Chih-Tsung Yang

Dr Chih-Tsung Yang

Research Fellow: Nanofabrication

Centre for Cancer Biology

College of Health

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Dr. Chih-Tsung Yang is a THRF EMCR Fellow at the Future Industries Institute. His interdisciplinary research expertise is centred on the fields of biomaterials, biosensing, microfluidics and organ-on-a-chip models. His current research is focused on the development of bioengineered human organs-on-a-chip models to evaluate the therapeutic efficiency of nanomedicine and radiation therapy protocols.
Dr. Yang is currently leading an ambitious research program “Towards Precision Cancer Radiotherapy: Development of a Radiogenomic Tool through Patient-Derived Tumour on-Chips Reconstructing the Tumour Microenvironment”. His most recent work has been focused on the development of bioengineered tumour/tissue models aimed at providing new insight of the effect of ionizing radiation and, ultimately, at informing the design of better and safer radiotherapy algorithms. He initiated and coordinated the approval of the MOU between UniSA and Chang Gung University/Chang Gung Memorial Hospital (CGMH, Taiwan) in the field of proton beam therapy. He is also leading and coordinating several research projects with the proton beam therapy centre at CGMH.
Prior to the start of his PhD, he significantly contributed to the liquid biopsy technology that underpinned the successful spin-off of CellMax Life ($15 million from VCs). As an emerging leader in his field, he contributed directly to more than 30 publications in high-quality peer-reviewed journals, which is evidenced by the fact that 25 are published in Q1 journals in their field. Dr. Yang is actively engaged in his research community and is regularly invited to serve as a reviewer for peer-reviewed scientific journals (ACS Biomaterials Science & Engineering, ACS Applied Materials and Interfaces, Sensors, Optical Materials, Plos One and Applied Sciences). He is the UniSA node project leader of the signature project “Development of bioengineered multicellular systems” of the ARC Centre of Excellence for Convergent Bio-Nano Science &Technology (CBNS).

Development of microphysiological organ-on-chip towards precision radiotherapy.

● Linking response to radiation therapies with glioblastoma cell phenotype

● "Micropocket" for high-throughput preparation of tumouroids and screening of radiosensitisers

● Pumpless microfluidic perfusion device for long-term culture of brain tissue slices

● Development ofglioblastoma radiotherapy prognosis radiogenomic model

● 3D printed microtissue cassette for quantification of proton relative biological effectiveness

