Dr Simran Kaur
Senior Biostatistician and Data Science Lead
SAIGENCI
College of Health
Dr. Simran Kaur is leading the Data Sciences Unit within the Computational Systems Oncology program at SAiGENCI. Her research focuses on the integration of clinical, genomic, and epidemiological data to investigate disease mechanisms and develop improved genetic risk scores applicable to multi-ethnic populations.
Simran completed her PhD in Bioinformatics and Biostatistics under the supervision of Professor Flemming Pociot at the University of Copenhagen, Denmark. In her PhD studies, she focused on understanding the genetic architecture of immune-mediated diseases and established computational pipelines to identify and prioritize disease associated non-coding variants. Following her PhD, Simran held postdoctoral and faculty positions at the Steno Diabetes Centre Copenhagen where she investigated roles of aberrantly expressed non-coding RNAs (including miRNAs, lncRNAs and circular RNAs) in pancreatic islets and human pancreatic β-cell lines following pro-inflammatory cytokines exposure. She has extensive experience working with large-scale national and international cohorts, managing and analyzing complex, high-dimensional genomic and clinical datasets. Her current research interests include applying computational fine-mapping approaches to disentangle genetic risk and investigating HLA-mediated genetic pleiotropy across autoimmune diseases and cancers.
As Senior Biostatistician and Data Sciences Lead, Simran collaborates with multidisciplinary teams at SAiGENCI to translate data-driven findings into insights that support precision medicine and improve patient outcomes.
| Date | Position | Institution name |
|---|---|---|
| 2025 - ongoing | Senior Biostatistician and Data Science Lead | University of Adelaide |
| 2019 - 2025 | Assistant Professor | Steno Diabetes Center Copenhagen |
| 2017 - 2018 | Post Doctoral Researcher | Steno Diabetes Center |
| 2015 - 2017 | Post Doctoral Researcher | Herlev and Gentofte Hospital |
| 2011 - 2015 | PhD fellow | University of Copenhagen |
| 2009 - 2010 | Senior Research Fellow | National Institute of Pharmaceutical Education and Research |
| 2007 - 2009 | Junior Research Fellow | National Institute of Pharmaceutical Education and Research |
| Date | Institution name | Country | Title |
|---|---|---|---|
| 2011 - 2015 | University of Copenhagen | Denmark | PhD |
| 2005 - 2007 | Panjab University | India | MSc |
| Year | Citation |
|---|---|
| 2025 | Yarani, R., Primavera, R., Chetty, S., Wang, J., Kaur, S., Haupt-Jorgensen, M., . . . Thakor, A. S. (2025). Preventing the onset of diabetes with precision delivery of mesenchymal stem cells to the pancreas in a preclinical model.. Stem cell research & therapy, 16(1), 11 pages. |
| 2025 | Joglekar, M. V., Wong, W. K. M., Kunte, P. S., Hardikar, H. P., Kulkarni, R. A., Ahmed, I., . . . Hardikar, A. A. (2025). A microRNA-based dynamic risk score for type 1 diabetes. Nature Medicine, 31(8), 2622-2631. Scopus8 WoS9 Europe PMC7 |
| 2025 | Mønsted, M., Pedersen, K., Jensen, M. H., Kaur, S., Sustacha, S. C., Holm, L. J., . . . Haupt-Jorgensen, M. (2025). Genetic and transcriptional dysregulation of innate antiviral immune pathways in type 1 diabetes. Immunology Letters, 276, 9 pages. |
