Steve McInnes

Dr Steve McInnes

School of Mathematical Sciences

College of Science

Entrapment of therapeutic agents: The production of a wide variety of such composites has allowed for the combination of the high surface area and biocompatibility of pSi with the use of a multitude of polymerization techniques including the surface initiated ring opening polymerization of poly(L-lactide) and the free radical polymerization of vinylbenzylthymine. Work has also focused on the use of iCVD for the low temperature solvent free polymerization of thermo and pH responsive polymers. It is hoped that with further experimentation these inorganic/organic pSi/polymer hybrid materials will show promising drug delivery properties along with biocompatibility and biodegradability.,Direct attachment of therapeutic agents: The conjugation of biomolecules to the surface of pSi via the creation of a multitude of novel organic linker compounds has been performed in an attempt to control the release of these tailor made (organically synthesized) biomolecules. It is envisioned that with further tuning the future use of these new composite materials could lead to the development of cancer therapies with a more targeted delivery method that could help to minimize the toxic systemic effects of future cancer treatments (compared to conventional methods, such as chemotherapy).

Year Citation
2024 Oustadi, F., Imani, R., Nazarpak, M. H., Sharifi, A. M., & McInnes, S. J. P. (2024). Nanofiber/hydrogel composite scaffold incorporated by silicon nanoparticles for sustained delivery of osteogenic factor: in vitro study. International Journal Of Polymeric Materials And Polymeric Biomaterials, 73(3), 200-213.
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2024 Aghajanzadeh, M. S., Imani, R., Nazarpak, M. H., & McInnes, S. J. P. (2024). Augmented physical, mechanical, and cellular responsiveness of gelatin-aldehyde modified xanthan hydrogel through incorporation of silicon nanoparticles for bone tissue engineering. International Journal of Biological Macromolecules, 259(129231), 1-15.
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2022 Rabiei, M., Kashanian, S., Samavati, S. S., Derakhshankhah, H., Jamasb, S., & McInnes, S. J. P. (2022). Characteristics of SARS-CoV2 that may be useful for nanoparticle pulmonary drug delivery. Journal of Drug Targeting, 30(3), 233-243.
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2022 Sabzevari, A. G., Sabahi, H., Nikbakht, M., & McInnes, S. J. P. (2022). Development and characteristics of layered EGCG/Montmorillonite hybrid: an oral controlled-release formulation of EGCG. Journal of Drug Delivery Science and Technology, 76(article no. 103750), 1-8.
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2021 Aujla, T., Darby, J. R. T., Saini, B. S., Lock, M. C., Holman, S. L., Bradshaw, E. L., . . . Morrison, J. L. (2021). Impact of resveratrol-mediated increase in uterine artery blood flow on fetal haemodynamics, blood pressure and oxygenation in sheep. Experimental Physiology, 106(5), 1166-1180.
DOI Scopus9 WoS9 Europe PMC9
2021 Rabiei, M., Kashanian, S., Samavati, S. S., Derakhshankhah, H., Jamasb, S., & McInnes, S. J. P. (2021). Nanotechnology application in drug delivery to osteoarthritis (OA), rheumatoid arthritis (RA), and osteoporosis (OSP). Journal of Drug Delivery Science and Technology, 61(102011), 1-11.
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2021 Rabiei, M., Kashanian, S., Bahrami, G., Derakhshankhah, H., Barzegari, E., Samavati, S. S., & McInnes, S. J. P. (2021). Dissolving microneedle-assisted long-acting Liraglutide delivery to control type 2 diabetes and obesity. European Journal of Pharmaceutical Sciences, 167(106040), 1-9.
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2020 Rabiei, M., Kashanian, S., Samavati, S. S., Jamasb, S., & McInnes, S. J. P. (2020). Nanomaterial and advanced technologies in transdermal drug delivery. Journal of Drug Targeting, 28(4), 356-367.
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2019 Darby, J. R. T., Saini, B. S., Soo, J. Y., Lock, M. C., Holman, S. L., Bradshaw, E. L., . . . Morrison, J. L. (2019). Subcutaneous maternal resveratrol treatment increases uterine artery blood flow in the pregnant ewe and increases fetal but not cardiac growth. The journal of physiology, 597(20), 5063-5077.
DOI Scopus40 WoS39 Europe PMC34
2019 Rabiei, M., Kashanian, S., Samavati, S. S., Jamasb, S., & McInnes, S. J. P. (2019). Active targeting towards and inside the brain based on nanoparticles: a review. Current Pharmaceutical Biotechnology, 21(5), 374-383.
