Dr Julia Kuliwaba

Senior Research Funding Officer (Pre-Award)

Research Services

Division of Research and Innovation

Dr Julia Kuliwaba is a Senior Research Fellow and Head of the Bone and Joint Research Group in the Centre for Orthopaedic and Trauma Research, Adelaide Medical School, The University of Adelaide. Dr Kuliwaba has over 20 years research experience in the musculoskeletal field, with her research focus on understanding the pathobiology of Osteoarthritis, Osteoporosis, and other musculoskeletal conditions. She is actively involved with supervision of PhD and Honours research students and undergraduate teaching and research project supervision in the Adelaide Medical School, The University of Adelaide.

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Bone and Joint Research Group, Centre for Orthopaedic and Trauma Research

The Bone and Joint Research Group focus on understanding the pathobiology of Osteoarthritis, Osteoporosis, and other musculoskeletal conditions. The laboratory is internationally recognised for human tissue-level analyses, utilising a well-established human musculoskeletal tissue bank. The research involves a multidisciplinary approach utilising numerous tissue-level techniques: ranging from molecular to microstructural to clinical imaging.

Lead researcher: Dr Julia Kuliwaba

Email: julia.kuliwaba@adelaide.edu.au

Research Project 1

Title: TGF-beta as a critical factor in human osteoarthritis

Project description: The aetiology of the painful degenerative joint disease osteoarthritis (OA) has so far been elusive, blocking the development of disease modifying treatments. Exciting recent research in mice has found that TGF-beta over-expression in the subchondral bone (beneath the cartilage) has a critical causal role in OA pathogenesis. The OA bone changes seen in mice closely resemble what we find in human OA bone in zones that display the most severe changes, which correspond to ‘bone marrow lesions’ identified by magnetic resonance imaging (MRI). This research project area will investigate the link between TGF-beta expression with structural, chemical compositional, cellular and molecular changes in human subchondral bone marrow lesions. The research involves the analysis of human knee and/or hip OA tissue specimens. This project will investigate TGF-beta as a candidate driver of human OA, which is an essential precursor to testing pharmacologic alteration of TGF-beta activity as a therapeutic strategy.

Projects available for: Third Year / Honours / HDR / Masters

Location: Adelaide Health and Medical Sciences building (AHMS)

Research project start: Semester 1 and 2

Research Project 2

Title: Clinical imaging and tissue-level phenotyping of human hip osteoarthritis

Project description: In Australia, 1 in 4 individuals is at risk of developing symptomatic hip osteoarthritis (OA) in their lifetime. People with hip OA have significant pain and disability, which affects their quality of life. Clinical diagnosis of hip OA involves symptomatic and imaging findings; imaging characteristics include joint space narrowing, presence of osteophytes, subchondral bone cysts and bone marrow lesions (BMLs). A more painful and progressive subtype of hip OA is thought to be related to the formation of subchondral bone cysts, which may develop from BMLs that are often seen in pre-OA populations. The future development of preventive therapy and therapeutic approaches for OA depends on early prediction, detection and prognosis. Thus, it is essential to understand the relationship between subchondral bone cysts and BMLs in hip OA. This project will investigate the frequency and location of subchondral bone cysts and BMLs in hip OA patients using magnetic resonance imaging (MRI). The presence of these MRI features will be associated with OA progression, evaluated by cartilage volume loss, radiographic KL score and histopathological OARSI cartilage grade. Bone tissue changes will also be assessed in relation to cysts and BMLs by analysis of bone microarchitecture, bone remodelling and microdamage accumulation.

Projects available for: Third Year / Honours / HDR / Masters

Location: Adelaide Health and Medical Sciences building (AHMS)

Research project start: Semester 1 and 2

Research Project 3

Title: Compositional mapping of the cartilage-bone unit in human knee osteoarthritis: insight into disease pathobiology

Project description: Osteoarthritis (OA) is a common painful degenerative disease of the joints, which constitutes a major and growing health problem for the ageing Australian population, and for which there are no effective therapies. Our recent research in human OA has shown the involvement of the bone under the cartilage, i.e. subchondral bone, in the development of OA. There is limited quantitative understanding of the tissue matrix composition of the cartilage-bone unit in human OA. This project will utilise Fourier Transform InfraRed (FTIR) and Raman spectroscopic imaging to map region-specific changes in bone and cartilage matrix composition, eg. collagen organisation, proteoglycan and mineral distribution, for human tissue specimens. This project will use an available cohort of OA and non-OA tibial plateau specimens that has been characterised by MRI-imaging for the presence/absence of bone marrow lesions (BMLs) in the subchondral bone. BMLs are of clinical importance as they are associated with pain, predict disease progression, and may be useful as outcome measures for intervention strategies. This project will deliver new knowledge of the cartilage-bone matrix composition for human knee OA patients with and without subchondral BMLs and provide insight into the pathobiology of OA disease progression.

