Dr Megan Mitchell

Clinical Trials Manager

Adelaide Medical School

Faculty of Health and Medical Sciences

My Research
Publications
Supervision
Contact

Following post-doctoral positions at The Robinson Institute, University of Adelaide investigating peri-conception nutrition and obesity, and the consequences for fertility, pregnancy and the health of offspring (2006-2010), Dr Mitchell spent a decade in Germany. There she continued her research at the Frauenklinik des Uniklinikums, Erlangen, examining how paternal obesity influences epigenetic modifications in the embryo and placenta (2011-2012) before leaving research for a number of years to pursue a health consulting role and a MSc Psychology. Dr Mitchell effectively translated her research skills to provide evidence-based, weight-neutral nutrition and health strategy consulting (2014-2019) before relocating back to Adelaide. Since 2021, she has worked alongside Professor Jodie Dodd at Adelaide's Women's and Children's Hospital as a Clinical Research Manager, actively involved in managing clinical research and randomised controlled trials for women before and during pregnancy.

Journals

Year	Citation
2025	Poprzeczny, A. J., Deussen, A. R., Mitchell, M., Slade, L., Louise, J., & Dodd, J. M. (2025). Antenatal Physical Activity Interventions and Pregnancy Outcomes: A Systematic Review and Meta-Analysis With a Focus on Trial Quality. BJOG: An International Journal of Obstetrics and Gynaecology, 15 pages. DOI
2024	Dodd, J. M., Louise, J., Deussen, A. R., Mitchell, M., & Poston, L. (2024). Rethinking causal assumptions about maternal BMI, gestational weight gain, and adverse pregnancy outcomes. BMC Medicine, 22(1), 197-1-197-12. DOI Scopus6 Europe PMC2
2024	Dodd, J. M., Deussen, A. R., Mitchell, M., & Louise, J. (2024). Regular weighing of pregnant women: a relic from a bygone era. Obesity, 32(9), 1611-1612. DOI Scopus1
2024	Dodd, J. M., Deussen, A. R., Poprzeczny, A. J., Slade, L. J., Mitchell, M., & Louise, J. (2024). Investigating discrepancies in findings between rigorous randomized trials and meta-analyses evaluating pregnancy interventions to limit gestational weight gain. Obesity Reviews, 25(12), e13826-1-e13826-24. DOI Scopus1
2023	Dodd, J. M., Deussen, A. R., Peña, A. S., Mitchell, M., & Louise, J. (2023). Effects of an antenatal dietary intervention in women with obesity or overweight on child outcomes at 8–10 years of age: LIMIT randomised trial follow-up. BMC Pediatrics, 23(1), 1-11. DOI Scopus3
2022	Dodd, J. M., Deussen, A. R., Mitchell, M., Poprzeczny, A. J., & Louise, J. (2022). Maternal overweight and obesity during pregnancy: strategies to improve outcomes for women, babies, and children. Expert Review of Endocrinology and Metabolism, 17(4), 343-349. DOI Scopus8 WoS4 Europe PMC2
2021	Bernhardt, L., Dittrich, M., El-Merahbi, R., Saliba, A. E., Müller, T., Sumara, G., . . . El Hajj, N. (2021). A genome-wide transcriptomic analysis of embryos fathered by obese males in a murine model of diet-induced obesity. Scientific Reports, 11(1), 7 pages. DOI Scopus8 WoS6 Europe PMC6
2017	Mitchell, M., Strick, R., Strissel, P., Dittrich, R., McPherson, N., Lane, M., . . . El Hajj, N. (2017). Gene expression and epigenetic aberrations in F1-placentas fathered by obese males. Molecular Reproduction and Development, 84(4), 316-328. DOI Scopus25 WoS23 Europe PMC18
2017	Van Wettere, W. H. E. J., Mitchell, M., Revell, D. K., & Hughes, P. E. (2017). Pre- and peri-pubertal feed intake: effects on age at puberty and potential litter size of replacement gilts. Animal Production Science, 57(6), 1040-1046. DOI
