Dr Lorraine Mackenzie

Associate Research Professor

School of Pharmacy and Biomedical Science

College of Health

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


Year Citation
2025 Ionmhain, U. N., Chiew, A. L., Tierney, M., Al Ahmad, J., Pidcock, S., Whan, F. T., . . . Roberts, D. M. (2025). Loperamide-induced severe cardiotoxicity: a toxicokinetic and toxicodynamic analysis derived from a case series and the published literature. Clinical Toxicology, 63(4), 226-235.
DOI
2025 Shihana, F., Wijerathna, T. M., Gawarammana, I. B., Shahmy, S., Chathuranga, U., Palangasinghe, C., . . . Mohamed, F. (2025). Nephrotoxicity biomarkers following propanil (3,4-dichloropropionanilide) self-poisoning. Clinical Toxicology, 63(4), 236-245.
DOI
2025 Brighenti, M. D. S., Montanheri, L. R. D. S., Duque, M. D., Andreo Filho, N., Lopes, P. S., Garcia, M. T. J., . . . Leite Silva, V. R. (2025). In vitro drug release and ex vivo dermal drug permeation studies of selected commercial benzoyl peroxide topical formulations: correlation between human and porcine skin models. Molecular Pharmaceutics, 22(3), 1365-1372.
DOI WoS7 Europe PMC5
2025 Roberts, M. S., Zhang, Q., Mackenzie, L., & Medley, G. A. (2025). Quantitative structure permeability relationships for phenolic compounds applied to human epidermal membranes in various solvents. European Journal of Pharmaceutical Sciences, 204(106914), 1-13.
DOI
2024 Qiang, S., Mohamed, F., Raubenheimer, J., Buckley, N. A., Roberts, M. S., & Mackenzie, L. (2024). Clinical toxicology of acute glyphosate self-poisoning: impact of plasma concentrations of glyphosate, its metabolite and polyethoxylated tallow amine surfactants on the toxicity. Clinical Toxicology, 62(8), 483-496.
DOI WoS1 Europe PMC1
2024 Mangion, S. E., Mikkonen, A., Mackenzie, L., Roberts, M. S., & Maibach, H. I. (2024). Multiple topical product dermatitis: paradigms in understanding and future perspectives. JEADV Clinical Practice, 3(1), 49-64.
DOI WoS1
2024 Walsham, J., Hammond, N., Blumenthal, A., Cohen, J., Myburgh, J., Finfer, S., . . . Venkatesh, B. (2024). Fludrocortisone dose-response relationship in septic shock: a randomised phase II trial. Intensive Care Medicine, 50(12), 2050-2060.
DOI Scopus13 WoS13 Europe PMC9
2023 Mikkonen, A. T., Martin, J., Upton, R. N., Barker, A. O., Brumley, C. M., Taylor, M. P., . . . Roberts, M. S. (2023). Spatio-temporal trends in livestock exposure to per- and polyfluoroalkyl substances (PFAS) inform risk assessment and management measures. Environmental Research, 225(article no. 115518), 14 pages.
DOI Scopus21 WoS22 Europe PMC15
2023 Mikkonen, A. T., Martin, J., Upton, R. N., Moenning, J. L., Numata, J., Taylor, M. P., . . . Mackenzie, L. (2023). Dynamic exposure and body burden models for per- and polyfluoroalkyl substances (PFAS) enable management of food safety risks in cattle. Environment International, 180(108218), 12 pages.
DOI Scopus13 WoS12 Europe PMC8
2023 Mangion, S. E., Mackenzie, L., Roberts, M. S., & Holmes, A. M. (2023). Seborrheic dermatitis: topical therapeutics and formulation design. European Journal of Pharmaceutics and Biopharmaceutics, 185, 148-164.
DOI WoS16 Europe PMC14
2022 Qiang, S., Mohamed, F., Mackenzie, L., & Roberts, M. S. (2022). Rapid determination of polyethoxylated tallow amine surfactants in human plasma by LC-MSMS. Talanta, 254(124115), 1-12.
DOI WoS6 Europe PMC6
2022 Alinaghi, A., Zhang, Q., Williams, D. B., Mackenzie, L., & Roberts, M. S. (2022). Thermodynamic and kinetic analysis of human epidermal penetration of phenolic compounds: I. Stratum corneum solubility and partitioning. International Journal Of Pharmaceutics, 630(122424), 1-10.
DOI WoS3 Europe PMC2
2022 Rambabu, L., Mohamed, F., Dhanarisi, J., Gawarammana, I., Raubenheimer, J., Mackenzie, L., . . . Eddleston, M. (2022). Acute phenthoate self-poisoning: a prospective case series. Clinical Toxicology, 60(2), 214-220.
DOI WoS3 Europe PMC1
2021 Al Qurain, A. A., Gebremichael, L. G., Khan, M. S., Williams, D. B., Mackenzie, L., Phillips, C., . . . Wiese, M. D. (2021). Opioid prescribing and risk of drug-opioid interactions in older discharged patients with polypharmacy in Australia. International Journal of Clinical Pharmacy, 43(2), 365-374.
DOI Scopus9 WoS8 Europe PMC9
2021 Al Qurain, A. A., Upton, R., Williams, D. B., Mackenzie, L., Phillips, C., Russell, P. T., . . . Wiese, M. D. (2021). Population pharmacokinetic model of subcutaneous fentanyl in older acute care patients. European Journal Of Clinical Pharmacology, 77(9), 1357-1368.
DOI Scopus3 WoS4 Europe PMC4
