Dr Yassine Souilmi
ARC Grant-Funded Researcher (B)
School of Biological Sciences
Faculty of Sciences, Engineering and Technology
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
I am a postdoctoral researcher at the Australian Centre for Ancient DNA (ACAD). Prior to joining ACAD, I was trained as a bioinformatics researcher at the Department for Biomedical Informatics (DBMI) at Harvard University. I am a Fulbright alumnus and have played a significant leadership role in coordinating bioinformatics training and networks in Africa.
Currently, I lead an international team of researchers to data-mine the Online Ancient Genome Repository (OAGR)—a comprehensive centralized database containing all known ancient DNA specimens, genomes, and associated metadata. In this project, we use ancient DNA to uncover the genetic signatures of human adaptation to significant environmental, and socio-cultural changes over the last 20,000 years in Eurasia.
In addition, I am leading an effort to improve ancient DNA bioinformatic analyses and apply novel technological methods to address outstanding evolutionary questions. For instance, we are using pan-genome graphs to capture human genomic diversity omitted currently in linear reference genomes, early results using this approach showed major improvement in reducing reference bias, and improving population genomics inferences.
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Appointments
Date Position Institution name 2016 - ongoing ARC Postdoctoral Researcher University of Adelaide 2014 - 2015 Research and Teaching Assistant Harvard University 2014 - 2014 Teaching Assistant Harvard University 2013 - 2013 Adjunct Bioinformatics Instructor Mohammed V University of Rabat -
Awards and Achievements
Date Type Title Institution Name Country Amount 2013 Scholarship Fulbright Joint Supervision Doctoral Grant Harvard University United States - -
Language Competencies
Language Competency Arabic Can read, write, speak, understand spoken and peer review English Can read, write, speak, understand spoken and peer review French Can read, write, speak, understand spoken and peer review Spanish; Castilian Can read and understand spoken -
Education
Date Institution name Country Title 2012 - 2016 Mohammed V University Morocco PhD 2008 - 2011 Mohammed V University Morocco MS 2004 - 2008 Mohammed V University Morocco BS -
Research Interests
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Journals
Year Citation 2024 Elliott, C. P., Tomlinson, S., Lewandrowski, W., & Miller, B. P. (2024). Species distribution and habitat attributes guide translocation planning of a threatened short-range endemic plant. Global Ecology and Conservation, 51, 17 pages.
2024 Souilmi, Y., Wasef, S., Williams, M. P., Conroy, G., Bar, I., Bover, P., . . . Mitchell, K. J. (2024). Ancient genomes reveal over two thousand years of dingo population structure. Proceedings of the National Academy of Sciences, 121(30), e2407584121-1-e2407584121-12.
Scopus22024 Ravishankar, S., Perez, V., Davidson, R., Roca-Rada, X., Lan, D., Souilmi, Y., & Llamas, B. (2024). Filtering out the noise: metagenomic classifiers optimize ancient DNA mapping. Briefings in bioinformatics, 26(1), bbae646.
2023 Rogers, N. M., Zammit, N., Nguyen-Ngo, D., Souilmi, Y., Minhas, N., Meijles, D. N., . . . Grey, S. T. (2023). The impact of the cytoplasmic ubiquitin ligase TNFAIP3 gene variation on transcription factor NF-κB activation in acute kidney injury. Kidney international, 103(6), 1105-1119.
Scopus4 Europe PMC22023 Tobler, R., Souilmi, Y., Huber, C. D., Bean, N., Turney, C. S. M., Grey, S. T., & Cooper, A. (2023). The role of genetic selection and climatic factors in the dispersal of anatomically modern humans out of Africa.. Proc Natl Acad Sci U S A, 120(22), e2213061120.
Scopus9 Europe PMC52022 Lan, D., Purnomo, G., Tobler, R., Souilmi, Y., & Llamas, B. (2022). Genozip Dual-Coordinate VCF format enables efficient genomic analyses and alleviates liftover limitations.
