Benjamin Kile

School of Biomedicine

Faculty of Health and Medical Sciences

Ben is Executive Director of the Garvan Institute of Medical Research. His PhD was conducted at the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia, under the supervision of Professors Warren Alexander and Douglas Hilton. Graduating in 2001, Ben pursued postdoctoral studies with Professor Monica Justice at Baylor College of Medicine, Houston, USA. In 2004 he returned to the Walter and Eliza Hall Institute, joining the faculty in 2005, and being appointed an independent laboratory head in 2008. After jointly leading the institute's ACRF Chemical Biology Division from 2014-2017, Ben took up the position of Head, Department of Anatomy and Developmental Biology, within the Biomedicine Discovery Institute at Monash University. In October 2019 he moved to the University of Adelaide.

My Research
Career
Publications
Grants and Funding
Contact

The Kile lab's research has focused primarily on the molecular regulation of blood cell formation and function, at steady state, and in disease settings such as inflammation and leukemia. We have a deep interest in the role programmed cell death pathways play in these processes, and how the cell death machinery mediates the response to pathophysiological insults such as cancer chemotherapy. Our work has contributed to understanding the survival of platelets – the tiny cells that mediate blood clotting – and informed the clinical development of a new class of cancer drugs called the BH3 mimetics. We have identified critical roles for the cell death machinery in suppressing innate immune signalling, suggesting new therapeutic approaches to the treatment of viral infections and cancer.

Appointments

Date	Position	Institution name
2019 - ongoing	Executive Dean	Faculty of Health and Medical Sciences
2017 - 2019	Head, Department of Anatomy and Developmental Biology	Monash University
2014 - 2017	Head, ACRF Chemical Biology Division	Walter and Eliza Hall Institute of Medical Research
2012 - ongoing	Board Member	Australian Genomics Research Facility
2008 - 2013	Laboratory Head	Walter and Eliza Hall Institute of Medical Research

Education

Date	Institution name	Country	Title
2001	University of Melbourne	Australia	PhD
1997	University of Melbourne	Australia	BSc(Hons)
1995	Monash University	Australia	LLB
1993	Monash University	Australia	BSc

Research Interests

Cancer Biology and Clinical Oncology Immunology and Infection Animal Cell and Molecular Biology Biochemistry and Cell Biology Cancer Cell Biology Cardiovascular System & Hematology Cell Development, Proliferation and Death Chemotherapy

