Imam Fathoni

Imam Fathoni

School of Biological Sciences

Faculty of Sciences, Engineering and Technology

Imam (Toni) Fathoni is a Technical Officer in the Malaria and Toxoplasma Laboratory at the School of Biological Sciences, Adelaide University. He is working on developing a research model for Cryptosporidium, a parasite that causes gastrointestinal infections. Toni is finishing his PhD at the Australian National University under the supervision of Kevin Saliba, where he investigated thiamine (vitamin B1) metabolism as a potential drug target against malaria parasites, Plasmodium. He also completed a one-year research exchange at Humboldt University Berlin under the supervision of Kai Matuschewski. He has expertise in both in vitro and in vivo models of malaria parasites. Before moving to Adelaide, he worked as a laboratory officer at Diversity Arrays Technology, where he was part of the Research and Development department, developing a high-throughput method for soil DNA extraction to investigate microbial biodiversity in soil.

  • Appointments
    Date Position Institution name
    2025 - ongoing Technical Officer Adelaide University
    2023 - 2025 Laboratory Officer Diversity Arrays Technology (DArT)
    2020 - 2022 Technical Assistant Australian National University

  • Language Competencies
    Language Competency
    English Can read, write, speak, understand spoken and peer review

  • Education
    Date Institution name Country Title
    2022 - 2023 Humboldt-Universität zu Berlin Germany PhD (research exchange)
    2020 - 2025 Australian National University Australia PhD

  • Research Interests
    Medical Parasitology Biochemistry & Molecular Biology

  • Journals
    Year Citation
    2024 Fathoni, I., Ho, T. C. S., Chan, A. H. Y., Leeper, F. J., Matuschewski, K., & Saliba, K. J. (2024). Identification and characterization of thiamine analogs with antiplasmodial activity. Antimicrobial Agents and Chemotherapy, 68(12).
    DOI
    2024 Redway, A., Spry, C., Brown, A., Wiedemann, U., Fathoni, I., Garnie, L. F., . . . Downer-Riley, N. (2024). Discovery of antiplasmodial pyridine carboxamides and thiocarboxamides. International Journal for Parasitology Drugs and Drug Resistance, 25, 100536.
    DOI Scopus2 Europe PMC1
    2023 Chan, A. H. Y., Ho, T. C. S., Fathoni, I., Pope, R., Saliba, K. J., & Leeper, F. J. (2023). Inhibition of Thiamine Diphosphate-Dependent Enzymes by Triazole-Based Thiamine Analogues. ACS Medicinal Chemistry Letters, 14(5), 621-628.
    DOI Scopus9 Europe PMC9
    2023 El Bakali, J., Blaszczyk, M., Evans, J. C., Boland, J. A., McCarthy, W. J., Fathoni, I., . . . Spry, C. (2023). Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference.. Angewandte Chemie (International ed. in English), 62(17), e202300221.
    DOI Scopus6 Europe PMC8
    2022 Chan, A. H. Y., Fathoni, I., Ho, T. C. S., Saliba, K. J., & Leeper, F. J. (2022). Thiamine analogues as inhibitors of pyruvate dehydrogenase and discovery of a thiamine analogue with non-thiamine related antiplasmodial activity. RSC MEDICINAL CHEMISTRY, 13(7), 817-821.
    DOI
    2020 Fathoni, I., Petitbois, J. G., Alarif, W. M., Abdel-Lateff, A., Al-Lihaibi, S. S., Yoshimura, E., . . . Okino, T. (2020). Bioactivities of Lyngbyabellins from Cyanobacteria of <i>Moorea</i> and <i>Okeania</i> Genera. MOLECULES, 25(17), 9 pages.
    DOI Europe PMC8
    - Chan, A. H. Y., Ho, T. C. S., Fathoni, I., Hamid, R., Hirsch, A. K. H., Saliba, K. J., & Leeper, F. J. (2024). Evaluation of ketoclomazone and its analogues as inhibitors of 1-deoxy-<scp>d</scp>-xylulose 5-phosphate synthases and other thiamine diphosphate (ThDP)-dependent enzymes. RSC Medicinal Chemistry, 15(5), 1773-1781.
    DOI
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