2021 Gebremichael, L. G., Suppiah, V., Wiese, M. D., Mackenzie, L., Phillips, C., Williams, D. B., & Roberts, M. S. (2021). Efficacy and safety of statins in ethnic differences: a lesson for application in Indigenous Australian patient care. Pharmacogenomics, 22(9), 553-571.
DOI Scopus1
2021 Al Qurain, A. A., Williams, D. B., Mackenzie, L., Roberts, M. S., & Wiese, M. D. (2021). Simultaneous LC-MS/MS quantification of oxycodone, tramadol and fentanyl and their metabolites (noroxycodone, oxymorphone, O- desmethyltramadol, N- desmethyltramadol, and norfentanyl) in human plasma and whole blood collected via venepuncture and volumetric absorptive micro sampling. Journal of Pharmaceutical and Biomedical Analysis, 203(114171), 1-8.
DOI Scopus14 WoS11 Europe PMC10
2020 Al Qurain, A. A., Gebremichael, L. G., Khan, M. S., Williams, D. B., Mackenzie, L., Phillips, C., . . . Wiese, M. D. (2020). Prevalence and factors associated with analgesic prescribing in poly-medicated elderly patients. Drugs and Aging, 37(4), 291-300.
DOI Scopus22 WoS23 Europe PMC19
2020 Holmes, A. M., Mackenzie, L., & Roberts, M. S. (2020). Disposition and measured toxicity of zinc oxide nanoparticles and zinc ions against keratinocytes in cell culture and viable human epidermis. Nanotoxicology, 14(2), 263-274.
DOI WoS37 Europe PMC19
2014 Kelly, D., Mackenzie, L., & Saint, D. (2014). Mechanoelectric feedback does not contribute to the Frank-Starling relation in the rat and guinea pig heart. AIMS Biophysics, 1(1), 16-30.
DOI Scopus2 WoS2
2011 Nayyar, S., Mackenzie, L., Lau, D. H., Kelly, D., Brooks, A. G., Roberts-Thomson, K., & Sanders, P. (2011). Impact of irrigation flow rate on tissue temperature profile and lesion geometry in an ovine thigh muscle radio-frequency ablation model. EUROPEAN HEART JOURNAL, 32, 806.
2011 Lau, D., Psaltis, P., Mackenzie, L., Kelly, D., Carbone, A., Worthington, M., . . . Sanders, P. (2011). Atrial remodeling in an ovine model of anthracycline-induced nonischemic cardiomyopathy: remodeling of the same sort. Journal of Cardiovascular Electrophysiology, 22(2), 175-182.
DOI Scopus41 WoS38 Europe PMC31
2011 Lau, D., Psaltis, P., Carbone, A., Kelly, D., Mackenzie, L., Worthington, M., . . . Sanders, P. (2011). Atrial protective effects of n-3 polyunsaturated fatty acids: A long-term study in ovine chronic heart failure. Heart Rhythm, 8(4), 575-582.
DOI Scopus25 WoS22 Europe PMC20
2010 Lau, D., Mackenzie, L., Shipp, N., Kuklik, P., Dimitri, H., Lobb, B., . . . Sanders, P. (2010). Feasibility of high-density electrophysiological study using multiple-electrode array in isolated small animal atria. Clinical and Experimental Pharmacology and Physiology, 37(10), 1023-1027.
DOI Scopus5 WoS4 Europe PMC4
2010 Lau, D., Mackenzie, L., Kelly, D., Psaltis, P., Brooks, A., Worthington, M., . . . Sanders, P. (2010). Hypertension and atrial fibrillation: Evidence of progressive atrial remodeling with electrostructural correlate in a conscious chronically instrumented ovine model. Heart Rhythm, 7(9), 1282-1290.
DOI Scopus172 WoS151 Europe PMC148
2010 Lau, D., Mackenzie, L., Rajendram, A., Psaltis, P., Kelly, D., Spyropoulos, P., . . . Sanders, P. (2010). Characterization of cardiac remodeling in a large animal "one-kidney, one-clip" hypertensive model. Blood Pressure, 19(2), 119-125.
DOI Scopus18 WoS15 Europe PMC19
2010 Lau, D., Mackenzie, L., Kelly, D., Psaltis, P., Worthington, M., Rajendram, A., . . . Sanders, P. (2010). Short-term hypertension is associated with the development of atrial fibrillation substrate: A study in an ovine hypertensive model. Heart Rhythm, 7(3), 396-404.
DOI Scopus94 WoS89 Europe PMC85
2010 Mackenzie, L., Pope, K. J., & Willoughby, J. O. (2010). EEG spindles in the rat: Evidence for a synchronous network phenomenon. EPILEPSY RESEARCH, 89(2-3), 194-206.
DOI WoS3 Europe PMC1
2010 Rangnekar, G., Chakrabarty, A., Sanders, P., & Mackenzie, L. (2010). Atrial Structural Remodeling is Progressive Following Exposure to Nicotine: Implications for Atrial Fibrillation.. CIRCULATION, 122(21), 2 pages.
2009 Sanders, P., Jaïs, P., Young, G. D., Sacher, F., Rotter, M., Hocini, M., . . . Haïssaguerre, M. (2009). Atrial Mechanical Function after Atrial Fibrillation Ablation. Unknown Journal, 225-232.
DOI
2008 Lau, D. H., Mackenzie, L., Worthington, M., Rajendram, A., Kelly, D., Kuklik, P., . . . Sanders, P. (2008). Atrial remodelling due to short term hypertension. EUROPEAN HEART JOURNAL, 29, 287-288.
2008 Stiles, M., Brooks, A., Kuklik, P., John, B., Dimitri, H., Lau, D., . . . Sanders, P. (2008). High-density mapping of atrial fibrillation in humans: Relationship between high-frequency activation and electrogram fractionation. Journal of Cardiovascular Electrophysiology, 19(12), 1245-1253.