Journals

Year	Citation
2025	Li, K., Yap, Y. Q., Moujalled, D. M., Sumardy, F., Khakham, Y., Georgiou, A., . . . Lessene, G. (2025). Differential regulation of BAX and BAK apoptotic activity revealed by small molecules. Science Advances, 11(10), eadr8146-1-eadr8146-14. DOI Scopus2 WoS2 Europe PMC2
2024	Thilakasiri, P., O'Keefe, R. N., To, S. Q., Chisanga, D., Eissmann, M. F., Carli, A. L., . . . Chand, A. L. (2024). Mechanisms of cellular crosstalk in the gastric tumor microenvironment are mediated by YAP1 and STAT3. Life Science Alliance, 7(2), e202302411-1-e202302411-17. DOI Scopus1 WoS2 Europe PMC1
2024	El-Mortada, F., Landelouci, K., Bertrand-Perron, S., Aubé, F. A., Poirier, A., Bidias, A., . . . Pépin, G. (2024). Megakaryocytes possess a STING pathway that is transferred to platelets to potentiate activation. Life Science Alliance, 7(2), 11 pages. DOI Scopus4 WoS4 Europe PMC4
2024	Saunders, T. L., Windley, S. P., Gervinskas, G., Balka, K. R., Rowe, C., Lane, R., . . . McArthur, K. (2024). Exposure of the inner mitochondrial membrane triggers apoptotic mitophagy. Cell Death and Differentiation, 31(3), 335-347. DOI Scopus24 WoS20 Europe PMC15
2024	McArthur, K., & Kile, B. T. (2024). mtDNA caught in the act again. Nature Cell Biology, 26(2), 177-178. DOI Scopus1 WoS1 Europe PMC1
2024	Tran, S., Juliani, J., Harris, T. J., Evangelista, M., Ratcliffe, J., Ellis, S. L., . . . Lee, E. F. (2024). BECLIN1 is essential for intestinal homeostasis involving autophagy-independent mechanisms through its function in endocytic trafficking. Communications Biology, 7(1), 209-1-209-13. DOI Scopus8 WoS8 Europe PMC7
2024	Murray, J. E., Valli, E., Milazzo, G., Mayoh, C., Gifford, A. J., Fletcher, J. I., . . . Norris, M. D. (2024). The transcriptional co-repressor Runx1t1 is essential for MYCN-driven neuroblastoma tumorigenesis. Nature Communications, 15(1), 5585-1-5585-21. DOI Scopus4 WoS3 Europe PMC5
2024	Cheung, B. B., Mittra, R., Murray, J., Wang, Q., Seneviratne, J. A., Raipuria, M., . . . Marshall, G. M. (2024). Golgi-localized Ring Finger Protein 121 is necessary for MYCN-driven neuroblastoma tumorigenesis. Communications Biology, 7(1), 1322-1-1322-13. DOI
2024	Venkatraman, R., Balka, K. R., Wong, W., Sivamani, J., Magill, Z., Tullett, K. M., . . . De Nardo, D. (2024). IKKɛ induces STING non-IFN immune responses via a mechanism analogous to TBK1. iScience, 27(9), 110693-1-110693-24. DOI Scopus4 WoS4 Europe PMC3
2023	Heazlewood, S. Y., Ahmad, T., Cao, B., Cao, H., Domingues, M., Sun, X., . . . Nilsson, S. K. (2023). High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production. Nature communications, 14(1), 18 pages. DOI Scopus22 WoS20 Europe PMC22
2023	Balka, K. R., Venkatraman, R., Saunders, T. L., Shoppee, A., Pang, E. S., Magill, Z., . . . De Nardo, D. (2023). Termination of STING responses is mediated via ESCRT-dependent degradation. EMBO Journal, 42(12), e112712-1-e112712-21. DOI Scopus43 WoS42 Europe PMC36
2023	Ullah, T. R., Johansen, M. D., Balka, K. R., Ambrose, R. L., Gearing, L. J., Roest, J., . . . Gantier, M. P. (2023). Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection. Nature Communications, 14(1), 1-13. DOI Scopus8 WoS7 Europe PMC10
2023	Richman, T. R., Ermer, J. A., Baker, J., Siira, S. J., Kile, B. T., Linden, M. D., . . . Filipovska, A. (2023). Mitochondrial gene expression is required for platelet function and blood clotting. Cell Reports, 42(11), 113312-1-113312-19. DOI Scopus12 WoS11 Europe PMC7
2022	Davidson, S., Yu, C. -H., Steiner, A., Ebstein, F., Baker, P. J., Jarur-Chamy, V., . . . Masters, S. L. (2022). Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24. Science Immunology, 7(68), eabi6763-1-eabi6763-?. DOI Scopus45 WoS43 Europe PMC45
2022	Pang, E. S., Daraj, G., Balka, K. R., De Nardo, D., Macri, C., Hochrein, H., . . . O'Keeffe, M. (2022). Discordance in STING-Induced Activation and Cell Death Between Mouse and Human Dendritic Cell Populations. Frontiers in immunology, 13, 794776-1-794776-19. DOI Scopus17 WoS17 Europe PMC15
2022	Salmon, J. M., Todorovski, I., Stanley, K. L., Bruedigam, C., Kearney, C. J., Martelotto, L. G., . . . Johnstone, R. W. (2022). Epigenetic activation of plasmacytoid DC drives IFNAR-dependent therapeutic differentiation of AML. Cancer Discovery, 12(6), 1560-1579. DOI Scopus26 WoS24 Europe PMC22
2021	Lee, M. K. S., Kraakman, M. J., Dragoljevic, D., Hanssen, N. M. J., Flynn, M. C., Al-Sharea, A., . . . Murphy, A. J. (2021). Apoptotic ablation of platelets reduces atherosclerosis in mice with diabetes. Arteriosclerosis, Thrombosis and Vascular Biology, 41(3), 1167-1178. DOI Scopus16 WoS14 Europe PMC12
2021	Chappaz, S., Saunders, T. L., & Kile, B. T. (2021). Generation of murine bone marrow and fetal liver chimeras. Current Protocols, 1(4), e79-1-e79-20. DOI Scopus1 WoS1 Europe PMC1
2021	Strassel, C., Magiera, M. M., Dupuis, A., Batzenschlager, M., Hovasse, A., Pleines, I., . . . Lanza, F. (2021). Correction: An essential role for α4A-tubulin in platelet biogenesis.. Life science alliance, 4(8), e202101132. DOI WoS1
2021	Chappaz, S., McArthur, K., Kealy, L., Law, C. W., Tailler, M., Lane, R. M., . . . Kile, B. T. (2021). Homeostatic apoptosis prevents competition-induced atrophy in follicular B cells. Cell Reports, 36(3), 1-7. DOI Scopus5 WoS5 Europe PMC6
2021	Ngo, S., Oxley, E. P., Ghisi, M., Garwood, M. M., McKenzie, M. D., Mitchell, H. L., . . . Dickins, R. A. (2021). Acute myeloid leukemia maturation lineage influences residual disease and relapse following differentiation therapy. Nature Communications, 12(1), 6546-1-6546-14. DOI Scopus10 WoS8 Europe PMC5
2020	Pépin, G., De Nardo, D., Rootes, C. L., Ullah, T. R., Al-Asmari, S. S., Balka, K. R., . . . Gantier, M. P. (2020). Connexin-dependent transfer of cgamp to phagocytes modulates antiviral responses. mBio, 11(1), 1-6. DOI Scopus57 WoS56 Europe PMC44
2020	Denorme, F., Manne, B. K., Portier, I., Eustes, A. S., Kosaka, Y., Kile, B. T., . . . Campbell, R. A. (2020). Platelet necrosis mediates ischemic stroke outcome in mice. Blood, 135(6), 429-440. DOI Scopus81 WoS79 Europe PMC70
2020	Balka, K. R., Louis, C., Saunders, T. L., Smith, A. M., Calleja, D. J., D'Silva, D. B., . . . De Nardo, D. (2020). TBK1 and IKKε act redundantly to mediate STING-induced NF-κB responses in myeloid cells. Cell Reports, 31(1), 107492-1-107492-22. DOI Scopus317 WoS313 Europe PMC254
2020	Chappaz, S., Law, C. W., Dowling, M. R., Carey, K. T., Lane, R. M., Ngo, L. H., . . . Kile, B. T. (2020). Germline heterozygous mutations in Nxf1 perturb RNA metabolism and trigger thrombocytopenia and lymphopenia in mice. Blood Advances, 4(7), 1270-1283. DOI Scopus6 WoS6 Europe PMC5
2020	Hildebrand, J. M., Kauppi, M., Majewski, I. J., Liu, Z., Cox, A. J., Miyake, S., . . . Silke, J. (2020). A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction. Nature Communications, 11(1), 3150. DOI Scopus75 WoS75 Europe PMC74
2020	Fagnan, A., Bagger, F. O., Piqué-Borràs, M. R., Ignacimouttou, C., Caulier, A., Lopez, C. K., . . . Mercher, T. (2020). Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers. Blood, 136(6), 698-714. DOI Scopus34 WoS34 Europe PMC32
2020	Deo, P., Chow, S. H., Han, M. L., Speir, M., Huang, C., Schittenhelm, R. B., . . . Naderer, T. (2020). Mitochondrial dysfunction caused by outer membrane vesicles from Gram-negative bacteria activates intrinsic apoptosis and inflammation. Nature Microbiology, 5(11), 1418-1427. DOI Scopus167 WoS157 Europe PMC136
2020	Carmichael, C. L., Wang, J., Nguyen, T., Kolawole, O., Benyoucef, A., De Mazière, C., . . . Haigh, J. J. (2020). The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1. Blood, 136(8), 957-973. DOI Scopus44 WoS42 Europe PMC35
2020	Denorme, F., Manne, B. K., Portier, I., Petrey, A. C., Middleton, E., Kile, B. T., . . . Campbell, R. A. (2020). COVID-19 patients exhibit reduced procoagulant platelet responses. Journal of thrombosis and haemostasis : JTH, 18(11), 3067-3073. DOI Scopus59 WoS55 Europe PMC53