Projects available for: Third Year / Honours / HDR / Masters

Location: Adelaide Health and Medical Sciences building (AHMS)

Research project start: Semester 1 and 2

Appointments

Date Position Institution name

2015 - ongoing Research Fellow The University of Adelaide

Date	Position	Institution name
2015 - ongoing	Research Fellow	The University of Adelaide

Education

Institution name	Country	Title
The University of Adelaide	Australia	PhD (High Commendation)
The University of Adelaide	Australia	BSc (Hons)
The University of Adelaide	Australia	BSc

Research Interests

Ageing, Frailty and Mobility Musculoskeletal Health Arthritis & Rheumatology Biochemistry & Molecular Biology Biochemistry and Cell Biology Bone and Bones Chemical Characterisation of Materials Microscopy Orthopaedics Pathology Rheumatology and Arthritis Spine

Journals

Year	Citation
2023	Lee, Y. -R., Briggs, M. T., Kuliwaba, J. S., Jagiello, J., Anderson, P. H., & Hoffmann, P. (2023). Complex-Type <i>N</i>-Glycans Are Associated with Cartilage Degeneration within Different Loading Sites of the Tibial Plateau for Knee Osteoarthritis Patients. Journal of Proteome Research, 22(8), 2694-2702. DOI Scopus1
2023	Lee, Y. -R., Briggs, M. T., Kuliwaba, J. S., Jagiello, J., Anderson, P. H., & Hoffmann, P. (2023). High-Resolution <i>N</i>-Glycan MALDI Mass Spectrometry Imaging of Subchondral Bone Tissue Microarrays in Patients with Knee Osteoarthritis. Analytical Chemistry, 95(34), 12575-12992. DOI Scopus2 Europe PMC1
2022	Muratovic, D., Findlay, D. M., Quarrington, R. D., Cao, X., Solomon, L. B., Atkins, G. J., & Kuliwaba, J. S. (2022). Elevated levels of active Transforming Growth Factor β1 in the subchondral bone relate spatially to cartilage loss and impaired bone quality in human knee osteoarthritis. Osteoarthritis and Cartilage, 30(6), 896-907. DOI Scopus8 WoS1 Europe PMC2
2022	Lee, Y. -R., Briggs, M. T., Young, C., Condina, M. R., Kuliwaba, J. S., Anderson, P. H., & Hoffmann, P. (2022). Mass spectrometry imaging spatially identifies complex-type N-glycans as putative cartilage degradation markers in human knee osteoarthritis tissue. Analytical and Bioanalytical Chemistry, 414(26), 7597-7607. DOI Scopus8 WoS3 Europe PMC4
2021	Lee, Y. R., Briggs, M. T., Kuliwaba, J. S., Anderson, P. H., Condina, M. R., & Hoffmann, P. (2021). Gelatin-coated indium tin oxide slides improve human cartilage-bone tissue adherence and N-glycan signal intensity for mass spectrometry imaging. Analytical and Bioanalytical Chemistry, 413(10), 2675-2682. DOI Scopus12 WoS10 Europe PMC5
2021	Lee, Y. -R., Findlay, D. M., Muratovic, D., & Kuliwaba, J. S. (2021). Greater heterogeneity of the bone mineralisation density distribution and low bone matrix mineralisation characterise tibial subchondral bone marrow lesions in knee osteoarthritis patients. Bone, 149, 1-10. DOI Scopus9 WoS4 Europe PMC4
2020	Lee, Y., Findlay, D., Muratovic, D., Gill, T., & Kuliwaba, J. (2020). Raman microspectroscopy demonstrates reduced mineralization of subchondral bone marrow lesions in knee osteoarthritis patients. Bone Reports, 12, 100269-1-100269-9. DOI Scopus6 WoS4 Europe PMC2
2020	Lee, Y. R., Briggs, M. T., Condina, M. R., Puddy, H., Anderson, P. H., Hoffmann, P., & Kuliwaba, J. S. (2020). Mass spectrometry imaging as a potential tool to investigate human osteoarthritis at the tissue level. International Journal of Molecular Sciences, 21(17), 1-13. DOI Scopus10 WoS7 Europe PMC6
