Prof Allan Bretag

Prof Allan Bretag

School of Pharmacy and Biomedical Science

College of Health

Available For Media Comment.

Welcome to Allan Bretag's homepage.

a HREF=http://www.unisa.edu.au/pharm_medsci/staff/stfxtra/ab_res.htmResearch Interests

Year Citation
2020 Takeuchi, F., Nakamura, H., Yonemoto, N., Komaki, H., Bretag, A. H., & Nonaka, I. (2020). Clinical practice with steroid therapy for Duchenne muscular dystrophy: An expert survey in Asia and Oceania. Brain and Development, 42(3), 277-288.
DOI Scopus8 WoS9 Europe PMC8
2019 Bretag, A. H. (2019). Neuromuscular disorders in Asia and Oceania: A history of the Asian and Oceanian myology center (AOMC). Neurology Asia, 24(1), 83-86.
2017 Bretag, A. H. (2017). The glass micropipette electrode: A history of its inventors and users to 1950. Journal of general physiology, 149(4), 417-430.
DOI
2016 Bretag, A. H. (2016). Hans Hermann Behr (1818-1904): Botanist, entomologist, anthropologist, humorist and dangerous?. Papers and proceedings of the Royal Society of Tasmania, 150(1), 23-30.
DOI
2015 Bretag, A. H. (2015). Myotonic diseases since Asmus Julius Thomas Thomsen (1815-1896) and Peter Emil Becker (1908-2000). Proceedings of the Royal Society of Victoria, 127(1), 59-65.
DOI
2011 Ma, L., Rychkov, G., Bykova, E., Zheng, J., & Bretag, A. (2011). Movement of hCIC-1 C-termini during common gating and limits on their cytoplasmic location. Biochemical Journal, 436(2), 415-428.
DOI Scopus26 WoS25 Europe PMC26
2010 Cederholm, J., Rychkov, G., Bagley, C., & Bretag, A. (2010). Inter-subunit communication and fast gate integrity are important for common gating in hCIC-1. International Journal of Biochemistry & Cell Biology, 42(7), 1182-1188.
DOI Scopus24 WoS23 Europe PMC23
2009 Ma, L., Rychkov, G., & Bretag, A. (2009). Functional study of cytoplasmic loops of human skeletal muscle chloride channel, hClC-1. International Journal of Biochemistry & Cell Biology, 41(6), 1402-1409.
DOI Scopus6 WoS5 Europe PMC5
2008 Ma, L., Rychkov, G., Hughes, B., & Bretag, A. (2008). Analysis of carboxyl tail function in the skeletal muscle Cl⁻ channel hClC-1. Biochemical Journal, 413 Part 1(1), 61-69.
DOI Scopus7 WoS5 Europe PMC6
2008 Bretag, A. H. (2008). Stem cell treatment of dystrophic dogs. Nature, 450(7173), E23.
DOI
2008 Ma, L., Fu, S. B., & Bretag, A. H. (2008). Structure and function of CLC chloride channels. International Journal of Genetics, 31(1), 36-41.
2007 Bretag, A. (2007). Too much hype, not enough hope: Are balanced reporting and proper controls too much to expect from therapeutic studies in animal models of neuromuscular diseases that presage clinical trials in humans?. Neuromuscular Disorders, 17(3), 203-205.
DOI Scopus4 Europe PMC3
2006 Wu, W., Rychkov, G., Hughes, B., & Bretag, A. (2006). Functional complementation of truncated human skeletal-muscle chloride channel (hCIC-1) using carboxyl tail fragments. Biochemical Journal, 395(1), 89-97.
DOI Scopus15 WoS15 Europe PMC15
2005 Duffield, M., Rychkov, G., Bretag, A., & Roberts, M. (2005). Zinc inhibits human CIC-1 muscle chloride channel by interacting with its common gating mechanism. Journal of Physiology-London, 568(1), 5-12.
DOI Scopus23 WoS20 Europe PMC17
2004 Simpson, B., Height, T., Rychkov, G., Nowak, K., Laing, N., Hughes, B., & Bretag, A. (2004). Characterization of three myotonia-associated mutations of the CLCN1 chloride channel gene via heterologous expression. Human Mutation, 731(2), 1-7.
