Yoon Lim

Dr Yoon Lim

Research Fellow

Centre for Cancer Biology

College of Health

Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.


 Dr Yoon Lim is Research Fellow at the Centre for Cancer Biology (CCB), UniSA and SA Pathology. Yoon has over 11 years of experience in cell death in neurobiology and cancer biology.  Yoon completed his PhD in Neuroscience in 2016 (University of South Australia). Yoon’s PhD project focused on the signalling mechanisms of neurotrophins and their importance in neuronal survival, proliferation, and neurological disorders, including glioma, resulting in 17 primary research articles (3 as first author).   Before his PhD, Yoon worked for a biotech company in South Korea (2000 – 2007). Yoon discovered several diagnostic marker candidates for autoimmune diseases and cancer and developed a novel system for detecting residual antibiotics in whole milk that was widely recognised and sold to several major dairy companies in South Korea. Since Oct 2016, Yoon has been working as a post-doctoral researcher in cell death and cancer biology. He has been working with internal and external collaborators under the mentorship of Prof Sharad Kumar. He spent the last 6 years to understand how the cell death protease, caspase-2, is regulated in response to replicative stress in tumour suppression. His projects led to several seminal findings providing new mechanistic insights into the regulation of caspase-2 activation in tumour suppression. The contribution of his studies to the cell death field was recognised with the ANZSCDB Early Researcher Award in 2020.  Yoon has authored 34 journal articles (9 first or corresponding authors) which have attracted over 1450 citations, and his h-index is 23. He has presented at over 25 national and international conferences and has organised several national/local/institutional scientific meetings. Yoon is currently co-supervising three students (PhD, Masters and Honours).  