2019	Muratovic, D., Findlay, D. M., Cicuttini, F. M., Wluka, A. E., Lee, Y. R., Edwards, S., & Kuliwaba, J. S. (2019). Bone marrow lesions in knee osteoarthritis: regional differences in tibial subchondral bone microstructure and their association with cartilage degeneration. Osteoarthritis and Cartilage, 27(11), 1653-1662. DOI Scopus35 WoS20 Europe PMC20
2019	Zhu, S., Zhu, J., Zhen, G., Hu, Y., An, S., Li, Y., . . . Cao, X. (2019). Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain. Journal of Clinical Investigation, 129(3), 1076-1093. DOI Scopus271 WoS174 Europe PMC201
2018	Muratovic, D., Findlay, D., Cicuttini, F., Wluka, A., Lee, Y. -R., & Kuliwaba, J. (2018). Bone matrix microdamage and vascular changes characterize bone marrow lesions in the subchondral bone of knee osteoarthritis. Bone, 108, 193-201. DOI Scopus51 WoS35 Europe PMC25
2016	Muratovic, D., Cicuttini, F., Wluka, A., Findlay, D., Wang, Y., Otto, S., . . . Kuliwaba, J. (2016). Bone marrow lesions detected by specific combination of MRI sequences are associated with severity of osteochondral degeneration. Arthritis Research and Therapy, 18(1), 54-1-54-11. DOI Scopus52 WoS43 Europe PMC30
2016	Freeman, B., Kuliwaba, J., Jones, C., Shu, C., Colloca, C., Zarrinkalam, M., . . . Howell, S. (2016). Allogeneic mesenchymal precursor cells promote healing in postero-lateral annular lesions and improve indices of lumbar intervertebral disc degeneration in an ovine model. Spine, 41(17), 1331-1339. DOI Scopus44 WoS33 Europe PMC22
2016	Briggs, M., Kuliwaba, J., Muratovic, D., Everest-Dass, A., Packer, N., Findlay, D., & Hoffmann, P. (2016). MALDI mass spectrometry imaging of N-glycans on tibial cartilage and subchondral bone proteins in knee osteoarthritis. Proteomics, 16(11-12), 1736-1741. DOI Scopus42 WoS37 Europe PMC24
2016	Findlay, D., & Kuliwaba, J. (2016). Bone-cartilage crosstalk: a conversation for understanding osteoarthritis. Bone Research, 4(1), 1-12. DOI Scopus199 WoS182 Europe PMC111
2013	Mohan, G., Perilli, E., Parkinson, I., Humphries, J., Fazzalari, N., & Kuliwaba, J. (2013). Pre-emptive, early, and delayed alendronate treatment in a rat model of knee osteoarthritis: effect on subchondral trabecular bone microarchitecture and cartilage degradation of the tibia, bone/cartilage turnover, and joint discomfort. Osteoarthritis and Cartilage, 21(10), 1595-1604. DOI Scopus55 WoS50 Europe PMC37
2012	Brennan, O., Kuliwaba, J., Lee, T., Parkinson, I., Fazzalari, N., McNamara, L., & O'Brien, F. (2012). Temporal changes in bone composition, architecture, and strength following estrogen deficiency in osteoporosis. Calcified Tissue International, 91(6), 440-449. DOI Scopus31 WoS26 Europe PMC20
2012	Kumarasinghe, D., Sullivan, T., Kuliwaba, J., Fazzalari, N., & Atkins, G. (2012). Evidence for the dysregulated expression of TWIST1, TGFβ1 and SMAD3 in differentiating osteoblasts from primary hip osteoarthritis patients. Osteoarthritis and Cartilage, 20(11), 1357-1366. DOI Scopus29 WoS25 Europe PMC18
2012	Humphries, J., Kuliwaba, J., Gibson, R., & Fazzalari, N. (2012). In situ fatty acid profile of femoral cancellous subchondral bone in osteoarthritic and fragility fracture females: Implications for bone remodelling. Bone, 51(2), 218-223. DOI Scopus14 WoS11 Europe PMC9
2012	Zoehrer, R., Perilli, E., Kuliwaba, J., Shapter, J., Fazzalari, N., & Voelcker, N. (2012). Human bone material characterization: integrated imaging surface investigation of male fragility fractures. Osteoporosis International, 23(0004), 1297-1309. DOI Scopus22 WoS20 Europe PMC8