DOI Scopus66 WoS59 Europe PMC58
2008 Psaltis, P., Carbone, A., Nelson, A., Lau, D., Manavis, J., Finnie, J., . . . Worthley, S. (2008). An ovine model of toxic, nonischemic cardiomyopathy-assessment by cardiac magnetic resonance imaging. Journal of Cardiac Failure, 14(9), 785-795.
DOI Scopus25 WoS19 Europe PMC15
2008 John, B., Stiles, M., Kuklik, P., Chandy, S., Young, G., Mackenzie, L., . . . Sanders, P. (2008). Electrical remodelling of the left and right atria due to rheumatic mitral stenosis. European Heart Journal, 29(18), 2234-2243.
DOI Scopus145 WoS124 Europe PMC116
2008 Stiles, M., Brooks, A., John, B., Shashidar, M., Wilson, L., Kuklik, P., . . . Sanders, P. (2008). The effect of electrogram duration on quantification of complex fractionated atrial electrograms and dominant frequency. Journal of Cardiovascular Electrophysiology, 19(3), 252-258.
DOI Scopus64 WoS52 Europe PMC49
2007 Stiles, M., Sanders, P., Disney, P., Brooks, A., John, B., Lau, D., . . . Young, G. (2007). Differential effects of intravenous magnesium on atrioventricular node conduction in supraventricular tachycardia. American Journal of Cardiology, 100(8), 1249-1253.
DOI Scopus19 WoS17 Europe PMC12
2006 Olsson, T., Broberg, M., Pope, K., Wallace, A., Mackenzie, L., Blomstrand, F., . . . Willoughby, J. (2006). Cell swelling seizures and spreading depression: An impedance study. Neuroscience, 140(2), 505-515.
DOI Scopus53 Europe PMC40
2006 Kelly, D., Mackenzie, L., Hunter, P., Smaill, B., & Saint, D. (2006). Gene expression of stretch-activated channels and mechanoelectric feedback in the heart. Clinical and Experimental Pharmacology and Physiology, 33(7), 642-648.
DOI Scopus57 WoS58 Europe PMC55
2005 Willoughby, J., Mackenzie, L., Pope, K., Broberg, M., & Nilsson, M. (2005). Localised astroglial dysfunction disrupts high-frequency EEG rhythms. Journal of Neural Transmission, 112(2), 205-213.
DOI Scopus9 Europe PMC9
2005 Mackenzie, L., Pope, K., & Willoughby, J. (2005). Gamma rhythms are not integral to EEG spindle phenomena. Clinical Neurophysiology, 116(4), 861-870.
DOI
2004 Mackenzie, L., Pope, K., & Willoughby, J. (2004). Physiological and pathological spindling phenomena have similar regional EEG power distributions. Brain Research, 1008(1), 92-106.
DOI
2004 Fitzgibbon, S., Pope, K., Mackenzie, L., Clark, C., & Willoughby, J. (2004). Cognitive tasks augment gamma EEG power. Clinical Neurophysiology, 115(8), 1802-1809.
DOI Scopus185 WoS159 Europe PMC112
2004 Byrne, C., Cooper, M., Cowled, P., Johnstone, R., Mackenzie, L., Marshallsay, L., . . . Ward, A. (2004). The photodynamic therapy (PDT) anticancer activity of a range of porphyrin dimers and related compounds derived from hematoporphyrin. Australian Journal of Chemistry, 57(11), 1091-1102.
DOI Scopus9 WoS7
2003 Willoughby, J., Mackenzie, L., Broberg, M., Thoren, A., Medvedev, A., Sims, N., & Nilsson, M. (2003). Fluorocitrate-mediated astroglial dysfunction causes seizures. Journal of Neuroscience Research, 74(1), 160-166.
DOI Scopus60 Europe PMC53
2003 Willoughby, J., Fitzgibbon, S., Pope, K., Mackenzie, L., Medvedev, A., Clark, C., . . . Wilcox, R. (2003). Persistent abnormality detected in the non-ictal electroencephalogram in primary generalised epilepsy. Journal of Neurology Neurosurgery and Psychiatry, 74(1), 51-55.
DOI Scopus71 WoS67 Europe PMC67
2003 Willoughby, J., Fitzgibbon, S., Pope, K., Mackenzie, L., Davey, M., Wilcox, R., & Clark, C. (2003). Mental tasks induce gamma EEG with reduced responsiveness in primary generalized epilepsies. Epilepsia, 44(11), 1406-1412.
DOI Scopus16 WoS11 Europe PMC10
2002 Mackenzie, L., Medvedev, A., Hiscock, J., Pope, K., & Willoughby, J. (2002). Picrotoxin-induced generalised convulsive seizure in rat: changes in regional distribution and frequency of the power of electroencephalogram rhythms. Clinical Neurophysiology, 113(4), 586-596.
DOI
2001 Hiscock, J., Mackenzie, L., Medvedev, A., & Willoughby, J. (2001). Kainic acid and seizure-induced Fos in subtypes of cerebrocortical neurons. Journal of Neuroscience Research, 66(6), 1094-1100.
DOI
1987 Cowled, P. A., Mackenzie, L., & Forbes, I. J. (1987). Pharmacological Modulation of Photodynamic Therapy with Hematoporphyrin Derivative and Light. Cancer Research, 47(4), 971-974.
Scopus36 WoS37 Europe PMC25
1985 Cowled, P. A., Mackenzie, L., & Forbes, I. J. (1985). Potentiation of photodynamic therapy with haematoporphyrin derivatives by glucocorticoids. Cancer Letters, 29(1), 107-114.
DOI Scopus31 WoS31 Europe PMC21

