| 2025 |
Powell, J. A., & Pitson, S. M. (2025). Sphingosine 1-phosphate signalling in cancer stem cells. Oncogenesis, 14(1), 1-10. DOI |
| 2024 |
Li, M., Bennett, M. K., Toubia, J., Pope, V. S., Tea, M. N., Tamang, S., . . . Pitson, S. M. (2024). An orthotopic syngeneic mouse model of bortezomib-resistant multiple myeloma. British Journal of Haematology, 204(2), 566-570. DOI Scopus1 WoS1 Europe PMC1 |
| 2024 |
Kan, W. L., McClure, B. J., Hahn, C. N., & Powell, J. A. (2024). The 10th Barossa meeting: cell signalling to cancer medicine. Cell Death and Disease, 15(3, article no. 230), 1-3. DOI |
| 2024 |
Nwosu, G. O., Ross, D. M., Powell, J. A., & Pitson, S. M. (2024). Venetoclax therapy and emerging resistance mechanisms in acute myeloid leukaemia. Cell Death and Disease, 15(6, article no. 413), 413-1-413-11. DOI Scopus27 WoS24 Europe PMC24 |
| 2023 |
Conn, V. M., Gabryelska, M., Toubia, J., Kirk, K., Gantley, L., Powell, J. A., . . . Conn, S. J. (2023). Circular RNAs drive oncogenic chromosomal translocations within the MLL recombinome in leukemia. Cancer Cell, 41(7), 1309-1326.e10. DOI Scopus51 WoS50 Europe PMC47 |
| 2023 |
Subramanian, S., Thoms, J. A. I., Huang, Y., Cornejo Paramo, C. P., Koch, F. C., Jacquelin, S., . . . Pimanda, J. E. (2023). Genome-wide transcription factor-binding maps reveal cell-specific changes in the regulatory architecture of human HSPCs. Blood, 142(17), 1448-1462. DOI Scopus30 WoS30 Europe PMC40 |
| 2022 |
Bassal, M. A., Samaraweera, S. E., Lim, K., Benard, B. A., Bailey, S., Kaur, S., . . . D'Andrea, R. J. (2022). Author Correction: Germline mutations in mitochondrial complex I reveal genetic and targetable vulnerability in IDH1-mutant acute myeloid leukaemia.. Nat Commun, 13(1), 4131. DOI Scopus2 WoS2 Europe PMC1 |
| 2022 |
Nwosu, G. O., Powell, J. A., & Pitson, S. M. (2022). Targeting the integrated stress response in hematologic malignancies.. Experimental Hematology & Oncology, 11(1), 94. DOI Scopus12 WoS14 Europe PMC13 |
| 2022 |
Pitman, M. R., Lewis, A. C., Davies, L. T., Moretti, P. A. B., Anderson, D., Creek, D. J., . . . Pitson, S. M. (2022). The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism. Scientific Reports, 12(1), 454-1-454-12. DOI Scopus15 WoS13 Europe PMC12 |
| 2022 |
Lewis, A. C., Pope, V. S., Tea, M. N., Li, M., Nwosu, G. O., Nguyen, T. M., . . . Pitson, S. M. (2022). Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia.. Blood, 139(26), 3737-3751. DOI Scopus37 WoS32 Europe PMC35 |
| 2022 |
Bassal, M. A., Samaraweera, S. E., Lim, K., Bernard, B. A., Bailey, S., Kaur, S., . . . D'Andrea, R. J. (2022). Germline mutations in mitochondrial complex I reveal genetic and targetable vulnerability in IDH1-mutant acute myeloid leukaemia. Nature Communications, 13(1), 1-12. DOI Scopus18 WoS19 Europe PMC16 |
| 2021 |
Lewis, A. C., Wallington-Beddoe, C. T., Powell, J. A., & Pitson, S. M. (2021). Targeting sphingolipid metabolism as an approach for combination therapies in haematological malignancies (vol 4, 72, 2018). CELL DEATH DISCOVERY, 7(1), 2 pages. DOI |
| 2021 |
Bennett, M. K., Li, M., Tea, M. N., Pitman, M. R., Toubia, J., Wang, P. P. -S., . . . Pitson, S. M. (2021). Resensitising proteasome inhibitor-resistant myeloma with sphingosine kinase 2 inhibition.. Neoplasia, 24(1), 1-11. DOI Scopus16 WoS16 Europe PMC13 |
| 2020 |
Morrish, E., Copeland, A., Moujalled, D. M., Powell, J. A., Silke, N., Lin, A., . . . Brumatti, G. (2020). Clinical MDR1 inhibitors enhance Smac-mimetic bioavailability to kill murine LSCs and improve survival in AML models. Blood Advances, 4(20), 5062-5077. DOI Scopus10 WoS9 Europe PMC9 |
| 2019 |
