Yue Hui

Research Interests

Biomaterials Nanomedicine

Dr Yue Hui

NHMRC Externally-Funded Research Fellow

School of Chemical Engineering

College of Engineering and Information Technology

As an Investigator Grant recipient, I am an NHMRC EL1 fellow (2024-2028), and my research focuses on the development of advanced biomaterials for biomedical applications.

My current research primarily involves the development of hydrogel-based bioelectronics for reparing cardiac infarction, utilising soft matters (hydrogels), flexible electronics, and extrusion-based additive manufacturing (3D printing). I have developed materials and methods for embedded 3D printing to fabricate conductive hydrogels and hydrogel-based functional soft electronic devices for biomedical purposes such as signal sensing, electrical stimulating and tissue engineering.

I also have extensive experience in engineering nano- and micro-sized biomaterials for tumour-targeted drug delivery. I have developed nano-systems with adjustable mechanical properties (Young’s moduli) and have investigated how nanoparticle’s mechanical properties affect the interactions at the bio-nano interface. Currently, I am supervising PhD students working on the development of nano- and microparticle-based artificial antigen presenting cells (aAPCs) with varying stiffness for T cell activation for cancer immunotherapy.

Additionally, I possess experiece in microfluidics, organs-on-chips, and light-based 3D printing techniques.

Date Position Institution name
2024 - 2025 Research Fellow University of Adelaide
2022 - 2023 Postdoctoral Research Fellow University of Adelaide
2019 - 2021 Postdoctoral Research Fellow Westlake University
2019 - 2019 Senior Research Technician University of Queensland

Language Competency
Chinese (Mandarin) Can read, write, speak, understand spoken and peer review
English Can read, write, speak, understand spoken and peer review

Date Institution name Country Title
2014 - 2019 University of Queensland Australia PhD
2010 - 2014 Xi'an Jiaotong University China BEng