Year Citation
2010 Mackenzie, L., Rangnekar, G., Chakrabarty, A., & Sanders, P. (2010). Atrial structural changes following nicotine exposure: implications for atrial fibrillation. In EUROPEAN HEART JOURNAL Vol. 31 (pp. 78). Stockholm, SWEDEN: OXFORD UNIV PRESS.
2010 Mackenzie, L., Lau, D. H., Kelly, D. R., Kuklik, P., Chia, N., & Sanders, P. (2010). Heart failure differentially affects the electrophysiological properties of adjacent heart regions implicated in persistent atrial fibrillation. In EUROPEAN HEART JOURNAL Vol. 31 (pp. 569). Stockholm, SWEDEN: OXFORD UNIV PRESS.
2010 Alasady, M., Mackenzie, L., Lau, D., Brooks, A., Saint, D., Barlow, D., . . . Sanders, P. (2010). Atrial ischemia rather than the neurohumoral or hemodynamic changes associted with myocardial infarction results in the substrate for atrial fibrillation. In EUROPEAN HEART JOURNAL Vol. 31 (pp. 1041). Stockholm, SWEDEN: OXFORD UNIV PRESS.
2010 Mackenzie, L., Dreyer, R., Kwok, Y., Kelly, D. R., Kuklik, P., Alasady, M., . . . Sanders, P. (2010). Atrial fibrotic structural remodelling as early as 3 hours post myocardial infarct: implications for atrial fibrillation. In EUROPEAN HEART JOURNAL Vol. 31 (pp. 643-644). Stockholm, SWEDEN: OXFORD UNIV PRESS.
2010 Mackenzie, L., Lau, D. H., Kelly, D. R., Brooks, A. G., Kuklik, P., & Sanders, P. (2010). Prolonged atrial fibrillation results in inferior left atrium and coronary sinus electrophysiological changes conducive to local re-entry. In EUROPEAN HEART JOURNAL Vol. 31 (pp. 710). Stockholm, SWEDEN: OXFORD UNIV PRESS.
2009 Lau, D. H., Mackenzie, L., Kelly, D. J., Kuklik, P., & Sanders, P. (2009). Atrial Remodeling Occurs Early With the Development of Hypertension in the Ovine Atria. In JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY Vol. 53 (pp. A463). Orlando, FL: ELSEVIER SCIENCE INC.
2008 Lau, D. H., Mackenzie, L., Rajendram, A., Rao, M., Russell, C., Goddard, K., . . . Sanders, P. (2008). DEVELOPMENT AND CHARACTERISATION OF THE CARDIOVASCULAR CHANGES IN A LARGE ANIMAL MODEL OF HYPERTENSION. In HYPERTENSION Vol. 52 (pp. 170). Adelaide, AUSTRALIA: LIPPINCOTT WILLIAMS & WILKINS.
2008 Lau, D. H., Mackenzie, L., Kelly, D. J., Worthington, M., Rajendram, A., Zhang, Y., . . . Sanders, P. (2008). Short Duration Hypertension is Associated with the Development of Substrate for Atrial Fibrillation. In CIRCULATION Vol. 118 (pp. S435). New Orleans, LA: LIPPINCOTT WILLIAMS & WILKINS.

