Skye has worked as a history researcher for Aboriginal Community organisations, an oral historian for the Indigenous Oral Health Unit at the University of Adelaide, and as an expert ethnohistorian for South Australian Native Title Services.

Her areas of specialisation include Australian colonial history, colonial cross-cultural relations, encounter history, environmental history, belonging and senses of place, legacies of historical injustice, grassroots reconciliation, Native Title research including apical ancestor identification.

Skye was awarded the University of Adelaide's School of Humanities Early Career Researcher Prize for 2020. Her article 'Recognising Country: tracing stories of wounded spaces in mid-northern South Australia' won the Australian Historical Association's inaugural Ann Curthoy's prize and was published in History Australia in 2020. Her first book Nharangga Wargunni Bugi-Buggillu: A journey through Narungga History (Wakefield Press, 2011) examines cross-cultural relations on nineteenth century Yorke Peninsula, South Australia. Her second book Memory, Place and Aboriginal‒Settler History (Anthem Press, 2017) is a place centred ethnography which investigates the absence of Aboriginal people in settler descendants’ historical consciousness.

Skye has taught courses on Australian history, colonial history and Aboriginal-settler history at the tertiary level. She currently convenes a comparative course titled 'Aboriginal people and the colonial world' which focusses on Australia, Canada and Aotearoa New Zealand.