Year Citation
2026 Wang, X., Gu, Y., Luo, H., Nowak, C., Chen, R., Hui, Y., . . . Gersweller, L. (2026). Rapid, Scalable, and Cost-Effective Manufacturing of Uniform Non-Enveloped, Tag-Free Virus-Like Particles.. Curr Protoc, 6(2), e70309.
DOI WoS1
2026 Wang, X., Xu, L., Lan, Z., Hui, Y., Liu, Y., Yang, G., & Zhao, C. X. (2026). Advances in the Development of Lipid Nanoparticles for mRNA Delivery. Small Structures, 7(2).
DOI
2026 Wang, X., Gu, Y., Luo, H., Nowak, C., Chen, R., Hui, Y., . . . Gerstweiler, L. (2026). Correction: Rapid, Scalable, and Cost-Effective Manufacturing of Uniform Non-Enveloped, Tag-Free Virus-Like Particles (Current Protocols, (2026), 6, 2, 10.1002/cpz1.70309). Current Protocols, 6(2), e70343.
DOI
2025 Guo, Z., Li, Y., Xu, L., Wang, J., Lyu, J., Yang, G., . . . Zhao, C. -X. (2025). Design and optimization of bifunctional peptides for controlled core–shell nanocapsule formation. Journal of Colloid and Interface Science, 686, 599-612.
DOI Scopus3 WoS3 Europe PMC1
2025 Hou, F., Ranaweera, S., Li, X., Qiao, R., Hui, Y., & Zhao, C. (2025). A Universal Biomimetic Approach for Making Artificial Antigen‐Presenting Cells for T Cell Activation. Advanced Functional Materials, 35(40), 2504733-1-2504733-12.
DOI
2025 Zewail, M. B., Yang, G., Fan, Y., Hui, Y., Zhao, C., & Liu, Y. (2025). Cell Membrane‐Coated Lipid Nanoparticles for Drug Delivery. Aggregate, 6(7), e70054-1-e70054-45.
DOI Scopus16 WoS15
2025 Hou, F., Guo, Z., Hui, Y., & Zhao, C. (2025). Biomimetic Fabrication of Silica Microcapsules Using Bifunctional Peptides. Advanced Materials Interfaces, 12(15), e00221-1-e00221-10.
DOI Scopus1 WoS1
2025 Zhang, Y., Hui, Y., Guo, Z., Liu, D., Liu, Y., Gao, H., & Zhao, C. -X. (2025). Impact of Nanoparticle Stiffness on Endosomal Escape and Signaling Pathways in Cytosolic Delivery. Advanced Healthcare Materials, 14(28), 2501706-1-2501706-15.
DOI Scopus3 WoS2
2025 Yang, G., Liu, Y., Devkota, S. R., Hui, Y., Zhao, R., Li, Y., . . . Zhao, C. (2025). A Sustainable Biotechnology Approach for Mineral Separation. Advanced Functional Materials, 35(50), e04992-1-e04992-16.
DOI
2024 Hou, F., Guo, Z., Ho, M. T., Hui, Y., & Zhao, C. -X. (2024). Particle-Based Artificial Antigen-Presenting Cell Systems for T Cell Activation in Adoptive T Cell Therapy. ACS Nano, 18(12), 8571-8599.
DOI Scopus27 WoS25 Europe PMC18
2024 Weng, Y., Chen, R., Hui, Y., Chen, D., & Zhao, C. -X. (2024). Boosting Enzyme Activity in Enzyme Metal-Organic Framework Composites. Chem & Bio Engineering, 1(2), 99-112.
DOI Scopus49 WoS46 Europe PMC22
2024 Li, Y., Weng, Y., Hui, Y., Wang, J., Xu, L., Yang, Y., . . . Zhao, C. -X. (2024). Design of stimuli-responsive minimalist heptad surfactants for stable emulsions. Communications Materials, 5(1), 229-1-229-11.
DOI Scopus1 WoS1 Europe PMC1
2024 Hui, Y., Liu, Y., Yang, G., Weng, Y., Hou, F., Wang, X., . . . Zhao, C. -X. (2024). Critical Role of Nanomaterial Mechanical Properties in Drug Delivery, Nanovaccines and Beyond. Advanced Materials, 37(7), 2413779-1-2413779-37.
DOI Scopus17 WoS17 Europe PMC12
2023 Yang, G., Liu, Y., Jin, S., Hui, Y., Wang, X., Xu, L., . . . Zhao, C. (2023). Phase separation‐induced nanoprecipitation for making polymer nanoparticles with high drug loading. Aggregate, 4(2), e314-1-e314-9.
DOI Scopus31 WoS30
2023 Yao, Y., Hui, Y., Wang, Z., Chen, H., Zhu, H., & Zhou, N. (2023). Granular Ionogel Particle Inks for 3D Printed Tough and Stretchable Ionotronics.. Research (Washington, D.C.), 6, 14 pages.
