Mitchell Lock

Dr Mitchell Lock

Research Fellow

School of Pharmacy and Biomedical Science

College of Health

Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.

Year Citation
2025 Amanollahi, R., Holman, S. L., Bertossa, M. R., Meakin, A. S., Clifton, V. L., Thornburg, K. L., . . . Morrison, J. L. (2025). Elevated cortisol concentration in preterm sheep fetuses impacts heart development. Experimental Physiology, online(12), 1-20.
DOI Scopus2 WoS2 Europe PMC1
2025 Amanollahi, R., Holman, S. L., Meakin, A. S., Padhee, M., Botting-Lawford, K. J., Zhang, S., . . . Morrison, J. L. (2025). In Vitro Embryo Culture Impacts Heart Mitochondria in Male Adolescent Sheep. Journal of Developmental Biology, 13(2), 17-1-17-20.
DOI
2025 Meakin, A. S., Lock, M. C., Holman, S. L., Robinson, J. L., Clifton, V. L., Roberts, C. T., . . . Morrison, J. L. (2025). Sex-specific effects of betamethasone on glucocorticoid and apoptotic signalling pathways in the sheep placenta. Journal of Physiology, 603(17), 4867-4886.
DOI
2025 Amanollahi, R., Meakin, A. S., Holman, S. L., Clifton, V. L., Thornburg, K. L., Wiese, M. D., . . . Morrison, J. L. (2025). Antenatal betamethasone impairs markers of cardiac development and function in near-term lambs. Experimental Physiology, online, EP093025-1-EP093025-20.
DOI
2025 Amanollahi, R., Holman, S. L., Bertossa, M. R., Meakin, A. S., Thornburg, K. L., McMillen, I. C., . . . Morrison, J. L. (2025). Ontogeny of Fetal Cardiometabolic Pathways: The Potential Role of Cortisol and Thyroid Hormones in Driving the Transition from Preterm to Near-Term Heart Development in Sheep. Journal of Cardiovascular Development and Disease, 12(2), 21 pages.
DOI Scopus6 WoS6 Europe PMC6
2025 Roff, A. J., Davies, A. N., Clifton, V. L., Stark, M. J., Tai, A., Robinson, J. L., . . . Gatford, K. L. (2025). Pregnancy does not affect progression of mild experimental asthma in sheep. The Journal of Physiology, 603(5), 1241-1261.
DOI Scopus2 WoS2 Europe PMC2
2025 Paramasivan, S., Lock, M. C., Barrero, R. A., Mills, P. C., Morrison, J. L., & Sadowski, P. (2025). Mitochondrial metabolic remodeling and multi-omics profiling identify plasma biomarkers of myocardial infarction. Journal of Molecular and Cellular Cardiology Plus, 14, 14 pages.
DOI
2025 Bertossa, M. R., Darby, J. R. T., Holman, S. L., Cho, S. K. S., Meakin, A. S., Lock, M. C., . . . Morrison, J. L. (2025). Fetal glucose availability: a key regulator of the metabolic, hormonal and contractility profiles of the fetal sheep heart. Journal of Physiology, 23 pages.
DOI
2024 Lock, M. C., Patey, O. V., Smith, K. L. M., Niu, Y., Jaggs, B., Trafford, A. W., . . . Galli, G. L. J. (2024). Maladaptive cardiomyocyte calcium handling in adult offspring of hypoxic pregnancy: protection by antenatal maternal melatonin. Journal of Physiology, 602(24), 6683-6703.
DOI Scopus3 WoS3 Europe PMC4
2024 Lock, M. C., Ripley, D. M., Smith, K. L. M., Mueller, C. A., Shiels, H. A., Crossley, D. A., & Galli, G. L. J. (2024). Developmental plasticity of the cardiovascular system in oviparous vertebrates: effects of chronic hypoxia and interactive stressors in the context of climate change. Journal of Experimental Biology, 227(20), 14 pages.
DOI Scopus7 WoS7 Europe PMC6
2024 Cho, S. K. S., Darby, J. R. T., Saini, B. S., Holman, S. L., Lock, M. C., Perumal, S. R., . . . Morrison, J. L. (2024). Late-gestation maternal undernutrition induces circulatory redistribution while preserving uteroplacental function independent of fetal glycaemic state. Journal of Physiology, 602(24), 7065-7083.
