Thomas Fallon
School of Physics, Chemistry and Earth Sciences
Faculty of Sciences, Engineering and Technology
The Fallon group works on the chemistry of shape-shifting molecules. These intriguing dynamic systems have no permanent structure and exist in constant metamorphosis. We develop new synthetic and analytical methods, and are applying these systems in molecular devices and medicinal chemistry.
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Journals
Year Citation 2025 Li, T., Datson, Z., Birvé, A. P., Ciampi, S., Fallon, T., Kosov, D. S., . . . Darwish, N. (2025). Toward Piezoresistive Devices That Exploit Bullvalene's Structural Versatility.. Langmuir, 41(8), 5410-5418.
2023 Ottonello, A., Wyllie, J. A., Yahiaoui, O., Sun, S., Koelln, R. A., Homer, J. A., . . . Moses, J. E. (2023). Shapeshifting bullvalene-linked vancomycin dimers as effective antibiotics against multidrug-resistant gram-positive bacteria.. Proceedings of the National Academy of Sciences of the United States of America, 120(15), e2208737120.
Scopus12 WoS1 Europe PMC82023 Smedley, C. J., Giel, M. -C., Fallon, T., & Moses, J. E. (2023). Ethene-1,1-disulfonyl Difluoride (EDSF) for SuFEx Click Chemistry: Synthesis of SuFExable 1,1-Bissulfonylfluoride Substituted Cyclobutene Hubs.. Angew Chem Int Ed Engl, 62(30), e202303916.
Scopus8 Europe PMC32023 Reimers, J. R., Li, T., Birvé, A. P., Yang, L., Aragonès, A. C., Fallon, T., . . . Darwish, N. (2023). Controlling piezoresistance in single molecules through the isomerisation of bullvalenes. Nature Communications, 14(1), 6089-1-6089-13.
Scopus10 Europe PMC52022 Birve, A., Patel, H. D., Price, J. R., Bloch, W. M., & Fallon, T. (2022). Guest-dependent isomer convergence of a permanently fluxional coordination cage. Angewandte Chemie International Edition, 61(9), e202115468-1-e202115468-6.
Scopus28 WoS14 Europe PMC142022 Patel, H. D., Gaggl, S., Pašteka, L. F., & Fallon, T. (2022). Ambimodal Pericyclic Rearrangements of Dialkenyl-Bullvalenes Give Tetrahydro-1,8-ethenoheptalenes. Organic Letters, 24(1), 319-323.
Scopus3 WoS1 Europe PMC12022 Patel, H. D., & Fallon, T. (2022). Two Steps to Bicyclo[4.2.0]octadienes from Cyclooctatetraene: Total Synthesis of Kingianic Acid A. Organic Letters, 24(12), 2276-2281.
Scopus5 WoS2 Europe PMC32022 Zur Bonsen, A. B., Peralta, R. A., Fallon, T., Huang, D. M., & George, J. H. (2022). Intramolecular Tricarbonyl-Ene Reactions and α-Hydroxy-β-Diketone Rearrangements Inspired by the Biosynthesis of Polycyclic Polyprenylated Acylphloroglucinols. Angewandte Chemie International Edition, 61(34), 1-10.
Scopus7 WoS1 Europe PMC22022 Ottonello, A., Wyllie, J. A., Yahiaoui, O., Murray, E., Williams, P., Bolla, J. R., . . . Moses, J. E. (2022). Shapeshifting Antibiotics: Bullvalene Linked Vancomycin Dimers are Effective Against Multidrug-Resistant Gram-Positive Bacteria.
2021 Yahiaoui, O., Patel, H. D., Chinner, K. S., Pašteka, L. F., & Fallon, T. (2021). Stereomutation of Substituted Bullvalenes.. Organic letters, 23(4), 1157-1162.
Scopus6 WoS5 Europe PMC32021 Shadfar, Z., Yahiaoui, O., Collier, T. A., Fallon, T., & Allison, J. R. (2021). Illustration of a computational pipeline for evaluating cyclodextrin host-guest complex formation through conformational capture of bullvalene.. The Journal of chemical physics, 154(15), 1-15.
