Andrea Harrington

Andrea Harrington

School of Medicine

College of Health

Dr. Harrington is a laboratory based scientist undertaking research aimed at understanding how the nervous system controls the function of the gastrointestinal (GI) tract and its role in GI dysfunction. Dr. Harrington is using multiple approaches in molecular biology, neuroanatomy tract tracing and integrative physiology to understand the central pathways signalling visceral pain.

Characterising spinal cord circuits signalling colorectal pain

Mapping shared spinal pathways from visceral organs

Identifying ascending tracts relaying visceral pain from the spinal cord into the brain and how these change with chronic visceral hypersensitivity

Identifying the role of descending pain modulation in chronic visceral pain

 

Year Citation
2025 Touhara, K. K., Rossen, N. D., Deng, F., Castro, J., Harrington, A. M., Chu, T., . . . Julius, D. (2025). Topological segregation of stress sensors along the gut crypt-villus axis. Nature, 640(8059), 732-742.
DOI Scopus13 WoS10 Europe PMC12
2025 Rossen, N. D., Touhara, K. K., Castro, J., Harrington, A. M., Caraballo, S. G., Deng, F., . . . Julius, D. (2025). Population imaging of enterochromaffin cell activity reveals regulation by somatostatin. Proceedings of the National Academy of Sciences of the United States of America, 122(19), e2501525122-1-e2501525122-10.
DOI Scopus1 WoS1 Europe PMC2
2025 Wang, Q., McGovern, A. E., Kyloh, M., Rychkov, G., Spencer, N. J., Mazzone, S. B., . . . Harrington, A. M. (2025). Splanchnic and Pelvic Spinal Afferent Pathways Relay Sensory Information From the Mouse Colorectum Into Distinct Brainstem Circuits. Journal of Neurochemistry, 169(9), e70211.
DOI Scopus1 WoS1 Europe PMC2
2024 Touhara, K. K., Rossen, N. D., Deng, F., Chu, T., Harrington, A. M., Garcia Caraballo, S., . . . Julius, D. (2024). Crypt and Villus Enterochromaffin Cells are Distinct Stress Sensors in the Gut.. bioRxiv.
DOI
2024 Castro, J., Maddern, J., Erickson, A., Harrington, A. M., & Brierley, S. M. (2024). Peripheral and central neuroplasticity in a mouse model of endometriosis. Journal of Neurochemistry, 168(11), 3777-3800.
DOI Scopus12 WoS10 Europe PMC7
2023 Wang, Q. Q., Caraballo, S. G., Rychkov, G., McGovern, A. E., Mazzone, S. B., Brierley, S. M., & Harrington, A. M. (2023). Comparative localization of colorectal sensory afferent central projections in the mouse spinal cord dorsal horn and caudal medulla dorsal vagal complex. Journal of Comparative Neurology, 532(2), e25546-1-e25546-32.
DOI Scopus7 WoS6 Europe PMC5
2023 Grundy, L., Tay, C., Christie, S., Harrington, A. M., Castro, J., Cardoso, F. C., . . . Brierley, S. M. (2023). The T-type calcium channel Ca V 3.2 regulates bladder afferent responses to mechanical stimuli. Pain, 164(5), 1012-1026.
DOI Scopus5 WoS4 Europe PMC4
2022 Kyloh, M. A., Hibberd, T. J., Castro, J., Harrington, A. M., Travis, L., Dodds, K. N., . . . Spencer, N. J. (2022). Disengaging spinal afferent nerve communication with the brain in live mice. Communications Biology, 5(1), 915-1-915-15.
DOI Scopus13 WoS12 Europe PMC12
2022 Maddern, J., Grundy, L., Harrington, A., Schober, G., Castro, J., & Brierley, S. M. (2022). A syngeneic inoculation mouse model of endometriosis that develops multiple comorbid visceral and cutaneous pain like behaviours. Pain, 163(8), 1622-1635.
DOI Scopus10 WoS9 Europe PMC7
2022 Castro, J., Harrington, A. M., Chegini, F., Matusica, D., Spencer, N. J., Brierley, S. M., . . . Barry, C. M. (2022). Clodronate Treatment Prevents Vaginal Hypersensitivity in a Mouse Model of Vestibulodynia.. Frontiers in Cellular and Infection Microbiology, 11, 784972-1-784972-11.
DOI Scopus9 WoS10 Europe PMC9
2022 Caldwell, A., Grundy, L., Harrington, A. M., Garcia-Caraballo, S., Castro, J., Bunnett, N. W., & Brierley, S. M. (2022). TGR5 agonists induce peripheral and central hypersensitivity to bladder distension. Scientific Reports, 12(1), 9920-1-9920-19.
DOI Scopus5 WoS3 Europe PMC2
2022 Castro, J., Garcia-Caraballo, S., Maddern, J., Schober, G., Lumsden, A., Harrington, A., . . . Brierley, S. M. (2022). Olorinab (APD371), a peripherally acting, highly selective, full agonist of the cannabinoid receptor 2, reduces colitis-induced acute and chronic visceral hypersensitivity in rodents. Pain, 163(1), e72-e86.
