Jeremy Thompson
School of Biomedicine
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
My overall research interest is the impact of the micro-environment surrounding oocytes and embryos, especially nutritional factors, within both the in vivo (follicular/oviduct/uterine) and in vitro environment. This encompasses the following research:
Hypoxia, Hypoxia inducible factors and their role in reproduction
My laboratory has had a long standing interest in the role of oxygen concentration in regulating events within the female reproductive tract. This is primarily because both oocytes (within follicles) and pre-implantation stage embryos (especially within the uterus) develop in what is normally considered low oxygen concentration environments. We have focussed on the role of the transcription factor, Hypoxia Inducible Factor, in regulating a number of transitional events, such as follicle antrum formation, corpus luteum formation, early embryo development and implantation.
Glucose concentration, the hexosamine biosynthesis pathway and oocyte competence.
My laboratory has been investigating the less well-recognized pathway of glucose metabolism, the hexosamine biosynthesis pathway and its relationship between oocyte and early embryo competence. My laboratory has found that in both oocytes and embryos are sensitive to increased hyperglycemia through the O-linked-β-glycosylation of intracellular proteins. This has relevance to the negative impact that diabetes is known to have on reproductive health.
Oocyte secreted factors and oocyte competence.
With my collaborators, my laboratory has been studying cumulus cell – oocyte interactions and the role of oocyte secreted factors (OSFs). This has led to the discovery that the addition of native OSFs or the addition of recombinant specific factors, growth differentiation factor-9 (GDF-9) or bone morphogenetic protein-15 (BMP-15) to in vitro maturation of cattle or mouse oocytes significantly increases subsequent embryo yield by 50% and improves quality of resultant embryos and increases implantation rates post-transfer. This discovery is now patented and licensed to Cook Medical. We are pursuing this research area further and our aim is to apply this discovery to clinical IVM.
“The Spark of Life”
Within the ARC Centre for Nanoscale BioPhotonics, I lead a theme that examines the application of photonics and fluorescence sensing technologies to early developmental events, in particular oocyte maturation and fertilization. The aim here is to measure critical events in early development in real-time and in situ, and to develop new devices that can be used to measure reproductive health within one's own home.
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Awards and Achievements
Date Type Title Institution Name Country Amount 2018 Award ARC Centre for Nanoscale BioPhotonics Director's Award 2019 ARC Centre of Excellence for Nanoscale BioPhotonics Australia - 2016 Distinction 2016 Society for Reproductive Biology Founders Lecture Society for Reproductive Biology Australia - 2016 Award Society Reproductive Biology Founder’s Lecturer - - - 2014 Award Robinson Research Institute (University of Adelaide) Service Award - - - 2013 Achievement Made a Fellow of the Society for Reproductive Biology - - - 2012 Award Mentorship Award - - - 2007 Award Mentorship Award - - - 2000 Award New Zealand Society of Animal Production Animal Science Award - - - 1998 Award New Zealand Society of Animal Production Animal Science Award - - - 1993 Award Recipient Prince and Princess of Wales Science Award - - - 1993 Award McLaughlin Trust Award - - - 1993 Fellowship AgResearch Travel Fellowship - - - 1989 Award New Zealand Society of Animal Production’s Young Members Award - - - -
Research Interests
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Journals
Year Citation 2015 Kind, K., Tam, K., Banwell, K., Gauld, A., Russell, D., Macpherson, A., . . . Thompson, J. (2015). Oxygen-regulated gene expression in murine cumulus cells. Reproduction, Fertility and Development, 27(2), 407-418.
Scopus17 WoS15 Europe PMC112014 Sudiman, J., Sutton-McDowall, M., Ritter, L., White, M., Mottershead, D., Thompson, J., & Gilchrist, R. (2014). Bone morphogenetic protein 15 in the pro-mature complex form enhances Bovine oocyte developmental competence. PLoS One, 9(7), e103563-1-e103563-11.
Scopus47 WoS38 Europe PMC262014 Richani, D., Wang, X., Zeng, H., Smitz, J., Thompson, J., & Gilchrist, R. (2014). Pre-maturation with cAMP modulators in conjunction with EGF-like peptides during in vitro maturation enhances mouse oocyte developmental competence. Molecular Reproduction and Development, 81(5), 422-435.
Scopus65 WoS54 Europe PMC402014 Richani, D., Sutton-McDowall, M., Frank, L., Gilchrist, R., & Thompson, J. (2014). Effect of epidermal growth factor-like peptides on the metabolism of in vitro matured mouse oocytes and cumulus cells. Biology of Reproduction, 90(3), 49.
Scopus46 WoS34 Europe PMC342014 Frank, L., Sutton-McDowall, M., Gilchrist, R., & Thompson, J. (2014). The effect of peri-conception hyperglycaemia and the involvement of the hexosamine biosynthesis pathway in mediating oocyte and embryo developmental competence. Molecular Reproduction and Development, 81(5), 391-408.
Scopus16 WoS14 Europe PMC122014 Sugimura, S., Ritter, L., Sutton-McDowall, M., Mottershead, D., Thompson, J., & Gilchrist, R. (2014). Amphiregulin cooperates with bone morphogenetic protein 15 to increase oocyte developmental competence by gap junction-mediated enhanced metabolite supply. Molecular Human Reproduction, 20(6), 499-513.
Scopus70 WoS58 Europe PMC492014 Zeng, H., Richani, D., Sutton-McDowall, M., Ren, Z., Smitz, J., Stokes, Y., . . . Thompson, J. (2014). Prematuration with cyclic adenosine monophosphate modulators alters cumulus cell and oocyte metabolism and enhances developmental competence of in vitro-matured mouse oocytes. Biology of Reproduction, 91(2), 1-11.
Scopus64 WoS60 Europe PMC442014 Frank, L., Sutton-McDowall, M., Brown, H., Russell, D., Gilchrist, R., & Thompson, J. (2014). Hyperglycaemic conditions perturb mouse oocyte in vitro developmental competence via beta-O-linked glycosylation of Heat shock protein 90. Human Reproduction, 29(6), 1292-1303.
Scopus31 WoS22 Europe PMC252014 Gutnisky, C., Dalvit, G., Thompson, J., & Cetica, P. (2014). Pentose phosphate pathway activity: effect on in vitro maturation and oxidative status of bovine oocytes. Reproduction Fertility and Development, 26(7), 931-942.
Scopus24 WoS16 Europe PMC192014 McDowall, M., Yelland, R., MacMillan, K., Robker, R., & Thompson, J. (2014). A study relating the composition of follicular fluid and blood plasma from individual Holstein dairy cows to the in vitro developmental competence of pooled abattoir-derived oocytes. Theriogenology, 82(1), 95-103.
Scopus10 WoS7 Europe PMC52014 Sudiman, J., Ritter, L., Inglis, D., Wang, X., Chan, K., Mottershead, D., . . . Gilchrist, R. (2014). Effects of differing oocyte-secreted factors during mouse in vitro maturation on subsequent embryo and fetal development. Journal of Assisted Reproduction and Genetics, 31(3), 295-306.
Scopus50 WoS43 Europe PMC282013 Thompson, J., & Gilchrist, R. (2013). Pioneering contributions by Robert Edwards to oocyte in vitro maturation (IVM). Molecular Human Reproduction, 19(12), 794-798.
Scopus9 WoS5 Europe PMC62013 Heng, S., McDevitt, C., Stubing, D., Whittall, J., Thompson, J., Engler, T., . . . Monro, T. (2013). Microstructured optical fibers and live cells: a water-soluble, photochromic zinc sensor. Biomacromolecules, 14(10), 3376-3379.
