Dr Beatriz Jimenez Garrido
Senior Lecturer
School of Physics, Chemistry and Earth Sciences
Faculty of Sciences, Engineering and Technology
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Journals
Year Citation 2025 Antcliffe, D. B., Harte, E., Hussain, H., Jiménez, B., Browning, C., & Gordon, A. C. (2025). Metabolic septic shock sub-phenotypes, stability over time and association with clinical outcome. Intensive Care Medicine, 51(3), 529-541.
2025 Yan, Y., Jiménez, B., Judge, M. T., Athersuch, T., De Iorio, M., & Ebbels, T. M. D. (2025). MetAssimulo 2.0: a web app for simulating realistic 1D and 2D metabolomic <sup>1</sup>H NMR spectra. Bioinformatics, 41(3), btaf045.
2025 Xu, K., Hernández, B., Arpawong, T. E., Camuzeaux, S., Chekmeneva, E., Crimmins, E. M., . . . Robinson, O. (2025). Assessing Metabolic Ageing via DNA Methylation Surrogate Markers: A Multicohort Study in Britain, Ireland and the USA. Aging Cell, 24(5), e14484.
2024 Yan, Y., Judge, M. T., Athersuch, T., Xiang, Y., Liu, Z., Jiménez, B., & Ebbels, T. M. D. (2024). Resolution Enhancement of Metabolomic J-Res NMR Spectra Using Deep Learning. Analytical Chemistry, 96(29), 11707-11715.
Scopus4 Europe PMC22024 Trainor, N., Whitwell, H. J., Jiménez, B., Addison, K., Leonidou, E., DiMaggio, P. A., & Fuchter, M. J. (2024). Tracking DOT1L methyltransferase activity by stable isotope labelling using a selective synthetic co-factor. Communications Chemistry, 7(1), 145.
Scopus12023 Alexander, J. L., Wyatt, N. J., Camuzeaux, S., Chekmeneva, E., Jimenez, B., Sands, C. J., . . . Lamb, C. A. (2023). Considerations for peripheral blood transport and storage during large-scale multicentre metabolome research. Gut, 73(2), 379-383.
Scopus3 Europe PMC12023 Garcia‐Segura, M. E., Durainayagam, B. R., Liggi, S., Graça, G., Jimenez, B., Dehghan, A., . . . Griffin, J. L. (2023). Pathway‐based integration of multi‐omics data reveals lipidomics alterations validated in an Alzheimer's disease mouse model and risk loci carriers. Journal of Neurochemistry, 164(1), 57-76.
Scopus11 Europe PMC132023 Harvey, N., Takis, P. G., Lindon, J. C., Li, J. V., & Jiménez, B. (2023). Optimization of Diffusion-Ordered NMR Spectroscopy Experiments for High-Throughput Automation in Human Metabolic Phenotyping. Analytical Chemistry, 95(6), 3147-3152.
Scopus6 Europe PMC22022 Hussain, H., Vutipongsatorn, K., Jiménez, B., & Antcliffe, D. B. (2022). Patient Stratification in Sepsis: Using Metabolomics to Detect Clinical Phenotypes, Sub-Phenotypes and Therapeutic Response. Metabolites, 12(5), 42 pages.
Scopus24 Europe PMC222022 Sliz, E., Shin, J., Ahmad, S., Williams, D. M., Frenzel, S., Gauß, F., . . . Pausova, Z. (2022). Circulating Metabolome and White Matter Hyperintensities in Women and Men. Circulation, 145(14), 1040-1052.
Scopus21 Europe PMC212022 Albreht, A., Hussain, H., Jiménez, B., Yuen, A. H. Y., Whiley, L., Witt, M., . . . Chekmeneva, E. (2022). Structure Elucidation and Mitigation of Endogenous Interferences in LC-MS-Based Metabolic Profiling of Urine. Analytical Chemistry, 94(3), 1760-1768.
Scopus7 Europe PMC52021 Takis, P. G., Jiménez, B., Al-Saffar, N. M. S., Harvey, N., Chekmeneva, E., Misra, S., & Lewis, M. R. (2021). A Computationally Lightweight Algorithm for Deriving Reliable Metabolite Panel Measurements from 1D <sup>1</sup>H NMR. Analytical Chemistry, 93(12), 4995-5000.
Scopus6 Europe PMC52021 Whiley, L., Chappell, K. E., D’Hondt, E., Lewis, M. R., Jiménez, B., Snowden, S. G., . . . Holmes, E. (2021). Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer’s disease. Alzheimer's Research and Therapy, 13(1), 18 pages.
Scopus80 Europe PMC642021 Jiménez, B., Abellona U, M. R., Drymousis, P., Kyriakides, M., Clift, A. K., Liu, D. S. K., . . . Frilling, A. (2021). Neuroendocrine neoplasms: Identification of novel metabolic circuits of potential diagnostic utility. Cancers, 13(3), 1-17.
