Amy Reichelt

Amy Reichelt

Adelaide Medical School

Faculty of Health and Medical Sciences


My primary research goal is to define the cognitive and functional impacts of obesity and nutrition on the brain. This research program has immediate relevance to a growing public health issue in Australia, where nearly a third of all children, and two-thirds of all adults, are overweight or obese. I use a multidimensional approach involving cutting-edge behavioural and neuropharmacology paradigms – including transgenic mice (Cre-lox, KI and KO models), in vivo fiber-photometry, chemogenetics, and optogenetics to study cognition and the functional effects of simulated ‘junk food’ diets in rodents; combined with molecular and chemical profiling of the post mortem rodent brain. This framework spans from individual gene expression, neurochemical alterations of neurons and their surrounding extracellular components (perineuronal nets), to long-lasting effects on neurodevelopment to provide a comprehensive picture of the neurobiological impact of obesity from the micro- to macro-scale.

I have built a strong reputation as an emerging thought leader in neuroscience and nutrition fields, demonstrated through numerous grants, awards and speaking invitations.

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  • Journals

    Year Citation
    2020 Bodden, C., Hannan, A., & Reichelt, A. (2020). Diet-Induced Modification of the Sperm Epigenome Programs Metabolism and Behavior. Trends in Endocrinology and Metabolism, 31(2), 131-149.
    DOI Scopus4 WoS4 Europe PMC2
    2020 Reichelt, A. (2020). Is loss of perineuronal nets a critical pathological event in Alzheimer's disease?. EBioMedicine, 59, 102946.
    DOI
    2020 Lowe, C., Morton, J., & Reichelt, A. (2020). Adolescent obesity and dietary decision making—a brain-health perspective. The Lancet Child and Adolescent Health, 4(5), 388-396.
    DOI Scopus1
    2020 Loughman, A., Quinn, T., Nation, M., Reichelt, A., Moore, R., Van, T., . . . Tang, M. (2020). Infant microbiota in colic: Predictive associations with problem crying and subsequent child behavior. Journal of Developmental Origins of Health and Disease, 1-11.
    DOI Scopus1 Europe PMC1
    2020 Reichelt, A., Loughman, A., Bernard, A., Raipuria, M., Abbott, K., Dachtler, J., . . . Moore, R. (2020). An intermittent hypercaloric diet alters gut microbiota, prefrontal cortical gene expression and social behaviours in rats. Nutritional Neuroscience, 23(8), 613-627.
    DOI Scopus6 WoS7 Europe PMC1
    2019 Reichelt, A., Collett, J., Landmann, O., & Hallam, K. (2019). Assessing the impacts of daily Cannabis versus alcohol and methamphetamines on young Australians in youth AOD treatment. BMC Psychiatry, 19(1), 11 pages.
    DOI
    2019 Pham, X., Wright, D., Atapour, N., Chan, J., Watkins, K., Worthy, K., . . . Reser, D. (2019). Internal Subdivisions of the Marmoset Claustrum Complex: Identification by Myeloarchitectural Features and High Field Strength Imaging. Frontiers in Neuroanatomy, 13, 13 pages.
    DOI
    2019 Reichelt, A., Gibson, G., Abbott, K., & Hare, D. (2019). A high-fat high-sugar diet in adolescent rats impairs social memory and alters chemical markers characteristic of atypical neuroplasticity and parvalbumin interneuron depletion in the medial prefrontal cortex. Food and Function, 10(4), 1985-1998.
    DOI Scopus6 WoS4
    2019 Lowe, C., Reichelt, A., & Hall, P. (2019). The Prefrontal Cortex and Obesity: A Health Neuroscience Perspective. Trends in Cognitive Sciences, 23(4), 349-361.
    DOI Scopus24 WoS17 Europe PMC4
    2019 Pervolaraki, E., Tyson, A., Pibiri, F., Poulter, S., Reichelt, A., Rodgers, R., . . . Dachtler, J. (2019). The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in Nrxn2 deletion mice. Molecular Autism, 10(1), 13 pages.
    DOI Scopus4 WoS4 Europe PMC2
    2019 Reichelt, A., Hare, D., Bussey, T., & Saksida, L. (2019). Perineuronal Nets: Plasticity, Protection, and Therapeutic Potential. Trends in Neurosciences, 42(7), 458-470.