Scopus4 WoS32020 Lording, W. J., Fallon, T., Sherburn, M. S., & Paddon-Row, M. N. (2020). The simplest Diels-Alder reactions are not: Endo -selective. Chemical Science, 11(43), 11915-11926.
Scopus33 WoS20 Europe PMC102020 Patel, H. D., Tran, T. -H., Sumby, C. J., Pašteka, L. F., & Fallon, T. (2020). Boronate Ester Bullvalenes. Journal of the American Chemical Society, 142(8), 3680-3685.
Scopus20 WoS11 Europe PMC92020 Guo, Y., Empel, C., Pei, C., Atodiresei, I., Fallon, T., & Koenigs, R. M. (2020). Photochemical Cyclopropanation of Cyclooctatetraene and (Poly-)unsaturated Carbocycles.. Organic letters, 22(13), 5126-5130.
Scopus36 WoS22 Europe PMC82020 Peralta, R. A., Huxley, M. T., Evans, J. D., Fallon, T., Cao, H., He, M., . . . Doonan, C. J. (2020). Highly active gas phase organometallic catalysis supported within metal-organic framework pores. Journal of the American Chemical Society, 142(31), 13533-13543.
Scopus46 WoS34 Europe PMC112020 Vieira de Castro, T., Yahiaoui, O., Peralta, R. A., Fallon, T., Lee, V., & George, J. H. (2020). Biomimetic synthesis enables the structure revision of littordials E and F and drychampone B. Organic Letters, 22(20), 8161-8166.
Scopus19 WoS14 Europe PMC52020 Yahiaoui, O., Almass, A., & Fallon, T. (2020). Total synthesis of endiandric acid J and beilcyclone A from cyclooctatetraene. CHEMICAL SCIENCE, 11(35), 9421-9425.
Scopus10 WoS8 Europe PMC42019 Patel, H., Tran, T. H., Sumby, C., Pašteka, L., & Fallon, T. (2019). Boronate Ester Bullvalenes.
2019 Murray, L. A. M., Fallon, T., Sumby, C. J., & George, J. H. (2019). Total synthesis of naphterpin and marinone natural products. Organic Letters, 21(20), 8312-8315.
Scopus24 WoS16 Europe PMC52019 Yahiaoui, O., Pašteka, L. F., Blake, C. J., Newton, C. G., & Fallon, T. (2019). Network Analysis of Substituted Bullvalenes.. Org Lett, 21(23), 9574-9578.
Scopus13 WoS10 Europe PMC82018 Yahiaoui, O., Pašteka, L., Judeel, B., & Fallon, T. (2018). Synthesis and Analysis of Substituted Bullvalenes. Angewandte Chemie - International Edition, 57(10), 2570-2574.
Scopus33 WoS21 Europe PMC152017 Fallon, T., & Meek, T. (2017). Simplified "no-D" NMR Methods for Routine Analysis and Organometallic Reagent Concentration Determination. Organic Letters, 19(21), 5752-5755.
Scopus2 WoS12016 Saglam, M. F., Fallon, T., Paddon-Row, M. N., & Sherburn, M. S. (2016). Discovery and computational rationalization of diminishing alternation in [n]dendralenes. Journal of the American Chemical Society, 138(3), 1022-1032.
Scopus27 WoS19 Europe PMC72015 Fallon, T., & Oestreich, M. (2015). A Constellation of Deuterium-Labeled Silanes as a Simple Mechanistic Probe not Requiring Absolute Configuration Determination. Angewandte Chemie - International Edition, 54(42), 12488-12491.
Scopus24 WoS20 Europe PMC132015 Pareek, M., Fallon, T., & Oestreich, M. (2015). Platinum(0)-Catalyzed Indolyne Insertion into Bis(pinacolato)diboron Followed by Site-Selective Suzuki-Miyaura Cross-Coupling. Organic Letters, 17(9), 2082-2085.
Scopus25 WoS17 Europe PMC82015 Mackay, E., Newton, C., Toombs-Ruane, H., Lindeboom, E., Fallon, T., Willis, A., . . . Sherburn, M. (2015). [5]Radialene. Journal of the American Chemical Society, 137(46), 14653-14659.
