Sharad Kumar

Research Interests

Animal Physiology - Cell Biochemistry and Cell Biology Cancer Cell Biology Cell Development, Proliferation and Death Cell Metabolism Cancer Biology and Clinical Oncology

Prof Sharad Kumar

Bradley Distinguished Professor

Centre for Cancer Biology

College of Health

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Prior to AU (created by the merging of UniSA and UA), I first joined the University of South Australia (UniSA) in 2014 as Chair of Cancer Biology and Research Professor of Cell Biology.
 
After earning my PhD from the University of Adelaide (UA) and completing postdoctoral training at the University of Queensland, I held Research Scientist positions at CSIRO (Geelong), RIKEN (Tsukuba, Japan) and the Cancer Institute (Tokyo, Japan). I later returned to Adelaide to establish a research program at the Hanson Centre for Cancer Research at IMVS (which eventually became SA Pathology). In 2009, together with Angel Lopez, I co-founded the Centre for Cancer Biology (CCB), which I co-directed for approximately 11 years.
My research has been continuously supported by national and international fellowships for over three decades. Trained as a biochemist, molecular biologist, and cell biologist, I am deeply passionate about science and discovery. My current research focuses on the molecular mechanisms of disease, particularly cancer. Our work has led to foundational discoveries in two major areas of contemporary biomedical sciences: 'Cell Death' and 'Ubiquitin-dependent protein modification'. Some key contributions include:
Identification of the Nedd genes, including one of the first mammalian caspases (Nedd2/caspase-2)
Discovery of the Nedd4 family of ubiquitin ligases
Discovery of Nedd8, a ubiquitin-like protein central to the now widely recognised process of Neddylation
Elucidation of the Drosophila cell death machinery, including the discovery of 4 of 7 caspases and both Bcl-2-like proteins
Identification of Ndfip1 and Ndfip2 as adaptors/regulators of ubiquitin ligases
Discovery of a novel autophagy-dependent cell death program during development
These findings have advanced our understanding of various human diseases, including cancer, cardiovascular conditions, and kidney disorders. Our research has been published in approximately 300 articles, cited over 68,000 times, with a current H-index of 105 (Google Scholar). I have delivered more than 250 invited talks and seminars at national and international forums. Over the course of my career, I’ve had the privilege of mentoring 30 postdoctoral scientists, 32 laboratory staff, and 25 PhD students.

Cancer biology

Cell death modalities

Ubiquitination

Disease models and mechanisms

Cellular and molecular biology

Extracellular Vesicles (EVs)

