Joanne Tan

School of Medicine

College of Health

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


Joanne is a senior postdoctoral researcher at the South Australian Health and Medical Research Institute where she leads the miRNAs and Diabetes research programs in the Vascular Research Centre, Heart & Vascular Health Program, Lifelong Health Theme. She is also an Affiliate Senior Lecturer at The University of Adelaide. She is a vascular biologist with interests and expertise in angiogenesis and diabetes-impaired cellular mechanisms. She completed her PhD at The University of Sydney in 2007 where she looked at the role of adipocyte differentiation in the development of metabolic syndrome. She then began her postdoctoral training at the Heart Research Institute where she explored the vasculoprotective effects of high-density lipoproteins (HDL), with a particular focus on the role of HDL in angiogenesis-associated diseases. Her current research interests include exploring novel therapeutic targets that will alleviate vascular complications associated with diabetes.

Research Program: The prevalence of diabetes and its associated vascular complications are on the rise. Despite advances in management, many patients remain refractory to current treatments. As diabetes and its vascular complications impose a huge health and economic burden, highlighting a significant unmet clinical need for the discovery of new biomarkers that detect severity of disease and the development of novel treatments. MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression by targeting mRNAs causing either partial or complete translational repression. miRNAs have emerged as versatile targets for clinical therapeutics in complex multifaceted diseases such as diabetes and are the leading biopharmaceuticals in next generation medicine. miRNAs are stable in the circulation and studies have shown that miRNA profiles change with severity of disease. We have recently identified that the miRNA, miR-181c has novel anti-angiogenic properties and is important in diabetes-impaired angiogenic responses. Our group are seeking to explore whether miR-181c and other novel miRNA targets can act as both clinical biomarkers and therapeutic targets to alleviate the burden of diabetic vascular complications.

Research Project 1:

Title:  miRNAs as clinical biomarkers for diabetic vascular complications

Project description: Circulating miRNAs have emerged as novel biomarkers and HDL miRNA content differs with disease states. Our preliminary data suggest that elevated HDL-bound miR-181c levels may be a novel biomarker reflective of diabetic vascular complications and provide insight into the extent of HDL functionality which may contribute to the impaired responses in diabetes seen in the Aboriginal population. Whether this biomarker is unique to the Aboriginal population or if the non-Indigenous population also have elevated HDL-miR-181c levels remains to be determined. We seek to assess whether circulating and HDL-bound miRNAs can serve as diagnostic biomarkers reflective of disease severity in different populations. We will comprehensively elucidate miRNA profiles in individuals without diabetes, with diabetes and with diabetes-associated vascular complications. Functional angiogenic capacity of the isolated HDL will be assessed using the Matrigel tubulogenesis assay in vitro and correlated with HDL miRNA profiles. This project will provide the opportunity to learn a broad range of techniques including HDL isolation, tissue culture, RNA isolation and qPCR.

Projects available for: Honours/HDR

Location: SAHMRI

 

Research Project 2:

Title:  The use of high-density lipoproteins (HDL) as a novel theranostic miRNA delivery agent

Project description: There is growing evidence that targeted miRNA modulation is extremely feasible and may be more clinically effective in multifaceted diseases. Our preliminary findings suggest that miR-181c inhibition has significant promise to therapeutically reverse the impaired angiogenic response in diabetes. The biggest challenge in miRNA therapeutics is to safely and efficiently transport them to targeted cells and tissues. There is a switching focus for the use of HDL with the revelation of its emerging potential as a delivery agent. rHDL complexes composed of apolipoprotein (apo)A-I, the main protein component of HDL, and phospholipids can encapsulate drugs. Furthermore, HDL are known carriers of endogenous miRNAs, delivering them to recipient cells and imparting significant functional gene regulatory consequences. The use of HDL complexes to deliver miRNAs to prevent diabetic vascular complications has never been explored. This project will determine the efficacy of HDL-mediated delivery of miRNAs in endothelial cells in vitro and in and in vivo model of diabetic vascular complications. This project will provide the opportunity to learn a broad range of techniques including tissue culture, RT-PCR, Western blotting, HDL isolation and provide experience with an animal surgical model of angiogenesis.

Projects available for: Honours/HDR

Location: SAHMRI

Date Position Institution name
2017 - ongoing Affiliate Senior Lecturer The University of Adelaide
2017 - ongoing Senior Postdoctoral Researcher South Australian Health and Medical Research Institute
2012 - ongoing Conjoint Lecturer The University of Sydney

Language Competency
English Can read, write, speak, understand spoken and peer review
Malay Can read, write, speak and understand spoken

Date Institution name Country Title
The University of Sydney Australia PhD
Monash University Australia BSc (Biotechnology) (Hons)

Date Title Institution Country
2011 - 2016 Senior Research Officer The Heart Research Institute Australia
2007 - 2010 Research Officer The Heart Research Institute Australia