Scopus29 WoS24 Europe PMC52013 Kind, K., Banwell, K., Gebhardt, K., Macpherson, A., Gauld, A., Russell, D., & Thompson, J. (2013). Microarray analysis of mRNA from cumulus cells following in vivo or in vitro maturation of mouse cumulus-oocyte complexes. Reproduction Fertility and Development, 25(2), 426-438.
Scopus33 WoS28 Europe PMC272013 Richani, D., Ritter, L., Thompson, J., & Gilchrist, R. (2013). Mode of oocyte maturation affects EGF-like peptide function and oocyte competence. Molecular Human Reproduction, 19(8), 500-509.
Scopus55 WoS43 Europe PMC392013 Caixeta, E., McDowall, M., Gilchrist, R., Thompson, J., Price, C., Machado, M., . . . Buratini, J. (2013). Bone morphogenetic protein 15 and fibroblast growth factor 10 enhance cumulus expansion, glucose uptake, and expression of genes in the ovulatory cascade during in vitro maturation of bovine cumulus-oocyte complexes. Reproduction, 146(1), 27-35.
Scopus85 WoS74 Europe PMC472013 Zeng, H., Ren, Z., Guzman, L., Wang, X., McDowall, M., Ritter, L., . . . Gilchrist, R. (2013). Heparin and cAMP modulators interact during pre-in vitro maturation to affect mouse and human oocyte meiosis and developmental competence. Human Reproduction, 28(6), 1536-1545.
Scopus70 WoS63 Europe PMC452013 Morado, S., Cetica, P., Beconi, M., Thompson, J., & Dalvit, G. (2013). Reactive oxygen species production and redox state in parthenogenetic and sperm-mediated bovine oocyte activation. Reproduction, 145(5), 471-478.
Scopus27 WoS24 Europe PMC132013 Rose, R., Gilchrist, R., Kelly, J., Thompson, J., & McDowall, M. (2013). Regulation of sheep oocyte maturation using cAMP modulators. Theriogenology, 79(1), 142-148.
Scopus70 WoS64 Europe PMC442013 Gutnisky, C., Morado, S., Dalvit, G., Thompson, J., & Cetica, P. (2013). Glycolytic pathway activity: effect on IVM and oxidative metabolism of bovine oocytes. Reproduction Fertility and Development, 25(7), 1026-1035.
Scopus31 WoS25 Europe PMC202013 Frank, L., McDowall, M., Russell, D., Wang, X., Inglis, D., Gilchrist, R., & Thompson, J. (2013). Effect of varying glucose and glucosamine concentration in vitro on mouse oocyte maturation and developmental competence. Reproduction Fertility and Development, 25(8), 1095-1104.
Scopus15 WoS13 Europe PMC112013 Schelbach, C., Robker, R., Bennett, B., Gauld, A., Thompson, J., & Kind, K. (2013). Altered pregnancy outcomes in mice following treatment with the hyperglycaemia mimetic, glucosamine, during the periconception period. Reproduction Fertility and Development, 25(2), 405-416.
Scopus15 WoS13 Europe PMC122012 Dunning, K., Watson, L., Sharkey, D., Brown, H., Norman, R., Thompson, J., . . . Russell, D. (2012). Molecular filtration properties of the mouse expanded cumulus matrix: controlled supply of metabolites and extracellular signals to cumulus cells and the oocyte. Biology of Reproduction, 87(4), 1-10.
Scopus23 WoS23 Europe PMC152012 McDowall, M., Mottershead, D., Gardner, D., Gilchrist, R., & Thompson, J. (2012). Metabolic differences in bovine cumulus-oocyte complexes matured in vitro in the presence or absence of follicle-stimulating hormone and bone morphogenetic protein 15. Biology of Reproduction, 87(4), 1-8.
Scopus43 WoS36 Europe PMC302012 McDowall, M., Inglis, D., Robker, R., Thompson, J., & Dunning, K. (2012). Utilization of endogenous fatty acid stores for energy production in bovine preimplantation embryos. Theriogenology, 77(8), 1632-1641.
Scopus99 WoS88 Europe PMC592011 Gilchrist, R., Mottershead, D., & Thompson, J. (2011). Oocyte maturation and ovulation - an orchestral symphony of signalling. Australian Biochemist, 42(1), 8-11. 2011 Clark, A., Stokes, Y., & Thompson, J. (2011). Estimation of glucose uptake by ovarian follicular cells. Annals of Biomedical Engineering, 39(10), 2654-2667.
Scopus13 WoS13 Europe PMC112011 Robertson, S., Chin, P., Glynn, D., & Thompson, J. (2011). Peri-conceptual cytokines - Setting the trajectory for embryo implantation, pregnancy and beyond. American Journal of Reproductive Immunology (Print), 66(Suppl 1), 2-10.
Scopus70 WoS49 Europe PMC412011 Hussein, T., McDowall, M., Gilchrist, R., & Thompson, J. (2011). Temporal effects of exogenous oocyte-secreted factors on bovine oocyte developmental competence during IVM. Reproduction Fertility and Development, 23(4), 576-584.
Scopus49 WoS43 Europe PMC312011 Smitz, J., Thompson, J., & Gilchrist, R. (2011). The promise of in vitro maturation in assisted reproduction and fertility preservation. Seminars in Reproductive Medicine, 29(1), 24-37.
Scopus135 WoS120 Europe PMC942011 Gilchrist, R. B., De Vos, M., Smitz, J., & Thompson, J. G. (2011). IVM media are designed specifically to support immature cumulus-oocyte complexes not denuded oocytes that have failed to respond to hyperstimulation. Fertility and Sterility, 96(2), E141.
Scopus13 WoS7 Europe PMC52010 Dunning, K., Cashman, K., Russell, D., Thompson, J., Norman, R., & Robker, R. (2010). Beta-oxidation is essential for mouse oocyte developmental competence and early embryo development. Biology of Reproduction, 83(6), 909-918.
Scopus353 WoS297 Europe PMC2492010 Sousa Lopes, A., Lane, M., & Thompson, J. (2010). Oxygen consumption and ROS production are increased at the time of fertilization and cell cleavage in bovine zygotes. Human Reproduction, 25(11), 2762-2773.
Scopus88 WoS76 Europe PMC652010 Albuz, F., Sasseville, M., Lane, M., Armstrong, D., Thompson, J., & Gilchrist, R. (2010). Simulated physiological oocyte maturation (SPOM): a novel in vitro maturation system that substantially improves embryo yield and pregnancy outcomes. Human Reproduction, 25(12), 2999-3011.
Scopus236 WoS200 Europe PMC1582010 Tam, K., Russell, D., Peet, D., Bracken, C., Rodgers, R., Thompson, J., & Kind, K. (2010). Hormonally regulated follicle differentiation and luteinization in the mouse is associated with hypoxia inducible factor activity. Molecular and Cellular Endocrinology, 327(1-2), 47-55.
Scopus44 WoS39 Europe PMC332010 Zander, D., Mitchell, M., Thompson, J., & Lane, M. (2010). Alterations in mouse embryo intracellular pH by DMO during culture impair implantation and fetal growth. Reproductive BioMedicine Online, 21(2), 219-229.
Scopus32 WoS26 Europe PMC202010 Schelbach, C., Kind, K., Lane, M., & Thompson, J. (2010). Mechanisms contributing to the reduced developmental competence of glucosamine-exposed mouse oocytes. Reproduction Fertility and Development, 22(5), 771-779.
Scopus18 WoS14 Europe PMC152010 McDowall, M., Gilchrist, R., & Thompson, J. (2010). The pivotal role of glucose metabolism in determining oocyte developmental competence. Reproduction, 139(4), 685-695.
Scopus414 WoS336 Europe PMC2962010 Tunc, O., Thompson, J., & Tremellen, K. (2010). Development of the NBT assay as a marker of sperm oxidative stress. International Journal of Andrology, 33(1), 13-21.
