Adeline Bowen
Adelaide Medical School
Faculty of Health and Medical Sciences
My research focuses on studying the pathogenesis and evaluating various treatments in cellular and animal models of dementia. These include viral vector gene transfer, stem cell-based therapies and small molecule drugs for mucopolysaccharidosis (MPS) IIIA, an early-onset neurological lysosomal storage disorder for which there is no treatment. I also have an interest in mouse behavioural phenotyping, given the importance of determining the effect of any future therapy in delaying, improving or normalising clinical symptoms. Over this time, I have line managed one Research Scientist and co-supervised four Honours/PhD students. More recently, I have collaborated on a project investigating the role of the endosomal/lysosomal system in the late-onset dementia, Alzheimer’s Disease.
-
Appointments
Date Position Institution name 2016 - ongoing Affiliate Lecture The University of Adelaide 2013 - ongoing Research Officer South Australian Health and Medical Research Institute 2007 - 2013 Post-doctoral Scientist SA Pathology (Women’s and Children’s Hospital site) 2004 - 2004 Visiting Scientist Institut de Génétique Moléculaire de Montpellier 2001 - 2003 Research Assistant Children’s Youth and Women’s Health Service -
Awards and Achievements
Date Type Title Institution Name Country Amount 2018 Award SAHMRI Translation and Impact Award SAHMRI Australia - 2017 Award Alice Davey Award The University of Adelaide Australia - -
Language Competencies
Language Competency English Can read, write, speak, understand spoken and peer review -
Education
Date Institution name Country Title University of Adelaide Australia PhD Flinders University Australia BBiotech (Hons) -
Research Interests
-
Journals
Year Citation 2024 Lau, A. A., Trim, P. J., King, B. M., Hassiotis, S., Hung, Y. H., Bush, A. I., . . . Hemsley, K. M. (2024). Filipin complex-reactive brain lesions: a cautionary tale. Neuropathology and Applied Neurobiology, 50(1), e12950-1-e12950-8.
2024 Lau, A. A., Jin, K., Beard, H., Windram, T., Xie, K., O’Brien, J. A., . . . Austin, P. J. (2024). Photobiomodulation in the infrared spectrum reverses the expansion of circulating natural killer cells and brain microglial activation in Sanfilippo mice. Journal of Neurochemistry, 168(9), 2791-2813.
2024 Beard, H., Winner, L., Shoubridge, A., Parkinson-Lawrence, E., Lau, A. A., Mubarokah, S. N., . . . Hemsley, K. M. (2024). Evaluation of neuroretina following i.v. or intra-CSF AAV9 gene replacement in mice with MPS IIIA, a childhood dementia. CNS Neuroscience and Therapeutics, 30(8), 13 pages.
2023 Tan, S. L., Hewson, L., Mustaffar, N. F., He, Q. Q., Wimmer, N., Trim, P., . . . Lau, A. (2023). Substrate reduction therapy in a<i>Drosophila melanogaster</i>model of Sanfilippo syndrome.
2022 Lau, A. A., Strebe, J. K., Sura, T., Hansen, L. A., & Jain, M. K. (2022). Predictors of linkage to hepatitis C virus care among people living with HIV with hepatitis C infection and the impact of loss to HIV follow-up. HEALTH SCIENCE REPORTS, 5(3), 11 pages.
2022 Whyte, L. S., Fourrier, C., Hassiotis, S., Lau, A. A., Trim, P. J., Hein, L. K., . . . Sargeant, T. J. (2022). Lysosomal gene Hexb displays haploinsufficiency in a knock-in mouse model of Alzheimer's disease. IBRO Neuroscience Reports, 12, 131-141.
Scopus8 WoS6 Europe PMC72021 Jolly, R. D., Hunter, S. A., Alley, M. R., King, B. M., Lau, A. A., Trim, P. J., . . . Hemsley, K. M. (2021). Mucopolysaccharidosis II (MPS II) in a free-living kaka (nestor meridionalis) in New Zealand. Journal of Wildlife Diseases, 57(4), 884-890.