Scopus3 Europe PMC22020 Andreas, N. J., Basu Roy, R., Gomez-Romero, M., Horneffer-van der Sluis, V., Lewis, M. R., Camuzeaux, S. S. M., . . . Kampmann, B. (2020). Performance of metabonomic serum analysis for diagnostics in paediatric tuberculosis. Scientific Reports, 10(1), 11 pages.
Scopus10 Europe PMC92020 Kurbatova, N., Garg, M., Whiley, L., Chekmeneva, E., Jiménez, B., Gómez-Romero, M., . . . Lovestone, S. (2020). Urinary metabolic phenotyping for Alzheimer’s disease. Scientific Reports, 10(1), 17 pages.
Scopus31 Europe PMC262020 Takis, P. G., Jiménez, B., Sands, C. J., Chekmeneva, E., & Lewis, M. R. (2020). SMolESY: An efficient and quantitative alternative to on-instrument macromolecular <sup>1</sup>H-NMR signal suppression. Chemical Science, 11(23), 6000-6011.
Scopus18 Europe PMC132019 Rodriguez-Martinez, A., Ayala, R., Posma, J. M., Harvey, N., Jiménez, B., Sonomura, K., . . . Dumas, M. E. (2019). PJRES Binning Algorithm (JBA): A new method to facilitate the recovery of metabolic information from pJRES <sup>1</sup>H NMR spectra. Bioinformatics, 35(11), 1916-1922.
Scopus12 Europe PMC102019 Harbaum, L., Ghataorhe, P., Wharton, J., Jiménez, B., Howard, L. S. G., Gibbs, J. S. R., . . . Wilkins, M. R. (2019). Reduced plasma levels of small HDL particles transporting fibrinolytic proteins in pulmonary arterial hypertension. Thorax, 74(4), 380-389.
Scopus37 Europe PMC282019 Whiley, L., Chekmeneva, E., Berry, D. J., Jiménez, B., Yuen, A. H. Y., Salam, A., . . . Lewis, M. R. (2019). Systematic Isolation and Structure Elucidation of Urinary Metabolites Optimized for the Analytical-Scale Molecular Profiling Laboratory. Analytical Chemistry, 91(14), 8873-8882.
Scopus12 Europe PMC92019 Sands, C. J., Wolfer, A. M., Correia, G. D. S., Sadawi, N., Ahmed, A., Jiménez, B., . . . Pearce, J. T. M. (2019). The nPYc-Toolbox, a Python module for the pre-processing, quality-control and analysis of metabolic profiling datasets. Bioinformatics, 35(24), 5359-5360.
Scopus27 Europe PMC252018 Jiménez, B., Holmes, E., Heude, C., Tolson, R. F., Harvey, N., Lodge, S. L., . . . Nicholson, J. K. (2018). Quantitative Lipoprotein Subclass and Low Molecular Weight Metabolite Analysis in Human Serum and Plasma by <sup>1</sup>H NMR Spectroscopy in a Multilaboratory Trial. Analytical Chemistry, 90(20), 11962-11971.
Scopus176 Europe PMC1552018 Gafson, A. R., Thorne, T., McKechnie, C. I. J., Jimenez, B., Nicholas, R., & Matthews, P. M. (2018). Lipoprotein markers associated with disability from multiple sclerosis. Scientific Reports, 8(1), 8 pages.
Scopus28 Europe PMC222017 Rodriguez-Martinez, A., Posma, J. M., Ayala, R., Harvey, N., Jimenez, B., Neves, A. L., . . . Dumas, M. E. (2017). J-Resolved <sup>1</sup>H NMR 1D-Projections for Large-Scale Metabolic Phenotyping Studies: Application to Blood Plasma Analysis. Analytical Chemistry, 89(21), 11405-11412.
Scopus18 Europe PMC142017 Antcliffe, D., Jiménez, B., Veselkov, K., Holmes, E., & Gordon, A. C. (2017). Metabolic Profiling in Patients with Pneumonia on Intensive Care. EBioMedicine, 18, 244-253.
Scopus21 Europe PMC132017 Ferrario, C., Statello, R., Carnevali, L., Mancabelli, L., Milani, C., Mangifesta, M., . . . Turroni, F. (2017). How to feed the Mammalian gut microbiota: Bacterial and metabolic modulation by dietary fibers. Frontiers in Microbiology, 8(SEP), 1749.
Scopus73 Europe PMC602017 Bray, R., Cacciatore, S., Jiménez, B., Cartwright, R., Digesu, A., Fernando, R., . . . Khullar, V. (2017). Urinary Metabolic Phenotyping of Women with Lower Urinary Tract Symptoms. Journal of Proteome Research, 16(11), 4208-4216.