2015	Henke, C., Strissel, P. L., Schubert, M. T., Mitchell, M., Stolt, C. C., Faschingbauer, F., . . . Strick, R. (2015). Selective expression of sense and antisense transcripts of the sushi-ichi-related retrotransposon - derived family during mouse placentogenesis. Retrovirology, 12(1), 17 pages. DOI Scopus31 WoS28 Europe PMC22
2013	Fullston, T., Ohlsson Teague, E., Mc Pherson, N., De Blasio, M., Mitchell, M., Corbett, M., . . . Lane, M. (2013). Paternal obesity initiates metablic disturbances in two generations of mice with incomplete penetrance to the F₂ generation and alters the transcriptional profile of testis and sperm microRNA content. FASEB Journal, 27(10), 4226-4243. DOI Scopus486 WoS390 Europe PMC303
2013	Smits, R., Luxford, B., Mitchell, M., & Nottle, M. (2013). Embryo survival, but not first-parity litter size, is increased when gilts are fed diets supplemented with omega-3 fatty acids from fish oil. Animal Production Science, 53(1), 57-66. DOI Scopus4 WoS3
2012	Campbell, J., Nottle, M., Vassiliev, I., Mitchell, M., & Lane, M. (2012). Insulin increases epiblast cell number of in vitro cultured mouse embryos via the PI3K/GSK3/p53 pathway. Stem Cells and Development, 21(13), 2430-2441. DOI Scopus20 WoS19 Europe PMC16
2012	Binder, N., Mitchell, M., & Gardner, D. (2012). Parental diet-induced obesity leads to retarded early mouse embryo development and altered carbohydrate utilisation by the blastocyst. Reproduction Fertility and Development, 24(6), 804-812. DOI Scopus64 WoS60 Europe PMC46
2012	Fullston, T., Mc Pherson, N., Owens, J., Mitchell, M., Bakos, H., & Lane, M. (2012). Diet-induced paternal obesity in the absence of diabetes diminishes the reproductive health of two subsequent generations of mice. Human Reproduction, 27(5), 1391-1400. DOI Scopus171 WoS143 Europe PMC112
2011	Smits, R., Luxford, B., Mitchell, M., & Nottle, M. (2011). Sow litter size is increased in the subsequent parity when lactating sows are fed diets containing n-3 fatty acids from fish oil. Journal of Animal Science, 89(9), 2731-2738. DOI Scopus46 WoS37 Europe PMC23
2011	Mc Pherson, N., Fullston, T., Mitchell, M., Setchell, B., & Lane, M. (2011). SIRT6 in mouse spermatogenesis is modulated by diet-induced obesity. Reproduction Fertility and Development, 23(7), 929-939. DOI Scopus88 WoS71 Europe PMC58
2011	Campbell, J., Mitchell, M., Nottle, M., & Lane, M. (2011). Development of a mouse model for studying the effect of embryo culture on embryonic stem cell derivation. Stem Cells and Development, 20(9), 1578-1587. DOI Scopus5 WoS4 Europe PMC3
2011	Fullston, T., Mitchell, M., Wakefield, S., & Lane, M. (2011). Mitochondrial inhibition during preimplantation embryogenesis shifts the transcriptional profile of fetal mouse brain. Reproduction Fertility and Development, 23(5), 691-701. DOI Scopus9 WoS8 Europe PMC8
2011	Mitchell, M., Bakos, H., & Lane, M. (2011). Paternal diet-induced obesity impairs embryo development and implantation in the mouse. Fertility and Sterility, 95(4), 1349-1353. DOI Scopus130 WoS117 Europe PMC86
2011	Bakos, H., Henshaw, R., Mitchell, M., & Lane, M. (2011). Paternal body mass index is associated with decreased blastocyst development and reduced live birth rates following assisted reproductive technology. Fertility and Sterility, 95(5), 1700-1704. DOI Scopus192 WoS155 Europe PMC113
2011	Van Wettere, W., Mitchell, M., Revell, D., & Hughes, P. (2011). Nutritional restriction of pre-pubertal liveweight gain impairs ovarian follicle growth and oocyte developmental competence of replacement gilts. Theriogenology, 75(7), 1301-1310. DOI Scopus12 WoS10 Europe PMC4
2011	Wakefield, S., Lane, M., & Mitchell, M. (2011). Impaired mitochondrial function in the preimplantation embryo perturbs fetal and placental development in the mouse. Biology of Reproduction, 84(3), 572-580. DOI Scopus94 WoS80 Europe PMC61