Scopus3 WoS1 Europe PMC12020 Hocquemiller, M., Hemsley, K. M., Douglass, M. L., Tamang, S. J., Neumann, D., King, B. M., . . . Laufer, R. (2020). AAVrh10 Vector Corrects Disease Pathology in MPS IIIA Mice and Achieves Widespread Distribution of SGSH in Large Animal Brains. Molecular Therapy Methods and Clinical Development, 17, 174-187.
Scopus25 WoS15 Europe PMC172020 Whyte, L. S., Hassiotis, S., Hattersley, K. J., Hemsley, K. M., Hopwood, J. J., Lau, A. A., & Sargeant, T. J. (2020). Lysosomal Dysregulation in the Murine App<sup>NL-G-F/NL-G-F</sup> Model of Alzheimer's Disease. Neuroscience, 429, 143-155.
Scopus12 WoS10 Europe PMC82019 Lau, A. A., Hopwood, J. J., & Hemsley, K. M. (2019). Canine adenoviral vector-mediated gene transfer to the guinea pig brain. Gene Reports, 16, 100432-1-100432-5.
Scopus1 WoS12019 He, Q. Q., Trim, P. J., Lau, A. A., King, B. M., Hopwood, J. J., Hemsley, K. M., . . . Ferro, V. (2019). Synthetic disaccharide standards enable quantitative analysis of stored heparan sulfate in MPS IIIA murine brain regions. ACS Chemical Neuroscience, 10(8), 3847-3858.
Scopus13 WoS7 Europe PMC72018 Lau, A. A., Tamang, S. J., & Hemsley, K. M. (2018). MPS-IIIA mice acquire autistic behaviours with age. Journal of Inherited Metabolic Disease, 41(4), 669-677.
Scopus11 WoS8 Europe PMC82017 Lau, A. A., & Hemsley, K. M. (2017). Adeno-associated viral gene therapy for mucopolysaccharidoses exhibiting neurodegeneration. Journal of Molecular Medicine, 95(10), 1043-1052.
Scopus7 WoS5 Europe PMC42017 Hemsley, K., & Lau, A. (2017). Intracerebral gene therapy for mucopolysaccharidosis type IIIB syndrome. The Lancet Neurology, 16(9), 681-682.
2017 Whyte, L. S., Lau, A. A., Hemsley, K. M., Hopwood, J. J., & Sargeant, T. J. (2017). Endo-lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?. Journal of Neurochemistry, 140(5), 703-717.
Scopus105 WoS95 Europe PMC792017 Lau, A. A., King, B. M., Thorsen, C. L., Hassiotis, S., Beard, H., Trim, P. J., . . . Hemsley, K. M. (2017). A novel conditional Sgsh knockout mouse model recapitulates phenotypic and neuropathic deficits of Sanfilippo syndrome. Journal of Inherited Metabolic Disease, 40(5), 715-724.
Scopus12 WoS8 Europe PMC62017 Whyte, L. S., Hemsley, K. M., Lau, A. A., Hassiotis, S., Saito, T., Hopwood, J. J., & Sargeant, T. J. (2017). Reduction in open field activity in the absence of memory deficits in the AppNL-G-F knock-in mouse model of Alzheimer’s disease. Behavioural Brain Research, 336, 177-181.
Scopus50 WoS44 Europe PMC332016 Winner, L. K., Beard, H., Hassiotis, S., Lau, A. A., Luck, A. J., Hopwood, J. J., & Hemsley, K. M. (2016). A preclinical study evaluating AAVrh10-based gene therapy for Sanfilippo syndrome. Human Gene Therapy, 27(5), 363-375.
Scopus40 WoS35 Europe PMC282015 Whyte, L. S., Hopwood, J. J., Hemsley, K. M., & Lau, A. A. (2015). Variables influencing fluorimetric N-sulfoglucosamine sulfohydrolase (SGSH) activity measurement in brain homogenates. Molecular Genetics and Metabolism Reports, 5, 60-62.