DOI Scopus17 WoS19 Europe PMC6
2023 Chen, H., Wang, J., Peng, S., Liu, D., Yan, W., Shang, X., . . . Zhou, N. (2023). A Generalized Polymer Precursor Ink Design for 3D Printing of Functional Metal Oxides.. Nano-micro letters, 15(1), 1-16.
DOI Scopus14 WoS12 Europe PMC5
2022 Tengjisi., Hui, Y., Fan, Y., Zou, D., Talbo, G. H., Yang, G., & Zhao, C. X. (2022). Influence of nanoparticle mechanical property on protein corona formation. Journal of Colloid and Interface Science, 606(2), 1737-1744.
DOI Scopus41 WoS34 Europe PMC30
2022 Liu, Y., Yang, G., Hui, Y., Ranaweera, S., & Zhao, C. -X. (2022). Microfluidic Nanoparticles for Drug Delivery. Small, 18(36), 33 pages.
DOI Scopus253 WoS225 Europe PMC114
2022 Chen, H., Min, X., Hui, Y., Qin, W., Zhang, B., Yao, Y., . . . Zhou, N. (2022). Colloidal oxide nanoparticle inks for micrometer-resolution additive manufacturing of three-dimensional gas sensors. Materials Horizons, 9(2), 764-771.
DOI Scopus13 WoS13 Europe PMC9
2022 Zhang, H., Yao, Y., Hui, Y., Zhang, L., Zhou, N., & Ju, F. (2022). A 3D-printed microfluidic gradient concentration chip for rapid antibiotic-susceptibility testing. Bio-Design and Manufacturing, 5(1), 210-219.
DOI Scopus25 WoS25
2022 Hui, Y., Yao, Y., Qian, Q., Luo, J., Chen, H., Qiao, Z., . . . Zhou, N. (2022). Three-dimensional printing of soft hydrogel electronics. Nature Electronics, 5(12), 893-903.
DOI Scopus196 WoS192
2022 Zou, D., Wu, Z., Yi, X., Hui, Y., Yang, G., Liu, Y., . . . Zhao, C. -X. (2022). Nanoparticle elasticity regulates the formation of cell membrane-coated nanoparticles and their nano-bio interactions. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 120(1), 1-12.
DOI Scopus67 WoS74 Europe PMC56
2021 Wilson, R. J., Hui, Y., Whittaker, A. K., & Zhao, C. X. (2021). Facile bioinspired synthesis of iron oxide encapsulating silica nanocapsules. Journal of Colloid and Interface Science, 601, 78-84.
DOI Scopus24 WoS20 Europe PMC15
2021 Yang, G., Liu, Y., Hui, Y., Tengjisi., Chen, D., Weitz, D. A., & Zhao, C. X. (2021). Implications of Quenching-to-Dequenching Switch in Quantitative Cell Uptake and Biodistribution of Dye-Labeled Nanoparticles. Angewandte Chemie - International Edition, 60(28), 15426-15435.
DOI Scopus20 WoS19
2021 Tengjisi., Hui, Y., Yang, G., Fu, C., Liu, Y., & Zhao, C. X. (2021). Biomimetic core–shell silica nanoparticles using a dual-functional peptide. Journal of Colloid and Interface Science, 581(A), 185-194.
DOI Scopus25 WoS17 Europe PMC11
2020 Zou, D., Yu, L., Sun, Q., Hui, Y., Tengjisi., Liu, Y., . . . Zhao, C. X. (2020). A general approach for biomimetic mineralization of MOF particles using biomolecules. Colloids and Surfaces B: Biointerfaces, 193, 1-9.
DOI Scopus48 WoS45 Europe PMC25
2020 Zou, D., Yu, L., Sun, Q., Hui, Y., Jisi, T., Liu, Y., . . . Zhao, C. -X. (2020). A General Approach for Encapsulation of Biomolecules Using MOF Particles.
DOI
2020 Liu, Y., Yang, G., Zou, D., Hui, Y., Nigam, K., Middelberg, A. P. J., & Zhao, C. X. (2020). Formulation of nanoparticles using mixing-induced nanoprecipitation for drug delivery. Industrial and Engineering Chemistry Research, 59(9), 4134-4149.
DOI Scopus181 WoS156
2020 Hui, Y., Yi, X., Wibowo, D., Yang, G., Middelberg, A. P. J., Gao, H., & Zhao, C. X. (2020). Nanoparticle elasticity regulates phagocytosis and cancer cell uptake. Science Advances, 6(16), 1-11.
DOI Scopus224 WoS212 Europe PMC157