2022 Roca-Rada, X., Tereso, S., Rohrlach, A. B., Brito, A., Williams, M. P., Umbelino, C., . . . Teixeira, J. C. (2022). A 1000-year-old case of Klinefelter's syndrome diagnosed by integrating morphology, osteology, and genetics.. Lancet (London, England), 400(10353), 691-692.
Scopus8 WoS1 Europe PMC32022 Souilmi, Y., Tobler, R., Johar, A., Williams, M., Grey, S. T., Schmidt, J., . . . Huber, C. D. (2022). Admixture has obscured signals of historical hard sweeps in humans. Nature Ecology & Evolution, 6(12), 2003-2015.
Scopus12 WoS3 Europe PMC182021 Oliva, A., Tobler, R., Cooper, A., Llamas, B., & Souilmi, Y. (2021). Systematic benchmark of ancient DNA read mapping. Briefings in bioinformatics, 22(5), 1-12.
Scopus17 WoS7 Europe PMC62021 Roca-Rada, X., Politis, G., Messineo, P. G., Scheifler, N., Scabuzzo, C., Gonzalez, M., . . . Fehren-Schmitz, L. (2021). Ancient mitochondrial genomes from the Argentinian Pampas inform the early peopling of the Southern Cone of South America. iScience, 24(6), 1-18.
Scopus13 WoS12 Europe PMC22021 Souilmi, Y., Lauterbur, M. E., Tobler, R., Huber, C. D., Johar, A. S., Moradi, S. V., . . . Enard, D. (2021). An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia. Current Biology, 31(16), 3504-3514.
Scopus52 WoS42 Europe PMC412021 Oliva, A., Tobler, R., Llamas, B., & Souilmi, Y. (2021). BWA-mem is not the best aligner for ancient DNA short reads.
2021 Souilmi, Y., Lauterbur, M. E., Tobler, R., Huber, C. D., Johar, A. S., Moradi, S. V., . . . Enard, D. (2021). An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia.. Curr Biol, 31(16), 3704.
Scopus4 WoS2 Europe PMC82021 Tobler, R., Souilmi, Y., Huber, C., Bean, N., Turney, C., Cooper, A., & Grey, S. (2021). Genetic and climatic factors in the dispersal of Anatomically Modern Humans Out of Africa.
2021 Cooper, A., Turney, C. S. M., Palmer, J., Hogg, A., McGlone, M., Wilmshurst, J., . . . Zech, R. (2021). Response to Comment on "A global environmental crisis 42,000 years ago". Science (New York, N.Y.), 374(6570), eabi9756.
Scopus2 Europe PMC12021 Cooper, A., Turney, C. S. M., Palmer, J., Hogg, A., McGlone, M., Wilmshurst, J., . . . Zech, R. (2021). Response to comment on “A global environmental crisis 42,000 years ago”. Science, 374(6570), 3 pages.
Scopus12021 Oliva, A., Tobler, R., Llamas, B., & Souilmi, Y. (2021). Additional evaluations show that specific
BWA‐aln
settings still outperform
BWA‐mem
for ancient DNA data alignment. Ecology and Evolution, 11(24), 18743-18748.
Scopus11 WoS1 Europe PMC92021 Cooper, A., Turney, C. S. M., Palmer, J., Hogg, A., McGlone, M., Wilmshurst, J., . . . Zech, R. (2021). A global environmental crisis 42,000 years ago. Science in China Series C: Life Sciences, 371(6531), 811-818.
Scopus67 WoS48 Europe PMC142021 Lan, D., Tobler, R., Souilmi, Y., & Llamas, B. (2021). Genozip - a universal extensible genomic data compressor. Bioinformatics, 37(16), 2225-2230.
Scopus18 WoS5 Europe PMC82020 Tobler, R., Johar, A., Huber, C., & Souilmi, Y. (2020). PolyLinkR: A linkage-sensitive gene set enrichment R package. 2020 Lan, D., Tobler, R., Souilmi, Y., & Llamas, B. (2020). genozip: a fast and efficient compression tool for VCF files. Bioinformatics, 36(13), 4091-4092.