Year Citation
2026 Shah, S. S., Manning, J. A., Lim, Y., Sinha, D., Murthy, A. M. V., Ganesan, R., . . . Kumar, S. (2026). NEDD4L-mediated Gasdermin D and E ubiquitination regulates cell death and tissue injury. Cell Death and Differentiation, 33(4), 699-716.
DOI Scopus3 WoS2
2026 Dorstyn, L., Lim, Y., Scanlan, J., McLennan, E., De Bellis, D., Katschner, M., . . . Kumar, S. (2026). Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice. Science Advances, 12(1), eaeb2571-1-eaeb2571-20.
DOI Scopus1 WoS1 Europe PMC1
2026 Shah, S. S., Manning, J. A., Lim, Y., Sinha, D., Murthy, A. M. V., Ganesan, R., . . . Kumar, S. (2026). Correction: NEDD4L-mediated Gasdermin D and E ubiquitination regulates cell death and tissue injury.. Cell Death Differ, 2 pages.
DOI
2025 Shabbar, M., Manning, J. A., Lim, Y., Shah, S. S., Sinha, D., Nikolic, A., . . . Kumar, S. (2025). Phospholipid scramblase 1 (PLSCR1) is a novel substrate of NEDD4-2 (NEDD4L) mediated ubiquitination. Cell Death Discovery, 11(1), 393-1-393-11.
DOI Scopus1 WoS2 Europe PMC2
2024 Nicolson, S., Manning, J. A., Lim, Y., Jiang, X., Kolze, E., Dayan, S., . . . Denton, D. (2024). The Drosophila ZNRF1/2 homologue, detour, interacts with HOPS complex and regulates autophagy. Communications Biology, 7(1), 183-1-183-24.
DOI Scopus6 WoS3 Europe PMC4
2024 Dawar, S., Benitez, M. C., Lim, Y., Dite, T. A., Yousef, J. M., Thio, N., . . . Clemons, N. J. (2024). Caspase-2 protects against ferroptotic cell death. Cell Death and Disease, 15(3), 182-1-182-12.
DOI Scopus18 WoS18 Europe PMC15
2024 Vora, S., Andrew, A., Kumar, R. P., Nazareth, D., Bonfim-Melo, A., Lim, Y., . . . Gabrielli, B. (2024). Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition. Cell Death and Disease, 15(11, article no. 810), 810-1-810-9.
DOI Scopus13 WoS10 Europe PMC8
2022 Kumar, S., Dorstyn, L., & Lim, Y. (2022). The role of caspases as executioners of apoptosis. Biochemical Society Transactions, 50(1), 33-45.
DOI Scopus59 WoS50 Europe PMC43
2022 Kutyna, M. M., Kok, C. H., Lim, Y., Tran, E. N. H., Campbell, D., Paton, S., . . . Hiwase, D. K. (2022). A senescence stress secretome is a hallmark of therapy-related myeloid neoplasm stromal tissue occurring soon after cytotoxic exposure. Leukemia, 36(11), 2678-2689.
DOI Scopus23 WoS22 Europe PMC19
2022 Kutyna, M. M., Kok, C. H., Lim, Y., Campbell, D., Paton, S., Thompson-Peach, C. A. L., . . . Hiwase, D. (2022). Senolytic Therapy Can Reverse Senescent Bone Marrow Stroma of Therapy-Related Myeloid Neoplasm. Blood, 140(Supplement 1), 9755-9756.
DOI WoS1
2021 Lim, Y., De Bellis, D., Sandow, J. J., Capalbo, L., D'Avino, P. P., Murphy, J. M., . . . Kumar, S. (2021). Phosphorylation by Aurora B kinase regulates caspase-2 activity and function.. Cell Death and Differentiation, 28(1), 349-366.
DOI Scopus30 WoS29 Europe PMC29
2021 Lim, Y., Dorstyn, L., & Kumar, S. (2021). The p53-caspase-2 axis in the cell cycle and DNA damage response. Experimental and Molecular Medicine, 53(4), 517-527.
DOI Scopus50 WoS45 Europe PMC42
2020 Li, H., Lin, L. Y., Zhang, Y., Lim, Y., Rahman, M., Beck, A., . . . Zhou, X. F. (2020). Pro-BDNF knockout causes abnormal motor behaviours and early death in mice. Neuroscience, 438, 145-157.
DOI Scopus14 WoS12 Europe PMC11
2019 Dorstyn, L., Hackett-Jones, E., Nikolic, A., Norris, M. D., Lim, Y., Toubia, J., . . . Kumar, S. (2019). Transcriptome profiling of caspase-2 deficient EµMyc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling. Cell Death and Disease, 10(2), 56-1-56-16.
DOI Scopus8 WoS7 Europe PMC8
2018 Saadipour, K., Mañucat-Tan, N. B., Lim, Y., Keating, D. J., Smith, K. S., Zhong, J. H., . . . Zhou, X. F. (2018). p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis. Journal of Neurochemistry, 144(3), 302-317.
DOI Scopus29 WoS27 Europe PMC28
2018 Lim, Y., Wu, L., Chen, S., Sun, Y., Vijayaraj, S., Yang, M., . . . Zhou, X. (2018). HAP1 is required for endocytosis and signalling of BDNF and its receptors in neurons. Molecular Neurobiology, 55(3), 1815-1830.
DOI Scopus28 WoS25 Europe PMC23
2018 Lim, Y., De Bellis, D., Dorstyn, L., & Kumar, S. (2018). p53 accumulation following cytokinesis failure in the absence of caspase-2. Cell Death and Differentiation, 25(11), 2050-2052.
DOI Scopus12 WoS11 Europe PMC11
2017 Dawar, S., Lim, Y., Puccini, J., White, M., Thomas, P., Bouchier-Hayes, L., . . . Kumar, S. (2017). Caspase-2-mediated cell death is required for deleting aneuploid cells. Oncogene, 36(19), 2704-2714.
DOI Scopus57 WoS54 Europe PMC55
2017 Lim, Y. Y., Rainey-Smith, S., Lim, Y., Laws, S. M., Gupta, V., Porter, T., . . . Maruff, P. (2017). BDNF Val66Met in preclinical Alzheimer's disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mBDNF. International Psychogeriatrics, 29(11), 1825-1834.