Year Citation
2025 Ruchka, P., Kushwaha, A., Marathe, J. A., Xiang, L., Chen, R., Kirk, R., . . . Li, J. (2025). 3D-printed micro-axicon enables extended depth-of-focus intravascular optical coherence tomography in vivo. Advanced Photonics, 7(2), 026003-1-026003-10.
DOI Scopus6 WoS7
2025 Primer, K. R., Tan, J. T. M., Sandeman, L., Nankivell, V. A., Stretton, L. G., Solly, E. L., . . . Bursill, C. A. (2025). Reconstituted High-Density Lipoproteins Rescue Diabetes-Impaired Endothelial Cell Metabolic Reprograming and Angiogenic Responses to Hypoxia.. Arterioscler Thromb Vasc Biol, 45(5), 683-701.
DOI Scopus1 WoS1 Europe PMC1
2025 Xiang, L., Chen, R., Tan, J. T. M., Nankivell, V., Bursill, C. A., McLaughlin, R. A., & Li, J. (2025). Identification and removal of system-induced autofluorescence in miniaturized fiber-optic fluorescence endoscopes. PNAS Nexus, 4(8), pgaf226-1-pgaf226-10.
DOI
2025 Nankivell, V. A., Sandeman, L., Stretton, L., Vidanapathirana, A. K., Rajora, M. A., Chen, J., . . . Bursill, C. A. (2025). Theranostic porphyrin nanoparticles identify atherosclerosis via multimodal imaging and elicit atheroprotective effects. Materials Today Bio, 34, 102202.
DOI Scopus1 WoS1 Europe PMC1
2025 Liu, J., Geremew, D., Sandeman, L. Y., Nankivell, V. A., Chen, R., Xiang, L., . . . Bursill, C. A. (2025). Development of a Novel Murine Model of In-Stent Neoatherosclerosis. Journal of the American Heart Association, 14(22), e041260.
DOI WoS1 Europe PMC1
2024 Lotfollahi, Z., Tan, J. T. M., Nankivell, V. A., Sandeman, L., Liyanage, S., Solly, E. L., . . . Bursill, C. A. (2024). Topical Reconstituted High-Density Lipoproteins Elicit Anti-Inflammatory Effects in Diabetic Wounds. Adv Wound Care (New Rochelle), 1-16.
DOI
2024 Williamson, A. E., Liyanage, S., Hassanshahi, M., Dona, M. S. I., Toledo-Flores, D., Tran, D. X. A., . . . Psaltis, P. J. (2024). Discovery of an embryonically derived bipotent population of endothelial-macrophage progenitor cells in postnatal aorta. Nature Communications, 15(1), 7097-1-7097-21.
DOI Scopus6 WoS6 Europe PMC6
2024 Tan, J. T. M., Cheney, C. V., Bamhare, N. E. S., Hossin, T., Bilu, C., Sandeman, L., . . . Bursill, C. A. (2024). Female Psammomys obesus Are Protected from Circadian Disruption-Induced Glucose Intolerance, Cardiac Fibrosis and Adipocyte Dysfunction. International Journal of Molecular Sciences, 25(13), 7265-1-7265-19.
DOI Scopus4 WoS4 Europe PMC4
2024 Tan, J. T. M., Price, K. J., Fanshaw, S. -R., Bilu, C., Pham, Q. T., Pham, A., . . . Bursill, C. A. (2024). Exercise Reduces Glucose Intolerance, Cardiac Inflammation and Adipose Tissue Dysfunction in Psammomys obesus Exposed to Short Photoperiod and High Energy Diet. International Journal of Molecular Sciences, 25(14), 7756-1-7756-13.
DOI Scopus4 WoS3 Europe PMC3
2024 Chen, R., Sandeman, L., Nankivell, V., Tan, J. T. M., Rashidi, M., Psaltis, P. J., . . . Li, J. (2024). Detection of atherosclerotic plaques with HDL-like porphyrin nanoparticles using an intravascular dual-modality optical coherence tomography and fluorescence system. Scientific Reports, 14(1), 12359-1-12359-10.
DOI Scopus8 WoS5 Europe PMC3
2024 Gu, J., Sun, Y., Cheng, W., Guo, K., Chen, Y., Zhang, S., & Chong, Z. (2024). Hard-soft biomimetic structure distribution enhanced wear resistance of AISI1045 steel by laser processing. MATERIALS LETTERS, 357, 5 pages.
DOI WoS1
2024 Nankivell, V., Vidanapathirana, A. K., Hoogendoorn, A., Tan, J. T. M., Verjans, J., Psaltis, P. J., . . . Bursill, C. A. (2024). Targeting macrophages with multifunctional nanoparticles to detect and prevent atherosclerotic cardiovascular disease. Cardiovascular Research, 120(8), 819-838.
DOI Scopus22 WoS19 Europe PMC18
2024 Wong, N. K. P., Solly, E. L., Le, R., Nankivell, V. A., Mulangala, J., Psaltis, P. J., . . . Tan, J. T. M. (2024). TRIM2 Selectively Regulates Inflammation-Driven Pathological Angiogenesis without Affecting Physiological Hypoxia-Mediated Angiogenesis. International Journal of Molecular Sciences, 25(6), 3343.
DOI Scopus1 WoS1 Europe PMC1
2023 Santovito, D., Fan, Y., Elia, L., Tan, J. T. M., & van der Vorst, E. P. C. (2023). Editorial: Emerging roles of miRNAs in cardiovascular disease. Frontiers in Cardiovascular Medicine, 10, 3 pages.
DOI Scopus1 Europe PMC1
2023 Schwarz, N., Fernando, S., Chen, Y. -C., Salagaras, T., Rao, S. R., Liyanage, S., . . . Psaltis, P. J. (2023). Colchicine exerts anti-atherosclerotic and -plaque-stabilizing effects targeting foam cell formation. The FASEB Journal, 37(4), 1-20.
DOI Scopus54 WoS53 Europe PMC44
2022 Fernando, S., Salagaras, T., Schwarz, N., Sandeman, L., Tan, J. T. M., Xie, J., . . . Psaltis, P. J. (2022). Eukaryotic elongation factor 2 kinase regulates foam cell formation via translation of CD36. The FASEB Journal, 36(2), 1-19.
DOI Scopus4 WoS5 Europe PMC3
2022 Mulangala, J., Akers, E. J., Solly, E. L., Bamhare, P. M., Wilsdon, L. A., Wong, N. K. P., . . . Di Bartolo, B. A. (2022). Pro-Calcific Environment Impairs Ischaemia-Driven Angiogenesis.. International journal of molecular sciences, 23(6), 1-21.
DOI Scopus1 WoS1 Europe PMC1
2022 Shin, J., Zhou, X., Tan, J. T. M., Hyppönen, E., Benyamin, B., & Lee, S. H. (2022). Lifestyle Modifies the Diabetes-Related Metabolic Risk, Conditional on Individual Genetic Differences. Frontiers in Genetics, 13, 759309-1-759309-10.
DOI Scopus7 WoS7 Europe PMC8
2022 Thomas, E., Chapman, N., de Camargo Catapan, S., Climie, R., Wise, S., Mirabito Colafella, K., . . . Marques, F. (2022). Strategies to support early- and mid-career cardiovascular researchers to thrive.
DOI
2022 Chapman, N., Thomas, E. E., Tan, J. T. M., Inglis, S. C., Wu, J. H. Y., Climie, R. E., . . . Marques, F. Z. (2022). A roadmap of strategies to support cardiovascular researchers: from policy to practice. Nature reviews. Cardiology, 19(11), 765-777.
DOI Scopus12 WoS11 Europe PMC8
2022 Shearston, K., Tan, J. T. M., Cochran, B. J., & Rye, K. A. (2022). Inhibition of Vascular Inflammation by Apolipoprotein A-IV. Frontiers in Cardiovascular Medicine, 9, 14 pages.
DOI Scopus17 WoS15 Europe PMC15
2021 Williamson, A., Liyanage, S., Hassanshahi, M., Dona, M., Toledo-Flores, D., Tran, D. X. A., . . . Psaltis, P. (2021). Discovery of embryonically derived bipotent endothelial-macrophage progenitor cells in postnatal aorta.
DOI