Neubauer, H. A., Tea, M. N., Zebol, J. R., Gliddon, B. L., Stefanidis, C., Moretti, P. A. B., . . . Pitson, S. M. (2019). Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma. Oncogene, 38(8), 1151-1165. DOI Scopus26 WoS24 Europe PMC18 |
| 2019 |
Powell, J. A., Pitman, M. R., Zebol, J. R., Moretti, P. A., Neubauer, H. A., Davies, L. T., . . . Pitson, S. M. (2019). Kelch-like protein 5-mediated ubiquitination of lysine 183 promotes proteasomal degradation of sphingosine kinase 1. The Biochemical Journal, 476(21), 3211-3226. DOI Scopus14 WoS14 Europe PMC12 |
| 2019 |
Wallington-Beddoe, C., Xie, V., Tong, D., Powell, J., Lewis, A., Davies, L., . . . Bendall, L. (2019). Identification of sphingosine kinase 1 as a therapeutic target in B-lineage acute lymphoblastic leukaemia. British Journal of Haematology, 184(3), 443-447. DOI Scopus13 WoS13 Europe PMC13 |
| 2018 |
Lewis, A. C., Wallington-Beddoe, C. T., Powell, J. A., & Pitson, S. M. (2018). Targeting sphingolipid metabolism as an approach for combination therapies in haematological malignancies. Cell Death Discovery, 5(1), 4. DOI Scopus63 WoS66 Europe PMC56 |
| 2018 |
Pitson, S. M., & Powell, J. A. (2018). Modification of the tumour microenvironment via exosomal shedding of sphingosine 1-phosphate receptor 2 by breast cancer cells. OncoTarget, 9(57), 30938-30939. DOI Scopus2 Europe PMC2 |
| 2017 |
Powell, J. A., Wallington Beddoe, C. T., & Pitson, S. M. (2017). Targeting sphingosine kinase 1 in acute myeloid leukemia: translation to clinic. International journal of hematologic oncology, 6(2), 31-34. DOI Europe PMC6 |
| 2017 |
Powell, J. A., Lewis, A. C., & Pitson, S. M. (2017). The MCL-1 inhibitor S63845: an exciting new addition to the armoury of anti-cancer agents. Journal of Xiangya Medicine, 2(6), 53. DOI Scopus3 |
| 2017 |
Powell, J., Lewis, A., Zhu, W., Toubia, J., Pitman, M., Wallington-Beddoe, C., . . . Pitson, S. (2017). Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia.. Blood, 129(6), 771-782. DOI Scopus86 WoS80 Europe PMC74 |
| 2017 |
Zhu, W., Gliddon, B., Jarman, K., Moretti, P., Tin, T., Parise, L., . . . Pitson, S. (2017). CIB1 contributes to oncogenic signalling by Ras via modulating the subcellular localisation of sphingosine kinase 1. Oncogene, 36(18), 2619-2627. DOI Scopus29 WoS27 Europe PMC19 |
| 2017 |
Hein, N., Cameron, D., Hannan, K., Nguyen, N., Fong, C., Sornkom, J., . . . Hannan, R. (2017). Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population. Blood, 129(21), 2882-2895. DOI Scopus72 WoS73 Europe PMC67 |
| 2016 |
Neubauer, H. A., Pham, D. H., Zebol, J. R., Moretti, P. A. B., Peterson, A. L., Leclercq, T. M., . . . Pitson, S. M. (2016). An oncogenic role for sphingosine kinase 2. Oncotarget, 7(40), 64886-64899. DOI Scopus54 WoS50 Europe PMC52 |
| 2016 |
Smith, A. M., Dun, M. D., Lee, E. M., Harrison, C., Kahl, R., Flanagan, H., . . . Verrills, N. M. (2016). Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors. Oncotarget, 7(30), 47465-47478. DOI Scopus42 WoS41 Europe PMC35 |
| 2015 |
Lee, E., Yee, D., Busfield, S., McManus, J., Cummings, N., Vairo, G., . . . Lock, R. (2015). Efficacy of an Fc-modified anti-CD123 antibody (CSL362) combined with chemotherapy in xenograft models of acute myelogenous leukemia in immunodeficient mice. Haematologica, 100(7), 914-926. DOI Scopus60 WoS53 Europe PMC50 |
| 2015 |
Schafranek, L., Nievergall, E., Powell, J., Hiwase, D., Leclercq, T., Hughes, T., & White, D. (2015). Sustained inhibition of STAT5, but not JAK2, is essential for TKI-induced cell death in chronic myeloid leukemia. Leukemia, 29(1), 76-85. DOI Scopus30 WoS29 Europe PMC26 |
| 2015 |