DOI Scopus3 WoS2 Europe PMC3
2024 Zhang, S., Lock, M. C., Tie, M., McMillen, I. C., Botting, K. J., & Morrison, J. L. (2024). Cardiac programming in the placentally restricted sheep fetus in early gestation. Journal of Physiology, 602(15), 3815-3832.
DOI Scopus5 WoS5 Europe PMC4
2023 Paramasivan, S., Morrison, J. L., Lock, M. C., Darby, J. R. T., Barrero, R. A., Mills, P. C., & Sadowski, P. (2023). Automated proteomics workflows for high-throughput library generation and biomarker detection using data-independent acquisition. Journal of proteome research, 22(6), 2018-2029.
DOI Scopus7 WoS7 Europe PMC6
2023 Padhee, M., Lock, M. C., McMillen, I. C., Zhang, S., Botting, K. J., Nyengaard, J. R., . . . Morrison, J. L. (2023). Sex-specific effects of in vitro culture and embryo transfer on cardiac growth in sheep offspring. Journal of Molecular and Cellular Cardiology Plus, 5(100039), 100039-1-100039-12.
DOI Scopus3 WoS2 Europe PMC2
2023 Lock, M. C., Botting, K. J., Allison, B. J., Niu, Y., Ford, S. G., Murphy, M. P., . . . Morrison, J. L. (2023). MitoQ as an antenatal antioxidant treatment improves markers of lung maturation in healthy and hypoxic pregnancy. Journal of Physiology, 601(16), 3647-3665.
DOI Scopus13 WoS14 Europe PMC11
2023 Galli, G. L. J., Lock, M. C., Smith, K. L. M., Giussani, D. A., & Crossley, D. A. (2023). Effects of Developmental Hypoxia on the Vertebrate Cardiovascular System. Physiology, 38(2), 9-+.
DOI Scopus22 WoS20 Europe PMC12
2022 Hansell, J. A., Richter, H. G., Camm, E. J., Herrera, E. A., Blanco, C. E., Villamor, E., . . . Giussani, D. A. (2022). Maternal melatonin: Effective intervention against developmental programming of cardiovascular dysfunction in adult offspring of complicated pregnancy. Journal of Pineal Research, 72(1), 18 pages.
DOI Scopus32 WoS29 Europe PMC27
2022 Smith, K. L. M., Swiderska, A., Lock, M. C., Graham, L., Iswari, W., Choudhary, T., . . . Galli, G. L. J. (2022). Chronic developmental hypoxia alters mitochondrial oxidative capacity and reactive oxygen species production in the fetal rat heart in a sex-dependent manner. Journal of Pineal Research, 73(3), 16 pages.
DOI Scopus28 WoS25 Europe PMC27
2021 Ren, J., Darby, J. R. T., Lock, M. C., Holman, S. L., Saini, B. S., Bradshaw, E. L., . . . Morrison, J. L. (2021). Impact of maternal late gestation undernutrition on surfactant maturation, pulmonary blood flow and oxygen delivery measured by magnetic resonance imaging in the sheep fetus. Journal of Physiology, 599(20), 4705-4724.
DOI Scopus11 WoS8 Europe PMC8
2021 Schrauben, E. M., Darby, J. R. T., Berry, M. J., Saini, B. S., Quinn, M., Holman, S. L., . . . Morrison, J. L. (2021). Open or closed: Changes in ductus arteriosus flow patterns at birth using 4D flow MRI in newborn piglets. Physiological Reports, 9(17), 15 pages.
DOI Scopus5 WoS5 Europe PMC6
2021 Saini, B. S., Darby, J. R. T., Marini, D., Portnoy, S., Lock, M. C., Soo, J. Y., . . . Seed, M. (2021). An MRI approach to assess placental function in healthy humans and sheep. The Journal of Physiology, 599(10), 2573-2602.
DOI Scopus26 WoS23 Europe PMC24
2021 Aujla, T., Darby, J. R. T., Saini, B. S., Lock, M. C., Holman, S. L., Bradshaw, E. L., . . . Morrison, J. L. (2021). Impact of resveratrol-mediated increase in uterine artery blood flow on fetal haemodynamics, blood pressure and oxygenation in sheep. Experimental Physiology, 106(5), 1166-1180.