2020	McArthur, K., & Kile, B. T. (2020). Apoptotic mitochondria prime anti-tumour immunity. Cell Death Discovery, 6(1), 3 pages. DOI Scopus12 WoS12 Europe PMC10
2020	Salmon, J., Todorovski, I., Vervoort, S., Stanley, K., Kearney, C., Martelotto, L., . . . Johnstone, R. (2020). Epigenetic reprogramming of plasmacytoid dendritic cells drives type I interferon-dependent differentiation of acute myeloid leukemias for therapeutic benefit. DOI
2019	Strassel, C., Magiera, M. M., Dupuis, A., Batzenschlager, M., Hovasse, A., Pleines, I., . . . Lanza, F. (2019). An essential role for α4A-tubulin in platelet biogenesis. Life Science Alliance, 2(1), e201900309-1-e201900309-13. DOI Scopus43 WoS39 Europe PMC28
2019	Hildebrand, J., Kauppi, M., Majewski, I., Liu, Z., Cox, A., Miyake, S., . . . Silke, J. (2019). Missense mutations in the MLKL ‘brace’ region lead to lethal neonatal inflammation in mice and are present in high frequency in humans. DOI
2019	Walkley, C. R., & Kile, B. T. (2019). Cell death following the loss of ADAR1 mediated A-to-I RNA editing is not effected by the intrinsic apoptosis pathway. Cell Death and Disease, 10(12), 913. DOI Scopus14 WoS11 Europe PMC12
2019	Iacobucci, I., Wen, J., Meggendorfer, M., Choi, J. K., Shi, L., Pounds, S. B., . . . Mullighan, C. G. (2019). Genomic subtyping and therapeutic targeting of acute erythroleukemia. Nature genetics, 51(4), 694-704. DOI Scopus120 WoS119 Europe PMC105
2019	Chiu, S. K., Orive, S. L., Moon, M. J., Saw, J., Ellis, S., Kile, B. T., . . . Curtis, D. J. (2019). Shared roles for Scl and Lyl1 in murine platelet production and function. Blood, 134(10), 826-835. DOI Scopus14 WoS14 Europe PMC12
2019	Levin, J., & Kile, B. (2019). Acknowledgements: the Levin/Kile rule. Platelets, 30(2), 280. DOI
2019	Jiao, Y., Davis, J. E., Rautela, J., Carrington, E. M., Ludford-Menting, M. J., Goh, W., . . . Huntington, N. D. (2019). Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes. Cell Death and Differentiation, 26(8), 1516-1530. DOI Scopus13 WoS11 Europe PMC10
2019	van Delft, M. F., Chappaz, S., Khakham, Y., Bui, C. T., Debrincat, M. A., Lowes, K. N., . . . Kile, B. T. (2019). A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis. Nature Chemical Biology, 15(11), 1057-1066. DOI Scopus34 WoS31 Europe PMC31
2018	McArthur, K., Whitehead, L. W., Heddleston, J. M., Li, L., Padman, B. S., Oorschot, V., . . . Kile, B. T. (2018). BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis. Science, 359(6378), 883-+. DOI Scopus742 WoS725 Europe PMC668
2018	Tye, H., Yu, C. H., Simms, L. A., de Zoete, M. R., Kim, M. L., Zakrzewski, M., . . . Masters, S. L. (2018). NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease. Nature Communications, 9(1), 3728-1-3728-11. DOI Scopus104 WoS92 Europe PMC70
2018	Pleines, I., Lebois, M., Gangatirkar, P., Au, A. E., Lane, R. M., Henley, K. J., . . . Josefsson, E. C. (2018). Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion. Blood, 132(2), 197-209. DOI Scopus29 WoS28 Europe PMC18
2018	McArthur, K., Chappaz, S., & Kile, B. T. (2018). Apoptosis in megakaryocytes and platelets: the life and death of a lineage. Blood, 131(6), 605-610. DOI Scopus87 WoS84 Europe PMC67
2018	Lindqvist, L. M., Frank, D., McArthur, K., Dite, T. A., Lazarou, M., Oakhill, J. S., . . . Vaux, D. L. (2018). Autophagy induced during apoptosis degrades mitochondria and inhibits type i interferon secretion. Cell Death and Differentiation, 25(4), 782-794. DOI Scopus59 WoS56 Europe PMC44
2018	Rabbolini, D. J., Chun, Y., Latimer, M., Kunishima, S., Fixter, K., Valecha, B., . . . Morel-Kopp, M. C. (2018). Diagnosis and treatment of MYH9-RD in an Australasian cohort with thrombocytopenia. Platelets, 29(8), 793-800. DOI Scopus18 WoS22 Europe PMC15
2018	Vince, J. E., De Nardo, D., Gao, W., Vince, A. J., Hall, C., McArthur, K., . . . Lawlor, K. E. (2018). The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation. Cell Reports, 25(9), 2339-2353.e4. DOI Scopus191 WoS183 Europe PMC141
2018	Conway, A. J., Brown, F. C., Rank, G., Kile, B. T., Morton, C. J., Jane, S. M., & Curtis, D. J. (2018). Characterization of Tfrc-mutant mice with microcytic phenotypes. Blood Advances, 2(15), 1914-1922. DOI Scopus4 WoS4 Europe PMC4
2018	McArthur, K., & Kile, B. T. (2018). Apoptotic caspases: Multiple or mistaken identities?. Trends in Cell Biology, 28(6), 475-493. DOI Scopus131 WoS124 Europe PMC90
2017	Lorenz, V., Ramsey, H., Liu, Z. J., Italiano, J., Hoffmeister, K., Bihorel, S., . . . Ferrer-Marin, F. (2017). Developmental Stage-Specific Manifestations of Absent TPO/c-MPL Signalling in Newborn Mice. Thrombosis and Haemostasis, 117(12), 2322-2333. DOI Scopus16 WoS14 Europe PMC12
2017	Conway, A. J., Brown, F. C., Fullinfaw, R. O., Kile, B. T., Jane, S. M., & Curtis, D. J. (2017). A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen. DMM Disease Models and Mechanisms, 10(8), 1005-1013. DOI Scopus8 WoS9 Europe PMC10
2017	Brown, F. C., Collett, M., Tremblay, C. S., Rank, G., De Camilli, P., Booth, C. J., . . . Curtis, D. J. (2017). Loss of Dynamin 2 GTPase function results in microcytic anaemia. British Journal of Haematology, 178(4), 616-628. DOI Scopus7 WoS7 Europe PMC7
2017	Yuan, Y., Alwis, I., Wu, M. C. L., Kaplan, Z., Ashworth, K., Bark, D., . . . Jackson, S. P. (2017). Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia. Science Translational Medicine, 9(409), eaam5861-1-eaam5861-14. DOI Scopus62 WoS62 Europe PMC46
2017	Au, A. E., Lebois, M., Sim, S. A., Cannon, P., Corbin, J., Gangatirkar, P., . . . Josefsson, E. C. (2017). Altered B-lymphopoiesis in mice with deregulated thrombopoietin signaling. Scientific Reports, 7(1), 14953-1-14953-10. DOI Scopus4 WoS4 Europe PMC4
2017	Pleines, I., Woods, J., Chappaz, S., Kew, V., Foad, N., Ballester-Beltrán, J., . . . Kile, B. T. (2017). Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia. Journal of Clinical Investigation, 127(3), 814-829. DOI Scopus56 WoS48 Europe PMC45
2017	Thirant, C., Ignacimouttou, C., Lopez, C. K., Diop, M., Le Mouël, L., Thiollier, C., . . . Mercher, T. (2017). ETO2-GLIS2 hijacks transcriptional complexes to drive cellular identity and self-renewal in pediatric acute megakaryoblastic leukemia. Cancer Cell, 31(3), 452-465. DOI Scopus68 WoS69 Europe PMC55
2017	Viant, C., Guia, S., Hennessy, R. J., Rautela, J., Pham, K., Bernat, C., . . . Huntington, N. D. (2017). Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival. Journal of Experimental Medicine, 214(2), 491-510. DOI Scopus56 WoS54 Europe PMC51
2016	Murphy, A. J., Kraakman, M. J., Kammoun, H. L., Dragoljevic, D., Lee, M. K. S., Lawlor, K. E., . . . Masters, S. L. (2016). IL-18 production from the NLRP1 inflammasome prevents obesity and metabolic syndrome. Cell Metabolism, 23(1), 155-164. DOI Scopus149 WoS145 Europe PMC126
2016	Delbridge, A. R. D., Chappaz, S., Ritchie, M. E., Kile, B. T., Strasser, A., & Grabow, S. (2016). Loss of PUMA (BBC3) does not prevent thrombocytopenia caused by the loss of BCL-XL (BCL2L1). British Journal of Haematology, 174(6), 962-969. DOI Scopus7 WoS6 Europe PMC6
2016	Karve, I. P., Zhang, M., Habgood, M., Frugier, T., Brody, K. M., Sashindranath, M., . . . Crack, P. J. (2016). Ablation of type-1 IFN signaling in hematopoietic cells confers protection following traumatic brain injury. eNeuro, 3(1), e0128-15.2016-1-e0128-15.2016-18. DOI Scopus52 WoS53 Europe PMC45
2016	Lebois, M., Dowling, M. R., Gangatirkar, P., Hodgkin, P. D., Kile, B. T., Alexander, W. S., & Josefsson, E. C. (2016). Regulation of platelet lifespan in the presence and absence of thrombopoietin signaling. Journal of Thrombosis and Haemostasis, 14(9), 1882-1887. DOI Scopus21 WoS19 Europe PMC18
2016	Rowley, J. W., Chappaz, S., Corduan, A., Chong, M. M. W., Campbell, R., Khoury, A., . . . Weyrich, A. S. (2016). Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets. Blood, 127(14), 1743-1751. DOI Scopus84 WoS80 Europe PMC67