Scopus11 Europe PMC102016 Scientific Abstracts (2016). Reproductive Sciences, 23(1_suppl), 51A-344A.
2015 Jiménez, B. (2015). NMR-based metabolic phenotyping for disease diagnosis and stratification. eMagRes, 4(2), 269-276.
2015 Correia, G. D. S., Wooi Ng, K., Wijeyesekera, A., Gala-Peralta, S., Williams, R., Maccarthy-Morrogh, S., . . . Pathan, N. (2015). Metabolic profiling of children undergoing surgery for congenital heart disease. Critical Care Medicine, 43(7), 1467-1476.
Scopus43 Europe PMC342015 Powles, S. T. R., Hicks, L. C., Jiménez, B., Merrifield, C., Holmes, E., Williams, H. R. T., & Orchard, T. R. (2015). PTH-069 Effect of co-morbidities on urinary metabolic profiling in the characterisation of patients with inflammatory bowel disease. Gut, 64(Suppl 1), A436.2-A437.
2014 Mirnezami, R., Jiménez, B., Li, J. V., Kinross, J. M., Veselkov, K., Goldin, R. D., . . . Darzi, A. (2014). Rapid diagnosis and staging of colorectal cancer via high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy of intact tissue biopsies. Annals of Surgery, 259(6), 1138-1149.
Scopus70 Europe PMC502014 Dona, A. C., Jiménez, B., Schafer, H., Humpfer, E., Spraul, M., Lewis, M. R., . . . Nicholson, J. K. (2014). Precision high-throughput proton NMR spectroscopy of human urine, serum, and plasma for large-scale metabolic phenotyping. Analytical Chemistry, 86(19), 9887-9894.
Scopus410 Europe PMC3192013 Jiménez, B., Mirnezami, R., Kinross, J., Cloarec, O., Keun, H. C., Holmes, E., . . . Nicholson, J. K. (2013). <sup>1</sup>H HR-MAS NMR spectroscopy of tumor-induced local metabolic "field-effects" enables colorectal cancer staging and prognostication. Journal of Proteome Research, 12(2), 959-968.
Scopus111 Europe PMC812013 Kinross, J. M., Drymousis, P., Jiménez, B., & Frilling, A. (2013). Metabonomic profiling: A novel approach in neuroendocrine neoplasias. Surgery (United States), 154(6), 1185-1193.
Scopus26 Europe PMC202012 Wong, A., Jiménez, B., Li, X., Holmes, E., Nicholson, J. K., Lindon, J. C., & Sakellariou, D. (2012). Evaluation of high resolution magic-angle coil spinning NMR spectroscopy for metabolic profiling of nanoliter tissue biopsies. Analytical Chemistry, 84(8), 3843-3848.
Scopus39 Europe PMC182012 Gómez-Mingot, M., Alcaraz, L. A., MacIntyre, D. A., Jiménez, B., Pineda-Lucena, A., Montiel, V., . . . Iniesta, J. (2012). Development of a novel analytical approach combining the quantification of amino acids, organic acids and glucose using HPLC-UV-Vis and HPLC-MS with screening via NMR. Analytical Methods, 4(1), 284-290.
Scopus72012 Jiménez, B., Ugwu, F., Zhao, R., Ortí, L., Makhnevych, T., Pineda-Lucena, A., & Houry, W. A. (2012). Structure of minimal tetratricopeptide repeat domain protein Tah1 reveals mechanism of its interaction with Pih1 and Hsp90. Journal of Biological Chemistry, 287(8), 5698-5709.
Scopus43 Europe PMC402011 MacIntyre, D. A., Sanchís, D. M., Jiménez, B., Moreno, R., Stojkovic, M., & Pineda-Lucena, A. (2011). Characterisation of human embryonic stem cells conditioning media by <sup>1</sup>H-nuclear magnetic resonance spectroscopy. PLoS ONE, 6(2), 11 pages.
Scopus21 Europe PMC162010 Jiménez, B., Montoliu, C., MacIntyre, D. A., Serra, M. A., Wassel, A., Jover, M., . . . Felipo, V. (2010). Serum metabolic signature of minimal hepatic encephalopathy by <sup>1</sup>H-nuclear magnetic resonance. Journal of Proteome Research, 9(10), 5180-5187.
Scopus57 Europe PMC432010 MacIntyre, D. A., Jiménez, B., Lewintre, E. J., Martín, C. R., Schäfer, H., Ballesteros, C. G., . . . Pineda-Lucena, A. (2010). Serum metabolome analysis by <sup>1</sup>H-NMR reveals differences between chronic lymphocytic leukaemia molecular subgroups. Leukemia, 24(4), 788-797.