| 2024 | Joglekar, M. V., Kaur, S., Pociot, F., & Hardikar, A. A. (2024). Prediction of progression to type 1 diabetes with dynamic biomarkers and risk scores. The Lancet Diabetes and Endocrinology, 12(7), 483-492. Scopus11 WoS11 Europe PMC12 |
| 2024 | Armenteros, J. J. A., Brorsson, C., Johansen, C. H., Banasik, K., Mazzoni, G., Moulder, R., . . . Brunak, S. (2024). Multi-omics analysis reveals drivers of loss of β-cell function after newly diagnosed autoimmune type 1 diabetes: An INNODIA multicenter study. Diabetes Metabolism Research and Reviews, 40(5), 15 pages. Scopus11 WoS12 Europe PMC13 |
| 2024 | Greve, J. H., Mørk, F., Jensen, A. K., Kaur, S., Madsen, J. O. B., Bugge, A., . . . Johannesen, J. (2024). Lipid levels in a cohort of healthy Danish schoolchildren ages 5 to 17 years. Scandinavian Journal of Clinical and Laboratory Investigation, 84(4), 285-295. Scopus2 WoS2 Europe PMC1 |
| 2024 | Marcovecchio, M. L., Hendriks, A. E. J., Delfin, C., Battelino, T., Danne, T., Evans, M. L., . . . Mathieu, C. (2024). The INNODIA Type 1 Diabetes Natural History Study: a European cohort of newly diagnosed children, adolescents and adults. Diabetologia, 67(6), 995-1008. Scopus23 WoS22 Europe PMC18 |
| 2023 | Rudman, N., Kaur, S., Simunović, V., Kifer, D., Šoić, D., Keser, T., . . . Gornik, O. (2023). Integrated glycomics and genetics analyses reveal a potential role for N-glycosylation of plasma proteins and IgGs, as well as the complement system, in the development of type 1 diabetes. Diabetologia, 66(6), 1071-1083. Scopus14 WoS16 Europe PMC14 |
| 2023 | Thorsen, S. U., Liu, X., Kataria, Y., Mandrup-Poulsen, T., Kaur, S., Uusitalo, U., . . . Svensson, J. (2023). Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study. Diabetes Care, 46(5), 1014-1018. Scopus5 WoS7 Europe PMC6 |
| 2023 | Mohammadi-Motlagh, H. R., Sadeghalvad, M., Yavari, N., Primavera, R., Soltani, S., Chetty, S., . . . Yarani, R. (2023). β Cell and Autophagy: What Do We Know?. Biomolecules, 13(4), 25 pages. Scopus18 WoS19 Europe PMC18 |
| 2023 | Frørup, C., Gerwig, R., Svane, C. A. S., Mendes Lopes de Melo, J., Henriksen, K., Fløyel, T., . . . Størling, J. (2023). Characterization of the functional and transcriptomic effects of pro-inflammatory cytokines on human EndoC-βH5 beta cells. Frontiers in Endocrinology, 14, 15 pages. Scopus14 WoS14 Europe PMC18 |
| 2022 | Rudman, N., Kifer, D., Kaur, S., Simunović, V., Cvetko, A., Pociot, F., . . . Gornik, O. (2022). Children at onset of type 1 diabetes show altered N-glycosylation of plasma proteins and IgG. Diabetologia, 65(8), 1315-1327. Scopus23 WoS24 Europe PMC24 |
| 2022 | Mansachs, S. J., Villumsen, S. O., Johannesen, J., Lind, A., Kaur, S., & Pociot, F. (2022). Genetic Variants Associated with Neuropeptide Y Autoantibody Levels in Newly Diagnosed Individuals with Type 1 Diabetes. Genes, 13(5), 13 pages. Scopus3 WoS3 Europe PMC2 |
| 2022 | Kaur, S., Frørup, C., Mirza, A. H., Fløyel, T., Yarani, R., Colli, M. L., . . . Pociot, F. (2022). Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells. Non Coding RNA, 8(5), 19 pages. Scopus3 WoS3 Europe PMC3 |
| 2021 | Kaur, S., Mirza, A. H., Overgaard, A. J., Pociot, F., & Størling, J. (2021). A Dual Systems Genetics Approach Identifies Common Genes, Networks, and Pathways for Type 1 and 2 Diabetes in Human Islets. Frontiers in Genetics, 12, 13 pages. Scopus18 WoS18 Europe PMC19 |