2016	Lee, E. F., Grabow, S., Chappaz, S., Dewson, G., Hockings, C., Kluck, R. M., . . . Fairlie, W. D. (2016). Physiological restraint of Bak by Bcl-x⌊ is essential for cell survival. Genes and Development, 30(10), 1240-1250. DOI Scopus42 WoS37 Europe PMC33
2016	Keniry, A., Gearing, L. J., Jansz, N., Liu, J., Holik, A. Z., Hickey, P. F., . . . Blewitt, M. E. (2016). Setdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing. Epigenetics & Chromatin, 9(1), 16=1-16-20. DOI Scopus57 WoS54 Europe PMC48
2015	Zhang, J. G., Farley, A., Nicholson, S. E., Willson, T. A., Zugaro, L. M., Simpson, R. J., . . . Baca, M. (2015). Correction: The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation (Proceedings of the National Academy of Sciences of the United States of America (1999) 96, 5 (2071-2076) DOI: 10.1073/pnas.96.5.2071). Proceedings of the National Academy of Sciences of the United States of America, 112(22), E2979. DOI Scopus8 WoS8 Europe PMC5
2015	White, M., & Kile, B. (2015). Stressed mitochondria sound the alarm. Immunology and Cell Biology, 93(5), 427-428. DOI Scopus5 WoS5 Europe PMC3
2015	Kile, B. (2015). Aging platelets stimulate TPO production. Nature Medicine, 21(1), 11-12. DOI Scopus7 WoS5 Europe PMC5
2015	Carpinelli, M. R., Kruse, E. A., Arhatari, B. D., Debrincat, M. A., Ogier, J. M., Bories, J. C., . . . Burt, R. A. (2015). Mice haploinsufficient for Ets1 and Fli1 display middle ear abnormalities and model aspects of Jacobsen syndrome. American Journal of Pathology, 185(7), 1867-1876. DOI Scopus15 WoS12 Europe PMC11
2015	Debrincat, M. A., Pleines, I., Lebois, M., Lane, R. M., Holmes, M. L., Corbin, J., . . . Josefsson, E. C. (2015). BCL-2 is dispensable for thrombopoiesis and platelet survival. Cell Death and Disease, 6(4), e1721-1-e1721-8. DOI Scopus71 WoS66 Europe PMC54
2015	Schevzov, G., Kee, A. J., Wang, B., Sequeira, V. B., Hook, J., Coombes, J. D., . . . Gunning, P. W. (2015). Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments. Molecular Biology of the Cell, 26(13), 2475-2490. DOI Scopus55 WoS54 Europe PMC47
2015	Brown, F. C., Conway, A. J., Cerruti, L., Collinge, J. E., McLean, C., Wiley, J. S., . . . Curtis, D. J. (2015). Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model. Blood, 126(26), 2863-2870. DOI Scopus17 WoS18 Europe PMC16
2015	Chirn, G. W., Rahman, R., Sytnikova, Y. A., Matts, J. A., Zeng, M., Gerlach, D., . . . Lau, N. C. (2015). Conserved piRNA expression from a distinct set of piRNA cluster loci in eutherian mammals. PLoS Genetics, 11(11), e1005652-1-e1005652-26. DOI Scopus70 WoS67 Europe PMC67
2015	Kedzierski, L., Clemens, E. B., Bird, N. L., Kile, B. T., Belz, G. T., Nicola, N. A., . . . Nicholson, S. E. (2015). SOCS4 is dispensable for an efficient recall response to influenza despite being required for primary immunity. Immunology and Cell Biology, 93(10), 909-913. DOI Scopus11 WoS11 Europe PMC5
2015	Cottle, D. L., Ursino, G. M. A., Ip, S. C. I., Jones, L. K., Ditommaso, T., Hacking, D. F., . . . Smyth, I. M. (2015). Fetal inhibition of inflammation improves disease phenotypes in harlequin ichthyosis. Human Molecular Genetics, 24(2), 436-449. DOI Scopus20 WoS17 Europe PMC18
2015	Kim, M. L., Chae, J. J., Park, Y. H., De Nardo, D., Stirzaker, R. A., Ko, H. J., . . . Masters, S. L. (2015). Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β. Journal of Experimental Medicine, 212(6), 927-938. DOI Scopus122 WoS110 Europe PMC101
2015	Carmichael, C., Goossens, S., Kile, B., & Haigh, J. J. (2015). A NOVEL ROLE FOR THE EMT REGULATOR, SNAIL IN HEMATOPOIESIS AND LEUKEMIA. EXPERIMENTAL HEMATOLOGY, 43(9), S56. DOI WoS1
2014	Allam, R., Lawlor, K. E., Yu, E. C. W., Mildenhall, A. L., Moujalled, D. M., Lewis, R. S., . . . Vince, J. E. (2014). Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming. EMBO Reports, 15(9), 982-990. DOI Scopus201 WoS189 Europe PMC175
2014	Josefsson, E. C., Burnett, D. L., Lebois, M., Debrincat, M. A., White, M. J., Henley, K. J., . . . Kile, B. T. (2014). Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways. Nature Communications, 5(1), 3455-1-3455-14. DOI Scopus73 WoS67 Europe PMC52
2014	White, M. J., McArthur, K., Metcalf, D., Lane, R. M., Cambier, J. C., Herold, M. J., . . . Kile, B. T. (2014). Apoptotic caspases suppress mtDNA-induced STING-mediated type i IFN production. Cell, 159(7), 1549-1562. DOI Scopus788 WoS769 Europe PMC664
2014	Kedzierski, L., Linossi, E. M., Kolesnik, T. B., Day, E. B., Bird, N. L., Kile, B. T., . . . Nicholson, S. E. (2014). Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection. PLoS Pathogens, 10(5), e1004134-1-e1004134-13. DOI Scopus59 WoS55 Europe PMC48
2014	Vandenberg, C. J., Josefsson, E. C., Campbell, K. J., James, C., Lawlor, K. E., Kile, B. T., & Cory, S. (2014). Loss of Bak enhances lymphocytosis but does not ameliorate thrombocytopaenia in BCL-2 transgenic mice. Cell Death and Differentiation, 21(5), 676-684. DOI Scopus15 WoS15 Europe PMC14
2014	Mitchell, W. B., Pinheiro, M. P., Boulad, N., Kaplan, D., Edison, M. N., Psaila, B., . . . Bussel, J. B. (2014). Effect of thrombopoietin receptor agonists on the apoptotic profile of platelets in patients with chronic immune thrombocytopenia. American Journal of Hematology, 89(12), E228-E234. DOI Scopus36 WoS31 Europe PMC27
2014	Potts, K. S., Sargeant, T. J., Markham, J. F., Shi, W., Biben, C., Josefsson, E. C., . . . Taoudi, S. (2014). A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo. Blood, 124(17), 2725-2729. DOI Scopus55 WoS47 Europe PMC41
2014	Ogier, J. M., Carpinelli, M. R., Arhatari, B. D., Symons, R. C. A., Kile, B. T., & Burt, R. A. (2014). CHD7 deficiency in " Looper", a new mouse model of CHARGE syndrome, results in ossicle malformation, otosclerosis and hearing impairment. PLoS ONE, 9(5), e97559-1-e97559-11. DOI Scopus22 WoS22 Europe PMC22
2014	Gerlic, M., Croker, B., Cengia, L., Moayeri, M., Kile, B., & Masters, S. (2014). NLRP1a expression in srebp-1a-deficient mice. Cell Metabolism, 19(3), 345-346. DOI Scopus7 WoS7 Europe PMC6
2014	Carpinelli, M. R., Voss, A. K., Manning, M. G., Perera, A. A., Cooray, A. A., Kile, B. T., & Burt, R. A. (2014). A new mouse model of Canavan leukodystrophy displays hearing impairment due to central nervous system dysmyelination. Disease Models and Mechanisms, 7(6), 649-657. DOI Scopus11 WoS11 Europe PMC10
2014	Liu, Z. J., Hoffmeister, K. M., Hu, Z., Mager, D. E., Ait-Oudhia, S., Debrincat, M. A., . . . Sola-Visner, M. (2014). Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan. Blood, 123(22), 3381-3389. DOI Scopus63 WoS53 Europe PMC46
2014	Kile, B. T. (2014). The role of apoptosis in megakaryocytes and platelets. British Journal of Haematology, 165(2), 217-226. DOI Scopus108 WoS92 Europe PMC76
2013	Dowling, M. R., Josefsson, E. C., Henley, K. J., Kile, B. T., & Hodgkin, P. D. (2013). A model for studying the hemostatic consumption or destruction of platelets. PLoS ONE, 8(3), e57783-1-e57783-14. DOI Scopus6 WoS4 Europe PMC5
2013	Tang, J. Z., Carmichael, C. L., Shi, W., Metcalf, D., Ng, A. P., Hyland, C. D., . . . Alexander, W. S. (2013). Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia. Proceedings of the National Academy of Sciences, 110(15), 6091-6096. DOI Scopus19 WoS19 Europe PMC19
2013	Carpinelli, M. R., Manning, M. G., Kile, B. T., & Rachel, A. B. (2013). Two ENU-induced alleles of Atp2b2 cause deafness in mice. PLoS ONE, 8(6), e67479-1-e67479-8. DOI Scopus9 WoS10 Europe PMC10
2013	Downes, C. E., Wong, C. H. Y., Henley, K. J., Guio-Aguilar, P. L., Zhang, M., Ates, R., . . . Crack, P. J. (2013). MyD88 is a critical regulator of hematopoietic cell-mediated neuroprotection seen after stroke. PLoS ONE, 8(3), e57948. DOI Scopus20 WoS20 Europe PMC18
2013	Fu, Y., Mukhamedova, N., Ip, S., D'Souza, W., Henley, K. J., Ditommaso, T., . . . Sviridov, D. (2013). ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis. Cell Metabolism, 18(2), 225-238. DOI Scopus48 WoS49 Europe PMC37