Scopus10 WoS6 Europe PMC72020 Souilmi, Y., Tobler, R., Johar, A., Williams, M., Grey, S., Schmidt, J., . . . Cooper, A. (2020). Ancient human genomes reveal a hidden history of strong selection in Eurasia.
2020 Easteal, S., Arkell, R. M., Balboa, R. F., Bellingham, S. A., Brown, A. D., Calma, T., . . . Baynam, G. (2020). Equitable expanded carrier screening needs indigenous clinical and population genomic data. American Journal of Human Genetics, 107(2), 175-182.
Scopus25 WoS15 Europe PMC172020 Roca-Rada, X., Souilmi, Y., Teixeira, J. C., & Llamas, B. (2020). Ancient DNA studies in pre-Columbian Mesoamerica. Genes, 11(11), 1-19.
Scopus6 WoS4 Europe PMC22020 Souilmi, Y., Lauterbur, E., Tobler, R., Huber, C., Johar, A., & Enard, D. (2020). An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia.
2019 Jackson, S. M., Fleming, P. J. S., Eldridge, M. D. B., Ingleby, S., Flannery, T., Johnson, R. N., . . . Helgen, K. M. (2019). The Dogma of Dingoes—Taxonomic status of the dingo: A reply to Smith et al.. Zootaxa, 4564(1), 198-212.
Scopus39 WoS25 Europe PMC122019 Llamas, B., Narzisi, G., Schneider, V., Audano, P., Biederstedt, E., Blauvelt, L., . . . Busby, B. (2019). A strategy for building and using a human reference pangenome. F1000Research, 8, 1751.
Scopus2 Europe PMC42019 Llamas, B., Narzisi, G., Schneider, V., Audano, P., Biederstedt, E., Blauvelt, L., . . . Busby, B. (2019). A strategy for building and using a human reference pangenome. F1000Research, 8, 1751.
Scopus10 Europe PMC12019 Ahmed, A., Mpangase, P., Panji, S., Baichoo, S., Souilmi, Y., Fadlelmola, F., . . . Mulder, N. (2019). Organizing and running bioinformatics hackathons within Africa: The H3ABioNet cloud computing experience. AAS Open Res, 1, 9.
2018 Ahmed, A., Mpangase, P., Panji, S., Baichoo, S., Souilmi, Y., Fadlelmola, F., . . . Mulder, N. (2018). Organizing and running bioinformatics hackathons within Africa: The H3ABioNet cloud computing experience.
2018 Baichoo, S., Souilmi, Y., Panji, S., Botha, G., Meintjes, A., Hazelhurst, S., . . . Mulder, N. (2018). Developing reproducible bioinformatics analysis workflows for heterogeneous computing environments to support African genomics. BMC Bioinformatics, 19(1), 457-1-457-13.
Scopus27 WoS22 Europe PMC212018 Ahmed, A. E., Mpangase, P. T., Panji, S., Baichoo, S., Souilmi, Y., Fadlelmola, F. M., . . . Mulder, N. (2018). Organizing and running bioinformatics hackathons within Africa: The H3ABioNet cloud computing experience.. AAS open research, 1, 9.
Europe PMC82017 Elshazly, H., Souilmi, Y., Tonellato, P., Wall, D., & Abouelhoda, M. (2017). MC-GenomeKey: A multicloud system for the detection and annotation of genomic variants. BMC Bioinformatics, 18(1), 1-14.
Scopus11 WoS9 Europe PMC42016 Marshall, H., & Taylor, K. (2016). Up the Value Chain: Transition from Law Librarian to Research Analyst. LEGAL INFORMATION MANAGEMENT, 16(4), 207-211.
