Dr Nan Hao

Nan Hao
Synthetic Biology Future Science Fellow
School of Biological Sciences
Faculty of Sciences

My research interest lies in the broad fields of Synthetic Biology with the aim to combine biochemical studies with mathematical modeling to better understand the “design” features of the genome. This knowledge will inform the design of next generation synthetic platforms for biotechnology and bioremediation.

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External Profiles

Dr Nan Hao

My research interest lies in the broad fields of Synthetic Biology with the aim to combine biochemical studies with mathematical modeling to better understand the “design” features of the genome. This knowledge will inform the design of next generation synthetic platforms for biotechnology and bioremediation.

I am a Synthetic Biology Future Science Fellow based in the School of Biological Sciences. My research aims to advance fundamental knowledge and addresses widespread but poorly understood processes in gene transcription such as transcriptional interference, transcriptional roadblocking, feedback control and DNA looping, all of which are likely to be highly significant for regulation of gene expression. In addition, one important aspect of my research is to apply mathematical thinking to understand the ‘design’ features of the genome.

Appointments

Date Position Institution name
2017 Synthetic Biology Future Science Fellow (Level B) University of Adelaide and CSIRO joint appointment
2017 - 2017 ARC DECRA Fellow (Level B) University of Adelaide, Adelaide
2015 - 2016 ARC DECRA Fellow (Level A) University of Adelaide, Adelaide
2012 - 2014 Postdoc Research Fellow (Level A) University of Adelaide, Adelaide
2007 - 2008 Research Assistant University of Adelaide, Adelaide
2006 - 2007 Research Assistant University of Adelaide, Adelaide

Awards and Achievements

Date Type Title Institution Name Amount
2017 Achievement Finalist ASBMB Adelaide Protein Group (APG) ECR Award
2017 Invitation Invited Seminar Presentation Epigenetics Consortium of South Australia and Adelaide RNA Special Interest Group Seminar
2017 Invitation Invited Pitch US Department of Defence Representative
2016 Award Best presentation/poster in the ECR category OCE Cutting Edge Conference in Synthetic Biology A$ 200
2015 Invitation Invited Speaker School of Biological Sciences Inaugural Research Day
2015 Fellowship ASBMB travel fellowship ASBMB A$ 3000
2012 Award Poster Award ASBMB ComBio conference A$ 200
2012 Research Award Postgraduate Academic Achievement Award The University of Adelaide A$ 500
2012 Award Writing up Award The University of Adelaide A$ 3000
2011 Award Poster prize ASBMB Adelaide Protein Group A$ 200
2011 Award Chinese government award for outstanding self-financed students abroad China Scholarship Council US$ 6000
2010 Achievement Finalist ASBMB Adelaide Protein Group Student Event
2008 Scholarship Adelaide Graduate Fee Scholarship - PhD scholarship The University of Adelaide
2007 Award The Brian & Heather Forster Prize in Biochemistry - Top Honours The University of Adelaide
2005 Scholarship Summer Vacation Scholarship The University of Adelaide

Language Competencies

Language Competency
Chinese (Mandarin) Can read, write, speak, understand spoken and peer review
English Can read, write, speak, understand spoken and peer review

Education

Date Institution name Country Title
2008 - 2012 The University of Adelaide Australia PhD in Biochemistry
2007 - 2007 The University of Adelaide Australia B. Sc. (Honours, First class)
2004 - 2006 The University of Adelaide Australia B. Sc. (Biomedical Science)

Postgraduate Training

Date Title Institution Country
2015 - 2015 2nd International Summer School on Synthetic and Systems Biology University of Catania Italy