DOI Scopus9 WoS9 Europe PMC9
2021 Lock, M. C., Botting, K. J., Niu, Y., Ford, S. G., Orgeig, S., Giussani, D. A., & Morrison, J. L. (2021). Dexamethasone reduces 11b-hydroxysteroid dehydrogenase 1 expression the fetal lung following hypoxic pregnancy. Reproductive Sciences, 28(S1), 260.
2021 Ren, J., Lock, M. C., Darby, J. R. T., Orgeig, S., Holman, S. L., Quinn, M., . . . Morrison, J. L. (2021). PPARγ activation in late gestation does not promote surfactant maturation in the fetal sheep lung. Journal of Developmental Origins of Health and Disease, 12(6), 963-974.
DOI Scopus4 WoS12 Europe PMC3
2021 McBride, G. M., Meakin, A. S., Soo, J. Y., Darby, J. R. T., Varcoe, T. J., Bradshaw, E. L., . . . Morrison, J. L. (2021). Intrauterine growth restriction alters the activity of drug metabolising enzymes in the maternal-placental-fetal unit. Life Sciences, 285(120016), 1-9.
DOI Scopus21 WoS20 Europe PMC16
2020 Darby, J. R. T., Sorvina, A., Bader, C. A., Lock, M. C., Soo, J. Y., Holman, S. L., . . . Morrison, J. L. (2020). Detecting metabolic differences in fetal and adult sheep adipose and skeletal muscle tissues. Journal of Biophotonics, 13(3), e201960085-1-e201960085-13.
DOI Scopus16 WoS17 Europe PMC14
2020 Lock, M. C., Tellam, R. L., Darby, J. R. T., Soo, J. Y., Brooks, D. A., Macgowan, C. K., . . . Morrison, J. L. (2020). Differential gene responses 3 days following infarction in the fetal and adolescent sheep heart. Physiological Genomics, 52(3), 143-159.
DOI Scopus6 WoS5 Europe PMC4
2020 Lock, M. C., Tellam, R. L., Darby, J. R. T., Soo, J. Y., Brooks, D. A., Seed, M., . . . Morrison, J. L. (2020). Identification of novel miRNAs involved in cardiac repair following infarction in fetal and adolescent sheep hearts. Frontiers in Physiology, 11(article no. 614), 614-1-614-21.
DOI Scopus9 WoS9 Europe PMC8
2020 Cho, S. K. S., Darby, J. T. R., Saini, B. S., Lock, M. C., Holman, S. L., Lim, J. M., . . . Seed, M. (2020). Feasibility of ventricular volumetry by cardiovascular MRI to assess cardiac function in the fetal sheep. The Journal of Physiology, 598(13), 2557-2573.
DOI Scopus24 WoS22 Europe PMC20
2020 Saini, B. S., Darby, J. R. T., Portnoy, S., Sun, L., van Amerom, J., Lock, M. C., . . . Seed, M. (2020). Normal human and sheep fetal vessel oxygen saturations by T2 magnetic resonance imaging. The Journal of Physiology, 598(15), 3259-3281.
DOI Scopus59 WoS53 Europe PMC49
2020 Schrauben, E. M., Darby, J. R. T., Saini, B. S., Holman, S. L., Lock, M. C., Perumal, S. R., . . . Macgowan, C. K. (2020). Technique for comprehensive fetal hepatic blood flow assessment in sheep using 4D flow MRI. Journal of Physiology, 598(17), 3555-3567.
DOI Scopus9 WoS9 Europe PMC9
2019 Darby, J. R. T., Saini, B. S., Soo, J. Y., Lock, M. C., Holman, S. L., Bradshaw, E. L., . . . Morrison, J. L. (2019). Subcutaneous maternal resveratrol treatment increases uterine artery blood flow in the pregnant ewe and increases fetal but not cardiac growth. The journal of physiology, 597(20), 5063-5077.
