Dr Natalie Mills
Senior Lecturer in Psychiatry
Adelaide Medical School
Faculty of Health and Medical Sciences
Natalie is a Psychiatrist at the University of Adelaide, Discipline of Psychiatry. Her PhD investigated the role of cytokines and inflammatory markers in depression in adolescents.
- My Research
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- Supervision
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Natalie is a Child and Adolescent Psychiatrist. She completed her PhD in November 2016, through The University of Queensland. Natalie's PhD investigated the role of cytokines and inflammatory markers in depression in adolescents. This work examined the phenotypic and genetic relationship between inflammatory markers and depression.
Project 1:
Title: Investigating the longitudinal relationship between inflammatory markers and anxiety disorders
Description: The project examines the phenotypic and genetic relationship between inflammatory markers and anxiety-based disorders
Location: University of Adelaide, Adelaide Health and Medical Sciences building
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Appointments
Date Position Institution name 2016 - ongoing Senior Lecturer in Psychiatry University of Adelaide -
Education
Date Institution name Country Title 2016 The University of Queensland Australia PhD 1993 Monash University Australia MBBS -
Postgraduate Training
Date Title Institution Country 2009 - 2011 Certificate of Advanced Training in Child and Adolescent Psychiatry Royal Australian and New Zealand College of Psychiatrists Australia 2005 - 2005 Diploma in Clinical Psychiatry Royal College of Physicians of Ireland and Royal College of Surgeons in Ireland Ireland 2004 - 2010 FRANZCP Royal Australian and New Zealand College of Psychiatrists Australia 1996 - 2000 FRACGP Royal Australian College of General Practitioners, East Melbourne Australia -
Research Interests
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Journals
Year Citation 2025 Sampson, E., Mills, N. T., Hori, H., Cearns, M., Schwarte, K., Hohoff, C., . . . Baune, B. T. (2025). Long-term characterisation of the relationship between change in depression severity and change in inflammatory markers following inflammation-stratified treatment with vortioxetine augmented with celecoxib or placebo. Brain, Behavior, and Immunity, 123, 43-56.
2024 Loo, C., Glozier, N., Barton, D., Baune, B. T., Mills, N. T., Fitzgerald, P., . . . Rodgers, A. (2024). Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial - CORRIGENDUM. The British journal of psychiatry : the journal of mental science, 225(2), 349.
2024 Kavakbasi, E., Sampson, E., Mills, N. T., Hori, H., Schwarte, K., Hohoff, C., . . . Baune, B. T. (2024). Inflammation-stratified augmentation of vortioxetine with celecoxib: Results from a double-blind, randomized, placebo-controlled trial in major depressive disorder. Journal of Neurochemistry, 168(9), 1817-1825.
Scopus4 Europe PMC22024 Amente, L. D., Mills, N. T., Le, T. D., Hyppönen, E., & Lee, S. H. (2024). Unraveling phenotypic variance in metabolic syndrome through multi-omics. Human Genetics, 143(1), 35-47.
Scopus1 Europe PMC12024 Martin, D. M., Harvey, A. J., Baune, B., Berk, M., Carter, G. L., Dong, V., . . . Loo, C. K. (2024). Cognitive outcomes from the randomised, active-controlled Ketamine for Adult Depression Study (KADS). Journal of affective disorders, 352, 163-170.
Scopus12024 Sampson, E., Kavakbasi, E., Mills, N. T., Hori, H., Schubert, K. O., Fourrier, C., & Baune, B. T. (2024). Emotional Blunting in Depression in the PREDDICT Clinical Trial: Inflammation-Stratified Augmentation of Vortioxetine With Celecoxib. International Journal of Neuropsychopharmacology, 27(3), 11 pages.
2023 Sampson, E., Mills, N. T., Hori, H., Schwarte, K., Hohoff, C., Schubert, K. O., . . . Baune, B. T. (2023). Exploratory Analysis of the Effects of Celecoxib on Cognitive Function in Vortioxetine-Treated Patients With Major Depressive Disorder in the PREDDICT Study: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Journal of Clinical Psychiatry, 84(6), 14 pages.