2013	Takiguchi, M., Dow, L. E., Prier, J. E., Carmichael, C. L., Kile, B. T., Turner, S. J., . . . Dickins, R. A. (2013). Variability of inducible expression across the hematopoietic system of tetracycline transactivator transgenic mice. PLoS ONE, 8(1), e54009-1-e54009-10. DOI Scopus24 WoS25 Europe PMC26
2013	Brown, F. C., Scott, N., Rank, G., Collinge, J. E., Vadolas, J., Vickaryous, N., . . . Curtis, D. J. (2013). ENU mutagenesis identifies the first mouse mutants reproducing human β-thalassemia at the genomic level. Blood Cells Molecules and Diseases, 50(2), 86-92. DOI Scopus16 WoS15 Europe PMC14
2013	Fleming, P., Kvansakul, M., Voigt, V., Kile, B. T., Kluck, R. M., Huang, D. C. S., . . . Andoniou, C. E. (2013). MCMV-mediated inhibition of the pro-apoptotic bak protein is required for optimal in vivo replication. PLoS Pathogens, 9(2), e1003192-1-e1003192-12. DOI Scopus26 WoS24 Europe PMC20
2013	Mason, K. D., Lin, A., Robb, L., Josefsson, E. C., Henley, K. J., Gray, D. H. D., . . . O'Reilly, L. A. (2013). Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease. Proceedings of the National Academy of Sciences of the United States of America, 110(7), 2599-2604. DOI Scopus46 WoS43 Europe PMC38
2013	Qiao, J., Schoenwaelder, S. M., Mason, K. D., Tran, H., Davis, A. K., Kaplan, Z. S., . . . Gardiner, E. E. (2013). Low adhesion receptor levels on circulating platelets in patients with lymphoproliferative diseases before receiving Navitoclax (ABT-263). Blood, 121(8), 1479-1481. DOI Scopus23 WoS22 Europe PMC16
2013	Putoczki, T. L., Thiem, S., Loving, A., Busuttil, R. A., Wilson, N. J., Ziegler, P. K., . . . Ernst, M. (2013). Interleukin-11 is the dominant Il-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically. Cancer Cell, 24(2), 257-271. DOI Scopus352 WoS335 Europe PMC288
2013	Carpinelli, M. R., Manning, M. G., Kile, B. T., & Burt, R. A. (2013). Erratum: Two ENU-induced alleles of atp2b2 cause deafness in mice. Plos One, 8(7). DOI Scopus2
2012	Masters, S. L., Gerlic, M., Metcalf, D., Preston, S., Pellegrini, M., O'Donnell, J. A., . . . Croker, B. A. (2012). NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells. Immunity, 37(6), 1009-1023. DOI Scopus260 WoS247 Europe PMC220
2012	Lindqvist, L. M., Vikström, I., Chambers, J. M., McArthur, K., Ann Anderson, M., Henley, K. J., . . . Huang, D. C. S. (2012). Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor. Cell Death and Disease, 3(10), e409-1-e409-9. DOI Scopus47 WoS44 Europe PMC40
2012	Zhang, J. G., Czabotar, P. E., Policheni, A. N., Caminschi, I., San Wan, S., Kitsoulis, S., . . . Lahoud, M. H. (2012). The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments. Immunity, 36(4), 646-657. DOI Scopus273 WoS253 Europe PMC238
2012	White, M. J., Schoenwaelder, S. M., Josefsson, E. C., Jarman, K. E., Henley, K. J., James, C., . . . Kile, B. T. (2012). Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function. Blood, 119(18), 4283-4290. DOI Scopus71 WoS60 Europe PMC54
2012	Debrincat, M., Josefsson, E., James, C., Henley, K., Ellis, S., Lebois, M., . . . Kile, B. (2012). Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival. Blood, 119(24), 5850-5858. DOI Scopus72 WoS66 Europe PMC55
2012	Josefsson, E. C., White, M. J., Dowling, M. R., & Kile, B. T. (2012). Platelet life span and apoptosis. Methods in Molecular Biology, 788, 59-71. DOI Scopus32 Europe PMC25
2012	Carpinelli, M. R., Burt, R. A., & Kile, B. T. (2012). Genetic Modifier Screens in Mice.. Current protocols in mouse biology, 2(1), 75-87. DOI Europe PMC1
2012	Kauppi, M., Hilton, A. A., Metcalf, D., Ng, A. P., Hyland, C. D., Collinge, J. E., . . . Alexander, W. S. (2012). Thrombocytopenia and erythrocytosis in mice with a mutation in the gene encoding the hemoglobin β minor chain. Proceedings of the National Academy of Sciences of the United States of America, 109(2), 576-581. DOI Scopus4 WoS3 Europe PMC3
2012	Kile, B. T. (2012). The spreading influence of platelet HDACs. Blood, 120(20), 4118-4119. DOI Scopus1
2012	Carmichael, C. L., Metcalf, D., Henley, K. J., Kruse, E. A., Di Rago, L., Mifsud, S., . . . Kile, B. T. (2012). Hematopoietic overexpression of the transcription factor Erg induces lymphoid and erythro-megakaryocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America, 109(38), 15437-15442. DOI Scopus47 WoS47 Europe PMC41
2012	Verhagen, A. M., De Graaf, C. A., Baldwin, T. M., Goradia, A., Collinge, J. E., Kile, B. T., . . . Hilton, D. J. (2012). Reduced lymphocyte longevity and homeostatic proliferation in lamin B receptor-deficient mice results in profound and progressive lymphopenia. Journal of Immunology, 188(1), 122-134. DOI Scopus9 WoS9 Europe PMC10
2012	Kraemer, B. F., Campbell, R. A., Schwertz, H., Franks, Z. G., De Abreu, A. V., Grundler, K., . . . Weyrich, A. S. (2012). Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets. Blood, 120(25), 5014-5020. DOI Scopus55 WoS52 Europe PMC43
2011	Fairfield, H., Gilbert, G. J., Barter, M., Corrigan, R. R., Curtain, M., Ding, Y., . . . Reinholdt, L. G. (2011). Mutation discovery in mice by whole exome sequencing. Genome Biology, 12(9), 12 pages. DOI Scopus94 WoS89 Europe PMC86
2011	Josefsson, E. C., James, C., Henley, K. J., Debrincat, M. A., Rogers, K. L., Dowling, M. R., . . . Kile, B. T. (2011). Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets. Journal of Experimental Medicine, 208(10), 2017-2031. DOI Scopus161 WoS145 Europe PMC129
2011	Nguyen, N. Y. N., Maxwell, M. J., Ooms, L. M., Davies, E. M., Hilton, A. A., Collinge, J. E., . . . Curtis, D. J. (2011). An ENU-induced mouse mutant of SHIP1 reveals a critical role of the stem cell isoform for suppression of macrophage activation. Blood, 117(20), 5362-5371. DOI Scopus15 WoS14 Europe PMC12
2011	Ng, A. P., Loughran, S. J., Metcalf, D., Hyland, C. D., De Graaf, C. A., Hu, Y., . . . Alexander, W. S. (2011). Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice. Blood, 118(9), 2454-2461. DOI Scopus49 WoS45 Europe PMC44
2011	Bishton, M. J., Harrison, S. J., Martin, B. P., McLaughlin, N., James, C., Josefsson, E. C., . . . Johnstone, R. W. (2011). Deciphering the molecular and biologic processes that mediate histone deacetylase inhibitor - Induced thrombocytopenia. Blood, 117(13), 3658-3668. DOI Scopus134 WoS122 Europe PMC101
2011	Taoudi, S., Bee, T., Hilton, A., Knezevic, K., Scott, J., Willson, T. A., . . . Hilton, D. J. (2011). ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification. Genes and Development, 25(3), 251-262. DOI Scopus96 WoS84 Europe PMC80
2011	Schoenwaelder, S. M., Jarman, K. E., Gardiner, E. E., Hua, M., Qiao, J., White, M. J., . . . Jackson, S. P. (2011). Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets. Blood, 118(6), 1663-1674. DOI Scopus289 WoS269 Europe PMC240
2010	Kelly, P. N., White, M. J., Goschnick, M. W., Fairfax, K. A., Tarlinton, D. M., Kinkel, S. A., . . . Strasser, A. (2010). Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development. Cell Death and Differentiation, 17(10), 1655-1664. DOI Scopus60 WoS51 Europe PMC50
2010	Greig, K. T., De Graaf, C. A., Murphy, J. M., Carpinelli, M. R., Pang, S. H. M., Frampton, J., . . . Nutt, S. L. (2010). Critical roles for c-Myb in lymphoid priming and early B-cell development. Blood, 115(14), 2796-2805. DOI Scopus60 WoS58 Europe PMC57
2010	Takiguchi, M., James, C., Josefsson, E. C., Carmichael, C. L., Premsrirut, P. K., Lowe, S. W., . . . Dickins, R. A. (2010). Transgenic, inducible RNAi in megakaryocytes and platelets in mice. Journal of Thrombosis and Haemostasis, 8(12), 2751-2756. DOI Scopus8 WoS8 Europe PMC8
2010	Ng, A. P., Hyland, C. D., Metcalf, D., Carmichael, C. L., Loughran, S. J., Di Rago, L., . . . Alexander, W. S. (2010). Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome. Blood, 115(19), 3966-3969. DOI Scopus63 WoS52 Europe PMC46
2010	Dowling, M. R., Josefsson, E. C., Henley, K. J., Hodgkin, P. D., & Kile, B. T. (2010). Platelet senescence is regulated by an internal timer, not damage inflicted by hits. Blood, 116(10), 1776-1778. DOI Scopus56 WoS48 Europe PMC45
