| 2025 |
Kan, W. L., Weekley, C. M., Nero, T. L., Hercus, T. R., Yip, K. H., Tumes, D. J., . . . Parker, M. W. (2025). The β Common Cytokine Receptor Family Reveals New Functional Paradigms From Structural Complexities. Immunological Reviews, 329(1), e13430-1-e13430-25.
DOI Scopus1 WoS3 Europe PMC1 |
| 2024 |
Thompson, E. J., Escarbe, S., Tvorogov, D., Farshid, G., Gregory, P. A., Khew-Goodall, Y., . . . Bonder, C. S. (2024). Interleukin-3 production by basal-like breast cancer cells is associated with poor prognosis. Growth Factors, 42(2), 49-61.
DOI Scopus2 WoS2 Europe PMC1 |
| 2024 |
Cildir, G., Aba, U., Pehlivan, D., Tvorogov, D., Warnock, N. I., Ipsir, C., . . . Erman, B. (2024). Defective kinase activity of IKKα leads to combined immunodeficiency and disruption of immune tolerance in humans. Nature Communications, 15(1), 9944-1-9944-18.
DOI Scopus1 WoS1 Europe PMC1 |
| 2023 |
Nair, P. C., Piehler, J., Tvorogov, D., Ross, D. M., Lopez, A. F., Gotlib, J., & Thomas, D. (2023). Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches. Blood Cancer Discovery, 4(5), 352-364.
DOI Scopus16 WoS13 Europe PMC12 |
| 2023 |
Kan, W. L., Dhagat, U., Hercus, T. R., Kaufmann, K. B., Nero, T. L., Zeng, A. G. X., . . . Lopez, A. (2023). Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia. Cancer Discovery, 13(8), 1922-1947.
DOI Scopus9 WoS8 Europe PMC9 |
| 2022 |
Tvorogov, D., Thompson-Peach, C. A. L., Foßelteder, J., Dottore, M., Stomski, F., Onnesha, S. A., . . . Lopez, A. F. (2022). Targeting human CALR-mutated MPN progenitors with a neoepitope-directed monoclonal antibody. EMBO Reports, 23(4), e52904-1-e52904-12.
DOI Scopus22 WoS22 Europe PMC21 |
| 2022 |
Brown, G. J., Cañete, P. F., Wang, H., Medhavy, A., Bones, J., Roco, J. A., . . . Vinuesa, C. G. (2022). TLR7 gain-of-function genetic variation causes human lupus. Nature, 605(7909), 349-356.
DOI Scopus401 WoS378 Europe PMC380 |
| 2021 |
Ross, D. M., Babon, J. J., Tvorogov, D., & Thomas, D. (2021). Persistence of myelofibrosis treated with ruxolitinib: biology and clinical implications. Haematologica, 106(5), 1244-1253.
DOI Scopus23 WoS22 Europe PMC18 |
| 2021 |
Kan, W. L., Cheung Tung Shing, K. S., Nero, T. L., Hercus, T. R., Tvorogov, D., Parker, M. W., & Lopez, A. F. (2021). Messing with βc: a unique receptor with many goals. Seminars in Immunology, 54(101513), 101513-1-101513-14.
DOI Scopus4 WoS4 Europe PMC4 |
| 2020 |
Dorstyn, L., Tvorogov, D., Malek, S., & Robinson, N. (2020). The 9th Barossa Meeting: Cell Signalling in Cancer Medicine. Cell Death and Disease, 11(3), 3 pages.
DOI |
| 2020 |
Ojala, V. K., Knittle, A. M., Kirjalainen, P., Merilahti, J. A. M., Kortesoja, M., Tvorogov, D., . . . Elenius, K. (2020). The guanine nucleotide exchange factor VAV3 participates in ERBB4-mediated cancer cell migration. Journal of Biological Chemistry, 295(33), 11559-11571.
DOI Scopus13 Europe PMC15 |
| 2018 |
Hercus, T., Kan, W., Broughton, S., Tvorogov, D., Ramshaw, H., Sandow, J., . . . Lopez, A. (2018). Role of the β common (βc) family of cytokines in health and disease. Cold Spring Harbor Perspectives in Biology, 10(6), a028514.
DOI Scopus42 WoS33 Europe PMC31 |
| 2018 |
Tvorogov, D., Thomas, D., Liau, N. P. D., Dottore, M., Barry, E. F., Lathi, M., . . . Lopez, A. F. (2018). Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis. Science Advances, 4(11), 1-12.
DOI Scopus46 WoS47 Europe PMC46 |
| 2015 |
Moldenhauer, L., Cockshell, M., Frost, L., Parham, K., Tvorogov, D., Tan, L., . . . Bonder, C. (2015). Interleukin-3 greatly expands non-adherent endothelial forming cells with pro-angiogenic properties. Stem Cell Research, 14(3), 380-395.