Scopus1 Europe PMC12023 Loo, C., Glozier, N., Barton, D., Baune, B., Mills, N., Fitzgerald, P. B., . . . Rodgers, A. (2023). Efficacy and Safety of Repeated Subcutaneous Ketamine Injections for Treatment Resistant Depression - The KADS Study: A Randomised, Double-Blind, Comparator-Controlled Trial. British Journal of Psychiatry, 223(6), 533-541.
Scopus22 WoS6 Europe PMC102022 Baune, B. T., Sampson, E., Louise, J., Hori, H., Schubert, K. O., Clark, S. R., . . . Fourrier, C. (2022). Corrigendum to 'No evidence for clinical efficacy of adjunctive celecoxib with vortioxetine in the treatment of depression: A 6-week double-blind placebo controlled randomized trial' [European Neuropsychopharmacology 53 (2021) 34-46].. Eur Neuropsychopharmacol, 64, 61-62.
2022 Ciobanu, L. G., Stankov, L., Schubert, K. O., Amare, A. T., Jawahar, M. C., Lawrence-Wood, E., . . . Aidman, E. (2022). General intelligence and executive functioning are overlapping but separable at genetic and molecular pathway levels: An analytical review of existing GWAS findings. PLOS ONE, 17(10), e0272368.
Scopus2 Europe PMC12022 Thalamuthu, A., Mills, N. T., Berger, K., Minnerup, H., Grotegerd, D., Dannlowski, U., . . . Baune, B. T. (2022). Genome-wide interaction study with major depression identifies novel variants associated with cognitive function.. Mol Psychiatry, 27(2), 1111-1119.
Scopus30 WoS15 Europe PMC202021 Enticott, P. G., Barlow, K., Guastella, A. J., Licari, M. K., Rogasch, N. C., Middeldorp, C. M., . . . Fitzgerald, P. B. (2021). Repetitive transcranial magnetic stimulation (rTMS) in autism spectrum disorder: protocol for a multicentre randomised controlled clinical trial. BMJ Open, 11(7), e046830-1-e046830-9.
Scopus12 WoS6 Europe PMC72021 Baune, B. T., Sampson, E., Louise, J., Hori, H., Schubert, K. O., Clark, S. R., . . . Fourrier, C. (2021). No evidence for clinical efficacy of adjunctive celecoxib with vortioxetine in the treatment of depression: A 6-week double-blind placebo controlled randomized trial.. Eur Neuropsychopharmacol, 53, 34-46.
Scopus36 WoS16 Europe PMC222021 Mills, N. T., Sampson, E., Fourrier, C., & Baune, B. T. (2021). Clinical switching strategies of various antidepressants to Vortioxetine in the PREDDICT trial. The international journal of neuropsychopharmacology, 24(4), 314-321.
Scopus4 WoS2 Europe PMC12020 Fourrier, C., Sampson, E., Hori, H., Schubert, K. O., Clark, S., Mills, N. T., & Baune, B. T. (2020). Exploratory study of association between blood immune markers and cognitive symptom severity in major depressive disorder: Stratification by body mass index status. Brain, Behavior, and Immunity, 88, 242-251.
Scopus10 WoS7 Europe PMC62020 Parsons, C., Roberts, R., & Mills, N. T. (2020). Review: Inflammation and anxiety-based disorders in children and adolescents - a systematic review and meta-analysis.. Child and adolescent mental health, 26(2), 143-156.
Scopus11 WoS9 Europe PMC82019 Knight, M. J., Mills, N. T., & Baune, B. T. (2019). Contemporary methods of improving cognitive dysfunction in clinical depression.. Expert review of neurotherapeutics, 19(5), 431-443.
Scopus14 WoS7 Europe PMC42019 Ni, G., Amare, A. T., Zhou, X., Mills, N., Gratten, J., & Lee, S. H. (2019). The genetic relationship between female reproductive traits and six psychiatric disorders. Scientific Reports, 9(1), 12041-1-12041-12.
Scopus19 WoS11 Europe PMC122019 Knight, M. J., Fourrier, C., Lyrtzis, E., Aboustate, N., Sampson, E., Hori, H., . . . Baune, B. T. (2019). Cognitive deficits in the THINC-integrated tool (THINC-it) are associated with psychosocial dysfunction in patients with major depressive disorder. Journal of Clinical Psychiatry, 80(1), 18m12472-1-18m12472-8.