    DOI Scopus11 WoS6 Europe PMC2
    2019 Lowe, C., & Reichelt, A. (2019). Can magnetic resonance imaging reveal the neural signatures of dietary self-control?. Journal of Neuroscience, 39(4), 581-583.
    DOI
    2018 Reichelt, A., Stoeckel, L., Reagan, L., Winstanley, C., & Page, K. (2018). Dietary influences on cognition. Physiology and Behavior, 192, 118-126.
    DOI Scopus9 WoS8 Europe PMC3
    2018 Xu, T., & Reichelt, A. (2018). Sucrose or sucrose and caffeine differentially impact memory and anxiety-like behaviours, and alter hippocampal parvalbumin and doublecortin. Neuropharmacology, 137, 24-32.
    DOI Scopus8 WoS9 Europe PMC2
    2018 Buyukata, C., Vukalo, M., Xu, T., Khore, M., & Reichelt, A. (2018). Impact of high sucrose diets on the discrimination of spatial and object memories with overlapping features. Physiology and Behavior, 192, 127-133.
    DOI Scopus2 WoS1
    2017 Reichelt, A., & Rank, M. (2017). The impact of junk foods on the adolescent brain. Birth Defects Research, 109(20), 1649-1658.
    DOI Scopus13 WoS12 Europe PMC5
    2017 Reichelt, A., Westbrook, R., & Morris, M. (2017). Editorial: Impact of diet on learning, memory and cognition. Frontiers in Behavioral Neuroscience, 11, 2 pages.
    DOI Scopus3 WoS3 Europe PMC3
    2017 Wong, A., Dogra, V., & Reichelt, A. (2017). High-sucrose diets in male rats disrupt aspects of decision making tasks, motivation and spatial memory, but not impulsivity measured by operant delay-discounting. Behavioural Brain Research, 327, 144-154.
    DOI Scopus4 WoS4
    2017 Baker, K., Loughman, A., Spencer, S., & Reichelt, A. (2017). The impact of obesity and hypercaloric diet consumption on anxiety and emotional behavior across the lifespan. Neuroscience and Biobehavioral Reviews, 83, 173-182.
    DOI Scopus14 WoS14 Europe PMC6
    2017 Labouesse, M., Lassalle, O., Richetto, J., Iafrati, J., Weber-Stadlbauer, U., Notter, T., . . . Meyer, U. (2017). Hypervulnerability of the adolescent prefrontal cortex to nutritional stress via reelin deficiency. Molecular Psychiatry, 22(7), 961-971.
    DOI Scopus28 WoS26 Europe PMC12
    2016 Reichelt, A. (2016). Adolescent maturational transitions in the prefrontal cortex and dopamine signaling as a risk factor for the development of obesity and high fat/high sugar diet induced cognitive deficits. Frontiers in Behavioral Neuroscience, 10(OCT), 17 pages.
    DOI Scopus30 WoS29 Europe PMC12
    2016 Baker, K., & Reichelt, A. (2016). Impaired fear extinction retention and increased anxiety-like behaviours induced by limited daily access to a high-fat/high-sugar diet in male rats: Implications for diet-induced prefrontal cortex dysregulation. Neurobiology of Learning and Memory, 136(Dec), 127-138.
    DOI Scopus25 WoS27 Europe PMC14
    2016 Abbott, K., Morris, M., Westbrook, R., & Reichelt, A. (2016). Sex-specific effects of daily exposure to sucrose on spatial memory performance in male and female rats, and implications for estrous cycle stage. Physiology and Behavior, 162, 52-60.
    DOI Scopus20 WoS20 Europe PMC12
    2016 Reichelt, A., Morris, M., & Westbrook, R. (2016). Daily access to sucrose impairs aspects of spatial memory tasks reliant on pattern separation and neural proliferation in rats. Learning and Memory, 23(7), 386-390.
    DOI Scopus13 WoS13 Europe PMC7
    2016 Reichelt, A., Abbott, K., Westbrook, R., & Morris, M. (2016). Differential motivational profiles following adolescent sucrose access in male and female rats. Physiology and Behavior, 157, 13-19.
    DOI Scopus33 WoS28 Europe PMC12
    2016 Boitard, C., Parkes, S., Cavaroc, A., Tantot, F., Castanon, N., Layé, S., . . . Ferreira, G. (2016). Switching adolescent high-fat diet to adult control diet restores neurocognitive alterations. Frontiers in Behavioral Neuroscience, 10(NOV), 11 pages.
    DOI Scopus23 WoS22 Europe PMC10
    2015 Morris, M., Beilharz, J., Maniam, J., Reichelt, A., & Westbrook, R. (2015). Why is obesity such a problem in the 21st century? The intersection of palatable food, cues and reward pathways, stress, and cognition. Neuroscience and Biobehavioral Reviews, 58, 36-45.