Year Citation
2026 Wang, X., Zhu, G., Lu, J., Hu, X., Zheng, W., Yang, K., . . . Ge, G. (2026). A Vascularized Lung Tumoroid-on-Chip Model for the Accurate Assessment of Anti-Invasion Agents. Advanced Functional Materials, 19 pages.
DOI Scopus1
2026 Lu, J., Huang, Y., Hu, S., Xuzhan, L., Huang, Y., Wu, B., . . . Ge, G. (2026). Modeling metastasis with tumor organoid-on-a-chip: from mechanistic study to anti-tumor drug discovery. Trac Trends in Analytical Chemistry, 199, 27 pages.
DOI
2025 Yang, K., Chu, X., Wang, X., Zhang, W., Lu, J., Xu, C., . . . Ge, G. (2025). Novel Vascularized Human Liver Organoids for Modeling Alcohol-Induced Liver Injury and Developing Hepatoprotective Therapy. Advanced Science, 13(9), e11169.
DOI Scopus3 WoS2 Europe PMC1
2025 Yang, C. T., Cho, I. C., Yu, C. F., Cheah, E., Liu, T., Lin, Y. P., . . . Thierry, B. (2025). 3D printed microtissue cassettes enabling high throughput proton radiobiological assays. Analytica Chimica Acta, 1356(344027), 1-7.
DOI
2025 Guan, B., Mills, S., Liu, T., Yang, C. T., & Priest, C. (2025). Integration of 3D-Printed Micro/Nanostructures with Interdigitated Electrodes for Low-Matrix-Effect Sensing. ACS Applied Materials and Interfaces, 17(26), 38678-38688.
DOI Scopus1 WoS1
2024 Shen, Y., Yang, C. T., Li, W., & Zhou, X. (2024). Single-virus-sensitive barcode qPCR mediated by the aggregation of gold nanoparticle probes. Analyst, 149(9), 2556-2560.
DOI Scopus1 WoS1
2024 Nguyen, C. T. V., Chow, S. K. K., Nguyen, H. N., Liu, T., Walls, A., Withey, S., . . . Huang, C. J. (2024). Formation of zwitterionic and self-healable hydrogels via amino-yne click chemistry for development of cellular scaffold and tumor spheroid phantom for MRI. ACS Applied Materials and Interfaces, 16(28), 36157-36167.
DOI Scopus10 WoS10 Europe PMC5
2024 Wang, X., Lu, J., Huang, Y., Liu, X., Fang, G., Yang, C. T., & Guo, Z. (2024). Editorial: Emerging bioanalytical techniques and therapies for human disease models. Frontiers in Bioengineering and Biotechnology, 12(1453813), 1-4.
DOI Scopus2 WoS2 Europe PMC1
2024 Yuan, J., Zhu, H., Li, S., Thierry, B., Yang, C. T., Zhang, C., & Zhou, X. (2024). Truncated M13 phage for smart detection of E. coli under dark field. Journal of Nanobiotechnology, 22(599), 1-16.
DOI Scopus7 WoS6 Europe PMC5
2023 Hou, J., Qian, X., Xu, Y., Guo, Z., Thierry, B., Yang, C. T., . . . Mao, C. (2023). Rapid and reliable ultrasensitive detection of pathogenic H9N2 viruses through virus-binding phage nanofibers decorated with gold nanoparticles. Biosensors and Bioelectronics, 237(115423), 1-8.
DOI Scopus24 WoS21 Europe PMC12
2023 Hou, J., Xu, Y., Sun, S., Zhong, X., Yang, C. T., & Zhou, X. (2023). Gold nanoparticles-decorated M13 phage SPR probe for dual detection of antigen biomarkers in serum. Sensors and Actuators B: Chemical, 374(132811), 1-8.
DOI Scopus29 WoS27
2023 Shen, Y., Wang, J., Li, Y., Yang, C. T., & Zhou, X. (2023). Modified bacteriophage for Tumor detection and targeted therapy. Nanomaterials, 13(4), 1-18.
DOI Scopus14 WoS13 Europe PMC12
2022 Guo, Z., Yang, C. T., Chien, C. C., Selth, L. A., Bagnaninchi, P. O., & Thierry, B. (2022). Optical Cellular Micromotion: A New Paradigm to Measure Tumor Cells Invasion within Gels Mimicking the 3D Tumor Environments. Small Methods, 6(8), 2200471-1-2200471-13.
DOI Scopus14 WoS14 Europe PMC10
2022 Qian, X., Shen, Y., Yuan, J., Yang, C. T., & Zhou, X. (2022). Visual and ultrasensitive detection of a Coronavirus using a Gold Nanorod Probe under dark field. Biosensors, 12(12, article no. 1146), 1-13.
DOI Scopus6 WoS6 Europe PMC4
2021 Jia, Z., Guo, Z., Yang, C. T., Prestidge, C., & Thierry, B. (2021). 'Mucus-on-chip': a new tool to study the dynamic penetration of nanoparticulate drug carriers into mucus. International Journal of Pharmaceutics, 598(120391), 1-9.
DOI Scopus32 WoS30 Europe PMC23
2021 Hou, J., Shen, J., Zhao, N., Yang, C. T., Thierry, B., Zhou, X., . . . Mao, C. (2021). Detection of a single circulating tumor cell using a genetically engineered antibody-like phage nanofiber probe. Materials Today Advances, 12(100168), 1-14.
DOI Scopus13 WoS14
2021 Xu, H., Shen, J., Yang, C. T., Thierry, B., Zhu, Y., Mao, C. B., & Zhou, X. (2021). Naked-eye counting of pathogenic viruses by phage-gold nanobiomaterials as probes. Materials Today Advances, 10(100122), 1-6.
DOI Scopus17 WoS16
2021 Ni, C., Shen, Y., Li, Z., Yang, C. T., Thierry, B., Yang, B., & Zhou, X. (2021). An ultrasensitive virus ELISA based on a magnetic mesoporous silica nanoprobe. Particle & Particle Systems Characterization, 38(11, article no. 2100146), 1-9.
DOI Scopus1 WoS1
2020 Delon, L. C., Guo, Z., Kashani, M. N., Yang, C. T., Prestidge, C., & Thierry, B. (2020). Hele Shaw microfluidic device: a new tool for systematic investigation into the effect of the fluid shear stress for organs-on-chips. MethodsX, 7(100980), 1-17.
DOI Scopus7 WoS7 Europe PMC3
2020 Chen, F., Di, T., Yang, C. T., Zhang, T., Thierry, B., & Zhou, X. (2020). Naked-eye enumeration of single chlamydia pneumoniae based on light scattering of gold nanoparticle probe. ACS Sensors, 5(4), 1140-1148.