Scopus82 WoS69 Europe PMC452010 Pringle, K., Kind, K., Sferruzzi-Perri, A., Thompson, J., & Roberts, C. (2010). Beyond oxygen: complex regulation and activity of hypoxia inducible factors in pregnancy. Human Reproduction Update, 16(4), 415-431.
Scopus223 WoS188 Europe PMC1612009 Jansen, S., Cashman, K., Thompson, J., Pantaleon, M., & Kaye, P. (2009). Glucose deprivation, oxidative stress and peroxisome proliferator-activated receptor-α (PPARA) cause peroxisome proliferation in preimplantation mouse embryos. Reproduction, 138(3), 493-505.
Scopus23 WoS21 Europe PMC192009 Tunc, O., Thompson, J., & Tremellen, K. (2009). Improvement in sperm DNA quality using an oral antioxidant therapy. Reproductive BioMedicine Online, 18(6), 761-768.
Scopus99 WoS67 Europe PMC602009 Mitchell, M., Cashman, K., Gardner, D., Thompson, J., & Lane, M. (2009). Disruption of Mitochondrial Malate-Aspartate Shuttle Activity in Mouse Blastocysts Impairs Viability and Fetal Growth. Biology of Reproduction, 80(2), 295-301.
Scopus67 WoS52 Europe PMC482009 Irving-Rodgers, H., Morris, S., Collett, R., Peura, T., Davy, M., Thompson, J., . . . Rodgers, R. (2009). Phenotypes of the ovarian follicular basal lamina predict developmental competence of oocytes. Human Reproduction, 24(4), 936-944.
Scopus35 WoS35 Europe PMC242009 Chin, P., Macpherson, A., Thompson, J., Lane, M., & Robertson, S. (2009). Stress response genes are suppressed in mouse preimplantation embryos by granulocyte-macrophage colony-stimulating factor (GM-CSF). Human Reproduction, 24(12), 2997-3009.
Scopus57 WoS47 Europe PMC432008 Stokes, Y., Clark, A., & Thompson, J. (2008). Mathematical modeling of glucose supply toward successful in vitro maturation of mammalian oocytes. Tissue Engineering. Part A. Tissue Engineering, 14(9 Sp. Iss.), 1539-1547.
Scopus12 WoS12 Europe PMC82008 Berg, D., Thompson, J., Peterson, A., & Asher, G. (2008). The temporal relationship between oocyte maturation and early fertilisation events in relation to the pre-ovulatory LH peak and preimplantation embryo development in red deer (Cervus elaphus).. Animal Reproduction Science, 105(3-4), 332-343.
Scopus7 WoS4 Europe PMC22008 Banwell, K., & Thompson, J. (2008). In vitro Maturation of Mammalian oocytes: outcomes and consequences. Seminars in Reproductive Medicine, 26(2), 162-174.
Scopus45 WoS38 Europe PMC222008 Gilchrist, R., Lane, M., & Thompson, J. (2008). Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality. Human Reproduction Update, 14(2), 159-177.
Scopus839 WoS660 Europe PMC5602008 Kimura, K., Iwata, H., & Thompson, J. (2008). The effect of glucosamine concentration on the development and sex ratio of bovine embryos. Animal Reproduction Science, 103(3-4), 228-238.
Scopus42 WoS39 Europe PMC252008 Wakefield, S., Lane, M., Schulz, S., Hebart, M., Thompson, J., & Mitchell, M. (2008). Maternal supply of omega 3 polyunsaturated fatty acids alter mechanisms involved in oocyte and early embryo development in the mouse. American Journal of Physiology-Endocrinology and Metabolism, 294(2), E425-E434.
Scopus139 WoS123 Europe PMC922008 Yeo, C., Gilchrist, R., Thompson, J., & Lane, M. (2008). Exogenous growth differentiation factor 9 in oocyte maturation media enhances subsequent embryo development and fetal viability in mice. Human Reproduction, 23(1), 67-73.
Scopus131 WoS119 Europe PMC1032008 Bakos, H., Thompson, J., Inglis, D., & Lane, M. (2008). Sperm DNA damage is associated with assisted reproductive technology pregnancy. International Journal of Andrology, 31(5), 518-526.
Scopus84 WoS77 Europe PMC592007 Harvey, A., Kind, K., & Thompson, J. (2007). Regulation of gene expression in bovine Blastocysts in response to oxygen and the iron chelator desferrioxamine. Biology of Reproduction, 77(1), 93-101.
Scopus34 WoS28 Europe PMC272007 Tonack, S., Kind, K., Thompson, J., Wobus, A., Fischer, B., & Santos, A. (2007). Dioxin affects glucose transport via the arylhydrocarbon receptor signal cascade in pluripotent embryonic carcinoma cells. Endocrinology, 148(12), 5902-5912.
Scopus30 WoS26 Europe PMC212007 Pringle, K., Kind, K., Thompson, J., & Roberts, C. (2007). Complex interactions between hypoxia inducible factors, insulin-like growth Factor-II and oxygen in early murine trophoblasts. Placenta, 28(11-12), 1147-1157.
Scopus35 WoS32 Europe PMC292007 Banwell, K., Lane, M., Russell, D., Kind, K., & Thompson, J. (2007). Oxygen concentration during mouse oocyte in vitro maturation affects embryo and fetal development. Human Reproduction, 22(10), 2768-2775.
Scopus85 WoS75 Europe PMC642007 Thompson, J., Lane, M., & Gilchrist, R. (2007). Metabolism of the bovine cumulus-oocyte complex and influence on subsequent developmental competence. Journal of Reproduction and Fertility, 64(1), 179-190.
Scopus85 Europe PMC542007 Tremellen, K., Miari, G., Froiland, D., & Thompson, J. (2007). A randomised control trial examining the effect of an antioxidant (Menevit) on pregnancy outcome during IVF-ICSI treatment. Australian & New Zealand Journal of Obstetrics & Gynaecology, 47(3), 216-221.
Scopus167 WoS117 Europe PMC952007 Dragovic, R., Ritter, L., Schulz, S., Amato, F., Thompson, J., Armstrong, D., & Gilchrist, R. (2007). Oocyte-secreted factor activation of SMAD 2/3 signaling enables initiation of mouse cumulus cell expansion. Biology of Reproduction, 76(5), 848-857.
Scopus135 WoS114 Europe PMC942007 Gutnisky, C., Dalvit, G., Pintos, L., Thompson, J., Beconi, M., & Cetica, P. (2007). Influence of hyaluronic acid synthesis and cumulus mucification on bovine oocyte in vitro maturation, fertilisation and embryo development. Reproduction Fertility and Development, 19(3), 488-497.
Scopus64 WoS64 Europe PMC472007 Thompson, J., Mitchell, M., & Kind, K. (2007). Embryo culture and long-term consequences. Reproduction Fertility and Development, 19(1), 43-52.
Scopus64 WoS55 Europe PMC422007 Harvey, A., Navarrete Santos, A., Kirstein, M., Kind, K., Fischer, B., & Thompson, J. (2007). Differential expression of oxygen-regulated genes in bovine blastocysts. Molecular Reproduction and Development, 74(3), 290-299.
Scopus38 WoS34 Europe PMC272007 Gilchrist, R., & Thompson, J. (2007). Oocyte maturation: Emerging concepts and technologies to improve developmental potential in vitro. Theriogenology, 67(1), 6-15.
Scopus288 WoS248 Europe PMC1872007 Thompson, J. (2007). Culture without the petri-dish. Theriogenology, 67(1), 16-20.
Scopus24 WoS16 Europe PMC102006 Kelley, R., Kind, K., Lane, M., Robker, R., Thompson, J., & Edwards, L. (2006). Recombinant human follicle-stimulating hormone alters maternal ovarian hormone concentrations and the uterus and perturbs fetal development in mice. American Journal of Physiology-Endocrinology and Metabolism, 291(4), E761-E770.
