Sarah Kiley

Dr Sarah Kiley

Research Fellow

Centre for Cancer Biology

College of Health

Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.


Dr. Sarah Boyle leads the Cancer Matrix and Mechanics Group within the Tumour Microenvironment Laboratory at the Centre for Cancer Biology.
A current ARC DECRA Research Fellow, Sarah's interdisciplinary research program focusses on understanding how mechanical stresses and inputs, the extracellular matrix, and mechanotransduction signalling contribute to cancer growth, metastasis, and the generation of a pro-tumourigenic microenvironment in breast and other solid cancers.

Date Position Institution name
2026 - ongoing Research Fellow Adelaide University
2021 - 2025 Research Fellow University of South Australia
2016 - 2020 Research Associate University of South Australia
2015 - 2016 Research Officer University of South Australia
2010 - 2011 Research Assistant University of Adelaide

Date Type Title Institution Name Country Amount
2025 Award South Australian Young Tall Poppy Award Australian Institute of Policy and Science Australia -
2024 Award Rob Sutherland Award Runner-up 8th International PacRim Breast and Prostate Cancer Meeting Australia -
2024 Award 2024 40 Under 40 Award Solstice Media, InDaily and CityMag Australia -
2023 Award Distinguished Alumni James McWha Rising Star Award University of Adelaide Australia -
2020 Award ANZSCDB Early Career Researcher Award 2020 Australia and New Zealand Society for Cell and Developmental Biology Australia -
2020 Award National Association of Research Fellows Postdoctoral Investigator Award 2020 Centre for Cancer Biology Australia -
2019 Research Award Hospital Research Foundation Travel Grant University of South Australia Australia -
2018 Award Centre for Cancer Biology Early Career Investigator Award Centre for Cancer Biology Australia -
2018 Research Award CASS Foundation Early Career Researcher Travel Award University of South Australia Australia -
2016 Award Australian Society for Medical Research Ross Wishart Memorial Award Australian Society for Medical Research Australia -
2016 Research Award Cancer Council Beat Cancer Project Travel Grant University of South Australia Australia -
2014 Research Award Cancer Council Beat Cancer Project Travel Grant University of Adelaide Australia -

Language Competency
English Can read, write, speak, understand spoken and peer review

Date Institution name Country Title
University of Adelaide Australia Doctor of Philosophy
University of Adelaide Australia Honours Degree of Bachelor of Science
University of Adelaide Australia Degree of Bachelor of Science (Biotechnology)