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2018 McInnes, S. J. P., Macdonald, T. J., Parkin, I. P., Nann, T., & Voelcker, N. H. (2018). Electrospun composites of polycaprolactone and porous silicon nanoparticles for the tunable delivery of small therapeutic molecules. Nanomaterials, 8(4, article no. 205), 1-12.
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2018 Bodiford, N. K., McInnes, S. J. P., Voelcker, N. H., & Coffer, J. L. (2018). Porous silicon-poly(ε-caprolactone) film composites: evaluation of drug release and degradation behavior. Biomedical microdevices, 20(3, article no. 71), 1-9.
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2018 Stead, S. O., McInnes, S. J. P., Kireta, S., Rose, P. D., Jesudason, S., Rojas-Canales, D., . . . Voelcker, N. H. (2018). Manipulating human dendritic cell phenotype and function with targeted porous silicon nanoparticles. Biomaterials, 155, 92-102.
DOI Scopus38 WoS33 Europe PMC26
2018 Stead, S., Kireta, S., McInnes, S., Kette, F., Sivanathan, K., Kim, J., . . . Coates, P. (2018). Murine and non-human primate dendritic cell targeting nanoparticles for in vivo generation of regulatory T-Cells. ACS Nano, 12(7), 6637-6647.
DOI Scopus53 WoS47 Europe PMC38
2017 Irani, Y. D., Klebe, S., McInnes, S. J. P., Jasieniak, M., Voelcker, N. H., & Williams, K. A. (2017). Oral mucosal epithelial cells grown on porous silicon membrane for transfer to the rat eye. Scientific Reports, 7(1), 10042-1-10042-11.
DOI Scopus11 WoS9 Europe PMC6
2017 Turner, C. T., Mcinnes, S. J. P., Melville, E., Cowin, A., & Voelcker, N. H. (2017). Delivery of flightless I neutralizing antibody from porous silicon nanoparticles improves wound healing in diabetic mice. Advanced healthcare materials, 6(2, article no. 1600707), 1-13.
DOI Scopus41 WoS40 Europe PMC29
2017 Kumeria, T., McInnes, S., Maher, S., & Santos, A. (2017). Porous silicon for drug delivery applications and theranostics: recent advances, critical review and perspectives. Expert Opinion on Drug Delivery, 14(12), 1407-1422.
DOI Scopus83 WoS66 Europe PMC32
2017 Turner, C. T., McInnes, S. J. P., Melville, E., Cowin, A. J., & Voelcker, N. H. (2017). Wound healing: delivery of flightless I neutralizing antibody from porous silicon nanoparticles improves wound healing in diabetic mice (Adv. Healthcare Mater. 2/2017). Advanced healthcare materials, 6(2), 1.
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2017 Sinha, S., Tong, W. Y., Williamson, N. H., McInnes, S. J. P., Puttick, S., Cifuentes Rius, A., . . . Voelcker, N. H. (2017). Novel Gd-loaded silicon nanohybrid: a potential epidermal growth factor receptor expressing cancer cell targeting magnetic resonance imaging contrast agent. ACS applied materials and interfaces, 9(49), 42601-42611.
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2016 Turner, C. T., McInnes, S. J. P., Melville, E., Voelcker, N. H., & Cowin, A. J. (2016). Delivery of flightless I neutralizing antibody from porous silicon nanoparticles improves healing in diabetic mice. Wound repair and regeneration, 24(6), 17-18.
2016 McInnes, S., Michl, T., Delalat, B., Al-Bataineh, S., Coad, B., Vasilev, K., . . . Voelcker, N. (2016). "Thunderstruck": plasma-polymer-coated porous silicon microparticles ss a controlled drug delivery system. ACS Applied Materials and Interfaces, 8(7), 4467-4476.
DOI Scopus30 WoS28 Europe PMC12
2016 Mcinnes, S., Turner, C., Cowin, A., & Voelcker, N. (2016). Loading and release of porous silicon nanoparticles with Flightless I neutralizing antibodies to aid wound healing. Frontiers in bioengineering and biotechnology, 4, 1.
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2016 Siavashani, A. Z., Nazarpak, M. H., Fayyazbakhsh, F., Toliyat, T., McInnes, S. J. P., & Solati Hashjin, M. (2016). Effect of amino-functionalization on insulin delivery and cell viability for two types of silica mesoporous structures. Journal of materials science, 51(24), 10897-10909.
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2016 Kashanian, S., Rostami, E., Harding, F. J., McInnes, S. J. P., Al Bataineh, S., & Voelcker, N. H. (2016). Controlled delivery of levothyroxine using porous silicon as a drug nanocontainer. Australian journal of chemistry, 69(2), 204-211.
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2016 Guinan, T. M., Kobus, H., Lu, Y., Sweetman, M., Mcinnes, S. J. P., Kirkbride, K. P., & Voelcker, N. H. (2016). Nanostructured silicon-based fingerprint dusting powders for enhanced visualization and detection by mass spectrometry. ChemPlusChem, 81(3), 258-261.