Scopus32 WoS24 Europe PMC172006 Hussein, T., Thompson, J., & Gilchrist, R. (2006). Oocyte-secreted factors enhance oocyte developmental competence. Developmental Biology, 296(2), 514-521.
Scopus309 WoS271 Europe PMC2202006 Clark, A., Stokes, Y., Lane, M., & Thompson, J. (2006). Mathematical modelling of oxygen concentration in bovine and murine cumulus-oocyte complexes. Reproduction, 131(6), 999-1006.
Scopus60 WoS49 Europe PMC332006 McDowall, M., Mitchell, M., Cetica, P., Dalvit, G., Pantaleon, M., Lane, M., . . . Thompson, J. (2006). Glucosamine supplementation during in vitro maturation inhibits subsequent embryo development: Possible role of the hexosamine pathway as a regulator of developmental competence.. Biology of Reproduction, 74(5), 881-888.
Scopus42 WoS40 Europe PMC352006 Thompson, J. (2006). The impact of nutrition of the cumulus oocyte complex and embryo on subsequent development in ruminants. Journal of Reproduction and Development, 52(1), 169-175.
Scopus33 WoS28 Europe PMC242006 Zander, D., Thompson, J., & Lane, M. (2006). Perturbations in mouse embryo development and viability caused by ammonium are more severe after exposure at the cleavage stages. Biology of Reproduction, 74(2), 288-294.
Scopus99 WoS87 Europe PMC792006 Inglis, D., Lane, M., Roberts, C., Kelley, R., Edwards, L., Thompson, J., & Kind, K. (2006). Effect of culturing mouse embryos under different oxygen concentrations on subsequent fetal and placental development. Journal of Physiology-London, 572(1), 87-96.
Scopus76 WoS68 Europe PMC612006 Thompson, J., & Lane, M. (2006). The difference in pregnancy rates between elective single embryo transfer (SET) compared to double embryo transfer is dependent on the implantation rates of embryos being transferred. Using mathematical modeling to determine when SET becomes a viable option.. Human Reproduction, 21(8), 2195.
2006 Hussein, T., Gilchrist, R., & Thompson, J. (2006). Oocyte-secreted factors directly affect oocyte developmental competence during in vitro maturation of the bovine cumulus-oocyte complex. Reproduction Fertility and Development, 18(2), 271.
2006 Thompson, J. (2006). Implantation and Early Development. Human Fertility, 9(3), 197.
2005 McDowall, M., Gilchrist, R., & Thompson, J. (2005). Glucosamine supplementation during in vitro maturation leads to perturbed developmental capacity of bovine cumulus oocyte complexes. Reproduction Fertility and Development, 17(2), 300-301.
2005 Thompson, J. (2005). A mixed bag: A perspective on the regulation of IVF in Australia. Human Fertility, 8(2), 69-70.
Scopus2 Europe PMC22005 Hussein, T., Froiland, D., Amato, F., Thompson, J., & Gilchrist, R. (2005). Oocytes prevent cumulus cell apoptosis by maintaining a morphogenic paracrine gradient of bone morphogenetic proteins. Journal of Cell Science, 118(22), 5257-5268.
Scopus289 WoS259 Europe PMC2202005 Edwards, L., Kind, K., Armstrong, D., & Thompson, J. (2005). Effects of recombinant human follicle-stimulating hormone on embryo development in mice. American Journal of Physiology-Endocrinology and Metabolism, 288(5), E845-E851.
Scopus37 WoS29 Europe PMC202005 McDowall, M., Gilchrist, R., & Thompson, J. (2005). Effect of hexoses and gonadotrophin supplementation on bovine oocyte nuclear maturation during in vitro maturation in a synthetic follicle fluid medium. Reproduction Fertility and Development, 17(4), 407-415.
Scopus43 WoS43 Europe PMC322004 Kind, K., Collett, R., Harvey, A., & Thompson, J. (2004). Oxygen-regulated expression of GLUT-1, GLUT-3, and VEGF in the mouse blastocyst. Molecular Reproduction and Development, 70(1), 37-44.
Scopus78 WoS72 Europe PMC532004 Thomas, R., Thompson, J., Armstrong, D., & Gilchrist, R. (2004). Effect of specific phosphodiesterase isoenzyne inhibitors during in vitro maturation of bovine oocytes on meiotic and developmental capacity. Biology of Reproduction, 71(4), 1142-1149.
Scopus111 WoS98 Europe PMC812004 Harvey, A., Kind, K., Pantaleon, M., Armstrong, D., & Thompson, J. (2004). Oxygen-regulated gene expression in bovine blastocysts. Biology of Reproduction, 71(4), 1108-1119.
Scopus151 WoS138 Europe PMC1122004 McDowall, M., Gilchrist, R., & Thompson, J. (2004). Cumulus expansion and glucose utilisation by bovine cumulus-oocyte complexes during in vitro maturation: the influence of glucosamine and follicle-stimulating hormone. Reproduction, 128(3), 313-319.
Scopus103 WoS96 Europe PMC752004 Harvey, A., Kind, K., & Thompson, J. (2004). Effect of the oxidative phosphorylation uncoupler 2,4-dinitrophenol on hypoxia-inducible factor-regulated gene expression in bovine blastocysts. Reproduction Fertility and Development, 16(7), 665-673.
Scopus13 WoS12 Europe PMC102003 McDowall, M., Gilchrist, R., & Thompson, J. (2003). Effects of in-vivo and in-vitro environments on the metabolism of the cumulus-oocyte complex and its influence on oocyte developmental capacity. Human Reproduction Update, 9(1), 35-48.
Scopus332 WoS304 Europe PMC2162003 McDowall, M., Cetica, P., Beconi, M., Kind, K., Gilchrist, R., & Thompson, J. (2003). Influence of oocyte-secreted factors and culture duration on the metabolic activity of bovine cumulus cell complexes. Reproduction, 126(1), 27-34.
Scopus110 WoS96 Europe PMC792002 Berg, D., Pugh, P., Thompson, J., & Asher, G. (2002). Development of in vitro embryo production systems for red deer (Cervus elaphus) - Part 3. In vitro fertilisation using sheep serum as a capacitating agent and the subsequent birth of calves. Animal Reproduction Science, 70(1-2), 85-98.
Scopus25 WoS20 Europe PMC132002 Berg, D., Thompson, J., & Asher, G. (2002). Development of in vitro embryo production systems for red deer (Cervus elaphus) - Part 2. The timing of in vitro nuclear ooctye maturation. Animal Reproduction Science, 70(1-2), 77-84.
Scopus19 WoS17 Europe PMC112002 Berg, D., Thompson, J., & Asher, G. (2002). Development of in vitro embryo production systems for red deer (Cervus elaphus) - Part 1. Effect of epithelial oviductal monolayers and heparin on in vitro sperm motility and penetration of in vitro matured oocytes. Animal Reproduction Science, 70(1-2), 65-76.
Scopus18 WoS20 Europe PMC132002 De Matos, D., Gasparrini, B., Pasqualini, S., & Thompson, J. (2002). Effect of glutathione synthesis stimulation during in vitro maturation of ovine oocytes on embryo development and intracellular peroxide content. Theriogenology, 57(5), 1443-1451.
Scopus175 WoS159 Europe PMC972002 Thompson, J., Kind, K., Roberts, C., Robertson, S., & Robinson, J. (2002). Epigenetic risks related to assisted reproductive technologies - Short- and long-term consequences for the health of children conceived through assisted reproduction technology: more reason for caution?. Human Reproduction, 17(11), 2783-2786.