DOI Scopus40 WoS39 Europe PMC34
2019 Duan, A. Q., Darby, J. R. T., Soo, J. Y., Lock, M. C., Zhu, M. Y., Flynn, L. V., . . . Seed, M. (2019). Feasibility of phase-contrast cine magnetic resonance imaging for measuring blood flow in the sheep fetus. American journal of physiology - Regulatory integrative and comparative physiology, 317(6), R780-R792.
DOI Scopus36 WoS36 Europe PMC25
2019 Schrauben, E. M., Saini, B. S., Darby, J. R. T., Soo, J. Y., Lock, M. C., Stirrat, E., . . . MacGowan, C. K. (2019). Fetal hemodynamics and cardiac streaming assessed by 4D flow cardiovascular magnetic resonance in fetal sheep. Journal of cardiovascular magnetic resonance, 21(article no 8), 1-11.
DOI Scopus51 WoS53 Europe PMC48
2019 Clifton, V. L., McDonald, M., Morrison, J. L., Holman, S. L., Lock, M. C., Saif, Z., . . . Moss, T. J. M. (2019). Placental glucocorticoid receptor isoforms in a sheep model of maternal allergic asthma. Placenta, 83, 33-36.
DOI Scopus17 WoS17 Europe PMC14
2019 Lock, M. C., Darby, J. R. T., Soo, J. Y., Brooks, D. A., Perumal, S. R., Selvanayagam, J. B., . . . Morrison, J. L. (2019). Differential response to injury in fetal and adolescent sheep hearts in the immediate post in the immediate post-myocardial myocardial myocardial infarction period. Frontiers in Physiology, 10(208), 208-1-208-24.
DOI Scopus31 WoS32 Europe PMC31
2018 Lock, M. C., Tellam, R. L., Botting, K. J., Wang, K. C. W., Selvanayagam, J. B., Brooks, D. A., . . . Morrison, J. L. (2018). The role of miRNA regulation in fetal cardiomyocytes, cardiac maturation and the risk of heart disease in adults. The Journal of Physiology, 596(23), 5625-5640.
DOI Scopus45 WoS38 Europe PMC36
2018 Sorvina, A., Bader, C. A., Darby, J. R. T., Lock, M. C., Soo, J. Y., Johnson, I. R. D., . . . Brooks, D. A. (2018). Mitochondrial imaging in live or fixed tissues using a luminescent iridium complex. Scientific Reports, 8(1, article no. 8191), 8191-1-8191-8.
DOI Scopus33 WoS29 Europe PMC22
2018 Morrison, J. L., Berry, M. J., Botting, K. J., Darby, J. R., Frasch, M. G., Gatford, K. L., . . . Tellam, R. L. (2018). Improving pregnancy outcomes in humans through studies in sheep. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 315(6), 1123-1153.
DOI Scopus148 WoS141 Europe PMC129
2018 Sorvina, A., Bader, C., Lock, M., Brooks, D., Morrison, J., & Plush, S. (2018). Label-free imaging of healthy and infarcted fetal sheep hearts by two-photon microscopy. Journal of Biophotonics, 11(1), e201600296-1-e201600296-8.
DOI Scopus6 WoS4 Europe PMC5
2018 Morrison, J., Sorvina, A., Darby, J., Bader, C., Lock, M., Seed, M., . . . Brooks, D. (2018). Label-free imaging of redox status and collagen deposition showing metabolic differences in the heart. Journal of Biophotonics, 11(3), e20170024-12-e201700242-7.
DOI Scopus5 WoS6 Europe PMC4
2017 Lock, M., McGillick, E., Orgeig, S., McMillen, I., Mühlhäusler, B., Zhang, S., & Morrison, J. (2017). Differential effects of late gestation maternal overnutrition on the regulation of surfactant maturation in fetal and postnatal life. The Journal of physiology, 595(21), 6635-6652.
DOI Scopus24 WoS23 Europe PMC22
2017 Lock, M. C., Botting, K. J., Tellam, R. L., Brooks, D., & Morrison, J. L. (2017). Adverse intrauterine environment and cardiac miRNA expression. International Journal of Molecular Sciences, 18(12), 2628-1-2628-19.
DOI Scopus26 WoS24 Europe PMC19
2017 McGillick, E. V., Lock, M. C., Orgeig, S., & Morrison, J. (2017). Maternal obesity mediated predisposition to respiratory complications at birth and in later life: understanding the implications of the obesogenic intrauterine environment. Paediatric respiratory reviews, 21, 11-18.