    DOI Scopus103 WoS103 Europe PMC56
    2015 Reichelt, A., Maniam, J., Westbrook, R., & Morris, M. (2015). Dietary-induced obesity disrupts trace fear conditioning and decreases hippocampal reelin expression. Brain, Behavior, and Immunity, 43, 68-75.
    DOI Scopus32 WoS31 Europe PMC18
    2015 Exton-McGuinness, M., Lee, J., & Reichelt, A. (2015). Updating memories-The role of prediction errors in memory reconsolidation. Behavioural Brain Research, 278, 375-384.
    DOI Scopus71 WoS67 Europe PMC38
    2015 Reichelt, A., Killcross, S., Hambly, L., Morris, M., & Westbrook, R. (2015). Impact of adolescent sucrose access on cognitive control, recognition memory, and parvalbumin immunoreactivity. Learning and Memory, 22(4), 215-224.
    DOI Scopus47 WoS46 Europe PMC27
    2015 Reichelt, A., Westbrook, R., & Morris, M. (2015). Integration of reward signalling and appetite regulating peptide systems in the control of food-cue responses. British Journal of Pharmacology, 172(22), 5225-5238.
    DOI Scopus19 WoS15 Europe PMC12
    2014 Siette, J., Reichelt, A., & Westbrook, R. (2014). A bout of voluntary running enhances context conditioned fear, its extinction, and its reconsolidation. Learning and Memory, 21(2), 73-81.
    DOI Scopus29 WoS29 Europe PMC19
    2014 Reichelt, A. C., Morris, M. J., & Westbrook, R. (2014). Cafeteria diet impairs expression of sensory-specific satiety and stimulus-outcome learning. FRONTIERS IN PSYCHOLOGY, 5, 11 pages.
    DOI WoS22 Europe PMC15
    2013 Reichelt, A., & Lee, J. (2013). Memory reconsolidation in aversive and appetitive settings. Frontiers in Behavioral Neuroscience, 7(SEP), 18 pages.
    DOI Scopus50 WoS45
    2013 Martire, S., Tran, D., & Reichelt, A. (2013). Preventing binge eating with deep brain stimulation - Can compulsive eating be switched off?. Frontiers in Psychiatry, 4(DEC), 168.
    DOI
    2013 Reichelt, A., Good, M., & Killcross, S. (2013). Attenuation of acute d-amphetamine-induced disruption of conflict resolution by clozapine, but not α-flupenthixol in rats. Journal of Psychopharmacology, 27(11), 1023-1031.
    DOI Scopus2 WoS2 Europe PMC2
    2013 Humby, T., Eddy, J., Good, M., Reichelt, A., & Wilkinson, L. (2013). A novel translational assay of response inhibition and impulsivity: Effects of prefrontal cortex lesions, drugs used in ADHD, and serotonin 2C receptor antagonism. Neuropsychopharmacology, 38(11), 2150-2159.
    DOI Scopus27 WoS25 Europe PMC21
    2013 Reichelt, A., Killcross, S., Wilkinson, L., Humby, T., & Good, M. (2013). Transgenic expression of the FTDP-17 tau<inf>V337M</inf> mutation in brain dissociates components of executive function in mice. Neurobiology of Learning and Memory, 104, 73-81.
    DOI Scopus6 WoS7 Europe PMC6
    2013 Reichelt, A., & Lee, J. (2013). Over-expectation generated in a complex appetitive goal-tracking task is capable of inducing memory reconsolidation. Psychopharmacology, 226(4), 649-658.
    DOI Scopus12 WoS11 Europe PMC7
    2013 Reichelt, A., & Lee, J. (2013). Appetitive Pavlovian goal-tracking memories reconsolidate only under specific conditions. Learning and Memory, 20(1), 51-60.
    DOI Scopus20 WoS19 Europe PMC12
    2013 Reichelt, A., Exton-McGuinness, M., & Lee, J. (2013). Ventral tegmental dopamine dysregulation prevents appetitive memory destabilization. Journal of Neuroscience, 33(35), 14205-14210.
    DOI Scopus32 WoS31 Europe PMC21
    2012 Reichelt, A., Rodgers, R., & Clapcote, S. (2012). The role of neurexins in schizophrenia and autistic spectrum disorder. Neuropharmacology, 62(3), 1519-1526.
    DOI Scopus63 WoS57 Europe PMC45
    2011 Reichelt, A., Lin, T., Harrison, J., Honey, R., & Good, M. (2011). Differential role of the hippocampus in response-outcome and context-outcome learning: Evidence from selective satiation procedures. Neurobiology of Learning and Memory, 96(2), 248-253.
    DOI Scopus5 WoS5 Europe PMC4
  • Book Chapters

