| 2025 |
Manning, J. A., Jesudason, S., Moretti, P. A. B., Pitson, S. M., Chou, A. S. Y., Shabbar, M., . . . Kumar, S. (2025). Nedd4-2 ablation in kidney improves glycaemic control in diabetic mice. Cell Death and Disease, 16(496), 1-23.
DOI Scopus1 WoS1 Europe PMC1 |
| 2023 |
Lazniewska, J., Li, K. L., Johnson, I. R. D., Sorvina, A., Logan, J. M., Martini, C., . . . Brooks, D. A. (2023). Dynamic interplay between sortilin and syndecan-1 contributes to prostate cancer progression. Scientific reports, 13(1, article no. 13489), 1-18.
DOI Scopus13 WoS12 Europe PMC10 |
| 2022 |
Pitman, M. R., Lewis, A. C., Davies, L. T., Moretti, P. A. B., Anderson, D., Creek, D. J., . . . Pitson, S. M. (2022). The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism. Scientific Reports, 12(1), 454-1-454-12.
DOI Scopus15 WoS13 Europe PMC12 |
| 2022 |
Tvorogov, D., Thompson-Peach, C. A. L., Foßelteder, J., Dottore, M., Stomski, F., Onnesha, S. A., . . . Lopez, A. F. (2022). Targeting human CALR-mutated MPN progenitors with a neoepitope-directed monoclonal antibody. EMBO Reports, 23(4), e52904-1-e52904-12.
DOI Scopus22 WoS22 Europe PMC21 |
| 2022 |
Lewis, A. C., Pope, V. S., Tea, M. N., Li, M., Nwosu, G. O., Nguyen, T. M., . . . Pitson, S. M. (2022). Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia.. Blood, 139(26), 3737-3751.
DOI Scopus37 WoS32 Europe PMC35 |
| 2020 |
Boyle, S. T., Poltavets, V., Kular, J., Pyne, N. T., Sandow, J. J., Lewis, A. C., . . . Samuel, M. S. (2020). Publisher Correction: ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism.. Nat Cell Biol, 22(7), 908.
DOI Scopus5 WoS4 Europe PMC6 |
| 2019 |
Powell, J. A., Pitman, M. R., Zebol, J. R., Moretti, P. A., Neubauer, H. A., Davies, L. T., . . . Pitson, S. M. (2019). Kelch-like protein 5-mediated ubiquitination of lysine 183 promotes proteasomal degradation of sphingosine kinase 1. The Biochemical Journal, 476(21), 3211-3226.
DOI Scopus14 WoS14 Europe PMC12 |
| 2019 |
Neubauer, H. A., Tea, M. N., Zebol, J. R., Gliddon, B. L., Stefanidis, C., Moretti, P. A. B., . . . Pitson, S. M. (2019). Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma. Oncogene, 38(8), 1151-1165.
DOI Scopus26 WoS24 Europe PMC18 |
| 2017 |
Powell, J., Lewis, A., Zhu, W., Toubia, J., Pitman, M., Wallington-Beddoe, C., . . . Pitson, S. (2017). Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia.. Blood, 129(6), 771-782.
DOI Scopus86 WoS80 Europe PMC74 |
| 2017 |
Zhu, W., Gliddon, B., Jarman, K., Moretti, P., Tin, T., Parise, L., . . . Pitson, S. (2017). CIB1 contributes to oncogenic signalling by Ras via modulating the subcellular localisation of sphingosine kinase 1. Oncogene, 36(18), 2619-2627.
DOI Scopus29 WoS27 Europe PMC19 |
| 2017 |
Wallington-Beddoe, C., Bennett, M., Vandyke, K., Davies, L., Zebol, J., Moretti, P., . . . Pitson, S. (2017). Sphingosine kinase 2 inhibition synergises with bortezomib to target myeloma by enhancing endoplasmic reticulum stress. Oncotarget, 8(27), 43602-43616.
DOI Scopus42 WoS40 Europe PMC36 |
| 2017 |
Zhu, W., Jarman, K., Lokman, N., Neubauer, H., Davies, L., Gliddon, B., . . . Pitson, S. (2017). CIB2 negatively regulates oncogenic signaling in ovarian cancer via sphingosine kinase 1. Cancer Research, 77(18), 4823-4834.
DOI Scopus30 WoS26 Europe PMC26 |
| 2016 |
Neubauer, H. A., Pham, D. H., Zebol, J. R., Moretti, P. A. B., Peterson, A. L., Leclercq, T. M., . . . Pitson, S. M. (2016). An oncogenic role for sphingosine kinase 2. Oncotarget, 7(40), 64886-64899.
DOI Scopus54 WoS50 Europe PMC52 |
| 2015 |
Pitman, M., Powell, J., Coolen, C., Moretti, P., Zebol, J., Pham, D., . . . Pitson, S. (2015). A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties. Oncotarget, 6(9), 7065-7083.
