Moustafa Mabrouk

Dr Moustafa Mabrouk

Postdoctoral Researcher, TI&I Program

South Australian Immunogenomics Cancer Institute

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.

Dr. Moustafa T. Mabrouk earned his PhD in Biomedical Engineering in 2024 from the University at Buffalo, New York. With a passion for integrating engineering principles with medical sciences, Dr. Mabrouk has dedicated his research to advancing healthcare technologies and improving patient outcomes.
During his doctoral studies, Dr. Mabrouk focused on developing innovative vaccine strategies for infectious diseases and cancer. His research developing a COVID-19 vaccine during the pandemic was published in Science Advances and highlighted by media has been recognized for its potential to develop a thermostable human vaccine.
In addition to his research, Dr. Mabrouk has actively contributed to the academic community. He has published over 20 peer-reviewed articles including five first authors and presented his findings at numerous international conferences such as ASTMH.
Dr. Mabrouk moved from USA to Australia to join SAiGENCI with the aspiration of developing a new cancer vaccine, leveraging his expertise in biomaterials and immunology. His interdisciplinary approach and collaborative spirit have allowed him to effectively engage with a diverse range of professionals, including engineers, scientists, and healthcare providers.

  • Education
    Date Institution name Country Title
    2020 - 2024 University at Buffalo, State University of New York United States PhD
    2018 - 2020 University at Buffalo, State University of New York United States MSc
    2016 - 2018 Alexandria University Egypt MSc
    2009 - 2014 Alexandria University Egypt PharmB

