Dr Anak Dharmapatni

Postdoctoral Fellow

Health and Medical Sciences Faculty Office

Faculty of Health and Medical Sciences

Dr Anak Dharmapatni completed her PhD in the Discipline of Anatomy and Pathology, School of Medicine, the University of Adelaide in 2007, and MSc in Immunology, Allergy and arthritis, Flinders University in 2002, and MBBS and MD in 1991 and 1987 in Indonesia. Currently she is a post doctoral researcher and academic in the School of Medicine and Dentistry the University of Adelaide. She has obtained grants in arthritis and dental fields, published more than 20 papers and a regular reviewer for many scientific journals. She review grants for funding bodies such as NHMRC and United States-Israel Binational Science Foundation.

My Research
Career
Publications
Grants and Funding
Teaching
Supervision
Contact

My research interests include human diseases associated with auto-immunity, in particular Rheumatoid Arthritis (RA) and systemic sclerosis. However, I am also interested in other forms of arthritis such as osteoarthritis and psoriatic arthritis. In recent years I have focused primarily on chronic inflammation-induced bone loss, such as chronic periodontitis and peri-implant osteolysis. With regards to cellular and molecular processes, my research focuses particularly on apoptosis, autophagy and osteoclast signaling. These are research strengths within the bone and joint lab, discipline of Anatomy and Pathology School of Medical Sciences. These research focuses have great potential for cross disciplinary studies and research collaborations, as demonstrated in a number of our publications.

I have also been successful in attaining various grants since 2012 until recently. These grants were awarded by the Arthritis Australia, the American Society of Bone and Mineral Research (ASBMR) and by the Australian Dental Research Foundation (ADRF).

I have collaborated with various research groups, both nationally and internationally, and continue to do so. Presently, I collaborate with the Colgate Australian Clinical Dental Research Centre, the Orthodontic Unit within the School of Dentistry, the Rheumatology Research Unit at the Repatriation Hospital, and Orthopaedics and Trauma at the University of Adelaide. I have also had international collaborations with Biogen Idec Inc., Cambridge Centre, Cambridge, Department of Medicine Imperial College London (Professor Gavin R. Screaton), Aegera Inc, Canada and SRI International, CA, USA.

I have contributed to my research fields by reviewing numerous scientific journals and grant proposals, and continue to do so. In the past few years I have been invited to review articles for various scientific journals such as Inflammopharmacology, Rheumatology (Oxford), Journal of Inflammation, Journal of Clinical Experimental Immunology, Journal of Histology and Histopathology, Journal of Periodontology, Journal of Cellular Physiology, Journal of Clinical Intervention of Aging, Journal of Human Immunology, Journal of Inflammation Research and Journal Pharma, International Journal of Molecular Sciences (IJMS), Calcified tissue International, PLOS one, Arthritis Research and Therapy. I have been a regular reviewer for the Journal of Periodontal Research, Journal of Human Immunology and Rheumatology (Oxford), which demonstrates my capacity to contribute to worldwide research.

National and international funding bodies have also invited me to review grant proposals. Some of these reviews include grant proposals from the United State-Israel Binational Foundation (BSF) for grant applications for funding the years 2013 and 2014. This demonstrates the recognition of my expertise by an International organization. More recently, I have been invited by the NHMRC to review a project grant for the 2014 project grant funding scheme.

Supervision of high degree research students is an integral part of my research activities. Currently, I am assigned to supervise postgraduate research students in both the School of Medical Sciences and the School of Dentistry.

Appointments

Date Position Institution name

2017 - ongoing Lecturer University of Adelaide

2008 - 2015 Post Doctoral Researcher and casual teaching academic The University of Adelaide

Date	Position	Institution name
2017 - ongoing	Lecturer	University of Adelaide
2008 - 2015	Post Doctoral Researcher and casual teaching academic	The University of Adelaide

Awards and Achievements

Date	Type	Title	Institution Name	Country	Amount
2016	Research Award	Arthritis Australia Project Grant 2016	The University of Adelaide	Australia	AUD$25,000
2015	Research Award	Marion A Simpson grant funded by the State of the Late Marion Alice Simpson.	University of Adelaide	Australia	AUD $25,000