Scopus95 WoS85 Europe PMC542002 Harvey, A., Kind, K., & Thompson, J. (2002). REDOX regulation of early embryo development. Reproduction, 123(4), 479-486.
Scopus293 WoS259 Europe PMC2052002 Stojkovic, M., Kolle, S., Peinl, S., Stojkovic, P., Zakhartchenko, V., Thompson, J., . . . Wolf, E. (2002). Effects of high concentrations of hyaluronan in culture medium on development and survival rates of fresh and frozen-thawed bovine embryos produced in vitro. Reproduction, 124(1), 141-153.
Scopus91 WoS74 Europe PMC522002 Rieger, D., McGowan, L., Cox, S., Pugh, P., & Thompson, J. (2002). Effect of 2,4-dinitrophenol on the energy metabolism of cattle embryos produced by in vitro fertilization and culture. Reproduction Fertility and Development, 14(6), 339-343.
Scopus21 WoS22 Europe PMC162001 Whiteside, E., Kan, M., Jackson, M., Thompson, J., McNaughton, C., Herington, A., & Harvey, M. (2001). Urokinase-type plasminogen activator (uPA) and matrix metalloproteinase-9 (MMP-9) expression and activity during early embryo development in the cow. Anatomy and Embryology, 204(6), 477-483.
Scopus10 WoS9 Europe PMC72001 Machaty, Z., Thompson, J., Abeydeera, L., Day, B., & Prather, R. (2001). Inhibitors of mitochondrial ATP production at the time of compaction improve development of in vitro produced porcine embryos. Molecular Reproduction and Development, 58(1), 39-44.
Scopus42 WoS42 Europe PMC292000 Thompson, J., & Peterson, A. (2000). Bovine embryo culture in vitro: new developments and post-transfer consequences. Human Reproduction, 15(Suppl 5), 59-67.
WoS49 Europe PMC35 -
Book Chapters
Year Citation 2014 Robertson, S., & Thompson, J. (2014). Growth factors and cytokines in embryo development. In P. Quinn (Ed.), Culture Media, Solutions, and Systems in Human ART, 2014 (1 ed., pp. 112-131). United Kingdom: Cambridge University Press.
DOI Scopus22013 Thompson, J., & Gilchrist, R. (2013). Improving oocyte maturation in vitro. In Trounson, A, R. Gosden, & U. Eichenlaub-Ritter (Eds.), Biology and pathology of the oocyte: Role in fertility, medicine, and nuclear reprogramming (2 ed., pp. 212-223). United Kingdom: Cambridge University Press.
DOI Scopus52013 Thompson, J., Mottershead, D., & Gilchrist, R. (2013). Oocyte-secreted factors in domestic animals. In R. Krisher (Ed.), Oocyte Physiology and Development in Domestic Animals (1 ed., pp. 55-70). United Kingdom: Wiley.
DOI2011 Gilchrist, R., Smitz, J., & Thompson, J. (2011). Current Status and Future Trends of the Clinical Practice of Human Oocyte In Vitro Maturation. In D. Gardner, B. Rizk, & T. Falcone (Eds.), Human Assisted Reproductive Technology: Future Trends in Laboratory and Clinical Practice (1 ed., pp. 186-198). United Kingdom: Cambridge University Press.
DOI Scopus122006 Thompson, J., Lane, M., & Robertson, S. (2006). Adaptive responses of early embryos to their microenvironment and consequences for post-implantation development. In Unknown Book (Vol. 573, pp. 58-69). Kluwer Academic / Plenum Publ.
Scopus7 WoS62000 Thompson, J., Peterson, A., & McMillan, W. (2000). Bovine embryo production in vitro: New developments and post-transfer consequences. In R. Roberts, R. Yanagimachi, T. Kariya, & K. Hashizume (Eds.), Cloned animal and placentation (pp. 18-22). Tokyo, Japan: Yokendo Ltd. -
Conference Papers
Year Citation 2011 Chin, P. Y., Thompson, J. G., & Robertson, S. A. (2011). Maternal Interleukin-10 Deficiency Increases Sensitivity to Adverse Programming Effects of a Low Dose LPS Insult in the Pre-Implantation Period.. In BIOLOGY OF REPRODUCTION Vol. 85 (pp. 2 pages). Portland, OR: SOC STUDY REPRODUCTION. 2011 Russell, D. L., Matson, L. N., Dunning, K. R., Thompson, J. G., Robker, R. L., & Gilchrist, R. B. (2011). Patterning the Response to Oocyte Signals in Ovarian Follicle Morphogenesis.. In BIOLOGY OF REPRODUCTION Vol. 85 (pp. 2 pages). Portland, OR: SOC STUDY REPRODUCTION. 2011 Frank, L. A., Sutton-McDowall, M. L., Russell, D. L., Gilchrist, R. B., & Thompson, J. G. (2011). Proteomic Analysis of Beta-O-Linked Glycosylated Proteins Extracted from Glucosamine-Treated Mouse Cumulus-Oocyte Complexes Reveals HSP90 Glycosylation as a Potential Regulator of Oocyte Competence. In BIOLOGY OF REPRODUCTION Vol. 85 (pp. 2 pages). Portland, OR: SOC STUDY REPRODUCTION.
WoS12010 Sutton-McDowall, M. L., Gilchrist, R. B., & Thompson, J. G. (2010). MODULATION OF PORCINE NUCLEAR MATURATION STATUS USING A SPECIFIC PHOSPHODIESTERASE INHIBITOR. In REPRODUCTION FERTILITY AND DEVELOPMENT Vol. 22 (pp. 334-335). CSIRO PUBLISHING.
DOI2010 Gilchrist, R. B., Albuz, F. K., & Thompson, J. G. (2010). A NEW APPROACH TO <i>IN VITRO</i> MATURATION (IVM) AND EMBRYO <i>IN VITRO</i> PRODUCTION: INDUCED IVM SUBSTANTIALLY IMPROVES EMBRYO YIELD AND PREGNANCY OUTCOMES. In REPRODUCTION FERTILITY AND DEVELOPMENT Vol. 22 (pp. 293). CSIRO PUBLISHING.
DOI2010 Chin, P. Y., Thompson, J. G., & Robertson, S. A. (2010). Programming embryo development with a pre-implantation inflammatory insult. In JOURNAL OF REPRODUCTIVE IMMUNOLOGY Vol. 86 (pp. 39). Palm Grove, AUSTRALIA: ELSEVIER IRELAND LTD.
DOI WoS12009 Lopes, A. S., Dalvit, G. C., Lane, M., & Thompson, J. G. (2009). THE PEAK OF OXYGEN CONSUMPTION AT THE TIME OF SPERM PENETRATION IS ASSOCIATED WITH AN INCREASE IN REACTIVE OXYGEN SPECIES PRODUCTION IN BOVINE ZYGOTES. In REPRODUCTION FERTILITY AND DEVELOPMENT Vol. 21 (pp. 159). CSIRO PUBLISHING.
DOI2007 Pringle, K. G., Kind, K. L., Thompson, J. G., & Roberts, C. T. (2007). Oxygen and IGF-II interact in early murine trophoblasts. In PLACENTA Vol. 28 (pp. A15). Kingston, CANADA: W B SAUNDERS CO LTD.
WoS12007 Thompson, J., & Vajta, G. (2007). Foreword. In Theriogenology Vol. 67 (pp. 1). Elsevier Science Inc.
DOI2005 Hussein, T., Froiland, D., Thompson, J., & Gilchrist, R. (2005). Oocytes prevent bovine cumulus cell apoptosis by maintaining a morphogenic paracrine gradient of bone morphogenetic proteins. In Reproduction Fertility and Development Vol. 17(Suppl) (pp. 91). C S I R O Publishing.
