Ms Jaslene Anne Francis
Higher Degree by Research Candidate
School of Chemical Engineering
College of Engineering and Information Technology
Jaslene is currently a full-time PhD student at the School of Chemical Engineering, The University of Adelaide, Australia. She has extensive experience in drug binding studies which she obtained from her Bachelor’s and Master’s degree from the University of Malaya, Malaysia. She is currently the recipient of the Industry Doctoral Training Centre (IDTC) scholarship from the SA government, The University of Adelaide (PhD) with an industry partnership, BioCina.Jaslene's PhD project is on the 'Design of Ready-to-Inject Aqueous Formulations of mRNA-Lipid Nanoparticles'. In summary, perturbation of an aqueous environment and its effect on the transportation of materials by Lipid nanoparticle (LNP) is the bottleneck to understanding their interaction to support its successful transportation of mRNA. Although there was various interaction of therapeutic drugs and mRNA using LNP that have been previously studied, its stability over time has been challenging due to various exposure and condition. Therefore, understanding the interaction between mRNA-LNP and its basic excipients like water, salts, and tonicity modifiers in the aqueous environment may assist in demonstrating its potential carrier in an aqueous environment. These findings are expected to be obtained using the dynamic light scattering (DLS) technique to explain the interaction parameter between these elements and the surface of mRNA-LNP which is expected to contribute to a stable formulation at lower temperatures.
| Date | Position | Institution name |
|---|---|---|
| 2023 - 2023 | Research Intern | BioCina |
| 2021 - 2022 | Chemist | Top Glove International Berhad |
| 2018 - 2020 | Research Assistant | University of Malaya |
| Language | Competency |
|---|---|
| English | Can read, write, speak, understand spoken and peer review |
| Malay | Can read, write, speak, understand spoken and peer review |
| Tamil | Can read, write, speak and understand spoken |
| Date | Institution name | Country | Title |
|---|---|---|---|
| 2019 - 2021 | University of Malaya | Malaysia | Master of Science (Biochemistry) |
| 2014 - 2018 | University of Malaya | Malaysia | BSc Science (Biochemistry) |
| Date | Title | Institution name | Country |
|---|---|---|---|
| 2025 | Standard Mental Health First Aider | Mental Health First Aid Australia | - |
| Year | Citation |
|---|---|
| 2025 | Wright, L., Francis, J. A., Curtis, R., & Falconer, R. J. (2025). Dynamic Light Scattering Analysis of Lipid Nanoparticles: Effect of Salts on the Diffusion Interaction Parameter and Hydrodynamic Radius at Infinite Dilution.. Anal Chem, 97(4), 2437-2442. Scopus1 WoS1 Europe PMC1 |
| 2025 | Francis, J. A., Wright, L., van Wegen, R., Zhao, C. -X., & Falconer, R. J. (2025). Effects of salts, buffers and sucrose on protein-protein attractive and repulsive interactions.. International journal of pharmaceutics, 672, 125321. Scopus2 WoS2 Europe PMC2 |
| 2025 | Francis, J. A., Wright, L., Oerlemans, S. K., van Wegen, R., & Falconer, R. J. (2025). Idiosyncratic behaviour of pegylated lipid nanoparticles used in RNA delivery: A dynamic light scattering study.. Int J Pharm, 685, 126196. |
| 2024 | MUISA, K. A., FRANCIS, J. A., MOHAMAD, S. B., & TAYYAB, S. (2024). Elucidating the influence of some metal ions on the binding of antimalarial drugs to human serum albumin: spectroscopic approach. Revue Roumaine de Chimie, 68(10-12), 541-545. |
| 2020 | Francis, J. A., Shalauddin, M., Ridzwan, N. F. W., Mohamad, S. B., Basirun, W. J., & Tayyab, S. (2020). Interaction mechanism of an antimalarial drug, sulfadoxine with human serum albumin. SPECTROSCOPY LETTERS, 53(5), 391-405. WoS15 |
| 2019 | Tayyab, S., Francis, J. A., Kabir, M. Z., Ghani, H., & Mohamad, S. B. (2019). Probing the interaction of 2,4-dichlorophenoxyacetic acid with human serum albumin as studied by experimental and computational approaches. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 207, 284-293. WoS27 |