Gustavo Ferlini Agne

Dr Gustavo Ferlini Agne

Equine Lecturer

School of Animal and Veterinary Science

Faculty of Sciences, Engineering and Technology

Gustavo is a Large Animal Internal Medicine Specialist and lecturer in Equine Internal Medicine in the School of Animal and Veterinary Science at The University of Adelaide. After graduating from the Federal University of Rio Grande do Sul (UFRGS - Brazil), Gustavo worked as an equine practitioner in south of Brazil with a focus on equine reproduction. Afterwards, Gustavo completed two equine rotating internships in California, USA and an equine medicine fellowship at Hagyard Equine Medical Institute prior to commencing a specialty training programme in Large Animal Internal Medicine at Auburn University. Gustavo also attained a Master of Science degree at Auburn University studying the pharmacokinetics and pharmacodynamics of a novel oral diuretic in horses. Following this, he attained board-certification with large animal internal medicine specialist status with the American College of Veterinary Internal Medicine and commenced his academic career at The University of Adelaide. Gustavo is currently undertaking a PhD investigating the welfare impact and aspects of non-response to therapy in horses with Equine Gastric Ulceration. Gustavo has a passion for all aspects of internal medicine, including pharmacology, gastroenterology, endocrinology, neonatology, cardiorespiratory, ophthalmology as well as treatment and management of infectious diseases.

Dr. Gustavo's research is centered around improved diagnostic intervention and clinical approaches in veterinary practice with an ultimate goal of optimizing treatment outcome and animal welfare. Main research areas include gastroenterology and pharmacology. 

Current and previous projects include:

- Investigation of drug metabolism variability in horses - with a focus on treatment of Equine Gastric Ulceration Syndrome. 

- Investigation of pain biomarkers and pain scales in horses. Specifically, in horses suffering from Equine Gastric Ulcer Syndrome. 

- Investigation of biomarkers for screening of surgical lesions and determination of survival in horses with abdominal discomfort (colic)

- Antimicrobial stewardship - with a focus on pharmacokinetics of antimicrobials and reported MIC from common pathogens in equine veterinary medicine. 

- Pharmacokinetic and pharmacodynamic studies of novel pharmaceuticals in large animal veterinary medicine

 

 