2021 Ravindran, D., Galougahi, K. K., Tan, J. T. M., Kavurma, M. M., & Bursill, C. A. (2021). The Multiple Roles of Chemokines in the Mechanisms of Stent Biocompatibility.. Cardiovasc Res, 117(11), 2299-2308.
DOI Scopus6 Europe PMC5
2021 Morrison, K. R., Solly, E. L., Shemesh, T., Psaltis, P. J., Nicholls, S. J., Brown, A., . . . Tan, J. T. M. (2021). Elevated HDL-bound miR-181c-5p level is associated with diabetic vascular complications in Australian Aboriginal people. Diabetologia, 64(6), 1402-1411.
DOI Scopus18 WoS19 Europe PMC18
2021 Pisaniello, A. D., Psaltis, P. J., King, P. M., Liu, G., Gibson, R. A., Tan, J. T. M., . . . Di Bartolo, B. A. (2021). Omega-3 fatty acids ameliorate vascular inflammation: a rationale for their atheroprotective effects. Atherosclerosis, 324, 27-37.
DOI Scopus38 WoS36 Europe PMC32
2021 Nankivell, V. A., Tan, J. T. M., Wilsdon, L. A., Morrison, K. R., Bilu, C., Psaltis, P. J., . . . Brown, A. (2021). Circadian disruption by short light exposure and a high energy diet impairs glucose tolerance and increases cardiac fibrosis in Psammomys obesus. Scientific reports, 11(1), 1-13.
DOI Scopus14 WoS14 Europe PMC12
2021 Solly, E. L., Psaltis, P. J., Bursill, C. A., & Tan, J. T. M. (2021). The Role of miR-181c in Mechanisms of Diabetes-Impaired Angiogenesis: An Emerging Therapeutic Target for Diabetic Vascular Complications. Frontiers in Pharmacology, 12, 718679-1-718679-16.
DOI Scopus19 WoS18 Europe PMC15
2020 Climie, R. E., Wu, J. H. Y., Calkin, A. C., Chapman, N., Inglis, S. C., Mirabito Colafella, K. M., . . . Australian Cardiovascular Alliance. (2020). Lack of strategic funding and long-term job security threaten to have profound effects on cardiovascular researcher retention in Australia. Heart, Lung and Circulation, 29(11), 1588-1595.
DOI Scopus13 WoS11 Europe PMC12
2020 Primer, K. R., Psaltis, P. J., Tan, J. T. M., & Bursill, C. A. (2020). The Role of High-Density Lipoproteins in Endothelial Cell Metabolism and Diabetes-Impaired Angiogenesis.. Int J Mol Sci, 21(10), 1-21.
DOI Scopus30 WoS27 Europe PMC27
2020 Shin, J., Zhou, X., Tan, J., Hyppönen, E., Benyamin, B., & Lee, H. (2020). Lifestyle modifies the diabetes-related metabolic risk, conditional on individual genetic differences.
DOI
2019 Yuan, J., Tan, J. T. M., Rajamani, K., Solly, E. L., King, E. J., Lecce, L., . . . Ng, M. K. C. (2019). Fenofibrate rescues diabetes-related impairment of ischemia-mediated angiogenesis by PPARα-independent modulation of thioredoxin-interacting protein. Diabetes, 68(5), 1040-1053.
DOI Scopus21 WoS21 Europe PMC20
2019 Tan, J. T. M., Nankivell, V. A., Bilu, C., Shemesh, T., Nicholls, S. J., Zimmet, P., . . . Bursill, C. A. (2019). High-Energy Diet and Shorter Light Exposure Drives Markers of Adipocyte Dysfunction in Visceral and Subcutaneous Adipose Depots of Psammomys obesus.. Int J Mol Sci, 20(24), 17 pages.
DOI Scopus14 WoS14 Europe PMC12
2019 Solly, E. L., Dimasi, C. G., Bursill, C. A., Psaltis, P. J., & Tan, J. T. M. (2019). MicroRNAs as therapeutic targets and clinical biomarkers in atherosclerosis. Journal of Clinical Medicine, 8(12), 2199-1-2199-26.
DOI Scopus53 WoS51 Europe PMC43
2019 MacEr-Wright, J. L., Stanley, N. R., Portman, N., Tan, J. T., Bursill, C., Rayner, B. S., & Hawkins, C. L. (2019). A role for chlorinated nucleosides in the perturbation of macrophage function and promotion of inflammation. Chemical Research in Toxicology, 32(6), 1223-1234.
DOI Scopus16 WoS11 Europe PMC11
2019 Nguyen, M. T., Fernando, S., Schwarz, N., Tan, J. T. M., Bursill, C. A., & Psaltis, P. J. (2019). Inflammation as a therapeutic target in atherosclerosis. Journal of Clinical Medicine, 8(8), 1109-1-1109-20.
DOI Scopus149 WoS136 Europe PMC108
2018 Ridiandries, A., Tan, J. T. M., & Bursill, C. A. (2018). The role of chemokines in wound healing. International Journal of Molecular Sciences, 19(10), 20 pages.
DOI Scopus380 WoS346 Europe PMC301
2018 Cannizzo, C. M., Adonopulos, A. A., Solly, E. L., Ridiandries, A., Vanags, L. Z., Mulangala, J., . . . Tan, J. T. (2018). VEGFR2 is activated by high-density lipoproteins and plays a key role in the proangiogenic action of HDL in ischemia. FASEB Journal, 32(6), 2911-2922.
DOI Scopus11 WoS11 Europe PMC10
2018 Vanags, L. Z., Tan, J. T. M., Galougahi, K. K., Schaefer, A., Wise, S. G., Murphy, A., . . . Bursill, C. A. (2018). Apolipoprotein A-I Reduces In-Stent Restenosis and Platelet Activation and Alters Neointimal Cellular Phenotype. JACC: Basic to Translational Science, 3(2), 200-209.
DOI Scopus20 WoS18 Europe PMC16
2018 Morton, J., Bao, S., Vanags, L., Tsatralis, T., Ridiandries, A., Siu, C., . . . Bursill, C. (2018). Strikingly different atheroprotective effects of apolipoprotein A-I in early- versus late-stage atherosclerosis. JACC: Basic to Translational Science, 3(2), 187-199.
DOI Scopus18 WoS17 Europe PMC15
2018 Wong, N., Nicholls, S., Tan, J., & Bursill, C. (2018). The role of high-density lipoproteins in diabetes and its vascular complications. International Journal of Molecular Sciences, 19(6), 21 pages.
DOI Scopus61 WoS47 Europe PMC48
2018 Wong, N. K. P., Cheung, H., Solly, E. L., Vanags, L. Z., Ritchie, W., Nicholls, S. J., . . . Tan, J. T. M. (2018). Exploring the roles of CREBRF and TRIM2 in the regulation of angiogenesis by high-density lipoproteins. International Journal of Molecular Sciences, 19(7), 1903-1-1903-17.
DOI Scopus16 WoS16 Europe PMC16
2018 Hourigan, S. T., Solly, E. L., Nankivell, V. A., Ridiandries, A., Weimann, B., Henriquez, R., . . . Tan, J. T. M. (2018). The regulation of miRNAs by reconstituted high-density lipoproteins in diabetes-impaired angiogenesis. Scientific Reports, 8(1), 13596.
DOI Scopus26 WoS25 Europe PMC21
2017 Vanags, L. Z., Tan, J. T. M., Santos, M., Michael, P. S., Ali, Z., Bilek, M. M. M., . . . Bursill, C. A. (2017). Plasma activated coating immobilizes apolipoprotein A-I to stainless steel surfaces in its bioactive form and enhances biocompatibility. Nanomedicine: Nanotechnology, Biology, and Medicine, 13(7), 2141-2150.
DOI Scopus10 WoS9 Europe PMC6
2017 McRobb, L. S., McGrath, K. C. Y., Tsatralis, T., Liong, E. C., Tan, J. T. M., Hughes, G., . . . Heather, A. K. (2017). Estrogen Receptor Control of Atherosclerotic Calcification and Smooth Muscle Cell Osteogenic Differentiation. Arteriosclerosis Thrombosis and Vascular Biology, 37(6), 1127-1137.
DOI Scopus55 WoS53 Europe PMC46
2017 Ridiandries, A., Bursill, C., & Tan, J. (2017). Broad-spectrum inhibition of the CC-chemokine class improves wound healing and wound angiogenesis. International Journal of Molecular Sciences, 18(1), 155-1-155-15.