Scopus18 WoS10 Europe PMC82018 Ni, G., Amare, A., Zhou, X., Mills, N., Gratten, J., & Hong Lee, S. (2018). The genetic relationship between female reproductive traits and six psychiatric disorders.
2018 Fourrier, C., Sampson, E., Mills, N. T., & Baune, B. T. (2018). Anti-inflammatory treatment of depression: study protocol for a randomised controlled trial of vortioxetine augmented with celecoxib or placebo. Trials, 19(1), 447-1-447-14.
Scopus56 WoS37 Europe PMC272018 Van der Auwera, S., Peyrot, W., Milaneschi, Y., Hertel, J., Baune, B., Breen, G., . . . Grabe, H. (2018). Genome-wide gene-environment interaction in depression: a systematic evaluation of candidate genes: the childhood trauma working-group of PGC-MDD. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 177(1), 40-49.
Scopus56 WoS47 Europe PMC272018 Couvy-Duchesne, B., O'Callaghan, V., Parker, R., Mills, N., Kirk, K., Scott, J., . . . Gillespie, N. (2018). Nineteen and Up study (19Up): understanding pathways to mental health disorders in young Australian twins. BMJ open, 8(3), 1-12.
Scopus22 WoS17 Europe PMC102018 Cambridge, O., Knight, M., Mills, N., & Baune, B. (2018). The clinical relationship between cognitive impairment and psychosocial functioning in major depressive disorder: A systematic review. Psychiatry Research, 269, 157-171.
Scopus122 WoS92 Europe PMC582017 Renteria, M., Schmaal, L., Hibar, D., Couvy-Duchesne, B., Strike, L., Mills, N., . . . Hickie, I. (2017). Subcortical brain structure and suicidal behaviour in major depressive disorder: a meta-analysis from the ENIGMA-MDD working group. Translational Psychiatry, 7(5), e1116-1-e1116-7.
Scopus72 WoS59 Europe PMC462017 Schmaal, L., Hibar, D. P., Sämann, P. G., Hall, G. B., Baune, B. T., Jahanshad, N., . . . Veltman, D. J. (2017). Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group. Molecular Psychiatry, 22(6), 10 pages.
Scopus822 WoS635 Europe PMC4882017 Mills, N., Maier, R., Whitfield, J., Wright, M., Colodro-Conde, L., Byrne, E., . . . Benyamin, B. (2017). Investigating the relationship between iron and depression. Journal of Psychiatric Research, 94, 148-155.
Scopus10 WoS4 Europe PMC72016 Schmaal, L., Veltman, D., van Erp, T., Saemann, P., Frodl, T., Jahanshad, N., . . . Hibar, D. (2016). Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group. MOLECULAR PSYCHIATRY, 21(6), 806-812.
Scopus763 WoS320 Europe PMC4752015 Mills, N. T., Wright, M. J., Henders, A. K., Eyles, D. W., Baune, B. T., McGrath, J. J., . . . Vinkhuyzen, A. A. E. (2015). Heritability of transforming growth factor-β1 and tumor necrosis factor-receptor type 1 expression and vitamin D levels in healthy adolescent twins. Twin Research and Human Genetics, 18(1), 28-35.
Scopus20 WoS17 Europe PMC112013 Mills, N., Scott, J., Wray, N., Cohen-Woods, S., & Baune, B. (2013). Research review: the role of cytokines in depression in adolescents: a systematic review. Journal of Child Psychology and Psychiatry and Allied Disciplines, 54(8), 816-835.