DOI Scopus24 WoS23 Europe PMC20
2021 Brierley, S. M., Grundy, L., Castro, J., Harrington, A. M., Hannig, G., & Camilleri, M. (2021). Guanylate cyclase-C agonists as peripherally acting treatments of chronic visceral pain. Trends in Pharmacological Sciences, 43(2), 110-122.
DOI Scopus21 WoS20 Europe PMC17
2021 Brizuela, M., Castro, J., Harrington, A. M., & Brierley, S. M. (2021). Pruritogenic mechanisms and gut sensation: putting the "irritant" into irritable bowel syndrome. American Journal of Physiology: Gastrointestinal and Liver Physiology, 320(6), G1131-G1141.
DOI Scopus9 WoS8 Europe PMC6
2021 Castro, J., Maddern, J., Erickson, A., Caldwell, A., Grundy, L., Harrington, A. M., & Brierley, S. M. (2021). Pharmacological modulation of voltage-gated sodium (Na(V)) channels alters nociception arising from the female reproductive tract. Pain, 162(1), 227-242.
DOI Scopus11 WoS12 Europe PMC9
2021 Grundy, L., Caldwell, A., Garcia-Caraballo, S., Grundy, D., Spencer, N. J., Dong, X., . . . Brierley, S. M. (2021). Activation of MrgprA3 and MrgprC11 on bladder-innervating afferents induces peripheral and central hypersensitivity to bladder distension. The Journal of Neuroscience, 14(17), 3900-3916.
DOI Scopus14 WoS12 Europe PMC11
2021 Castro, J., Maddern, J., Grundy, L., Manavis, J., Harrington, A. M., Schober, G., & Brierley, S. M. (2021). A mouse model of endometriosis that displays vaginal, colon, cutaneous, and bladder sensory comorbidities. The FASEB Journal, 35(4), 1-20.
DOI Scopus17 WoS16 Europe PMC14
2020 Tsukimi, Y., Pustovit, R. V., Harrington, A. M., Garcia-Caraballo, S., Brierley, S. M., Di Natale, M., . . . Furness, J. B. (2020). Effects and sites of action of a M1 receptor positive allosteric modulator on colonic motility in rats and dogs compared with 5-HT4 agonism and cholinesterase inhibition. Neurogastroenterology and Motility, 32(8), e13866-1-e13866-10.
DOI Scopus6 WoS6 Europe PMC5
2020 Grundy, L., Caldwell, A., Garcia Caraballo, S., Erickson, A., Schober, G., Castro Kraftchenko, J., . . . Brierley, S. M. (2020). Histamine induces peripheral and central hypersensitivity to bladder distension via the histamine H₁ receptor and TRPV1. American journal of physiology. Renal physiology, 318(2), F298-F314.
DOI Scopus58 WoS58 Europe PMC45
2020 Harrington, A., Garcia-Caraballo, S., Grundy, L., Castro, J., Hannig, G., & Brierley, S. (2020). Mo1146 CHRONIC INTRA-COLONIC LINACLOTIDE ADMINISTRATION ALTERS GLIAL ACTIVATION IN A MOUSE MODEL OF CHRONIC VISCERAL HYPERSENSITIVITY. Gastroenterology, 158(6), S-803.
DOI
2019 Ge, P., Ren, J., Harrington, A. M., Grundy, L., Castro, J., Brierley, S. M., & Hannig, G. (2019). Linaclotide treatment reduces endometriosis-associated vaginal hyperalgesia and mechanical allodynia through viscerovisceral cross-talk.. Pain, 160(11), 2566-2579.
DOI Scopus32 WoS27 Europe PMC28
2019 Castro, J., Harrington, A. M., Lieu, T., Garcia Caraballo, S., Maddern, J., Schober, G., . . . Brierley, S. M. (2019). Activation of pruritogenic TGR5, MRGPRA3, and MRGPRC11 on colon-innervating afferents induces visceral hypersensitivity. JCI insight, 4(20), e131712-1-e131712-24.
DOI Scopus60 WoS61 Europe PMC54
2019 Grundy, L., Harrington, A. M., Caldwell, A., Castro, J., Staikopoulos, V., Zagorodnyuk, V. P., . . . Brierley, S. M. (2019). Translating peripheral bladder afferent mechanosensitivity to neuronal activation within the lumbosacral spinal cord of mice. Pain, 160(4), 793-804.
DOI Scopus30 WoS29 Europe PMC26
2019 Harrington, A. M., Caraballo, S. G., Maddern, J. E., Grundy, L., Castro, J., & Brierley, S. M. (2019). Colonic afferent input and dorsal horn neuron activation differs between the thoracolumbar and lumbosacral spinal cord. American journal of physiology. Gastrointestinal and liver physiology, 317(3), G285-G303.
DOI Scopus34 WoS30 Europe PMC27
2018 Grundy, L., Erickson, A., Caldwell, A., Garcia-Caraballo, S., Rychkov, G., Harrington, A., & Brierley, S. (2018). Tetrodotoxin-sensitive voltage-gated sodium channels regulate bladder afferent responses to distension. Pain, 159(12), 2573-2584.
DOI Scopus26 WoS29 Europe PMC23
