Chandra Kirana
Adelaide Medical School
Faculty of Health and Medical Sciences
My Research :Dr Chandra Kirana's research interest focus on finding biomarkers for bowel cancer patients using proteomic approaches. Almost 90% of bowel cancer patients died from metastatic dissemination mostly to the liver. Protein biomarkers are urgently required to support current methodologies to improve accuracy in stratifying patients into low and high risk of metastasis so that accurate disease management will be given to the patients to increase survival. In addition, she is also interested in using the concept of "seed and soil" to understand the mechanism of metastatic dissemination of colorectal cancer to the liver. Her work equipped with a large number of samples from bowel cancer patients completed with clinical parameters of the patients and the histology of tumours. She also has experience in isolation and identification of bio-active compounds from medicinal plants using various chromatographic and spectrophotometric techniques. Her previous work involved using small animals to assess efficacy of active compounds isolated from medicinal plants including AOM-induced colon cancer and DSS-induced inflammatory bowel disease model study. Collaborations:Clinicians at The Queen Elizabeth Hospital and Royal Adelaide HospitalMr John Keating, Wellington Hospital, Wellington, New ZealandProfessor Richard Stubbs, P3 Research, Wellington, New ZealandDr Lifeng Peng, Centre for Biodiscovery, School of Biological Sciences, Victoria University of Wellington, Wellington, New ZealandDr Andrea Bubendorfer, Callaghan Innovation, New Zealand's Innovation Agency, Wellington, New ZealandConsumer Engagement:Cancer Voices SA
I have been working on Sjogren Disease in the last 5 years. Sjogren Disease (SjD), a systemic autoimmune rheumatic disease, characterized mainly by diminished function of the lacrimal, salivary glands and mucosal surfaces leading to dry eyes, dry mouth and dryness of other organs. The majority of patients with SjD manifested features of other organ inflammation including arthritis, interstitial lung disease, tubulointerstitial nephritis and lymphoma, which is life-threatening. Diagnosis of SjD is not very straight forward due to various symptoms. Early detection of SjD is very crucial to prevent severe organ manifestations. The pathogenesis of SjD remains unknown. The SjD projects aim to collect detailed medical information including serological data and biological samples of patients who diagnosed with SjD and met 2016 ACR-EULAR classification Criteria and consented for the study. Data and biobank samples of participants are collected at baseline and annual visit at Rheumatology Unit at TQEH, to further understand the pathogenesis of disease. Patient's impacted quality of life is also studied by participant's self reported using questionnaires incluing Compas 31, SF36, FACIT Fatique Scale, ESSPRI, AUA SS, OSDI, Epworth Sleepiness Scale.
| Date | Position | Institution name |
|---|---|---|
| 2018 - ongoing | Senior Research Officer | University of Adelaide |
| 2014 - 2018 | Research Officer | University of Adelaide, Adelaide |
| 2007 - 2018 | Postdoctoral Fellow | Wakefield Biomedical Research Institute |
| 2003 - 2006 | Postdoctoral Fellow | Diet & nutrition (CSIRO), Adelaide |
| 1989 - 1999 | Lecturer | Brawijaya University |
| Language | Competency |
|---|---|
| English | Can peer review |
| Indonesian | Can peer review |
| Date | Institution name | Country | Title |
|---|---|---|---|
| 1999 - 2003 | University of Adelaide, Adelaide | Australia | PhD |
| 1993 - 1996 | University of Adelaide, Adelaide | Australia | MAgSc |
| Gadjah Mada University | Indonesia | Bsc (Hons) (Biology) |
| Year | Citation |
|---|---|
| 2023 | Krishnan, S. T., Winkler, D., Creek, D., Anderson, D., Kirana, C., Maddern, G. J., . . . Voelcker, N. H. (2023). Staging of colorectal cancer using lipid biomarkers and machine learning.. Metabolomics, 19(10), 11 pages. Scopus13 WoS12 Europe PMC10 |
| 2020 | Kirana, C., Smith, E., Ngo, D. T., Trochsler, M. I., Hewett, P. J., Stubbs, R. S., . . . Hauben, E. (2020). High preoperative levels of circulating SFRP5 predict better prognosis in colorectal cancer patients.. Future Oncol, 16(31), 2499-2509. Scopus9 WoS9 Europe PMC8 |