| 2021 | Frørup, C., Mirza, A. H., Yarani, R., Nielsen, L. B., Mathiesen, E. R., Damm, P., . . . Kaur, S. (2021). Plasma Exosome-Enriched Extracellular Vesicles From Lactating Mothers With Type 1 Diabetes Contain Aberrant Levels of miRNAs During the Postpartum Period. Frontiers in Immunology, 12, 11 pages. Scopus21 WoS23 Europe PMC22 |
| 2021 | Pedersen, K., Haupt-Jorgensen, M., Krogvold, L., Kaur, S., Gerling, I. C., Pociot, F., . . . Buschard, K. (2021). Genetic predisposition in the 2′-5′A pathway in the development of type 1 diabetes: potential contribution to dysregulation of innate antiviral immunity. Diabetologia, 64(8), 1805-1815. Scopus23 WoS23 Europe PMC21 |
| 2021 | Fløyel, T., Meyerovich, K., Prause, M. C., Kaur, S., Frørup, C., Mortensen, H. B., . . . Størling, J. (2021). Skap2, a candidate gene for type 1 diabetes, regulates b-cell apoptosis and glycemic control in newly diagnosed patients. Diabetes, 70(2), 464-476. Scopus12 WoS12 Europe PMC11 |
| 2021 | BRORSSON, C., ARMENTEROS, J. J. A., MAZZONI, G., KAUR, S., SCHULTE, A. M., MATHIEU, C., & BRUNAK, S. (2021). 1111-P: Integrating Longitudinal Clinical and Baseline Multiomics Data for Predicting C-Peptide Progression in Newly Diagnosed Type 1 Diabetes. Diabetes, 70(Supplement_1). |
| 2020 | Andersson Svärd, A., Kaur, S., Trôst, K., Suvitaival, T., Lernmark, Å., Maziarz, M., . . . Neiderud, J. (2020). Characterization of plasma lipidomics in adolescent subjects with increased risk for type 1 diabetes in the DiPiS cohort. Metabolomics, 16(10), 14 pages. Scopus3 WoS2 Europe PMC1 |
| 2020 | Fløyel, T., Mirza, A. H., Kaur, S., Frørup, C., Yarani, R., Størling, J., & Pociot, F. (2020). The Rac2 GTPase contributes to cathepsin H-mediated protection against cytokine-induced apoptosis in insulin-secreting cells. Molecular and Cellular Endocrinology, 518, 11 pages. Scopus15 WoS16 Europe PMC15 |
| 2019 | Mirza, A. H., Kaur, S., Nielsen, L. B., Størling, J., Yarani, R., Roursgaard, M., . . . Pociot, F. (2019). Breast milk-derived extracellular vesicles enriched in exosomes from mothers with type 1 diabetes contain aberrant levels of micrornas. Frontiers in Immunology, 10(OCT), 10 pages. Scopus100 WoS94 Europe PMC79 |
| 2019 | Yasmeen, S., Kaur, S., Mirza, A. H., Brodin, B., Pociot, F., & Kruuse, C. (2019). miRNA-27a-3p and miRNA-222-3p as Novel Modulators of Phosphodiesterase 3a (PDE3A) in Cerebral Microvascular Endothelial Cells. Molecular Neurobiology, 56(8), 5304-5314. Scopus39 WoS34 Europe PMC29 |
| 2019 | Yarani, R., Mirza, A. H., Kaur, S., & Pociot, F. (2019). Tu1766 – Dysregulated Lncrnas in Inflammatory Bowel Disease Demonstrate Immune System Related Association Through Guilt-By Association Analysis. Gastroenterology, 156(6), S-1116. |
| 2018 | Vestergaard, A. L., Bang-Berthelsen, C. H., Fløyel, T., Stahl, J. L., Christen, L., Sotudeh, F. T., . . . Mandrup-Poulsen, T. (2018). MicroRNAs and histone deacetylase inhibition-mediated protection against inflammatory β-cell damage. Plos One, 13(9), 22 pages. Scopus22 WoS24 Europe PMC21 |
| 2018 | Holm, L. J., Krogvold, L., Hasselby, J. P., Kaur, S., Claessens, L. A., Russell, M. A., . . . Buschard, K. (2018). Abnormal islet sphingolipid metabolism in type 1 diabetes. Diabetologia, 61(7), 1650-1661. Scopus72 WoS67 Europe PMC69 |