DOI Scopus22 WoS18 Europe PMC18
2017 Mackenzie, K. D., Lim, Y., Duffield, M. D., Chataway, T., Zhou, X. F., & Keating, D. J. (2017). Huntingtin-associated protein-1 (HAP1) regulates endocytosis and interacts with multiple trafficking-related proteins. Cellular Signalling, 35, 176-187.
DOI Scopus31 WoS30 Europe PMC28
2016 Mackenzie, K. D., Lumsden, A. L., Guo, F., Duffield, M. D., Chataway, T., Lim, Y., . . . Keating, D. J. (2016). Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking. Journal of Neurochemistry, 138(5), 710-721.
DOI Scopus23 WoS23 Europe PMC22
2016 Han, Y. C., Lim, Y., Duffieldl, M. D., Li, H., Liu, J., Abdul Manaph, N. P., . . . Zhou, X. F. (2016). Direct reprogramming of mouse fibroblasts to neural stem cells by small molecules. Stem Cells International, 2016(4304916), 4304916-1-4304916-11.
DOI Scopus53 WoS51 Europe PMC47
2015 Xiong, J., Zhou, L., Lim, Y., Yang, M., Zhu, Y., Wei Li, Z., . . . Zhou, X. (2015). Mature brain-derived neurotrophic factor and its receptor TrkB are upregulated in human glioma tissues. Oncology Letters, 10(1), 223-227.
DOI Scopus34 WoS35 Europe PMC30
2015 Lim, Y., & Kumar, S. (2015). A single cut to pyroptosis. Oncotarget, 6(35), 36926-36927.
DOI Scopus25 WoS21 Europe PMC18
2015 Johnson, M. E., Lim, Y., Senthilkumaran, M., Zhou, X. F., & Bobrovskaya, L. (2015). Investigation of tyrosine hydroxylase and BDNF in a low-dose rotenone model of Parkinson's disease. Journal of Chemical Neuroanatomy, 70, 33-41.
DOI Scopus33 WoS28 Europe PMC25
2015 Lim, Y., Zhong, J. H., & Zhou, X. F. (2015). Development of mature BDNF-specific sandwich ELISA. Journal of Neurochemistry, 134(1), 75-85.
DOI Scopus52 WoS48 Europe PMC46
2013 Xiong, J., Zhou, L., Yang, M., Lim, Y., Zhu, Y., Fu, D., . . . Zhou, X. (2013). ProBDNF and its receptors are upregulated in glioma and inhibit the growth of glioma cells in vitro. Neuro-Oncology, 15(8), 990-1007.
DOI Scopus64 WoS57 Europe PMC49
2013 Xiong, J., Zhou, L., Lim, Y., Yang, M., Zhu, Y., Li, Z., . . . Zhou, X. (2013). Mature BDNF promotes the growth of glioma cells in vitro. Oncology Reports, 30(6), 2719-2724.
DOI Scopus44 WoS40 Europe PMC35
2013 Zhou, L., Xiong, J., Lim, Y., Ruan, Y., Huang, C., Zhu, Y., . . . Zhou, X. F. (2013). Upregulation of blood proBDNF and its receptors in major depression. Journal of Affective Disorders, 150(3), 776-784.
DOI Scopus140 WoS128 Europe PMC113
2013 Saadipour, K., Yang, M., Lim, Y., Georgiou, K., Sun, Y., Keating, D., . . . Zhou, X. (2013). Amyloid beta₁–-₄₂ (Aβ₄₂) up-regulates the expression of sortilin via the p75NTR/RhoA signaling pathway. Journal of Neurochemistry, 127(2), 152-162.
DOI Scopus48 WoS42 Europe PMC43
2013 Yang, M., Virassamy, B., Vijayaraj, S., Lim, Y., Saadipour, K., Wang, Y., . . . Zhou, X. (2013). The intracellular domain of sortilin interacts with Amyloid precursor protein and regulates its lysosomal and lipid raft trafficking. PLoS One, 8(5), e63049-1-e63049-13.
DOI Scopus31 WoS28 Europe PMC29
2012 Yang, G., Yang, M., Lim, Y., Lu, J., Wang, T., Qi, J., . . . Zhou, X. (2012). Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons. Journal of Neurochemistry, 122(5), 1010-1022.
DOI Scopus33 WoS34 Europe PMC29
2012 Sun, Y., Lim, Y., Li, F., Liu, S., Lu, J. J., Haberberger, R., . . . Zhou, X. F. (2012). ProBDNF collapses neurite outgrowth of primary neurons by activating RhoA. PLoS ONE, 7(4), 1-12.
DOI Scopus136 WoS98 Europe PMC113
2011 Xu, Z. Q., Sun, Y., Li, H. Y., Lim, Y., Zhong, J. H., & Zhou, X. F. (2011). Endogenous proBDNF is a negative regulator of migration of cerebellar granule cells in neonatal mice. European journal of neuroscience, 33(8), 1376-1384.
DOI Scopus57 WoS53 Europe PMC48
2011 Yang, M., Lim, Y., Li, X., Zhong, J., & Zhou, X. (2011). Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processing. Journal of Biological Chemistry, 286(18), 16272-16284.
DOI Scopus68 WoS62 Europe PMC58
2011 Wang, Y., Wang, X., Lu, J., Li, Q., Gao, C., Liu, X., . . . Zhou, X. (2011). p75NTR regulates Aβ deposition by increasing Aβ production but inhibiting Aβ aggregation with its extracellular domain. Journal of Neuroscience, 31(6), 2292-2304.
DOI Scopus93 WoS86 Europe PMC82
2011 Wang, Y. J., Valadares, D., Sun, Y., Wang, X., Zhong, J. H., Liu, X. H., . . . Zhou, X. F. (2011). Erratum: Effects of proNGF on neuronal viability, neurite growth and amyloid-beta metabolism (Neurotoxicity Research (2010) 17 (257-267) DOI: 10.1007/s12640-009-9098-x). Neurotoxicity Research, 20(4), 402.
DOI WoS1
2010 WANG, Y., Valadares, D., Sun, Y., Wang, X., Zhong, J., Liu, X. H., . . . Zhou, X. F. (2010). Effects of proNGF on neuronal viability, neurite growth and amyloid-beta metabolism. Neurotoxicity research, 17(3), 257-267.
DOI Scopus36 WoS35 Europe PMC27