2010	White, M. J., & Kile, B. T. (2010). Apoptotic Processes in Megakaryocytes and Platelets. Seminars in Hematology, 47(3), 227-234. DOI Scopus37 WoS32 Europe PMC31
2010	Cordell, P. A., Kile, B. T., Standeven, K. F., Josefsson, E. C., Pease, R. J., & Grant, P. J. (2010). Association of coagulation factor XIII-A with Golgi proteins within monocyte-macrophages: Implications for subcellular trafficking and secretion. Blood, 115(13), 2674-2681. DOI Scopus52 WoS48 Europe PMC44
2009	Hilton, D. J., Kile, B. T., & Alexander, W. S. (2009). Mutational inhibition of c-Myb or p300 ameliorates treatment-induced thrombocytopenia. Blood, 113(22), 5599-5604. DOI Scopus7 WoS6 Europe PMC9
2009	Kruse, E. A., Loughran, S. J., Baldwin, T. M., Josefsson, E. C., Ellis, S., Watson, D. K., . . . Kile, B. T. (2009). Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage. Proceedings of the National Academy of Sciences of the United States of America, 106(33), 13814-13819. DOI Scopus82 WoS76 Europe PMC74
2009	Ellett, F., Kile, B. T., & Lieschke, G. J. (2009). The role of the ETS factor erg in zebrafish vasculogenesis. Mechanisms of Development, 126(3-4), 220-229. DOI Scopus27 WoS25 Europe PMC21
2009	Rank, G., Sutton, R., Marshall, V., Lundie, R. J., Caddy, J., Romeo, T., . . . Jane, S. M. (2009). Novel roles for erythroid Ankyrin-1 revealed through an ENU-induced null mouse mutant. Blood, 113(14), 3352-3362. DOI Scopus41 WoS39 Europe PMC38
2009	Verhagen, A. M., Wallace, M. E., Goradia, A., Jones, S. A., Croom, H. A., Metcalf, D., . . . Starr, R. (2009). A kinase-dead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency. Journal of Immunology, 182(4), 2020-2029. DOI Scopus16 WoS15 Europe PMC14
2009	Schoenwaelder, S. M., Yuan, Y., Josefsson, E. C., White, M. J., Yao, Y., Mason, K. D., . . . Jackson, S. P. (2009). Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function. Blood, 114(3), 663-666. DOI Scopus275 WoS262 Europe PMC226
2008	Smyth, I., Hacking, D. F., Hilton, A. A., Mukhamedova, N., Meikle, P. J., Ellis, S., . . . Hilton, D. J. (2008). A mouse model of harlequin ichthyosis delineates a key role for Abca12 in lipid homeostasis. Plos Genetics, 4(9), 11 pages. DOI Scopus72 WoS62 Europe PMC56
2008	Kauppi, M., Murphy, J. M., De Graaf, C. A., Hyland, C. D., Greig, K. T., Metcalf, D., . . . Alexander, W. S. (2008). Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl/mice. Blood, 112(8), 3148-3153. DOI Scopus27 WoS28 Europe PMC27
2008	Loughran, S. J., Kruse, E. A., Hacking, D. F., de Graaf, C. A., Hyland, C. D., Willson, T. A., . . . Kile, B. T. (2008). The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells. Nature Immunology, 9(7), 810-819. DOI Scopus225 WoS206 Europe PMC201
2008	Burt, R. A., Joseph, J. E., Milliken, S., Collinge, J. E., & Kile, B. T. (2008). Description of a novel mutation leading to MYH9-related disease. Thrombosis Research, 122(6), 861-863. DOI Scopus15 WoS15 Europe PMC13
2007	Kile, B. T., Panopoulos, A. D., Stirzaker, R. A., Hacking, D. F., Tahtamouni, L. H., Willson, T. A., . . . Justice, M. J. (2007). Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia. Blood, 110(7), 2371-2380. DOI Scopus99 WoS95 Europe PMC83
2007	Greig, K. T., Antonchuk, J., Metcalf, D., Morgan, P. O., Krebs, D. L., Zhang, J. G., . . . Kile, B. T. (2007). Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development. Molecular and Cellular Biology, 27(16), 5849-5859. DOI Scopus57 WoS54 Europe PMC49
2007	Silver, J. D., Hilton, D. J., Bahlo, M., & Kile, B. T. (2007). Probabilistic analysis of recessive mutagenesis screen strategies. Mammalian Genome, 18(1), 5-22. DOI Scopus4 WoS2 Europe PMC2
2007	Tucker, E., O'Donnell, K., Fuchsberger, M., Hilton, A. A., Metcalf, D., Greig, K., . . . Starr, R. (2007). A novel mutation in the Nfkb2 gene generates an NF-κB2 "super repressor". Journal of Immunology, 179(11), 7514-7522. DOI Scopus68 WoS71 Europe PMC66
2007	Mason, K. D., Carpinelli, M. R., Fletcher, J. I., Collinge, J. E., Hilton, A. A., Ellis, S., . . . Kile, B. T. (2007). Programmed Anuclear Cell Death Delimits Platelet Life Span. Cell, 128(6), 1173-1186. DOI Scopus908 WoS839 Europe PMC735
2007	Debrincat, M. A., Zhang, J. G., Willson, T. A., Silke, J., Connolly, L. M., Simpson, R. J., . . . Hilton, D. J. (2007). Ankyrin repeat and suppressors of cytokine signaling box protein Asb-9 targets creatine kinase B for degradation. Journal of Biological Chemistry, 282(7), 4728-4737. DOI Scopus45 WoS44 Europe PMC37
2006	Alexander, W. S., Viney, E. M., Zhang, J. G., Metcalf, D., Kauppi, M., Hyland, C. D., . . . Hilton, D. J. (2006). Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene. Proceedings of the National Academy of Sciences of the United States of America, 103(44), 16442-16447. DOI Scopus72 WoS66 Europe PMC59
2005	Kile, B. T., & Hilton, D. J. (2005). The art and design of genetic screens: Mouse. Nature Reviews Genetics, 6(7), 557-567. DOI Scopus88 WoS78 Europe PMC67
2003	Kile, B. T., Hentges, K. E., Clark, A. T., Nakamura, H., Salinger, A. P., Liu, B., . . . Justice, M. J. (2003). Functional genetic analysis of mouse chromosome 11. Nature, 425(6953), 81-86. DOI Scopus185 WoS162 Europe PMC158
2003	Kile, B. T., Mason-Garrison, C. L., & Justice, M. J. (2003). Sex and strain-related differences in the peripheral blood cell values of inbred mouse strains. Mammalian Genome, 14(1), 81-85. DOI Scopus41 WoS36 Europe PMC34
2002	Kile, B. T., Schulman, B. A., Alexander, W. S., Nicola, N. A., Martin, H. M. E., & Hilton, D. J. (2002). The SOCS box: A tale of destruction and degradation. Trends in Biochemical Sciences, 27(5), 235-241. DOI Scopus391 WoS360 Europe PMC309
2001	Kile, B. T., Metcalf, D., Mifsud, S., DiRago, L., Nicola, N. A., Hilton, D. J., & Alexander, W. S. (2001). Functional analysis of Asb-1 using genetic modification in mice. Molecular and Cellular Biology, 21(18), 6189-6197. DOI Scopus53 WoS53 Europe PMC46
2001	Kile, B. T., & Alexander, W. S. (2001). The suppressors of cytokine signalling (SOCS). Cellular and Molecular Life Sciences, 58(11), 1627-1635. DOI Scopus149 WoS144 Europe PMC116
2001	Kile, B. T., Nicola, N. A., & Alexander, W. S. (2001). Negative regulators of cytokine signaling. International Journal of Hematology, 73(3), 292-298. DOI Scopus64 WoS60 Europe PMC47
2000	Kile, B. T., Viney, E. M., Willson, T. A., Brodnicki, T. C., Cancilla, M. R., Herlihy, A. S., . . . Alexander, W. S. (2000). Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4. Gene, 258(1-2), 31-41. DOI Scopus46 WoS46 Europe PMC41
1999	Cutts, S. M., Fowler, K. J., Kile, B. T., Hii, L. L. P., O'Dowd, R. A., Hudson, D. F., . . . Choo, K. H. A. (1999). Defective chromosome segregation, microtubule bundling and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice. Human Molecular Genetics, 8(7), 1145-1155. DOI Scopus88 WoS85 Europe PMC76
1999	Zhang, J. G., Farley, A., Nicholson, S. E., Willson, T. A., Zugaro, L. M., Simpson, R. J., . . . Baca, M. (1999). The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proceedings of the National Academy of Sciences of the United States of America, 96(5), 2071-2076. DOI Scopus553 WoS532 Europe PMC439
1999	Alexander, W. S., Starr, R., Metcalf, D., Nicholson, S. E., Farley, A., Elefanty, A. G., . . . Hilton, D. J. (1999). Suppressors of cytokine signaling (SOCS): Negative regulators of signal transduction. Journal of Leukocyte Biology, 66(4), 588-592. DOI Scopus108 WoS103 Europe PMC75
1999	Saffery, R., Irvine, D. V., Kile, B. T., Hudson, D. F., Cutts, S. M., & Choo, K. H. A. (1999). Cloning, expression, and promoter structure of a mammalian inner centromere protein (INCENP). Mammalian Genome, 10(4), 415-418. DOI Scopus8 WoS8 Europe PMC7
1998	Fowler, K. J., Saffery, R., Kile, B. T., Irvine, D. V., Hudson, D. F., Trowell, H. E., & Choo, K. H. A. (1998). Genetic mapping of mouse centromere protein (Incenp and Cenpe) genes. Cytogenetics and Cell Genetics, 82(1-2), 67-70. DOI Scopus5 WoS5 Europe PMC3

