Dr Amy Dwyer
Research Fellow- DRMCRL
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.
Dr. Amy R. Dwyer is a Research Fellow at the Dame Roma Mitchell Cancer Research Laboratories (DRMCRL), Adelaide Medical School, University of Adelaide. In 2016 Dr Dwyer was awarded her PhD at the University of Western Australia under the supervision of Dr. Fiona J. Pixley, PhD, MBBS. Her research project was focused on elucidating Src Family Kinase signaling in tumour-associated macrophages (TAM) and how they mediate TAM motility; this work resulted in 4 first author and 3 co-author peer-reviewed publications. Dr. Dwyer subsequently undertook Postdoctoral Research training at the University of Minnesota Masonic Cancer Center, under the guidance of Dr. Carol A. Lange, PhD. Here, Dr. Dwyer focused on steroid and growth factor receptor signaling as part of unexpected or unique transcriptional complexes in breast cancer progression. In 2019 Dr. Dwyer moved to the DRMCRL where she continues to work on steroid receptor signaling in breast biology and cancer.
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Appointments
Date Position Institution name 2016 - 2019 Postdoctoral Research Associate University of Minnesota -
Education
Date Institution name Country Title 2012 - 2016 University of Western Australia Australia PhD 2008 - 2012 University of Western Australia Australia BSc (Hons) -
Postgraduate Training
Date Title Institution Country 2019 - 2019 Big Data Training for Translational Omics Research Purdue University United States 2018 - 2018 Introduction to Computing in Biology University of Minnesota United States -
Research Interests
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Journals
Year Citation 2021 Dwyer, A. R., Truong, T. H., Kerkvliet, C. P., Paul, K. V., Kabos, P., Sartorius, C. A., & Lange, C. A. (2021). Insulin receptor substrate-1 (IRS-1) mediates progesterone receptor-driven stemness and endocrine resistance in oestrogen receptor+ breast cancer. British Journal of Cancer, 124(1), 217-227.
2021 Dwyer, A. R., Kerkvliet, C. P., Krutilina, R. I., Playa, H. C., Parke, D. N., Thomas, W. A., . . . Lange, C. A. (2021). Breast tumor kinase (Brk/PTK6) mediates advanced cancer phenotypes via SH2-Domain dependent activation of RhoA and aryl hydrocarbon receptor (AhR) signaling. Molecular Cancer Research, 19(2), 329-345.
2020 Perez Kerkvliet, C., Dwyer, A. R., Diep, C. H., Oakley, R. H., Liddle, C., Cidlowski, J. A., & Lange, C. A. (2020). Glucocorticoid receptors are required effectors of TGFβ1-induced p38 MAPK signaling to advanced cancer phenotypes in triple-negative breast cancer. Breast Cancer Research, 22(1), 39.
Scopus4 WoS4 Europe PMC12020 Dwyer, A., Truong, T., Ostrander, J., & Lange, C. (2020). Steroid receptors as MAPK signaling sensors in breast cancer: Let the fates decide. Journal of Molecular Endocrinology, 65(1), T35-T48.
Scopus3 WoS3 Europe PMC22020 Poh, A. R., Dwyer, A. R., Eissmann, M. F., Chand, A. L., Baloyan, D., Boon, L., . . . Ernst, M. (2020). Inhibition of the SRC kinase HC impairs STAT3-dependent gastric tumor growth in mice. Cancer Immunology Research, 8(4), 428-435.
Scopus4 WoS2 Europe PMC12019 Dwyer, A. R., Truong, T. H., Diep, C. H., Hu, H., Hagen, K. M., & Lange, C. A. (2019). Phosphorylated Progesterone Receptor Isoforms Mediate Opposing Stem Cell and Proliferative Breast Cancer Cell Fates. Endocrinology, 160(2), 430-446.