Language Competencies

Language Competency

English Can read, write, speak, understand spoken and peer review
Education

Date Institution name Country Title

2003 - 2007 The University of Adelaide Australia PhD
Research Interests

Arthritis & Rheumatology Dentistry

Language	Competency
English	Can read, write, speak, understand spoken and peer review

Date	Institution name	Country	Title
2003 - 2007	The University of Adelaide	Australia	PhD

Journals

Year	Citation
2018	Williams, B., Dharmapatni, A., & Crotti, T. (2018). Intracellular apoptotic pathways: a potential target for reducing joint damage in rheumatoid arthritis. Inflammation Research, 67(3), 219-231. DOI Scopus21 WoS16 Europe PMC8
2017	Williams, B., Tsangari, E., Stansborough, R., Marino, V., Cantley, M., Dharmapatni, A., . . . Crotti, T. (2017). Mixed effects of caffeic acid phenethyl ester (CAPE) on joint inflammation, bone loss and gastrointestinal inflammation in a murine model of collagen antibody-induced arthritis. Inflammopharmacology, 25(1), 55-68. DOI Scopus11 WoS10 Europe PMC6
2017	Dharmapatni, A., Algate, K., Coleman, R., Lorimer, M., Cantley, M., Smith, M., . . . Crotti, T. (2017). Osteoclast-Associated Receptor (OSCAR) Distribution in the Synovial Tissues of Patients with Active RA and TNF-α and RANKL Regulation of Expression by Osteoclasts In Vitro. Inflammation, 40(5), 1566-1575. DOI Scopus9 WoS8 Europe PMC7
2016	Saad, S., Dharmapatni, A., Crotti, T., Cantley, M., Algate, K., Findlay, D., . . . Haynes, D. (2016). Semaphorin-3a, neuropilin-1 and plexin-A1 in prosthetic-particle induced bone loss. Acta Biomaterialia, 30, 311-318. DOI Scopus20 WoS14 Europe PMC13
2016	Cantley, M., Dharmapatni, A., Algate, K., Crotti, T., Bartold, P., & Haynes, D. (2016). Class I and II histone deacetylase expression in human chronic periodontitis gingival tissue. Journal of Periodontal Research, 51(2), 143-151. DOI Scopus23 WoS17 Europe PMC13
2015	Crotti, T., Dharmapatni, A., Alias, E., & Haynes, D. (2015). Osteoimmunology: major and costimulatory pathway expression associated with chronic inflammatory induced bone loss. Journal of Immunology Research, 2015, 281287-1-281287-13. DOI Scopus95 WoS82 Europe PMC70
2015	Doyle, C., Fitzsimmons, T., Marchant, C., Dharmapatni, A., Hirsch, R., & Bartold, P. (2015). Azithromycin suppresses P. gingivalis LPS-induced pro-inflammatory cytokine and chemokine production by human gingival fibroblasts in vitro. Clinical Oral Investigations, 19(2), 221-227. DOI Scopus32 WoS28 Europe PMC15
2015	Dharmapatni, A., Cantley, M., Marino, V., Perilli, E., Crotti, T., Smith, M., & Haynes, D. (2015). The X-Linked Inhibitor of Apoptosis Protein inhibitor embelin suppresses inflammation and bone erosion in collagen antibody induced arthritis mice. Mediators of Inflammation, 2015(1), 564042-1-564042-10. DOI Scopus22 WoS15 Europe PMC15
2015	Perilli, E., Cantley, M., Marino, V., Crotti, T., Smith, M., Haynes, D., & Dharmapatni, A. (2015). Quantifying not only bone loss, but also soft tissue swelling, in a murine inflammatory arthritis model using micro-computed tomography. Scandinavian Journal of Immunology, 81(2), 142-150. DOI Scopus18 WoS16 Europe PMC13
2015	Zawawi, M., Perilli, E., Stansborough, R., Marino, V., Cantley, M., Xu, J., . . . Crotti, T. (2015). Caffeic accid phenethyl ester abrogates bone resorption in a murine calvarial model of polyethylene particle-induced osteolysis. Calcified Tissue International, 96(6), 565-574. DOI Scopus20 WoS14 Europe PMC12
2015	Zawawi, M., Marino, V., Perilli, E., Cantley, M., Xu, J., Purdue, P., . . . Crotti, T. (2015). Parthenolide reduces empty lacunae and osteoclastic bone surface resorption induced by polyethylene particles in a murine calvarial model of peri-implant osteolysis. Journal of Biomedical Materials Research Part A, 103(11), 3572-3579. DOI Scopus17 WoS13 Europe PMC9