Book Chapters

Year	Citation
2013	Josefsson, E. C., Dowling, M. R., Lebois, M., & Kile, B. T. (2013). The Regulation of Platelet Life Span. In Platelets (pp. 51-65). Elsevier. DOI Scopus22
2012	Josefsson, E. C., Dowling, M. R., Lebois, M., & Kile, B. T. (2012). The Regulation of Platelet Life Span. In Platelets, Third Edition (pp. 51-65). DOI
2009	Josefsson, E. C., & Kile, B. T. (2009). Cell death in the hematopoietic system. In Essentials of Apoptosis A Guide for Basic and Clinical Research (pp. 443-459). Humana Press. DOI Scopus4

Conference Papers

Year	Citation
2021	Pang, E. S., Daraj, G., Macri, C., Balka, K., de Nardo, D., Hochrein, H., . . . O'Keeffe, M. (2021). Activation of stimulator of interferon genes in dendritic cells induces interferon-lambda and subset- and species-specific dendritic cell death. In JOURNAL OF IMMUNOLOGY Vol. 206 (pp. 2 pages). AMER ASSOC IMMUNOLOGISTS.
2020	Denorme, F., Manne, B., Kosaka, Y., Majersik, J., Kile, B., Rondina, M., & Campbell, R. (2020). Platelet Cyclophilin D Mediates Neutrophil Recruitment and Ischemic Stroke Outcomes in Mice. In STROKE Vol. 51 (pp. 2 pages). Los Angeles, CA: LIPPINCOTT WILLIAMS & WILKINS.
2019	Denorme, F., Manne, B. K., Kosaka, Y., Kile, B., Rondina, M. T., & Campbell, R. A. (2019). Cyclophilin D Mediated Platelet Necrosis Regulates Ischemic Stroke Outcomes in Mice. In BLOOD Vol. 134 (pp. 4 pages). Orlando, FL: AMER SOC HEMATOLOGY. DOI WoS1
2019	Pang, S., Wallis, G., Mendonca, S., Hisana, A., Chappaz, S., Rautela, J., . . . Heng, T. (2019). DISSECTING THE MOLECULAR PATHWAYS OF APOPTOSIS IN MESENCHYMAL STROMAL CELL THERAPY. In CYTOTHERAPY Vol. 21 (pp. S85). ELSEVIER SCI LTD. DOI
2016	Carmichael, C. L., Goossens, S., Wang, J., Thao, N., Haigh, K., Berx, G., . . . Haigh, J. J. (2016). The EMT Modulator SNAI1 Drives AML Development Via Its Interaction with the Chromatin Modulator LSD1. In BLOOD Vol. 128 (pp. 4 pages). San Diego, CA: AMER SOC HEMATOLOGY. DOI WoS1
2016	Strassel, C., Hovasse, A., Moog, S., Mageira, M., Batzenschlager, M., Schaeffer-Reiss, C., . . . Lanza, F. (2016). Selected Expression and Functional Importance of alpha 4a-Tubulin in Platelet Biogenesis. In BLOOD Vol. 128 (pp. 3 pages). San Diego, CA: AMER SOC HEMATOLOGY. DOI
2016	Thirant, C., Lopez, C. K., Ignacimouttou, C., Diop, M., Le Mouel, L., Thiollier, C., . . . Mercher, T. (2016). ETO2-GLIS2 Controls Differentiation Arrest and Self-Renewal through Aberrant Enhancers Regulation in Pediatric Leukemia. In BLOOD Vol. 128 (pp. 5 pages). San Diego, CA: AMER SOC HEMATOLOGY. DOI
2015	Pleines, I., Lebois, M., Au, A. E. -L., Lane, R. M., Henley, K. J., Corbin, J., . . . Josefsson, E. C. (2015). Extended Platelet In Vivo Survival Results in Exhausted Platelets. In BLOOD Vol. 126 (pp. 3 pages). Orlando, FL: AMER SOC HEMATOLOGY. DOI WoS3
2015	Lebois, M., Dowling, M. R., Hodgkin, P. D., Kile, B. T., Alexander, W. S., & Josefsson, E. C. (2015). Regulation of Platelet Lifespan in the Presence and Absence of TPO Signaling. In BLOOD Vol. 126 (pp. 2 pages). Orlando, FL: AMER SOC HEMATOLOGY.
2015	Keniry, A., Gearing, L., Jansz, N., Liu, J., Kinkel, S., Breslin, K., . . . Blewitt, M. E. (2015). IHSTONE H3 LYSINE 9 METHYLATION IS INVOLVED NOT ONLY IN MAINTAINING EPIGENETIC SILENCING, BUT IS ESSENTIAL FOR SETTING UP GENE SILENCING. In EXPERIMENTAL HEMATOLOGY Vol. 43 (pp. S38). Kyoto, JAPAN: ELSEVIER SCIENCE INC. DOI
2014	Pleines, I., Woods, J., Turro, E., Foad, N., Chappaz, S., Lane, R. M., . . . Kile, B. T. (2014). Mutations in Tropomyosin 4 Cause Macrothrombocytopenia in Mice and Humans. In BLOOD Vol. 124 (pp. 3 pages). AMER SOC HEMATOLOGY. DOI WoS1
2014	White, M. J., McArthur, K., Metcalf, D., Cambier, J., Bedoui, S., Ritchie, M., . . . Kile, B. (2014). The apoptotic caspase cascade suppresses mitochondrial DNA-induced STING-mediated type I IFN production by dying cells. In CYTOKINE Vol. 70 (pp. 75-76). Melbourne, AUSTRALIA: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD. DOI
2014	Potts, K., Sargeant, T., Markham, J., Shi, W., Dawson, C., Josefsson, E., . . . Taoudi, S. (2014). IDENTIFICATION OF DIPLOID PLATELET-FORMING CELLS PRIOR TO THE EMERGENCE OF POLYPLOIDY MEGAKARYOCYTE IN THE MOUSE EMBRYO. In EXPERIMENTAL HEMATOLOGY Vol. 42 (pp. S56). Montreal, CANADA: ELSEVIER SCIENCE INC. DOI
2013	Josefsson, E. C., Lebois, M., Cannon, P., Moujalled, D., Rutgersson, A., Faraj, F., . . . Alexander, S. (2013). Role of thrombopoietin signalling in murine B-cell lymphoma. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 509). WILEY-BLACKWELL.
2013	Pleines, I., Chappaz, S., Lane, R., Kostadima, M. A., Schevzov, G., Ghevaert, C., . . . Kile, B. T. (2013). Tropomyosin 4 is a novel regulator of platelet production in mice and humans. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 159-160). WILEY-BLACKWELL.
2013	Carmichael, C., Tang, J. Z., Metcalf, D., Shi, W., Henley, K., Ng, A., . . . Kile, B. (2013). OVEREXPRESSION OF THE ETS-FAMILY TRANSCRIPTION FACTOR ERG AND DYSREGULATED CYTOKINE SIGNALING DRIVE ERYTHROID LEUKEMIA DEVELOPMENT IN MICE. In EXPERIMENTAL HEMATOLOGY Vol. 41 (pp. S21). Vienna, AUSTRIA: ELSEVIER SCIENCE INC. DOI
2013	Kile, B. (2013). THE INTRINSIC APOPTOSIS CASPASE CASCADE REGULATES HEMATOPOIETIC STEM CELL HOMEOSTASIS AND FUNCTION. In EXPERIMENTAL HEMATOLOGY Vol. 41 (pp. S4). Vienna, AUSTRIA: ELSEVIER SCIENCE INC. DOI WoS1
2012	Josefsson, E. C., Burnett, D. L., Debrincat, M. A., Henley, K. J., Lane, R. M., Lebois, M., . . . Kile, B. T. (2012). Platelet Production Occurs Independently of Both the Intrinsic and Extrinsic Apoptosis Pathways. In BLOOD Vol. 120 (pp. 2 pages). GA, Atlanta: AMER SOC HEMATOLOGY. DOI
2012	Jessie, E. E., Ruisi, M. M., Green, D., Burt, R., Davis, J., Macatangay, R. A., . . . Bussel, J. B. (2012). Radioulnar Synostosis-Hematology (RUS-H) Syndrome: Description of the New Syndrome and Comparison to Similar Syndromes. In BLOOD Vol. 120 (pp. 2 pages). Atlanta, GA: AMER SOC HEMATOLOGY. DOI
2012	Masters, S. L., Gerlic, M., Metcalf, D., Preston, S. P., Pellegrini, M., O'Donnell, J. A., . . . Kile, B. T. (2012). Activation of the NLRP1 Inflammasome Induces the Pyroptotic Death of Hematopoietic Progenitor Cells. In BLOOD Vol. 120 (pp. 2 pages). GA, Atlanta: AMER SOC HEMATOLOGY. DOI
2012	Carmichael, C. L., Metcalf, D., Henley, K. J., Kruse, E. A., Di Rago, L., Mifsud, S., . . . Kile, B. T. (2012). Hematopoietic Overexpression of the ETS Family Transcription Factor Erg, or the Oncogenic Fusion Protein TLS-ERG, Induces Erythro-Megakaryocytic Leukemia. In BLOOD Vol. 120 (pp. 2 pages). GA, Atlanta: AMER SOC HEMATOLOGY. DOI
2011	Mitchell, W. B., Edison, M. N., Pinheiro, M. P., Boulad, N., Psaila, B., Karpoff, M., . . . Bussel, J. B. (2011). The Effect of Eltrombopag on Platelet Resistance to Apoptosis: The Role of the Bcl-Xl Pathway. In BLOOD Vol. 118 (pp. 524). San Diego, CA: AMER SOC HEMATOLOGY.
2011	Bishton, M. J., Prince, M., Johnstone, R. W., Harrison, S. J., & Kile, B. T. (2011). The Pan Histone Deacetylase Inhibitor Panobinostat and the Iso-Selective Inhibitor Romidepsin Reduce Glycoprotein VI Expression and Inhibit Platelet Activation in Response to Collagen Related Peptide. In BLOOD Vol. 118 (pp. 522-523). San Diego, CA: AMER SOC HEMATOLOGY.
2011	Curtis, D. J., Brown, F., Wiley, J., Ho, S., Hilton, D. J., Kile, B. T., & Jane, S. M. (2011). ENU Mutagenesis in the Mouse for Identification of Genes Regulating Erythropoiesis: a Mouse Mutant with An Activating Mutation of the KCl Cotransporter, KCC1 Causing Dehydrated Red Cells. In BLOOD Vol. 118 (pp. 313-314). San Diego, CA: AMER SOC HEMATOLOGY.
2011	Schoenwaelder, S. M., Jarman, K., Gardiner, E., Qiao, J. L., White, M. J., Josefsson, E. C., . . . Jackson, S. P. (2011). Bcl-x<sub>l</sub> inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 9 (pp. 63). WILEY-BLACKWELL.
2011	Josefsson, E. C., White, M. J., Schoenwaelder, S. M., Jarman, K., Henley, K. J., Lane, R. M., . . . Kile, B. T. (2011). Elucidating the role of the intrinsic apoptosis pathway in platelet function. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 9 (pp. 11). WILEY-BLACKWELL.
2011	Kile, B. T. (2011). Apoptotic processes in megakaryocytes and platelets. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 9 (pp. 1). WILEY-BLACKWELL.
2011	Josefsson, E. C., James, C., Burnett, D., Debrincat, M. A., Henley, K. J., Lane, R., . . . Kile, B. T. (2011). Megakaryocytes possess functional apoptotic pathways that must be restrained in order to survive and produce platelets. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 9 (pp. 322). WILEY-BLACKWELL.
2010	Ruisi, M. M., Jessica, E., Green, D., Oiyemhonlan, B., Shah, S., Kile, B. T., . . . Bussel, J. B. (2010). Radioulnar Synostosis and Its Hematology and Genetic Associations.. In BLOOD Vol. 116 (pp. 1045). Orlando, FL: AMER SOC HEMATOLOGY.
2010	Mitchell, W. B., Edison, M. N., Pinheiro, M. P., Boulad, N., Psaila, B., Karpoff, M., . . . Bussel, J. B. (2010). The Effect of Eltrombopag on Human Platelet Resistance to Apoptosis: The Role of the Bcl-Xl Pathway.. In BLOOD Vol. 116 (pp. 1044). Orlando, FL: AMER SOC HEMATOLOGY.
2010	Josefsson, E. C., James, C., Henley, K. J., Debrincat, M. A., Rogers, K. L., Dowling, M. R., . . . Kile, B. T. (2010). Megakaryocytes Possess a Functional Intrinsic Apoptosis Pathway That Must Be Restrained In Order to Survive and Produce Platelets. In BLOOD Vol. 116 (pp. 244). Orlando, FL: AMER SOC HEMATOLOGY.
2010	Josefsson, E. C., James, C., Henley, K. J., Debrincat, M., Rogers, K. L., Dowling, M. R., . . . Kile, B. T. (2010). MEGAKARYOCYTES POSSESS A FUNCTIONAL INTRINSIC APOPTOSIS PATHWAY, BUT DO NOT USE IT TO PRODUCE PLATELETS. In EXPERIMENTAL HEMATOLOGY Vol. 38 (pp. S36). Melbourne, AUSTRALIA: ELSEVIER SCIENCE INC.
2010	Ng, P., Hyland, C., Metcalf, D., Carmichael, C. L., Loughran, S. J., DiRago, L., . . . Alexander, W. S. (2010). TRISOMY OF ERG IS REQUIRED FOR MYELOPROLIFERATION IN A MOUSE MODEL OF DOWN SYNDROME. In EXPERIMENTAL HEMATOLOGY Vol. 38 (pp. S24-S25). Melbourne, AUSTRALIA: ELSEVIER SCIENCE INC.
2010	Verhagen, A. M., Goradia, A., Choi, J., Metcalf, D., Kile, B., Collinge, J. E., . . . Starr, R. (2010). LYMPHOPENIA AND DEFECTIVE HEMATOPOIESIS IN THE LAMIN B RECEPTOR DEFICIENT ENU MUTANT MOUSE LYM3. In EXPERIMENTAL HEMATOLOGY Vol. 38 (pp. S10). Melbourne, AUSTRALIA: ELSEVIER SCIENCE INC.
2009	Bishton, M. J., Prince, M., Harrison, S., Martin, B. P., James, C., Kile, B. T., & Johnstone, R. W. (2009). Overcoming Histone Deacetylase Inhibitor Induced Thrombocytopenia Using a Thrombopoietin Mimetic. In BLOOD Vol. 114 (pp. 954). New Orleans, LA: AMER SOC HEMATOLOGY.
2009	James, C., Josefsson, E. C., White, M. J., Henley, K. J., & Kile, B. T. (2009). Deletion of <i>Bcl-X</i> in the Megakaryocyte Compartment Results in Profound Thrombocytopenia Caused by Impaired Platelet Production and Survival. In BLOOD Vol. 114 (pp. 601). New Orleans, LA: AMER SOC HEMATOLOGY.
2009	Hacking, D., Hilton, A., Ip, S., Mukhamedova, N., Meikle, P., Ellis, S., . . . Smyth, I. (2009). A role for Abca12 in regulating terminal differentiation and lipid balance in the developing epidermis. In MECHANISMS OF DEVELOPMENT Vol. 126 (pp. S122-S123). Edinburgh, SCOTLAND: ELSEVIER SCIENCE BV. DOI
2009	Sviridov, D., D'Souza, W., Murphy, A., Mukhamedova, N., Chin-Dusting, J., Hacking, D., . . . Smyth, I. (2009). ABCA12-A NEW REGULATOR OF CELLULAR LIPID METABOLISM. In ATHEROSCLEROSIS SUPPLEMENTS Vol. 10 (pp. 1 page). ELSEVIER IRELAND LTD.
2009	Cordell, P. A., Kile, B. T., Grant, P. J., & Pease, R. J. (2009). Plasma factor XIIIA levels are not maintained by circulating platelets during their lifetime. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 7 (pp. 713-714). ELSEVIER SCIENCE INC.
2009	Schoenwaelder, S. M., Yuan, Y., Josefsson, E. C., White, M. J., Gardiner, E., Andrews, R., . . . Jackson, S. P. (2009). Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 7 (pp. 66). ELSEVIER SCIENCE INC.
2009	Kile, B. T. (2009). The role of the intrinsic apoptosis pathway in platelet life and death. In Journal of Thrombosis and Haemostasis Vol. 7 (pp. 214-217). Boston, MA: WILEY. DOI Scopus61 WoS57 Europe PMC39
2008	Josefsson, E. C., Schoenwaelder, S., White, M., Goschnick, M., Roberts, A. W., Mason, K. D., . . . Kile, B. T. (2008). Platelet Death. In BLOOD Vol. 112 (pp. 1352-1353). San Francisco, CA: AMER SOC HEMATOLOGY.
2007	Tucker, E., O'Donnell, K., Hilton, A. A., Metcalf, D., Greig, K., Sims, N. A., . . . Starr, R. (2007). A novel mutation in the <i>Nfkb2</i> gene generates an NFκB2 'Super repressor'. In CYTOKINE Vol. 39 (pp. 43). San Francisco, CA: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD. DOI
2007	Mason, K. D., Carpinelli, M. R., Fletcher, J. I., Collinge, J. E., Hilton, A. A., Metcalf, D., . . . Huang, D. D. C. S. (2007). The delicate balance between pro survival BCL XL and pro apoptotic BAK determines platelet life span. In EXPERIMENTAL HEMATOLOGY Vol. 35 (pp. 33). Hamburg, GERMANY: ELSEVIER SCIENCE INC. WoS3