Scopus16 WoS17 Europe PMC82018 McGonigle, T. A., Dwyer, A. R., Greenland, E. L., Scott, N. M., Carter, K. W., Keane, K. N., . . . Hart, P. H. (2018). Reticulon-1 and reduced migration toward chemoattractants by macrophages differentiated from the bone marrow of ultraviolet-irradiated and ultraviolet-chimeric mice. Journal of immunology, 200(1), 260-270.
Scopus6 WoS6 Europe PMC32017 McGonigle, T. A., Dwyer, A. R., Greenland, E. L., Scott, N. M., Keane, K. N., Newsholme, P., . . . Hart, P. H. (2017). PGE2 pulsing of murine bone marrow cells reduces migration of daughter monocytes/macrophages in vitro and in vivo.. Experimental hematology, 56, 64-68.
Scopus3 WoS3 Europe PMC22017 McGonigle, T. A., Keane, K. N., Ghaly, S., Carter, K. W., Anderson, D., Scott, N. M., . . . Hart, P. H. (2017). UV irradiation of skin enhances glycolytic flux and reduces migration capabilities in bone marrow-differentiated dendritic cells. The American Journal of Pathology, 187(9), 2046-2059.
Scopus6 WoS6 Europe PMC52017 Dwyer, A. R., Greenland, E. L., & Pixley, F. J. (2017). Promotion of tumor invasion by tumor-associated macrophages: the role of CSF-1-activated phosphatidylinositol 3 kinase and Src family kinase motility signaling. Cancers, 9(6), 68.
Scopus23 WoS22 Europe PMC102016 Dwyer, A. R., Ellies, L. G., Holme, A. L., & Pixley, F. J. (2016). A three-dimensional co-culture system to investigate macrophage-dependent tumor cell invasion.. Journal of biological methods, 3(3), e49.
Europe PMC12016 Dwyer, A. R., Mouchemore, K. A., Steer, J. H., Sunderland, A. J., Sampaio, N. G., Greenland, E. L., . . . Pixley, F. J. (2016). Src family kinase expression and subcellular localization in macrophages: implications for their role in CSF-1-induced macrophage migration. Journal of Leukocyte Biology, 100(1), 163-175.
Scopus12 WoS12 Europe PMC112014 Sullivan, A. R., & Pixley, F. J. (2014). CSF-1R Signaling in Health and Disease: A Focus on the Mammary Gland. JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 19(2), 149-159.
WoS16 Europe PMC11
CTSI Translational Research Development Program Fellow
University of Minnesota, Clinical and Translational Science Institute
2018 - 2020
PHAR2210 Ethical Conduct Tutorials
Department of Medicine and Pharmacology, University of Western Australia
2014 - 2016
PHAR3311 & 3321 Pharmacology Methods
Department of Medicine and Pharmacology, University of Western Australia
2012 - 2016
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2021 Co-Supervisor Exploring the Role of Steroid Receptors in ER+ Breast Cancer Doctor of Philosophy Doctorate Full Time Mr Alex Adrian Pace 2020 Co-Supervisor Role of the GATA3 transcription factor on AR signalling In ER-positive breast cancer Doctor of Philosophy Doctorate Full Time Mrs Leila HosseinZadeh -
Mentoring
Date Topic Location Name 2017 - ongoing MD/PhD Student University of Minnesota Carlos Perez Kerkvliet 2014 - 2014 Honours Student University of Western Australia Eloise Greenland
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Committee Memberships
Date Role Committee Institution Country 2018 - ongoing Member Steering Committee Great Lakes Nuclear Receptor Conference 2018 University of Minnesota United States -
Memberships
Date Role Membership Country 2019 - ongoing Member Australian Society for Medical Research Australia 2016 - ongoing Member American Association of Cancer Research United States 2016 - ongoing Member Endocrine Society United States 2016 - ongoing Member Graduate Women in Science United States 2013 - 2016 Member Australian Society of Cell and Developmental Biology Australia
Connect With Me
External Profiles