DOI Scopus36 WoS27 Europe PMC25
2017 Ridiandries, A., Tan, J., Ravindran, D., Williams, H., Medbury, H., Lindsay, L., . . . Bursill, C. (2017). CC-chemokine class inhibition attenuates pathological angiogenesis while preserving physiological angiogenesis. FASEB Journal, 31(3), 1179-1192.
DOI Scopus14 WoS13 Europe PMC14
2017 Tan, J. T. M., Prosser, H. C. G., Dunn, L. L., Vanags, L. Z., Ridiandries, A., Tsatralis, T., . . . Bursill, C. A. (2017). High-Density Lipoproteins Rescue Diabetes-Impaired Angiogenesis via Scavenger Receptor Class B Type I (vol 65, pg 3091, 2016). DIABETES, 66(4), 1 page.
DOI Europe PMC1
2017 Ravindran, D., Ridiandries, A., Vanags, L., Henriquez, R., Cartland, S., Tan, J., & Bursill, C. (2017). Chemokine binding protein 'M3' limits atherosclerosis in apolipoprotein E-/- mice. PLoS ONE, 12(3), e0173224-1-e0173224-23.
DOI Scopus20 WoS20 Europe PMC18
2016 Lam, Y., Lecce, L., Tan, J., Bursill, C., Handelsman, D., & Ng, M. (2016). Androgen receptor-mediated genomic androgen action augments ischemia-induced neovascularization. Endocrinology, 157(12), 4853-4864.
DOI Scopus8 WoS7 Europe PMC6
2016 Tsatralis, T., Ridiandries, A., Robertson, S., Vanags, L., Lam, Y., Tan, J. T., . . . Bursill, C. (2016). Reconstituted high-density lipoproteins promote wound repair and blood flow recovery in response to ischemia in aged mice. Lipids in Health and Disease, 15(1), 150-1-150-12.
DOI Scopus20 WoS17 Europe PMC19
2016 Ridiandries, A., Tan, J., & Bursill, C. (2016). The role of CC-chemokines in the regulation of angiogenesis. International Journal of Molecular Sciences, 17(11), 1856-1-1856-16.
DOI Scopus94 WoS87 Europe PMC77
2016 Tan, J., Prosser, H., Dunn, L., Vanags, L., Ridiandries, A., Tsatralis, T., . . . Bursill, C. (2016). High-density lipoproteins rescue diabetes-impaired angiogenesis via scavenger receptor Class B Type I. Diabetes, 65(10), 3091-3103.
DOI Scopus42 WoS41 Europe PMC36
2016 Arnott, C., Punnia-Moorthy, G., Tan, J., Sadeghipour, S., Bursill, C., & Patel, S. (2016). The Vascular Endothelial Growth Factor Inhibitors Ranibizumab and Aflibercept Markedly Increase Expression of Atherosclerosis-Associated Inflammatory Mediators on Vascular Endothelial Cells. PLOS ONE, 11(3), e0150688.
DOI Scopus22 WoS24 Europe PMC19
2015 Tan, J., Ng, M., & Bursill, C. (2015). The role of high-density lipoproteins in the regulation of angiogenesis. Cardiovascular Research, 106(2), 184-193.
DOI Scopus44 WoS40 Europe PMC37
2014 Prosser, H., Tan, J., Dunn, L., Patel, S., Vanags, L., Bao, S., . . . Bursill, C. (2014). Multifunctional regulation of angiogenesis by high-density lipoproteins. Cardiovascular Research, 101(1), 145-154.
DOI Scopus44 WoS41 Europe PMC36
2014 Tan, J., Hamish, H., Vanags, L., Monger, S., Ng, M., & Bursill, C. (2014). High-density lipoproteins augment hypoxia-induced angiogenesis via regulation of post-translational modulation of hypoxia-inducible factor 1α. FASEB Journal, 28(1), 206-217.
DOI Scopus57 WoS52 Europe PMC52
2014 McGrath, K. C., Li, X. H., Whitworth, P. T., Kasz, R., Tan, J. T., McLennan, S. V., . . . Heather, A. K. (2014). High density lipoproteins improve insulin sensitivity in high-fat diet-fed mice by suppressing hepatic inflammation. Journal of Lipid Research, 55(3), 421-430.
DOI Scopus39 WoS40 Europe PMC36
2013 Tan, J. T. M., McLennan, S. V., Williams, P. F., Rezaeizadeh, A., Lo, L. W. Y., Bonner, J. G., & Twigg, S. M. (2013). Connective tissue growth factor/CCN-2 is upregulated in epididymal and subcutaneous fat depots in a dietary-induced obesity model.. American Journal of Physiology Endocrinology and Metabolism, 304(12), E1291-E1302.
DOI Scopus23 WoS21 Europe PMC22
2013 Dunn, L., Prosser, H., Tan, J., Vanags, L., Ng, M., & Bursill, C. (2013). Murine model of wound healing. Journal of visualized experiments : JoVE, (75), e50265.
DOI Scopus44
2013 Dunn, L., Prosser, H., Tan, J., Vanags, L., Ng, M., & Bursill, C. (2013). Murine model of wound healing. Journal of Visualized Experiments, 2013(75), 1-6.
DOI Scopus227 WoS218 Europe PMC129
2011 Di Bartolo, B., Vanags, L., Tan, J., Bao, S., Rye, K., Barter, P., & Bursill, C. (2011). The apolipoprotein A-I mimetic peptide, ETC-642, reduces chronic vascular inflammation in the rabbit.. Lipids in health and disease, 10(1), 224.
DOI Scopus30 WoS28 Europe PMC20
2011 Moheimani, F., Tan, J. T. M., Brown, B. E., Heather, A. K., Van Reyk, D. M., & Davies, M. J. (2011). Effect of exposure of human monocyte-derived macrophages to high, versus normal, glucose on subsequent lipid accumulation from glycated and acetylated low-density lipoproteins. Experimental Diabetes Research, 2011, 10 pages.
DOI Scopus11 WoS12 Europe PMC9
2010 Lane, A. E., Tan, J. T. M., Hawkins, C. L., Heather, A. K., & Davies, M. J. (2010). The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages. Biochemical Journal, 430(1), 161-169.
DOI Scopus79 WoS75 Europe PMC64
2010 Soosai, J., Ward, L., & Ziaian, T. (2010). Experiences of Chinese immigrants and Anglo-Australians ageing in Australia: A cross-cultural perspective on successful ageing. Journal of Health Psychology, 15(5 Sp Iss), 697-706.
DOI Scopus33 WoS27 Europe PMC16
2009 McGrath, K. C. Y., Li, X. H., Puranik, R., Liong, E. C., Tan, J. T. M., Dy, V. M., . . . Heather, A. K. (2009). Role of 3β-hydroxysteroid-Δ24 reductase in mediating antiinflammatory effects of high-density lipoproteins in endothelial cells. Arteriosclerosis Thrombosis and Vascular Biology, 29(6), 877-882.
DOI Scopus85 WoS82 Europe PMC72
2008 Tan, J. T. M., McLennan, S. V., Song, W. W., Lo, L. W. Y., Bonner, J. G., Williams, P. F., & Twigg, S. M. (2008). Connective tissue growth factor inhibits adipocyte differentiation. American Journal of Physiology Cell Physiology, 295(3), C740-C751.
DOI Scopus85 WoS79 Europe PMC73
2007 Lim, C. K., Tan, J. T. M., Ravichandran, A., Chan, Y. C., & Ton, S. H. (2007). Comparison of PCR-based genotyping methods for hepatitis B virus.. The Malaysian journal of pathology, 29(2), 79-90.
Europe PMC3
2006 Chee, K. L., Tan, J. T. M., Khoo, J. B. S., Ravichandran, A., Hsin, M. L., Yin, C. C., & So, H. T. (2006). Correlations of HBV genotypes, mutations affecting HBeAg expression and HBeAg/anti-HBe status in HBV carriers. International Journal of Medical Sciences, 3(1), 14-20.
DOI Scopus23 Europe PMC17