Date Institution name Country Title
University of Adelaide Australia PhD

Year Citation
2026 Dorstyn, L., Lim, Y., Scanlan, J., McLennan, E., De Bellis, D., Katschner, M., . . . Kumar, S. (2026). Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice. Science Advances, 12(1), eaeb2571-1-eaeb2571-20.
DOI
2026 Shah, S. S., Manning, J. A., Lim, Y., Sinha, D., Murthy, A. M. V., Ganesan, R., . . . Kumar, S. (2026). Correction: NEDD4L-mediated Gasdermin D and E ubiquitination regulates cell death and tissue injury.. Cell Death Differ, 2 pages.
DOI
2026 Thyagarajan, N., Le Leu, R., Kumar, S., Jesudason, S., & Manning, J. A. (2026). Increased Urinary Extracellular Vesicles and Reduced Expression of NEDD4L in Patients With Type 2 Diabetes and Diabetic Nephropathy. Journal of Diabetes Research, 2026(1).
DOI
2025 Shabbar, M., Manning, J., Lim, Y., Shah, S., Sinha, D., Nikolic, A., . . . Kumar, S. (2025). Phospholipid scramblase 1 (PLSCR1) is a novel substrate of NEDD4-2 (NEDD4L) mediated ubiquitination. Cell Death Discovery, 11(1, article no. 393), 1-11.
DOI Scopus1 WoS1 Europe PMC1
2025 Shah, S. S., Manning, J. A., Lim, Y., Sinha, D., Murthy, A. M. V., Ganesan, R., . . . Kumar, S. (2025). NEDD4L-mediated Gasdermin D and E ubiquitination regulates cell death and tissue injury. Cell Death and Differentiation, online, 1-18.
DOI
2025 Shah, M. V., Hung, K., Baranwal, A., Kutyna, M. M., Al-Kali, A., Toop, C., . . . Hiwase, D. K. (2025). Evidence-based risk stratification of myeloid neoplasms harboring TP53 mutations. Blood Advances, 9(13), 3370-3380.
DOI Scopus10 WoS11 Europe PMC10
2025 Umargamwala, R., Nicolson, S., Manning, J., Carosi, J. M., Kumar, S., & Denton, D. (2025). Identification of new candidates regulating autophagy-dependent midgut degradation in Drosophila melanogaster. Cell Death Discovery, 11(181), 181-1-181-13.
DOI Scopus2 WoS2 Europe PMC2
2025 Shah, M. V., Hung, K., Baranwal, A., Wechalekar, G., Al-Kali, A., Toop, C. R., . . . Hiwase, D. (2025). Validation of the 5th edition of the World Health Organization and International Consensus Classification guidelines for TP53-mutated myeloid neoplasm in an independent international cohort. Blood Cancer Journal, 15(1), 88-1-88-11.
DOI Scopus5 WoS4 Europe PMC3
2025 Manning, J. A., Jesudason, S., Moretti, P. A. B., Pitson, S. M., Chou, A. S. Y., Shabbar, M., . . . Kumar, S. (2025). Nedd4-2 ablation in kidney improves glycaemic control in diabetic mice. Cell Death and Disease, 16(496), 1-23.
DOI Scopus2 WoS2 Europe PMC1
2025 Windley, S. P., Neirijnck, Y., Vidovic, D., Schwarz, Q., Kumar, S., Nef, S., & Wilhelm, D. (2025). NEDD4 promotes Sertoli cell proliferation and adult Leydig cell differentiation in the murine testis. Endocrinology, in press(9), 14 pages.
DOI Europe PMC1
2024 Vora, S., Andrew, A., Kumar, R. P., Nazareth, D., Bonfim-Melo, A., Lim, Y., . . . Gabrielli, B. (2024). Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition. Cell Death and Disease, 15(11, article no. 810), 810-1-810-9.
DOI Scopus7 WoS8 Europe PMC6
2024 Nicolson, S., Manning, J. A., Lim, Y., Jiang, X., Kolze, E., Dayan, S., . . . Denton, D. (2024). The Drosophila ZNRF1/2 homologue, detour, interacts with HOPS complex and regulates autophagy. Communications Biology, 7(1), 183-1-183-24.
DOI Scopus5 WoS3 Europe PMC4
2024 Umargamwala, R., Manning, J., Dorstyn, L., Denton, D., & Kumar, S. (2024). Understanding Developmental Cell Death Using Drosophila as a Model System. Cells, 13(4), 347-1-347-16.
DOI Scopus3 WoS3 Europe PMC2
2024 Welsh, J. A., Goberdhan, D. C. I., O'Driscoll, L., Buzas, E. I., Witwer, K. W., & Kumar, S. (2024). Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. Journal of Extracellular Vesicles, 13(2, article no. e12404), 1-84.
DOI Scopus2648 WoS2171 Europe PMC2432
2024 Dawar, S., Benitez, M. C., Lim, Y., Dite, T. A., Yousef, J. M., Thio, N., . . . Clemons, N. J. (2024). Caspase-2 protects against ferroptotic cell death. Cell Death and Disease, 15(3), 182-1-182-12.
DOI Scopus15 WoS15 Europe PMC15
2024 Carosi, J. M., Hein, L. K., Sandow, J. J., Dang, L. V. P., Hattersley, K., Denton, D., . . . Sargeant, T. J. (2024). Autophagy captures the retromer-TBC1D5 complex to inhibit receptor recycling. Autophagy, 20(4), 863-882.
DOI Scopus8 WoS8 Europe PMC11
2023 Anand, S., Nedeva, C., Chitti, S. V., Fonseka, P., Kang, T., Gangoda, L., . . . Mathivanan, S. (2023). The E3 ubiquitin ligase NEDD4 regulates chemoresistance to 5-fluorouracil in colorectal cancer cells by altering JNK signalling. Cell Death and Disease, 14(828), 828-1-828-11.
DOI Scopus9 WoS9 Europe PMC9
2023 Carosi, J. M., Denton, D., Kumar, S., & Sargeant, T. J. (2023). Receptor Recycling by Retromer. Molecular and Cellular Biology, 43(7), 317-334.
DOI Scopus19 WoS19 Europe PMC19
2023 Dagdeviren, S., Hoang, M. F., Sarikhani, M., Meier, V., Benoit, J. C., Okawa, M. C., . . . Lee, R. T. (2023). An Insulin-regulated Arrestin Domain Protein Controls Hepatic Glucagon Action. Journal of Biological Chemistry, 299(8), 105045-1-105045-16.
DOI Scopus7 WoS9 Europe PMC11
2023 Hiwase, D. K., Hahn, C. N., Tran, E. N. H., Chhetri, R., Baranwal, A., Al-Kali, A., . . . Shah, M. V. (2023). TP53 mutation in therapy-related myeloid neoplasm defines a distinct molecular subtype. Blood, 141(9), 1087-1091.
DOI Scopus34 WoS31 Europe PMC32
2023 Shah, M. V., Tran, E. N. H., Shah, S., Chhetri, R., Baranwal, A., Ladon, D., . . . Hiwase, D. K. (2023). TP53 mutation variant allele frequency of ≥10% is associated with poor prognosis in therapy-related myeloid neoplasms. Blood Cancer Journal, 13(1), 51-1-51-9.
DOI Scopus34 WoS34 Europe PMC33
2023 Vitale, I., Pietrocola, F., Guilbaud, E., Aaronson, S. A., Abrams, J. M., Adam, D., . . . Galluzzi, L. (2023). Apoptotic cell death in disease-Current understanding of the NCCD 2023. Cell Death and Differentiation, 30(5), 1097-1154.
DOI Scopus287 WoS266 Europe PMC249
2022 Kutyna, M. M., Kok, C. H., Lim, Y., Campbell, D., Paton, S., Thompson-Peach, C. A. L., . . . Hiwase, D. (2022). Senolytic Therapy Can Reverse Senescent Bone Marrow Stroma of Therapy-Related Myeloid Neoplasm. Blood, 140(Supplement 1), 9755-9756.
DOI
2022 Kumar, S., Dorstyn, L., & Lim, Y. (2022). The role of caspases as executioners of apoptosis. Biochemical Society Transactions, 50(1), 33-45.
DOI Scopus53 WoS46 Europe PMC43
2022 Windley, S. P., Mayère, C., McGovern, A. E., Harvey, N. L., Nef, S., Schwarz, Q., . . . Wilhelm, D. (2022). Loss of NEDD4 causes complete XY gonadal sex reversal in mice. Cell Death and Disease, 13(1), 75-1-75-10.
DOI Scopus5 WoS5 Europe PMC7
2022 Farooq, A. U., Gembus, K., Sandow, J. J., Webb, A., Mathivanan, S., Manning, J. A., . . . Kumar, S. (2022). K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis. Journal of Extracellular Vesicles, 11(2), e12188-1-e12188-15.
DOI Scopus14 WoS13 Europe PMC12
2022 Lohraseb, I., McCarthy, P., Secker, G., Marchant, C., Wu, J., Ali, N., . . . Schwarz, Q. (2022). Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodelling in neural crest cells. Nature Communications, 13(1), 1-18.
DOI Scopus7 WoS9 Europe PMC9
2022 Kutyna, M. M., Kok, C. H., Lim, Y., Tran, E. N. H., Campbell, D., Paton, S., . . . Hiwase, D. K. (2022). A senescence stress secretome is a hallmark of therapy-related myeloid neoplasm stromal tissue occurring soon after cytotoxic exposure. Leukemia, 36(11), 2678-2689.
DOI Scopus20 WoS18 Europe PMC18
2022 Shah, M. V., Hahn, C. N., Tran, E. N. H., Sharplin, K. M., Chhetri, R., Baranwal, A., . . . Hiwase, D. (2022). <i>TP53</i> Mutation Status Defines a Distinct Clinicopathological Entity of Therapy-Related Myeloid Neoplasm, Characterized By Genomic Instability and Extremely Poor Outcome. Blood, 140(Supplement 1), 9798-9799.
DOI WoS2
2021 Lim, Y., Dorstyn, L., & Kumar, S. (2021). The p53-caspase-2 axis in the cell cycle and DNA damage response. Experimental and Molecular Medicine, 53(4), 517-527.
DOI Scopus47 WoS43 Europe PMC42
2021 Manning, J. A., Shah, S. S., Nikolic, A., Henshall, T. L., Khew-Goodall, Y., & Kumar, S. (2021). The ubiquitin ligase NEDD4-2/NEDD4L regulates both sodium homeostasis and fibrotic signaling to prevent end-stage renal disease. Cell Death and Disease, 12(4), 398-1-398-16.
DOI Scopus22 WoS20 Europe PMC19
2021 Sheng, J., Kohno, S., Okada, N., Okahashi, N., Teranishi, K., Matsuda, F., . . . Takahashi, C. (2021). Treatment of retinoblastoma 1-intact hepatocellular carcinoma with cyclin-dependent kinase 4/6 inhibitor combination therapy. Hepatology, 74(4), 1971-1993.
DOI Scopus35 WoS34 Europe PMC32
2021 Foot, N. J., Gonzalez, M. B., Gembus, K., Fonseka, P., Sandow, J. J., Nguyen, T. T., . . . Kumar, S. (2021). Arrdc4‐dependent extracellular vesicle biogenesis is required for sperm maturation. Journal of Extracellular Vesicles, 10(8), e12113-1-e12113-21.
DOI Scopus25 WoS24 Europe PMC24
2021 Klionsky, D. J., Petroni, G., Amaravadi, R. K., Baehrecke, E. H., Kumar, S., & Pietrocola, F. (2021). Autophagy in major human diseases. EMBO Journal, 40(19, article no. e108863), 1-63.
DOI Scopus1310 WoS1224 Europe PMC1177
2021 Carosi, J. M., Nguyen, T. N., Lazarou, M., Kumar, S., & Sargeant, T. J. (2021). ATG8ylation of proteins: a way to cope with cell stress?. The Journal of Cell Biology, 220(11), 1-4.
DOI Scopus18 WoS17 Europe PMC22
2021 Xu, T., Nicolson, S., Sandow, J. J., Dayan, S., Jiang, X., Manning, J. A., . . . Denton, D. (2021). Cp1/cathepsin L is required for autolysosomal clearance in Drosophila. Autophagy, 17(10), 2734-2749.
DOI Scopus13 WoS14 Europe PMC17
2021 Shah, S. S., & Kumar, S. (2021). Adaptors as the regulators of HECT ubiquitin ligases. Cell Death Differ, 28(2), 455-472.
DOI Scopus31 WoS32 Europe PMC32
2021 Carosi, J. M., Denton, D., Kumar, S., & Sargeant, T. J. (2021). Retromer dysfunction at the nexus of tauopathies. Cell Death and Differentiation, 28(3), 884-889.
DOI Scopus15 WoS13 Europe PMC17
2021 Klionsky, D. J., Abdel Aziz, A. K., Abdelfatah, S., Abdellatif, M., Kumar, S., & Tong, C. K. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 17(1), 1-382.
DOI Scopus2112 WoS1977 Europe PMC2023
2021 Lim, Y., De Bellis, D., Sandow, J. J., Capalbo, L., D'Avino, P. P., Murphy, J. M., . . . Kumar, S. (2021). Phosphorylation by Aurora B kinase regulates caspase-2 activity and function.. Cell Death and Differentiation, 28(1), 349-366.
DOI Scopus28 WoS27 Europe PMC27
2021 Carosi, J. M., Hein, L. K., van den Hurk, M., Adams, R., Milky, B., Singh, S., . . . Sargeant, T. J. (2021). Retromer regulates the lysosomal clearance of MAPT/tau. Autophagy, 17(9), 2217-2237.
DOI Scopus30 WoS34 Europe PMC36
2020 Murthy, A. M. V., Robinson, N., & Kumar, S. (2020). Crosstalk between cGAS-STING signaling and cell death. Cell Death and Differentiation, 27(11), 2989-3003.
DOI Scopus143 WoS134 Europe PMC129
2020 Hos, N. J., Fischer, J., Hos, D., Hejazi, Z., Calabrese, C., Ganesan, R., . . . Robinson, N. (2020). TRIM21 Is Targeted for Chaperone-Mediated Autophagy during Salmonella Typhimurium Infection.. J Immunol, 205(9), 2456-2467.
DOI Scopus27 WoS25 Europe PMC19
2020 Xu, T., Jiang, X., Denton, D., & Kumar, S. (2020). Ecdysone controlled cell and tissue deletion. Cell Death and Differentiation, 27(1), 1-14.
DOI Scopus47 WoS45 Europe PMC42
2020 Manning, J. A., Shah, S. S., Henshall, T. L., Nikolic, A., Finnie, J., & Kumar, S. (2020). Dietary sodium modulates nephropathy in Nedd4-2-deficient mice. Cell Death and Differentiation, 27(6), 1832-1843.
DOI Scopus11 WoS11 Europe PMC11
2020 Denton, D., O'Keefe, L., & Kumar, S. (2020). Drosophila as a model to understand autophagy deregulation in human disorders. Progress in Molecular Biology and Translational Science, 172, 375-409.
DOI Scopus7 WoS7 Europe PMC6
2020 Kulathunga, N., Kohno, S., Linn, P., Nishimoto, Y., Horike, S. -I., Zaraiskii, M. I., . . . Takahashi, C. (2020). Peripubertal high-fat diet promotes c-Myc stabilization in mammary gland epithelium. Cancer Science, 111(7), 2336-2348.
DOI Scopus4 WoS4 Europe PMC6
2020 Manning, J. A., Windley, S. P., Sandow, J. J., Shah, S. S., Western, P., Wilhelm, D., & Kumar, S. (2020). Identification of novel interacting partners of the NEDD4 ubiquitin ligase in mouse testis.. Journal of Proteomics, 223(103830), 103830-1-103830-8.
DOI Scopus3 WoS3 Europe PMC3
2020 Kohno, S., Linn, P., Nagatani, N., Watanabe, Y., Kumar, S., Soga, T., & Takahashi, C. (2020). Pharmacologically targetable vulnerability in prostate cancer carrying RB1-SUCLA2 deletion. Oncogene, 39(34), 5690-5707.
DOI Scopus14 WoS14 Europe PMC13
2019 Denton, D., & Kumar, S. (2019). Autophagy-dependent cell death. Cell Death and Differentiation, 26(4), 605-616.
DOI Scopus657 WoS630 Europe PMC581
2019 Dorstyn, L., Hackett-Jones, E., Nikolic, A., Norris, M. D., Lim, Y., Toubia, J., . . . Kumar, S. (2019). Transcriptome profiling of caspase-2 deficient EµMyc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling. Cell Death and Disease, 10(2), 56-1-56-16.
DOI Scopus8 WoS7 Europe PMC7
2019 Denton, D., Xu, T., Dayan, S., Nicolson, S., & Kumar, S. (2019). Crosstalk between Dpp and Tor signaling coordinates autophagy-dependent midgut degradation. Cell Death and Disease, 10(2), 111-1-111-8.
DOI Scopus5 WoS5 Europe PMC7
2019 Anand, S., Samuel, M., Kumar, S., & Mathivanan, S. (2019). Ticket to a bubble ride: cargo sorting into exosomes and extracellular vesicles. BBA - Proteins and Proteomics, 1867(12), 140203-1-140203-10.
DOI Scopus244 WoS220 Europe PMC213
2019 Denton, D., Xu, T., Dayan, S., Nicolson, S., & Kumar, S. (2019). Dpp regulates autophagy-dependent midgut removal and signals to block ecdysone production. Cell Death and Differentiation, 26(4), 763-778.
DOI Scopus48 WoS47 Europe PMC44
2019 Xu, T., Denton, D., & Kumar, S. (2019). Hedgehog and Wingless signaling are not essential for autophagy-dependent cell death. Biochemical Pharmacology, 162(S1), 3-13.
DOI Scopus6 WoS6 Europe PMC7
2018 Denton, D., & Kumar, S. (2018). Ribophagy: New receptor discovered. Cell research, 28(7), 699-700.
DOI Scopus5 WoS4 Europe PMC4
2018 Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., . . . Manic, G. (2018). Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. Cell Death and Differentiation, 25(3), 486-541.
DOI Scopus5560 WoS5053 Europe PMC4805
2018 Lim, Y., De Bellis, D., Dorstyn, L., & Kumar, S. (2018). p53 accumulation following cytokinesis failure in the absence of caspase-2. Cell Death and Differentiation, 25(11), 2050-2052.
DOI Scopus12 WoS11 Europe PMC11
2018 Manning, J. A., & Kumar, S. (2018). Physiological functions of nedd4-2: lessons from knockout mouse models. Trends in Biochemical Sciences, 43(8), 635-647.
DOI Scopus62 WoS65 Europe PMC61
2018 Anand, S., Foot, N., Ang, C. S., Gembus, K. M., Keerthikumar, S., Adda, C. G., . . . Kumar, S. (2018). Arrestin-domain containing protein 1 (Arrdc1) regulates the protein cargo and release of extracellular vesicles. Proteomics, 18(17), 1800266-1-1800266-6.
DOI Scopus59 WoS51 Europe PMC46
2018 Dorstyn, L., Akey, C. W., & Kumar, S. (2018). New insights into apoptosome structure and function. Cell Death and Differentiation, 25(7), 1194-1208.
DOI Scopus184 WoS174 Europe PMC158
2018 Wilson, C. H., & Kumar, S. (2018). Caspases in metabolic disease and their therapeutic potential. Cell Death and Differentiation, 25(6), 1010-1024.
DOI Scopus74 WoS74 Europe PMC59
2018 Choi, S. (Ed.) (2018). Encyclopedia of Signaling Molecules.
DOI
2017 Galluzzi, L., Baehrecke, E. H., Ballabio, A., Boya, P., Kumar, S., & Kroemer, G. (2017). Molecular definitions of autophagy and related processes. The EMBO Journal, 36(13), 1811-1836.
DOI Scopus1446 WoS1341 Europe PMC1265
2017 Henshall, T., Manning, J., Alfassy, O., Goel, P., Boase, N., Kawabe, H., & Kumar, S. (2017). Deletion of Nedd4-2 results in progressive kidney disease in mice. Cell Death and Differentiation, 24(12), 2150-2160.
DOI Scopus31 WoS32 Europe PMC30
2017 Wilson, C., Nikolic, A., Kentish, S., Keller, M., Hatzinikolas, G., Dorstyn, L., . . . Kumar, S. (2017). Caspase-2 deficiency enhances whole-body carbohydrate utilisation and prevents high-fat diet-induced obesity. Cell Death and Disease, 8(10), e3136-1-e3136-12.
DOI Scopus16 WoS15 Europe PMC15
2017 Manning, J. A., Henshall, T. L., & Kumar, S. (2017). NEDD4-2-dependent control of Na⁺ homeostasis and renal disease. Cell cycle, 17(1), 1-2.
DOI Scopus8 WoS9 Europe PMC11
2017 Dawar, S., Lim, Y., Puccini, J., White, M., Thomas, P., Bouchier-Hayes, L., . . . Kumar, S. (2017). Caspase-2-mediated cell death is required for deleting aneuploid cells. Oncogene, 36(19), 2704-2714.
DOI Scopus56 WoS53 Europe PMC52
2017 Foot, N., Henshall, T., & Kumar, S. (2017). Ubiquitination and the regulation of membrane proteins. Physiological Reviews, 97(1), 253-281.
DOI Scopus211 WoS213 Europe PMC206
2017 Xu, T., Kumar, S., & Denton, D. (2017). Characterization of Autophagic Responses in Drosophila melanogaster. Methods in Enzymology, 588, 445-465.
DOI Scopus11 WoS11 Europe PMC10
2016 Foot, N., Gembus, K., MacKenzie, K., & Kumar, S. (2016). Ndfip2 is a potential regulator of the iron transporter DMT1 in the liver. Scientific Reports, 6(24045), 1-9.
DOI Scopus13 WoS12 Europe PMC12
2016 Mackenzie, K. D., Foot, N. J., Anand, S., Dalton, H. E., Chaudhary, N., Collins, B. M., . . . Kumar, S. (2016). Regulation of the divalent metal ion transporter via membrane budding. Cell Discovery, 2(1), 1-14.
DOI Scopus40 WoS39 Europe PMC36