  • Journals
    Year Citation
    2024 Ferlini Agne, G., Kapusniak, A. E., Wooldridge, A. A., & Jung, S. W. (2024). Clinical effect of torsemide in a horse with congestive heart failure and atrial fibrillation.. J Equine Vet Sci, 133, 105001.
    DOI
    2024 Gomez, D. E., Kopper, J. J., Byrne, D. P., Renaud, D. L., Schoster, A., Dunkel, B., . . . Toribio, R. E. (2024). Treatment approaches to horses with acute diarrhea admitted to referral institutions: A multicenter retrospective study. PLoS ONE, 19(11 November), 19 pages.
    DOI
    2024 Horner, S., Agne, G. F., Byrne, D. P., Bain, M. E., Lynch, B. M., Gow, W. R., & Verdegaal, E. L. J. M. M. (2024). Case series report: Equine coronavirus in Australia. Australian Veterinary Journal, 7 pages.
    DOI
    2024 Ferlini Agne, G., Adamson, K., McGlinchey, L., Kravchuk, O., Santos, L., & Schumacher, J. (2024). Comparison of a hand-held high-end resolution infrared thermography (FLIR P640) and a smartphone infrared thermographic device (FLIR One) for the assessment of skin surface temperature after anaesthetising the median nerve in Healthy horses.. PLoS One, 19(8), e0309603-1-e0309603-17.
    DOI
    2024 Ferlini Agne, G., Carr, A. M. N., Kirkwood, R. N., & Petrovski, K. R. (2024). Assisting the Learning of Clinical Reasoning by Veterinary Medical Learners with a Case Example. Veterinary Sciences, 11(9), 11090433-1-11090433-24.
    DOI Europe PMC1
    2024 Gomez, D., Arroyo, L. G., Schoster, A., Renaud, D. L., Kopper, J. J., Dunkel, B., . . . Toribio, R. E. (2024). Diagnostic approaches, aetiological agents and their associations with short-term survival and laminitis in horses with acute diarrhoea admitted to referral institutions. Equine Veterinary Journal, 56(5), 959-969.
    DOI WoS1 Europe PMC3
    2024 Gomez, D. E., Dunkel, B., Renaud, D. L., Arroyo, L. G., Schoster, A., Kopper, J. J., . . . Toribio, R. E. (2024). Survival rates and factors associated with survival and laminitis of horses with acute diarrhoea admitted to referral institutions. EQUINE VETERINARY JOURNAL, 56(5), 970-981.
    DOI Europe PMC2
    2023 Ferlini Agne, G., May, B. E., Lovett, A., Simon, O., Steel, C., Santos, L., . . . Franklin, S. (2023). Horse Grimace Scale Does Not Detect Pain in Horses with Equine Gastric Ulcer Syndrome. Animals, 13(10), 12 pages.
    DOI Scopus4 Europe PMC1
    2023 Ferlini Agne, G., Somogyi, A. A., Sykes, B., Knych, H., & Franklin, S. (2023). Identification and kinetics of microsomal and recombinant equine liver cytochrome P450 enzymes responsible for in vitro metabolism of omeprazole.. Biochem Pharmacol, 214, 1-7.
    DOI Scopus1
    2023 Flood, J., Byrne, D., Bauquier, J., Agne, G. F., Wise, J. C., Medina-Torres, C. E., . . . Stewart, A. J. (2023). Right dorsal colitis in horses: A multicenter retrospective study of 35 cases. Journal of Veterinary Internal Medicine, 37(6), 2535-2543.
    DOI Scopus1 Europe PMC1
    2023 Ferlini Agne, G., & Feary, D. (2023). Nervous System Disorders Section 5: Pathophysiology and Treatment of Central Nervous System Trauma in the Foal. Unknown Journal, 1.
    Scopus1
    2022 Easther, R., Manthorpe, E., Woolford, L., Kawarizadeh, A., Hemmatzadeh, F., & Ferlini Agne, G. (2022). Eosinophilic Inflammation and Equine Herpesvirus-1 Associated With Haemorrhagic Cystitis in a Horse. Case Report. Journal of Equine Veterinary Science, 119, 6 pages.
    DOI Scopus3 WoS1 Europe PMC1
    2021 Pedler, C., Nath, L., Agne, G. F., Hebart, M., & Franklin, S. (2021). Heritability estimates of atrial fibrillation in Thoroughbred racehorses in Hong Kong and Australia. Journal of Veterinary Cardiology, 36, 8 pages.
    DOI Scopus2 WoS1 Europe PMC1
    2021 Burbery, K., Simon, O., Woolford, L., & Ferlini Agne, G. (2021). Bilateral thyroid adenomas in an alpaca. Journal of Veterinary Internal Medicine, 35(6), 2937-2942.
    DOI Europe PMC1
    2019 McGlinchey, L., Agne, G., Passler, T., Cole, R., & Schumacher, J. (2019). An Objective Assessment of the Effect of Anesthetizing the Median Nerve on Lameness Caused by Pain in the Cubital Joint.. Journal of equine veterinary science, 75, 9-13.
    DOI Scopus2 Europe PMC1
    2018 Agne, G. F., Stockler, R. M., Passler, T., Maxwell, H., & Cole, R. (2018). Successful surgical resolution of a ceco-cecal intussusception in a 15-month-old Angus heifer.. The Canadian veterinary journal = La revue veterinaire canadienne, 59(10), 1071-1074.
    Scopus3 WoS2 Europe PMC2
    2018 Ferlini Agne, G., Jung, S. W., Wooldridge, A. A., Duran, S. H., Ravis, W., & Toribio, R. (2018). Pharmacokinetic and pharmacodynamic properties of orally administered torsemide in healthy horses. Journal of Veterinary Internal Medicine, 32(4), 1428-1435.
    DOI Scopus5 Europe PMC1
    2010 Neves, A. P., Bustamente-Filho, I. C., Wolf, C. A., Castro, F. S., Richter, G., Motta, F. F., . . . Mattos, R. C. (2010). Some aspects of peripartum, neonate and foal heat in mini pony mares. Pferdeheilkunde, 26(1), 36-38.
    DOI
    - Carr, A. M. N., Ferlini Agne, G., Kirkwood, R. N., & Petrovski, K. R. (n.d.). Teaching Clinical Reasoning to Veterinary Medical Learners with a Case Example. Encyclopedia, 4(2), 753-775.
    DOI