Year Citation
2020 Wong, N. K. P., Solly, E. L., Bursill, C. A., Tan, J. T. M., & Ng, M. K. C. (2020). Pathophysiology of Angiogenesis and Its Role in Vascular Disease. In N. K. P. Wong (Ed.), Mechanisms of Vascular Disease (pp. 89-116). Springer International Publishing.
DOI Scopus8

Year Citation
2024 Solly, E. L., Bouman Chen, Z., Luo, Y., Mulangala, J., Di Bartolo, B. A., Nicholls, S. J., . . . Tan, J. T. M. (2024). Inhibition of microRNA-181c-5p rescues diabetes-impaired angiogenesis through activation of key mediators of angiogenesis, cell survival and novel genes, elmo3 and trib1. In EUROPEAN HEART JOURNAL Vol. 45 (pp. 1 page). ENGLAND, London: OXFORD UNIV PRESS.
DOI WoS1
2024 Bursill, C., Pullen, B. J., Debebe, D., Sandeman, L., Wattchow, N. E., Vidanapathirana, A., . . . Packer, N. H. (2024). Deletion of the asialyloglycoprotein receptor-1 (ASGR1) causes atheroprotective effects in vitro and in vivo. In Abstracts of the European Society of Cardiology Congress (ESC, 2024) as published in European Heart Journal Vol. 45 (pp. ehae6663875-1). London, England and Virtual Online: Oxford University Press.
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2022 Solly, E. L., Mulangala, J., Di Bartolo, B. A., Nicholls, S. J., Psaltis, P. J., Bursill, C. A., & Tan, J. T. M. (2022). Inhibition of microRNA-181c rescues diabetes-impaired angiogenesis through activation of key angiogenesis mediators. In DIABETOLOGIA Vol. 65 (pp. S25-S26). Stockholm, SWEDEN: SPRINGER.
2020 Cannizzo, C., Solly, E., Olaya, L. F., Abdollahi, M., Sutanto, S. S., Twigg, S. M., . . . Mclennan, S. (2020). Inhibition of miRNA-200b Rescues Diabetes-Impaired Angiogenesis. In DIABETES Vol. 69 (pp. 2 pages). ELECTR NETWORK: AMER DIABETES ASSOC.
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2019 Bursill, C., Primer, K. R., Solly, E., Psaltis, P. J., & Tan, J. T. M. (2019). High-density lipoproteins rescue diabetes-impaired angiogenesis by restoring cellular metabolic reprogramming responses to hypoxia. In EUROPEAN HEART JOURNAL Vol. 40 (pp. 337). FRANCE, Paris: OXFORD UNIV PRESS.
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2019 Morrison, K. R., Bursill, C., Solly, E., Shemesh, T., Nicholls, S., Brown, A. D., & Tan, J. T. M. (2019). HDL miR-181c as a Novel Biomarker for Diabetic Vascular Complications in Australian Aboriginal People. In DIABETES Vol. 68 (pp. 2 pages). San Francisco, CA: AMER DIABETES ASSOC.
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2019 Pisaniello, A. D., King, P., Di Bartolo, B. A., Liu, G., Gibson, R. A., Tan, J. T. M., . . . Nicholls, S. (2019). IMPACT OF FISH OIL SUPPLEMENTATION ON ACUTE VASCULAR INFLAMMATION IN HEALTHY VOLUNTEERS. In JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY Vol. 73 (pp. 2091). New Orleans, LA: ELSEVIER SCIENCE INC.
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2019 Mulangala, J., Akers, E., Solly, E. L., Bamhare, P. M., Wilsdon, L. A., Tan, J. T., . . . DiBartolo, B. A. (2019). Elevated Calcium Drives Ischemia-Induced Angiogenesis. In CIRCULATION Vol. 140 (pp. 2 pages). Philadelphia, PA: LIPPINCOTT WILLIAMS & WILKINS.
2018 Mulangala, J., Akers, E. J., Solly, E. L., Psaltis, P. J., Tan, J. T., Nicholls, S. J., . . . Di Bartolo, B. A. (2018). Elevated Calcium Drives Inflammatory-Driven Angiogenesis. In ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY Vol. 38 (pp. 2 pages). San Francisco, CA: LIPPINCOTT WILLIAMS & WILKINS.
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2017 Cannizzo, C. M., Adonopulos, A. A., Ridiandries, A., Vanags, L. Z., Yuen, S. C. G., Tsatralis, T., . . . Tan, J. T. (2017). VEGFR2 is Activated by High-Density Lipoproteins and Plays a Key Role in the Pro-Angiogenic Action of HDL in Ischemia. In CIRCULATION Vol. 136 (pp. 1 page). Anaheim, CA: LIPPINCOTT WILLIAMS & WILKINS.
2017 Hourigan, S. T., Ridiandries, A., Tepper, E. R., Zhang, J. Q., Henriquez, R., Tsatralis, T., . . . Tan, J. T. (2017). The Regulation of miRNAs in rHDL-Induced Rescue of Diabetes-Impaired Angiogenesis. In CIRCULATION Vol. 136 (pp. 1 page). Anaheim, CA: LIPPINCOTT WILLIAMS & WILKINS.
2014 Vanags, L., Tan, J., Wise, S., Ali, Z., & Bursill, C. (2014). ApoA-I Suppresses Neointimal Hyperplasia Following Stent Deployment and Modulates Neointimal Cellular Phenotype. In CIRCULATION Vol. 130 (pp. 2 pages). LIPPINCOTT WILLIAMS & WILKINS.
2014 Vanags, L. Z., Tan, J., Michael, J., Bilek, M., Wise, S., & Bursill, C. (2014). Immobilised apoA-I and High-Density Lipoproteins are Anti-Thrombotic and Exert Anti-Inflammatory Effects in Vascular Smooth Muscle Cells. In CIRCULATION Vol. 130 (pp. 2 pages). Chicago, IL: LIPPINCOTT WILLIAMS & WILKINS.
2014 Macer-Wright, J., Stanley, N., Tan, J., Bursill, C., & Hawkins, C. (2014). Chlorinated Nucleosides - Novel Mediators or Biomarkers of Disease?. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 76 (pp. S45-S46). ELSEVIER SCIENCE INC.
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2014 Vanags, L., Tan, J., Michael, J., Bilek, M., Wise, S., & Bursill, C. (2014). STAINLESS STEEL-BOUND APOA-I AND RECONSTITUTED HIGH-DENSITY LIPOPROTEINS ARE ANTI-THROMBOTIC AND CAUSE ANTI-INFLAMMATORY EFFECTS IN HUMAN VASCULAR SMOOTH MUSCLE CELLS. In HYPERTENSION Vol. 63 (pp. E172-E173). Melbourne, AUSTRALIA: LIPPINCOTT WILLIAMS & WILKINS.
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2013 Macer-Wright, J., Stanley, N., Tan, J., Bursill, C., & Hawkins, C. (2013). Role of Chlorinated Nucleosides Produced by Hypochlorous Acid in the Perturbation of Cellular Function under Inflammatory Conditions. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 65 (pp. S143). ELSEVIER SCIENCE INC.
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2010 Lane, A. E., Tan, J. T. M., Hawkins, C. L., Heather, A. K., & Davies, M. J. (2010). The Myeloperoxidase-derived Oxidant HOSCN Inhibits Protein Tyrosine Phosphatases and Modulates Cell Signalling via the Mitogen-activated Protein Kinase (MAPK) Pathway in Macrophages. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 49 (pp. S129). Orlando, FL: ELSEVIER SCIENCE INC.
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2010 Tan, J. T., Gorantla, S., Mohan, S., Jardine, D., Ahmed, L., & Park, C. M. (2010). Vitamin D Status and Supplementation in Bariatric Surgery Patients in an Inner City Hospital.. In ENDOCRINE REVIEWS Vol. 31 (pp. 1 page). CA, San Diego: ENDOCRINE SOC.
2009 Lane, A. E., Tan, J., Hawkins, C. L., Heather, A. K., & Davies, M. J. (2009). The Myeloperoxidase-Derived Oxidant HOSCN Inhibits Protein Tyrosine Phosphatases and Modulates Cell Signalling via the MAPK Pathway in Macrophages. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 47 (pp. S42-S43). San Francisco, CA: ELSEVIER SCIENCE INC.
2009 Heather, A. K., Li, X. -H., Bartusch, M., Dy, V., Liong, E. C., McGrath, K. C., & Tan, J. T. (2009). DHCR24 Is a Negative Regulator of Nuclear Factor-κB and Chronic Inflammation in Human Endothelial Cells. In ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY Vol. 29 (pp. E27-E28). Washington, DC: LIPPINCOTT WILLIAMS & WILKINS.
2009 Tan, J., Li, X. -H., Bartusch, M., Dy, V., Liong, E., McGrath, K., . . . Heather, A. (2009). LOW DHCR24 LEVELS ARE ASSOCIATED WITH CHRONIC INFLAMMATION AND APOPTOSIS IN HUMAN ENDOTHELIAL CELLS. In ATHEROSCLEROSIS SUPPLEMENTS Vol. 10 (pp. 1 page). ELSEVIER IRELAND LTD.
2009 McRobb, L., Liong, E., Tan, J., & Heather, A. (2009). THE ROLE OF ESTROGEN RECEPTORS ALPHA AND BETA IN ATHEROSCLEROTIC LESION CALCIFICATION IN APOLIPOPROTEIN E-NULL MICE. In ATHEROSCLEROSIS SUPPLEMENTS Vol. 10 (pp. 1 page). ELSEVIER IRELAND LTD.
2009 Liong, E., McGrath, K., Tan, J., Li, X. -H., Dy, V., Barter, P., . . . Heather, A. (2009). ROLE OF 3B-HYDROXYSTEROID-[DELTA]24 REDUCTASE IN MEDIATING THE ANTI-INFLAMMATORY EFFECTS OF HIGH-DENSITY LIPOPROTEINS IN ENDOTHELIAL CELLS. In ATHEROSCLEROSIS SUPPLEMENTS Vol. 10 (pp. 1 page). ELSEVIER IRELAND LTD.
2008 Akeefe, H., Maltais, J. -A. B., Murphy, A., Chin-Dusting, J., Sviridov, D., Heather, A., . . . Brewer, H. B. (2008). An Apo A-I mimetic peptide LSI-518P exhibits ABCA1-specific efflux and anti-inflammatory properties. In ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY Vol. 28 (pp. E92). Atlanta, GA: LIPPINCOTT WILLIAMS & WILKINS.
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2004 Kaech, S. M., Tan, J. T., Wherry, E. J., Konieczny, B. T., Surh, C. D., & Ahmed, R. (2004). Selective expression of the IL-7R identifies effector CD8 T cells that give rise to long-lived memory cells. In FASEB JOURNAL Vol. 18 (pp. A798). DC, Washington: FEDERATION AMER SOC EXP BIOL.
2002 Bondi-Boyd, B., Leroy, E., Kieper, W. C., Tan, J. T., & Surh, C. D. (2002). Age-associated changes in the factors regulating homeostasis of mature T cells. In FASEB JOURNAL Vol. 16 (pp. A345). FEDERATION AMER SOC EXP BIOL.