2016 Camera, D., Coleman, H., Parkington, H., Jenkins, T., Pow, D., Boase, N., . . . Poronnik, P. (2016). Learning, memory and long-term potentiation are altered in Nedd4 heterozygous mice. Behavioural Brain Research, 303, 176-181.
DOI Scopus15 WoS15 Europe PMC14
2016 Yip, K., Kolesnikoff, N., Hauschild, N., Biggs, L., Lopez, A., Galli, S., . . . Grimbaldeston, M. (2016). The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation. Nature Communications, 7(article no. 13198), 13198-1-13198-14.
DOI Scopus33 WoS33 Europe PMC29
2016 Dawar, S., Shahrin, N., Sladojevic, N., D'Andrea, R., Dorstyn, L., Hiwase, D., & Kumar, S. (2016). Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice. Cell Death and Disease, 7(12), e2509-1-e2509-9.
DOI Scopus27 WoS28 Europe PMC29
2016 Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Arozena, A. A., . . . Bagniewska-Zadworna, A. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12(1), 1-222.
DOI Scopus4597 WoS3819 Europe PMC4164
2016 Wilson, C. H., Dorstyn, L., & Kumar, S. (2016). Fat, sex and caspase-2. Cell Death and Disease, 7(e2125), 1-2.
DOI Scopus2 WoS2 Europe PMC1
2016 Shalini, S., Nikolic, A., Wilson, C., Puccini, J., Sladojevic, N., Finnie, J., . . . Kumar, S. (2016). Caspase-2 deficiency accelerates chemically induced liver cancer in mice. Cell Death and Differentiation, 23(10), 1727-1736.
DOI Scopus37 WoS34 Europe PMC31
2016 Wilson, C., Nikolic, A., Kentish, S., Shalini, S., Hatzinikolas, G., Page, A., . . . Kumar, S. (2016). Sex-specific alterations in glucose homeostasis and metabolic parameters during ageing of caspase-2-deficient mice. Cell Death Discovery, 2(16009), 16009-1-16009-10.
DOI Scopus18 WoS18 Europe PMC15
2016 Meshram, I. I., Balakrishna, N., Sreeramakrishna, K., Rao, K. M., Kumar, R. H., Arlappa, N., . . . Laxmaiah, A. (2016). Trends in nutritional status and nutrient intakes and correlates of overweight/obesity among rural adult women (≥18-60 years) in India: National Nutrition Monitoring Bureau (NNMB) national surveys. Public Health Nutrition, 19(5), 767-776.
DOI Scopus21 Europe PMC19
2016 Galluzzi, L., López-Soto, A., Kumar, S., & Kroemer, G. (2016). Caspases connect cell-death signaling to organismal homeostasis. Immunity, 44(2), 221-231.
DOI Scopus316 WoS288 Europe PMC243
2015 Lim, Y., & Kumar, S. (2015). A single cut to pyroptosis. Oncotarget, 6(35), 36926-36927.
DOI Scopus25 WoS21 Europe PMC18
2015 Nicolson, S., Denton, D., & Kumar, S. (2015). Ecdysone-mediated programmed cell death in Drosophila. International Journal of Developmental Biology, 59(1-3), 23-32.
DOI Scopus45 WoS43 Europe PMC38
2015 Denton, D., & Kumar, S. (2015). Studying apoptosis in Drosophila. Cold Spring Harbor Protocols, 2015(7), 609-613.
DOI Scopus11 Europe PMC8
2015 Denton, D., & Kumar, S. (2015). Using synthetic peptide substrates to measure Drosophila caspase activity. Cold Spring Harbor Protocols, 2015(7), 671-674.
DOI Scopus2 Europe PMC1
2015 Denton, D., & Kumar, S. (2015). Analyzing the response of RNAI-treated drosophila cells to death stimuli by quantitative real-time polymerase chain reaction. Cold Spring Harbor Protocols, 2015(7), 666-671.
DOI Scopus3 Europe PMC3
2015 Denton, D., & Kumar, S. (2015). Immunostaining using an antibody against active caspase-3 to detect apoptotic cells in drosophila. Cold Spring Harbor Protocols, 6(6), 576-579.
DOI Scopus4 Europe PMC4
2015 Denton, D., & Kumar, S. (2015). Using the vital dye acridine orange to detect dying cells in drosophila. Cold Spring Harbor Protocols, 6(6), 572-574.
DOI Scopus11 Europe PMC8
2015 Xu, T., Nicolson, S., Denton, D., & Kumar, S. (2015). Distinct requirements of Autophagy-related genes in programmed cell death. Cell Death and Differentiation, 22(11), 1792-1802.
DOI Scopus66 WoS61 Europe PMC61
2015 Galluzzi, L., Pietrocola, F., Bravo-San Pedro, J., Amaravadi, R., Baehrecke, E., Cecconi, F., . . . Kroemer, G. (2015). Autophagy in malignant transformation and cancer progression. The EMBO Journal, 34(7), 856-880.
DOI Scopus1080 WoS1015 Europe PMC922
2015 Denton, D., Xu, T., & Kumar, S. (2015). Autophagy as a pro-death pathway. Immunology and Cell Biology, 93(1), 35-42.
DOI Scopus162 WoS154 Europe PMC133
2015 Goel, P., Manning, J., & Kumar, S. (2015). NEDD4-2 (NEDD4L): the ubiquitin ligase for multiple membrane proteins. Gene, 557(1), 1-10.
DOI Scopus147 WoS150 Europe PMC138
2015 Wilson, C., Shalini, S., Filipovska, A., Richman, T., Davies, S., Martin, S., . . . Kumar, S. (2015). Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice. Cell Death & Disease, 6(1), e1597-1-e1597-12.
DOI Scopus40 WoS39 Europe PMC36
2015 Shalini, S., Dorstyn, L., Dawar, S., & Kumar, S. (2015). Old, new and emerging functions of caspases. Cell Death and Differentiation, 22(4), 526-539.
DOI Scopus1093 WoS1027 Europe PMC879
2015 Galluzzi, L., Bravo-San Pedro, J., Vitale, I., Aaronson, S., Abrams, J., Adam, D., . . . Oberst, A. (2015). Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death and Differentiation, 22(1), 58-73.
DOI Scopus871 WoS815 Europe PMC706
2015 Peintner, L., Dorstyn, L., Kumar, S., Aneichyk, T., Villunger, A., & Manzl, C. (2015). The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd. Cell Death and Differentiation, 22(11), 1803-1811.
DOI Scopus23 WoS21 Europe PMC17
2015 Shalini, S., & Kumar, S. (2015). Caspase-2 and the oxidative stress response. Molecular & Cellular Oncology, 2(4), e1004956-1-e1004956-3.
DOI Scopus7 WoS7 Europe PMC4
2015 Denton, D., & Kumar, S. (2015). Terminal deoxynucleotidyl transferase (TdT)-mediated dutp nick-end labeling (TUNEL) for detection of apoptotic cells in Drosophila. Cold Spring Harbor Protocols, 2015(6), 568-571.
DOI Scopus19 Europe PMC17
2015 Boase, N., & Kumar, S. (2015). NEDD4: The founding member of a family of ubiquitin-protein ligases. Gene, 557(2), 113-122.
DOI Scopus128 WoS125 Europe PMC112
2014 Dorstyn, L., & Kumar, S. (2014). Caspase-2 protocols. Methods in Molecular Biology, 1133, 71-87.
DOI
2014 Dorstyn, L., Puccini, J., Nikolic, A., Shalini, S., Wilson, C., Norris, M., . . . Kumar, S. (2014). An unexpected role for caspase-2 in neuroblastoma. Cell Death and Disease, 5(8), e1383-1-e1383-9.
DOI Scopus21 WoS20 Europe PMC16
2014 Sandow, J., Dorstyn, L., O'Reilly, L., Tailler, M., Kumar, S., Strasser, A., & Ekert, P. (2014). ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis. Cell Death and Differentiation, 21(3), 475-480.
DOI Scopus52 WoS47 Europe PMC47
2014 Shalini, S., Puccini, J., Wilson, C., Finnie, J., Dorstyn, L., & Kumar, S. (2014). Caspase-2 protects against oxidative stress in vivo. Oncogene, 34(38), 4995-5002.
DOI Scopus33 WoS28 Europe PMC25
2014 Altin, J., Daley, S., Howitt, J., Rickards, H., Batkin, A., Horikawa, K., . . . Goodnow, C. (2014). Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4⁺ T cells. Proceedings of the National Academy of Sciences of the United States of America, 111(6), 2067-2074.
DOI Scopus20 WoS21 Europe PMC22
2014 Scheffner, M., & Kumar, S. (2014). Mammalian HECT ubiquitin-protein ligases: Biological and pathophysiological aspects. Biochimica et Biophysica Acta-Molecular Cell Research, 1843(1), 61-74.
DOI Scopus241 WoS230 Europe PMC221
2014 Camera, D., Boase, N., Kumar, S., Pow, D., & Poronnik, P. (2014). Subtle gait abnormalities in Nedd4 heterozygous mice. Behavioural Brain Research, 260, 15-24.
DOI Scopus10 WoS9 Europe PMC9
2014 Ekberg, J., Boase, N., Rychkov, G., Manning, J., Poronnik, P., & Kumar, S. (2014). Nedd4-2 (NEDD4L) controls intracellular Na⁺ -mediated activity of voltage-gated sodium channels in primary cortical neurons. Biochemical Journal, 457(1), 27-31.
DOI Scopus33 WoS33 Europe PMC32
2013 Denton, D., Aung Htut, M., & Kumar, S. (2013). Developmentally programmed cell death in Drosophila. Biochimica et Biophysica Acta-Molecular Cell Research, 1833(12), 3499-3506.
DOI Scopus64 WoS63 Europe PMC51
2013 Wiszniak, S., Kabbara, S., Lumb, R., Scherer, M., Secker, G., Harvey, N., . . . Schwarz, Q. (2013). The ubiquitin ligase Nedd4 regulates craniofacial development by promoting cranial neural crest cell survival and stem-cell like properties. Developmental Biology, 383(2), 186-200.
DOI Scopus27 WoS30 Europe PMC30
2013 Puccini, J., Dorstyn, L., & Kumar, S. (2013). Caspase-2 as a tumour suppressor. Cell Death and Differentiation, 20(9), 1133-1139.
DOI Scopus88 WoS84 Europe PMC70
2013 Puccini, J., Shalini, S., Voss, A., Gatei, M., Wilson, C., Hiwase, D., . . . Kumar, S. (2013). Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice. Proceedings of the National Academy of Sciences of the United States of America, 110(49), 19920-19925.
DOI Scopus64 WoS58 Europe PMC57
2013 Denton, D., Aung Htut, M., Lorensuhewa, N., Nicholson, S., Zhu, W., Mills, K., . . . Kumar, S. (2013). UTX coordinates steroid hormone-mediated autophagy and cell death. Nature Communications, 4(2916), 1-11.
DOI Scopus53 WoS48 Europe PMC38
2013 Puccini, J., Dorstyn, L., & Kumar, S. (2013). Genetic background and tumour susceptibility in mouse models. Cell Death and Differentiation, 20(7), 964.
DOI Scopus13 WoS13 Europe PMC13
2013 Liu, P., Xu, N., Malyukova, A., Scarlett, C., Sun, Y., Zhang, X., . . . Liu, T. (2013). The histone deacetylase SIRT2 stabilizes Myc oncoproteins. Cell Death and Differentiation, 20(3), 503-514.
DOI Scopus194 WoS176 Europe PMC164
2013 Ronzaud, C., Loffing-Cueni, D., Hausel, P., Debonneville, A., Malsure, S., Fowler-Jaeger, N., . . . Staub, O. (2013). Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension. Journal of Clinical Investigation, 123(2), 657-665.
DOI Scopus125 WoS127 Europe PMC114
2012 Garrick, M., Zhao, L., Roth, J., Jiang, H., Feng, J., Foot, N., . . . Garrick, L. (2012). Isoform specific regulation of divalent metal (ion) transporter (DMT1) by proteasomal degradation. Biometals, 25(4), 787-793.
DOI Scopus38 WoS34 Europe PMC31
2012 Denton, D., & Kumar, S. (2012). Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 8(4), 445-544.
DOI Scopus2994 WoS2674 Europe PMC2707
2012 Shalini, S., Dorstyn, L., Wilson, C., Puccini, J., Ho, L., & Kumar, S. (2012). Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice. Cell Death and Differentiation, 19(8), 1370-1380.
DOI Scopus82 WoS71 Europe PMC66
2012 Dorstyn, L., Puccini, J., Wilson, C., Shalini, S., Nicola, M., Moore, S., & Kumar, S. (2012). Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability. Cell Death and Differentiation, 19(8), 1288-1298.
DOI Scopus93 WoS90 Europe PMC84
2012 Denton, D., Chang, T., Nicolson, S., Shravage, B., Simin, R., Baehrecke, E., & Kumar, S. (2012). Relationship between growth arrest and autophagy in midgut programmed cell death in Drosophila. Cell Death and Differentiation, 19(8), 1299-1307.
DOI Scopus67 WoS62 Europe PMC64
2012 Howitt, J., Lackovic, J., Low, L., Naguib, A., Macintyre, A., Goh, C., . . . Tan, S. (2012). Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia. Journal of Cell Biology, 196(1), 29-36.
DOI Scopus93 WoS90 Europe PMC89
2012 Galluzzi, L., Vitale, I., Abrams, J., Alnemri, E., Baehrecke, E., Blagosklonny, M., . . . Kroemer, G. (2012). Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death and Differentiation, 19(1), 107-120.
DOI Scopus2179 WoS1992 Europe PMC1789
2012 Denton, D., Nicolson, S., & Kumar, S. (2012). Cell death by autophagy: facts and apparent artefacts. Cell Death and Differentiation, 19(1), 87-95.
DOI Scopus352 WoS340 Europe PMC305
2011 Boase, N., Rychkov, G., Townley, S., Dinudom, A., Candi, E., Voss, A., . . . Cook, D. (2011). Respiratory distress and perinatal lethality in Nedd4-2-deficient mice. Nature Communications, 2(1), 1-9.
DOI Scopus84 WoS79 Europe PMC76
2011 Dalton, H., Denton, D., Foot, N., Ho, K., Mills, K., Brou, C., & Kumar, S. (2011). Drosophila Ndfip is a novel regulator of Notch signaling. Cell Death and Differentiation, 18(7), 1150-1160.
DOI Scopus20 WoS20 Europe PMC25
2011 Lee, I., Song, S., Campbell, C., Kumar, S., Cook, D., & Dinudom, A. (2011). Regulation of the epithelial Na⁺ channel by the RH domain of G protein-coupled receptor kinase, GRK2, and Gαq/11. Journal of Biological Chemistry, 286(22), 19259-19269.
DOI Scopus13 WoS11 Europe PMC11
2011 Yuan, S., Yu, X., Topf, M., Dorstyn, L., Kumar, S., Ludtke, S., & Akey, C. (2011). Structure of the Drosophila apoptosome at 6.9 Å resolution. Structure, 19(1), 128-140.
DOI Scopus72 WoS65 Europe PMC58
2011 Foot, N., Leong, Y., Dorstyn, L., Dalton, H., Ho, K., Zhao, L., . . . Kumar, S. (2011). Ndfip1-deficient mice have impaired DMT1 regulation and iron homeostasis. Blood, 117(2), 638-646.
DOI Scopus41 WoS39 Europe PMC40
2010 Manning, J., & Kumar, S. (2010). A potential role for NEDD1 and the centrosome in senescence of mouse embryonic fibroblasts. Cell Death & Disease, 1(4), E35-1-E35-8.
DOI Scopus30 WoS32 Europe PMC33
2010 Hiwase, D., White, D., Powell, J., Saunders, V., Zrim, S., Frede, A., . . . Hughes, T. (2010). Blocking cytokine signaling along with intense Bcr-Abl kinase inhibition induces apoptosis in primary CML progenitors. Leukemia, 24(4), 771-778.
DOI Scopus48 WoS42 Europe PMC41
2010 Denton, D., Shravage, B., Simin, R., Baehrecke, E., & Kumar, S. (2010). Larval midgut destruction in Drosophila: Not dependent on caspases but suppressed by the loss of autophagy. Autophagy, 6(1), 163-165.
DOI Scopus54 WoS51 Europe PMC40
2010 Manning, J., Shalini, S., Risk, J., Day, C., & Kumar, S. (2010). A direct interaction with NEDD1 regulates γ-tubulin recruitment to the centrosome. PLoS One, 5(3), 1-12.
DOI Scopus40 WoS42 Europe PMC41
2010 Manning, J., Lewis, M., Koblar, S., & Kumar, S. (2010). An essential function for the centrosomal protein NEDD1 in zebrafish development. Cell Death and Differentiation, 17(8), 1302-1314.
DOI Scopus14 WoS14 Europe PMC14
2009 Kumar, S. (2009). Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?. Nature Reviews. Cancer, 9(12), 897-903.
DOI Scopus124 WoS123 Europe PMC109
2009 Denton, D., Shravage, B., Simin, R., Mills, K., Berry, D., Baehrecke, E., & Kumar, S. (2009). Autophagy, not apoptosis, is essential for midgut cell death in Drosophila. Current Biology, 19(20), 1741-1746.
DOI Scopus330 WoS324 Europe PMC291
2009 Kumar, S., & Dorstyn, L. (2009). Analysing caspase activation and caspase activity in apoptotic cells. Methods in Molecular Biology, 559, 3-17.
DOI Scopus17 Europe PMC12
2009 Howitt, J., Putz, U., Lackovic, J., Doan, A., Dorstyn, L., Cheng, H., . . . Tan, S. (2009). Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons. Proceedings of the National Academy of Sciences of the United States of America, 106(36), 15489-15494.
DOI Scopus103 WoS102 Europe PMC99
2009 Yang, B., & Kumar, S. (2009). Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions. Cell Death and Differentiation, 17(1), 68-77.
DOI Scopus195 WoS193 Europe PMC184
2009 Rotin, D., & Kumar, S. (2009). Physiological functions of the HECT family of ubiquitin ligases. Nature Reviews. Molecular Cell Biology, 10(6), 398-409.
DOI Scopus904 WoS874 Europe PMC836
2009 Ho, L., Taylor, R., Dorstyn, L., Cakouros, D., Bouillet, P., & Kumar, S. (2009). A tumor suppressor function for caspase-2. Proceedings of the National Academy of Sciences of the United States of America, 106(13), 5336-5341.
DOI Scopus154 WoS142 Europe PMC138
2009 Lee, I., Campbell, C., Song, S., Day, M., Kumar, S., Cook, D., & Dinudom, A. (2009). The Activity of the Epithelial Sodium Channels Is Regulated by Caveolin-1 via a Nedd4-2-dependent Mechanism. Journal of Biological Chemistry, 284(19), 12663-12669.
DOI Scopus51 WoS46 Europe PMC44
2009 Kochetkova, M., Kumar, S., & McColl, S. (2009). Chemokine receptors CXCR4 and CCR7 promote metastasis by preventing anoikis in cancer cells. Cell Death and Differentiation, 16(5), 664-673.
DOI Scopus87 WoS83 Europe PMC73
2009 Kroemer, G., Galluzzi, L., Vandenabeele, P., Abrams, J., Kumar, S., & Melino, G. (2009). Classification of cell death : recommendations of the Nomenclature Committee on Cell Death 2009. Cell death and differentiation, 16(1), 3-11.
DOI Scopus2498 WoS2350 Europe PMC1975
2009 Galluzzi, L., Aaronson, S. A., Abrams, J., Alnemri, E. S., Andrews, D. W., Baehrecke, E. H., . . . Kroemer, G. (2009). Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death and Differentiation, 16(8), 1093-1107.
DOI Scopus601 WoS552 Europe PMC485
2009 Hiwase, D., White, D., Saunders, V., Kumar, S., Melo, J., & Hughes, T. (2009). Short-term intense Bcr-Abl kinase inhibition with nilotinib is adequate to trigger cell death in BCR-ABL<sup>+</sup> cells. Leukemia, 23(6), 1205-1206.
DOI Scopus17 WoS16 Europe PMC13
2009 Dorstyn, L., & Kumar, S. (2009). Putative functions of caspase-2. F1000 biology reports, 1(96), 1-5.
DOI Europe PMC2
2008 Kumar, S., Khan, J. A., & Pathak, B. J. (2008). Population structure, home range and food habits of Hanuman langur in Gir Lion Sanctuary and National Park, India. International Journal of Ecology and Environmental Sciences, 34(2), 165-173.
2008 Ho, L., Read, S., Dorstyn, L., Lambrusco, L., & Kumar, S. (2008). Capase-2 is required for cell death induced by cytoskeletal disruption. Oncogene, 27(24), 3393-3404.
DOI Scopus112 WoS104 Europe PMC102
2008 Hiwase, D., Saunders, V., Hewett, D., Frede, A., Zrim, S., Dang, P., . . . White, D. (2008). Dasatinib cellular uptake and efflux in chronic myeloid leukemia cells: therapeutic implications. Clinical Cancer Research, 14(12), 3881-3888.
DOI Scopus168 WoS152 Europe PMC140