| 2019 | Kirana, C., Peng, L., Miller, R., Keating, J. P., Glenn, C., Shi, H., . . . Stubbs, R. S. (2019). Combination of laser microdissection, 2D-DIGE and MALDI-TOF MS to identify protein biomarkers to predict colorectal cancer spread. Clinical Proteomics, 16(1), 13 pages. Scopus33 WoS29 Europe PMC21 |
| 2017 | Kirana, C., Ruszkiewicz, A., Stubbs, R., Hardingham, J., Hewett, P., Maddern, G., & Hauben, E. (2017). Soluble HLA-G is a differential prognostic marker in sequential colorectal cancer disease stages. International Journal of Cancer, 140(11), 2577-2586. Scopus32 WoS27 Europe PMC21 |
| 2017 | Miljkovic, D., Ou, J., Kirana, C., Hulse, K., Hauben, E., Psaltis, A., . . . Vreugde, S. (2017). Discordant frequencies of tissue-resident and circulating CD180-negative B cells in chronic rhinosinusitis. International Forum of Allergy and Rhinology, 7(6), 609-614. Scopus4 WoS4 Europe PMC2 |
| 2013 | Shi, H., Hayes, M., Kirana, C., Miller, R., Keating, J., & Stubbs, R. (2013). Overexpression of aminoacylase 1 is associated with colorectal cancer progression. Human Pathology, 44(6), 1089-1097. Scopus16 WoS16 Europe PMC17 |
| 2012 | Kirana, C., Shi, H., Laing, E., Hood, K., Miller, R., Bethwaite, P., . . . Stubbs, R. (2012). Cathepsin D expression in colorectal cancer: from proteomic discovery through validation using western blotting, immunohistochemistry, and tissue microarrays. International journal of proteomics, 2012, 1-11. Europe PMC20 |
| 2012 | Shi, H., Hayes, M., Kirana, C., Miller, R., Keating, J., MacArtney-Coxson, D., & Stubbs, R. (2012). TUFM is a potential new prognostic indicator for colorectal carcinoma. Pathology, 44(6), 506-512. Scopus30 WoS28 Europe PMC25 |
| 2009 | Kirana, C., Ward, T., Jordan, T. W., Rawson, P., Royds, J., Shi, H. J., . . . Hood, K. (2009). Compatibility of toluidine blue with laser microdissection and saturation labeling DIGE. Proteomics, 9(2), 485-490. Scopus13 WoS12 Europe PMC11 |
| 2007 | Kirana, C., Jones, G., Record, I., & McIntosh, G. (2007). Anticancer properties of panduratin A isolated from Boesenbergia pandurata (Zingiberaceae). Journal of Natural Medicines, 61(2), 131-137. Scopus68 WoS51 |
| 2005 | Kirana, C., Rogers, P. F., Bennett, L. E., Abeywardena, M. Y., & Patten, G. S. (2005). Naturally derived micelles for rapid in vitro screening of potential cholesterol-lowering bioactives. Journal of Agricultural and Food Chemistry, 53(11), 4623-4627. Scopus68 WoS54 Europe PMC36 |
| 2003 | Kirana, C., McIntosh, G., Record, I., & Jones, G. (2003). Antitumor activity of extract of Zingiber aromaticum and its bioactive sesquiterpenoid zerumbone. Nutrition and Cancer-An International Journal, 45(2), 218-225. Scopus116 WoS95 Europe PMC59 |
| 2003 | Kirana, C., Record, I., McIntosh, G., & Jones, G. (2003). Screening for antitumor activity of 11 species of Indonesian Zingiberaceae using human MCF-7 and HT-29 cancer cells. Pharmaceutical Biology, 41(4), 271-276. Scopus63 WoS45 |
| Year | Citation |
|---|---|
| 2019 | Sulaiman, R., Isnanto, B., Ki, H., & Kirana, C. (2019). Cryptography in (LSB) method using rc4 algorithm and aes algorithm in digital image to improve message security. In Proceedings - 2018 4th International Conference on Computing, Engineering, and Design, ICCED 2018 (pp. 29-34). online: IEEE. DOI Scopus2 |
| 2018 | Kirana, C. (2018). Communication between mothers and children about environmental issues (a study about the role of mothers to educate their children on keeping a clean environment). In E3S Web of Conferences Vol. 74 (pp. 1-7). online: EDP Sciences. DOI Scopus3 |
| 2005 | Kirana, C., Rogers, P. F., Bennett, L. E., Abeywardena, M. Y., & Patten, G. S. (2005). Rapid screening for potential cholesterol-lowering peptides using naturally derived micelle preparation. In Australian Journal of Dairy Technology Vol. 60 (pp. 163-166). AUSTRALIA, Adelaide: DAIRY INDUSTRY ASSOC AUSTRALIA. Scopus8 WoS7 |
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| Date | Role | Committee | Institution | Country |
|---|---|---|---|---|
| 2017 - ongoing | Member | TQEH Strategic Research Direction | The Queen Elizabeth Hospital - Basil Hetzel Research Institute | Australia |
| 2016 - ongoing | Member | The Institute (BHI) Policy Committee | Basil Hetzel Institute | Australia |
| 2015 - ongoing | Co-Chair | The Institute (Basil Hetzel Institute) Management Committee | Basil Hetzel Research Institute | Australia |
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