Year Citation
2024 Nankivell, V., Sandeman, L., Stretton, L., Vidanapathirana, A. K., Rajora, M. A., Chen, J., . . . Bursill, C. A. (2024). Biomimetic porphyrin-lipid nanoparticles - novel nanoscale theranostics for multimodal imaging and therapy in atherosclerotic cardiovascular disease. Poster session presented at the meeting of Abstracts of the European Society of Cardiologists ESC Congress 2024, as published in European Heart Journal. London, UK: Oxford University Press.
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2022 Nankivell, V. A., Vidanapathirana, A., Rajora, M., Psaltis, P., Tan, J. T., Tieu, W., . . . Bursill, C. A. (2022). Theranostic Properties of Porphysome Nanoparticles in Atherosclerotic Cardiovascular Disease. Poster session presented at the meeting of CIRCULATION. IL, Chicago: LIPPINCOTT WILLIAMS & WILKINS.
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2022 Primer, K. R., Tan, J. T., Psaltis, P. J., & Bursill, C. A. (2022). Pyruvate Dehydrogenase Kinase 4 is a Novel Regulator of Endothelial Cell Mitochondrial Respiration in Diabetes-Impaired Angiogenesis: Implications for Preventing Diabetic Vascular Complications. Poster session presented at the meeting of CIRCULATION. IL, Chicago: LIPPINCOTT WILLIAMS & WILKINS.
2022 Lotfollahi, Z., Tan, J. T., Dawson, J., Fitridge, R., & Bursill, C. A. (2022). Tracking High-Density Lipoprotein Functionality in Diabetic and Non-Diabetic Patients With Toe Amputations. Poster session presented at the meeting of CIRCULATION. IL, Chicago: LIPPINCOTT WILLIAMS & WILKINS.
2022 Pullen, B. J., Vidanapathirana, A. K., Sandeman, L., Everest-Dass, A., Kolarich, D., Tan, J. T., . . . Bursill, C. A. (2022). Deletion of the Asialyloglycoprotein Receptor-1 Causes Athero-Protective Effects in vitro and in vivo. Poster session presented at the meeting of CIRCULATION. IL, Chicago: LIPPINCOTT WILLIAMS & WILKINS.
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2020 Pisaniello, A. D., Di Bartolo, B. A., Liu, G., King, P. M., Gibson, R. A., Tan, J. T. M., & Nicholls, S. J. (2020). EICOSAPENTAENOIC ACID AMELIORATES VASCULAR INFLAMMATION: A MECHANISTIC RATIONALE FOR ITS ATHEROPROTECTIVE EFFECTS. Poster session presented at the meeting of JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. Chicago, IL: ELSEVIER SCIENCE INC.
2019 Williamson, A., Toledo, D. F., Schwarz, N., Fernando, S., Dimasi, C., Liyanage, S., . . . Psaltis, P. J. (2019). Postnatal mouse aorta contains yolk sac-derived haemangioblasts with myeloid and endothelial plasticity and vasculogenic capacity. Poster session presented at the meeting of European Heart Journal. Paris, France: Oxford University Press.
2019 Solly, E., Hourigan, S. T., Mulangala, J., Psaltis, P. J., Di Bartolo, B., Martin, N., . . . Tan, J. T. M. (2019). Inhibition of miR-181c Rescues Diabetes-Impaired Angiogenesis. Poster session presented at the meeting of DIABETES. San Francisco, CA: AMER DIABETES ASSOC.
DOI
2019 Fernando, S., Schwarz, N., Sandeman, L., Skoumbourdis, T., Zareh, J., Williamson, A., . . . Psaltis, P. J. (2019). Eukaryotic Elongation Factor 2 Kinase Regulates Cholesterol Uptake by Macrophages via Cd36 Scavenger Receptor Expression. Poster session presented at the meeting of CIRCULATION. Philadelphia, PA: LIPPINCOTT WILLIAMS & WILKINS.
2019 Wong, N. K., Solly, E., Nicholls, S., Psaltis, P., Ng, M. K., Bursill, C. A., & Tan, J. T. (2019). <i>TRIM2</i> an<i>d CREBRF</i> Are Novel Regulators of Angiogenic Functions in Human Coronary Artery Endothelial Cells. Poster session presented at the meeting of CIRCULATION. Philadelphia, PA: LIPPINCOTT WILLIAMS & WILKINS.
2017 Morton, J., Bao, S., Vanags, L., Tsatralis, T., Ridiandries, A., Siu, C. -W., . . . Bursill, C. (2017). Stage-specific Effects of Apolipoprotein (apo) A-I Raising in Atherosclerosis: ApoA-I Suppresses Plaque Size and Preserves High-density Lipoprotein Function in Apo E<SUP>-/-</SUP> Mice With Early Stage <i>But Not</i> Late-stage Disease. Poster session presented at the meeting of CIRCULATION. Anaheim, CA: LIPPINCOTT WILLIAMS & WILKINS.
2016 Tan, J. T., Hourigan, S. T., Zhang, J. Q., Wong, N. K., Tepper, E. R., Prosser, H. C., . . . Bursill, C. A. (2016). miRNA-181c and its putative target TRIM2 mediate the ability of high density lipoproteins to rescue diabetes-impaired angiogenesis. Poster session presented at the meeting of as published in Diabetes. New Orleans, LA: American Diabetes Association.
2015 Tan, J. T. M., Prosser, H. C. G., Dunn, L. L., Vanags, L. Z., Ridiandries, A., Tsatralis, T., . . . Bursill, C. A. (2015). High Density Lipoproteins Rescue Diabetes-Impaired Angiogenesis via Scavenger Receptor-BI and Restoration of VEGF and HIF-1 alpha Stability. Poster session presented at the meeting of DIABETES. Boston, MA: AMER DIABETES ASSOC.
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2013 Prosser, H. C., Tan, J. T., Dunn, L. L., Patel, S., Vanags, L. Z., Monger, S., . . . Bursill, C. A. (2013). Multifunctional Regulation of Angiogenesis by High Density Lipoproteins. Poster session presented at the meeting of CIRCULATION. Dallas, TX: LIPPINCOTT WILLIAMS & WILKINS.