2008 Foot, N., Dalton, H., Shearwin-Whyatt, L., Dorstyn, L., Tan, S., Yang, B., & Kumar, S. (2008). Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. Blood, 112(10), 4268-4275.
DOI Scopus127 WoS119 Europe PMC118
2008 Cao, X., Lill, N., Boase, N., Shi, P., Croucher, D., Shan, H., . . . Yang, B. (2008). Nedd4 controls animal growth by regulating IGF-1 signaling. Science Signaling, 1(38), 1-10.
DOI Scopus145 WoS139 Europe PMC136
2008 Putz, U., Howitt, J., Lackovic, J., Foot, N., Kumar, S., Silke, J., & Tan, S. (2008). Nedd4 Family-interacting Protein 1 (Ndfip1) Is Required for the Exosomal Secretion of Nedd4 Family Proteins. Journal of Biological Chemistry, 283(47), 32621-32627.
DOI Scopus146 WoS138 Europe PMC130
2008 He, Y., Hryciw, D., Carroll, M., Myers, S., Whitbread, A., Kumar, S., . . . Hooper, J. (2008). The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels. Journal of Biological Chemistry, 283(35), 24000-24010.
DOI Scopus29 WoS30 Europe PMC28
2008 Cakouros, D., Mills, K., Denton, D., Paterson, A., Daish, T., & Kumar, S. (2008). dLKR/SDH regulates hormone-mediated histone arginine methylation and transcription of cell death genes. Journal of Cell Biology, 182(3), 481-495.
DOI Scopus26 WoS25 Europe PMC21
2008 Denton, D., Mills, K., & Kumar, S. (2008). Methods and protocols for studying cell death in Drosophila. Methods in Enzymology, 446, 17-37.
DOI Scopus32 WoS31 Europe PMC27
2008 Schuetz, F., Kumar, S., Poronnik, P., & Adams, D. (2008). Regulation of the voltage-gated K⁺ channels KCNQ2/3 and KCNQ3/5 by serum- and glucocorticoid-regulated kinase-1. American Journal of Physiology-Cell Physiology, 295(1), C73-C80.
DOI Scopus25 WoS24 Europe PMC24
2008 Manning, J., Colussi, P., Koblar, S., & Kumar, S. (2008). Nedd1 expression as a marker of dynamic centrosomal localization during mouse embryonic development. Histochemistry and Cell Biology, 129(6), 751-764.
DOI Scopus14 WoS15 Europe PMC14
2008 Dorstyn, L., & Kumar, S. (2008). A biochemical analysis of the activation of the Drosophila caspase DRONC. Cell Death and Differentiation, 15(3), 461-470.
DOI Scopus54 WoS48 Europe PMC43
2007 Dibbens, L., Ekberg, J., Taylor, I., Hodgson, B., Conroy, S., Lensink, I., . . . Poronnik, P. (2007). NEDD4-2 as a potential candidate susceptibility gene for epileptic photosensitivity. Genes, Brain and Behavior, 6(8), 750-755.
DOI Scopus48 WoS49 Europe PMC45
2007 Lee, I., Dinudom, A., Sanchez-Perez, A., Kumar, S., & Cook, D. (2007). Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2. Journal of Biological Chemistry, 282(41), 29866-29873.
DOI Scopus130 WoS124 Europe PMC119
2007 Doumanis, J., Dorstyn, L., & Kumar, S. (2007). Molecular determinants of the subcellular localization of the Drosophila Bcl-2 homologues DEBCL and BUFFY. Cell Death and Differentiation, 14(5), 907-915.
DOI Scopus27 WoS27 Europe PMC23
2007 Sanchez-Perez, A., Kumar, S., & Cook, D. (2007). GRK2 interacts with and phosphorylates Nedd4 and Nedd4-2. Biochemical and Biophysical Research Communications, 359(3), 611-615.
DOI Scopus28 WoS25 Europe PMC24
2007 Kumar, S. (2007). Caspases and their many biological functions. Cell Death and Differentiation, 14(1), 1-2.
DOI Scopus16 WoS14
2007 Manning, J., & Kumar, S. (2007). NEDD1: Function in microtubule nucleation spindle assembly and beyond. International Journal of Biochemistry & Cell Biology, 39(1), 7-11.
DOI Scopus26 WoS26 Europe PMC25
2007 Kumar, S. (2007). Caspase function in programmed cell death. Cell Death and Differentiation, 14(1), 32-43.
DOI Scopus735 WoS703 Europe PMC606
2007 Ekberg, J., Schuetz, F., Boase, N. A., Conroy, S. J., Manning, J., Kumar, S., . . . Adams, D. J. (2007). Regulation of the voltage-gated K+ channels KCNQ2/3 and KCNQ3/5 by ubiquitination: Novel role for Nedd4-2. Journal of Biological Chemistry, 282(16), 12135-12142.
DOI Scopus80 WoS79 Europe PMC73
2006 Dorstyn, L., & Kumar, S. (2006). A cytochrome c-free fly apoptosome. Cell Death and Differentiation, 13(7), 1049-1051.
DOI Scopus27 WoS24 Europe PMC22
2006 Sang, Q., Kim, M., Kumar, S., Bye, N., Morganti-Kossmann, M., Gunnersen, J., . . . Tan, S. (2006). Nedd4-WW domain-binding protein 5 (Ndfip1) is associated with neuronal survival after acute cortical brain injury. Journal of Neuroscience, 26(27), 7234-7244.
DOI Scopus50 WoS49 Europe PMC44
2006 Shearwin-Whyatt, L., Dalton, H., Foot, N., & Kumar, S. (2006). Regulation of functional diversity within the Nedd4 family by accessory and adaptor proteins. Bioessays, 28(6), 617-628.
DOI Scopus142 WoS136 Europe PMC123
2006 Rauh, R., Dinudom, A., Fotia, A., Paulides, M., Kumar, S., Korbmacher, C., & Cook, D. (2006). Stimulation of the epithelial sodium channel (ENaC) by the serum- and glucocorticoid-inducible kinase (Sgk) involves the PY motifs of the channel but is independent of sodium feedback inhibition. Pflugers Archiv-European Journal of Physiology, 452(3), 290-299.
DOI Scopus32 WoS29 Europe PMC25
2006 Fotia, A., Cook, D., & Kumar, S. (2006). The ubiquitin-protein ligases Nedd4 and Nedd4-2 show similar ubiquitin-conjugating enzyme specificities. International Journal of Biochemistry & Cell Biology, 38(3), 472-479.
DOI Scopus25 WoS25 Europe PMC24
2006 Mills, K., Daish, T., Harvey, K., Pfleger, C., Hariharan, I., & Kumar, S. (2006). The Drosophila melanogaster Apaf-1 homologue ARK is required for most, but not all, programmed cell death. Journal of Cell Biology, 172(6), 809-815.
DOI Scopus62 WoS60 Europe PMC62
2005 Korten, Z., Cakouros, D., & Kumar, S. (2005). Ecdysone-mediated up-regulation of the effector caspase DRICE is required for hormone-dependent apoptosis in Drosophila cells. Journal of Biological Chemistry, 280(12), 11981-11986.
DOI Scopus59 WoS52 Europe PMC48
2005 Mills, K., Daish, T., & Kumar, S. (2005). The function of the Drosophila caspase DRONC in cell death and development. Cell Cycle, 4(6), 744-746.
DOI Scopus14 WoS13 Europe PMC11
2005 Umadevi, N., Kumar, S., & Narayana, N. (2005). Crystallization and preliminary X-ray diffraction studies of the WW4 domain of the Nedd4-2 ubiquitin-protein ligase. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online, 61(PN Part 12), 1084-1086.
DOI Scopus5 WoS5 Europe PMC5
2004 Shearwin-Whyatt, L., Brown, D., Wylie, F., Stow, J., & Kumar, S. (2004). N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking. Journal of Cell Science, 117(16), 3679-3689.
DOI Scopus65 WoS64 Europe PMC58
2004 Kumar, S., & Cakouros, D. (2004). Transcriptional control of the core cell-death machinery. Trends in Biochemical Sciences, 29(4), 193-196.
DOI Scopus60 WoS60 Europe PMC53
2004 Hryciw, D., Ekberg, J., Lee, A., Lensink, I., Kumar, S., Guggino, W., . . . Poronnik, P. (2004). Nedd4-2 functionally interacts with CIC-5: Involvement in constitutive albumin endocytosis in proximal tubule cells. Journal of Biological Chemistry, 279(53), 54996-55007.
DOI Scopus81 WoS78 Europe PMC71
2004 Kumar, S. (2004). Migrate, differentiate, proliferate, or die: pleiotropic functions of an apical 'apoptotic caspase'. Signal Transduction Knowledge Environment (S T K E), 254(254), 1-4.
DOI Scopus21 Europe PMC11
2004 Daish, T., Mills, K., & Kumar, S. (2004). Drosophila caspase DRONC is required for specific developmental cell death pathways and stress-induced apoptosis. Developmental Cell, 7(6), 909-915.
DOI Scopus157 WoS150 Europe PMC139
2004 Chew, S., Akdemir, F., Chen, P., Lu, W., Mills, K., Daish, T., . . . Abrams, J. (2004). The apical caspase dronc governs programmed and unprogrammed cell death in Drosophila. Developmental Cell, 7(6), 897-907.
DOI Scopus137 WoS131 Europe PMC124
2004 Dorstyn, L., Mills, K., Lazebnik, Y., & Kumar, S. (2004). The two cytochrome c species, DC3 and DC4, are not required for caspase activation and apoptosis in Drosophila cells. Journal of Cell Biology, 167(3), 405-410.
DOI Scopus110 WoS105 Europe PMC98
2004 Baliga, B., Read, S., & Kumar, S. (2004). The biochemical mechanism of caspase-2 activation. Cell Death and Differentiation, 11(11), 1234-1241.
DOI Scopus179 WoS164 Europe PMC151
2004 Murdaca, J., Treins, C., Monthouel-Kartmann, M., Pontier-Brest, R., Kumar, S., Van Obberghen, E., & Giorgetti-Peraldi, S. (2004). Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation. Journal of Biological Chemistry, 279(25), 26754-26761.
DOI Scopus116 WoS115 Europe PMC103
2004 Ekert, P., Read, S., Silke, J., Marsden, V., Kaufmann, H., Hawkins, C., . . . Vaux, D. (2004). Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die. Journal of Cell Biology, 165(6), 835-842.
DOI Scopus161 WoS151 Europe PMC135
2004 Fotia, A., Ekberg, J., Adams, D., Cook, D., Poronnik, P., & Kumar, S. (2004). Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2. Journal of Biological Chemistry, 279(28), 28930-28935.
DOI Scopus138 WoS135 Europe PMC130
2004 Dinudom, A., Fotia, A., Lefkowitz, R., Young, J., Kumar, S., & Cook, D. (2004). The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na+ channels. Proceedings of the National Academy of Sciences of the United States of America, 101(32), 11886-11890.
DOI Scopus76 WoS72 Europe PMC65
2004 Cakouros, D., Daish, T., & Kumar, S. (2004). Ecdysone receptor directly binds the promoter of the Drosophila caspase dronc, regulating its expression in specific tissues. Journal of Cell Biology, 165(5), 631-640.
DOI Scopus89 WoS88 Europe PMC74
2004 Cakouros, D., Daish, T., Mills, K., & Kumar, S. (2004). An arginine-histone methyltransferase, CARMER, coordinates ecdysone-mediated apoptosis in drosophila cells. Journal of Biological Chemistry, 279(18), 18467-18471.
DOI Scopus31 WoS31 Europe PMC30
2003 Baliga, B., & Kumar, S. (2003). Apaf-1/cytochrome c apoptosome: an essential initiator of caspase activation or just a sideshow?. Cell Death and Differentiation, 10(1), 16-18.
DOI Scopus98 WoS95 Europe PMC77
2003 Kim, T., Hung, C., Ling, M., Juang, J., He, L., Hardwick, J., . . . Wu, T. (2003). Enhancing DNA vaccine potency by coadministration of DNA encoding antiapoptotic proteins. Journal of Clinical Investigation, 112(1), 109-117.
DOI Scopus169 WoS156 Europe PMC131
2003 Quinn, L., Coombe, M., Mills, K., Daish, T., Colussi, P., Kumar, S., & Richardson, H. (2003). Buffy, a Drosophila Bcl-2 protein, has anti-apoptotic and cell cycle inhibitory functions. EMBO Journal, 22(14), 3568-3579.
DOI Scopus128 WoS117 Europe PMC110
2003 Daish, T., Cakouros, D., & Kumar, S. (2003). Distinct promoter regions regulate spatial and temporal expression of the Drosophila caspase dronc. Cell Death and Differentiation, 10(12), 1348-1356.
DOI Scopus32 WoS31 Europe PMC27
2003 Baliga, B., Colussi, P., Read, S., Dias, M., Jans, D., & Kumar, S. (2003). Role of prodomain in importin-mediated nuclear localization and activation of caspase-2. Journal of Biological Chemistry, 278(7), 4899-4905.
DOI Scopus93 WoS92 Europe PMC86
2002 Read, S., Baliga, B., Ekert, P., Vaux, D., & Kumar, S. (2002). A novel Apaf-1-independent putative caspase-2 activation complex. Journal of Cell Biology, 159(5), 739-745.
DOI Scopus151 WoS134 Europe PMC124
2002 Fotia, A., Dinudom, A., Shearwin, K., Koch, J. P., Korbmacher, C., Cook, D., & Kumar, S. (2002). The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels. FASEB Journal, 16(13), 70-91.
DOI Scopus92 WoS86 Europe PMC81
2002 Dorstyn, L., Read, S., Cakouros, D., Huh, J., Hay, B., & Kumar, S. (2002). The role of cytochrome c in caspase activation in Drosophila melanogaster cells. Journal of Cell Biology, 156(6), 1089-1098.
DOI Scopus173 WoS166 Europe PMC152
2002 Shcherbik, N., Kumar, S., & Haines, D. (2002). Substrate proteolysis is inhibited by dominant-negative Nedd4 and Rsp5 mutants harboring alterations in WW domain 1. Journal of Cell Science, 115(5), 1041-1048.
DOI Scopus18 WoS18 Europe PMC15
2002 Baliga, B., & Kumar, S. (2002). Role of BCL-2 family of proteins in malignancy. Hematological Oncology, 20(2), 63-74.
DOI Scopus87 WoS74 Europe PMC59
2002 Konstas, A., Shearwin-Whyatt, L., Fotia, A., Degger, B., Riccardi, D., Cook, D., . . . Kumar, S. (2002). Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein. Journal of Biological Chemistry, 277(33), 29406-29416.
DOI Scopus87 WoS85 Europe PMC79
2002 Harvey, K., Shearwin-Whyatt, L., Fotia, A., Parton, R., & Kumar, S. (2002). N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel golgi-associated protein. Journal of Biological Chemistry, 277(11), 9307-9317.
DOI Scopus108 WoS107 Europe PMC104
2002 Cakouros, D., Daish, T., Martin, D., Baehrecke, E., & Kumar, S. (2002). Ecdysone-induced expression of the caspase DRONC during hormone-dependent programmed cell death in Drosophila is regulated by Broad-Complex. Journal of Cell Biology, 157(6), 985-995.
DOI Scopus90 WoS87 Europe PMC76
2002 Richardson, H., & Kumar, S. (2002). Death to flies: Drosophila as a model system to study programmed cell death. Journal of Immunological Methods, 265(1-2), 21-38.
DOI Scopus92 WoS80 Europe PMC73
2002 O'Reilly, L., Ekert, P., Harvey, N., Marsden, V., Cullen, L., Vaux, D., . . . Kumar, S. (2002). Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9. Cell Death and Differentiation, 9(8), 832-841.
DOI Scopus169 WoS160 Europe PMC150
2002 Kumar, S., & Vaux, D. (2002). A Cinderella caspase takes center stage. Science, 297(5585), 1290-1291.
DOI Scopus102 WoS100 Europe PMC82
2001 Harvey, K., Dinudom, A., Cook, D., & Kumar, S. (2001). The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel. Journal of Biological Chemistry, 276(11), 8597-8601.
DOI Scopus141 WoS134 Europe PMC124
2001 Dinudom, A., Harvey, K., Komwatanat, P., Jolliffe, C., Young, J., Kumar, S., & Cook, D. (2001). Roles of the C termini of α-, β-, and γ-subunits of epithelial Na⁺ channels (ENaC) in regulating ENaC and mediating its inhibition by cytosolic Na⁺. Journal of Biological Chemistry, 276(17), 13744-13749.
DOI Scopus20 WoS20 Europe PMC18
2001 Shearwin-Whyatt, L., Baliga, B., Doumanis, J., & Kumar, S. (2001). Chimeric caspase molecules with potent cell killing activity in apoptosis-resistant cells. Biochemical and Biophysical Research Communications, 282(5), 1114-1119.
DOI Scopus5 WoS6 Europe PMC5
2001 Doumanis, J., Quinn, L., Richardson, H., & Kumar, S. (2001). STRICA, a novel Drosophila melanogaster caspase with an unusual serine/threonine-rich prodomain, interacts with DIAP1 and DIAP2. Cell Death and Differentiation, 8(4), 387-394.
DOI Scopus71 WoS67 Europe PMC60
2001 Harvey, N., Daish, T., Mills, K., Dorstyn, L., Quinn, L., Read, S., . . . Kumar, S. (2001). Characterization of the Drosophila caspase, DAMM. Journal of Biological Chemistry, 276(27), 25342-25350.
DOI Scopus76 WoS67 Europe PMC64
2000 Kumar, S. (2000). Cell death in the fly comes of age - Editorial. Cell Death and Differentiation, 7(11), 1021-1024.
2000 Quinn, L., Dorstyn, L., Mills, K., Colussi, P., Chen, P., Coombe, M., . . . Richardson, H. (2000). An essential role for the caspase dronc in developmentally programmed cell death in Drosophila. Journal of Biological Chemistry, 275(51), 40416-40424.
DOI Scopus137 WoS133 Europe PMC122
2000 Colussi, P., Quinn, L., Huang, D., Coombe, M., Read, S., Richardson, H., & Kumar, S. (2000). Debcl a proapoptotic Bcl-2 homologue is a component of the Drosophila melanogaster cell death machinery. Journal of Cell Biology, 148(4), 703-714.
DOI Scopus148 WoS137 Europe PMC126
2000 Jolliffe, C., Harvey, K., Haines, B., Parasivam, G., & Kumar, S. (2000). Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4. Biochemical Journal, 351(3), 557-565.
DOI Scopus97 WoS98 Europe PMC95
2000 Shearwin-Whyatt, L., Harvey, N., & Kumar, S. (2000). Subcellular localization and CARD-dependent oligomerization of the death adaptor RAIDD. Cell Death and Differentiation, 7(2), 155-165.
DOI Scopus51 WoS49 Europe PMC49
2000 Kumar, S., & Doumanis, J. (2000). The fly caspases. Cell Death and Differentiation, 7(11), 1039-1044.
DOI Scopus141 WoS129 Europe PMC116
2000 Kumar, S. (2000). Cell death in the fly comes of age. Cell Death and Differentiation, 7(11), 1021-1024.
DOI Scopus1 WoS1 Europe PMC1
1999 Kumar, S. (1999). Regulation of caspase activation in apoptosis: implications in pathogenesis and treatment of disease.. Clinical and experimental pharmacology & physiology, 26(4), 295-303.
DOI Europe PMC43
1999 Colussi, P. A., & Kumar, S. (1999). Targeted disruption of caspase genes in mice: What they tell us about the functions of individual caspases in apoptosis. Immunology and Cell Biology, 77(1), 58-63.
DOI Scopus48 WoS50 Europe PMC45
1999 Kumar, S. (1999). Regulation of Caspase Activation in Apoptosis: Implications in Pathogenesis and Treatment of Disease. Clinical and Experimental Pharmacology and Physiology, 26(-), 295-303.
DOI Scopus55 WoS55
1999 Kumar, S. (1999). Mechanisms mediating caspase activation in cell death. Cell Death and Differentiation, 6(-), 1060-1066.
DOI Scopus196 WoS186 Europe PMC153
1999 Dorstyn, L., Read, S., Quinn, L., Richardson, H., & Kumar, S. (1999). DECAY, a novel Drosophila caspase related to mammalian Caspase-3 and Caspase-7. Journal of Biological Chemistry, 274(43), 30778-30783.
DOI Scopus113 WoS107 Europe PMC95
1999 Harvey, K., & Kumar, S. (1999). Nedd4-like proteins: an emerging family of ubiquitin-protein ligases implicated in diverse cellular functions. Trends in Cell Biology, 9(5), 166-169.
DOI Scopus183 WoS186 Europe PMC171
1999 Kumar, S., & Colussi, P. (1999). Prodomains - adaptors - oligomerization: the pursuit of caspase activation in apoptosis. Trends in Biochemical Sciences, 24(36161), 1-Apr.
DOI Scopus92 WoS83 Europe PMC66