DOI Europe PMC23
2003 Duffield, M., Rychkov, G., Bretag, A., & Roberts, M. (2003). Involvement of helices at the dimer interface in C1C-1 common gating. Journal of General Physiology, 121(2), 149-161.
DOI Scopus103 WoS94 Europe PMC84
2003 Bretag, A. H. (2003). A history of the glass micropipette electrode. AxoBits.
2001 Aromataris, E., Rychkov, G., Bennetts, B., Hughes, B., Bretag, A., & Roberts, M. (2001). Fast and slow gating of CLC-1: Differential effects of 2-(4-chlorophenoxy) propionic acid and dominant negative mutations. Molecular Pharmacology, 60(1), 200-208.
DOI Scopus28 WoS25 Europe PMC21
2001 Bennetts, B., Roberts, M., Bretag, A., & Rychkov, G. (2001). Temperature dependence of human muscle ClC-1 chloride channel. Journal of Physiology-London, 535(1), 83-93.
DOI Scopus48 WoS43
2001 Rychkov, G., Pusch, M., Roberts, M., & Bretag, A. (2001). Interaction of hydrophobic anions with the rat skeletal muscle chloride channel ClC-1: effects on permeation and gating. Journal of Physiology-London, 530(3), 379-393.
DOI Scopus33 WoS33 Europe PMC25
2001 Aromataris, E. C., Rychkov, G., Bennetts, B., Hughes, B. P., Bretag, A. H., & Roberts, M. (2001). Fast and slow gating of CLC-1. Molecular pharmacology.
1999 Aromataris, E., Astill, D., Rychkov, G., Bryant, S., Bretag, A., & Roberts, M. (1999). Modulation of the gating of CIC-1 by S-(--) 2-(4-chlorophenoxy) propionic acid. British Journal of Pharmacology, 126(6), 1375-1382.
DOI Scopus38 WoS36 Europe PMC29
1998 Rychkov, G., Pusch, M., Roberts, M., Jentsch, T., & Bretag, A. H. (1998). Permeation and block of the skeletal muscle chloride channel, ClC-1, by foreign anions. Journal of General Physiology, 111(5), 653-665.
DOI Scopus137 WoS132 Europe PMC108
1998 Hryciw, D. H., Rychkov, G. Y., Hughes, B. P., & Bretag, A. H. (1998). Relevance of the D13 region to the function of the skeletal muscle chloride channel, ClC-1. Journal of Biological Chemistry, 273(8), 4304-4307.
DOI Scopus31 WoS31 Europe PMC27
1998 Kubisch, C., Schmidt Rose, T., Fontaine, B., Bretag, A. H., & Jentsch, T. (1998). ClC-1 chloride channel mutations in myotonia congenita: variable penetrance of mutations shifting the voltage dependence. Human molecular genetics, 7(11), 1753-1760.
DOI
1997 Rychkov, G., Hughes, B. P., Bretag, A. H., Astill, D., Bennetts, B., & Roberts, M. (1997). pH-dependent interactions of Cd2+ and a carboxylate blocker with the rat ClC-1 chloride channel and its R304E mutant in the Sf-9 insect cell line. Journal of physiology, 501(2), 355-362.
DOI Scopus41 WoS38 Europe PMC34
1996 Astill, D. S. J., Rychkov, G., Clarke, J. D., Hughes, B. P., Roberts, M. L., & Bretag, A. H. (1996). Characteristics of skeletal muscle chloride channel ClC-1 and point mutant R304E expressed in Sf-9 insect cells. Biochimica et Biophysica Acta. Biomembranes, 1280(2), 178-186.
DOI Scopus35 WoS32 Europe PMC28
1996 Rychkov, G. Y., Pusch, M., Astill, D. S. J., Roberts, M. L., Jentsch, T. J., & Bretag, A. H. (1996). Concentration and pH dependence of skeletal muscle chloride channel ClC-1. Journal of Physiology, 497(2), 423-435.
DOI Scopus145 WoS138 Europe PMC120
1994 Humpage, A. R., Rositano, J., Bretag, A. H., Brown, R., Baker, P. D., Nicholson, B. C., & Steffensen, D. A. (1994). Paralytic shellfish poisons from australian cyanobacterial blooms. Australian Journal of Marine and Freshwater Research, 45(5), 761-771.
DOI Scopus134