2012	Carpentier, V., Wong, J., Yeap, Y., Gan, C., Sutton-Smith, P., Badiei, A., . . . Kuliwaba, J. (2012). Increased proportion of hypermineralized osteocyte lacunae in osteoporotic and osteoarthritic human trabecular bone: implications for bone remodeling. Bone, 50(3), 688-694. DOI Scopus81 WoS70 Europe PMC45
2011	Kumarasinghe, D., Hopwood, B., Kuliwaba, J., Atkins, G., & Fazzalari, N. (2011). An update on primary hip osteoarthritis including altered Wnt and TGF-beta associated gene expression from the bony component of the disease. Rheumatology, 50(12), 2166-2175. DOI Scopus15 WoS14 Europe PMC13
2011	Bartold, P., Kuliwaba, J., Lee, V., Shah, S., Marino, V., & Fazzalari, N. (2011). Influence of surface roughness and shape on microdamage of the osseous surface adjacent to titanium dental implants. Clinical Oral Implants Research, 22(6), 613-618. DOI Scopus30 WoS26 Europe PMC18
2011	Mohan, G., Perilli, E., Kuliwaba, J., Humphries, J., Parkinson, I., & Fazzalari, N. (2011). Application of in vivo micro-computed tomography in the temporal characterisation of subchondral bone architecture in a rat model of low-dose monosodium iodoacetate-induced osteoarthritis. Arthritis Research & Therapy, 13(6), 1-14. DOI Scopus78 WoS71 Europe PMC55
2011	Humphries, J. M., Wilson, C. J., Morgan, D., Mercer, G., Kuliwaba, J. S., & Fazzalari, N. L. (2011). BIOMARKERS OF KNEE OSTEOARTHRITIS: CORRELATION WITH OUTERBRIDGE CLASSIFICATION. OSTEOARTHRITIS AND CARTILAGE, 19, S79-S80. DOI
2011	Mohan, G., Perilli, E., Kuliwaba, J., Parkinson, I., Humphries, J., & Fazzalari, N. (2011). CHARACTERISATION OF TEMPORAL SUBCHONDRAL BONE CHANGES IN A RAT MODEL OF LOW-DOSE MONOSODIUM IODOACETATE INDUCED OSTEOARTHRITIS: AN <i>IN VIVO</i> MICRO-CT STUDY. OSTEOARTHRITIS AND CARTILAGE, 19, S61-S62. DOI WoS1
2010	Kidd, L. J., Stephens, A. S., Kuliwaba, J. S., Fazzalari, N. L., Wu, A. C. K., & Forwood, M. R. (2010). Temporal pattern of gene expression and histology of stress fracture healing. Bone, 46(2), 369-378. DOI Scopus76 WoS67 Europe PMC51
2010	Kumarasinghe, D., Perilli, E., Tsangari, H., Truong, L., Kuliwaba, J., Hopwood, B., . . . Fazzalari, N. (2010). Critical molecular regulators, histomorphometric indices and their correlations in the trabecular bone in primary hip osteoarthritis. Osteoarthritis and Cartilage, 18(10), 1337-1344. DOI Scopus24 WoS23 Europe PMC17
2008	Fazzalari, N., Ma, B., Sutton-Smith, P., Kuliwaba, J., Phipps, R., Parkinson, I., & Badiei, A. (2008). Calcium density of bone correlates with trabecular bone architecture. Bone, 42(Suppl 1), S49-S50. DOI
2008	Chang, M., Raggatt, L., Alexander, K., Kuliwaba, J., Fazzalari, N., Schroder, K., . . . Pettit, A. (2008). Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo. Journal of Immunology, 181(2), 1232-1244. DOI Scopus568 WoS489 Europe PMC384
2007	Tsangari, H., Kuliwaba, J., & Fazzalari, N. (2007). Trabecular bone modeling and subcapital femoral fracture. The Journal of Musculoskeletal and Neuronal Interactions, 7(1), 69-73. Scopus5 Europe PMC2
2007	Kuliwaba, J. S., Sutton-Smith, P., & Fazzalari, N. L. (2007). Intrinsic bone quality in fragility hip fracture patients: Altered mineralisation and microdamage accumulation. CALCIFIED TISSUE INTERNATIONAL, 80, S44.
2006	Truong, L., Kuliwaba, J., Tsangari, H., & Fazzalari, N. (2006). Differential gene expression of bone anabolic factors and trabecular bone architectural changes in the proximal femoral shaft of primary hip osteoarthritis patients. Arthritis Research & Therapy, 8(6), 1-12. DOI Scopus52 WoS49 Europe PMC41