Pitman, M., Powell, J., Coolen, C., Moretti, P., Zebol, J., Pham, D., . . . Pitson, S. (2015). A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties. Oncotarget, 6(9), 7065-7083. DOI Scopus65 WoS64 Europe PMC56 |
| 2014 |
Wallington-Beddoe, C., Powell, J., Tong, D., Pitson, S., Bradstock, K., & Bendall, L. (2014). Sphingosine kinase 2 promotes acute lymphoblastic leukemia by enhancing MYC expression. Cancer Research, 74(10), 2803-2815. DOI Scopus71 WoS65 Europe PMC63 |
| 2014 |
Pham, D., Powell, J., Gliddon, B., Moretti, P., Tsykin, A., Van der Hoek, M., . . . Pitson, S. (2014). Enhanced expression of transferrin receptor 1 contributes to oncogenic signalling by sphingosine kinase 1. Oncogene, 33(48), 5559-5568. DOI Scopus26 WoS25 Europe PMC23 |
| 2013 |
Schafranek, L., Nievergall, E., Powell, J., Hiwase, D., White, D., Hughes, T., & Leclercq, T. (2013). STAT5 is a critical component of the time-dependent sensitivity of CML cells to TKI treatment in a BCR-ABL-dependent, but JAK2-independent manner. Blood, 122(21), 2705. DOI WoS1 |
| 2013 |
Thomas, D., Powell, J., Green, B., Barry, E., Ma, Y., Woodcock, J., . . . Guthridge, M. (2013). Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. PLoS Biology, 11(3), 1-14. DOI Scopus20 WoS17 Europe PMC21 |
| 2013 |
Lonic, A., Powell, J., Kong, Y., Thomas, D., Holien, J., Truong, N., . . . Guthridge, M. (2013). Phosphorylation of serine 779 in fibroblast growth factor receptor 1 and 2 by protein Kinase C(epsilon) regulates Ras/mitogen-activated protein kinase signaling and neuronal differentiation. Journal of Biological Chemistry, 288(21), 14874-14885. DOI Scopus16 WoS15 Europe PMC15 |
| 2013 |
Thomas, D., Powell, J., Vergez, F., Segal, D., Nguyen, N., Baker, A., . . . Guthridge, M. (2013). Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription. Blood, 122(5), 738-748. DOI Scopus57 WoS56 Europe PMC50 |
| 2013 |
Powell, J., Pitman, M., Coolen, C., Zhu, W., Lewis, I., D'Andrea, R., . . . Lopez, A. (2013). Targeting sphingosine kinase as a therapy for acute myeloid leukaemia. Experimental Hematology, 41(8), S54. DOI |
| 2013 |
Thomas, D., Powell, J., Vergez, F., Barry, E. F., Sarry, J. E., Truong, N., . . . Guthridge, M. A. (2013). THERAPEUTIC TARGETING OF PI3K AND CDK9 IN AML. ANNALS OF HEMATOLOGY, 92, S17. |
| 2011 |
Pitson, S., Powell, J., & Bonder, C. (2011). Regulation of sphingosine kinase in hematological malignancies and other cancers. Anti-Cancer Agents in Medicinal Chemistry, 11(9), 799-809. DOI Scopus22 WoS22 Europe PMC19 |
| 2010 |
Roberts, K. G., Smith, A. M., McDougall, F., Carpenter, H., Horan, M., Neviani, P., . . . Verrills, N. M. (2010). Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers. Cancer Research, 70(13), 5438-5447. DOI Scopus125 WoS122 Europe PMC99 |
| 2010 |
Hiwase, D., White, D., Powell, J., Saunders, V., Zrim, S., Frede, A., . . . Hughes, T. (2010). Blocking cytokine signaling along with intense Bcr-Abl kinase inhibition induces apoptosis in primary CML progenitors. Leukemia, 24(4), 771-778. DOI Scopus48 WoS42 Europe PMC40 |
| 2009 |
Powell, J., Thomas, D., Barry, E., Kok, C., McClure, B., Tsykin, A., . . . Guthridge, M. (2009). Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML. Blood, 114(23), 4859-4870. DOI Scopus53 WoS51 Europe PMC49 |
| 2009 |
Barry, E., Felquer, F., Powell, J., Biggs, L., Stomski, F., Urbani, A., . . . Guthridge, M. (2009). 14-3-3:Shc scaffolds integrate phosphoserine and phosphotyrosine signaling to regulate phosphatidylinositol 3-kinase activation and cell survival. Journal of Biological Chemistry, 284(18), 12080-12090. DOI Scopus35 WoS32 Europe PMC29 |
| 2008 |