2013	Harvey, G., Fitzsimmons, T., Dharmapatni, A., Marchant, C., Haynes, D., & Bartold, P. (2013). Expression of peptidylarginine deiminase-2 and -4, citrullinated proteins and anti-citrullinated protein antibodies in human gingiva. Journal of Periodontal Research, 48(2), 252-261. DOI Scopus128 WoS110 Europe PMC84
2012	Crotti, T., Dharmapatni, A., Alias, E., Zannettino, A., Smith, M., & Haynes, D. (2012). The immunoreceptor tyrosine-based activation motif (ITAM)-related factors are increased in synovial tissue and vasculature of rheumatoid arthritic joints. Arthritis Research & Therapy, 14(6), 1-13. DOI Scopus46 WoS40 Europe PMC33
2012	Zawawi, M., Dharmapatni, A., Cantley, M., McHugh, K., Haynes, D., & Crotti, T. (2012). Regulation of ITAM adaptor molecules and their receptors by inhibition of calcineurin-NFAT signalling during late stage osteoclast differentiation. Biochemical and Biophysical Research Communications, 427(2), 404-409. DOI Scopus23 WoS20 Europe PMC17
2012	Alias, E., Dharmapatni, A., Holding, C., Atkins, G., Findlay, D., Howie, D., . . . Haynes, D. (2012). Polyethylene particles stimulate expression of ITAM-related molecules in peri-implant tissues and when stimulating osteoclastogenesis in vitro. Acta Biomaterialia, 8(8), 3104-3112. DOI Scopus20 WoS19 Europe PMC16
2012	Upton, A., Holding, C., Dharmapatni, A., & Haynes, D. (2012). The expression of RANKL and OPG in the various grades of osteoarthritic cartilage. Rheumatology International, 32(2), 535-540. DOI Scopus40 WoS35 Europe PMC26
2011	Dharmapatni, A., Smith, M., Crotti, T., Holding, C., Vincent, C., Weedon, H., . . . Haynes, D. (2011). TWEAK and Fn14 expression in the pathogenesis of joint inflammation and bone erosion in rheumatoid arthritis. Arthritis Research & Therapy, 13(2), R51-1-R51-10. DOI Scopus36 WoS31 Europe PMC26
2010	Megson, E., Fitzsimmons, T., Dharmapatni, A., & Bartold, P. (2010). C-reactive protein in gingival crevicular fluid may be indicative of systemic inflammation. Journal of Clinical Periodontology, 37(9), 797-804. DOI Scopus69 WoS57 Europe PMC45
2010	Kataria, N., Bartold, P., Dharmapatni, A., Atkins, G., Holding, C., & Haynes, D. (2010). Expression of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor, fibroblast growth factor-inducible 14 protein (Fn14), in healthy tissues and in tissues affected by periodontitis. Journal of Periodontal Research, 45(4), 564-573. DOI Scopus18 WoS18 Europe PMC10
2010	Lucas, H., Bartold, P., Dharmapatni, A., Holding, C., & Haynes, D. (2010). Inhibition of apoptosis in periodontitis. Journal of Dental Research, 89(1), 29-33. DOI Scopus47 WoS40 Europe PMC31
2009	Dharmapatni, A., Smith, M., Findlay, D., Holding, C., Evdokiou, A., Ahern, M., . . . Haynes, D. (2009). Elevated expression of caspase-3 inhibitors, survivin and xIAP correlates with low levels of apoptosis in active rheumatoid synovium. Arthritis Research & Therapy, 11(1), R13:1-R13:11. DOI Scopus53 WoS52 Europe PMC41
2006	Holding, C., Findlay, D., Stamenkov, R., Neale, S., Lucas, H., Dharmapatni, A., . . . Haynes, D. (2006). The correlation of RANK, RANKL and TNFα expression with bone loss volume and polyethylene wear debris around hip implants. Biomaterials, 27(30), 5212-5219. DOI Scopus112 WoS98 Europe PMC73
2005	Walker, J., Stirling, J., Beroukas, D., Dharmapatni, A., Haynes, D., Smith, M., . . . Roberts-Thomson, P. (2005). Histopathological and ultrastructural features of dermal telangiectasias in systemic sclerosis. Pathology, 37(3), 220-225. DOI Scopus30 WoS26 Europe PMC15
2001	Roberts-Thomson, P. J., Jones, M., Hakendorf, P., Kencana Dharmapatni, A. A., Walker, J. G., MacFarlane, J. G., . . . Ahern, M. J. (2001). Scleroderma in South Australia: epidemiological observations of possible pathogenic significance.. Internal medicine journal, 31(4), 220-229. DOI Europe PMC56