2006	Tsangari, H., Findlay, D., Zannettino, A., Pan, B., Kuliwaba, J., & Fazzalari, N. (2006). Evidence for reduced bone formation surface relative to bone resorption surface in female femoral fragility fracture patients. Bone, 39(6), 1226-1235. DOI Scopus19 WoS19 Europe PMC15
2005	Zarrinkalam, K., Kuliwaba, J., Martin, R., Blesing, M., & Fazzalari, N. (2005). New insights into the propagation of fatigue damage in cortical bone using confocal microscopy and chelating fluorochromes. European Journal of Morphology, 42(1-2), 81-90. DOI Scopus29 Europe PMC17
2005	Kuliwaba, J., Fazzalari, N., & Findlay, D. (2005). Stability of RNA isolated from human trabecular bone at post-mortem and surgery. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1740(1), 1-11. DOI Scopus36 WoS32 Europe PMC20
2005	Hopwood, B., Gronthos, S., Kuliwaba, J., Robey, P., Findlay, D., & Fazzalari, N. (2005). Identification of differentially expressed genes between osteoarthritic and normal trabecular bone from the intertrochanteric region of the proximal femur using cDNA microarray analysis. Bone, 36(4), 635-644. DOI Scopus21 WoS18 Europe PMC17
2005	De Leo, A., Wheeler, D., Lefevre, C., Cheng, J., Hope, R., Kuliwaba, J., . . . Graves, J. (2005). Sequencing and mapping hemoglobin gene clusters in the Australian model dasyurid marsupial Sminthopsis macroura. Cytogenetic and Genome Research, 108(4), 333-341. DOI Scopus14 WoS14 Europe PMC12
2004	Tsangari, H., Findlay, D., Kuliwaba, J., Atkins, G., & Fazzalari, N. (2004). Increased expression of IL-6 and RANK mRNA in human trabecular bone from fragility fracture of the femoral neck. Bone, 35(1), 334-342. DOI Scopus57 WoS54 Europe PMC39
2002	Fazzalari, N., Kuliwaba, J., & Forwood, M. (2002). Cancellous bone microdamage in the proximal femur: Influence of age and osteoarthritis on damage morphology and regional distribution. Bone, 31(6), 697-702. DOI Scopus58 WoS52 Europe PMC36
2001	Fazzalari, N., Kuliwaba, J., Atkins, G., Forwood, M., & Findlay, D. (2001). The ratio of messenger RNA levels of receptor activator of nuclear factor kB ligand to osteoprotegerin correlates with bone remodeling indices in normal human cancellous bone but not in osteoarthritis. Journal of Bone and Mineral Research, 16(6), 1015-1027. DOI Scopus118 WoS101 Europe PMC81
2001	Fazzalari, N., Kuliwaba, J., Atkins, G., Forwood, M., & Findlay, D. (2001). Osteoclast differentiation factor is dominant in controlling the extent of bone resorption. Bone, 28(5), S160. DOI
2001	Fazzalari, N., Kuliwaba, J., Findlay, D., & Forwood, M. (2001). Microdamage distribution and altered messenger RNA gene expression in the proximal femur. BONE, 28(5), S105-S106. WoS1
2001	Kuliwaba, J. S., Findlay, D. M., Atkins, G. J., Forwood, M. R., & Fazzalari, N. L. (2001). Gene expression in human cancellous bone is similar between skeletal sites.. JOURNAL OF BONE AND MINERAL RESEARCH, 16, S327.
2000	Kitahama, S., Gibson, M., Hatzinikolas, G., Hay, S., Kuliwaba, J., Evdokiou, A., . . . Findlay, D. (2000). Expression of fibrillins and other microfibril-associated proteins in human bone and osteoblast-like cells. Bone, 27(1), 61-67. DOI Scopus57 WoS53 Europe PMC34
2000	Findlay, D., Atkins, G., Forwood, M., Kuliwaba, J., & Fazzalari, N. (2000). Enhanced expression of osteocalcin mRNA in human osteoarthritic trabecular bone of the proximal femur is associated with decreased expression of interleukin-6 and interleukin-11 mRNA. Journal of Bone and Mineral Research, 15(2), 332-341. DOI Scopus46 WoS43 Europe PMC36