DOI Scopus17 WoS18 Europe PMC13 |
| 2015 |
Broughton, S. E., Nero, T. L., Dhagat, U., Kan, W. L., Hercus, T. R., Tvorogov, D., . . . Parker, M. W. (2015). The βc receptor family - Structural insights and their functional implications. Cytokine, 74(2), 247-258.
DOI Scopus69 WoS62 Europe PMC55 |
| 2014 |
Jeltsch, M., Jha, S. K., Tvorogov, D., Anisimov, A., Leppanen, V. M., Holopainen, T., . . . Alitalo, K. (2014). CCBE1 enhances lymphangiogenesis via a disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation. Circulation : journal of the American Heart Association, 129(19), 1962-1971.
DOI |
| 2014 |
Yao, L. C., Testini, C., Tvorogov, D., Anisimov, A., Vargas, S. O., Baluk, P., . . . McDonald, D. M. (2014). Pulmonary lymphangiectasia resulting from vascular endothelial growth factor-C overexpression during a critical period. Circulation Research, 114(5), 806-822.
DOI |
| 2013 |
Anisimov, A., Leppanen, V. M., Tvorogov, D., Zarkada, G., Jeltsch, M., Holopainen, T., . . . Alitalo, K. (2013). The basis for the distinct biological activities of vascular endothelial growth factor receptor-1 ligands. Science signaling, 6(282).
DOI |
| 2013 |
Leppänen, V. M., Tvorogov, D., Kisko, K., Prota, A. E., Jeltsch, M., Anisimov, A., . . . Alitalo, K. (2013). Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation. Proceedings of the National Academy of Sciences of the United States of America, 110(32), 12960-12965.
DOI |
| 2013 |
Anisimov, A., Tvorogov, D., Alitalo, A. K., Leppanen, V. M., An, Y., Han, E. C., . . . Alitalo, K. (2013). Vascular endothelial growth factor-angiopoietin chimera with improved properties for therapeutic angiogenesis. Circulation : journal of the American Heart Association, 127(4), 424-434.
DOI |
| 2012 |
Holopainen, T., Lopez Alpuche, V., Zheng, W., Heljasvaara, R., Jones, D., He, Y., . . . Alitalo, K. (2012). Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth. Cancer research, 72(14), 3512-3521.
DOI |
| 2012 |
Keuschnigg, J., Tvorogov, D., Elima, K., Salmi, M., Alitalo, K., Salminen, T., & Jalkanen, S. (2012). PV-1 is recognized by the PAL-E antibody and forms complexes with NRP-1. Blood, 120(1), 232-235.
DOI |
| 2011 |
Tammela, T., Zarkada, G., Nurmi, H., Jakobsson, L., Heinolainen, K., Tvorogov, D., . . . Alitalo, K. (2011). VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling. Nature cell biology, 13(10), 1202-1213.
DOI |
| 2011 |
Leppanen, V. M., Jeltsch, M., Anisimov, A., Tvorogov, D., Aho, K., Kalkkinen, N., . . . Alitalo, K. (2011). Structural determinants of vascular endothelial growth factor-D receptor binding and specificity. Blood, 117(5), 1507-1515.
DOI |
| 2010 |
Sundvall, M., Veikkolainen, V., Kurppa, K., Salah, Z., Tvorogov, D., van Zoelen, E. J., . . . Elenius, K. (2010). Cell death or survival promoted by alternative isoforms of ErbB4. Molecular Biology of the Cell, 21(23), 4275-4286.
DOI |
| 2010 |
Tvorogov, D., Anisimov, A., Zheng, W., Leppanen, V. M., Tammela, T., Laurinavicius, S., . . . Alitalo, K. (2010). Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization. Cancer Cell, 18(6), 630-640.
DOI |
| 2010 |
Zhou, F., Chang, Z., Zhang, L., Hong, Y. K., Shen, B., Wang, B., . . . He, Y. (2010). Akt/protein kinase B is required for lymphatic network formation, remodeling, and valve development. American Journal of Pathology, 177(4), 2124-2133.
DOI |
| 2009 |
Iivainen, E., Lauttia, S., Zhang, N., Tvorogov, D., Kulmala, J., Grenman, R., . . . Elenius, K. (2009). The EGFR inhibitor gefitinib suppresses recruitment of pericytes and bone marrow-derived perivascular cells into tumor vessels. Microvascular research, 78(3), 278-285.
DOI |
| 2009 |
Tvorogov, D., Sundvall, M., Kurppa, K., Hollmen, M., Johnson, M. S., & Elenius, K. (2009). Somatic mutations of ErbB4: selective loss-of-function phenotype affecting signal transduction pathways in cancer. Journal of biological chemistry, 284(9), 5582-5591.
DOI |