Conference Papers

Year	Citation
2011	Crotti, T. N., Zawawi, M. S., Dharmapatni, A. A., Cantley, M. D., & Haynes, D. R. (2011). INHIBITION OF ITAM ADAPTOR MOLECULES AND THEIR RECEPTORS BY INHIBITION OF CALCINEURIN-NFAT SIGNALLING DURING LATE STAGE HUMAN OSTEOCLAST DIFFERENTIATION. In OSTEOPOROSIS INTERNATIONAL Vol. 22 (pp. S603). Gold Coast, AUSTRALIA: SPRINGER LONDON LTD.
2011	Dharmapatni, A. A. S., Gillard, J. W., Rainsford, K. D., & Haynes, D. R. (2011). REGULATION OF HUMAN OSTEOCLAST ACTIVITY AND APOPTOSIS BY IAP INHIBITORS IN VITRO. In OSTEOPOROSIS INTERNATIONAL Vol. 22 (pp. S603-S604). Gold Coast, AUSTRALIA: SPRINGER LONDON LTD.
2005	Dharmapatni, A. A. S. S. K., Findlay, D. M., Smith, M. D., Evdokiou, A., Chen, P., Screaton, G. R., . . . Haynes, D. R. (2005). Regulating the sensitivity of synovial fibroblasts to trail-induced apoptosis. In ANNALS OF THE RHEUMATIC DISEASES Vol. 64 (pp. 154). Vienna, AUSTRIA: BMJ PUBLISHING GROUP.

Conference Items

Year	Citation
2016	Crotti, T. N., Coleman, R., Dharmapatni, A. A., Weedon, H., Haynes, D. R., Smith, M. D., & Wechalekar, M. D. (2016). EXPRESSION OF OSCAR IN THE SYNOVIUM OF EARLY RA PATIENTS. Poster session presented at the meeting of ANNALS OF THE RHEUMATIC DISEASES. London, ENGLAND: BMJ PUBLISHING GROUP. DOI
2014	Dharmapatni, A., Cantley, M., Marino, V., Perilli, E., Crotti, T., Smith, M., & Haynes, D. (2014). THE X-LINKED INHIBITORY OF APOPTOSIS PROTEIN INHIBITOR, EMBELIN SUPPRESSES INFLAMMATION AND BONE EROSION IN COLLAGEN ANTIBODY INDUCED ARTHRITIS (CAIA) MICE. Poster session presented at the meeting of INTERNAL MEDICINE JOURNAL. WILEY-BLACKWELL.

Date	Project title	Investigators	Funding Body	Amount
2016	Role of autophagy and apoptosis in the pathogenesis of inflammation and bone erosion in Chronic Periodontitis	A Dharmapatni, D Haynes, M Barthold, T Crotti	Australian Dental Research Foundation	17,390
2016	Pharmacologic Modulation of autophagy and apoptosis in Collagen Antibody Induced Arthritis model	A Dharmapatni, T Crotti, D Haynes	Arthritis Australia State/Territory Affiliate Arthritis SA	25,000
2015	Abrogating bone loss and inflammation in a mouse model of inflammatory arthritis	T Crotti, A Dharmapatani, R Gibson, E Perilli	Arthritis Australia Marion A Simpson Grant	25,000
2015	OSCAR A Serum Marker of Joint Erosion Enabling Treatment Modification	T Crotti, A Dharmapatani, M Smith, M Wechalekar	American Society for Bone and Mineral Research	50,000 USD
2014	Inhibiting autophagy to allow apoptosis to prevent joint damage in Rheumatoid Arthritis	A Dharmapatani	Arthritis Australia	10,000
2012	Investigating the potential use of IAP inhibitors for treatments of rheumatoid arthritis	A Dharmapatani	Arthritis Australia	15,000
2012	The Role of RUNX2 and VEGF during healing of periodontal ligament following hypothermal insult	A Dharmapatani (CIC)	Australian Dental Research Foundation	5,000
2010	Expression of Rheumatoid factor citrullinated protein and anti-citrullinated protein antibodies in normal and inflamed gingival tissue	A Dharmapatani (CID)	Australian Dental Research Foundation	5,000