| 2018 | Samandari, N., Mirza, A. H., Kaur, S., Hougaard, P., Nielsen, L. B., Fredheim, S., . . . Pociot, F. (2018). Influence of disease duration on circulating levels of miRNAs in children and adolescents with new onset type 1 diabetes. Non Coding RNA, 4(4), E35. Scopus28 Europe PMC19 |
| 2018 | Nielsen, K. O., Mirza, A. H., Kaur, S., Jacobsen, K. S., Winther, T. N., Glebe, D., . . . Størling, J. (2018). Hepatitis B virus suppresses the secretion of insulin-like growth factor binding protein 1 to facilitate anti-apoptotic IGF-1 effects in HepG2 cells. Experimental Cell Research, 370(2), 399-408. Scopus13 WoS14 Europe PMC11 |
| 2018 | Kaur, S., Mirza, A. H., & Pociot, F. (2018). Cell type-selective expression of circular RNAs in human pancreatic islets. Non Coding RNA, 4(4), E38. Scopus32 Europe PMC28 |
| 2018 | Kaur, S., & Pociot, F. (2018). miRNAs regulate development and function of regulatory T-cells in recent onset islet autoimmunity in pre-Type 1 diabetes. Non Coding RNA Investigation, 2(3), 16. Scopus3 |
| 2018 | Yarani, R., Mirza, A. H., Kaur, S., & Pociot, F. (2018). The emerging role of lncrnas in inflammatory bowel disease. Experimental and Molecular Medicine, 50(12), 14 pages. Scopus131 WoS131 Europe PMC112 |
| 2017 | Mirza, A. H., Kaur, S., & Pociot, F. (2017). Long non-coding RNAs as novel players in β cell function and type 1 diabetes. Human Genomics, 11(1), 10 pages. Scopus48 WoS47 Europe PMC41 |
| 2017 | Samandari, N., Mirza, A. H., Nielsen, L. B., Kaur, S., Hougaard, P., Fredheim, S., . . . Pociot, F. (2017). Circulating microRNA levels predict residual beta cell function and glycaemic control in children with type 1 diabetes mellitus. Diabetologia, 60(2), 354-363. Scopus70 WoS66 Europe PMC57 |
| 2016 | Kaur, S., Mirza, A. H., Brorsson, C. A., Fløyel, T., Størling, J., Mortensen, H. B., . . . Åman, J. (2016). The genetic and regulatory architecture of ERBB3-type 1 diabetes susceptibility locus. Molecular and Cellular Endocrinology, 419(C), 83-91. Scopus35 WoS33 Europe PMC32 |
| 2016 | Pociot, F., Kaur, S., & Nielsen, L. B. (2016). Effects of the genome on immune regulation in type 1 diabetes. Pediatric Diabetes, 17, 37-42. Scopus10 WoS9 Europe PMC8 |
| 2016 | Overgaard, A. J., Kaur, S., & Pociot, F. (2016). Metabolomic Biomarkers in the Progression to Type 1 Diabetes. Current Diabetes Reports, 16(12), 5 pages. Scopus15 WoS15 Europe PMC12 |
| 2016 | Brorsson, C. A., Nielsen, L. B., Andersen, M. L., Kaur, S., Bergholdt, R., Hansen, L., . . . Størling, J. (2016). Genetic risk score modelling for disease progression in new-onset type 1 diabetes patients: Increased genetic load of islet-expressed and cytokine-regulated candidate genes predicts poorer glycemic control. Journal of Diabetes Research, 2016, 8 pages. Scopus18 WoS18 Europe PMC19 |
| 2015 | Kaur, S., & Pociot, F. (2015). Alu elements as novel regulators of gene expression in type 1 diabetes susceptibility genes?. Genes, 6(3), 577-591. Scopus7 WoS8 Europe PMC5 |
| 2015 | Fløyel, T., Kaur, S., & Pociot, F. (2015). Genes Affecting β-Cell Function in Type 1 Diabetes. Current Diabetes Reports, 15(11), 11 pages. Scopus46 WoS39 Europe PMC37 |
| 2014 | Mirza, A. H., Kaur, S., Brorsson, C. A., & Pociot, F. (2014). Effects of GWAS-associated genetic variants on lncRNAs within IBD and T1D candidate loci. Plos One, 9(8), 15 pages. Scopus71 WoS71 Europe PMC62 |