2018-2021 DHB Foundation managed by ANZ Trustees. The development of small molecule inhibitors of cell death. $800,000. CIA: BT Kile, CIB: G Lessene.

2017-2021 NHMRC Program Grant No. 1113577: Regulation of Haemopoietic and Immune Cells in Health and Disease. $19,924,985. CIA: WS Alexander, CIB: JJ Babon, CIC: MC Cook, CID: DJ Hilton, CIE: BT Kile, CIF: NA Nicola, CIG: AW Roberts, CIH: CG Vinuesa, CII: IP Wicks.

2015-2018 NHMRC Project Grant No. 1077750: The role of apoptotic caspases in regulating type I interferon production. $761,513. CIA: BT Kile, CIB: M Pellegrini.

2014-2018 NHMRC Principal Research Fellowship No. 1063008. $727,610. CI: BT Kile.

2014-2017 DHB Foundation managed by ANZ Trustees. The development of small molecule inhibitors of cell death. $650,000. CIA: BT Kile, CIB: G Lessene.

2013 Leukaemia Foundation of Australia Research Grant-in-aid. Elucidation of the mechanisms involved in the development of erythromegakaryocytic leukaemia driven by the proto-oncogene ETS-related gene ERG. $100,000. CIA: CL Carmichael, CIB: BT Kile.

2012-2016 NHMRC Program Grant No. 1016647: Molecular regulation of blood cell production and function. $17,100,000. CIA: NA Nicola, CIB: WS Alexander, CIC: DJ Hilton, CID: D Metcalf, CIE: AW Roberts, CIF: JG Zhang, CIG: SE Nicholson, CIH: BT Kile, CII: IP Wicks.

2011-2013 NHMRC Project Grant No. 1002426: Defining the role of Nlrp1 and the inflammasome in host defence and inflammatory disease. $612,561. CIA: BT Kile, CIB: B Croker, CIC: SL Masters.

2009-2011 NHMRC Project Grant No. 545906: The role of the ABCA12 transporter in epidermal lipid homeostasis and atherosclerosis. $496,250. CIA: I Smyth, CIB: D Sviridov, CIC: BT Kile.

2009-2011 NHMRC Project Grant No. 575535: Bcl-2 proteins and the regulation of the megakaryocyte lineage. $399,900. CIA: BT Kile, CIB: C James.

2009-2013 Sylvia & Charles Viertel Foundation Senior Medical Research Fellowship. $975,000. CI: BT Kile.

2008-2010 NHMRC Project Grant No. 516726: Role of the Ets family transcription factor Erg in stem cell function and leukemia development. $397,125 CIA: BT Kile.

2008-2010 NHMRC Project Grant No. 516725: The molecular regulation of platelet life span. $521,000. CIA: BT Kile, CIB: SP Jackson, CIC: AW Roberts.

2007-2011 Cancer Council of Victoria Venture Grant No. Scanning the genome for new drug targets in cancer CIA: WS Alexander, CIB: BT Kile, CIC: A Strasser. 2007-2011. $244,500.

2007-2009 NHMRC Project Grant No. 461247: The genetic control of platelet production and function. $537,000 CIA: BT Kile, CIB: WS Alexander, CIC: HH Nandurkar.

Email: benjamin.kile@adelaide.edu.au

Benjamin Kile

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