  • Journals
    Year Citation
    2024 Jiao, Y., Huang, W. C., Chiem, K., Song, Y., Sun, J., Chothe, S. K., . . . Lovell, J. F. (2024). SARS-CoV-2 Protein Nanoparticle Vaccines Formed In Situ From Lyophilized Lipids. Small, 20(9), 12 pages.
    DOI
    2023 Mabrouk, M. T., Zidan, A. A., Aly, N., Mohammed, M. T., Ghantous, F., Seaman, M. S., . . . Nasr, M. L. (2023). Circularized Nanodiscs for Multivalent Mosaic Display of SARS-CoV-2 Spike Protein Antigens. Vaccines, 11(11), 14 pages.
    DOI Scopus3 Europe PMC1
    2023 Zhou, S., Yu, K. O. A., Mabrouk, M. T., Jahagirdar, D., Huang, W. C., Guerra, J. A., . . . Lovell, J. F. (2023). Antibody induction in mice by liposome-displayed recombinant enterotoxigenic Escherichia coli (ETEC) colonization antigens. Biomedical Journal, 46(6), 100588.
    DOI Scopus6 Europe PMC3
    2022 McLeod, B., Mabrouk, M. T., Miura, K., Ravichandran, R., Kephart, S., Hailemariam, S., . . . Julien, J. P. (2022). Vaccination with a structure-based stabilized version of malarial antigen Pfs48/45 elicits ultra-potent transmission-blocking antibody responses. Immunity, 55(9), 1680-1692.e8.
    DOI Scopus29 Europe PMC21
    2022 Huang, W. C., Mabrouk, M. T., Zhou, L., Baba, M., Tachibana, M., Torii, M., . . . Lovell, J. F. (2022). Vaccine co-display of CSP and Pfs230 on liposomes targeting two Plasmodium falciparum differentiation stages. Communications Biology, 5(1), 773.
    DOI Scopus15 Europe PMC12
    2022 Sun, B., Ghosh, S., He, X., Huang, W. C., Quinn, B., Tian, M., . . . Lovell, J. F. (2022). Anti-cancer liposomal chemophototherapy using bilayer-localized photosensitizer and cabazitaxel. Nano Research, 15(5), 4302-4309.
    DOI Scopus13
    2022 Mabrouk, M. T., Huang, W. C., Martinez-Sobrido, L., & Lovell, J. F. (2022). Advanced Materials for SARS-CoV-2 Vaccines. Advanced Materials, 34(12), e2107781.
    DOI Scopus30 Europe PMC19
    2021 Mabrouk, M. T., Chiem, K., Rujas, E., Huang, W. C., Jahagirdar, D., Quinn, B., . . . Lovell, J. (2021). Lyophilized, thermostable Spike or RBD immunogenic liposomes induce protective immunity against SARS-CoV-2 in mice. Science Advances, 7(49), eabj1476.
    DOI Scopus30 Europe PMC17
    2021 Mabrouk, M. T., Zhang, H., Zidan, A. A., Kilian, H. I., Huang, W. C., Jahagirdar, D., . . . Lovell, J. F. (2021). Cross-linked Histone as a Nanocarrier for Gut Delivery of Hydrophobic Cargos. ACS Applied Materials and Interfaces, 13(23), 26712-26720.
    DOI Scopus7 Europe PMC1
    2021 He, X., Zhou, S., Huang, W. C., Seffouh, A., Mabrouk, M. T., Morgan, M. T., . . . Lovell, J. F. (2021). A Potent Cancer Vaccine Adjuvant System for Particleization of Short, Synthetic CD8<sup>+</sup>T Cell Epitopes. ACS Nano, 15(3), 4357-4371.
    DOI Scopus47 Europe PMC25
    2020 Huang, W. C., Zhou, S., He, X., Chiem, K., Mabrouk, M. T., Nissly, R. H., . . . Lovell, J. F. (2020). SARS-CoV-2 RBD Neutralizing Antibody Induction is Enhanced by Particulate Vaccination. Advanced Materials, 32(50), 11 pages.
    DOI Scopus75 Europe PMC55
    2020 Sun, B., Jing, H., Mabrouk, M. T., Zhang, Y., Jin, H., & Lovell, J. F. (2020). A surfactant-stripped cabazitaxel micelle formulation optimized with accelerated storage stability. Pharmaceutical Development and Technology, 25(10), 1281-1288.
    DOI Scopus10 Europe PMC3
    2020 Mabrouk, M. T., Huang, W. C., Deng, B., Li-Purcell, N., Seffouh, A., Ortega, J., . . . Lovell, J. F. (2020). Lyophilized, antigen-bound liposomes with reduced MPLA and enhanced thermostability. International Journal of Pharmaceutics, 589, 8 pages.
    DOI Scopus18 Europe PMC13
    2020 Huang, W. C., Deng, B., Mabrouk, M. T., Seffouh, A., Ortega, J., Long, C., . . . Lovell, J. F. (2020). Particle-based, Pfs230 and Pfs25 immunization is effective, but not improved by duplexing at fixed total antigen dose. Malaria Journal, 19(1), 12 pages.
    DOI Scopus19 Europe PMC17
    2019 Miranda, D., Wan, C., Kilian, H. I., Mabrouk, M. T., Zhou, Y., Jin, H., & Lovell, J. F. (2019). Indocyanine green binds to DOTAP liposomes for enhanced optical properties and tumor photoablation. Biomaterials Science, 7(8), 3158-3164.
    DOI Scopus37 Europe PMC16
    2018 Gaber, M., Mabrouk, M. T., Freag, M. S., Khiste, S. K., Fang, J. Y., Elkhodairy, K. A., & Elzoghby, A. O. (2018). Protein-polysaccharide nanohybrids: Hybridization techniques and drug delivery applications. European Journal of Pharmaceutics and Biopharmaceutics, 133, 42-62.
    DOI Scopus44 Europe PMC10
    2018 Abd Elwakil, M. M., Mabrouk, M. T., Helmy, M. W., Abdelfattah, E. Z. A., Khiste, S. K., Elkhodairy, K. A., & Elzoghby, A. O. (2018). Inhalable lactoferrin-chondroitin nanocomposites for combined delivery of doxorubicin and ellagic acid to lung carcinoma. Nanomedicine, 13(16), 2015-2035.
    DOI Scopus72 Europe PMC12
    2018 Abdelaziz, H. M., Gaber, M., Abd-Elwakil, M. M., Mabrouk, M. T., Elgohary, M. M., Kamel, N. M., . . . Elzoghby, A. O. (2018). Inhalable particulate drug delivery systems for lung cancer therapy: Nanoparticles, microparticles, nanocomposites and nanoaggregates. Journal of Controlled Release, 269, 374-392.
    DOI Scopus295 Europe PMC104
    2017 Sabra, S., Abdelmoneem, M., Abdelwakil, M., Mabrouk, M. T., Anwar, D., Mohamed, R., . . . Elzoghby, A. (2017). Self-assembled nanocarriers based on amphiphilic natural polymers for anti-cancer drug delivery applications. Current Pharmaceutical Design, 23(35), 5213-5229.
    DOI Scopus64 Europe PMC19
    2016 Elzoghby, A. O., Abd-Elwakil, M. M., Abd-Elsalam, K., Elsayed, M. T., Hashem, Y., & Mohamed, O. (2016). Natural polymeric nanoparticles for brain-targeting: Implications on drug and gene delivery. Current Pharmaceutical Design, 22(22), 3305-3323.
    DOI Scopus95 Europe PMC29

  • Current Higher Degree by Research Supervision (University of Adelaide)
    Date Role Research Topic Program Degree Type Student Load Student Name
    2024 Co-Supervisor Reprogramming Tumor-Associated Macrophages with mRNA Encapsulated Plant-Based Virus-like Nanoparticles for Immunotherapy of Triple Negative Breast Cancer Master of Philosophy (Medical Science) Master Full Time Miss Uta Ishikawa
  • Position: Postdoctoral Researcher, TI&I Program
  • Phone: 83134426
  • Email: moustafa.mabrouk@adelaide.edu.au
  • Campus: West End Health Precinct
  • Building: AHMS - Adelaide Health and Medical Sciences, floor Ninth Floor
  • Org Unit: South Australian Immunogenomics Cancer Institute
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