DOI2005 Hussein, T., Froiland, D., Thompson, J., & Gilchrist, R. (2005). Oocyte-secreted factors prevent bovine cumulus apoptosis: paracrine regulation by bone morphogenetic proteins. In http://abstracts.co.allenpress.com/pweb/ssr2005/document/?ID=48049 (pp. 98-99). on line: Allen Press Inc. 2005 Camp-Dotlic, E., Froiland, D., Kind, K., Irving-Rodgers, H., Thompson, J., & Russell, D. (2005). Murine HIF-1a localisation by immunohistochemistry in a mouse reproductive tissue. In Reproduction Fertility and Development Vol. 17 (pp. 129). C S I R O Publishing.
DOI2005 Banwell, K., Lane, M., Russell, D., Kind, K., & Thompson, J. (2005). Oxygen concentration during in vitro maturation of murine oocytes affects blastocyst cell lineage. In Reproduction Fertility and Development Vol. 17 (pp. 91). C S I R O Publishing.
DOI2004 Hussein, T., Froiland, D., Thompson, J., & Gilchrist, R. (2004). Oocyte-secreted factor(s) regulate apoptosis of bovine cumulus cells. In Reproduction Fertility and Development Vol. 16 (suppl) (pp. 252). C S I R O Publishing.
DOI2004 McDowall, M., Gilchrist, R., & Thompson, J. (2004). Regulation of bovine oocyte meiotic and developmental capacity by glucose and glucosamine. In Reproduction Fertility and Development Vol. 16 (suppl) (pp. 204). C S I R O Publishing.
DOI2004 McDowall, M., Gilchrist, R., & Thompson, J. (2004). The effects of glucose and glucosamine on cumulus expansion and nuclear maturation of bovine cumulus-oocyte complexes. In Reproduction Fertility and Development Vol. 16 (pp. 283). C S I R O Publishing.
DOI2003 Thompson, J. (2003). 'Comets' in the andrology laboratory. In South Australian Council on Reproductive Technology Quarterly Bulletin Vol. 23 (pp. 1-2). Department of Health. 2003 Thompson, J. (2003). The risk of getting it wrong. In South Australian Council on Reproductive Technology Quarterly Bulletin Vol. 22 (pp. 1-2). Department of Health. 2001 Thompson, J. (2001). Newly emerging techniques for assisted reproductive technology (ART). In South Australian Council on Reproductive Technology Quarterly Bulletin Vol. 17 (pp. 1-2). Department of Health. 2001 Thompson, J. (2001). Level of protection of human embryos. In South Australian Council on Reproductive Technology Quarterly Bulletin Vol. 15 (pp. 6). Department of Health. -
Patents
Year Citation 2005 Thompson, J., Gilchrist, R., & Dragovic, R. (2005). WO/2007/009166, Modulation of granulosa cell apoptosis. Australia.
Major Grants
| 2016 |
“Development of a new embryo production medium storage system” JG Thompson, K Holata Commercial Accelerator Scheme (competitive), The University of Adelaide |
$38,800 |
| 2015 - 2017 |
“Inflammatory cytokines as causal agents in peri-conception programming of offspring health” SA Robertson, JG Thompson, H Brown NHMRC Project Grant ID 1079150 |
$585,276 |
| 2015 - 2019 |
“New insights into oocyte and embryo health” JG Thompson NHMRC Snr Research Fellowship ID 1077694 |
$750,810 |
| 2014 - 2020 |
“Centre of Excellence for Nanoscale Biophotonics” T Monro, J Piper, A Abell, N Packer, E Goldys, A Greentree, D Jin, B Gibson, M Hutchinson, J Thompson. ARC Centre of Excellence CE140100003 |
$39M |
| 2014 - 2016 |
“Integration of IVM technologies for hormone-free infertility treatment” RB Gilchrist, J Smitz, JG Thompson, D Mottershead NHMRC Development Grant ID 1076004 |
$552,000 |
| 2014 - 2016 |
“The obesity prone egg: causes, consequences, treatments” RL Robker, DR Russell, JG Thompson, J Carroll NHMRC Project ID1061819 |
$499,169 |
| 2014 - 2016 |
“EGF peptide signalling improves oocyte maturation and quality” RB Gilchrist, J Smitz, JG Thompson, D Mottershead NHMRC Project ID1062762 |
$567,562 |
| 2012 - 2013 |
“Improving fertility of high performance Holstein cows during early lactation.” JG Thompson, RL Robker, M Sutton-McDowall, R Yelland Gardiner Foundation INN-12-041 |
$60,000 |
| 2011-2013 |
“Nanosampling Sensors for Real-Time Embryo Monitoring” T Monro, J Thompson, R Gilchrist, A Abell ARC Linkage LP110200736 |
$640,000 |
|
2011 - 2013 |
“Oocyte secreted factors and cumulus cell function” JG Thompson, RB Gilchrist, M Sutton-McDowall, DK Gardner NHMRC Project ID1008137 |
$438,000 |
| 2010 - 2014 |
JG Thompson NHMRC Snr Research Fellowship ID627007 |
$694,000 |
| 2009 - 2010 |
“Improved Maturation of Oocytes for use in Animal Assisted Reproduction Technologies” RB Gilchrist, JG Thompson Commercial Accelerator Grant, Adelaide Research and Innovation |
$210,000 |
| 2007 - 2011 |
“Periconceptual Foundations for a Healthy Start to Life.” RJ Norman, RJ Rodgers, G Dekker, JG Thompson, SA Robertson, M Davies, M Lane. NHMRC Program ID453556 |
$10.4 million |
| 2005 - 2009 |
“The legacy of the peri-conception environment on subsequent development and health” JG Thompson NHMRC Snr Research Fellowship ID349446 |
$560,000 |
| 2008 - 2010 |
“Regulation of oocyte quality” RB Gilchrist, DR Russell, JG Thompson NHMRC Project Grant 519235 |
$555,375 |
| 2003 - 2007 |
“How do oocytes and embryos cope with adverse environments?” JG Thompson, LJ Edwards, RB Gilchrist, PL Kaye, KL Kind, M Pantaleon, CT Roberts, SA Robertson. National Institutes of Health (NIH) Project ID 1U01 HD044664-01 |
US$1.35million |
| 2005 - 2008 |
“Improving the efficiency of bovine oocyte maturation in vitro” RB Gilchrist, JG Thompson ARC – Linkage Project ID LP0562536 |
$473,445 |
| 2003 - 2006 |
“Reproductive Health and Disease in Women” RJ Norman, R Rodgers, DT Armstrong, JG Thompson, SA Robertson NHMRC Program ID 250306 |
$6.7M |
|
2002 - 2005 |
“GM-CSF and Human Embryo Development” SA Robertson, JG Thompson NHMRC Development ID 250388 |
$481,980.00 |
|
2001 - 2004 |
“Rational development of an improved method for oocyte maturation in cows” JG Thompson Sole Investigator ARC-SPIRT Project ID C00107702 |
$244,000 |
| 2001 - 2004 |
“Oxygen, oxidative phosphorylation and regulation of embryo development” JG Thompson New Investigator NHMRC Project Grant 157941 |
$205,000 |
Postgraduate and Undergraduate Teaching
Past and present Post-doctoral researchers
| 2014 | Dr Nelida Osario-Rodrigues (visiting from Colombia) |
| 2012 - present | Dr. Hannah Brown |
| 2008 - present | Dr. Melanie Sutton McDowall |
| 2010 – 2011 | Dr. Deanne Feil |
| 2003 – 2006 | Dr. Lisa Edwards |
| 2000 – 2008 | Dr. Karen Kind |
Past Ph.D. Students
| 1992 – 1998 - Debbie Berg |
Co-supervisor with Dr. G. Asher, enrolled in PhD through the University of Minnesota “Reproductive technologies in the Fallow deer, Dama dama” AgResearch Ruakura Research Centre, Hamilton, NEW ZEALAND Current Position: Research Scientist, AgResearch, Ruakura Research Centre, New Zealand. |
| 1998 – 2000 - Bianca Gasparrinni |
Co-supervisor with Prof. L. Zicarelli, University of Naples “The effect of OXPHOS inhibitors on bovine embryo development” (in Italian) AgResearch Ruakura Research Centre, Hamilton, NEW ZEALAND Current Position: Research Scientist at The University of Naples, Italy. |
