Braden Rose

My research focuses on understanding the role intestinal sweet sensing plays in controlling blood glucose. I currently lead multiple projects spanning pre-clinical research using genetic mouse models, basic laboratory experiments on ex vivo human tissues, and interventional clinical studies with the aim of finding new ways to treat type 2 diabetes. 

RESEARCH PROJECTS AVAILABLE (2025 – 2026):

Blocking intestinal sweet taste for glycaemic benefits in type 2 diabetes (Honours)

We know that intestinal sweet sensing is dysregulated in people who have type 2 diabetes, and that this results in increased intestinal glucose absorption compared to health. However, the potential targeting of glucose absorption in diabetes to better control blood glucose after eating is under-explored. This interventional clinical project will investigate whether blocking sweet sensing in the intestine can improve blood glucose control in people with type 2 diabetes. 

Supervisors: Dr Braden Rose, A/Prof Richard Young

Degree: Honours

Location: SAHMRI and AHMS, North Terrace

Skills learned: Clinical - taking blood, dietary analysis, data entry. Laboratory– human tissue processing, plasma hormone measurement. General – literature searching, statistical analysis, data interpretation, increased knowledge on blood glucose control and type 2 diabetes. 

What role does intestinal sweet sensing play in blood glucose control?

This project will utilise our novel genetic mouse models to determine the precise mechanisms that link sweet sensing in the intestinal wall to glucose absorption and gut hormone responses, and how this affects blood glucose control and the progression of type 2 diabetes. This project may also involve functional and multiomic experiments in collected human biopsy and other tissues, as well as experiments investigating effects on the gut microbiome. These mouse and laboratory experiments will be carried out in SAHMRI and can be modified to better suit a one-year honours project.  

Supervisors: Dr Braden Rose, A/Prof Richard Young

Degree: PhD, Honours

Location:  SAHMRI, North Terrace

Skills learned: Laboratory – mouse experimental skills, tissue processing, cryopreservation, basic lab techniques (PCR, ELISA, IHC). General - literature searching, statistical analysis, data interpretation, increased knowledge on blood glucose control and type 2 diabetes.