Jantina Manning

Dr Jantina Manning

Research Fellow

Centre for Cancer Biology

College of Health

Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.

Available For Media Comment.

Dr Jantina Manning is an accomplished early career researcher at the Centre for Cancer Biology, University of South Australia, and a tutor for several undergraduate subjects. She has developed and led a research project focused on characterising a new gene, Nedd4-2, in kidney homeostasis, disease and diabetes, resulting in 21 peer reviewed articles in high impact factor journals. Her work has been recognised with grants, fellowships and awards, and she regularly contributes to the scientific community including through peer review and committee leadership.
Research:
Dr Manning's research expertise lies in the study of fundamental molecular and cellular biological processes, animal models and translation into human clinical relevance. You can learn more about her research in the following YouTube videos:

The enzyme that could help 700 million people with chronic kidney disease
How genetics play a role in diabetic kidney disease

Teaching:
Since 2021, has also been active in delivering first-year tutorials, practicals, workshops and lectures for Human Body 1/2, and Biology A/B at the University of South Australia. Her passion for guiding students and instilling an appetite for learning has driven her to pursue additional teaching roles. She is dedicated to improving her own teaching and scholarship of teaching and learning.

Identified NEDD4L as a key player in diabetic kidney disease

Discovered NEDD4-2 as an important enzyme in kidney homeostasis

Demonstrated salt-sensitive kidney disease caused by NEDD-2 deficiency

Identified NEDD4 interacting partners important in testes development

Year Citation
2025 Umargamwala, R., Nicolson, S., Manning, J., Carosi, J. M., Kumar, S., & Denton, D. (2025). Identification of new candidates regulating autophagy-dependent midgut degradation in Drosophila melanogaster. Cell Death Discovery, 11(181), 181-1-181-13.
DOI Scopus1 WoS1 Europe PMC1
2025 Manning, J. A., Jesudason, S., Moretti, P. A. B., Pitson, S. M., Chou, A. S. Y., Shabbar, M., . . . Kumar, S. (2025). Nedd4-2 ablation in kidney improves glycaemic control in diabetic mice. Cell Death and Disease, 16(496), 1-23.
DOI Scopus1 WoS1 Europe PMC1
2025 Shabbar, M., Manning, J., Lim, Y., Shah, S., Sinha, D., Nikolic, A., . . . Kumar, S. (2025). Phospholipid scramblase 1 (PLSCR1) is a novel substrate of NEDD4-2 (NEDD4L) mediated ubiquitination. Cell Death Discovery, 11(1, article no. 393), 1-11.
DOI Scopus1 WoS1
2025 Shah, S. S., Manning, J. A., Lim, Y., Sinha, D., Murthy, A. M. V., Ganesan, R., . . . Kumar, S. (2025). NEDD4L-mediated Gasdermin D and E ubiquitination regulates cell death and tissue injury.. Cell Death Differ, online, 1-18.
DOI
2024 Nicolson, S., Manning, J. A., Lim, Y., Jiang, X., Kolze, E., Dayan, S., . . . Denton, D. (2024). The Drosophila ZNRF1/2 homologue, detour, interacts with HOPS complex and regulates autophagy. Communications Biology, 7(1), 183-1-183-24.
DOI Scopus5 WoS3 Europe PMC4
2024 Umargamwala, R., Manning, J., Dorstyn, L., Denton, D., & Kumar, S. (2024). Understanding Developmental Cell Death Using Drosophila as a Model System. Cells, 13(4), 347-1-347-16.
DOI Scopus3 WoS2 Europe PMC1
2023 Leung, P. Y. M., Katerelos, M., Choy, S., Cook, N., Lee, M., Paizis, K., . . . Power, D. A. (2023). Expression of NEDD4L and ENaC in Urinary extracellular vesicles in pre-eclampsia. Hypertension In Pregnancy, 42(1, article no. 2232029), 1-9.
DOI Scopus4 WoS4 Europe PMC3
2022 Farooq, A. U., Gembus, K., Sandow, J. J., Webb, A., Mathivanan, S., Manning, J. A., . . . Kumar, S. (2022). K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis. Journal of Extracellular Vesicles, 11(2), e12188-1-e12188-15.
DOI Scopus14 WoS13 Europe PMC10
2021 Xu, T., Nicolson, S., Sandow, J. J., Dayan, S., Jiang, X., Manning, J. A., . . . Denton, D. (2021). Cp1/cathepsin L is required for autolysosomal clearance in Drosophila. Autophagy, 17(10), 2734-2749.
DOI Scopus12 WoS13 Europe PMC16
2021 Manning, J. A., Shah, S. S., Nikolic, A., Henshall, T. L., Khew-Goodall, Y., & Kumar, S. (2021). The ubiquitin ligase NEDD4-2/NEDD4L regulates both sodium homeostasis and fibrotic signaling to prevent end-stage renal disease. Cell Death and Disease, 12(4), 398-1-398-16.
DOI Scopus19 WoS18 Europe PMC14
2020 Manning, J. A., Shah, S. S., Henshall, T. L., Nikolic, A., Finnie, J., & Kumar, S. (2020). Dietary sodium modulates nephropathy in Nedd4-2-deficient mice. Cell Death and Differentiation, 27(6), 1832-1843.
DOI Scopus11 WoS10 Europe PMC11
2020 Manning, J. A., Windley, S. P., Sandow, J. J., Shah, S. S., Western, P., Wilhelm, D., & Kumar, S. (2020). Identification of novel interacting partners of the NEDD4 ubiquitin ligase in mouse testis.. Journal of Proteomics, 223(103830), 103830-1-103830-8.
DOI Scopus3 WoS3 Europe PMC3
2018 Manning, J. A., & Kumar, S. (2018). Physiological functions of nedd4-2: lessons from knockout mouse models. Trends in Biochemical Sciences, 43(8), 635-647.
DOI Scopus60 WoS63 Europe PMC57
2017 Manning, J. A., Henshall, T. L., & Kumar, S. (2017). NEDD4-2-dependent control of Na⁺ homeostasis and renal disease. Cell cycle, 17(1), 1-2.
DOI Scopus8 WoS9 Europe PMC11
2017 Henshall, T., Manning, J., Alfassy, O., Goel, P., Boase, N., Kawabe, H., & Kumar, S. (2017). Deletion of Nedd4-2 results in progressive kidney disease in mice. Cell Death and Differentiation, 24(12), 2150-2160.
DOI Scopus31 WoS32 Europe PMC29
2015 Goel, P., Manning, J., & Kumar, S. (2015). NEDD4-2 (NEDD4L): the ubiquitin ligase for multiple membrane proteins. Gene, 557(1), 1-10.
DOI Scopus145 WoS146 Europe PMC132
2014 Ekberg, J., Boase, N., Rychkov, G., Manning, J., Poronnik, P., & Kumar, S. (2014). Nedd4-2 (NEDD4L) controls intracellular Na⁺ -mediated activity of voltage-gated sodium channels in primary cortical neurons. Biochemical Journal, 457(1), 27-31.
DOI Scopus33 WoS33 Europe PMC32
2010 Manning, J., & Kumar, S. (2010). A potential role for NEDD1 and the centrosome in senescence of mouse embryonic fibroblasts. Cell Death & Disease, 1(4), E35-1-E35-8.
DOI Scopus29 WoS31 Europe PMC33
2010 Manning, J., Shalini, S., Risk, J., Day, C., & Kumar, S. (2010). A direct interaction with NEDD1 regulates γ-tubulin recruitment to the centrosome. PLoS One, 5(3), 1-12.
DOI Scopus39 WoS41 Europe PMC40
2010 Manning, J., Lewis, M., Koblar, S., & Kumar, S. (2010). An essential function for the centrosomal protein NEDD1 in zebrafish development. Cell Death and Differentiation, 17(8), 1302-1314.
DOI Scopus13 WoS13 Europe PMC14
2008 Manning, J., Colussi, P., Koblar, S., & Kumar, S. (2008). Nedd1 expression as a marker of dynamic centrosomal localization during mouse embryonic development. Histochemistry and Cell Biology, 129(6), 751-764.
DOI Scopus14 WoS15 Europe PMC14
2007 Manning, J., & Kumar, S. (2007). NEDD1: Function in microtubule nucleation spindle assembly and beyond. International Journal of Biochemistry & Cell Biology, 39(1), 7-11.
DOI Scopus25 WoS25 Europe PMC24
2007 Ekberg, J., Schuetz, F., Boase, N. A., Conroy, S. J., Manning, J., Kumar, S., . . . Adams, D. J. (2007). Regulation of the voltage-gated K+ channels KCNQ2/3 and KCNQ3/5 by ubiquitination: Novel role for Nedd4-2. Journal of Biological Chemistry, 282(16), 12135-12142.
DOI Scopus81 WoS79 Europe PMC73
2006 Kumar, R., Manning, J., Spendlove, H., Kremmidiotis, G., McKirdy, R., Lee, J., . . . Callen, D. (2006). ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription. Molecular Cancer Research, 4(9), 655-665.
DOI Scopus47 WoS44 Europe PMC43