2018 Grundy, L., Harrington, A. M., Castro, J., Garcia-Caraballo, S., Deiteren, A., Maddern, J., . . . Brierley, S. M. (2018). Chronic linaclotide treatment reduces colitis-induced neuroplasticity and reverses persistent bladder dysfunction. JCI Insight, 3(19), e121841-1-e121841-20.
DOI Scopus61 WoS58 Europe PMC54
2018 Spencer, N., Greenheigh, S., Kyloh, M., Hibberd, T., Sharma, H., Grundy, L., . . . Zagorodnyuk, V. (2018). Identifying unique subtypes of spinal afferent nerve endings within the urinary bladder of mice. Journal of Comparative Neurology, 526(4), 707-720.
DOI Scopus40 WoS37 Europe PMC30
2018 Castro, J., Grundy, L., Deiteren, A., Harrington, A., O'Donnell, T., Maddern, J., . . . Brierley, S. (2018). Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain. British Journal of Pharmacology, 175(12), 2384-2398.
DOI Scopus39 WoS33 Europe PMC30
2018 Erickson, A., Deiteren, A., Harrington, A., Garcia-Caraballo, S., Castro, J., Caldwell, A., . . . Brierley, S. (2018). Voltage-gated sodium channels: (NaV)igating the field to determine their contribution to visceral nociception. The Journal of Physiology, 596(5), 785-807.
DOI Scopus34 WoS35 Europe PMC30
2018 Sadeghi, M., Erickson, A., Castro, J., Deiteren, A., Harrington, A., Grundy, L., . . . Brierley, S. (2018). Contribution of membrane receptor signalling to chronic visceral pain. International Journal of Biochemistry and Cell Biology, 98, 10-23.
DOI Scopus31 WoS26 Europe PMC25
2017 Campaniello, M. A., Mavrangelos, C., Eade, S., Harrington, A. M., Blackshaw, L. A., Brierley, S. M., . . . Hughes, P. A. (2017). Acute colitis chronically alters immune infiltration mechanisms and sensory neuro-immune interactions.. Brain, Behavior, and Immunity, 60, 319-332.
DOI Scopus18 WoS16 Europe PMC14
2017 Inserra, M., Israel, M., Caldwell, A., Castro, J., Deuis, J., Harrington, A., . . . Vetter, I. (2017). Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1. Scientific Reports, 7(1), 42810-1-42810-19.
DOI Scopus62 WoS61 Europe PMC54
2017 Castro, J., Harrington, A., Garcia-Caraballo, S., Maddern, J., Grundy, L., Zhang, J., . . . Brierley, S. (2017). α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABAB receptors. Gut, 66(6), 1083-1094.
DOI Scopus80 WoS75 Europe PMC68
2016 Campaniello, M., Harrington, A., Martin, C., Ashley Blackshaw, L., Brierley, S., & Hughes, P. (2016). Activation of colo-rectal high-threshold afferent nerves by Interleukin-2 is tetrodotoxin-sensitive and upregulated in a mouse model of chronic visceral hypersensitivity. Neurogastroenterology and Motility, 28(1), 54-63.
DOI Scopus14 WoS13 Europe PMC12
2015 Castro, J., Harrington, A. M., Lieu, T., Garcia-Caraballo, S., Maddern, J., O'Donnell, T., . . . Brierley, S. M. (2015). Mo1876 A Visceral Representation of Itch: Identification ‘Itch-Specific’ Pruritogenic Mechanisms Within Colonic Sensory Pathways. Gastroenterology, 148(4), S-733.
DOI
2014 de Araujo, A., Mobli, M., Castro, J., Harrington, A., Vetter, I., Dekan, Z., . . . Alewood, P. (2014). Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain. Nature Coomunications, 5(1), 3165-1-3165-12.
DOI Scopus115 WoS114 Europe PMC82
2013 Blackshaw, L., Brierley, S., Harrington, A., & Hughes, P. (2013). TRP channels in visceral pain. The Open Pain Journal, 6(SPEC.ISSUE.1), 23-30.
DOI Scopus2
2013 Kentish, S., O'Donnell, T., Isaacs, N., Young, R., Li, H., Harrington, A., . . . Page, A. (2013). Gastric vagal afferent modulation by leptin is influenced by food intake status. Journal of Physiology-London, 591(7), 1921-1934.
DOI Scopus76 WoS71 Europe PMC61
2013 Hughes, P., Castro Kraftchenko, J., Harrington, A., Isaacs, N., Moretta, M., Hicks, G., . . . Brierley, S. (2013). Increased κ-opioid receptor expression and function during chronic visceral hypersensitivity. Gut, Online(7), 1-2.
DOI Scopus37 WoS34 Europe PMC32
2013 Castro, J., Harrington, A., Hughes, P., Martin, C., Ge, P., Shea, C., . . . Brierley, S. (2013). Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-c and extracellular cyclic guanosine 3′,5′-monophosphate. Gastroenterology, 145(6), 1334-1346.
DOI Scopus250 WoS225 Europe PMC220
2013 Harrington, A., Brierley, S., Isaacs, N., Young, R., & Blackshaw, L. (2013). Identifying spinal sensory pathways activated by noxious esophageal acid. Neurogastroenterology and Motility, 25(10), 660-668.
