 (pp. 58). United Kingdom: Wiley-Blackwell Publishing Ltd..
DOI2008 Harrington, A. (2008). Choline Transporter: A New Label for Cholinergic Nerves in the Human Enteric Nervous System That Reveals Cholinergic Nerves in Colonic Mucosa. In Gastroenterology Vol. 134 (pp. A-394). United States: Elsevier Inc.
DOI2007 Harrington, A. M., Hutson, J. M., & Southwell, B. R. (2007). Localisation of pre-synaptic cholinergic muscarinic receptor sulaytpe 2 (M2r) in the guinea pig enteric nervous system. In GASTROENTEROLOGY Vol. 132 (pp. A224). Washington, DC: W B SAUNDERS CO-ELSEVIER INC. 2006 Harrington, A. (2006). Localisation of muscarinic receptor M1-M3 immunoreactivity in human colon. In Neurogastroenterology and Motility Vol. 18 (pp. 777). United Kingdom: Wiley-Blackwell Publishing Ltd..
DOI2006 Harrington, A., Lee, M., Ong, S., Yong, E., Farmer, P., Hutson, J., & Southwell, B. (2006). Choline transporter: an additional marker of cholinergic nerves in the enteric nervous system. In Gastroenterology Vol. 130 (pp. A-381). United States: Elsevier B.V.
DOI2005 Harrington, A., & Southwell, B. (2005). Choline transporter: A new marker of cholinergic nerves in rat enteric nervous system. In Journal of Gastroenterology and Hepatology Vol. 20 (pp. A-93). Australia: Wiley-Blackwell Publishing Asia.
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Conference Items
Mapping sites of visceral convergence connecting the colon and bladder. ARC Discovery 2022 DP220101269 (Harrington, Brierley, Grundy)
Silencing visceral pain pathways using novel optogenetic techniques in vivo NHMRC 2019 Project (Spencer, Brierley, Zagorodnyuk, Harrington)
Central pathways of visceral pain. ARC Discovery 2018 (Harrington, Brierly, Mazzone, Rychkov)
Characterisation of visceral afferent spinal cord pathways ARC DECRA 2013-2017
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