Scopus6 WoS4 Europe PMC52014 Trim, P., Lau, A., Hopwood, J., & Snel, M. (2014). A simple method for early age phenotype confirmation using toe tissue from a mouse model of MPS IIIA. Rapid Communications in Mass Spectrometry, 28(8), 933-938.
Scopus25 WoS23 Europe PMC152013 Lau, A., Shamsani, N., Winner, L., Hassiotis, S., King, B., Hopwood, J., & Hemsley, K. (2013). Neonatal bone marrow transplantation in MPS IIIA mice. JIMD Reports, 8, 121-132.
Scopus21 Europe PMC152012 Lau, A., Rozaklis, T., Ibanes, S., Luck, A., Beard, H., Hassiotis, S., . . . Hemsley, K. (2012). Helper-dependent canine adenovirus vector-mediated transgene expression in a neurodegenerative lysosomal storage disorder. Gene, 491(1), 53-57.
Scopus24 WoS21 Europe PMC172010 Lau, A., Hannouche, H., Rozaklis, T., Hassiotis, S., Hopwood, J., & Hemsley, K. (2010). Allogeneic stem cell transplantation does not improve neurological deficits in mucopolysaccharidosis type IIIA mice. Experimental Neurology, 225(2), 445-454.
Scopus32 WoS30 Europe PMC262010 Lau, A., Hopwood, J., Kremer, E., & Hemsley, K. (2010). SGSH gene transfer in mucopolysaccharidosis type IIIA mice using canine adenovirus vectors. Molecular Genetics and Metabolism, 100(2), 168-175.
Scopus26 WoS26 Europe PMC162008 Lau, A., Crawley, A., Hopwood, J., & Hemsley, K. (2008). Open field locomotor activity and anxiety-related behaviors in mucopolysaccharidosis type IIIA mice. Behavioural Brain Research, 191(1), 130-136.
Scopus63 WoS57 Europe PMC452007 Fraldi, A., Hemsley, K., Crawley, A., Lombardi, A., Lau, A., Sutherland, L., . . . Hopwood, J. (2007). Functional correction of CNS lesions in an MPS-IIIA mouse model by intracerebral AAV-mediated delivery of sulfamidase and SUMF1 genes. Human Molecular Genetics, 16(22), 2693-2702.
Scopus103 WoS104 Europe PMC752006 Lau, A., Hemsley, K., Meedeniya, A., Robinson, A., & Hopwood, J. (2006). Directed differentiation and characterization of genetyically modified embryonic stem cells for therapy. Methods in Molecular Biology, 329, 471-484.
Scopus22004 Lau, A., Hemsley, K., Meedeniya, A., & Hopwood, J. (2004). In vitro characterization of genetically modified embryonic stem cells as a therapy for murine mucopolysaccharidosis type IIIA. Molecular Genetics and Metabolism, 81(2), 86-95.
Scopus7 WoS4 Europe PMC6
-
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2018 - 2020 Co-Supervisor The Role of Heterozygous Lysosomal Storage Disorder Alleles as Risk Factors for Dementia Doctor of Philosophy Doctorate Full Time Ms Lauren Sue Whyte -
Other Supervision Activities
Date Role Research Topic Location Program Supervision Type Student Load Student Name 2017 - 2017 Principal Supervisor Evaluation of a novel drug for the treatment of childhood-onset dementia The University of Adelaide - Honours Full Time Sher Li Tan 2010 - 2010 Co-Supervisor Assessment of the Migration of Donor-Derived Cells into the MPS IIIA Mouse Brain The University of Adelaide - Honours Full Time Noor Jannah Shamsani 2010 - 2010 Co-Supervisor Investigation of olfactory ensheathing cells as a potential treatment for Mucopolysaccharidosis type IIIA The University of Adelaide - Honours Full Time Vonny Williem Oey
Connect With Me
External Profiles