DOI Scopus51 WoS45 Europe PMC38
2017 Duan, A. Q., Lock, M. C., Perumal, S. R., Darby, J. R., Soo, J. Y., Selvanayagam, J. B., . . . Morrison, J. L. (2017). Feasibility of detecting myocardial infarction in the sheep fetus using late gadolinium enhancement CMR imaging. Journal of cardiovascular magnetic resonance, 19(1, article no, 69), 1-11.
DOI Scopus35 WoS32 Europe PMC31
2016 Lock, M., Tellam, R., Porrello, E., Soo, J., Darby, J., Brooks, D., & Morrison, J. (2016). miR-133a and target gene expression in the foetus and 6 month old sheep heart in response to myocardial infarction. Heart, lung and circulation, 25(S2), 117.
DOI
2015 Lock, M., McGillick, E., Orgeig, S., Zhang, S., McMillen, I., & Morrison, J. (2015). Mature Surfactant Protein-B Expression by Immunohistochemistry as a Marker for Surfactant System Development in the Fetal Sheep Lung. Journal of Histochemistry and Cytochemistry, 63(11), 866-878.
DOI Scopus25 WoS23 Europe PMC19
2013 Lock, M., McGillick, E. V., Orgeig, S., McMillen, I. C., & Morrison, J. L. (2013). Regulation of fetal lung development in response to maternal overnutrition. Clinical and experimental pharmacology and physiology, 40(11), 803-816.
DOI Scopus43 WoS39 Europe PMC32
1977 LOCK, M. C. (1977). COMBAT STRESS WITH AN ANCIENT, COST-FREE THERAPY. CHEMICAL ENGINEERING, 84(11), 167-168.

Year Citation
2025 Smith, K. L., Swiderska, A., Lock, M. C., Iswari, W., Choudhary, T., Thomas, D., . . . Galli, G. L. (2025). Melatonin reduces mitochondrial oxidative stress in the placenta in a rat model of chronic fetal hypoxia. In ACTA PHYSIOLOGICA Vol. 241 (pp. 1 page). WILEY.
2024 Lock, M. C., Smith, K. L. M., Niu, Y., Patey, O. V., Li, Y., Ford, S. G., . . . Galli, G. L. J. (2024). Melatonin Treatment Improves an Increased Susceptibility to Cardiac Ventricular Arrhythmias in Adult Offspring Exposed to Developmental Hypoxia.. In REPRODUCTIVE SCIENCES Vol. 31 (pp. 220A). CANADA, Vancouver: SPRINGER HEIDELBERG.
2024 Chow, J. S. M., Lock, M. C., Charest-Pekeski, A. J., Cho, S. K. S., Holman, S. L., Saini, B. S., . . . Morrison, J. L. (2024). Support on a Pumped Artificial Placenta Circuit Increases Cardiac Energy Demand in a Fetal Pig Model.. In REPRODUCTIVE SCIENCES Vol. 31 (pp. 99A-100A). CANADA, Vancouver: SPRINGER HEIDELBERG.
2022 Lock, M. C., Smith, K. L., Niu, Y., Patey, O. V., Ford, S. G., Trafford, A. W., . . . Galli, G. L. (2022). Developmental Hypoxia Increases Susceptibility to Cardiac Ventricular Arrhythmias in Adult Offspring. In ACTA PHYSIOLOGICA Vol. 236 (pp. 917-919). WILEY.
2022 Patey, O. V., Lock, M., Niu, Y., Ford, S., Jaggs, B., Conrado, C. M., . . . Giussani, D. A. (2022). Maternal Melatonin < Effective Intervention Against Programmed Heart Disease Male and Female Adult Offspring of Hypoxic Pregnancy. In REPRODUCTIVE SCIENCES Vol. 29 (pp. 63). CO, Denver: SPRINGER HEIDELBERG.
2022 Smith, K. L. M., Swiderska, A., Lock, M. C., Graham, L., Iswari, W., Choudhary, T., . . . Galli, G. L. J. (2022). Gestational Hypoxia Alters Fetal Cardiac Mitochondrial Function and Reactive Oxygen Species Production in a Sex-Dependent Manner. In REPRODUCTIVE SCIENCES Vol. 29 (pp. 65). SPRINGER HEIDELBERG.
