Aimee Horsfall

Ms Aimee Horsfall

Higher Degree by Research Candidate

Postgraduate Student

School of Physical Sciences

Faculty of Sciences


Aimee graduated from a Bachelor of Science (Molecular & Drug Design) in Chemistry at the University of Adelaide in 2015. She then went on to complete a Master of Philosophy in Chemical Science at the University of Adelaide, with a focus on constraining peptide secondary structure with a fluorescent linker, under the supervision of Professor Andrew Abell. Continuing under Professor Abell's guidance and co-supervised by Dr. John Bruning, Aimee is currently undertaking a PhD in Chemistry developing peptide therapeutic inhibitors of the DNA-replication regulator protein, PCNA. Aimee is a member of the ARC Centre of Excellence for Nanoscale Biophotonics (CNBP) and the Institute for Photonics & Advanced Sensing (IPAS) and is involved in collaborative projects developing peptide-based fluorescent probes and materials for a variety of applications.

The research focus of my PhD encompasses designing and synthesising peptides. My main project looks at using short peptides to probe the interaction interface of the key DNA-replication regulator protein, PCNA. Through understanding the structure and tolerance of the PCNA binding site, we can design new peptide-based therapeutics for treatment of diseases where DNA-replication is erroneous, including use as a broad-spectrum cancer treatment. I have experience in defining and characterising the secondary structure of peptide mimics, including development of a fluorescent peptide constraint to induce helicity in short peptides. As part of my work with the ARC Centre of Excellence for Nanoscale Biophotonics (CNBP) and the Institute for Photonics & Advanced Sensing (IPAS) I have worked on projects to design and synthesise peptide-based probes which have a turn-on fluorescence response in the presence of the target protein, and developing functional peptide-based materials to enable sensing platforms. 

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  • Journals

    Year Citation
    2019 Horsfall, A. J., Abell, A. D., & Bruning, J. (2019). Targeting PCNA with peptide mimetics for therapeutic purposes.. Chembiochem : a European journal of chemical biology.
    DOI

Aimee demonstrates undergraduate chemistry practical labs on a weekly basis during the University semesters, and is also involved with leading undergraduate chemistry workshops. 

  • Position: Postgraduate Student
  • Phone: 83166285
  • Email: aimee.horsfall@adelaide.edu.au
  • Fax: 8313 4380
  • Campus: North Terrace
  • Building: The Braggs, floor 1
  • Room: 1 - pod
  • Org Unit: Chemistry

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