Year Citation
2024 Pittar, A., Buckley, E. J., Boyle, S. T., Ibbetson, S. J., & Samuel, M. S. (2024). Enhanced RHO-ROCK signaling is associated with CRELD2 production and fibroblast recruitment in cutaneous squamous cell carcinoma. Cytoskeleton, 81(12), 864-871.
DOI Scopus3 WoS3 Europe PMC4
2023 Orang, A., Dredge, B. K., Liu, C. Y., Bracken, J. M., Chen, C. -H., Sourdin, L., . . . Bracken, C. P. (2023). Basonuclin-2 regulates extracellular matrix production and degradation. Life Science Alliance, 6(10), e202301984-1-e202301984-17.
DOI Scopus5 WoS5 Europe PMC10
2023 Boyle, S. T. (2023). RISING STARS: Hormonal regulation of the breast cancer microenvironment. Journal of molecular endocrinology, 70(3, article no. e220174), 1-16.
DOI Scopus7 WoS8 Europe PMC7
2022 Law, A. M. K., Chen, J., Colino-Sanguino, Y., Fuente, L. R. D. L., Fang, G., Grimes, S. M., . . . Gallego-Ortega, D. (2022). ALTEN: A High-Fidelity Primary Tissue-Engineering Platform to Assess Cellular Responses Ex Vivo. Advanced Science, 9(21), 2103332-1-2103332-19.
DOI Scopus6 WoS6 Europe PMC10
2022 Le Cerf, B. A., Pyne, N., Kular, J., Boyle, S. T., Beattie, D. A., Krasowska, M., & Samuel, M. S. (2022). Nano-mechanical analyses of native and cross-linked collagen I matrices reveal the mechanical complexity of homogenous samples. Frontiers in Physics, 10(835038), 1-11.
DOI Scopus2 WoS2
2021 Poltavets, V., Esmaeili, Z., Boyle, S., Ramshaw, H., Lopez, A., Kochetkova, M., & Samuel, M. (2021). 14-3-3ζ-depletion impairs mammary gland development in the mouse.
DOI
2020 Boyle, S. T., Poltavets, V., Kular, J., Pyne, N. T., Sandow, J. J., Lewis, A. C., . . . Samuel, M. S. (2020). ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism. Nature Cell Biology, 22(7), 882-895.
DOI Scopus60 WoS60 Europe PMC57
2020 Whyte, C. E., Osman, M., Kara, E. E., Abbott, C., Foeng, J., McKenzie, D. R., . . . McColl, S. R. (2020). ACKR4 restrains antitumor immunity by regulating CCL21. Journal of Experimental Medicine, 217(6), 1-S4.
DOI Scopus30 WoS29 Europe PMC31
2020 Boyle, S. T., Poltavets, V., Kular, J., Pyne, N. T., Sandow, J. J., Lewis, A. C., . . . Samuel, M. S. (2020). Publisher Correction: ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism.. Nat Cell Biol, 22(7), 908.
DOI Scopus5 WoS4 Europe PMC6
2020 Boyle, S. T., Mittal, P., Kaur, G., Hoffmann, P., Samuel, M. S., & Klingler-Hoffmann, M. (2020). Uncovering tumor−stroma inter-relationships using MALDI Mass spectrometry imaging. Journal of Proteome Research, 19(10), 4093-4103.
DOI Scopus16 WoS16 Europe PMC14
2020 Boyle, S. T., Johan, M. Z., & Samuel, M. S. (2020). Tumour-directed microenvironment remodelling at a glance. Journal of Cell Science, 133(24), jcs247783-1-jcs247783-9.
DOI Scopus15 WoS14 Europe PMC8
2018 Boyle, S. T., Kular, J., Nobis, M., Ruszkiewicz, A., Timpson, P., & Samuel, M. S. (2018). Acute compressive stress activates RHO/ROCK-mediated cellular processes. Small GTPases, 11(5), 1-17.
DOI Scopus46 Europe PMC43
2017 Boyle, S., Gieniec, K., Gregor, C., Faulkner, J., McColl, S., & Kochetkova, M. (2017). Interplay between CCR7 and Notch1 axes promotes stemness in MMTV-PyMT mammary cancer cells. Molecular Cancer, 16(1), 19-1-19-8.
DOI Scopus26 WoS27 Europe PMC22
2016 Boyle, S., Ingman, W., Poltavets, V., Faulkner, J., Whitfield, R., McColl, S., & Kochetkova, M. (2016). The chemokine receptor CCR7 promotes mammary tumorigenesis through amplification of stem-like cells. Oncogene, 35(1), 105-115.
DOI Scopus33 WoS33 Europe PMC32
2016 Boyle, S. T., & Samuel, M. S. (2016). Mechano-reciprocity is maintained between physiological boundaries by tuning signal flux through the Rho-associated protein kinase. Small GTPases, 7(3), 139-146.
DOI Scopus28 Europe PMC24
2016 Samuel, M., Rath, N., Masre, S., Boyle, S., Greenhalgh, D., Kochetkova, M., . . . Olson, M. (2016). Tissue-selective expression of a conditionally-active ROCK2-estrogen receptor fusion protein. Genesis, 54(12), 636-646.
DOI Scopus10 WoS9 Europe PMC9
2015 Boyle, S., Faulkner, J., McColl, S., & Kochetkova, M. (2015). The chemokine receptor CCR6 facilitates the onset of mammary neoplasia in the MMTV-PyMT mouse model via recruitment of tumor-promoting macrophages. Molecular Cancer, 14(1), 115-1-115-14.
DOI Scopus52 WoS51 Europe PMC54
2014 Boyle, S. T., & Kochetkova, M. (2014). Breast cancer stem cells and the immune system: promotion, evasion and therapy. Journal of Mammary Gland Biology and Neoplasia, 19(2), 203-211.
DOI Scopus29 WoS29 Europe PMC22
  • Defining the casual relationships between the tumour ECM and cancer outcomes, NHMRC - Ideas Grants, 01/01/2025 - 31/12/2028

Date Role Research Topic Program Degree Type Student Load Student Name
2025 Co-Supervisor Understanding how the Epigenetic Field Effect Exerted by Cancers upon their Microenvironment Promotes Tumour Progression Doctor of Philosophy Doctorate Full Time Moganalaxmi Reckdharajkumar
2025 Co-Supervisor Understanding how the Epigenetic Field Effect Exerted by Cancers upon their Microenvironment Promotes Tumour Progression Doctor of Philosophy Doctorate Full Time Ms Moganalaxmi Reckdharajkumar
2024 Co-Supervisor Investigating Extracellular Matrix in Cardiac Outflow Tract Development - Master Full Time Miss Jasmine Ella Hartmann
2022 Co-Supervisor Understanding how the epigenetic field effect exerted by cancers upon their microenvironment promotes tumour progression Doctor of Philosophy Doctorate Full Time Mr Edward Jack Buckley

Date Role Committee Institution Country
2025 - ongoing Secretary Australian Society for Mechanobiology Australian Society for Mechanobiology Australia
2025 - ongoing Council Female Fellows Adelaide University Australia
2023 - ongoing Council South Australian Breast Cancer Study Group South Australian Breast Cancer Study Group Australia
2023 - ongoing Representative National Association of Research Fellows National Association of Research Fellows Australia
2023 - 2024 Council Centre for Cancer Biology/SAiGENCI/SAHMRI Adelaide Cancer Research Seminar Series Committee Centre for Cancer Biology Australia
2022 - 2025 Representative Australian Society for Mechanobiology Australian Society for Mechanobiology Australia
2017 - 2018 Director Centre for Cancer Biology Departmental Seminar Series Coordinator Centre for Cancer Biology Australia
2017 - 2018 Representative Australia and New Zealand Society for Cell and Developmental Biology Australia and New Zealand Society for Cell and Developmental Biology Australia
2016 - ongoing Council Centre for Cancer Biology Consumer Advocacy Group Centre for Cancer Biology Australia

Date Role Membership Country
2022 - ongoing Member International Society for Mechanobiology Australia
2020 - ongoing Member Matrix Biology Society of Australia and New Zealand Australia
2020 - ongoing Member Australasian Metastasis Research Society Australia
2016 - ongoing Member Australian Society for Medical Research Australia

Date Role Editorial Board Name Institution Country
2021 - ongoing Editor Frontiers Oncology- Breast Cancer Frontiers Australia

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