2011	Bakos, H., Mitchell, M., Setchell, B., & Lane, M. (2011). The effect of paternal diet-induced obesity on sperm function and fertilization in a mouse model. International Journal of Andrology, 34(5), 402-410. DOI Scopus224 WoS182 Europe PMC134
2010	Zander, D., Mitchell, M., Thompson, J., & Lane, M. (2010). Alterations in mouse embryo intracellular pH by DMO during culture impair implantation and fetal growth. Reproductive BioMedicine Online, 21(2), 219-229. DOI Scopus32 WoS26 Europe PMC17
2009	Mitchell, M., Schulz, S., Armstrong, D., & Lane, M. (2009). Metabolic and Mitochondrial Dysfunction in Early Mouse Embryos Following Maternal Dietary Protein Intervention. Biology of Reproduction, 80(4), 622-630. DOI Scopus71 WoS68 Europe PMC53
2009	Mitchell, M., Cashman, K., Gardner, D., Thompson, J., & Lane, M. (2009). Disruption of Mitochondrial Malate-Aspartate Shuttle Activity in Mouse Blastocysts Impairs Viability and Fetal Growth. Biology of Reproduction, 80(2), 295-301. DOI Scopus66 WoS52 Europe PMC44
2008	Lane, M., Mitchell, M., Cashman, K., Inglis, D., Wakefield, S., & Zander, D. (2008). To QC or not to QC: the key to a consistent laboratory?. Reproduction Fertility and Development, 20(1), 23-32. DOI Scopus56 WoS45 Europe PMC30
2008	Wakefield, S., Lane, M., Schulz, S., Hebart, M., Thompson, J., & Mitchell, M. (2008). Maternal supply of omega 3 polyunsaturated fatty acids alter mechanisms involved in oocyte and early embryo development in the mouse. American Journal of Physiology-Endocrinology and Metabolism, 294(2), E425-E434. DOI Scopus137 WoS123 Europe PMC86
2007	Thompson, J., Mitchell, M., & Kind, K. (2007). Embryo culture and long-term consequences. Reproduction Fertility and Development, 19(1), 43-52. DOI Scopus64 WoS55 Europe PMC38
2006	Van Wettere, W., Revell, D., Mitchell, M., & Hughes, P. (2006). Increasing the age of gilts at first boar contact improves the timing and synchrony of the pubertal response but does not affect potential litter size. Animal Reproduction Science, 95(1-2), 97-106. DOI Scopus33 WoS30 Europe PMC15
2006	McDowall, M., Mitchell, M., Cetica, P., Dalvit, G., Pantaleon, M., Lane, M., . . . Thompson, J. (2006). Glucosamine supplementation during in vitro maturation inhibits subsequent embryo development: Possible role of the hexosamine pathway as a regulator of developmental competence.. Biology of Reproduction, 74(5), 881-888. DOI Scopus42 WoS40 Europe PMC34
2005	Mitchell, M., & Lane, M. (2005). Dietary protein does not influence mitochondrial distribution in the 2-cell mouse embryo. Reproduction Fertility and Development, 17(Suppl.), 126. DOI
2005	Mitchell, M., Armstrong, D., Robker, R., & Norman, R. (2005). Adipokines: implications for female fertility and obesity. Reproduction, 130(5), 583-597. DOI Scopus246 WoS203 Europe PMC146
2005	Mitchell, M., Revell, D., Bawden, C., & Hynd, P. (2005). Keratin gene expression in Merino sheep with divergent wool growth. Australian Journal of Agricultural Research, 56(3), 203-210. DOI Scopus3 WoS3
2004	Mitchell, M., O'Leary, S., Brooke, G., Maddocks, S., & Armstrong, D. (2004). Novel immune modulation to improve reproductive outcomes in pigs. Reproduction Fertility and Development, 16(Suppl.), 230. DOI
2002	Mitchell, M., Revell, D., Bawden, C., & Hynd, P. (2002). Merino sheep selected for divergent fleece weight do not differ in the proportion of sulphur-containing keratin wool proteins. Animal Production, 24, 276.
2000	Mitchell, M., Revell, D., Ingham, V., & Hynd, P. (2000). Nutrient partitioning between wool and meat production in merino phenotypes. Asian-Australasian Journal of Animal Sciences, 13, 162.