| 2013 | Lima, R. T., Barron, G. A., Grabowska, J. A., Bermano, G., Kaur, S., Roy, N., . . . Lin, P. K. T. (2013). Cytotoxicity and cell death mechanisms induced by a novel bisnaphthalimidopropyl derivative against the NCI-H460 non-small lung cancer cell line. Anti Cancer Agents in Medicinal Chemistry, 13(3), 414-421. Scopus13 WoS13 Europe PMC7 |
| 2012 | Havgaard, J., Kaur, S., & Gorodkin, J. (2012). Comparative ncRNA gene and structure prediction using foldalign and foldalignM. Current Protocols in Bioinformatics, Chapter 12(SUPPL.39), 12.11.1-12.11.15. Scopus5 Europe PMC4 |
| 2012 | Lima, R. T., Barron, G., Grabowska, J. A., Bermano, G., Kaur, S., Roy, N., . . . Lin, P. K. (2012). Bisnaphthalimidopropyl Derivatives as Antitumor Agents - Targeting SIRT2. EUROPEAN JOURNAL OF CANCER, 48, S243. |
| 2010 | Tavares, J., Ouaissi, A., Lin, P. K. T., Loureiro, I., Kaur, S., Roy, N., & Cordeiro-da-Silva, A. (2010). Bisnaphthalimidopropyl derivatives as inhibitors of Leishmania SIR2 related protein 1. Chemmedchem, 5(1), 140-147. Scopus52 WoS49 Europe PMC39 |
| 2010 | Pahwa, S., Kaur, S., Jain, R., & Roy, N. (2010). Structure based design of novel inhibitors for histidinol dehydrogenase from Geotrichum candidum. Bioorganic and Medicinal Chemistry Letters, 20(13), 3972-3976. Scopus13 WoS8 Europe PMC8 |
| 2010 | Kaur, S., Modi, N. H., Panda, D., & Roy, N. (2010). Probing the binding site of curcumin in Escherichia coli and Bacillus subtilis FtsZ - A structural insight to unveil antibacterial activity of curcumin. European Journal of Medicinal Chemistry, 45(9), 4209-4214. Scopus184 WoS166 Europe PMC107 |
| 2010 | Kaur, S., Shivange, A. V., & Roy, N. (2010). Structural analysis of trypanosomal sirtuin: An insight for selective drug design. Molecular Diversity, 14(1), 169-178. Scopus14 WoS13 Europe PMC11 |
| 2009 | Kaur, S., Patel, H., Sharma, V., Garg, P., & Roy, N. (2009). LeishBase: Leishmania major structural database. International Journal of Integrative Biology, 7(2), 63-68. Scopus7 |
| - | Kaur, S., U., D. L., Frorup, C., Otto, B. M. J., Krogvold, L., C., G. I., . . . Floyel, T. (2025). Cathepsin s is elevated in pancreatic islets and plasma in new-onset type 1 diabetes and positively associates with systemic inflammatory cytokines. Endocrine Abstracts. |
| Year | Citation |
|---|---|
| 2020 | Kaur, S., Frørup, C., Jensen, V. H., Mirza, A. H., de Melo, J. M. L., Yarani, R., . . . Pociot, F. (2020). Long Noncoding RNAs in Diabetes and β-Cell Regulation. In S. Jurga, & J. Barciszewski (Eds.), RNA Technologies (Vol. 11, pp. 523-544). SPRINGER INTERNATIONAL PUBLISHING AG. DOI Scopus1 WoS1 |
| Year | Citation |
|---|---|
| 2024 | Berg, A. K., Kaur, S., Storling, J., Thorsen, S. U., Thyssen, J. P., Zachariae, C., & Svensson, J. (2024). Filaggrin mutations and dermatological complications due to diabetes devices. In HORMONE RESEARCH IN PAEDIATRICS Vol. 97 (pp. 58). KARGER. |
| 2023 | Jensen, M. H., Pedersen, K., Kaur, S., Jensen-Dahm, A., Pociot, F., & Haupt-Jorgensen, M. (2023). Pancreatic dysregulation of innate antiviral immune pathways in type 1 diabetes. In DIABETOLOGIA Vol. 66 (pp. S177). GERMANY, Hamburg: SPRINGER. |
| 2019 | Gornik, O., Selak, N., Kaur, S., Kifer, D., Pociot, F., & Morahan, G. (2019). N-glycosylation of plasma proteins is changed in children with early onset type 1 diabetes and regulated by glycosyltransferase and complement C3 genes. In DIABETOLOGIA Vol. 62 (pp. S168). SPAIN, Barcelona: SPRINGER. |