| 2000 – 2004 - Alexandra Harvey |
Primary Supervisor “Oxygen regulated gene expression during bovine embryo development” The University of Adelaide, SA Awards: 2001:
2003:
Current Position: Post-Doctoral Researcher, Stem Cell Centre, The University of Melbourne, Melbourne, Victoria |
| 2001 – 2004 - Melanie Sutton-McDowell |
Primary Supervisor “Influence of media composition and metabolism of bovine cumulus-oocyte complexes on oocyte maturation in vitro” The University of Adelaide, SA Current position: Post-Doctoral fellow, Discipline of Obstetrics and Gynaecology, The University of Adelaide. Awards: 2002 - Finalist, North Western Adelaide Health Services Research Day Awards: 2006 SA “Tall Poppy” |
| 2003 – 2006 - Tamer Hussein |
Co-supervisor with Dr. Robert Gilchrist “Influence of oocyte-secreted factors on apoptosis of bovine cumulus cells” Awards: 2004 SRB Meat and Livestock Australia Young Scientist The University of Adelaide, SA Current Position: Clinical Embryologist, California USA |
| 2003 – 2007 - Michael Boden |
Co-supervisor with A/Prof. David Kennaway “Circadian Rhythms in the Reproductive Tract” The University of Adelaide, SA Awards: 2005:
Current Position: Post-doctoral Fellow, The University of Sydney, Sydney NSW. |
| 2004 – 2009 - Kelly Banwell |
Primary Supervisor “Oxygen concentration and oocyte developmental competence” The University of Adelaide, SA Current Position: Administration officer, The University of Adelaide, Adelaide, SA. |
| 2004 – 2012 - Cheryl Schelbach |
Primary supervisor "The effect of glucosamine on oocyte developmental competence and fertility" The University of Adelaide, SA Current Position: Teacher, Adelaide, SA. |
| 2005 – 2009 - Deirdre Zander |
Co-supervisor with Dr. Michelle Lane “Programming of embryos in culture” The University of Adelaide, SA Awards: 2006 – Queen Elizabeth Hospital Research Day – Higher Degree Award Current Position: Research Scientist, Repromed, Adelaide, SA |
| 2005 – 2009 - Deanne Feil |
Co-supervisor with Dr. Michelle Lane and Dr. Darryl Russell “Viability assays in human IVF” The University of Adelaide, SA Current Position: Unknown |
|
2005 – 2009 - Ozlem Tunc |
Co-supervisor with Dr. Kelton Tremellen “DNA damage in sperm” The University of Adelaide, SA Current Position: Unknown |
| 2005 – 2009 - Christine Yeo |
Co-supervisor with Dr. Michelle Lane “Assessment of developmental competence of oocytes’ The University of Adelaide, SA Current Position: Unknown |
| 2007 – 2011 - Firas Albuz |
Co-Supervisor with A/Prof. Robert Gilchrist “cAMP regulation of oocyte maturation and developmental competence” The University of Adelaide, SA Current Position: Clinical IVF Laboratory Head, Saudi Arabia. |
| 2006 – 2011 -Kimberley Tam |
Primary supervisor “Role of Hypoxia inducible factors during ovarian function” The University of Adelaide, SA Current Position: Researcher, Singapore. |
| 2008 – 2012 - Laura Frank |
Primary Supervisor “Hexosamine pathway activity and O-linked glycosylation as determinants of oocyte developmental competence” The University of Adelaide, SA Awards: 2011
Current Position: Medical Student and P/T Clinical embryologist, Fertility SA, Adelaide, SA. |
| 2010 – 2014 - Jacqueline Sudiman |
Co-Supervisor with A/Prof. Robert Gilchrist “Optimisation of oocyte in vitro maturation using oocyte secreted factors” The University of Adelaide, SA Current Position: Clinical embryologist, Indonesia |
| 2010 – 2014 - Dulama Richani |
Co-Supervisor with A/Prof. Robert Gilchrist “Impact of EGF-like peptides on oocyte developmental competence” The University of Adelaide, SA Current Position: Post-doctoral Research Fellow, The University of New South Wales, Sydney, NSW. |
| 2009 – 2014 – Peck Yin Chin |
Co-supervisor with A/Prof Sarah Robertson “Inflammatory cytokine regulation of preimplantation embryo development in mice”. The University of Adelaide, SA Current Position: Post-doctoral researcher, The University of Adelaide, Adelaide, SA. |
Present Ph.D. Students
| 2011- Current – Ryan Rose |
Primary supervisor “Effect of natiuretic peptides during oocyte maturation” The University of Adelaide, SA |
|
2015- Current – Hanna McLennan |
Co-supervisor with Dr Melanie McDowall “Ion signalling mechanisms during bovine fertilisation” The University of Adelaide, SA |
| 2016- Current – Megan Lim |
Co-supervisor with Dr Hannah Brown Haemoglobin in ovarian tissues – regulation and functions The University of Adelaide, SA |
| 2016- Current – Avi Saini |
Primary supervisor with Drs Hannah Brown, Melanie McDowall and Ms Lesley Ritter Non-reproductive applications of the zona pellucida The University of Adelaide, SA |
Past BSc and B Health Sc (Hons) Students
| 1990 - Stephen Payne |
Primary Supervisor “The effect of antioxidants on the culture of 1-cell mouse embryos” The University of Waikato, NEW ZEALAND |
| 1996 - Anita Sherman |
Primary Supervisor “Protein determination of preimplantation bovine embryos” The University of Waikato, NEW ZEALAND |
| 2003 - Deanne Feil |
Co-supervisor with Dr Karen Kind “The effect of oxygen concentration during mouse development on development on the regulation of Hypoxia Inducible Factors and subsequent fetal outcomes” Awards: 2004 – Fertility Society of Australia, Young Scientist & ESHRE Exchange Lecture University of Adelaide, SA Awarded 1st Class |
| 2005 - Hassan Bakos |
Co-Supervisor with Dr. Michelle Lane “The role of sperm DNA damage in embryo development – clinical trial” University of Adelaide, SA Awarded 1st Class |
| 2006 - Johan Haris |
Co-Supervisor with Dr. Robert Gilchrist “How exogenous oocyte-secreted factors affect the bovine cumulus-oocyte complex” University of Adelaide, SA |
| 2006 - Firas Albuz – Masters Qualifying leading to a M.Sc. |
Co-Supervisor with Dr. Robert Gilchrist “AMPK as a novel regulator of oocyte maturation and developmental competence” University of Adelaide, SA |
| 2012 – Luisa Cavaiuolo |
Co-supervisor with Dr. Melanie Sutton McDowall “Role of O-linked glycosylation during the peri-conception period on reproductive outcomes” University of Adelaide, SA |
|
2012 - Siew Wong |
Co-supervisor with Dr. Melanie Sutton McDowall “Interaction between lipotoxicity and hyperglycemia on endoplasmic reticulum stress” University of Adelaide, SA Awarded 1st Class |
| 2015 – Megan Lim |
Primary supervisor “Determining the presence and function of haemoglobin in the pre-implantation mouse embryo” University of Adelaide, SA Awarded 1st Class |
| 2015 – Emma Tregoweth |
Co-supervisor with Dr. Hannah Brown “Investigating the incidence and impact of blastomere cellular metabolic heterogeneity” University of Adelaide, SA |
|
Past MSc/MmedSc/B Health Sci 1991 - Stephen Payne |
Primary Supervisor “The effect of antioxidants during mouse embryo development in vitro” University of Waikato, NEW ZEALAND |