1999 Morrione, A., Plant, P., Valentinist, B., Staub, O., Kumar, S., Rotin, D., & Baserga, R. (1999). mGrb10 Interacts with Nedd4. Journal of Biological Chemistry, 274(34), 24094-24099.
DOI Scopus92 WoS91 Europe PMC79
1999 Harvey, K., Dinudom, A., Komwatanat, P., Jolliffe, C., Day, M., Parasivam, G., . . . Kumar, S. (1999). All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na⁺. Journal of Biological Chemistry, 274(18), 12525-12530.
DOI Scopus111 WoS110 Europe PMC100
1999 Shearwin-Whyatt, L., & Kumar, S. (1999). Caspases in developmental cell death. IUBMB Life, 48(2), 143-150.
DOI Scopus4 WoS4 Europe PMC2
1999 Dorstyn, L., Colussi, P., Quinn, L., Richardson, H., & Kumar, S. (1999). DRONC, an ecdysone-inducible Drosophila caspase. Proceedings of the National Academy of Sciences of the United States of America, 96(36251), 4307-4312.
DOI Scopus255 WoS249 Europe PMC216
1999 Ishibashi, H., Dinudom, A., Harvey, K., Kumar, S., Young, J., & Cook, D. (1999). Na+-H+ exchange in salivary secretory cells is controlled by an intracellular Na+ receptor. Proceedings of the National Academy of Sciences of the United States of America, 96(17), 9949-9953.
DOI Scopus29 WoS27 Europe PMC22
1998 Bird, C., Sutton, V., Sun, J., Hirst, C., Novak, A., Kumar, S., . . . Bird, P. (1998). Selective regulation of apoptosis: the cytoxic lymphocyte serpin, proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the FAS Cell death pathway. Molecular and Cellular Biology, 18(11), 6387-6398.
DOI Scopus266 WoS256 Europe PMC214
1998 Jans, D., Briggs, L., Jans, P., Froelich, C., Parasivam, G., Kumar, S., . . . Trapani, J. (1998). Nuclear targeting of the serine protease granzyme A (fragmentin-1). Journal of Cell Science, 111(17), 2645-2654.
DOI Scopus51 WoS45 Europe PMC38
1998 Colussi, P., Harvey, N., & Kumar, S. (1998). Prodomain-dependent neclear localisation of the caspase-2 (Nedd2) precursor: A novel fuction for a caspase prodomain. Journal of Biological Chemistry, 273(38), 24535-24542.
DOI Scopus144 WoS138 Europe PMC127
1998 Butt, A., Harvey, N., Parasivam, G., & Kumar, S. (1998). Dimerization and auto processing of the Nedd2 (caspase 2) precursor requires both the prodomain and the carboxyl-terminal regions. Journal of Biological Chemistry, 273(12), 6763-6768.
DOI Scopus100 WoS98 Europe PMC90
1998 Colussi, P., Harvey, N., Shearwin-Whyatt, L., & Kumar, S. (1998). Conversion of procaspase-3 to an autoactivating caspase by fusion to the caspase-2 predomain. Journal of Biological Chemistry, 273(41), 26566-26570.
DOI Scopus72 WoS70 Europe PMC59
1998 Harvey, K., Harvey, N., Michael, J., Parasivam, G., Waterhouse, N., Alnemri, E., . . . Kumar, S. (1998). Caspase-mediated cleavage of the ubiquitin-protein ligase Nedd4 during apoptosis. Journal of Biological Chemistry, 273(22), 13524-13530.
DOI Scopus65 WoS66 Europe PMC54
1998 Dinudom, A., Harvey, K., Komwatanat, P., Young, J., Kumar, S., & Cook, D. (1998). Nedd4 mediates control of an epithelial Na+ channel in salivary duct cells by cytosic Na+. Proceedings of the National Academy of Sciences of the United States of America, 95(12), 7169-7173.
DOI Scopus125 WoS128 Europe PMC110
1998 Kinoshita, A., Kinshita, M., Akiyama, H., Tomimoto, H., Akiguchi, I., Kumar, S., . . . Kimura, J. (1998). Identification of septins in neurofibrillary tangles in Alzheimers Disease. American Journal of Pathology, 153(5), 1551-1560.
DOI Scopus135 WoS129 Europe PMC119
1998 Waterhouse, N. J., Finucane, D. M., Green, D. R., Elce, J. S., Kumar, S., Alnemri, E. S., . . . Watters, D. J. (1998). Calpain activation is upstream of caspases in radiation-induced apoptosis. Cell Death and Differentiation, 5(12), 1051-1061.
DOI Scopus168 WoS161 Europe PMC132
1998 Harvey, N. L., & Kumar, S. (1998). The role of caspases in apoptosis.. Advances in Biochemical Engineering Biotechnology, 62, 107-128.
DOI Scopus48 Europe PMC30
1997 Kumar, S., Kinoshita, M., Dorstyn, L., & Noda, M. (1997). Origin, expression and possible functions of the two alternatively spliced forms of the mouse Nedd2 mRNA. Cell Death and Differentiation, 4(5), 378-387.
DOI Scopus28 WoS28
1997 Dorstyn, L., & Kumar, S. (1997). Differential inhibitory effects of CrmA, P35, IAP and three mammalian IAP homologues on apoptosis in NIH3T3 cells following various death stimuli. Cell Death and Differentiation, 4(7), 570-579.
DOI Scopus26 WoS26 Europe PMC22
1997 Kumar, S. (1997). The Bcl-2 family of proteins and activation of the ICE-CED-3 family of proteases: A balancing act in apoptosis?. Cell Death and Differentiation, 4(1), 2-3.
DOI Scopus21 WoS29 Europe PMC11
1997 Kinoshita, M., Kumar, S., Mizoguchi, A., Ide, C., Kinoshita, A., Haraguchi, T., . . . Noda, M. (1997). Nedd5, a mammalian septin, is a novel cytoskeletal component interacting with actin-based structures. Genes and Development, 11(12), 1535-1547.
DOI Scopus330 WoS325 Europe PMC292
1997 Kinoshita, M., Tomimoto, H., Kinoshita, A., Kumar, S., & Noda, M. (1997). Up-regulation of the Nedd2 gene encoding an ICE/Ced-3-like cysteine protease in the gerbil brain after transient global ischemia. Journal of Cerebral Blood Flow and Metabolism, 17(5), 507-514.
DOI Scopus65 WoS58 Europe PMC41
1997 Sun, J., Bottomley, S. P., Kumar, S., & Bird, P. I. (1997). Recombinant caspase-3 expressed in Pichia pastoris is fully activated and kinetically indistinguishable from the native enzyme. Biochemical and Biophysical Research Communications, 238(3), 920-924.
DOI Scopus31 WoS27 Europe PMC23
1997 Kumar, S., Harvey, K. F., Kinoshita, M., Copeland, N. G., Noda, M., & Jenkins, N. A. (1997). cDNA cloning, expression analysis, and mapping of the mouse Nedd4 gene. Genomics, 40(3), 435-443.
DOI Scopus136 WoS134 Europe PMC120
1997 Harvey, N. L., Butt, A. J., & Kumar, S. (1997). Functional activation of Nedd2/ICH-1 (caspase-2) is an early process in apoptosis. Journal of Biological Chemistry, 272(20), 13134-13139.
DOI Scopus122 WoS127 Europe PMC101
1997 Kumar, S. (1997). The apoptotic cysteine protease CPP32. International Journal of Biochemistry and Cell Biology, 29(3), 393-396.
DOI Scopus71 WoS59 Europe PMC56
1997 Iversen, P., Hercus, T., Zacharakis, B., Woodcock, J., Stomski, F., Kumar, S., . . . Lopez, A. (1997). The apoptosis-inducing granulocyte-macrophage colony-stimulating factor (GM-CSF) analog E21R functions through specific regions of the heterodimeric GM-CSF receptor, and requires interleukin-1 beta converting enzyme-like proteases.. Journal of Biological Chemistry, 272(15), 9877-9883.
DOI Scopus12 WoS12 Europe PMC9
1996 Waterhouse, N., Kumar, S., Song, Q., Strike, P., Sparrow, L., Dreyfuss, G., . . . Watters, D. (1996). Heteronuclear ribonucleoproteins C1 ad C2, components of the spliceosome, are specific targets of interleukin 1β-converting enzyme-like proteases in apoptosis. Journal of Biological Chemistry, 271(46), 29335-29341.
DOI Scopus115 WoS105 Europe PMC88
1996 Song, Q., Burrows, S., Smith, G., Lees-Miller, S., Kumar, S., Chan, D., . . . Lavin, M. (1996). Interleukin-1β-converting enzyme-like protease cleaves DNA-dependent protein kinase in cytotoxic T cell killing. Journal of Experimental Medicine, 184(2), 619-626.
DOI Scopus53 WoS51 Europe PMC41
1996 Kumar, S., & Lavin, M. F. (1996). The ICE family of cysteine proteases as effectors of cell death. Cell Death and Differentiation, 3(3), 255-267.
Scopus159 WoS160 Europe PMC85
1996 Harvey, N., Trapani, J., Fernandes-Alnemri, T., Litwack, G., Alnemri, E., & Kumar, S. (1996). Processing of the Nedd2 precursor by ICE-like proteases and granzyme B. Genes to Cells, 1(7), 673-686.
DOI Scopus54 WoS57 Europe PMC45
1996 Song, Q., Lees-Miller, S., Kumar, S., Zhang, N., Chan, D., Smith, G., . . . Lavin, M. (1996). DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis. EMBO Journal, 15(13), 3238-3246.
DOI Scopus332 WoS313 Europe PMC244
1996 Wallers, P., Waterhouse, N., Kumar, S., Sparrow, L., Strike, P., & Lavin, M. (1996). Specific cleavage of hnRNP C proteins in apoptosis. Biochemical Society Transactions, 24(4), 565.
1995 Kumar, S. (1995). Inhibition of apoptosis by the expression of antisense Nedd2. FEBS Letters, 368(1), 69-72.
DOI Scopus54 WoS56 Europe PMC43
1995 Kumar, S., & Harvey, N. (1995). Role of multiple cellular proteases in the execution of programmed cell death. FEBS Letters, 375(3), 169-173.
DOI Scopus150 WoS149 Europe PMC99
1995 Takai, S., Yoshida, Y., Noda, M., Yamada, K., & Kumar, S. (1995). Assignment of the developmentally regulated gene NEDD1 to human chromosome 12922 by fluorescence in situ hybridisation. Human Genetics, 95(1), 96-98.
DOI Scopus5 WoS6 Europe PMC4
1995 Kumar, S., White, D., Takai, S., Turczynowicz, S., Juttner, C., & Hughes, T. (1995). Apoptosis regulatory gene NEDD2 maps to human chromosome segment 7934-35, a region frequently affected in haematological neoplasms. Human Genetics, 95(6), 641-644.
DOI Scopus41 WoS39 Europe PMC26
1995 Kumar, S. (1995). ICE-like proteases in apoptosis. Trends in Biochemical Sciences, 20(5), 198-202.
DOI Scopus371 WoS368 Europe PMC225
1994 Kumar, S., Matsuzaki, T., Yoshida, Y., & Noda, M. (1994). Molecular cloning and biological activity of a novel developmentally regulated gene encoding a protein with β-transducin-like structure. Journal of Biological Chemistry, 269(15), 11318-11326.
DOI Scopus28 WoS29 Europe PMC30
1994 Kumar, S., Kinoshita, M., Noda, M., Copeland, N. G., & Jenkins, N. A. (1994). Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1β-converting enzyme. Genes and Development, 8(14), 1613-1626.
DOI Scopus614 WoS613 Europe PMC466
1993 Gatei, M. H., Naif, H. M., Kumar, S., Boyle, D. B., Daniel, R. C. W., Good, M. F., & Lavin, M. F. (1993). Protection of sheep against bovine leukemia virus (BLV) infection by vaccination with recombinant vaccinia viruses expressing BLV envelope glycoproteins: Correlation of protection with CD4 T-cell response to gp51 peptide 51-70. Journal of Virology, 67(4), 1803-1810.
DOI Scopus45 WoS40 Europe PMC29
1993 Kumar, S., Iwao, M., Yamagishi, T., Noda, M., & Asashima, M. (1993). Expression of GTP-binding protein gene drg during Xenopus laevis development. International Journal of Developmental Biology, 37(4), 539-546.
Scopus24 WoS25 Europe PMC18
1993 Kumar, S., Yoshida, Y., & Noda, M. (1993). Cloning of a cDNA Which Encodes a Novel Ubiquitin-like Protein. Biochemical and Biophysical Research Communications, 195(1), 393-399.
DOI Scopus135 WoS127 Europe PMC115
1992 Sazuka, T., Tomooka, Y., Kathju, S., Ikawa, Y., Noda, M., & Kumar, S. (1992). Identification of a developmentally regulated gene in the mouse central nervous system which encodes a novel proline rich protein. Bba Gene Structure and Expression, 1132(3), 240-248.
DOI Scopus11 WoS9 Europe PMC7
1992 Kumar, S., Tomooka, Y., & Noda, M. (1992). Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochemical and Biophysical Research Communications, 185(3), 1155-1161.
DOI Scopus494 WoS483 Europe PMC417
1992 Sazuka, T., Kinoshita, M., Tomooka, Y., Ikawa, Y., Noda, M., & Kumar, S. (1992). Expression of DRG during murine embryonic development. Biochemical and Biophysical Research Communications, 189(1), 371-377.
DOI Scopus35 WoS39 Europe PMC32
1992 Sazuka, T., Tomooka, Y., Ikawa, Y., Noda, M., & Kumar, S. (1992). DRG: A novel developmentally regulated GTP-binding protein. Biochemical and Biophysical Research Communications, 189(1), 363-370.
DOI Scopus52 WoS59 Europe PMC44
1990 Kumar, S., & Boyle, D. B. (1990). Mapping of a major early/late gene of fowlpox virus. Virus Research, 15(2), 175-185.
DOI Scopus12 WoS12 Europe PMC8
1990 Kumar, S., & Boyle, D. B. (1990). Activity of a fowlpox virus late gene promoter in vaccinia and fowlpox virus recombinants. Archives of Virology, 112(3-4), 139-148.
DOI Scopus12 WoS11 Europe PMC8
1990 Prideaux, C. T., Kumar, S., & Boyle, D. B. (1990). Comparative analysis of vaccinia virus promoter activity in fowlpox and vaccinia virus recombinants. Virus Research, 16(1), 43-57.
DOI Scopus19 WoS18 Europe PMC14
1990 Kumar, S., Andrew, M. E., Boyle, D. B., Brandon, R. B., Lavin, M. F., & Daniel, R. C. W. (1990). Expression of bovine leukaemia virus envelope gene by recombinant vaccinia viruses. Virus Research, 17(2), 131-142.
DOI Scopus14 WoS11 Europe PMC7
1990 Kumar, S., & Boyle, D. B. (1990). A poxvirus bidirectional promoter element with early/late and late functions. Virology, 179(1), 151-158.
DOI Scopus28 WoS25 Europe PMC20
1990 Coulston, J., Naif, H., Brandon, R., Kumar, S., Khan, S., Daniel, R. C. W., & Lavin, M. F. (1990). Molecular cloning and sequencing of an Australian isolate of proviral bovine leukaemia virus DNA: Comparison with other isolates. Journal of General Virology, 71(8), 1737-1746.
DOI Scopus87 Europe PMC66
1989 Baxter, G. D., Collins, R. J., Harmon, B. V., Kumar, S., Prentice, R. L., Smith, P. J., & Lavin, M. F. (1989). Cell death by apoptosis in acute leukaemia. Journal of Pathology, 158(2), 123-129.
DOI Scopus71 Europe PMC42
1989 Kumar, S., Seymour, G. J., & Lavin, M. F. (1989). Immunoglobulin synthesis and gene rearrangement in ataxia-telangiectasia B-lymphoblastoid cell lines. International Archives of Allergy and Applied Immunology, 89(2-3), 264-268.
DOI Scopus1
1989 Baxter, G. D., Kumar, S., & Lavin, M. F. (1989). T cell receptor rearrangement and expression in ataxia-telangiectasia B lymphoblastoid cells. Immunology and Cell Biology, 67(1), 57-62.
DOI Scopus3 Europe PMC2
1988 Kumar, S., Degnan, B. M., Ross, I. L., Hawkins, C. J., & Lavin, M. F. (1988). Isolation of DNA and RNA from ascidians. Marine Biology, 98(1), 95-100.
DOI Scopus11
1988 Kumar, S., Degnan, B. M., & Lavin, M. F. (1988). Cloning of a Major Repeat DNA Sequence from Pyura stolonifera. DNA, 7(6), 433-439.
DOI Scopus5 Europe PMC4
1987 Kumar, S., Baxter, G. D., Smith, P. J., Pemble, L., Collins, R. J., Prentice, R. L., & Lavin, M. F. (1987). DNA fragmentation in childhood T-cell acute lymphoblastic leukaemia.. Molecular Biology Medicine, 4(2), 111-121.
Scopus11 Europe PMC9
1987 Mohamed, R., Singh, S. P., Kumar, S., & Lavin, M. F. (1987). A defect in DNA topoisomerase II activity in ataxia-telangiectasia cells. Biochemical and Biophysical Research Communications, 149(1), 233-238.
DOI Scopus18 WoS22 Europe PMC15
1987 Lavin, M. F., Houldsworth, J., Kumar, S., Stein, J. L., & Stein, G. S. (1987). Coupling of histone mRNA levels to radioresistant DNA synthesis in ataxia-telangiectasia cells. Molecular and Cellular Biochemistry, 73(1), 45-54.
DOI Scopus7 WoS9 Europe PMC5
1986 Kumar, S., Lavin, M. F., Smith, P. J., Pemble, L., Collins, R. J., & Prentice, R. L. (1986). Rearrangements of t-cell receptor β-chain genes in human leukaemias. Molecular Immunology, 23(12), 1349-1356.
DOI Scopus2 WoS2 Europe PMC3
1986 Houldsworth, J., Kumar, S., & Lavin, M. F. (1986). Study of chromatin structure in ataxia-telangiectasia cells. Molecular Biology Reports, 11(3), 143-147.
DOI Scopus2 Europe PMC4
1985 Lavin, M., Houldsworth, J., Mohamed, R., Bates, P., & Kumar, S. (1985). Ataxia-telangiectasia: a human genetic disorder with predisposition to cancer.. Progress in Clinical and Biological Research, 172 A, 409-416.
Scopus1
1984 Kumar, S., & Nicholas, D. J. D. (1984). Na+ and K+ transport in Nitrosomonas europaea and Nitrobacter agilis. Bba Bioenergetics, 765(3), 268-274.
DOI Scopus1 WoS4
1984 Kumar, S., & Nicholas, D. J. D. (1984). Purification, properties and regulation of glutamine synthetase from Nitrobacter agilis. Journal of General Microbiology, 130(4), 959-966.
DOI Scopus4
1984 Kumar, S., & Nicholas, D. J. D. (1984). NAD+- and NADP+-dependent glutamate dehydrogenases in Nitrobacter agilis. Journal of General Microbiology, 130(4), 967-973.
DOI Scopus10
1984 KUMAR, S., & NICHOLAS, D. J. D. (1984). PURIFICATION, PROPERTIES AND REGULATION OF GLUTAMINE-SYNTHETASE FROM NITROBACTER-AGILIS. JOURNAL OF GENERAL MICROBIOLOGY, 130(APR), 959-966.
WoS9
1983 Kumar, S., & Nicholas, D. J. D. (1983). Proton electrochemical gradients in washed cells of Nitrosomonas europaea and Nitrobacter agilis. Journal of Bacteriology, 154(1), 65-71.
DOI Scopus20 WoS24 Europe PMC13
1983 Kumar, S., Nicholas, D. J. D., & Williams, E. H. (1983). Definitive 15N NMR evidence that water serves as a source of 'O' during nitrite oxidation by Nitrobacter agilis. FEBS Letters, 152(1), 71-74.
DOI Scopus100 WoS99 Europe PMC39
1982 Hollocher, T. C., Kumar, S., & Nicholas, D. J. D. (1982). Respiration-dependent proton translocation in Nitrosomonas europaea and its apparent absence in Nitrobacter agilis during inorganic oxidations. Journal of Bacteriology, 149(3), 1013-1020.
DOI Scopus37 WoS37 Europe PMC20
1982 Kumar, S., & Nicholas, D. J. D. (1982). Assimilation of inorganic nitrogen compounds by Nitrobacter agilis. Journal of General Microbiology, 128(8), 1795-1801.
DOI Scopus5
1982 Kumar, S., & Nicholas, D. J. D. (1982). A protonmotive force-dependent adenosine-5′ triphosphate synthesis in spheroplasts of Nitrosomonas europaea. FEMS Microbiology Letters, 14(1), 21-25.
DOI Scopus9 WoS9
1981 Kumar, S., & Nicholas, D. J. D. (1981). Oxygen-dependent nitrite uptake and nitrate production by cells, spheroplasts and membrane vesicles of Nitrobacter agilis. FEMS Microbiology Letters, 11(2-3), 201-206.
DOI Scopus4 WoS12
1981 Kumar, S., & Nicholas, D. (1981). Use of a thiocyanate-sensitive electrode for the determination of membrane potential in Azotobacter vinelandii. Biochemistry International, 3(6), 581-586.
Scopus3