Year Citation
2025 Thyagarajan, N., Le Leu, R., Kumar, S., Jesudason, S., & Manning, J. (2025). Increased Urinary Extracellular Vesicles And Reduced Expression of NEDD4L in Diabetic Nephropathy-A Pilot Study. In NEPHROLOGY Vol. 30 (pp. 1 page). WILEY.
2025 Manning, J., Jesudason, S., Moretti, P., Pitson, S., Shabbar, M., & Kumar, S. (2025). NEDD4-2 Ablation in Kidney Improves Glycaemic Control in Diabetic Mice. In NEPHROLOGY Vol. 30 (pp. 1 page). WILEY.
2024 Manning, J., Jesudason, S., & Kumar, S. (2024). RENAL NEDD4L AS A POTENTIAL NEW REGULATOR OF GLUCOSE HOMEOSTASIS AND DIABETIC NEPHROPATHY. In NEPHROLOGY Vol. 29 (pp. 29). WILEY.
2023 Manning, J., Jesudason, S., & Kumar, S. (2023). NEDD4L AS A NEW REGULATOR OF DIABETIC NEPHROPATHY AND CHRONIC KIDNEY DISEASE. In NEPHROLOGY Vol. 28 (pp. 67). WILEY.

Date Role Research Topic Program Degree Type Student Load Student Name
2022 Co-Supervisor - Doctor of Philosophy Doctorate Full Time Ruchi Umargamwala
2022 Co-Supervisor - Doctor of Philosophy Doctorate Full Time Miss Diva Sinha
2021 Co-Supervisor - Doctor of Philosophy Doctorate Full Time Mrs Meriam Shabbar

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