Davis, A., Carr, J., Bagley, C., Powell, J., Warrilow, D., Harrich, D., . . . Li, P. (2008). Human Immunodeficiency Virus type-1 reverse transcriptase exists as post-translationally modified forms in virions and cells. Retrovirology, 5(1), 115-1-115-12. DOI Scopus8 WoS8 Europe PMC8 |
| 2008 |
Neilsen, P., Cheney, K., Li, C., Chen, D., Noll, J., Schulz, R., . . . Callen, D. (2008). Identification of ANKRD11 as a p53 coactivator. Journal of Cell Science, 121(21), 3541-3552. DOI Scopus75 WoS71 Europe PMC68 |
| 2008 |
Hansen, G., Hercus, T., Mc Clure, B., Stomski, F., Dottore, M., Powell, J., . . . Parker, M. (2008). The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation. Cell, 134(3), 496-507. DOI Scopus270 WoS251 Europe PMC221 |
| 2006 |
Guthridge, M., Powell, J., Barry, E., Stomski, F., Mc Clure, B., Ramshaw, H., . . . Lopez, A. (2006). Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch. EMBO Journal, 25(3), 479-489. DOI Scopus72 WoS71 Europe PMC69 |
| 2005 |
Kumar, R., Neilsen, P., Crawford, J., McKirdy, R., Lee, J., Powell, J., . . . Callen, D. (2005). FBXO31 is the chromosome 16q24.3 senescence gene, a candidate breast tumor suppressor, and a component of an SCF complex. Cancer Research, 65(24), 11304-11313. DOI Scopus74 WoS74 Europe PMC63 |
| 2002 |
Powell, J., Gardner, A., Bais, A., Hinze, S., Baker, E., Whitmore, S., . . . Kremmidiotis, G. (2002). Sequencing, transcript identification, and quantitative gene expression profiling in the breast cancer loss of heterozygosity region 16q24.3 reveal three potential tumor-suppressor genes. Genomics, 80(3), 303-310. DOI Scopus41 WoS41 Europe PMC34 |
| 2002 |
Kochetkova, M., McKenzie, O., Bais, A., Martin, J., Secker, G., Seshadri, R., . . . Callen, D. (2002). CBFA2T3 (MTG16) is a putative breast tumor suppressor gene from the breast cancer loss of heterozygosity region at 16q24.3. Cancer Research, 62(16), 4599-4604. Scopus62 WoS61 Europe PMC52 |
| 2001 |
Cleton-Jansen, A., Callen, D., Seshadri, R., Goldup, S., McCallum, B., Crawford, J., . . . Cornelisse, C. (2001). Loss of heterozygosity mapping at chromosome arm 16q in 712 breast tumors reveals factors that influence delineation of candidate regions. Cancer Research, 61(3), 1171-1177. Scopus91 WoS92 Europe PMC75 |
| 2000 |
Sims, N. R., Anderson, M. F., Hobbs, L. M., Powell, J. A., & Zaidan, E. (2000). Brain mitochondrial responses to postischemic reperfusion: A role for calcium and hydrogen peroxide?. Developmental Neuroscience, 22(5-6), 366-375. DOI Scopus9 Europe PMC6 |
| 2000 |
Sims, N. R., Anderson, M. F., Hobbs, L. M., Kong, J. Y., Phillips, S., Powell, J. A., & Zaidan, E. (2000). Impairment of brain mitochondrial function by hydrogen peroxide. Molecular Brain Research, 77(2), 176-184. DOI Scopus50 Europe PMC34 |
| 1998 |
Sims, N. R., Williams, V. K., Zaidan, E., & Powell, J. A. (1998). The antioxidant defences of brain mitochondria during short-term forebrain ischemia and recirculation in the rat. Molecular Brain Research, 60(2), 141-149. DOI Scopus23 Europe PMC14 |
| 1988 |
CARPENTER, R. G., GARDNER, A., HARRIS, J., JUDD, M., LEWRY, J., MADDOCK, C. R., . . . TAYLOR, E. M. (1988). Prevention of Unexpected Infant Death: A Review of Risk‐Related Intervention in Six Centers. Annals of the New York Academy of Sciences, 533(1), 96-105. DOI Scopus9 Europe PMC7 |
| 1985 |
Powell, J. (1985). Cot deaths: keeping watch.. Community Outlook, 15-19. Scopus1 |
| 1984 |
Powell, J. (1984). Cot Deaths — can they be prevented?. Journal of the Royal Society for the Promotion of Health, 104(6), 203-205. DOI Europe PMC1 |
| 1983 |
Powell, J., Machin, D., & Kershaw, C. R. (1983). Unexpected sudden infant deaths in Gosport--some comparisons between service and civilian families.. Journal of the Royal Naval Medical Service, 69(3), 141-150. DOI Scopus5 Europe PMC4 |