DOI Scopus20 WoS16 Europe PMC15
2013 Hughes, P., Harrington, A., Castro Kraftchenko, J., Liebregts, T., Adam, B., Grasby, D., . . . Brierley, S. (2013). Sensory neuro-immune interactions differ between Irritable Bowel Syndrome subtypes. Gut, 62(10), 1456-1465.
DOI Scopus182 WoS165 Europe PMC149
2012 Harrington, A., Brierley, S., Isaacs, N., Hughes, P., Castro Kraftchenko, J., & Blackshaw, L. (2012). Sprouting of colonic afferent central terminals and increased spinal mitogen-activated protein kinase expression in a mouse model of chronic visceral hypersensitivity. Journal of Comparative Neurology, 520(10), 2241-2255.
DOI Scopus61 WoS56 Europe PMC52
2012 Brierley, S., Castro, J., Harrington, A., Hughes, P., Martin, C., Silos-Santiago, A., . . . Blackshaw, A. (2012). Guanylate cyclase C receptor agonists, linaclotide and uroguanylin, modulate intestinal nociception. NEUROGASTROENTEROLOGY AND MOTILITY, 24, 26.
2011 Harrington, A., Hughes, P., Martin, C., Yang, J., Castro, J., Isaacs, N., . . . Brierley, S. (2011). A novel role for TRPM8 in visceral afferent function. PAIN®, 152(7), 1459-1468.
DOI Scopus135 WoS122 Europe PMC117
2011 Blackshaw, L., Brierley, S., Hughes, P., & Harrington, A. (2011). The Hot Mustard Receptor's Role in Gut Motor Function. Gastroenterology, 141(2), 423-427.
DOI Scopus9 WoS10 Europe PMC9
2011 Brierley, S., Castro Kraftchenko, J., Harrington, A., Hughes, P., Page, A., Rychkov, G., & Blackshaw, L. (2011). TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity. Journal of Physiology-London, 589(14), 3575-3593.
DOI Scopus120 WoS109 Europe PMC109
2010 Brierley, S., Hughes, P., Harrington, A., Rychkov, G., & Blackshaw, L. (2010). Identifying the ion channels responsible for signaling gastro-intestinal based pain. Pharmaceuticals, 3(9), 2768-2798.
DOI Scopus14 WoS11 Europe PMC10
2010 Harrington, A., Peck, C., Liu, L., Burcher, E., Hutson, J., & Southwell, B. (2010). Localization of muscarinic receptors M1R, M2R and M3R in the human colon. Neurogastroenterology and Motility, 22(9), 999-1008.
DOI Scopus47 WoS41 Europe PMC39
2010 Harrington, A. (2010). Immunoreactivity for the high-affinity choline transporter colocalises with VAChT in the human enteric nervous system. Cell and Tissue Research, 341(1), 33-48.
DOI Scopus15 WoS12 Europe PMC11
2010 Harrington, A., Hutson, J., & Southwell, B. (2010). Cholinergic neurotransmission and muscarinic receptors in the enteric nervous system. Progress in Histochemistry and Cytochemistry, 44(4), 173-202.
DOI Scopus77 WoS68 Europe PMC62
2009 Peck, C., Samsuria, S., Harrington, A., King, S., Hutson, J., & Southwell, B. (2009). Fall in density, but not number of myenteric neurons and circular muscle nerve fibres in guinea-pig colon with ageing. Neurogastroenterology and Motility, 21(10), 1075-1090.
DOI Scopus34 WoS26 Europe PMC30
2009 Brierley, S., Hughes, P., Page, A., Kwan, K., Martin, C., O'Donnell, T., . . . Blackshaw, L. (2009). The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli. Gastroenterology, 137(6), 2084-2095.
DOI Scopus242 WoS217 Europe PMC199
2008 Harrington, A., Hutson, J., & Southwell, B. (2008). Immunohistochemical localisation of pre-synaptic muscarinic receptor subtype-2 (M2r) in the enteric nervous system of guinea-pig ileum. Cell and Tissue Research, 332(1), 37-48.
DOI Scopus9 WoS7 Europe PMC5
2007 Harrington, A., Hutson, J., & Southwell, B. (2007). High affinity choline transporter immunoreactivity in rat ileum myenteric nerves. Cell and Tissue Research, 327(3), 421-431.
DOI Scopus6 WoS7 Europe PMC5
2007 Harrington, A., Hutson, J., & Southwell, B. (2007). Immunohistochemical localisation of cholinergic muscarinic receptor subtype 1 (M1r) in the guinea pig and human enteric nervous system. Journal of Chemical Neuroanatomy, 33(4), 193-201.
DOI Scopus21 WoS19 Europe PMC16
2005 Harrington, A., Hutson, J., & Southwell, B. (2005). Immunohistochemical localisation of substance P NK1 receptor in guinea pig distal colon. Neurogastroenterology and Motility, 17(5), 727-737.
DOI Scopus27 WoS23 Europe PMC23
2001 Harrington, A. M. (2001). The first women religious in Japan: Mother Saint Mathilde Raclot and the French connection.. Catholic Historical Review, 87(4), 603-623.
DOI Scopus8 WoS2