Scopus28 WoS24 Europe PMC52014 Fallon, T., Willis, A. C., Paddon-Row, M. N., & Sherburn, M. S. (2014). Furanodendralenes. The Journal of Organic Chemistry, 79(7), 3185-3193.
Scopus16 WoS15 Europe PMC62014 Redies, K. M., Fallon, T., & Oestreich, M. (2014). En route to stable all-carbon-substituted silylenes: Synthesis and reactivity of a bis(α-spirocyclopropyl)silylene. Organometallics, 33(13), 3235-3238.
Scopus12 WoS82012 Fallon, T., Willis, A. C., Rae, A. D., Paddon-Row, M. N., & Sherburn, M. S. (2012). β-Oligofurans. Chemical Science, 3(6), 2133-2137.
Scopus24 WoS232011 Toombs-Ruane, H., Osinski, N., Fallon, T., Wills, C., Willis, A. C., Paddon-Row, M. N., & Sherburn, M. S. (2011). Synthesis and applications of tricarbonyliron complexes of dendralenes. Chemistry - An Asian Journal, 6(12), 3243-3250.
Scopus16 WoS13 Europe PMC42010 Fallon, T., Robinson, D. E. J. E., Willis, A. C., Paddon-Row, M. N., & Sherburn, M. S. (2010). Double dehydro-diels-alder reactions of 1,5-dien-3-ynes. Chemistry - A European Journal, 16(3), 760-765.
Scopus8 WoS7 Europe PMC2
New Zealand Royal Society Marsden Fast-Start grant 2016-2019.
- Chemical Kinetics (1st year)
- Purification and Analytical Chemistry (2nd year)
- Aromatic chemistry (2nd year)
- Bioorganic chemistry (2nd year)
- Stereoselective synthesis (3rd year)
- Pericyclic Chemistry (Honours)
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2025 Co-Supervisor Biomimetic Synthesis of Natural Products Doctor of Philosophy Doctorate Full Time Mr Matthew Alexander Coleman 2025 Principal Supervisor Chemical Synthesis of Shape-Shifting Cyclic Peptides Master of Philosophy Master Full Time Mr Qiyuan Tao 2025 Principal Supervisor PNA and peptide based development of medicinally active molecular switches Doctor of Philosophy Doctorate Full Time Ms Rachel Josephine Tishler 2024 Principal Supervisor Synthesis and application of substituted bullvalenes Doctor of Philosophy Doctorate Full Time Mr Andre Pierson Birve 2024 Co-Supervisor Developing new methods for drug release targeting cell surface receptor density. Doctor of Philosophy Doctorate Full Time Ms Maya Liza Doyle -
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2022 - 2022 Co-Supervisor Biomimetic Synthesis Enables the Structural Revision of Natural Products Master of Philosophy Master Full Time Mr Tomas Mendes Gouveia Vieira deCastro 2020 - 2023 Principal Supervisor Diels-Alder and Electrocyclic Strategies in Complex Molecule Synthesis Doctor of Philosophy Doctorate Full Time Mr Isuru Dissanayake Mudiyanselage 2020 - 2024 External Supervisor The Application of Peroxygenase P450 Enzymes as Selective Oxidation Catalysts Doctor of Philosophy Doctorate Full Time Ms Jinia Akter 2019 - 2023 Co-Supervisor Biomimetic Total Synthesis of Meroterpenoid Natural Products Doctor of Philosophy Doctorate Full Time Miss Sarah Alexandra French 2018 - 2022 Principal Supervisor Synthesis and Applications of Substituted Bullvalenes and The Synthesis of Bicyclo[4.2.0]octadiene Derived Natural Products Doctor of Philosophy Doctorate Full Time Mr Harshal Deepak Patel 2018 - 2020 Co-Supervisor Synthesis and Network Analysis of Substituted Bullvalenes and the Total Synthesis of Endiandric Acid J and Beilcyclone A Doctor of Philosophy Doctorate Full Time Mr Ossama Yahiaoui 2018 - 2023 Co-Supervisor Small Molecules Targeting Novel Mycobacterium tuberculosis Drug Targets Doctor of Philosophy Doctorate Full Time Mr Nicholas Charles Schumann
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