Scopus79 WoS68 Europe PMC45 -
Conference Papers
Year Citation 2024 Mills, N., Parsons, C., Sharkey, D., Erginbas, A., Roberts, R., Scott, J., . . . Jawahar, M. (2024). INVESTIGATING THE RELATIONSHIP BETWEEN PERIPHERAL INFLAMMATORY MARKERS AND ANXIETY DISORDERS. In AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY Vol. 58 (pp. 174-175). SAGE PUBLICATIONS LTD. 2022 Clark, S. R., Mills, N., Toben, C., Jawaha, C., & Galletly, C. (2022). MENTAL HEALTH MEDICAL EDUCATION LEAD: UNIVERSITY OF ADELAIDE, ADELAIDE - EVALUATING TECHNOLOGICAL SOLUTIONS TO MENTAL HEALTH TEACHING AND ASSESSMENT DURING THE PANDEMIC. In AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY Vol. 56 (pp. 150). SAGE PUBLICATIONS LTD. 2022 Turner, M., Nasti, J., & Mills, N. (2022). AUSTRALASIAN PSYCHOPHARMACOLOGY INTEREST GROUP: 2022 UPDATE - NEW AND OLD MEDICATIONS: WHERE ARE WE UP TO?. In AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY Vol. 56 (pp. 80-81). SAGE PUBLICATIONS LTD. 2015 Schmaal, L., Veltman, D. J., van Erp, T. G. M., Penninx, B. W. J. H., Thompson, P. M., & Hibar, D. P. (2015). Subcortical Brain Alterations in Major Depressive Disorder: Findings from the ENIGMA Major Depressive Disorder Working Group. In BIOLOGICAL PSYCHIATRY Vol. 77 (pp. 1 page). Toronto, CANADA: ELSEVIER SCIENCE INC.
WoS3132015 Schmaal, L., Veltman, D. J., Van Erp, T. G., Saemann, P. G., Frodl, T., Jahanshad, N., . . . Hibar, D. P. (2015). Structural brain alterations in major depression: findings from the ENIGMA Major Depressive Disorder Working Group. In EUROPEAN NEUROPSYCHOPHARMACOLOGY Vol. 25 (pp. S394-S395). Amsterdam, NETHERLANDS: ELSEVIER SCIENCE BV.
DOI WoS1 -
Conference Items
Year Citation 2024 Martin, D., Harvey, A., Baune, B., Berk, M., Carter, G., Dong, V., . . . Loo, C. (2024). Cognitive Outcomes Following a Course of Racemic Ketamine: Results From the Randomised, Active-Controlled Ketamine for Adult Depression Study (KADS). Poster session presented at the meeting of Abstracts of the 79th Annual Meeting of the Society of Biological Psychiatry (SOBP 2024) as published in Biological Psychiatry. Austin, Texas, USA: Elsevier.
DOI2021 Turner, M., Kotze, B., & Mills, N. (2021). PSYCHOPHARMACOLOGY UPDATE: RECENT ADVANCES FOR CHILDREN AND ADOLESCENTS AND IMPLICATIONS FOR PRACTICE. Poster session presented at the meeting of AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY. SAGE PUBLICATIONS LTD. 2021 Ciobanu, L., Stankov, L., Heathcote, A., Clark, S., Breen, J., Rogasch, N., . . . Aidman, E. (2021). Mapping the genetic architectures of cognitive functioning. Poster session presented at the meeting of GeneMappers 2021. Virtual. 2020 Ciobanu, L., Schubert, O., Amare, A., Jawahar, C., Lawrence-Woods, E., Mills, N., . . . Aidman, E. (2020). P9. MAPPING THE GENETIC ARCHITECTURES OF COGNITIVE FITNESS: CAN GWAS DATA DIFFERENTIATE EXECUTIVE FUNCTIONING FROM GENERAL COGNITIVE ABILITY?. Poster session presented at the meeting of Nature Neurogenetics. New York. 2019 Baune, B., Sampson, E., Mills, N., Lyrtzis, E., Aboustate, N., Hori, H., . . . Fourrier, C. (2019). Vortioxetine with or without anti-inflammatory augmentation improves mood, cognition and functioning in MDD patients: results from the PREDDICT clinical trial. Poster session presented at the meeting of RANZCP. Hobart. 2018 Baune, B., Mills, N., Sampson, E., Aboustate, N., & Fourrier, C. (2018). Switching strategies for Vortioxetine in the PREDDICT Study. Poster session presented at the meeting of Biological Psychiatry Australia. Adelaide.