Year Citation
2023 Harrington, A. M. (2023). Translating Colonic Sensory Afferent Peripheral Mechanosensitivity into the Spinal Cord Dorsal Horn. In S. M. Brierley, & N. J. Spencer (Eds.), Visceral Pain (pp. 161-181). Springer.
DOI Scopus2
2023 Harrington, A. M. (2023). Mechanisms of Spinal Cord Plasticity in Rodent Models of Acute and Post-Colitis Visceral Hypersensitivity. In S. Brierley, & N. J. Spencer (Eds.), Visceral Pain (pp. 183-196). Springer International Publishing.
DOI
2018 Harrington, A. M., Castro, J., Erickson, A., Grundy, L., & Brierley, S. M. (2018). Extrinsic Sensory Afferent Nerves Innervating the Gastrointestinal Tract in Health and Disease. In H. M. Said (Ed.), Physiology of the Gastrointestinal Tract: Sixth Edition (Vol. 1-2, pp. 387-418). United Kingdom: Academic Press.
DOI Scopus21
2012 Hughes, P., Brierley, S., Castro Kraftchenko, J., Harrington, A., & Blackshaw, L. (2012). Experimental colitis models. In A. Szallasi, & T. Biro (Eds.), Methods in Pharmacology and Toxicology: TRP Channels in Drug Discovery, Volume II (Vol. 2, 1 ed., pp. 379-390). USA: Springer.
DOI Scopus1
2012 Brierley, S., Hughes, P., Harrington, A., & Blackshaw, L. (2012). Innervation of the gastrointestinal tract by spinal and vagal afferent nerves. In L. Johnson, F. Ghishan, J. Kaunitz, J. Merchant, H. Said, & J. Wood (Eds.), Physiology of the Gastrointestinal Tract, Volume 1, Fifth Edition (Vol. 1, 5 ed., pp. 703-729). United Kingdom: Elsevier.
DOI Scopus17
2012 Brierley, S. M., Hughes, P., Harrington, A., & Blackshaw, L. A. (2012). Innervation of the Gastrointestinal Tract by Spinal and Vagal Afferent Nerves. In Physiology of the Gastrointestinal Tract Two Volume Set (pp. 703-731).
DOI Scopus3

