Tanja Jankovic-Karasoulos
Adelaide Medical School
Faculty of Health and Medical Sciences
I am a postdoctoral research fellow in the School of Medicine, Discipline of Obstetrics and Gynaecology, and the Robinson Research Institute. My current research involves characterisation of molecular processes involved in placental development across gestation and how these are disrupted in pregnancy complications. Defects in placentation, characterised by impaired placental trophoblast cell invasion and poor remodelling of the maternal uterine spiral arterioles, significantly contribute to pregnancy complications including preeclampsia (PE), intrauterine growth restriction (IUGR) and preterm labour. Currently there is little in routine clinical practice that monitors the health of the placenta. My research is focussed on defining the human placental transcriptome and epigenome, and determining the molecular regulation of key pregnancy processes, including normal placental trophoblast invasion and placental function. I have established a primary trophoblast cell culture model, and together with my expertise with ex-vivo tissue culture explant models, I am able to perform gene functional studies in human trophoblasts from both uncomplicated and complicated pregnancies. These studies aim to identify potential therapeutic targets and biomarkers of pregnancy complications.
I am a postdoctoral research fellow in the School of Medicine, Discipline of Obstetrics and Gynaecology, and the Robinson Research Institute. My current research involves characterisation of molecular processes involved in placental development across gestation and how these are disrupted in pregnancy complications. Defects in placentation, characterised by impaired placental trophoblast cell invasion and poor remodelling of the maternal uterine spiral arterioles, significantly contribute to pregnancy complications including preeclampsia (PE), intrauterine growth restriction (IUGR) and preterm labour. Currently there is little in routine clinical practice that monitors the health of the placenta. My research is focussed on defining the human placental transcriptome and epigenome, and determining the molecular regulation of key pregnancy processes, including normal placental trophoblast invasion and placental function. I have established a primary trophoblast cell culture model, and together with my expertise with ex-vivo tissue culture explant models, I am able to perform gene functional studies in human trophoblasts from both uncomplicated and complicated pregnancies. These studies aim to identify potential therapeutic targets and biomarkers of pregnancy complications.
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Journals
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Conference Papers
Year Citation 2017 Wilson, R. L., Jankovic-Karasoulous, T., McAninch, D., Roberts, C. T., & Bianco-Miotto, T. (2017). IMMUNOLOCALISATION OF 5-METHYLCYTOSINE AND 5HYDROXYMETHYLCYTOSINE IN THE PLACENTA ACROSS GESTATION REVEALS DYNAMIC CO -LOCALISATION OF EXPRESSION. In PLACENTA Vol. 57 (pp. 260-261). Manchester, ENGLAND: W B SAUNDERS CO LTD.
DOI2010 Bayliss, J., Jankovic-Karasoulos, T., Bowden, S., Glogowski, I., & McLean, C. A. (2010). Latent brain JC polyomavirus: the role of immunosuppression and site of viral latency. In BRAIN PATHOLOGY Vol. 20 (pp. 81). Salzburg, AUSTRIA: WILEY-BLACKWELL PUBLISHING, INC. -
Conference Items
Year Citation 2020 Breen, J., Smith, M., McAninch, D., Jankovic-Karasoulos, T., McCullough, D., Pederson, S. M., . . . Roberts, C. (2020). Defining Co-expression Patterns and Molecular Pathways of the Placenta During Early Pregnancy.. Poster session presented at the meeting of REPRODUCTIVE SCIENCES. Vancouver, CANADA: SPRINGER HEIDELBERG. 2020 Wan, Q., Breen, J., Leemaqz, S. Y. -L., Pederson, S. M., Jankovic-Karasoulos, T., McAninch, D. C., . . . Bianco-Miotto, T. (2020). Characterisation of Placental DNA Methylation Across Early Human Gestation.. Poster session presented at the meeting of REPRODUCTIVE SCIENCES. Vancouver, CANADA: SPRINGER HEIDELBERG. 2020 Roberts, C. T., Leemaqz, S., Jankovic-Karasoulos, T., Grieger, J., McCullough, D., & Dekker, G. (2020). Rising Gestational Diabetes Mellitus: It's Not Just About Maternal Obesity. Poster session presented at the meeting of REPRODUCTIVE SCIENCES. Vancouver, CANADA: SPRINGER HEIDELBERG. 2016 Wilson, R., Leemaqz, S., Goh, Z., McAninch, D., Jankovic-Karasoulos, T., Bianco-Miotto, T., & Roberts, C. (2016). ZINC DEFICIENCY ALTERS PLACENTAL DEVELOPMENT AND MATERNAL HEMODYNAMICS CONTRIBUTING TO FETAL GROWTH RESTRICTION IN MICE. Poster session presented at the meeting of PLACENTA. Portland, OR: W B SAUNDERS CO LTD.
DOI2009 Jankovic-Karasoulos, T., Birrell, S. N., Cops, E. J., Jindal, S., Ochnik, A., Thomas, M., . . . Hickey, T. E. (2009). Evaluation of testosterone supplementation during anastrozole therapy in a breast explant model. Poster session presented at the meeting of Cancer Research. San Antonio, Texas: American Association for Cancer Research.
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2018 Co-Supervisor Impact of Maternal Micronutrient Deficiency on Placental Function and Pregnancy Outcome Doctor of Philosophy Doctorate Full Time Mrs Martha Menberu -
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2018 - 2020 Co-Supervisor The Effect of Micronutrients in Oxidative Stress, Proliferation and Apoptosis in Placenta Doctor of Philosophy Doctorate Full Time Ms Nahal Habibi
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