Conference Papers

Year	Citation
2019	Kuliwaba, J. S., Lee, Y. -R., Muratovic, D., Gill, T. K., & Findlay, D. M. (2019). BIOCHEMICAL PROFILING OF BONE MARROW LESIONS IN KNEE OSTEOARTHRITIS PATIENTS: ALTERED MINERALIZATION OF THE SUBCHONDRAL BONE MATRIX. In OSTEOARTHRITIS AND CARTILAGE Vol. 27 (pp. S111). Toronto, CANADA: ELSEVIER SCI LTD. DOI WoS1
2018	Kuliwaba, J., Mulaibrahimovic, A., Freeman, B., Kantar, K., Brown, P., & Osti, O. (2018). CHARACTERISATION OF BONE MARROW PATHOLOGIES ACROSS THE SPECTRUM OF MODIC CHANGES IN THE HUMAN LUMBAR SPINE. In INTERNAL MEDICINE JOURNAL Vol. 48 (pp. 6-7). WILEY.
2018	Kuliwaba, J., Lee, Y. -R., Muratovic, D., & Findlay, D. (2018). RAMAN SPECTRAL IMAGING OF BONE MARROW LESIONS IN KNEE OSTEOARTHRITIS: ALTERED BIOCHEMICAL COMPOSITION OF THE SUBCHONDRAL BONE MATRIX. In INTERNAL MEDICINE JOURNAL Vol. 48 (pp. 8). WILEY.
2018	Kuliwaba, J., Lee, Y. -R., Muratovic, D., & Findlay, D. (2018). Biochemical Profiling of MRI-detected Bone Marrow Lesions in Knee Osteoarthritis Patients: Altered Mineralization of the Subchondral Bone Matrix. In JOURNAL OF BONE AND MINERAL RESEARCH Vol. 33 (pp. 247). Montreal, CANADA: WILEY.
2015	Muratovic, D., Cicuttini, F. M., Wluka, A., Wang, Y., Findlay, D., Otto, S., . . . Kuliwaba, J. (2015). BONE MARROW LESIONS DETECTED BY TWO MRI SEQUENCES ASSOCIATE WITH SEVERITY OF KNEE OSTEOARTHRITIS. In INTERNAL MEDICINE JOURNAL Vol. 45 (pp. 6). WILEY-BLACKWELL.
2015	Muratovic, D., Cicuttini, F. M., Wluka, A., Wang, Y., Findlay, D. M., Otto, S., . . . Kuliwaba, J. S. (2015). BONE MARROW LESIONS DETECTED BY DIFFERENT MAGNETIC RESONANCE SEQUENCES AS POTENTIAL BIOMARKERS FOR KNEE OSTEOARTHRITIS: COMPREHENSIVE TISSUE LEVEL ANALYSIS. In OSTEOARTHRITIS AND CARTILAGE Vol. 23 (pp. A303-A305). Seattle, WA: ELSEVIER SCI LTD. DOI WoS1
2014	Kuliwaba, J., Lee, Y., Naas, S., Muratovic, D., Humphries, J., & Findlay, D. (2014). THE PATHOPHYSIOLOGY OF SUBCHONDRAL BONE IN POSTMENOPAUSAL KNEE OSTEOARTHRITIS: MICRODAMAGE ACCUMULATION, OSTEOCYTE CELL DEFICIENCY AND BONE MARROW HYPERVASCULARITY. In INTERNAL MEDICINE JOURNAL Vol. 44 (pp. 1). WILEY-BLACKWELL. DOI
2011	Mohan, G., Perilli, E., Kuliwaba, J., Humphries, J., Parkinson, I., & Fazzalari, N. (2011). ALENDRONATE TREATMENT REDUCES TIBIAL SUBCHONDRAL BONE DAMAGE IN EARLY-STAGE OSTEOARTHRITIS: AN IN VIVO MICROCT STUDY IN A RODENT MODEL. In OSTEOPOROSIS INTERNATIONAL Vol. 22 (pp. S579). Gold Coast, AUSTRALIA: SPRINGER LONDON LTD.
2010	Kuliwaba, V., Truong, L., Codrington, J., & Fazzalari, N. (2010). Integrity of the osteocyte bone cell network in osteoporotic fracture: implications for mechanical load adaptation. In Proceedings of the 6th Australasian Congress on Applied Mechanics Vol. 10 (pp. 1-7). www: IOP Publishing. DOI
2009	Kuliwaba, J. S., Tsangari, H., Davies, R., & Fazzalari, N. L. (2009). Bone microdamage accumulates in the central region of the human lumbar vertebra. In BONE Vol. 44 (pp. S151). Sydney, AUSTRALIA: ELSEVIER SCIENCE INC. DOI WoS1
2009	Codrington, J., Kuliwaba, J., Zarrinkalam, K., & Fazzalari, N. (2009). A study of cortical bone microdamage and crack morphology utilising confocal microscopy and sequential labelling. In Proceedings of the International Conference on CRACK PATHS (CP2009) (pp. 679-686). Italy: ESIS.
2007	Sutton-Smith, P., Fazzalari, N., Kuliwaba, J., Beard, H., & Ma, B. (2007). Back-scattered electron imaging of bone mineralization in osteoarthritis. In JOURNAL OF BONE AND MINERAL RESEARCH Vol. 22 (pp. S258-S259). Honolulu, HI: AMER SOC BONE & MINERAL RES.
2007	Kidd, L. J., Stephens, A., Kuliwaba, J. S., Fazzalari, N. L., & Forwood, M. R. (2007). Temporal pattern of gene expression and histology of stress fracture healing in the rat ulna-loading model. In JOURNAL OF BONE AND MINERAL RESEARCH Vol. 22 (pp. S69). Honolulu, HI: AMER SOC BONE & MINERAL RES.
2007	Raggatt, L. J., Chang, M. K., Alexander, K. A., Kuliwaba, J. S., Fazzalari, N. L., Hume, D. A., & Pettit, A. R. (2007). Osteal macrophages: Novel regulators of bone formation. In JOURNAL OF BONE AND MINERAL RESEARCH Vol. 22 (pp. S53). Honolulu, HI: AMER SOC BONE & MINERAL RES.
2007	Fazzalari, N. L., Ma, B., Sutton-Smith, P., Kuliwaba, J. S., Phipps, R., Parkinson, I. H., & Badiei, A. (2007). Calcium density of bone correlates with trabecular bone architecture. In JOURNAL OF BONE AND MINERAL RESEARCH Vol. 22 (pp. S226). Honolulu, HI: AMER SOC BONE & MINERAL RES.
2005	Kuliwaba, J. S., Cowan, J. P., Pan, N., & Fazzalari, N. L. (2005). Reduced osteocyte density at the iliac crest in fragility hip fracture patients. In BONE Vol. 36 (pp. S381). Geneva, SWITZERLAND: ELSEVIER SCIENCE INC.
2003	Dassios, H., Findlay, D. M., Kuliwaba, J. S., Atkins, G. J., & Fazzalari, N. L. (2003). Enhanced gene expression of osteoclastogenic factors in human osteoporotic trabecular bone. In BONE Vol. 32 (pp. S149). OSAKA, JAPAN: ELSEVIER SCIENCE INC.
2001	Atkins, G., Kuliwaba, J., Findlay, D., Forwood, M., & Fazzalari, N. (2001). Differential Gene Expression in the Human Bone Microenvironment of the Hip; Comparison Between Control and Osteoarthritis.. In Journal of Bone and Joint Surgery (Br.) Vol. 84-B (pp. 235). Adelaide, South Australia: The British Editorial Society of Bone and Joint Surgery.

