Carly Whyte

Dr Carly Whyte

Research Fellow

Centre for Cancer Biology

College of Health

Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.

Carly Whyte is a Cancer Council SA Early Career Research Fellow with expertise in the cellular and molecular mechanisms underlying immune-mediated pathology. Her research focuses on understanding how our immune systems can recognise and respond to cancer, with a view towards developing new immunotherapies for patients with solid tumours, particularly in head and neck cancer.
 
Dr Whyte holds a PhD in Immunology from the University of Adelaide, during which she discovered a previously unknown regulator of immune cell migration into tumours called ACKR4. She was then appointed as a postdoctoral research scientist at the Babraham Institute, Cambridge, UK and a Research Associate at Fitzwilliam College, University of Cambridge. During this postdoctoral training with Prof. Adrian Liston, Dr Whyte elucidated signaling networks of the cytokine IL-2, discovering novel mechanisms of action for this protein and identifying new regulatory networks which explained some of the common side-effects of therapeutic use of IL-2.

Year Citation
2025 Wang, H., Tumes, D. J., Keam, S., Lim, J. W., Nguyen, Q. A., Vlahos, R., . . . Yip, K. H. (2025). βc receptor antagonism mitigates sarcoidosis granuloma formation by targeting inflammatory signals and aberrant lipid metabolism. Frontiers in Immunology, 16, 16 pages.
DOI
2024 Burton, O. T., Bricard, O., Tareen, S., Gergelits, V., Andrews, S., Biggins, L., . . . Liston, A. (2024). The tissue-resident regulatory T cell pool is shaped by transient multi-tissue migration and a conserved residency program. Immunity, 57(7), 1586-1602.e10.
DOI Scopus59 WoS54 Europe PMC52
2023 Roca, C. P., Burton, O., Neumann, J., Tareen, S., Whyte, C. E., Gergelits, V., . . . Liston, A. (2023). A cross entropy test allows quantitative statistical comparison of t-SNE and UMAP representations. Cell Reports Methods, 3(1, article no. 100390), 1-15.
DOI Scopus22 WoS21 Europe PMC28
2023 Whyte, C. E., Tumes, D. J., Liston, A., & Burton, O. T. (2023). Correction to: Do more with Less: Improving High Parameter Cytometry Through Overnight Staining (Current Protocols, (2022), 2, 11, 10.1002/cpz1.589). Current Protocols, 3(1), e678.
DOI Scopus1 WoS1 Europe PMC1
2022 Whyte, C. E., Tumes, D. J., Liston, A., & Burton, O. T. (2022). Do more with less: improving high parameter cytometry through overnight staining. Current Protocols, 2(11, article no. e589), 1-20.
DOI Scopus42 WoS38 Europe PMC42
2022 Yshii, L., Pasciuto, E., Bielefeld, P., Mascali, L., Whyte, C. E., & Liston, A. (2022). Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation. Nature Immunology, 23(6), 878-891.
DOI Scopus155 WoS154 Europe PMC151
2022 Whyte, C. E., Singh, K., Burton, O. T., Aloulou, M., & Liston, A. (2022). Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits. Journal of Experimental Medicine, 219(7, article no. e20212391), 1-30.
DOI Scopus38 WoS35 Europe PMC36
2022 Whyte, C. E., Singh, K., Burton, O. T., Aloulou, M., Kouser, L., Veiga, R. V., . . . Liston, A. (2022). Correction: Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits (Journal of Experimental Medicine (10.1084/jem.20212391)). Journal of Experimental Medicine, 219(8), e2021239107142022c.
DOI Scopus1
2021 Roca, C. P., Burton, O. T., Gergelits, V., Prezzemolo, T., Whyte, C. E., Halpert, R., . . . Liston, A. (2021). AutoSpill is a principled framework that simplifies the analysis of multichromatic flow cytometry data. Nature Communications, 12(1, article no. 2890), 1-16.
DOI Scopus37 WoS35 Europe PMC35
2021 Hill, D. L., Whyte, C. E., Innocentin, S., Lee, J. L., Dooley, J., Wang, J., . . . Linterman, M. A. (2021). Impaired HA-specific T follicular helper cell and antibody responses to influenza vaccination are linked to inflammation in humans. ELIFE, 10, 30 pages.
DOI WoS37
2021 Hill, D. L., Whyte, C. E., Innocentin, S., Le Lee, J., Dooley, J., Wang, J., . . . Linterman, M. A. (2021). Impaired HA-specific T follicular helper cell and antibody responses to influenza vaccination are linked to inflammation in humans. eLife, 10(e70554), e70554-1-e70554-30.
DOI Scopus39 Europe PMC44
2020 Pasciuto, E., Burton, O. T., Roca, C. P., Lagou, V., Whyte, C. E., & Liston, A. (2020). Microglia require CD4 T cells to complete the fetal-to-adult transition. Cell, 182(3), 625-640.
DOI Scopus275 WoS265 Europe PMC284
2020 Whyte, C. E., Osman, M., Kara, E. E., Abbott, C., Foeng, J., McKenzie, D. R., . . . McColl, S. R. (2020). ACKR4 restrains antitumor immunity by regulating CCL21. Journal of Experimental Medicine, 217(6), 1-S4.
DOI Scopus31 WoS30 Europe PMC31
2020 Liston, A., & Whyte, C. E. (2020). Bile acids mediate signaling between microbiome and the immune system. Immunology and Cell Biology, 98(5), 349-350.
DOI Scopus11 WoS9 Europe PMC9
2020 Nasrallah, R., Imianowski, C. J., Bossini Castillo, L., Grant, F. M., Whyte, C. E., & Roychoudhuri, R. (2020). A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by T.reg cells. Nature, 583(7816), 447-452.
DOI Scopus42 WoS41 Europe PMC47
2019 Koay, H. -F., Su, S., Amann-Zalcenstein, D., Daley, S. R., Comerford, I., Miosge, L., . . . Godfrey, D. I. (2019). A divergent transcriptional landscape underpins the development and functional branching of MAIT cells. ScienceImmunology, 4(41), eaay6039-1-eaay6039-16.
DOI Scopus91 WoS89 Europe PMC101
2018 Kara, E. E., Bastow, C. R., McKenzie, D. R., Whyte, C. E., Fenix, K. A., Babb, R., . . . McColl, S. R. (2018). Atypical chemokine receptor 4 shapes activated B cell fate. Journal of Experimental Medicine, 215(3), 801-813.
DOI Scopus22 WoS22 Europe PMC24
2017 Boyle, S., Gieniec, K., Gregor, C., Faulkner, J., McColl, S., & Kochetkova, M. (2017). Interplay between CCR7 and Notch1 axes promotes stemness in MMTV-PyMT mammary cancer cells. Molecular Cancer, 16(1), 19-1-19-8.
DOI Scopus27 WoS28 Europe PMC22
2017 McKenzie, D., Kara, E., Bastow, C., Tyllis, T., Fenix, K., Gregor, C., . . . McColl, S. (2017). IL-17-producing γδ T cells switch migratory patterns between resting and activated states. Nature Communications, 8(15632), 15632-1-15632-13.
DOI Scopus106 WoS102 Europe PMC105
2015 Kara, E., McKenzie, D., Bastow, C., Gregor, C., Fenix, K., Ogunniyi, A., . . . McColl, S. (2015). CCR2 defines in vivo development and homing of IL-23-driven GM-CSF-producing Th17 cells. Nature Communications, 6(8644), 8644-1-8644-1 7.
DOI Scopus116 WoS113 Europe PMC105
2014 Harata-Lee, Y., Turvey, M., Brazzatti, J., Gregor, C., Brown, M., Smyth, M., . . . McColl, S. (2014). The atypical chemokine receptor CCX-CKR regulates metastasis of mammary carcinoma via an effect on EMT. Immunology and Cell Biology, 92(10), 815-824.
DOI Scopus17 WoS18 Europe PMC18
2014 Kara, E., Comerford, I., Fenix, K., Bastow, C., Gregor, C., McKenzie, D., & McColl, S. (2014). Tailored immune responses: novel effector helper T cell subsets in protective immunity. PLoS Pathogens, 10(2), 1003905-1-1003905-15.
DOI Scopus73 WoS65 Europe PMC61
2013 Comerford, I., Harata-Lee, Y., Bunting, M., Gregor, C., Kara, E., & McColl, S. (2013). A myriad of functions and complex regulation of the CCR7/CCL19/CCL21 chemokine axis in the adaptive immune system. Cytokine & Growth Factor Reviews, 24(3), 269-283.
DOI Scopus242 WoS238 Europe PMC235
2010 Comerford, I., Bunting, M., Fenix, K., Haylock-Jacobs, S., Litchfield, W., Harata-Lee, Y., . . . McColl, S. (2010). An immune paradox: how can the same chemokine axis regulate both immune tolerance and activation? CCR6/CCL20: a chemokine axis balancing immunological tolerance and inflammation in autoimmune disease. Bioessays, 32(12), 1067-1076.
DOI Scopus103 WoS101 Europe PMC93