Year Citation
2001 Rychkov, G., Aromataris, E. C., Duffield, M., Roberts, M., & Bretag, A. H. (2001). Some Ion Channel Diseases of Muscle and their Treatment. In AOMC 2001 Interim Meeting: Mitochondrial Myopathy and other Muscle Disorders.
2001 Rychkov, G., Wu, W., Woods, A. E., Bretag, A. H., & Hughes, B. P. (2001). Visualisation of Full Length and Truncated Skeletal Muscle Chloride Channel Protein in SF9 Insect Cells. In Proceedings of the Australian Society for Biochemistry and Molecular Biology.
2001 Wu, W., Rychkov, G., Woods, A. E., Bretag, A. H., & Hughes, B. P. (2001). Visualisation of Full Length and Truncated CIC-1 Expressed in Sf9 Insect Cells. In 26th Lorne Protein Conference 2001.
2001 Rychkov, G., Aromataris, E. C., Duffield, M., Roberts, M., & Bretag, A. H. (2001). Permeation and Gating in Muscle-Type CLC Chloride Channels. In Molecular Physiology of Chloride Channels: From Melocule to Disease.
2000 Aromataris, E. C., Rychkov, G., Bennetts, B., Bretag, A. H., & Roberts, M. (2000). CI- dependence of gating of myotonic mutants of the CIC-1 chloride channel. In Proceedings of the Australian Physiological and Pharmacological Society.
2000 Davis, B., Secker, G. A., Hughes, B. P., & Bretag, A. H. (2000). bacterial expression of the amino- and carboxyl termini of CIC-1, the skeletal muscle chloride channel.. In 25th Annual Lorne Conference on Protein Structure and Function.
2000 Davis, B., Rychkov, G., Hughes, B. P., & Bretag, A. H. (2000). Importance of the carboxyl tail of the CIC-1 chloride channel. In proceedings of the Australian Physiological and Pharmacological Society.
2000 Bennetts, B., Roberts, M., Bretag, A. H., & Rychkov, G. (2000). Temperature dependence of CLC-1 chloride channel ating relaxations. In Proceedings of the Australian Physiological and Pharmacological Society.
1998 Rychkov, G., Roberts, M., & Bretag, A. H. (1998). Modulation of gating of the sekeletal muscle chloride channel, ClC-1, by OH- and by hydrophobic anions acting from the cytoplasmic side of the channel: implications for myotonic "warm-up". In Muselce and nerve supplement 7/1998 (IX International Congress on Neuromusclar Diseases. New York: John Wiley and Sons.
1998 Hryciw, D., Rychkov, G., Hughes, B. P., & Bretag, A. H. (1998). Investigation of the function of the carboxyl terminus of the skeletal muscle chloride channel, ClC-1.. In Muscle and Nerve Supplement 7/1998 (IX International Congress on Neuromuscular Diseases). New York: John Wiley & Sons.
1998 Bretag, A. H. (1998). Glass micropipette electrodes: their development and contribution to neuromuscular science. In Muscle and Nerve. New York: Wiley.
1998 Aromataris, E. C., Rychkov, G., Hughes, B. P., Bretag, A. H., & Roberts, M. (1998). S-(-)CPP Modulates the chloride affinity of the gating site of rClC-1. In Muscle and nerve supplement 7/1998 (IX International Congress on Neuromusclar Diseases). New York: John Wiley & Sons.
1997 Woods, A. E., Hughes, B. P., Bretag, A. H., & Hryciw, D. (1997). Immunolocalisation of the chloride channel ClC-1 in SF9 cells. In Proceedings of the Australian Physiological and Pharmacological Society.
1997 Rychkov, G., Hughes, B. P., Bretag, A. H., & Hryciw, D. (1997). Relevance of the Conserved Domain D13 to the function of the skeletal muscle chloride channel, ClC-1. In Twenty-third Annual Lorne Conference on Protein Structure and Function. Australia.
1997 Rychkov, G., Hughes, B. P., Bretag, A. H., Aromataris, E. C., & Roberts, M. (1997). 2-(4-chlorophenoxy)propionate alters channel gating and current kinetics of rClC-1. In Proceedings of the Australian Physiological and Pharmacological Society.
1997 Rychkov, G., Hughes, B. P., Bretag, A. H., & Hryciw, D. (1997). Effects of carboxyl terminus mutations in the skeletal muscle chloride channel, ClC-1. In Proceedings of the Australian Physiological and Pharmacological Society.
1997 Woods, A. E., Hughes, B. P., Bretag, A. H., & Hryciw, D. (1997). Visualisation of the skeletal muscle chloride channel in SF9 cells. In Proceedings of the Australian Society for Medical Research.
1997 Rychkov, G., Hughes, B. P., Bretag, A. H., & Hryciw, D. (1997). Mutagenesis studies of the C-terminus of the skeletal muscle chloride channel, ClC expressed in SF9 insect cells. In Proceedings of the Australian Society for Medical Research.

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