DOI Scopus21 WoS21 Europe PMC14
2019 Zhou, X., Yang, C. T., Xu, Q., Lou, Z., Xu, Z., Thierry, B., & Gu, N. (2019). Gold nanoparticle probe-assisted antigen-counting chip using SEM. ACS applied materials and interfaces, 11(7), 6769-6776.
DOI Scopus16 WoS14 Europe PMC9
2019 Guo, Z., Yang, C. T., Maritz, M. F., Wu, H., Wilson, P., Warkiani, M. E., . . . Thierry, B. (2019). Validation of a Vasculogenesis Microfluidic Model for Radiobiological Studies of the Human Microvasculature. Advanced Materials Technologies, 4(4), 12 pages.
DOI Scopus37 WoS34
2019 Yang, C. T., Xu, Y., Pourhassan Moghaddam, M., Tran, D. P., Wu, L., & Zhou, X. (2019). Surface Plasmon Enhanced Light Scattering Biosensing: Size Dependence on the Gold Nanoparticle Tag. Sensors, 19(2, article no. 323), 1-12.
DOI Scopus25 WoS25 Europe PMC12
2019 Tran, D. P., Winter, M., Yang, C. T., Stockmann, R., Offenhausser, A., & Thierry, B. (2019). Silicon nanowires field effect transistors: a comparative sensing performance between electrical impedance and potentiometric measurement paradigms. Analytical chemistry, 91(19), 12568-12573.
DOI Scopus21 WoS21 Europe PMC9
2018 Chen, F., Tang, F., Yang, C. T., Zhao, X., Wang, J., Thierry, B., . . . Zhou, X. (2018). Fast and highly sensitive detection of pathogens wreathed with magnetic nanoparticles using dark-field microscopy. ACS Sensors, 3(10), 2175-2181.
DOI Scopus22 WoS22 Europe PMC15
2017 Pai, J. H., Yang, C. T., Hsu, H. Y., Wedding, A. B., & Thierry, B. (2017). Development of a simplified approach for the fabrication of localised surface plasmon resonance sensors based on gold nanorods functionalized using mixed polyethylene glycol layers. Analytica chimica acta, 974, 87-92.
DOI Scopus29 WoS25 Europe PMC14
2017 Yang, C. T., Pourhassan Moghaddam, M., Wu, L., Bai, P., & Thierry, B. (2017). Ultrasensitive detection of cancer prognostic miRNA biomarkers based on surface plasmon enhanced light scattering. ACS sensors, 2(5), 635-640.
DOI Scopus44 WoS41 Europe PMC27
2016 Chen, J. Y., Tsai, W. S., Shao, H. J., Wu, J. C., Lai, J. M., Lu, S. H., . . . Chang, Y. C. (2016). Sensitive and specific biomimetic lipid coated microfluidics to isolate viable circulating tumor cells and microemboli for cancer detection. Plos one, 11(3, article no. e0149633), 1-21.
DOI Scopus67 Europe PMC43
2016 Yang, C. T., Wu, L., Bai, P., & Thierry, B. (2016). Investigation of plasmonic signal enhancement based on long range surface plasmon resonance with gold nanoparticle tags. Journal of materials chemistry C, 4(41), 9897-9904.
DOI Scopus29 WoS30
2016 Tran, D. P., Winter, M. A., Wolfrum, B., Stockmann, R., Yang, C. T., Pourhassan Moghaddam, M., . . . Thierry, B. (2016). Toward intraoperative detection of disseminated tumor cells in lymph nodes with silicon nanowire field effect transistors. ACS Nano, 10(2), 2357-2364.
DOI Scopus59 WoS54 Europe PMC27
2016 Yang, C. T., Wu, L., Liu, X., Tran, N. T., Bai, P., Liedberg, B., . . . Thierry, B. (2016). Exploiting surface-plasmon-enhanced light scattering for the design of ultrasensitive biosensing modality. Analytical chemistry, 88(23), 11924-11930.
DOI Scopus27 WoS24 Europe PMC19
2015 Yang, C. T., Wang, Y., Frank, C. W., & Chang, Y. C. (2015). Chemoresponsive surface-tethered polypeptide brushes based on switchable secondary conformations. RSC advances, 5(105), 86113-86119.
DOI Scopus8
2014 Yang, C. T., Méjard, R., Griesser, H. J., Bagnaninchi, P. O., & Thierry, B. (2014). Cellular micromotion monitored by long-range surface plasmon resonance with optical fluctuation analysis. Analytical chemistry, 87(3), 1456-1461.
DOI Scopus54 WoS50 Europe PMC24
2014 Liu, T., Yang, C. T., Dieguez, L., Denman, J. A., & Thierry, B. (2014). Robust and flexible fabrication of chemical micropatterns for tumor spheroid preparation. ACS Applied Materials and Interfaces, 6(13), 10162-10171.
DOI Scopus11 WoS11 Europe PMC6
2010 Yang, C. T., Wang, Y., & Chang, Y. C. (2010). Effect of solvents and temperature on the conformation of poly(beta-benzyl-L-aspartate) brushes. Biomacromolecules, 11(5), 1308-1313.
DOI Scopus28 Europe PMC9
2009 Yang, C. T., Wang, Y., Yu, S., & Chang, Y. C. I. (2009). Controlled molecular organization of surface macromolecular assemblies based on stimuli-responsive polypeptide brushes. Biomacromolecules, 10(1), 58-65.
DOI Scopus26 Europe PMC10

Date Role Research Topic Program Degree Type Student Load Student Name
2023 Principal Supervisor New radiobiological insights using a microphysiological device enabling long-term culture of patient-derived brain tumour tissue slices and cerebral organoid slices  - Doctorate Full Time Tesi Liu
2023 Co-Supervisor Next generation bioengineered in vitro tumour models Doctor of Philosophy Doctorate Part Time Mr Luke Bredberg
2023 Co-Supervisor Next generation bioengineered in vitro tumour models - Doctorate Part Time Mr Luke Bredberg
2023 Principal Supervisor New radiobiological insights using a microphysiological device enabling long-term culture of patient-derived brain tumour tissue slices and cerebral organoid slices  - Doctorate Full Time Tesi Liu

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