2019 Hui, Y., Yi, X., Hou, F., Wibowo, D., Zhang, F., Zhao, D., . . . Zhao, C. X. (2019). Role of nanoparticle mechanical properties in cancer drug delivery. ACS Nano, 13(7), 7410-7424.
DOI Scopus343 WoS322 Europe PMC210
2019 Ran, R., Wang, H. F., Hou, F., Liu, Y., Hui, Y., Petrovsky, N., . . . Zhao, C. X. (2019). A microfluidic tumor-on-a-chip for assessing multifunctional liposomes' tumor targeting and anticancer efficacy. Advanced Healthcare Materials, 8(8), 1-10.
DOI Scopus62 WoS59 Europe PMC43
2019 Yu, L., Sun, Q., Hui, Y., Seth, A., Petrovsky, N., & Zhao, C. X. (2019). Microfluidic formation of core-shell alginate microparticles for protein encapsulation and controlled release. Journal of Colloid and Interface Science, 539, 497-503.
DOI Scopus139 WoS125 Europe PMC66
2019 Peters, B. C., Wibowo, D., Yang, G. Z., Hui, Y., Middelberg, A. P. J., & Zhao, C. X. (2019). Evaluation of baiting fipronil-loaded silica nanocapsules against termite colonies in fields. Heliyon, 5(8), e02277-1-e02277-10.
DOI Scopus19 WoS10 Europe PMC6
2019 Yang, G., Liu, Y., Wang, H., Wilson, R., Hui, Y., Yu, L., . . . Zhao, C. X. (2019). Bioinspired core-shell nanoparticles for hydrophobic drug delivery. Angewandte Chemie - International Edition, 58(40), 14357-14364.
DOI Scopus117 WoS110 Europe PMC65
2018 Hui, Y., Wibowo, D., Liu, Y., Ran, R., Wang, H., Seth, A., . . . Zhao, C. (2018). Understanding the effects of nanocapsular mechanical property on passive and active tumor targeting. ACS Nano, 12(3), 2846-2857.
DOI Scopus162 WoS154 Europe PMC108
2018 Liu, Y., Hui, Y., Ran, R., Yang, G. Z., Wibowo, D., Wang, H. F., . . . Zhao, C. X. (2018). Synergetic combinations of dual-targeting ligands for enhanced in vitro and in vivo tumor targeting. Advanced Healthcare Materials, 7(15), 1800106-1-1800106-11.
DOI Scopus60 WoS56 Europe PMC36
2018 Ran, R., Wang, H., Liu, Y., Hui, Y., Sun, Q., Seth, A., . . . Zhao, C. X. (2018). Microfluidic self-assembly of a combinatorial library of single- and dual-ligand liposomes for in vitro and in vivo tumor targeting. European Journal of Pharmaceutics and Biopharmaceutics, 130, 1-10.
DOI Scopus68 WoS63 Europe PMC40
2018 Wang, H. F., Ran, R., Liu, Y., Hui, Y., Zeng, B., Chen, D., . . . Zhao, C. X. (2018). Tumor-Vasculature-on-a-Chip for Investigating Nanoparticle Extravasation and Tumor Accumulation. ACS Nano, 12(11), 11600-11609.
DOI Scopus139 WoS136 Europe PMC106
2018 Sun, Q., Tan, S. H., Chen, Q., Ran, R., Hui, Y., Chen, D., & Zhao, C. X. (2018). Microfluidic Formation of Coculture Tumor Spheroids with Stromal Cells As a Novel 3D Tumor Model for Drug Testing. ACS Biomaterials Science and Engineering, 4(12), 4425-4433.
DOI Scopus90 WoS87 Europe PMC58
2017 Zhao, C., Chen, D., Hui, Y., Weitz, D., & Middelberg, A. (2017). Controlled generation of ultrathin-shell double emulsions and studies on their stability. ChemPhysChem, 18(10), 1393-1399.
DOI Scopus30 WoS30 Europe PMC13
2016 Wibowo, D., Hui, Y., Middelberg, A., & Zhao, C. (2016). Interfacial engineering for silica nanocapsules. Advances in Colloid and Interface Science, 236, 83-100.
DOI Scopus45 WoS45 Europe PMC22
2016 Zhao, C., Chen, D., Hui, Y., Weitz, D., & Middelberg, A. (2016). Stable ultrathin-shell double emulsions for controlled release. ChemPhysChem, 17(11), 1553-1556.
DOI Scopus28 WoS29 Europe PMC14
2016 Hui, Y., Wibowo, D., & Zhao, C. X. (2016). Insights into the Role of Biomineralizing Peptide Surfactants on Making Nanoemulsion-Templated Silica Nanocapsules. Langmuir, 32(3), 822-830.
DOI Scopus22 WoS21 Europe PMC11