| 2019 | Yarani, R., Mirza, A. H., Kaur, S., & Pociot, F. (2019). DYSREGULATED LNCRNAS IN INFLAMMATORY BOWEL DISEASE DEMONSTRATE IMMUNE SYSTEM RELATED ASSOCIATION THROUGH GUILT-BY ASSOCIATION ANALYSIS. In GASTROENTEROLOGY Vol. 156 (pp. S1116). CA, San Diego: W B SAUNDERS CO-ELSEVIER INC. |
| 2019 | Glyco25, XXV International Symposium on Glycoconjugates (2019). In Glycoconjugate Journal Vol. 36 (pp. 267-397). United States: Springer Science and Business Media LLC. DOI Scopus2 Europe PMC2 |
| 2018 | Kaur, S., Mirza, A. H., Pociot, F., & Storling, J. (2018). A common regulatory network for type 1 and type 2 diabetes susceptibility genes in human pancreatic islets. In DIABETOLOGIA Vol. 61 (pp. S117). GERMANY, Berlin: SPRINGER. |
| 2018 | Overgaard, A. J., Kaur, S., Ali, A., Weir, J. M., Jayawardana, K., Mortensen, H. B., . . . Pociot, F. (2018). Identification of novel loci associated with lipid levels in recent-onset type 1 diabetes. In DIABETOLOGIA Vol. 61 (pp. S184-S185). GERMANY, Berlin: SPRINGER. |
| 2018 | Floyel, T., Mirza, A. H., Kaur, S., Storling, J., & Pociot, F. (2018). The type 1 diabetes candidate gene CTSH protects against cytokine-induced beta cell apoptosis via Rac2 GTPase. In DIABETOLOGIA Vol. 61 (pp. S200). GERMANY, Berlin: SPRINGER. |
| 2015 | Floyel, T., Mirza, A. H., Kaur, S., & Pociot, F. (2015). The protective effect of cathepsin H on beta cell apoptosis is mediated through the Jak-STAT and NFkappaB signalling pathways. In DIABETOLOGIA Vol. 58 (pp. S200). SWEDEN, Stockholm: SPRINGER. |
| Year | Citation |
|---|---|
| 2024 | Joglekar, M., Wong, W. K. M., Kunte, P., Kulkarni, R., Ahmed, I., Farr, R., . . . PREDICT T1D Study Group. (2024). Applicability of a microRNA-based dynamic risk score for type 1 diabetes. DOI |
| 2024 | Hardikar, A., Joglekar, M., Wong, W., Kunte, P., Kulkarni, R., Ahmed, I., . . . Pociot, F. (2024). Applicability of a microRNA-based dynamic risk score for type 1 diabetes. DOI |
| 2024 | Henriksen, K., Jørgensen, A., Kaur, S., Gerwig, R., Svane, C. A. B., Knop, F., & Størling, J. (2024). Exploring the functional, protective, and transcriptomic effects of GIP on cytokine-exposed human pancreatic islets and EndoC-βH5 cells. DOI |
| 2022 | Frørup, C., Gerwig, R., Søndergaard Svane, C. A., Mendes Lopes de Melo, J., Fløyel, T., Pociot, F., . . . Størling, J. (2022). Characterisation of the functional and transcriptomic effects of pro-inflammatory cytokines on human EndoC-βH5 beta cells. DOI |
| 2018 | Samandari, N., Mirza, A., Kaur, S., Hougaard, P., Nielsen, L. B., Fredheim, S., . . . Pociot, F. (2018). Influence of Disease Duration on Circulating Levels of miRNAs in Children and Adolescents with New Onset Type 1 Diabetes. DOI Europe PMC1 |
| Date | Role | Committee | Institution | Country |
|---|---|---|---|---|
| 2026 - ongoing | Member | ABACBS Professional Bioinformatics Community (APBC) | ABACBS | Australia |
| Date | Role | Editorial Board Name | Institution | Country |
|---|---|---|---|---|
| 2024 - ongoing | Associate Editor | Molecular Biology Reports: an international journal on molecular and cellular biology | Springer Nature | United States |
| 2023 - ongoing | Associate Editor | Frontiers in RNA Research | Frontiers | United States |
| 2020 - ongoing | Editor | Frontiers in Genetics | Frontiers | United States |
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