  • Book Chapters
    Year Citation
    2024 Agne, G. F., & Feary, D. (2024). Section VI: Traumatic Brain and Spinal Cord Injury in the Foal. In Equine Neonatal Medicine (pp. 858-885).
    2024 Feary, D., & Agne, G. F. (2024). Section V: Pathophysiology and Treatment of Central Nervous System Trauma in the Foal. In Equine Neonatal Medicine (pp. 831-857).
    2023 Ferlini Agne, G., & Feary, D. (2023). Nervous System Disorders Section 5: Pathophysiology and Treatment of Central Nervous System Trauma in the Foal. In D. Wong (Ed.), Equine Neonatal and Perinatal Medicine and Surgery (the “Work”) (Vol. 1, 1 ed.).

  • Conference Papers
    Year Citation
    2022 Flood, J., byrne, D., Bauquier, J., Ferlini Agne, G., Wise, J., Medina-Torres, C. E., . . . Stewart, A. J. (2022). Right dorsal colitis in horses: a retrospective study of 35 cases.. In ACVIM Forum Research Abstract Proceedings. Virtual.
    2021 Ferlini Agne, G., Franklin, S. A. M. A. N. T. H. A., & Knych, H. (2021). Preliminary investigation of equine recombinant cyp450 enzymes responsible for in vitro metabolism of omeprazole. In European College of Equine Internal Medicine Online Congress. Virtual.
    2021 Pedler, C., Nath, L., Ferlini Agne, G., Hebart, M., & Franklin, S. A. M. A. N. T. H. A. (2021). Heritability estimates of atrial fibrillation in Thoroughbred racehorses. In European College of Equine Internal Medicine Virtual Congress. Online.
    2018 McGlinchey, L., Ferlini Agne, G., Passler, T., Cole, R., & Schumacher, J. (2018). An objective assessment of the effect of desensitizing the median nerve on lameness originating from the cubital joint.. In 10.1055/s-0038-1668222. Snowmass Village, CO.
    2018 Byrne, B. A., Whitaker, D. M., Struve, C., Estell, K., Aleman, M., Groover, E. S., . . . Soto, E. (2018). Characterization of hypermucoviscous/hypervirulent Klebsiella pneumoniae isolated from horses with severe pneumonia.. In https://doi.org/10.1111/jvim.15319. Seatle, WA.
    DOI
    2017 Ferlini Agne, G., Jung, S., Wooldridge, A. A., Ravis, W., & Duran, S. (2017). Pharmacokinetic and biochemical profiles after single administration of oral torsemide in healthy horses.. In https://doi.org/10.1111/jvim.14778. National Harbor, MD.
    DOI
    2017 Ferlini Agne, G., Jung, S., Wooldridge, A., Duran, D., & Ravis, W. (2017). Pharmacodynamic properties of oral torsemide in healthy horses.. In ACVIM Forum Research Abstract Proceedings. National Harbor, MD.
    DOI