DOI Scopus65 WoS64 Europe PMC56 |
| 2015 |
Parham, K., Zebol, J., Tooley, K., Sun, W., Moldenhauer, L., Cockshell, M., . . . Bonder, C. (2015). Sphingosine 1-phosphate is a ligand for peroxisome proliferator-activated receptor-γ that regulates neoangiogenesis. The FASEB Journal, 29(9), 3638-3653.
DOI Scopus82 WoS77 Europe PMC70 |
| 2015 |
Kular, J., Scheer, K., Pyne, N., Allam, A., Pollard, A., Magenau, A., . . . Samuel, M. (2015). A negative regulatory mechanism involving 14-3-3ζ limits signaling downstream of ROCK to regulate tissue stiffness in epidermal homeostasis. Developmental Cell, 35(6), 759-774.
DOI Scopus30 WoS24 Europe PMC29 |
| 2014 |
Pham, D., Powell, J., Gliddon, B., Moretti, P., Tsykin, A., Van der Hoek, M., . . . Pitson, S. (2014). Enhanced expression of transferrin receptor 1 contributes to oncogenic signalling by sphingosine kinase 1. Oncogene, 33(48), 5559-5568.
DOI Scopus26 WoS25 Europe PMC23 |
| 2011 |
Barrett, J., Parham, K., Pippal, J., Cockshell, M., Moretti, P., Brice, S., . . . Bonder, C. (2011). Over-expression of sphingosine kinase-1 enhances a progenitor phenotype in human endothelial cells. Microcirculation, 18(7), 583-597.
DOI Scopus10 WoS10 Europe PMC9 |
| 2011 |
Pitman, M., Barr, R., Gliddon, B., Magarey, A., Moretti, P., & Pitson, S. (2011). A critical role for the protein phosphatase 2A B′α regulatory subunit in dephosphorylation of sphingosine kinase 1. International Journal of Biochemistry & Cell Biology, 43(3), 342-347.
DOI Scopus23 WoS18 Europe PMC20 |
| 2011 |
Leclercq, T., Moretti, P., & Pitson, S. (2011). Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis. Oncogene, 30(3), 372-378.
DOI Scopus47 WoS39 Europe PMC36 |
| 2011 |
Xia, P., Wang, L., Moretti, P. A. B., Albanese, N., Chai, F., Pitson, S. M., . . . Vadas, M. A. (2011). Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-α signaling. Journal of Biological Chemistry, 286(11), 9894.
DOI |
| 2011 |
Xia, P., Wang, L., Moretti, P. A. B., Albanese, N., Chai, F., Pitson, S. M., . . . Vadas, M. A. (2011). Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-α signaling (Journal of Biological Chemistry (2002) 227, (7996-8003)). Journal of Biological Chemistry, 286(49), 42785.
DOI |
| 2010 |
Jarman, K., Moretti, P., Zebol, J., & Pitson, S. (2010). Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1. Journal of Biological Chemistry, 285(1), 483-492.
DOI Scopus127 WoS115 Europe PMC106 |
| 2009 |
Zebol, J., Hewitt, N., Moretti, P., Lynn, H., Lake, J., Li, P., . . . Pitson, S. (2009). The CCT/TRiC chaperonin is required for maturation of sphingosine kinase 1. International Journal of Biochemistry & Cell Biology, 41(4), 822-827.
DOI Scopus18 WoS16 Europe PMC15 |
| 2008 |
Leclercq, T., Moretti, P., Vadas, M., & Pitson, S. (2008). Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity. Journal of Biological Chemistry, 283(15), 9606-9614.
DOI Scopus48 WoS46 Europe PMC45 |
| 2008 |
Pham, D., Moretti, P., Goodall, G., & Pitson, S. (2008). Attenuation of leakiness in doxycycline-inducible expression via incorporation of 3 ' AU-rich mRNA destabilizing elements. Biotechniques, 45(2), 155-162.
DOI Scopus20 WoS18 Europe PMC19 |
| 2008 |
Barr, R., Lynn, H., Moretti, P., Khew-Goodall, Y., & Pitson, S. (2008). Deactivation of Sphingosine Kinase 1 by Protein Phosphatase 2A. Journal of Biological Chemistry, 283(50), 34994-35002.
DOI Scopus51 WoS43 Europe PMC42 |
| 2008 |
Pham, D., Moretti, P., Goodall, G., & Pitson, S. (2008). Attenuation of leakiness in doxycycline-inducible expression via incorporation of 3' AU-rich mRNA destabilizing elements. BioTechniques: the journal of laboratory technology for bioresearch, 155(2), 45-162. |
| 2006 |
O'Halloran, C., Moretti, P., Hewitt, N., Bagley, C., Vadas, M., & Pitson, S. (2006). The calmodulin-binding site of sphingosine kinase and its role in agonist-dependent translocation of sphingosine kinase 1 to the plasma membrane. Journal of Biological Chemistry, 281(17), 11693-11701.
