Jan Kazenwadel

Dr Jan Kazenwadel

Research Fellow

Centre for Cancer Biology

College of Health


Year Citation
2024 Panara, V., Yu, H., Peng, D., Staxäng, K., Hodik, M., Filipek-Gorniok, B., . . . Koltowska, K. (2024). Multiple cis-regulatory elements control prox1a expression in distinct lymphatic vascular beds. Development, 151(9), dev202525-1-dev202525-14.
DOI Scopus5 WoS5 Europe PMC6
2024 Williamson, A. E., Liyanage, S., Hassanshahi, M., Dona, M. S. I., Toledo-Flores, D., Tran, D. X. A., . . . Psaltis, P. J. (2024). Discovery of an embryonically derived bipotent population of endothelial-macrophage progenitor cells in postnatal aorta. Nature Communications, 15(1), 7097-1-7097-21.
DOI Scopus6 WoS8 Europe PMC6
2023 Kazenwadel, J., Venugopal, P., Oszmiana, A., Toubia, J., Arriola-Martinez, L., Panara, V., . . . Harvey, N. L. (2023). A Prox1 enhancer represses haematopoiesis in the lymphatic vasculature. Nature, 614(7947), 343-348.
DOI Scopus30 WoS30 Europe PMC29
2023 Chiang, I. K. N., Graus, M. S., Kirschnick, N., Davidson, T., Luu, W., Harwood, R., . . . Francois, M. (2023). The blood vasculature instructs lymphatic patterning in a SOX7-dependent manner. EMBO Journal, 42(5, article no. e109032), 1-23.
DOI Scopus8 WoS8 Europe PMC9
2022 Byrne, A. B., Brouillard, P., Sutton, D. L., Kazenwadel, J., Montazaribarforoushi, S., Secker, G. A., . . . Harvey, N. L. (2022). Pathogenic variants in MDFIC cause recessive central conducting lymphatic anomaly with lymphedema. Science Translational Medicine, 14(634), eabm4869-1-eabm4869-15.
DOI Scopus38 WoS29 Europe PMC31
2020 Betterman, K. L., Sutton, D. L., Secker, G. A., Kazenwadel, J., Oszmiana, A., Lim, L., . . . Harvey, N. L. (2020). Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow. Journal of Clinical Investigation, 130(6), 3315-3328.
DOI Scopus52 WoS46 Europe PMC45
2018 Frye, M., Taddei, A., Dierkes, C., Martinez-Corral, I., Fielden, M., Ortsäter, H., . . . Mäkinen, T. (2018). Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program. Nature Communications, 9(1), 1511-1-1511-16.
DOI Scopus135 WoS127 Europe PMC114
2018 Kazenwadel, J., & Harvey, N. L. (2018). Lymphatic endothelial progenitor cells: origins and roles in lymphangiogenesis. Current Opinion in Immunology, 53, 81-87.
DOI Scopus24 WoS21 Europe PMC22
2016 Kazenwadel, J., & Harvey, N. (2016). Morphogenesis of the lymphatic vasculature: a focus on new progenitors and cellular mechanisms important for constructing lymphatic vessels. Developmental Dynamics, 245(3), 209-219.
DOI Scopus31 WoS29 Europe PMC23
2015 Kazenwadel, J., Betterman, K., Chong, C., Stokes, P., Lee, Y., Secker, G., . . . Harvey, N. (2015). GATA2 is required for lymphatic vessel valve development and maintenance. Journal of Clinical Investigation, 125(8), 2979-2994.
DOI Scopus193 WoS175 Europe PMC156
2014 Kartopawiro, J., Bower, N., Karnezis, T., Kazenwadel, J., Betterman, K., Lesieur, E., . . . Hogan, B. (2014). Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development. Human Molecular Genetics, 23(5), 1286-1297.
DOI Scopus27 WoS26 Europe PMC27
2014 Bowles, J., Secker, G., Nguyen, C., Kazenwadel, J., Truong, V., Frampton, E., . . . Francois, M. (2014). Control of retinoid levels by CYP26B1 is important for lymphatic vascular development in the mouse embryo. Developmental Biology, 386(1), 25-33.
DOI Scopus38 WoS34 Europe PMC35
2013 Paterson, E., Kazenwadel, J., Bert, A., Khew-Goodall, Y., Ruszkiewicz, A., & Goodall, G. (2013). Down-regulation of the miRNA-200 family at the invasive front of colorectal cancers with degraded basement membrane indicates EMT is involved in cancer progression. Neoplasia, 15(2), 180-191.
DOI Scopus150 WoS140 Europe PMC127
2012 Kazenwadel, J., Secker, G., Betterman, K., & Harvey, N. (2012). In Vitro assays using primary embryonic mouse lymphatic endothelial cells uncover key roles for FGFR1 signalling in lymphangiogenesis. PLoS One, 7(7), 1-12.
DOI Scopus38 WoS35 Europe PMC38
2012 Kazenwadel, J., Secker, G., Liu, Y., Rosenfeld, J., Wildin, R., Cuellar-Rodriguez, J., . . . Harvey, N. (2012). Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature. Blood, 119(5), 1283-1291.
DOI Scopus245 WoS217 Europe PMC204
2011 Bastian, I., Tam Tam, S., Zhou, X., Kazenwadel, J., Van Der Hoek, M., Michael, M., . . . Haberberger, R. (2011). Differential expression of microRNA-1 in dorsal root ganglion neurons. Histochemistry and Cell Biology, 135(1), 37-45.
DOI Scopus17 WoS16 Europe PMC17
2010 Kazenwadel, J., Michael, M., & Harvey, N. (2010). Prox1 expression is negatively regulated by miR-181 in endothelial cells. Blood, 116(13), 2395-2401.
DOI Scopus140 WoS138 Europe PMC130
2002 Dziadek, M., Kazenwadel, J. S., A. Hendrey, J., Pan, T. C., Zhang, R. Z., & Chu, M. L. (2002). Alternative splicing of transcripts for the alpha3 chain of mouse collagen VI: Identification of an abundant isoform lacking domains N7-N10 in mouse and human. Matrix Biology, 21(3), 227-241.
DOI Scopus15 WoS13 Europe PMC14
2001 Williams, R., Manji, S., Parker, N., Hancock, M., van Stekelenburg, L., Eid, J., . . . Dziadek, M. (2001). Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins. Biochemical Journal, 357(Part 3), 673-685.
DOI Scopus283 WoS264 Europe PMC204
1994 James, R., Erler, T., & Kazenwadel, J. (1994). Structure of the Murine Homeobox Gene cdx-2: Expression in Embryonic and Adult Intestinal Epithelium. Journal of Biological Chemistry, 269(21), 15229-15237.
DOI Scopus270 WoS270 Europe PMC198
1993 Hu, Y., Kazenwadel, J., & James, R. (1993). Isolation and characterization of the murine homeobox gene Cdx-1: Regulation of expression in intestinal epithelial cells. Journal of Biological Chemistry, 268(36), 27214-27225.
DOI Scopus60 WoS64 Europe PMC46
1991 James, R., & Kazenwadel, J. (1991). Homeobox gene expression in the intestinal epithelium of adult mice. Journal of Biological Chemistry, 266(5), 3246-3251.
DOI Scopus203 WoS206 Europe PMC162
1989 James, R., & Kazenwadel, J. (1989). T-cell nuclei contain a protein that binds upstream of the murine granulocyte-macrophage colony-stimulating factor gene. Proceedings of the National Academy of Sciences of the United States of America, 86(19), 7392-7396.
DOI Scopus5 WoS7 Europe PMC2

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