Year Citation
2025 Liu, J., Geremew, D., Sandeman, L. Y., Nankivell, V. A., Chen, R., Xiang, L., . . . Bursill, C. A. (2025). Development of a novel murine model of in-stent neoatherosclerosis.
DOI
2024 Wong, N. K. P., Solly, E., Le, R., Nankivell, V., Mulangala, J., Psaltis, P., . . . Tan, J. T. M. (2024). TRIM2 Selectively Regulates Inflammation-Driven Pathological Angiogenesis without Affecting Physiological Hypoxia-Mediated Angiogenesis.
DOI
2024 Nankivell, V., Sandeman, L., Stretton, L., Vidanapathirana, A., Rajora, M., Chen, J., . . . Bursill, C. (2024). Multifunctional biomimetic porphyrin-lipid nanoparticles – novel nanoscale theranostics for atherosclerotic cardiovascular disease.
DOI
2024 Ruchka, P., Kushwaha, A., Marathe, J. A., Xiang, L., Chen, R., Kirk, R., . . . Li, J. (2024). 3D-printed axicon enables extended depth-of-focus intravascular optical
coherence tomography.
2024 Primer, K. R., Tan, J. T. M., Sandeman, L., Nankivell, V., Stretton, L. G., Solly, E., . . . Bursill, C. (2024). Reconstituted high-density lipoproteins rescue diabetes-impaired endothelial cell metabolic reprograming and angiogenic responses to hypoxia.
DOI