Year Citation
2020 Harrington, A., Garcia-Caraballo, S., Grundy, L., Castro, J., Hannig, G., & Brierley, S. (2020). CHRONIC INTRA-COLONIC LINACLOTIDE ADMINISTRATION ALTERS GLIAL ACTIVATION IN A MOUSE MODEL OF CHRONIC VISCERAL HYPERSENSITIVITY. In GASTROENTEROLOGY Vol. 158 (pp. S803). Austin, TX: W B SAUNDERS CO-ELSEVIER INC.
WoS1
2019 Castro, J., Harrington, A., Maddern, J., Schober, G., Grundy, L. A., Ge, P., . . . Brierley, S. (2019). CHRONIC INTRACOLONIC ADMINISTRATION OF LINACLOTIDE INHIBITS NOCICEPTIVE SIGNALING IN A MOUSE MODEL OF CHRONIC VISCERAL HYPERSENSITIVITY. In GASTROENTEROLOGY Vol. 156 (pp. S570). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
WoS2
2019 Grundy, L., Castro, J., Maddern, J., Harrington, A., Hannig, G., Ge, P., & Brierley, S. (2019). CHRONIC COLONIC ADMINISTRATION OF THE GUANYLATE CYCLASE-C AGONIST LINACLOTIDE ATTENUATES COLITIS INDUCED BLADDER AFFERENT HYPERACTIVITY. In GASTROENTEROLOGY Vol. 156 (pp. S363). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
WoS1
2018 Grundy, L., Castro, J., Harrington, A., Garcia-Caraballo, S., Maddern, J., Rychkov, G., & Brierley, S. (2018). Colitis-induced chronic colonic hypersensitivity induces cross organ sensitisation of bladder afferent pathways. In NEUROGASTROENTEROLOGY AND MOTILITY Vol. 30 (pp. 1 page). WILEY.
WoS1
2017 Grundy, L. A., Castro, J., Harrington, A., Peters, S., Feil, R., Miller, P., . . . Brierley, S. (2017). EXTRACELLULAR CGMP REDUCES THE EXCITABILITY OF SENSORY DORSAL ROOT GANGLION NEURONS VIA AN EXTRACELLULAR MECHANISM. In GASTROENTEROLOGY Vol. 152 (pp. S156). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
DOI WoS1
2015 Castro, J., Harrington, A. M., Lieu, T., Garcia-Caraballo, S., Maddern, J., O'Donnell, T., . . . Brierley, S. M. (2015). A Visceral Representation of Itch: Identification 'Itch-Specific' Pruritogenic Mechanisms Within Colonic Sensory Pathways. In GASTROENTEROLOGY Vol. 148 (pp. S733). Washington, DC: W B SAUNDERS CO-ELSEVIER INC.
2015 Harrington, A. M., Castro, J., Garcia-Caraballo, S., Maddern, J., O'Donnell, T., Grundy, L., . . . Brierley, S. M. (2015). GC-C Agonists As Regulators of Visceral Sensation: Modulation of Mucosal Sensitivity via the Epithelial GC-C/cGMP Pathway. In GASTROENTEROLOGY Vol. 148 (pp. S732-S733). Washington, DC: W B SAUNDERS CO-ELSEVIER INC.
2015 Castro, J., Harrington, A. M., Garcia-Caraballo, S., Maddern, J., O'Donnell, T., Grundy, L., . . . Brierley, S. M. (2015). Chronic Activation of the GC-C/cGMP Pathway by Linaclotide Inhibits Ascending Nociceptive Pathways and Restores Aberrant Spinal Cord Signaling. In GASTROENTEROLOGY Vol. 148 (pp. S194). Washington, DC: W B SAUNDERS CO-ELSEVIER INC.
2014 Castro, J., Rychkov, G. Y., Ghetti, A., Harrington, A. M., Kurtz, C. B., Silos-Santiago, I., & Brierley, S. M. (2014). Extracellular Cyclic GMP (cGMP), the Downstream Mediator Released in Response to Linaclotide-Induced Activation of Guanylate Cyclase-C (GC-C), Reduces Excitability of Murine and Human Dorsal Root Ganglion (DRG) Neurons. In GASTROENTEROLOGY Vol. 146 (pp. S722). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
2014 Harrington, A. M., Castro, J., Garcia-Caraballo, S., Maddern, J., Craik, D., Adams, D. J., & Brierley, S. M. (2014). α-Conotoxin Vc1.1 Targets GABAB Receptors Modulating CaV2.2 and CaV2.3 Calcium Channels in Sensory Pathways Mediating Chronic Visceral Pain. In GASTROENTEROLOGY Vol. 146 (pp. S156). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
2013 Castro, J., Harrington, A. M., Mann, E. A., Cohen, M. B., Kurtz, C. B., Silos-Santiago, A., & Brierley, S. M. (2013). Mechanisms Underlying Linaclotide Induced Inhibition of Colonic Nociception. In GASTROENTEROLOGY Vol. 144 (pp. S134). Orlando, FL: W B SAUNDERS CO-ELSEVIER INC.
2013 Harrington, A. M., Castro, J., Young, R. L., Kurtz, C. B., Silos-Santiago, A., Nguyen, N. Q., . . . Brierley, S. M. (2013). Alterations in the Guanylate Cyclase-C/cGMP Pathway in Patients With Irritable Bowel Syndrome With Constipation. In GASTROENTEROLOGY Vol. 144 (pp. S59-S60). Orlando, FL: W B SAUNDERS CO-ELSEVIER INC.
2013 McGuire, C., Harrington, A. M., Hubball, A., McPhail, H., Peiris, M., Bulmer, D. C., . . . Blackshaw, L. A. (2013). Anatomical Sensory Nerve Markers in Human Gut. In GASTROENTEROLOGY Vol. 144 (pp. S56). Orlando, FL: W B SAUNDERS CO-ELSEVIER INC.
WoS1
2013 Hughes, P. A., Harrington, A. M., Castro, J., Isaacs, N. J., Moretta, M., Hicks, G. A., . . . Brierley, S. M. (2013). Increased Efficacy of the Peripherally-Restricted Selective Kappa-Opioid Receptor Agonist, Asimadoline, in Chronic Visceral Hypersensitivity. In GASTROENTEROLOGY Vol. 144 (pp. S934-S935). Orlando, FL: W B SAUNDERS CO-ELSEVIER INC.
2012 Castro, J., Harrington, A. M., Hughes, P. A., Martin, C., Silos-Santiago, A., Kurtz, C. B., . . . Brierley, S. M. (2012). Mechanism of Action for Linaclotide Induced Abdominal Pain Relief. In GASTROENTEROLOGY Vol. 142 (pp. S699). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
WoS5
2012 Harrington, A. M., Brierley, S. M., Castro, J., Isaacs, N. J., & Blackshaw, L. A. (2012). Characterization of Dorsal Horn Neurons Activated by Noxious Colorectal Distension in Health and Chronic Visceral Hypersensitivity. In GASTROENTEROLOGY Vol. 142 (pp. S699). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
2012 Castro, J., Harrington, A. M., Page, A. J., & Brierley, S. M. (2012). Downstream Signaling Pathways of Nitric Oxide Induced Modulation of Colonic Afferent Mechanosensitivity. In GASTROENTEROLOGY Vol. 142 (pp. S697). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