Year Citation
2017 Gregor, C. E., Kara, E. E., Fenix, K. A., McKenzie, D. R., Comerford, I., & McColl, S. R. (2017). Effector T helper cell recruitment to inflammatory sites via CCR2. In SWISS MEDICAL WEEKLY Vol. 147 (pp. 64S). E M H SWISS MEDICAL PUBLISHERS LTD.

Year Citation
2020 Koay, H. F., Su, S., Amann-Zalcenstein, D., Daley, S. R., Comerford, I., Whyte, C. E., . . . Godfrey, D. (2020). A divergent transcriptional landscape underpins the development and functional branching of MAIT cells. Poster session presented at the meeting of JOURNAL OF IMMUNOLOGY. Honolulu, HI: AMER ASSOC IMMUNOLOGISTS.
2016 Foeng, J., Harata-Lee, Y., Gregor, C., Pederson, S., Brown, M., Symth, M., . . . McColl, S. (2016). The role of ACKR4 in melanoma biology and anti-tumour immunity. Poster session presented at the meeting of EUROPEAN JOURNAL OF IMMUNOLOGY. Melbourne, AUSTRALIA: WILEY-BLACKWELL.

Year Citation
2020 Whyte, C., Singh, K., Burton, O., Aloulou, M., Moudra, A., Roca, C., . . . Liston, A. (2020). Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits.
DOI Europe PMC2
2020 Roca, C., Burton, O., Prezzemolo, T., Whyte, C., Halpert, R., Kreft, Ł., . . . Liston, A. (2020). AutoSpill: A method for calculating spillover coefficients to compensate or unmix high-parameter flow cytometry data.
DOI Europe PMC2

  • Overcoming immune exhaustion in recurrent head and neck cancer, Garnett Passe & Rodney Williams Memorial Foundation-Conjoint Grant, 01/01/2025 - 31/12/2027

  • Defining the therapeutic potential of eosinophils in melanoma, Australian Melanoma Research Foundation, 01/02/2025 - 31/07/2026

Date Role Research Topic Program Degree Type Student Load Student Name
2025 Co-Supervisor Overcoming immune cell exhaustion in head and neck cancer Doctor of Philosophy Doctorate Full Time Kashaf Tariq

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