Diabetes Australia Research Trust 2017 General Grant

“Micromanaging” high density lipoprotein-induced rescue of diabetes-impaired angiogenesis

Date Role Research Topic Program Degree Type Student Load Student Name
2025 Co-Supervisor The role of the asialoglycoprotein receptor-1 in immune cell regulation of atherosclerosis Doctor of Philosophy Doctorate Full Time Mr Demeke Geremew Debebe
2024 Co-Supervisor Deletion of the asialoglycoprotein receptor 1 (ASGR1) to prevent athersclerotic cardiovascular disease Doctor of Philosophy Doctorate Full Time Mr Liam George Stretton

Date Role Research Topic Program Degree Type Student Load Student Name
2019 - 2023 Co-Supervisor The Role of Endothelial Cell Metabolic Reprogramming in Diabetes impaired Angiogenesis Doctor of Philosophy Doctorate Full Time Miss Khalia Rose Primer
2019 - 2023 Principal Supervisor MicroRNA-181c-5p - A Novel Therapeutic Target for the Rescue of Diabetes-Impaired Angiogenesis Doctor of Philosophy Doctorate Full Time Miss Emma Louise Solly
2018 - 2023 Co-Supervisor Investigating the theranostic properties of apoA-I-linked porphyrin-lipid nanoparticles in atherosclerosis Doctor of Philosophy Doctorate Full Time Miss Victoria Ann Nankivell

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