Year Citation
- Hui, Y. (n.d.). Bio-inspired silica nanocapsules for understanding in vitro and in vivo nano-bio interactions.

Year Citation
2022 Hui, Y., Qian, Q., Yao, Y., Chen, H., Qiao, Z., Yu, Y., & Zhou, N. (2022). Freeform 3D Printing of Soft Hydrogel Electronics.
DOI
  1. AEA Seed grant: AU$ 299K, 2024-2025, leading CI.
  2. NHMRC Investigator Grant (EL1): AU$ 662K, 2024-2028, Sole CI.
  3. Westlake University postdoc research grant: Approx. AU$ 20K, 2019-2021, Sole CI.

Date Role Research Topic Program Degree Type Student Load Student Name
2026 Co-Supervisor Development of novel microfluidic devices for making mRNA nanomedicines Doctor of Philosophy Doctorate Full Time Miss Qian Wu
2025 Principal Supervisor Harnessing Systemic Immunity for Next-Generation Cancer Immunotherapy Doctor of Philosophy Doctorate Full Time Miss Qian Wang
2025 Principal Supervisor Harnessing Systemic Immunity for Next-Generation Cancer Immunotherapy Doctor of Philosophy Doctorate Full Time Ms Qian Wang
2024 Principal Supervisor Development of anti-swelling hydrogels for next-generation soft electronics Doctor of Philosophy Doctorate Full Time Mr Geng Yang
2024 Principal Supervisor Development of integrated microfluidic chips for making mRNA nanomedicines Doctor of Philosophy Doctorate Full Time Vincent Patrick Linden
2024 Principal Supervisor Development of conductive hydrogels for biomedical applications Doctor of Philosophy Doctorate Full Time Ms Zilin Ye
2024 Principal Supervisor Development of anti-swelling hydrogels for next-generation soft electronics Doctor of Philosophy Doctorate Full Time Mr Geng Yang
2024 Principal Supervisor Development of integrated microfluidic chips for making mRNA nanomedicines Doctor of Philosophy Doctorate Full Time Mr Vincent Patrick Linden
2024 Principal Supervisor Development of conductive hydrogels for biomedical applications Doctor of Philosophy Doctorate Full Time Ms Zilin Ye
2023 Co-Supervisor Development of Cancer-on-a-Chip Platforms for Drug Screening Doctor of Philosophy Doctorate Full Time Mr Max George Higham
2023 Co-Supervisor Development of Cancer-on-a-Chip Platforms for Drug Screening Doctor of Philosophy Doctorate Full Time Mr Max George Higham
2022 Co-Supervisor Effects of mechanical properties of precision-engineered nanoscale aAPCs on T cell activation and expansion Doctor of Philosophy Doctorate Full Time Mr Zichao Guo
2022 Co-Supervisor Development of mRNA loaded Lipid Nanoparticles for CAR T Cell Therapy Doctor of Philosophy Doctorate Full Time Ms Minh Trang Ho
2022 Co-Supervisor Development of mRNA loaded Lipid Nanoparticles for CAR T Cell Therapy Doctor of Philosophy Doctorate Full Time Ms Minh Trang Ho
2022 Co-Supervisor Effects of mechanical properties of precision-engineered nanoscale aAPCs on T cell activation and expansion Doctor of Philosophy Doctorate Full Time Mr Zichao Guo

Date Role Research Topic Program Degree Type Student Load Student Name
2022 - 2025 Co-Supervisor Engineering Microparticle-based Artificial Antigen Presenting Cells for T-cell Activation in Immunotherapy Doctor of Philosophy Doctorate Full Time Mr Fei Hou
2022 - 2025 Co-Supervisor New approaches for enhancing T cell activation for cancer immunotherapy. Doctor of Philosophy Doctorate Full Time Dr Supun Akash Ranaweera
2022 - 2025 Co-Supervisor Engineering and Evaluation of Lipid-Based Nanoparticles for mRNA Delivery Doctor of Philosophy Doctorate Full Time Mr Xing Wang

Date Topic Location Name
2020 - 2021 A 3D-printed microfluidic gradient concentration chip for rapid antibiotic-susceptibility testing Westlake University Huilin Zhang
2020 - 2021 Colloidal oxide nanoparticle inks for micrometer-resolution additive manufacturing of three-dimensional gas sensors Westlake University Hehao Chen
2020 - 2020 3D printing of soft hydrogel electronics Westlake University Zheng Qiao
2018 - 2018 Impact of nanoparticle stiffness in cancer drug delivery The University of Queensland Fei Hou
2018 - 2018 Impact of nanoparticle stiffness in cancer drug delivery The University of Queensland Mingxuan Wan

Date Role Membership Country
2017 - ongoing Member The Australian Nanotechnology Network Australia

Date Title Engagement Type Institution Country
2020 - 2021 Member of Postdoc Committee Public Community Engagement Westlake University -

Date Event Name Event Type Institution Country
2022 - 2022 2022 Exploration Australian Multidisciplinary Webinar Conference 2022 Australian Australian Multidisciplinary Webinar Australia

Date Title Type Institution Country
2023 - ongoing Aggregate Journal Review The University of Adelaide -
2022 - ongoing Examine MPhil thesis Thesis Review The University of Adelaide Australia
2021 - ongoing MethodsX Journal Review Westlake University -

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