Undergraduate Teaching Involvement
| 2000 – 2016 |
Department of Obstetrics and Gynaecology, University of Adelaide Adelaide, SA, Australia Lectures on “Reproductive Biology” and “Reproductive Technologies” (3rd year) (1 h each) Course: Human Health Science |
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2016 Principal Supervisor Non-reproductive uses of Zonae Pellucida Master of Philosophy (Medical Science) Master Full Time Avishkar Saini -
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2019 - 2020 Principal Supervisor Bovine in vitro embryo production (IVP): assessment of two new approaches to improve the efficiency of embryo production Master of Philosophy (Medical Science) Master Full Time Miss Madeline Batsiokis 2016 - 2020 Principal Supervisor The Role of Haemoglobin in Healthy Oocyte Development Doctor of Philosophy Doctorate Full Time Ms Megan Lim 2015 - 2020 Principal Supervisor Detecting In Vitro Signals from the Cumulus-Oocyte-Complex and Spermatozoon as Diagnostic Tools: An Examination of Specific Fluorophores and Functionalised Optical Fibres Doctor of Philosophy Doctorate Full Time Miss Hanna Julie McLennan 2012 - 2014 Co-Supervisor Epidermal Growth Factor-Like Peptide Signalling and Oocyte In Vitro Maturation Doctor of Philosophy Doctorate Full Time Ms Dulama Richani 2011 - 2017 Co-Supervisor Novel Functions of Natriuretic Peptides in Mammalian Cumulus-Oocyte Complexes Doctor of Philosophy Doctorate Part Time Mr Ryan David Rose 2010 - 2014 Co-Supervisor Optimisation of Oocyte In Vitro Maturation using Oocyte Secreted Factors Doctor of Philosophy Doctorate Full Time Dr Jaqueline Sudiman 2009 - 2012 Principal Supervisor The Role of the Hexosamine Biosynthesis Pathway and Beta-O-Linked Glycosylation in Determining Oocyte Developmental Competence Doctor of Philosophy Doctorate Full Time Ms Laura Frank 2009 - 2014 Co-Supervisor Cytokines and programming the pre-implantation embryo Doctor of Philosophy Doctorate Full Time Dr Loretta Chin 2008 - 2010 Co-Supervisor Induced IVM: A New Approach to Oocyte Maturation in vitro Doctor of Philosophy Doctorate Full Time Mr Firas Albuz 2008 - 2010 Co-Supervisor The Effect of Paternal Obesity on Sperm Function, Embryo Development and Subsequent Pregnancy Outcomes Doctor of Philosophy Doctorate Full Time Mr Hassan Bakos 2007 - 2010 Principal Supervisor The Role of Hypoxia Inducible Factors in Regulating Ovarian Function Doctor of Philosophy Doctorate Full Time Miss Kimberley Tam 2007 - 2010 Co-Supervisor Importance of Oocyte to Cumulus Bi-Directional Signalling on Oocyte and Subsequent Embryo and Foetal Development and Viability Doctor of Philosophy Doctorate Part Time Miss Christine Yeo 2007 - 2011 Co-Supervisor Investigation of the Role of Oxidative Stress in Male Infertility Doctor of Philosophy Doctorate Full Time Mrs Ozlem Tunc 2006 - 2010 Co-Supervisor The Impact of In-Vitro Stress of Pre-Implantation Embryo Development, Viability and Mitochondrial Homeostasis Doctor of Philosophy Doctorate Full Time APrf Deirdre Zander 2006 - 2009 Principal Supervisor Oxygen Concentration during Oocyte Maturation in the Mouse Doctor of Philosophy Doctorate Full Time Dr Kelly Banwell 2006 - 2010 Co-Supervisor Determination of Non-Invasive Viability Markers for Human Embryos in In Vitro Fertilization Doctor of Philosophy Doctorate Part Time Ms Deanne Kate Inglis 2006 - 2012 Principal Supervisor An Investigation into the Effect of Glucosamine on Reproductive Outcomes in the Mouse Doctor of Philosophy Doctorate Full Time Ms Cheryl Schelbach 2005 - 2006 Co-Supervisor Role of Oocyte-Secreted Factors in Prevention of Cumulus Cell Apoptosis and Enhancement of Oocyte Developmental Competence Doctor of Philosophy Doctorate Full Time Dr Tamer Hussein 2005 - 2009 Co-Supervisor Mathematical Modelling and Experimental Investigation of Nutrient Supply to the Mammalian Oocyte Doctor of Philosophy Doctorate Full Time Miss Alys Clark 2004 - 2008 Co-Supervisor The Role of Circadian Rhythms in Reproduction: Development and Fertility in the bmal1 Null Mouse Doctor of Philosophy Doctorate Full Time Dr Michael Boden 2002 - 2004 Principal Supervisor The Rational Development of Improved In Vitro Maturation of Bovine Oocytes Doctor of Philosophy Doctorate Full Time Dr Melanie McDowall 2000 - 2004 Principal Supervisor EXPRESSION OF HYPOXIA-INDUCIBLE FACTORS DURING BOVINE PREIMPLANTATION EMBRYO DEVELOPMENT Doctor of Philosophy Doctorate Full Time Ms Alexandra Harvey
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Committee Memberships
Date Role Committee Institution Country 2014 - ongoing Member Society for Reproductive Biology (Australasian) - - 2012 - 2015 Treasurer Society for Reproductive Biology (Australasian) - - 2000 - ongoing President International Embryo Transfer Society - - 2000 - 2002 Chair Scientists in Reproductive Medicine (Australian – associated with Fertility Society of Australia) - - 1999 - ongoing Vice-President International Embryo Transfer Society - - 1998 - 2002 Board Member International Embryo Transfer Society - - 1996 - 1999 Member Australian Association of Animal Artificial Breeders - - 1996 - 1999 Secretary Australian Society of Reproductive Biology - - 1992 - 1994 Chair Australasian Association of Animal Artificial Breeders - - -
Memberships
Date Role Membership Country 2014 - ongoing - Developmental Origins of Health and Adult Disease (DOHAD) - 2004 - ongoing - Society for the Study of Reproduction - 2003 - 2005 - Developmental Origins of Health and Adult Disease (DOHAD) - 2000 - 2008 - Alpha (Scientists in Reproductive Medicine) - 2000 - 2005 - Fertility Society of Australia - 2000 - 2005 - Scientists in Reproductive Medicine (sub group of the Fertility Society of Australia) - 1994 - ongoing - International Embryo Transfer Society - 1989 - 2002 - New Zealand Society for Animal Production - 1989 - 1992 - Society for the Study of Fertility - 1982 - ongoing - (Australian) Society for Reproductive Biology - -
Consulting/Advisories
Date Institution Department Organisation Type Country 1994 - ongoing Cook Medical LLC - Business and professional United States -
Editorial Boards
Date Role Editorial Board Name Institution Country 2013 - ongoing Member Human Reproduction (Associate Editor, IF= 4.63) - - 2013 - ongoing Member Biology of Reproduction (IF = 4.03) - - 2012 - ongoing Member Journal of Assisted Reproduction and Genetics (IF = 1.82) - - 2012 - ongoing Associate Editor Human Reproduction - - 2004 - ongoing Member Human Fertility – International Advisory Board (No IF) - - 2002 - 2008 Member Reproduction, Fertility and Development (IF = 2.80) - - 1997 - 2010 Member Reproduction (formally Journal of Reproduction and Fertility, IF = 2.97) - - 1996 - 2006 Member Animal Reproduction Science (IF = 1.74) - -
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