Year Citation
2022 Kumar, S., Lim, Y., & Dorstyn, L. (2022). Tumor and aneuploidy suppression by caspase-2. Poster session presented at the meeting of CANCER SCIENCE. WILEY.

Year Citation
2023 Dawar, S., Benitez, M. C., Lim, Y., Dite, T. A., Yousef, J. M., Thio, N., . . . Clemons, N. J. (2023). Caspase-2 protects against ferroptotic cell death.
DOI

Date Role Research Topic Program Degree Type Student Load Student Name
2025 Co-Supervisor New mechanisms regulating extracellular vesicle biogenesis Doctor of Philosophy Doctorate Full Time Miss Tong Li
2025 Co-Supervisor Exploring the mechanisms of age-related polyploidy in inflammation and liver cancer Doctor of Philosophy Doctorate Full Time Mr Manish Kumar Vuriti
2022 Co-Supervisor Identification and characterisation of NEDD4-2 regulated proteins in the renal tubular epithelia. - Doctorate Full Time Mrs Meriam Shabbar
2022 Co-Supervisor Modulation of NEDD4-2 expression and activity as a cellular mechanism for ameliorating kidney disease Doctor of Philosophy Doctorate Part Time Miss Diva Sinha

Date Role Research Topic Program Degree Type Student Load Student Name
2022 - 2026 Co-Supervisor Identification and characterisation of NEDD4-2 regulated proteins in the renal tubular epithelia. Doctor of Philosophy Doctorate Full Time Mrs Meriam Shabbar
2022 - 2024 Co-Supervisor The role for caspase-2 in mammary development and fat biology Master of Research (Medical Science) Master Part Time Michael Katschner

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