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2016 McInnes, S. J. P., Szili, E. J., Al Bataineh, S. A., Vasani, R. B., Xu, J., Alf, M. E., . . . Voelcker, N. H. (2016). Fabrication and characterization of a porous silicon drug delivery system with an initiated chemical vapor deposition temperature-responsive coating. Langmuir, 32(1), 301-308.
DOI Scopus49 Europe PMC23
2015 Sweetman, M. J., McInnes, S. J. P., Vasani, R. B., Guinan, T., Blencowe, A., & Voelcker, N. H. (2015). Rapid, metal-free hydrosilanisation chemistry for porous silicon surface modification. Chemical Communications, 51(53), 10640-10643.
DOI Scopus19 WoS19 Europe PMC9
2015 Turner, C. T., McInnes, S. J. P., & Cowin, A. J. (2015). Therapeutic antibodies for improved wound healing. Wound practice and research, 23(1), 16-24.
WoS4
2015 Chandrasekaran, S., McInnes, S. J. P., Macdonald, T. J., Nann, T., & Voelcker, N. H. (2015). Porous silicon nanoparticles as a nanophotocathode for photoelectrochemical water splitting. RSC Advances, 5(104), 85978-85982.
DOI
2015 Turner, C., McInnes, S., Voelcker, N., & Cowin, A. (2015). Therapeutic potential of inorganic nanoparticles for the delivery of monoclonal antibodies. Journal of Nanomaterials, 2015(309602), 309602-1-309602-11.
DOI Scopus27 WoS21
2015 McInnes, S., Turner, C., Al-Bataineh, S., Airaghi Leccardi, M., Irani, Y., Williams, K., . . . Voelcker, N. (2015). Surface engineering of porous silicon to optimise therapeutic antibody loading and release. Journal of Materials Chemistry B, 3(20), 4123-4133.
DOI Scopus31 WoS26 Europe PMC12
2015 Irani, Y. D., Tian, Y., Wang, M., Klebe, S., McInnes, S. J., Voelcker, N. H., . . . Williams, K. A. (2015). A novel pressed porous silicon-polycaprolactone composite as a dual-purpose implant for the delivery of cells and drugs to the eye. Experimental Eye Research, 139, 123-131.
DOI Scopus25 WoS23 Europe PMC13
2014 Hasanzadeh Kafshgari, M., Cavallaro, A. A., Delalat, B., Harding, F. J., McInnes, S. J. P., Makila, E., . . . Voelcker, N. (2014). Nitric oxide-releasing porous silicon nanoparticles. Nanoscale research letters, 9(article no. 333), 1-9.
DOI Scopus45 WoS42
2014 Jenie, A. S. N., Du, Z., McInnes, S. J. P., Ung, P., Graham, B., Plush, S. E., & Voelcker, N. (2014). Biomolecule detection in porous silicon based microcavities via europium luminescence enhancement. Journal of materials chemistry B, 2(44), 7694-7703.
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2012 McInnes, S. J. P., & Voelcker, N. H. (2012). Porous silicon-based nanostructured microparticles as degradable supports for solid-phase synthesis and release of oligonucleotides. Nanoscale research letters, 7(385), 1-10.
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2012 Holthausen, D., Vasani, R. B., McInnes, S. J. P., Ellis, A. V., & Voelcker, N. H. (2012). Polymerization-amplified optical DNA detection on porous silicon templates. ACS macro letters, 1(7), 919-921.
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2012 McInnes, S. J. P., Irani, Y., Williams, K. A., & Voelcker, N. H. (2012). Controlled drug delivery from composites of nanostructured porous silicon and poly(L-lactide). Nanomedicine, 7(7), 995-1016.
DOI Scopus60 WoS53 Europe PMC27
2012 McInnes, S. J. P., Szili, E. J., Al Bataineh, S. A., Xu, J., Alf, M. E., Gleason, K. K., . . . Voelcker, N. H. (2012). Combination of iCVD and porous silicon for the development of a controlled drug delivery system. ACS applied materials and interfaces, 4(7), 3566-3574.
DOI Scopus68 Europe PMC26
2011 Moore, E., McInnes, S. J., Vogt, A., & Voelcker, N. H. (2011). Rapid aqueous 'click chemistry' using Cu(I)-loaded dendrimers as macromolecular catalysts. Tetrahedron letters, 52(18), 2327-2329.
DOI WoS24
2011 Vasani, R., McInnes, S., Cole, M., Jani, A., Ellis, A., & Voelcker, N. (2011). Stimulus-responsiveness and drug release from porous silicon films ATRP-grafted with poly(N-isopropylacrylamide). Langmuir, 27(12), 7843-7853.
DOI Scopus105 WoS92 Europe PMC46
2009 Jani, A., Anglin, E., McInnes, S., Losic, D., Shapter, J., & Voelcker, N. (2009). Nanoporous anodic aluminium oxide membranes with layered surface chemistry. Chemical Communications, June 2009(21), 3062-3064.
DOI Scopus67 WoS69 Europe PMC33
2009 McInnes, S., & Voelcker, N. (2009). Silicon-polymer hybrid materials for drug delivery. Future Medicinal Chemistry, 1051(6), 1-1074.
2008 Nussio, M., Voelcker, N., Sykes, M. J., McInnes, S. J. P., Gibson, C., Lowe, R., . . . Shapter, J. (2008). Lateral heterogeneities in supported bilayers from pure and mixed phosphatidylethanolamine demonstrating hydrogen bonding capacity.. Biointerphases, 3(4), 96-104.
DOI Scopus13 WoS12 Europe PMC11