DOI Scopus66 WoS62 Europe PMC53 |
| 2005 |
Pitson, S., Xia, P., Leclercq, T., Moretti, P., Zebol, J., Lynn, H., . . . Vadas, M. (2005). Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling. Journal of Experimental Medicine, 201(1), 49-54.
DOI Scopus239 WoS229 Europe PMC214 |
| 2004 |
Roberts, J., Moretti, P., Darrow, A., Derian, C., Vadas, M., & Pitson, S. (2004). An assay for sphingosine kinase activity using biotinylated sphingosine and streptavidin-coated membranes. Analytical Biochemistry, 331(1), 122-129.
DOI Scopus37 WoS34 Europe PMC30 |
| 2003 |
Pitson, S., Moretti, P., Zebol, J., Lynn, H., Xia, P., Vadas, M., & Wattenberg, B. (2003). Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation. EMBO Journal, 22(20), 5491-5500.
DOI Scopus496 WoS476 Europe PMC428 |
| 2002 |
Pitson, S., Moretti, P., Zebol, J., Zareie, R., Derian, C., Darrow, A., . . . Wattenberg, B. (2002). The nucleotide-binding site of human sphingosine kinase 1. Journal of Biological Chemistry, 277(51), 49545-49553.
DOI Scopus98 WoS94 Europe PMC81 |
| 2002 |
Xia, P., Wang, L., Moretti, P., Albanese, N., Chai, F., Pitson, S., . . . Vadas, M. (2002). Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-a signaling. Journal of Biological Chemistry, 277(10), 7996-8003.
DOI Scopus282 WoS261 Europe PMC237 |
| 2001 |
Pitson, S., Moretti, P., Zebol, J., Vadas, M., D'Andrea, R., & Wattenberg, B. (2001). A point mutant of human sphingosine kinase 1 with increased catalytic activity. FEBS Letters, 509(2), 169-173.
DOI Scopus16 WoS16 Europe PMC15 |
| 2001 |
Moretti, P., Davidson, A., Baker, E., Lilley, B., Zon, L., & D'Andrea, R. (2001). Molecular cloning of a human Vent-like homeobox gene. Genomics, 76(01-Mar), 21-29.
DOI Scopus20 WoS19 Europe PMC20 |
| 2000 |
Xia, P., Gamble, J., Wang, L., Pitson, S., Moretti, P., Wattenberg, B., . . . Vadas, M. (2000). An oncogenic role of sphingosine kinase. Current Biology, 10(23), 1527-1530.
DOI Scopus364 WoS337 Europe PMC307 |
| 2000 |
Pitson, S., D'Andrea, R., Vandeleur, L., Moretti, P., Xia, P., Gamble, J., . . . Wattenberg, B. (2000). Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes. Biochemical Journal, 350(2), 429-441.
DOI Scopus166 WoS158 Europe PMC146 |
| 2000 |
Pitson, S., Moretti, P., Zebol, J., Xia, P., Gamble, J., Vadas, M., . . . Wattenberg, B. (2000). Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation. Journal of Biological Chemistry, 275(43), 33945-33950.
DOI Scopus173 WoS172 Europe PMC149 |
| 1997 |
Barry, S., Korpelainen, E., Sun, Q., Stomski, F., Moretti, P., Wakao, H., . . . Goodall, G. (1997). Roles of the N and C terminal domains of the interleukin-3 receptor alpha chain in receptor function.. Blood, 89(3), 842-852.
DOI Scopus54 WoS55 Europe PMC28 |
| 1994 |
Barry, S. C., Bagley, C. J., Phillips, J., Dottore, M., Cambareri, B., Moretti, P., . . . Lopez, A. F. (1994). Two contiguous residues in human interleukin-3, Asp 21 and Glu 22, selectively interact with the α- and β-chains of its receptor and participate in function. Journal of Biological Chemistry, 269(11), 8488-8492.
DOI Scopus76 WoS76 Europe PMC46 |
| 1994 |
Moretti, P., Simmons, P., Thomas, P., Haylock, D., Rathjen, P., Vadas, M., & D'Andrea, R. (1994). Identification of homeobox genes expressed in human haemopoietic progenitor cells. Gene, 144(2), 213-219.
DOI Scopus53 WoS51 Europe PMC40 |
| 1994 |
D'Andrea, R., Rayner, J., Moretti, P., Lopez, A., Goodall, G. J., Gonda, T. J., & Vadas, M. (1994). A mutation of the common receptor subunit for interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor, and IL-5 that leads to ligand independence and tumorigenicity. Blood, 83(10), 2802-2808.
DOI Scopus54 WoS57 Europe PMC27 |
| 1993 |
Lockett, T. J., Moretti, P. A. B., Lake, J. A., & Saint, R. (1993). Rough genes with deformed homeobox substitutions exhibit rough regulatory specificity during Drosophila eye development. Mechanisms of Development, 41(1), 57-68.
DOI Scopus6 WoS6 Europe PMC5 |