2022 Lock, M. C., Kerri, S. L. M., Youguo, N., Patey, O. V., Ford, S. G., Trafford, A. W., . . . Galli, G. L. J. (2022). Susceptibility to Arrhythmia in Offspring of Hypoxic Pregnancy: Spontaneous Calcium Release in Isolated Cardiomyocytes. In REPRODUCTIVE SCIENCES Vol. 29 (pp. 78). SPRINGER HEIDELBERG.
2021 Lock, M. C., Smith, K. L. M., Niu, Y., Patey, O. V., Ford, S. G., Trafford, A. W., . . . Galli, G. L. J. (2021). Maladaptive Cardiomyocyte Calcium Handling in Adult Offspring of Hypoxic Pregnancy: Protection by Antenatal Maternal Melatonin.. In REPRODUCTIVE SCIENCES Vol. 28 (pp. 87A). SPRINGER HEIDELBERG.
2021 Lock, M. C., Botting, K. J., Niu, Y., Ford, S. G., Orgeig, S., Giussani, D. A., & Morrison, J. L. (2021). Dexamethasone Reduces 11β-Hydroxysteroid Dehydrogenase 1 Expression the Fetal Lung Following Hypoxic Pregnancy.. In REPRODUCTIVE SCIENCES Vol. 28 (pp. 260A). SPRINGER HEIDELBERG.
2020 Cho, S. K. S., Darby, J. R. T., Saini, B. S., Lock, M. C., Holman, S. L., Perumal, S. R., . . . Morrison, J. L. (2020). Late Gestation Maternal Undernutrition Increases Cardiac Function and Combined Ventricular Output Measured by Cardiac MRI (CMR).. In REPRODUCTIVE SCIENCES Vol. 27 (pp. 237A-238A). CANADA, Vancouver: SPRINGER HEIDELBERG.
2020 Aujla, T., Darby, J. R. T., Saini, B. S., Soo, J. Y., Lock, M. C., Holman, S. L., . . . Morrison, J. L. (2020). Sustained Slow Release Resveratrol to the Mother and Fetal Blood Flow and Oxygenation Measured with MRI.. In REPRODUCTIVE SCIENCES Vol. 27 (pp. 153A). CANADA, Vancouver: SPRINGER HEIDELBERG.
2019 Saini, B. S., Darby, J. R. T., Portnoy, S., Perumal, S. R., Soo, J. Y., Lock, M. C., . . . Morrison, J. L. (2019). Validation of Fetal MRI Oximetry.. In REPRODUCTIVE SCIENCES Vol. 26 (pp. 152A). FRANCE, Paris: SAGE PUBLICATIONS INC.
2019 Lock, M. C., Botting, K. J., Niu, Y., Ford, S. G., Orgeig, S., Giussani, D. A., & Morrison, J. L. (2019). Dexamethasone Promotes Surfactant Maturation and Hypoxia Signalling in the Fetal Lung Following Hypoxic Pregnancy.. In REPRODUCTIVE SCIENCES Vol. 26 (pp. 337A). FRANCE, Paris: SAGE PUBLICATIONS INC.
2018 Darby, J. R. T., Sorvina, A., Bader, C., Lock, M., Soo, J. Y., Seed, M., . . . Morrison, J. L. (2018). Redox Ratio is Higher in White Adipose Tissue Compared to Brown Adipose Tissue. In REPRODUCTIVE SCIENCES Vol. 25 (pp. 139A-140A). CA, San Diego: SAGE PUBLICATIONS INC.
2017 Lock, M., Soo, J. Y., Darby, J., Brooks, D., Porrello, E., Tellam, R., & Morrison, J. (2017). Cardiac miRNA Expression in the Fetus and Six Month Old Sheep in Response to Myocardial Infarction.. In REPRODUCTIVE SCIENCES Vol. 24 (pp. 97A). FL, Orlando: SAGE PUBLICATIONS INC.

Date Role Research Topic Program Degree Type Student Load Student Name
2025 Co-Supervisor - Doctor of Philosophy Doctorate Full Time Mrs Sheila Mizani

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