Conference Items

Year	Citation
2021	Muratovic, D., Findlay, D. M., Masri, H. H., Stapledon, C. J., Lee, Y., Cao, X., . . . Kuliwaba, J. S. (2021). ELEVATED LEVELS OF ACTIVE TRANSFORMING GROWTH FACTOR beta 1 IN THE SUBCHONDRAL BONE RELATE SPATIALLY TO IMPAIRED BONE QUALITY AND CARTILAGE LOSS IN HUMAN KNEE OSTEOARTHRITIS. Poster session presented at the meeting of OSTEOARTHRITIS AND CARTILAGE. ELSEVIER SCI LTD. DOI
2021	Lee, Y. R. O., Briggs, M., Kuliwaba, J., Hoffmann, P., Muratovic, D., & Anderson, P. (2021). MASS SPECTROMETRY TISSUE IMAGING IDENTIFIES COMPLEX/HYBRID-TYPE N-GLYCANS AS PUTATIVE NOVEL CARTILAGE DEGRADATION MARKERS FOR HUMAN KNEE OSTEOARTHRITIS. Poster session presented at the meeting of INTERNAL MEDICINE JOURNAL. WILEY.
2021	Muratovic, D., Findlay, D., Lee, R. Y., Quarrington, R., & Kuliwaba, J. (2021). ELEVATED LEVELS OF ACTIVE TRANSFORMING GROWTH FACTOR B1 IN THE SUBCHONDRAL BONE RELATE SPATIALLY TO THE SEVERITY OF HUMAN KNEE OSTEOARTHRITIS. Poster session presented at the meeting of INTERNAL MEDICINE JOURNAL. WILEY.
2017	Jones, C. F., Robertson, W. S. P., Callary, S., Mulaibrahimovic, A., Kuliwaba, J., Gunzburg, R., . . . Freeman, B. J. (2017). Radiographic, Mechanical and Histological Evaluation of Fusion in an Ovine Model: Peek Interbody Cages With and Without a Porous Titanium Alloy Coating. Poster session presented at the meeting of XXVI Congress of the International Society of Biomechanics. Brisbane, Australia.
2017	Jones, C. F., Robertson, W. S. P., Callary, S., mulaibrahimovic., Kuliwaba., Gunzburg, R., . . . Freeman. (2017). Radiographic, mechanical and histological evaluation of fusion using PEEK interbody cages with and without a porous titanium alloy coating, in an ovine model. Poster session presented at the meeting of ANZORS-RSA Joint Conference. Adelaide.
2017	Jones, C. F., Robertson, W. S. P., Callary, S., Mulaibrahimovic, A., Kuliwaba, J., Gunzburg, R., . . . Freeman, B. J. C. (2017). Evaluation of fusion with a porous titanium alloy coated peek interbody cage in an ovine model. Poster session presented at the meeting of Spine Society of Australia 28th Annual Scientific Meeting. Hobart.
2015	Freeman, B., Kuliwaba, J., Zarrinkalam, M., Jones, C., Shu, C., Colloca, C., . . . Howell, S. (2015). ALLOGENEIC MESENCHYMAL STEM CELLS IMPROVE INDICES OF LUMBAR INTERVERTEBRAL DISC DEGENERATION WITHOUT SITE SPECIFICITY OF INJECTION IN AN OVINE MODEL. Poster session presented at the meeting of OSTEOARTHRITIS AND CARTILAGE. Seattle, WA: ELSEVIER SCI LTD. DOI WoS1
2014	Muratovic, D., Cicuttini, F. M., Wluka, A., Wang, Y., Findlay, D., Otto, S., . . . Kuliwaba, J. (2014). BONE MARROW LESIONS IN KNEE OSTEOARTHRITIS. Poster session presented at the meeting of INTERNAL MEDICINE JOURNAL. WILEY-BLACKWELL.
2014	Kuliwaba, J. S., Lee, Y. -R., Naas, S., Muratovic, D., Humphries, J. M., & Findlay, D. M. (2014). THE PATHOPHYSIOLOGY OF SUBCHONDRAL CANCELLOUS BONE IN POSTMENOPAUSAL KNEE OSTEOARTHRITIS: DIFFUSE MICRODAMAGE ACCUMULATION, OSTEOCYTE CELL DEFICIENCY AND BONE MARROW HYPERVASCULARITY. Poster session presented at the meeting of OSTEOARTHRITIS AND CARTILAGE. Paris, FRANCE: ELSEVIER SCI LTD. DOI
2013	Carpentier, V., Tsangari, H., Fazzalari, N., & Kuliwaba, J. (2013). Regional Heterogeneity of Trabecular Bone Microcrack Density in Association with Trabecular Microarchitecture and Bone Resorption in Whole Human Lumbar Vertebrae. Poster session presented at the meeting of JOURNAL OF BONE AND MINERAL RESEARCH. Baltimore, MD: WILEY-BLACKWELL.
2008	Papadopoulos, A., Truong, L., Kuliwaba, J. S., & Fazzalari, N. L. (2008). Immunohistochemical localisation of sclerostin in human trabecular bone from fragility hip fracture patients. Poster session presented at the meeting of 30th Annual Meeting of the American Society for Bone and Mineral Research, as published in Journal of Bone and Mineral Research. Montreal, Canada: Wiley. DOI