Year Citation
2026 Sinha, D., Shah, S. S., & Kumar, S. (2026). Monitoring inflammasome activation by analysing ASC specks and oligomerisation. In Methods in Cell Biology. Elsevier.
DOI
2023 Puccini, J., & Kumar, S. (2023). The Caspase family of proteases. In R. Bradshaw, G. Hart, & P. Stahl (Eds.), Source details - Title: Encyclopedia of Cell Biology (Vol. 5, 2nd ed., pp. 165-177). UK: Academic Press.
DOI Scopus2
2021 Foot, N. J., & Kumar, S. (2021). The Role of Extracellular Vesicles in Sperm Function and Male Fertility. In S. Mathivanan, P. Fonseka, C. Nedeva, & I. Atukorala (Eds.), New Frontiers: Extracellular Vesicles (Vol. 97, pp. 483-500). Switzerland: Springer International Publishing.
DOI Scopus32 Europe PMC26
2018 Henshall, T., & Kumar, S. (2018). NEDD4-2. In S. Choi (Ed.), Source details - Title: Encyclopedia of signaling molecules (2 ed., pp. 3401-3406). Cham, Switzerland: Springer, Cham.
DOI
2018 Manning, J., & Kumar, S. (2018). NEDD4. In S. Choi (Ed.), Source details - Title: Encyclopedia of Signaling Molecules (2 ed., pp. 3395-3400). Singapore: Springer.
DOI
2018 Foot, N., & Kumar, S. (2018). NDFIP1 and NDFIP2. In S. Choi (Ed.), Source details - Title: Encyclopedia of signaling molecules (2 ed., pp. 3390-3395). Singapore: Springer.
DOI
2016 Puccini, J., & Kumar, S. (2016). Caspases. In R. A. Bradshaw, & P. D. Stahl (Eds.), Encyclopedia of Cell Biology (Vol. 3, pp. 364-373). Elsevier.
DOI Scopus5
2014 Dorstyn, L., & Kumar, S. (2014). Caspase-2 protocols. In P. Bozhkov, & G. Salvasen (Eds.), Caspases, paracaspases and metacaspases: methods and protocols (Vol. 1133, pp. 71-87). Humana Press.
DOI Scopus6 Europe PMC7
2013 Dorstyn, L., & Kumar, S. (2013). Insect Caspases. In N. Rawlings, & G. Salvesen (Eds.), Handbook of Proteolytic Enzymes, Volume 2 (Vol. 2, 3 ed., pp. 2286-2295). United Kingdom: Elsevier.
DOI Scopus1
2007 Daish, T. J., & Kumar, S. (2007). The biology of caspases. In Apoptosis Cell Signaling and Human Diseases (Vol. 2, pp. 347-362). Humana Press.
DOI
2005 Dorstyn, L., & Kumar, S. (2005). Programmed cell death in drosophila melanogaster. In When Cells Die II A Comprehensive Evaluation of Apoptosis and Programmed Cell Death (pp. 79-97). Wiley.
DOI Scopus1
2004 Kumar, S. (2004). Measurement of caspase activity in cells undergoing apoptosis. In H. Brady (Ed.), Methods in Molecular Biology - Volume 282 - Apoptosis methods and protocols (Vol. 282, pp. 19-30). 999 Riverview Drive, Suite 208, Totowa, New jersey 07512, USA: Humana Press.
DOI Scopus16 Europe PMC13
2003 Kumar, S., & Cakouros, D. (2003). The role of caspases in apoptosis. In S. Grimm (Ed.), Genetics of apoptosis (pp. 31-45). 9 Newtec Place, Magdalen Road, Oxford OX4 1RE, UK: Bios Scientific Publishers Ltd.
1999 Butt, A., & Kumar, S. (1999). Caspases: the molecular effectors of apoptosis. In Signalling pathways in apoptosis, 1999 (pp. 249-264). Harwood Academic Publishers.
1998 Dorstyn, L. E., Kumar, S., & Kinoshita, M. (1998). Caspases in Cell Death. In S. Kumar (Ed.), Apoptosis: Mechanisms and Role in Disease (Vol. 24, pp. 1-24). Springer New York.
DOI Scopus12 Europe PMC4
- Kumar, S. (n.d.). Measurement of Caspase Activity in Cells Undergoing Apoptosis. In Apoptosis Methods and Protocols (pp. 019-030). Humana Press.
DOI