2016 - Lecturer Discipline of Anatomy and Pathology School of Medicine, Faculty of Health Sciences, The University of Adelaide

2014 - 2015 Tutor for Small Group discovery Experience (SGDE) part of Biology of Disease 2 (BOD2) for Bachelor of Health sciences

2009 - Tutor for Dental and Clinical Science and Practice (DSP1 and 2) topics for 1^st and 2^nd year for Dentistry students at the University of Adelaide

2007 - Guest lecturer of Biology of Human Disease (BOD2) with topic: “Bone and joint diseases” and “Infections in the developing countries”

2015 Guest lecturer for ENGR 7702, School of Computer Science, Engineering and Mathematics

2013 - 2014 Tutor for Human Biology, Anatomy and Physiology (Human Biology 1B) for Bachelor of Health Sciences

2007 - 2013 Demonstrator for Resource Sessions (integrated medical sciences including gross anatomy, histology and pathology) for 1^st and 3^rd year for Medicine students at the University of Adelaide

2010 Demonstrator for NURS 1102 (Anatomy and Physiology for Nursing) topic within the Nursing School at Flinders University

1996 - 2000 Lecturer Clinical Pathology for fifth semester/3rd year in the Faculty of Medicine at Udayana University, Bali, Indonesia

1996 - 2000 Lecturer Clinical Pathology for Bachelor of Nursing students at Udayana University, Bali Indonesia

Past Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2016 - 2019	Co-Supervisor	Pharmacological Modulation of Inflammation, Bone Loss and Pain in a Murine Model of Inflammatory Arthritis	Doctor of Philosophy	Doctorate	Full Time	Dr Bonnie Williams
2013 - 2015	Co-Supervisor	An investigation into the role of RANKL and sclerostin in dentoalveolar ankylosis using a rat model	Doctor of Clinical Dentistry	Doctorate	Full Time	Dr Shelley Joanne Coburn
2011 - 2015	Co-Supervisor	Targeting NF-kappaB and NFATc1 signalling to inhibit bone resorption in peri-prosthetic osteolysis	Doctor of Philosophy	Doctorate	Full Time	Mr Muhamad Syahrul Fitri Zawawi
2010 - 2014	Co-Supervisor	Osteoclast-associated Intracellular ITAM Signalling Molecules in Human Peri-implant Osteolysis and Rheumatoid Arthritis	Doctor of Philosophy	Doctorate	Full Time	Mr Ekram Alias
2010 - 2011	Co-Supervisor	The Role of the Osteocyte in Orthodontic Tooth Movement in the Rat Dento-Alveolar Complex	Doctor of Clinical Dentistry	Doctorate	Full Time	Dr Dinesh Sanmuganathan
2010 - 2012	External Supervisor	Insight into the Role of Periodontal Ligament Associated Protein 1 Asporin in the Maintenance of the Periodontal Ligament Using a Rat Ankylosis Model	Doctor of Clinical Dentistry	Doctorate	Full Time	Dr Wayne Chuo-Wei Chen
2010 - 2013	Co-Supervisor	Expression of Runt Related Transcription Factor 2 and Vascular Endothelial Growth Factor in the Pulp, Periodontal Ligament and Alveolar Bone: An Immunohistochemical Study Using a Rat Ankylotic Model	Doctor of Clinical Dentistry	Doctorate	Full Time	Dr Trudy Ann Stewart

Position: Postdoctoral Fellow
Phone: 83135986
Email: a.dharmapatni@adelaide.edu.au
Fax: 83134408
Campus: North Terrace
Building: Helen Mayo North, floor 3
Org Unit: Medical Sciences

Dr Anak Dharmapatni

Appointments

Awards and Achievements

Language Competencies

Education

Research Interests

Journals

Conference Papers

Conference Items

Past Higher Degree by Research Supervision (University of Adelaide)

Connect With Me

External Profiles