Scopus135 Europe PMC832008 Mori, M., Jiménez, B., Piccioli, M., Battistoni, A., & Sette, M. (2008). The solution structure of the monomeric copper, zinc superoxide dismutase from Salmonella enterica: Structural insights to understand the evolution toward the dimeric structure. Biochemistry, 47(49), 12954-12963.
Scopus16 Europe PMC112008 Bertini, I., Jiménez, B., Pierattelli, R., Wedd, A. G., & Xiao, Z. (2008). Protonless <sup>13</sup>C direct detection NMR: Characterization of the 37 kDa trimeric protein CutA1. Proteins: Structure, Function and Genetics, 70(4), 1196-1205.
Scopus13 Europe PMC62007 Jiménez, B., Mori, M., Battistoni, A., Sette, M., & Piccioli, M. (2007). NMR assignment of reduced form of copper, zinc superoxide dismutase from Salmonella enterica. Biomolecular NMR Assignments, 1(1), 65-67.
Scopus3 Europe PMC12006 Balayssac, S., Jiménez, B., & Piccioli, M. (2006). <sup>13</sup>C direct detected COCO-TOCSY: A tool for sequence specific assignment and structure determination in protonless NMR experiments. Journal of Magnetic Resonance, 182(2), 325-329.
Scopus7 Europe PMC52006 Balayssac, S., Jiménez, B., & Piccioli, M. (2006). Assignment strategy for fast relaxing signals: Complete aminoacid identification in thulium substituted calbindin D<inf>9K</inf>. Journal of Biomolecular NMR, 34(2), 63-73.
Scopus32 Europe PMC172005 Alcaraz, L. A., Jiménez, B., Moratal, J. M., & Donaire, A. (2005). An NMR view of the unfolding process of rusticyanin: Structural elements that maintain the architecture of a β-barrel metalloprotein. Protein Science, 14(7), 1710-1722.
Scopus11 Europe PMC92005 Bertini, I., Jiménez, B., & Piccioli, M. (2005). <sup>13</sup>C Direct detected experiments: Optimization for paramagnetic signals. Journal of Magnetic Resonance, 174(1), 125-132.
Scopus41 Europe PMC202005 Bertini, I., Jiménez, B., Piccioli, M., & Poggi, L. (2005). Asymmetry in<sup>13</sup>C-<sup>13</sup>C COSY spectra provides information on ligand geometry in paramagnetic proteins. Journal of the American Chemical Society, 127(35), 12216-12217.
Scopus20 Europe PMC72003 Jiménez, B., Piccioli, M., Moratal, J. M., & Donaire, A. (2003). Backbone dynamics of rusticyanin: The high hydrophobicity and rigidity of this blue copper protein is responsible for its thermodynamic properties. Biochemistry, 42(35), 10396-10405.
Scopus26 Europe PMC172003 Jiménez, B., Poggi, L., & Piccioli, M. (2003). Monitoring the Early Steps of Unfolding of Dicalcium and Mono-Ce <sup>3+</sup>-Substituted Forms of P43M Calbindin D<inf>9k</inf>. Biochemistry, 42(44), 13066-13073.
Scopus5 Europe PMC32002 Donaire, A., Jiménez, B., Fernández, C. O., Pierattelli, R., Niizeki, T., Moratal, J. M., . . . Vila, A. J. (2002). Metal-ligand interplay in blue copper proteins studied by <sup>1</sup>H NMR spectroscopy: Cu(II)-pseudoazurin and Cu(II)-rusticyanin. Journal of the American Chemical Society, 124(46), 13698-13708.
Scopus55 Europe PMC292001 Donaire, A., Jiménez, B., Moratal, J. M., Hall, J. F., & Hasnain, S. S. (2001). Electronic characterization of the oxidized state of the blue copper protein rusticyanin by <sup>1</sup>H NMR: Is the axial methionine the dominant influence for the high redox potential?. Biochemistry, 40(3), 837-846.
Scopus42 Europe PMC252001 Bertini, I., Donaire, A., Jiménez, B., Luchinat, C., Parigi, G., Piccioli, M., & Poggi, L. (2001). Paramagnetism-based versus classical constraints: An analysis of the solution structure of Ca Ln calbindin D<inf>9k</inf>. Journal of Biomolecular NMR, 21(2), 85-98.
Scopus100 Europe PMC59- doi:10.1021/bi034638
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Book Chapters
Year Citation 2017 Jiménez, B., & MacIntyre, D. (2017). NMR Metabolic Phenotyping in Clinical Studies. In Encyclopedia of Spectroscopy and Spectrometry (pp. 140-145). Elsevier.
DOI Scopus22004 Jiménez, B., Moratal, J. M., Piccioli, M., & Donaire, A. (2004). Mobility Studies in Proteins by 15N Nuclear Magnetic Resonance: Rusticyanin as an Example. In Principles and Practice (pp. 15-33). Springer Berlin Heidelberg.
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