Year Citation
2025 Thyagarajan, N., Le Leu, R., Kumar, S., Jesudason, S., & Manning, J. (2025). Increased Urinary Extracellular Vesicles And Reduced Expression of NEDD4L in Diabetic Nephropathy-A Pilot Study. In NEPHROLOGY Vol. 30 (pp. 1 page). WILEY.
2024 Shah, M., Hung, K., Baranwal, A., Price, Z., Al-Kali, A., Toop, C., . . . Hiwase, D. (2024). The 66th ASH Annual Meeting Abstract Abstracts. In BLOOD Vol. 144 (pp. 3214). ELSEVIER.
2023 Shah, M. V., Kutyna, M., Shah, S., Tran, E. N. H., Baranwal, A., Ladon, D., . . . Hiwase, D. (2023). Comparison of World Health Organization and International Consensus Classification Guidelines for Myeloid Neoplasms Harboring TP53-Mutations Using an Independent International Cohort. In BLOOD Vol. 142 (pp. 4 pages). CA, San Diego: ELSEVIER.
DOI WoS4
2022 Kok, C. H., Tran, E. N. H., Ladon, D., Chhetri, R., Baranwal, A., Sharplin, K. M., . . . Hiwase, D. (2022). Personalized Prediction Model to Risk Stratify Patients with Therapy-Related Myeloid Neoplasms. In BLOOD Vol. 140 (pp. 6962-6963). LA, New Orleans: ELSEVIER.
DOI
2022 Kumar, S., Lim, Y., & Dorstyn, L. (2022). Tumor and aneuploidy suppression by caspase-2. In CANCER SCIENCE Vol. 113 (pp. 1 page). WILEY.
2020 Dagdeviren, S., Shah, A., Okawa, M., Melnik, V., Sarikhani, M., Foot, N., . . . Lee, R. (2020). Arrdc4 Regulates Insulin-Stimulated Glucose Metabolism. In FASEB JOURNAL Vol. 34 (pp. 2 pages). San Diego, CA: WILEY.
DOI WoS1
2016 Yip, K. H., Kolesnikoff, N., Hauschild, N., Lopez, A. F., Galli, S. J., Kumar, S., & Grimbaldeston, M. A. (2016). The Nedd4-2-Ndfip1 axis is essential to curtail mast cell-dependent IgE-mediated anaphylaxis <i>in vivo</i>. In EUROPEAN JOURNAL OF IMMUNOLOGY Vol. 46 (pp. 16-17). Melbourne, AUSTRALIA: WILEY-BLACKWELL.
2009 Dinudom, A., Lee, I. -H., Campbell, C. R., Song, S. -H., Day, M. L., Kumar, S., & Cook, D. I. (2009). EPITHELIAL Na<SUP>+</SUP> CHANNELS ARE REGULATED BY CAVEOLIN-1. In JOURNAL OF PHYSIOLOGICAL SCIENCES Vol. 59 (pp. 431). SPRINGER TOKYO.
2009 Hiwase, D. K., White, D. L., Powell, J. A., Saunders, V. A., Zrim, S., Frede, A., . . . Hughes, T. (2009). Blocking of Cytokine Survival Signals along with Intense Bcr-Abl Kinase Inhibition May Eradicate CML Progenitor Cells. In BLOOD Vol. 114 (pp. 1258-1259). New Orleans, LA: AMER SOC HEMATOLOGY.
2008 Hiwase, D. K., White, D. L., Saunders, V. A., Melo, J. V., Kumar, S., & Hughes, T. P. (2008). Short-Term Intense Bcr-Abl Kinase Inhibition Is Adequate to Trigger Cell Death in CML Cell Lines but Not in CML-CD34+Cells Unless They Are Growth Factor Deprived. In BLOOD Vol. 112 (pp. 397). San Francisco, CA: AMER SOC HEMATOLOGY.
2002 Cook, D. I., Dinudom, A., Komwatana, P., Kumar, S., & Young, J. A. (2002). Patch-clamp studies on epithelial sodium channels in salivary duct cells. In Cell Biochemistry and Biophysics Vol. 36 (pp. 105-113). COOLANGATTA, AUSTRALIA: HUMANA PRESS INC.
DOI Scopus24 WoS22 Europe PMC21