2011 Castro, J., Harrington, A., Hughes, P. A., Martin, C., Page, A. J., Blackshaw, L. A., & Brierley, S. M. (2011). Nitric Oxide Mechanism of Action on Visceral Nociceptors. In GASTROENTEROLOGY Vol. 140 (pp. S536). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
2011 Harrington, A., Brierley, S. M., Castro, J., Hughes, P. A., & Blackshaw, L. A. (2011). Identification of Colonic Afferent Central Terminals and Changes Following Colonic Inflammation. In GASTROENTEROLOGY Vol. 140 (pp. S131). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
2010 Harrington, A., Young, R., Brierley, S., & Blackshaw, L. (2010). TRPV1 mediates acid activation of esophageal sensory pathways. In Proceedings of 2010 Joint International Neurogastroenterology and Motility Meeting, NGM 2010 Vol. 22 (pp. 55). UK: Wiley-Blackwell Publishing Ltd.
2010 Hughes, P., Brierley, S., Harrington, A., Castro, J., Martin, C., & Blackshaw, L. (2010). Differential coupling of cytokine receptors to sensory neurons in health and post inflammation. In Proceedings Vol. 138 (pp. 136-137). W B SAUNDERS CO-ELSEVIER INC.
DOI
2010 Harrington, A. (2010). Immunohistochemical localisation shows that muscarinic receptors M1R, M2R and M3R mediate both cholinergic and nitrergic pathways in human colon. In Digestive Disease Week 2010 Vol. 138 (pp. S-572). United States: Gastroenterology, Elsevier.
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2010 Harrington, A., Peck, C., Farmer, P., Hutson, J., & Southwell, B. (2010). The high-affinity choline transporter (CHT1) colocalises with VAChT in human intestine and provides an additional label for cholinergic nerves. In Digestive Disease Week 2010 Vol. 138 (pp. S-572). United States: Gastroenterology.
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2009 Harrington, A., Hughes, P., Martin, C., Isaacs, N., Brierley, S., & Blackshaw, L. (2009). Localisation and function of transient receptor potential ion channel melastatin subtype 8 (TRPM8) in mouse colonic primary afferent nerve fibers. In Autonomic neuroscience Vol. 149 (pp. 29). United States: Elsevier B.V..
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2009 Brierley, S., Harrington, A., Hughes, P., Page, A., Corey, D., Kwan, K., . . . Blackshaw, L. (2009). TRPA1 contributes to specific mechanotransduction currents in isolated DRG neurons. In TRP Channels: From Sensory Signaling to Human Disease (pp. 76). Stockholm, Sweden.
2008 Harrington, A., Farmer, P., Peck, C., Hutson, J., & Southwell, B. (2008). Acetylcholine muscarinic receptor localisation on interstitial cells of Cajal in the human small intestine. In Neurogastroenterology and Motility Vol. 20 (pp. 58). United Kingdom: Wiley-Blackwell Publishing Ltd..
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2008 Harrington, A. (2008). Choline Transporter: A New Label for Cholinergic Nerves in the Human Enteric Nervous System That Reveals Cholinergic Nerves in Colonic Mucosa. In Gastroenterology Vol. 134 (pp. A-394). United States: Elsevier Inc.
DOI
2007 Harrington, A. M., Hutson, J. M., & Southwell, B. R. (2007). Localisation of pre-synaptic cholinergic muscarinic receptor sulaytpe 2 (M2r) in the guinea pig enteric nervous system. In GASTROENTEROLOGY Vol. 132 (pp. A224). Washington, DC: W B SAUNDERS CO-ELSEVIER INC.
2006 Harrington, A. (2006). Localisation of muscarinic receptor M1-M3 immunoreactivity in human colon. In Neurogastroenterology and Motility Vol. 18 (pp. 777). United Kingdom: Wiley-Blackwell Publishing Ltd..
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2006 Harrington, A., Lee, M., Ong, S., Yong, E., Farmer, P., Hutson, J., & Southwell, B. (2006). Choline transporter: an additional marker of cholinergic nerves in the enteric nervous system. In Gastroenterology Vol. 130 (pp. A-381). United States: Elsevier B.V.
DOI
2005 Harrington, A., & Southwell, B. (2005). Choline transporter: A new marker of cholinergic nerves in rat enteric nervous system. In Journal of Gastroenterology and Hepatology Vol. 20 (pp. A-93). Australia: Wiley-Blackwell Publishing Asia.
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Year Citation
2022 Harrington, A., Schober, G., Maddern, J., Wang, Q., Hannig, G., & Brierley, S. (2022). Descending pain modulation of colorectal nociceptive processing in the spinal cord is imbalanced in a mouse model of post-colitis chronic visceral hypersensitivity and is reduced by chronic oral linaclotide treatment. Poster session presented at the meeting of Abstracts of Digestive Disease Week (DDW 2022), as published in Gastroenterology. San Diego, CA: Elsevier.
DOI
2022 Harrington, A., Wang, Q., Hannig, G., & Brierley, S. (2022). Colorectal nociceptive processing in the caudal ventrolateral medulla and the lateral parabrachial nuclei is increased in a mouse model of chronic visceral hypersensitivity and is reversed by chronic linaclotide treatment. Poster session presented at the meeting of Abstracts of Digestive Disease Week (DDW 2022), as published in Gastroenterology. San Diego, CA: Elsevier.
DOI
2017 Castro, J., Deiteren, A., Harrington, A., Maddern, J., Moore, J., Garcia-Caraballo, S., . . . Brierley, S. (2017). Chronic oral administration of linaclotide inhibits nociceptive signalling in response to noxious colorectal distension in a model of chronic visceral hypersensitivity. Poster session presented at the meeting of Abstracts of the Digestive Disease Week (DDW) 2017, as published in Gastroenterology. Chicago, IL: Elsevier.