Year Citation
2018 McInnes, S. J. P., Turner, C. T., Cowin, A. J., & Voelcker, N. H. (2018). Wound management using porous silicon. In L. Canham (Ed.), Handbook of Porous Silicon: Second Edition (Vol. 2-2, pp. 1433-1452). Springer International Publishing.
DOI
2018 McInnes, S. J. P., Turner, C. T., Cowin, A. J., & Voelcker, N. H. (2018). Wound management using porous silicon. In L. Canham (Ed.), Source details - Title: Handbook of Porous Silicon: Second Edition (2 ed., pp. 1433-1452). Switzerland: Springer.
DOI
2015 McInnes, S. J. P., & Lowe, R. D. (2015). Biomedical uses of porous silicon. In D. Losic, & A. Santos (Eds.), Source details - Title: Electrochemically Engineered Nanoporous Materials (pp. 117-162). Switzerland: Springer.
DOI
2014 McInnes, S. J. P., & Voelcker, N. (2014). Porous silicon-polymer composites for cell culture and tissue engineering applications. In H. A. Santos (Ed.), Source details - Title: Porous silicon for biomedical applications (pp. 420-469). Cambridge, UK: Woodhead Publishing.
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Year Citation
2011 Kopermsub, P., Mayen, V., McInnes, S. J. P., & Voelcker, N. (2011). Fabrication and characterization of porous silicon nanoparticles for siRNA delivery. In Proceedings of the IEEE conference on nanotechnology (pp. 830-832). United States: IEEE.
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2009 Kakaday, T., Plunkett, S., McInnes, S. J. P., Jimmy, L. S., Voelcker, N., & Craig, J. (2009). Design of a wireless intraocular pressure monitoring system for a glaucoma drainage implant. In C. T. Lim, & J. C. Goh (Eds.), 13th International Conference on Biomedical Engineering IFMBE Proceedings Vol. 23 (pp. 198-201). US: Springer.
DOI Scopus1 WoS2
2008 Govindaraj, K. A., McInnes, S. J. P., Choudhury, N. R., Dutta, N. K., & Voelcker, N. (2008). Designing superhydrophobic surfaces using fluorosilsesquioxane-urethane hybrid and porous silicon gradients. In N. H. Voelcker, & H. W. Thissen (Eds.), Proc. SPIE Vol. 7267 (pp. 10 pages). Washington: SPIE.
DOI Scopus1
2008 Khung, Y., Cole, M., McInnes, S. J. P., & Voelcker, N. (2008). Control over wettability via surface modification of porous gradients. In D. V. Nicolau, D. Abbott, K. KalantarZadeh, T. DiMatteo, & S. M. Bezrukov (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE Vol. 6799 (pp. 12 pages). Australia: SPIE - The International Society for Optical Engineering.
DOI WoS2
2008 Kakaday, T., Plunkett, M., McInnes, S., Li, J. S. J., Voelcker, N. H., & Craig, J. E. (2008). Development of a wireless intra-ocular pressure monitoring system for incorporation into a therapeutic glaucoma drainage implant. In D. V. Nicolau, & G. Metcalfe (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE Vol. 7270 (pp. 11 pages). Melbourne, AUSTRALIA: SPIE-INT SOC OPTICAL ENGINEERING.
DOI Scopus1
2008 Zhou, J., McInnes, S. J. P., Jani, A. M., Ellis, A., & Voelcker, N. (2008). One-step surface modification of poly(dimethylsiloxane) by undecylenic acid. In N. H. Voelcker, & H. W. Thissen (Eds.), Smart Materials V: Proceedings of SPIE Vol. 7267 (pp. 726719:1-726719:10). US: SPIE - The International Society for Optical Engineering.
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Year Citation
2016 Voelcker, N. H., McInnes, S. J. P., Turner, C. T., & Cowin, A. J. (2016). WO/2016/172769, Compositions and methods for administering antibodies.

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