  • Conference Items
    Year Citation
    2022 Ferlini Agne, G. (2022). Right dorsal colitis in horses: a retrospective study of 35 cases. Oral presentation. Jordan Flood, David Byrne, Jennifer Bauquier, Gustavo Ferlini Agne, Jessica C Wise, Carlos E Medina-Torres, Olivia Sullivan, Allison J Stewart,. Poster session presented at the meeting of Bain Fallon Memorial Lectures. Melbourne, Australia.
    2022 Ferlini Agne, G. (2022). Right dorsal colitis in horses: a retrospective study of 35 cases. Oral presentation. Jordan Flood, David Byrne, Jennifer Bauquier, Gustavo Ferlini Agne, Jessica C Wise, Carlos E Medina-Torres, Olivia Sullivan, Allison J Stewart,. Poster session presented at the meeting of Bain Fallon Memorial Lectures. Melbourne, Australia.
    2022 Ferlini Agne, G. (2022). Agne, G.F. ” Preliminary investigation of pain related to equine gastric ulceration & in vitro metabolism of omeprazole in horses.. Poster session presented at the meeting of Australian and New Zealand College of Veterinary Scientists (ANZVCS) Science Week Conference – Equine Chapter. Gold Coast, QLD, AUS.
    2019 Ferlini Agne, G. (2019). The effects of orally administered torsemide on electrolyte fractional excretion and serum symmetric dimethylarginine (SDMA) in healthy horses. Poster session presented at the meeting of European College of Equine Internal Medicine Congress. Valencia, Spain.

2020-2022 - Cat 1 0006007942: RIRDC - Open Call Research and Development Projects: Can iso-PGs indicate the need for surgery and predict survival in colic horses? Emilie Mas; Ferlini Agne, Gustavo; Noschka, Erik; Du Preez, Surita; Labens, Raphael; Total amount awarded: $40,833 AUD

 

  • Funding scheme: FND000706: Fight Food Waste CRC Project
  • Description: Bioactive compounds in unripe bananas may confer a variety of health benefits. Studies have identified high levels of antioxidants and resistant starch which may be beneficial for gastrointestinal health. They have also been shown to have anti-ulcerogenic properties in human and rodent models of disease. Approximately 60-100% of strenuously exercising horses are affected by equine gastric ulceration syndrome (EGUS). Exercise-induced oxidative stress is also identified in athletic horses. Antioxidant supplementation is recommended to restore the oxidant/antioxidant balance. This project aims to develop a nutraceutical profile of a dried green banana supplement (produced by Banana Feeds Australia) and identify potential equine health applications. This will be achieved by: Objective 1: Developing a profile of biologically active compounds in the dried green banana supplement. Objective 2: Determining the effects of a dried green banana supplement on gastrointestinal health by 1) investigating its effectiveness as an EGUS preventative and 2) investigating its effect on faecal microbiome and total antioxidant status.
  • Funder name: Fight Food Waste CRC
  • Funder reference: 2.3.1-2

Reporting dates: 09 Apr 2020 to 09 Apr 2021

2020-2021 - Cat 2-4 0006009461: Fight Food Waste CRC Project: Livestock and Equine Scoping Study; Franklin, Samantha; Weaver, Sarah Jane; Nayar, Sasi; Verdegaal, Elisabeth Johanna Martina Magdelena; Hebart, Michelle Leanne; Caetano, Mariana; DuPreez, Surita; Ferlini Agne, Gustavo; Total amount awarded: $100,000 AUD

2020 - Chief Investigator - UofA Collaboration Grant Scheme: Agne G.F., Jung S., Wooldridge A.A., Duran SH., Ravis W., Lopes M., “The effects of orally administered torsemide on electrolyte fractional excretion and serum symmetric dimethylarginine (SDMA) in healthy horses”. ECEIM Congress, Valencia, Spain, November 2019. (Published Research Abstract - Platform). Total amount awarded: $4000 AUD matched by additional $4000 by UC Davis California.

2019 - Chief Investigator - UofA Travel Grant Scheme: Agne G.F., Jung S., Wooldridge A.A., Duran SH., Ravis W., Lopes M., “The effects of orally administered torsemide on electrolyte fractional excretion and serum symmetric dimethylarginine (SDMA) in healthy horses”. ECEIM Congress, Valencia, Spain, November 2019. (Published Research Abstract - Platform). Total amount awarded: $2000 AUD

Basic principles, concepts and approaches of equine veterinary diseases and disorders to clinical and preclinical students in the doctorate of veterinary medicine (DVM), veterinary technology and animal sciences programs. 

  • Other Supervision Activities
    Date Role Research Topic Location Program Supervision Type Student Load Student Name
    2020 - 2021 Principal Supervisor Pain in horses with Equine Gastric Ulcer Syndrome University of Adelaide Animal Sciences Honours Full Time Bridget May
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