DOI WoS1
2016 Garcia-Caraballo, S., Harrington, A. M., Castro, J., Hannig, G., Kurtz, C., Silos-Santiago, A., . . . Brierley, S. M. (2016). Guanylate cyclase-C expression is down-regulated in colonic biopsies from female irritable bowel syndrome patients with constipation. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY-BLACKWELL.
2016 Garcia-Carraballo, S., Harrington, A., Castro, J., Hannig, G., Kurtz, C. B., Silos-Santiago, A., . . . Brierley, S. (2016). Guanylate Cyclase-C Expression Is Down-Regulated in Colonic Biopsies From Female Irritable Bowel Syndrome Patients With Constipation. Poster session presented at the meeting of GASTROENTEROLOGY. San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
DOI WoS2
2014 Harrington, A. M., Castro, J., Young, R. L., Kurtz, C., Silos-Santiago, A., Nguyen, N., . . . Brierley, S. M. (2014). Distinct alterations in the guanylate cyclase-C/cGMP pathway are evident across different subtypes of irritable bowel syndrome patients. Poster session presented at the meeting of Neurogastroenterology and Motility. Guangzhou, China: John Wiley and Sons.
DOI
2014 Castro, J., Rychkov, G. Y., Ghetti, A., Harrington, A. M., Kurtz, C., Silos-Santiago, A., & Brierley, S. M. (2014). Extracellular cGMP, the downstream effector released in response to linaclotide-induced activation of guanylate cyclase-C, reduces excitability of murine and human dorsal root ganglion neurons. Poster session presented at the meeting of Neurogastroenterology and Motility. Guangzhou, China: John Wiley and Sons.
DOI WoS1
2014 Harrington, A. M., Castro, J., Young, R. L., Kurtz, C. B., Silos-Santiago, I., Nguyen, N. Q., . . . Brierley, S. M. (2014). Distinct Alterations in the Guanylate Cyclase-C (GC-C)/Cyclic GMP (cGMP) Pathway Are Evident Across Different Subtypes of Irritable Bowel Syndrome (IBS) Patients. Poster session presented at the meeting of GASTROENTEROLOGY. Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
WoS3
2013 Harrington, A. M., Castro, J., Young, R. L., Kurtz, C., Silos-Santiago, A., Nguyen, N., . . . Brierley, S. M. (2013). The guanylatecyclase-c/CGMP pathway is altered in patients with irritable bowel syndrome with constipation. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY-BLACKWELL.
DOI
2013 Hannig, G., Castro, J., Harrington, A., Ge, P., Jin, H., Kessler, M. M., . . . Silos-Santiago, I. (2013). Activation of the guanylate cyclase-C/cGMP pathway decreases gastrointestinal pain. Poster session presented at the meeting of Journal of Gastroenterology and Hepatology. Shanghai, China: Wiley.
DOI
2013 Harrington, A. M., Castro, J., & Brierley, S. M. (2013). Peripheral modulation of TRPA1 alters dorsal horn neuron activation to colorectal distension. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY.
2013 Castro, J., Harrington, A. M., & Brierley, S. M. (2013). TRPV3 contributes to chronic visceral mechanical hypersensitivity. Poster session presented at the meeting of Abstracts of the 17th American Neurogastroenterology and Motility Society Annual Scientific Meeting, as published in Neurogastroenterology & Motility. Huntington Beach, California: Wiley-Blackwell.
DOI
2013 Castro, J., Harrington, A. M., Mann, E., Cohen, M. B., Kurtz, C., Silos-Santiago, A., & Brierley, S. M. (2013). Mechanisms of linaclotide-induced inhibition of colonic nociception. Poster session presented at the meeting of Abstracts of the 17th American Neurogastroenterology and Motility Society Annual Scientific Meeting, as published in Neurogastroenterology & Motility. Huntington Beach, CA: Wiley-Blackwell.
DOI
2013 Brierley, S. M., Castro, J., Harrington, A., Hughes, P., Martin, C., Silos-Santiago, A., . . . Blackshaw, A. (2013). MECHANISM OF ACTION FOR LINACLOTIDE-INDUCED ABDOMINAL PAIN RELIEF. Poster session presented at the meeting of GUT. Glasgow, SCOTLAND: BMJ PUBLISHING GROUP.
DOI
2012 Hughes, P., Nicholson, I., Bird, D., To, S., Isaacs, N., Grasby, D., . . . Krumbiegel, D. (2012). C-IBS patients lack monocyte derived β-endorphin which results in disinhibition of colonic afferent mechanosensitivity. Poster session presented at the meeting of Gastroenterology. USA: WB Saunders.
DOI
2011 Hughes, P., Harrington, A., Brierley, S., Maldeniya, M., Martin, C., Persson, J., . . . Blackshaw, L. (2011). Cytokine modulation of visceral afferents via cation channels is switched in chronic visceral hypersensitivity. Poster session presented at the meeting of Gastroenterology. Chicago, IL: W B Saunders Co.
DOI
2010 Brierley, S., Castro Kraftchenko, J., Martin, C., Harrington, A., Hughes, P., & Blackshaw, L. (2010). Differential regulation of TRP channel function in acute and chronic mechanical hypersensitivity. Poster session presented at the meeting of Abstract of theJoint International Neurogastroenterology and Motility Meeting, as published in Neurogastroenterology and Motility. Boston, MA, USA: Wiley-Blackwell Publishing.
DOI

 Mapping sites of visceral convergence connecting the colon and bladder. ARC Discovery 2022 DP220101269 (Harrington, Brierley, Grundy)

Silencing visceral pain pathways using novel optogenetic techniques in vivo NHMRC 2019 Project (Spencer, Brierley, Zagorodnyuk, Harrington)

Central pathways of visceral pain. ARC Discovery 2018 (Harrington, Brierly, Mazzone, Rychkov)

Characterisation of visceral afferent spinal cord pathways ARC DECRA 2013-2017

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