Year Citation
2015 Brinn, M., Carson, K., To-A-Nan, R., Mackenzie, L., Medley, G., Liu, X., . . . Smith, B. (2015). CAN NICOTINE REPLACEMENT THERAPY DELIVERED VIA CONTINUOUS PATCH CAUSE AUTO-INDUCTION (UPREGULATION OF RECEPTORS)?: A PILOT STUDY. Poster session presented at the meeting of RESPIROLOGY. Queensland, AUSTRALIA: WILEY-BLACKWELL.
2009 Lau, D. H., Mackenzie, L., Kelly, D. J., Psaltis, P. J., Worthington, M., Rajendram, A., . . . Sanders, P. (2009). Hypertension and atrial fibrillation: a long term study of remodeling in a conscious ovine model. Poster session presented at the meeting of Abstracts of the 82nd Scientific Session of the American Heart Association, as published in Circulation. Orlando, FL: American Heart Association.
  • Optimizing sample preparation for analysis for Toxicokinetic and Toxicodynamic assessment, storage and tracking following Poison Exposures, NHMRC - Program Grant, 01/11/2016 - 31/12/2018

  • Refining regulatory toxicology through the integration of human clinical toxicology and mechanistic findings, Central Adelaide Local Health Network Incorporated, 04/07/2016 - 28/02/2017

  • Clinical toxicology of various consumer products and poisons after dermal exposure, Central Adelaide Local Health Network Incorporated, 04/07/2016 - 21/02/2017

Date Role Research Topic Program Degree Type Student Load Student Name
2022 External Supervisor - Doctor of Philosophy Doctorate Full Time Mr Joshua Dalton

Date Role Research Topic Program Degree Type Student Load Student Name
2009 - 2013 Co-Supervisor Obesity and Atrial Electrical and Mechanical Remodeling: Implications for Atrial Fibrillation Doctor of Philosophy Doctorate Full Time Dr Hany Samy Abed
2007 - 2008 Co-Supervisor Mechanoelectric Feedback in the Mammalian Heart Doctor of Philosophy Doctorate Full Time Dr Douglas Robert Kelly
2006 - 2010 Co-Supervisor Substrate for Atrial Fibrillation in Cardiomyopathies Doctor of Philosophy Doctorate Full Time Prof Dennis Lau

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