Year Citation
2025 Windley, S., Neirijnck, Y., Vidovic, D., Schwarz, Q., Kumar, S., Nef, S., & Wilhelm, D. (2025). NEDD4 promotes Sertoli cell proliferation and adult Leydig cell differentiation in the murine testis.
DOI
2023 Dawar, S., Benitez, M. C., Lim, Y., Dite, T. A., Yousef, J. M., Thio, N., . . . Clemons, N. J. (2023). Caspase-2 protects against ferroptotic cell death.
DOI
2020 Lim, Y., De Bellis, D., Sandow, J., Capalbo, L., D’Avino, P. P., Murphy, J., . . . Kumar, S. (2020). Phosphorylation by Aurora B kinase regulates caspase-2 activity and function.
DOI Europe PMC1

  • New mechanisms regulating the biogenesis of extracellular vesicles, ARC - Discovery Projects, 01/01/2024 - 31/12/2026

  • Regulation of autophagy dependent cell and tissue deletion, ARC - Discovery Projects, 01/01/2021 - 31/03/2024

  • Ubiquitination-regulated sodium homeostasis in kidney disease, NHMRC - Project Grant, 01/01/2019 - 31/12/2021

  • Regulation of cell death, cell survival and ubiquitination in normal physiology and disease, NHMRC - Research Fellowship, 01/01/2016 - 31/12/2021

  • Deciphering the mechanisms of caspase-2-mediated suppression of aneuploidy and tumourigenesis, NHMRC - Project Grant, 01/01/2019 - 31/12/2021

  • Using mouse models to decipher the function of caspase-2 in limiting aneuploidy tolerance and cancer, NHMRC - Project Grant, 01/01/2018 - 30/06/2021

  • Cell death by self-eating: understanding autophagy-dependent tissue removal, ARC - Discovery Projects, 13/01/2017 - 12/01/2020

  • Hormone dependent autophagy and growth signalling in developmental cell death, NHMRC - Project Grant, 01/01/2017 - 31/12/2019

  • Exploring the role of Arrcd4 in extracellular vesicle biogenesis and its implications in tissue homeostasis , NHMRC - Project Grant, 01/01/2017 - 31/12/2019

  • Nedd4-2: a new player in polycystic kidney disease, NHMRC - Project Grant, 01/01/2016 - 31/12/2018

  • Cancer Discovery Accelerator, Australian Cancer Research Foundation, 01/06/2016 - 31/07/2018

  • Post-translational control of cell fate decision, ARC - Discovery Projects, 01/01/2015 - 31/12/2017

  • Deciphering the function of capcase-2 in DNA damage response and tumour suppression, NHMRC - Project Grant, 01/01/2014 - 31/12/2017

  • Cancer Discovery Accelerator, Cancer Council SA - Beat Cancer, 08/06/2016 - 08/06/2017

Date Role Research Topic Program Degree Type Student Load Student Name
2025 Principal Supervisor New mechanisms regulating extracellular vesicle biogenesis Doctor of Philosophy Doctorate Full Time Miss Tong Li
2025 Co-Supervisor Exploring the mechanisms of age-related polyploidy in inflammation and liver cancer - Doctorate Full Time Mr Manish Kumar Vuriti
2022 Principal Supervisor Regulation of autophagy in cell and tissue homeostasis Doctor of Philosophy Doctorate Full Time Ruchi Umargamwala
2022 Principal Supervisor Modulation of NEDD4-2 expression and activity as a cellular mechanism for ameliorating kidney disease Doctor of Philosophy Doctorate Part Time Miss Diva Sinha
2021 Principal Supervisor Identification and characterisation of NEDD4-2 regulated proteins in the renal tubular epithelia. - Doctorate Full Time Mrs Meriam Shabbar
2021 Principal Supervisor Deciphering the Role of New Adaptors in Regulation of Nedd4 Ubiquitin Ligases Doctor of Philosophy Doctorate Full Time Mr Ryan Daniel Norton

Date Role Research Topic Program Degree Type Student Load Student Name
2012 - 2016 Principal Supervisor Characterisation of Pathophysiological Function of NEDD4-2 in Kidney Doctor of Philosophy Doctorate Full Time Mr Pranay Goel
2010 - 2014 Principal Supervisor Characterisation of Caspase-2 Function in the DNA Damage Response and Tumour Suppression Doctor of Philosophy Doctorate Full Time Mr Joey Puccini
2007 - 2011 Co-Supervisor Defining the role of myeloid cells in the regulation of developmental, tumour and inflammation-stimulated lymphangiogenesis Doctor of Philosophy Doctorate Full Time Ms Emma Gordon
2006 - 2009 Principal Supervisor Analysis of the Function and Regulation of the Centrosomal Protein NEDD1 During Cell Division and Development Doctor of Philosophy Doctorate Full Time Jantina Anna Manning
2006 - 2010 Co-Supervisor Evaluation of Anti-proliferative and Pro-apoptotic Effects of Tyrosine Kinase Inhibitors on CML-CD34+ Cells Doctor of Philosophy Doctorate Full Time APrf Devendra Hiwase
2001 - 2005 Principal Supervisor Regulation of sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2 Doctor of Philosophy Doctorate Full Time Mr Andrew Fotia
2001 - 2005 Principal Supervisor An analysis of DRONC function and its regulation of expression during Drosophila development Doctor of Philosophy Doctorate Full Time Dr Tasman Daish
2000 - 2004 Principal Supervisor Characterisation of a Novel Caspase STRICA and the Bcl-2 Homologues BUFFY and DEBCL in Drosophila melanogaster Doctor of Philosophy Doctorate Full Time Miss Joanna Doumanis

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