National Health and Medical Research Council, 2018-2020, Project Grant, AUD $634,359, Transforming Growth Factor Beta as a causal factor in human osteoarthritis. CIs: Findlay DM, Cao X, Kuliwaba JS, Gill T, Solomon LB.

Arthritis Australia, 2016-2017, Project Grant, AUD $30,000, Molecular profiling of bone marrow lesions in osteoarthritis. CIs: Kuliwaba JS, Findlay DM, Hoffmann P.

National Health and Medical Research Council, 2013-2016, Project Grant, AUD $451,683, Targeting bone marrow lesions to find interventions in the progression of osteoarthritis. CIs: Findlay DM, Wluka AE, Kuliwaba JS, Taylor DJ.

National Health and Medical Research Council, 2008-2010, Project Grant, AUD $434,498, Vertebral body strength: contribution of bone mass, bone structure and material properties. CIs: Fazzalari NL, Kuliwaba JS, Parkinson IH, Sutton-Smith P.

National Health and Medical Research Council, 2006-2008, Project Grant, AUD $438,125, Intrinsic bone qualities in fragility fracture patients: mass, microarchitecture, mineralization and damage accumulation. CIs: Fazzalari NL, Kuliwaba JS.

National Health and Medical Research Council, 2006-2008, Project Grant, AUD $399,750, Influence of anti-inflammatory treatments on healing of stress fractures. CIs: Forwood MR, Fazzalari NL, Kuliwaba JS.

Past Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2013 - 2018	Principal Supervisor	Bone Marrow Lesions in Progression of Knee Osteoarthritis	Doctor of Philosophy	Doctorate	Full Time	Dr Dzenita Muratovic
2008 - 2012	Co-Supervisor	Mechanisms of Osteoarthritis: Interrelationships between Bone and Cartilage	Doctor of Philosophy	Doctorate	Full Time	Miss Geetha Mohan

Other Supervision Activities

Date	Role	Research Topic	Location	Program	Supervision Type	Student Load	Student Name
2019 - ongoing	External Supervisor	Discovery of knee osteoarthritis-associated biomarkers in different types of human biospecimens using proteomic-based strategies	University of South Australia	Doctor of Philosophy	Doctorate	Full Time	Yea Rin (Olivia) Lee

Position: Senior Research Funding Officer (Pre-Award)
Phone: 83136244
Email: julia.kuliwaba@adelaide.edu.au
Campus: North Terrace
Building: 44-60 Rundle Mall - Rundle Mall Plaza, floor Level Three
Org Unit: Research Services

Dr Julia Kuliwaba

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Past Higher Degree by Research Supervision (University of Adelaide)

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