Conference Papers

Year	Citation
2010	Fullston, T., Mitchell, M., Owens, J., Palmer, N., Bakos, H., & Lane, M. (2010). Paternal Obesity Affects Male Offspring's Health and Sperm Function. In AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY Vol. 50 (pp. 22). WILEY-BLACKWELL PUBLISHING, INC. WoS2
2009	Fullston, T., Mitchell, M., Wakefield, S., Filby, A., & Lane, M. (2009). Micro-Array Analysis of Fetal Mouse Brain Following Induction of Mitochondrial Dysfunction During Pre-Implantation Embryo Development.. In BIOLOGY OF REPRODUCTION (pp. 102). Pittsburgh, PA: SOC STUDY REPRODUCTION.
2008	Wakefield, S., Lane, M., & Mitchell, M. (2008). Mitochondrial dysfunction of the early mouse embryo increases expression of SNF2 family genes. In BIOLOGY OF REPRODUCTION Vol. 78 (pp. 132-133). Kona, HI: SOC STUDY REPRODUCTION. DOI
2008	Mitchell, M., Georgiou, A., Cashman, K., Stump, A., & Lane, M. (2008). Do sirtuin proteins function in the developing mammalian embryo?. In BIOLOGY OF REPRODUCTION Vol. 78 (pp. 134). Kona, HI: SOC STUDY REPRODUCTION. DOI WoS2
2006	Van Wettere, W., Revell, D., Mitchell, M., & Hughes, P. (2006). The influence of growth rate on ovarian characteristics of pre-pubertal gilts. In Proceedings of the VIIth International Conference on Pig Reproduction (pp. 0 pages). Kerkrade, The Netherlands: Nottingham University Press.
2006	Van Wettere, W., Revell, D., Mitchell, M., & Hughes, P. (2006). Gilt age at first boar contact affects the pubertal response but not potential litter size. In Proceedings of the VIIth International Conference on Pig Reproduction (pp. 0 pages). Kerkrade, The Netherlands: Nottingham University Press.
2006	Mitchell, M., Schulz, S., Hickey, T., Armstrong, D., & Grupen, C. (2006). Dihydrotestosterone (DHT) differentially influences nuclear and cytoplasmic maturation of pig oocytes from different sized follicles. In Proceedings of the VIIth International Conference on Pig Reproduction (pp. 0 pages). United Kingdom: Nottingham University Press.
2005	Van Wettere, W., Mitchell, M., Revell, D., & Hughes, P. (2005). Live weight gain affects gilt reproductive performance. In J. Paterson (Ed.), Manipulating pig production X : proceedings of the Tenth Biennial Conference of the Australasian Pig Science Association (Inc.) (pp. Unknown). New Zealand: Australasian Pig Science Association.
2005	Van Wettere, W., Mitchell, M., Revell, D., & Hughes, P. (2005). Management and nutritional factors affecting puberty attainment and first litter size in replacement gilts. In J. Paterson (Ed.), Proceedings of the Tenth Biennial Conference of the Australasian Pig Science Association (Inc.) (pp. 180-187). Werribee, Victoria, Australia: Australasian Pig Science Association (INC.).
2005	Van Wettere, W., Mitchell, M., Schulz, S., Revell, D., & Hughes, P. (2005). The effect of growth characteristics on the ovarian follicle population of pre-pubertal gilts. In J. Paterson (Ed.), Proceedings of the Tenth Biennial Conference of the Australasian Pig Science Association (Inc.) (pp. 201). Werribee, Victoria, Australia: Australasian Pig Science Association (INC.).
2004	Ferres, V., Nattrass, G., Mitchell, M., Penno, N., & Hynd, P. (2004). Expression of SPARC (secreted protein acidic rich in cysteine) throughout the hair cycle in rats. In Fourth Intercontinental Meeting of Hair Research Societies : Abstracts, 17-19 June, 2004: 1p.. Berlin, Germany.

Conference Items

Year	Citation
2011	Owens, J. A., Fullston, T., Mitchell, M., Palmer, N., Bakos, H., & Lane, M. (2011). Diet Induced Paternal Obesity Impairs the Metabolic and Reproductive Health of Two Subsequent Generations. Poster session presented at the meeting of JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE. CAMBRIDGE UNIV PRESS.
2006	Mitchell, M., Schulz, S. J., Hamon, R., Armstrong, D. T., & Lane, M. (2006). The influence of maternal dietary protein supply on oocyte quality and mitochondrial homeostasis of in vivo and in vitro produced mouse embryos.. Poster session presented at the meeting of BIOLOGY OF REPRODUCTION. Univ Nebraska Med Ctr, Omaha, NE: SOC STUDY REPRODUCTION.

Past Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2009 - 2012	Co-Supervisor	The Functional Role and Requirement for Long-Chain Omega-3 Polyunsaturated Fatty Acids in Breeding Gilts and Sows	Doctor of Philosophy	Doctorate	Part Time	Mr Robert John Christian Smits
2005 - 2008	Co-Supervisor	Management and Nutrition of the Replacement Gilt	Doctor of Philosophy	Doctorate	Part Time	APrf William Van Wettere

Position: Clinical Trials Manager
Phone: 83131389
Email: megan.mitchell@adelaide.edu.au
Campus: Women's & Children's Hospital
Building: Queen Victoria Building, floor First Floor
Org Unit: Women's and Children's Health

Dr Megan Mitchell

Journals

Conference Papers

Conference Items

Past Higher Degree by Research Supervision (University of Adelaide)

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