2016 Adeel, S., Azeem, M., Kamal, S., Rehman, F., Ghaffar, A., Habib, N., . . . Shabir, A. -U. (2016). MICROWAVE ASSISTED INVESTIGATION OF GOLDEN DURANTA (<i>Duranta repnes</i> L.) LEAVES AS A NATURAL COLORANT FOR SURFACE OXIDISED CELLULOSIC DYE. OXIDATION COMMUNICATIONS, 39(4), 3507-3514. 2015 Souilmi, Y., Allali, I., Badad, O., & Dwibedi, C. K. (2015). Highlights of the first ISCB Student Council Symposium in Africa 2015. F1000Research, 4, ISCB Comm J-569.
Scopus5 Europe PMC72015 Souilmi, Y., Jung, J. -Y., Lancaster, A., Gafni, E., Amzazi, S., Ghazal, H., . . . Tonellato, P. (2015). COSMOS: cloud enabled NGS analysis. BMC BIOINFORMATICS, 16(Suppl 2), 1 page.
WoS1 Europe PMC12015 Souilmi, Y., Lancaster, A., Jung, J., Rizzo, E., Hawkins, J., Powles, R., . . . Wall, D. (2015). Scalable and cost-effective NGS genotyping in the cloud. BMC Medical Genomics, 8(1), 64-1-64-9.
Scopus18 WoS17 Europe PMC142014 Gafni, E., Luquette, L. J., Lancaster, A. K., Hawkins, J. B., Jung, J. Y., Souilmi, Y., . . . Tonellato, P. J. (2014). COSMOS: Python library for massively parallel workflows. Bioinformatics (Oxford, England), 30(20), 2956-2958.
Scopus17 WoS14 Europe PMC10 -
Conference Papers
Year Citation 2024 Deshpande, A., Rogers, N., Grey, S., Souilmi, Y., & Li, J. (2024). INVESTIGATING THE ROLE OF TNFAIP3 VARIATION IN KIDNEY DISEASE. In NEPHROLOGY Vol. 29 (pp. 11). WILEY. -
Conference Items
Year Citation 2021 Souilmi, Y., Lauterbur, E., Tobler, R., Huber, C., Johar, A. S., & Enard, D. (2021). An ancient coronavirus-like epidemic 25,000 years in ancestral populations from East Asia. Poster session presented at the meeting of AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY. WILEY. -
Datasets
Year Citation - Souilmi, Y., & Tobler, R. (n.d.). Frequency data and SweepFinder2 output.
DOI -
Preprint
Year Citation 2024 Roca-Rada, X., Davidson, R., Williams, M., Ravishankar, S., Collen, E., Haarkötter, C., . . . Teixeira, J. (2024). The genetic history of Portugal over the past 5,000 years.
DOI
I have an extensive bioinformatics teaching experience, having participated in teaching activities at the University of Mohamed the Vth and at Harvard University (BMI 714) where I designed, taught and graded bioinformatics practicums between 2014 and 2016. Furthermore, I have trained, organised and ran over 25 different bioinformatics workshops in Africa, the United States, and Australia covering a wide range of basic to advanced topics.
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2024 Co-Supervisor Genomic time travel: Unravelling the evolutionary history of fauna using paleogenomics Doctor of Philosophy Doctorate Full Time Mr Shyamsundar Ravishankar -
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2021 - 2022 Co-Supervisor Advances in Genomic Data Compression Doctor of Philosophy Doctorate Full Time Mr Divon Mordechai Lan 2019 - 2022 Co-Supervisor Human demographic insights from paleogenetic studies of American and Iberian skeletal remains Doctor of Philosophy Doctorate Full Time Mr Xavier Roca Rada 2018 - 2022 Co-Supervisor Quantifying and Reducing Biases in Paleogenomic Research Doctor of Philosophy Doctorate Full Time Mr Adrien Oliva 2017 - 2022 Co-Supervisor Exploring the Genetic History of the Ancient Near East through the Bronze
and Iron AgesDoctor of Philosophy Doctorate Full Time Mr Matthew Peter Williams
Connect With Me
External Profiles