    Year Citation
    2015 Reichelt, A., & Dachtler, J. (2015). The role of neurexins and neuroligins in autism. In The Molecular Basis of Autism (pp. 361-381).
    DOI

2021 – 2025     National Health and Medical Research Council (NHMRC) Investigator Grant - Emerging Leader - Harnessing the extracellular matrix to fight obesity-induced cognitive impairment - $650K AUD

2020 – 2021     Neurosurgical Research Foundation (NSF) (CIA) - The role of diet in mediating the effect on cognitive impairment and cortical perineuronal net alterations following traumatic brain injury - $30K AUD. CIB Dr Frances Corrigan, CIC A/Prof Lyndsey Collins-Praino

2018 – 2020      BrainsCAN Tier 1 Fellowship - $225K CAD

2018 – 2021     Australian Research Council Discovery Project (Primary CI) - Functional impact of high energy diets on memory encoding. CI Prof Anthony Hannan (Florey Department, University of Melbourne) - $428K AUD

2018 – 2021     National Health and Medical Research Council (NHMRC) Project Grant (CIE) - Novel pharmacological strategies to treat cognitive dysfunction in COPD. CIA Prof Ross Vlahos - $872K AUD

2018                RMIT Transitional Research Grants for Teaching and Research Staff (CIB) - Early gastrointestinal microbiota determinants of child behaviour at age 2. CIA Dr Amy Loughman $10K AUD

2016                RMIT Strategic Equipment and Infrastructure Grant (Lead Investigator) - Touchscreen suite and digital stereotaxic equipment. $76K AUD

2015                UNSW Science Early Career Grant (Sole CI) - Impact of sucrose bingeing in adolescent rats on brain reward system connectivity. $7.3K AUD

2014 – 2017     Australian Research Council Discovery Early Career Research Award (Sole CI) - Does obesity alter psychological associations to food related cues, contexts and responses? $375K AUD


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