Chief Investigator A (CIA) of University of Adelaide Faculty of Health and Medical Sciences (Adelaide Medical School) Building Research Leaders Award, $39,660 (2023)
CIL of University of Adelaide Research Infrastructure funding award 'EEG system to support Psychology and Neurosciences research’, $69,804 (2022)
CIA of University of Adelaide Faculty Emerging Leaders Development Award, $37,061 (2021)
Associate Investigator (AI) - MRFF Neurological Disorders Grant Opportunity - Does repetitive transcranial magnetic stimulation (rTMS), compared to sham rTMS, improve social communication in adolescents and young adults with autism spectrum disorder (ASD) $1,903,208 (2020 - 2024)
CIA of University of Adelaide Emerging Leadership Mentored Development Program, $39,115 (2019)
AI-D of Royal Adelaide Hospital Research Committee Clinical Project Grant $40,242 (2019)
CIB of Fay Fuller Foundation Discovery Grant, $327,000 (mid 2017- mid 2019)
CIA of Pfizer Neuroscience Research Grant $44,000 (2012)
CIA QIMR Berghofer Higher Degree Travel Committee Award $700 (2012)
CIA Australian Twin Registry Research Travel Grant $600 (2012)
CIA of Royal Australian and New Zealand College of Psychiatrists Young Investigator Grant $6,000 (2010)
Teaching and co-ordinator of University of Adelaide Year 4 MBBS Psychiatry course (since January 2020)
Teaching and co-convenor of University of Adelaide Year 4 MBBS Psychiatry course (August 2016 - December 2019)
Case-based learning tutor University of Adelaide Year 3 MBBS (semester 2, 2019)
Lecturer University of Adelaide, Biological Psychiatry course (2016 - 2024)
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Other Supervision Activities
Date Role Research Topic Location Program Supervision Type Student Load Student Name 2022 - 2022 Co-Supervisor The association of anxiety symptom severity and panic attacks with inflammation University of Adelaide Psychology Honours - Aylin Erginbas 2019 - 2019 Co-Supervisor Inflammation and anxiety-based disorders in children and adolescents: a systematic review and meta-analysis The University of Adelaide, School of Psychology - Honours - Chelsea Parsons 2017 - 2017 Co-Supervisor Exploring the relationship between cognitive impairment and psychosocial functioning in Major Depressive Disorder The University of Adelaide Adelaide Medical School Honours - Olivia Cambridge
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Committee Memberships
Date Role Committee Institution Country 2023 - ongoing Member MRFF Grant Assessment Committee University of Adelaide Australia 2022 - ongoing Vice-Chair Year 4 & 5 MBBS Written Exam Committee University of Adelaide Australia 2021 - ongoing Member University of Adelaide Year 4 MBBS Written exam subcommittee University of Adelaide Australia 2021 - ongoing Member University of Adelaide Year 4 MBBS OSCE Subcommittee University of Adelaide Australia 2018 - ongoing Member Adelaide Medical School MBBS Research Committee University of Adelaide Australia 2018 - ongoing Member Faculty Seminar Series Organising Committee University of Adelaide Australia 2015 - 2015 Member Organising Committee 2015 Society for Mental Health Research Conference Society for Mental Health Research Australia 2014 - 2015 Member Scientific Program Committee 2015 Royal Australian and New Zealand College of Psychiatrists Congress Royal Australian and New Zealand College of Psychiatrists Australia 2014 - 2014 Member Organising Committee Royal Australian and New Zealand College of Psychiatrists Faculty of Child and Adolescent Psychiatry Conference Royal Australian and New Zealand College of Psychiatrists Australia 2012 - 2012 Member Royal Australian and New Zealand College of Psychiatrists, Queensland Faculty of Child and Adolescent Psychiatry Conference Organising Committee RANZCP Australia -
Community Engagement
Date Title Engagement Type Institution Country 2018 - 2018 Radio interview Scientific Community Engagement QIMR Berghofer Medical Research Institute - -
Offices Held
Date Office Name Institution Country 2014 - 2016 Child and Adolescent Psychiatrist Royal Brisbane and Women's Hospital Australia 2012 - 2014 Child and Adolescent Psychiatrist Ipswich Hospital Australia
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External Profiles