Research Interests

Biochemistry & Molecular Biology, Synthetic Biology

Journals

Year Citation
2017 Hao, N., Shearwin, K. & Dodd, I. (2017). Programmable DNA looping using engineered bivalent dCas9 complexes. Nature Communications, 8, 1, -.
10.1038/s41467-017-01873-x
2017 Hao, N., Sneppen, K., Shearwin, K. & Dodd, I. (2017). Efficient chromosomal-scale DNA looping in Escherichia coli using multiple DNA-looping elements. Nucleic Acids Research, 45, 9, 5074-5085.
10.1093/nar/gkx069
2017 Hao, N. & Shearwin, K. (2017). Hidden Secrets of Sigma54 Promoters Revealed. Trends in Biochemical Sciences, 42, 12, 931-932.
10.1016/j.tibs.2017.10.005
2017 Hao, N., Palmer, A., Dodd, I. & Shearwin, K. (2017). Directing traffic on DNA - How transcription factors relieve or induce transcriptional interference. Transcription, 8, 2, 120-125.
10.1080/21541264.2017.1285851
2016 Hao, N., Palmer, A., Ahlgren-Berg, A., Shearwin, K. & Dodd, I. (2016). The role of repressor kinetics in relief of transcriptional interference between convergent promoters. Nucleic Acids Research, 44, 14, 6625-6638.
10.1093/nar/gkw600
2016 Silginer, M., Burghardt, I., Gramatzki, D., Bunse, L., Leske, H., Rushing, E. ... Roth, P. (2016). The aryl hydrocarbon receptor links integrin signaling to the TGF-β pathway. Oncogene, 35, 25, 3260-3271.
10.1038/onc.2015.387
2014 Hao, N., Krishna, S., Ahlgren-Berg, A., Cutts, E., Shearwin, K. & Dodd, I. (2014). Road rules for traffic on DNA - systematic analysis of transcriptional roadblocking in vivo. Nucleic Acids Research, 42, 14, 8861-8872.
10.1093/nar/gku627
2013 Hao, N. & Whitelaw, M. (2013). The emerging roles of AhR in physiology and immunity. Biochemical Pharmacology, 86, 5, 561-570.
10.1016/j.bcp.2013.07.004
2013 Hao, N., Bhakti, V., Peet, D. & Whitelaw, M. (2013). Reciprocal regulation of the basic helix-loop-helix/Per-Arnt-Sim partner proteins, Arnt and Arnt2, during neuronal differentiation. Nucleic Acids Research, 41, 11, 5626-5638.
10.1093/nar/gkt206
2012 Hao, N., Lee, K., Furness, S., Bosdotter, C., Poellinger, L. & Whitelaw, M. (2012). Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signaling. Molecular Pharmacology, 82, 6, 1082-1093.
10.1124/mol.112.078873
2011 Hao, N., Whitelaw, M. L., Shearwin, K. E., Dodd, I. B. & Chapman-Smith, A. (2011). Identification of residues in the N-terminal PAS domains important for dimerization of Arnt and AhR. Nucleic Acids Research, 39, 9, 3695-3709.
10.1093/nar/gkq1336
2010 Whelan, F., Hao, N., Furness, S., Whitelaw, M. & Chapman-Smith, A. (2010). Amino acid substitutions in the aryl hydrocarbon receptor ligand binding domain reveal YH439 as an atypical AhR activator. Molecular Pharmacology, 77, 6, 1037-1046.
10.1124/mol.109.062927

Conference Papers

Year Citation
2017 Hao, N., Shearwin, K. E. & Dodd, I. (2017). Understanding and Manipulating Chromosomal-Scale DNA Looping in Escherichia coli. Synthetic Biology: Engineering, Evolution & Design (SEED). Vancouver, Canada.

Conference Items

Year Citation
2017 Hao, N. (2017). Programmable DNA looping using engineered bivalent dCas9 complexes. ASBMB ComBio conference. Adelaide.
2017 Hao, N. (2017). Programmable DNA looping using engineered bivalent dCas9 complexes. Synthetic Biology Australasia Conference. Sydney.
2017 Hao, N., Priest, D., Dodd, I. & Shearwin, K. (2017). Programmable DNA looping in vivo. Australia-China Symposium on Synthetic Biology. Brisbane.
2016 Hao, N., Shearwin, K. & Dodd, I. (2016). Understand DNA looping in vivo - a synthetic biology approach. OCE Cutting Edge Conference in Synthetic Biology. Canberra.
2016 Hao, N., Shearwin, K. & Dodd, I. (2016). Road Rules for Traffic on DNA: Gene Regulation by Encounters between Transcribing RNA Polymerases and DNA-bound Proteins. Synthetic Biology: Engineering, Evolution & Design (SEED). Chicago, USA.
2015 Hao, N., Krishna, S., Shearwin, K. & Dodd, I. (2015). Road Rules for Traffic on DNA: Gene Regulation by Encounters between Transcribing RNA Polymerases and DNA-bound Proteins. 2nd International Synthetic & Systems Biology Summer School. Taormina - Sicily, Italy.
2015 Hao, N. (2015). Understanding and manipulating long-range DNA looping in vivo. ASBMB ComBio conference. Melbourne.
2014 Hao, N. (2014). Road Rules for Traffic on DNA: Gene Regulation by Encounters between Transcribing RNA Polymerases and DNA-bound Proteins. The 13th Asian Conference on Transcription. Melbourne.
2012 Hao, N., Shearwin, K., Dodd, I., Whitelaw, M. & Chapman-Smith, A. (2012). Reverse Bacterial Two Hybrid: A New Tool for Studying Dimeric Protein Interactions. ASBMB ComBio conference. Adelaide.
2009 Hao, N., Shearwin, , Dodd, I., Whitelaw, M. & Chapman-Smith, A. (2009). Reverse Bacterial two Hybrid (RevB2H) method for studying protein-protein interactions. Network in Genes and Environment in Development (NGED) Forum. Palm Cove, Queensland.
2009 Hao, N., Shearwin, K., Dodd, I., Whitelaw, M. & Chapman-smith, A. (2009). A novel Reverse Bacterial two Hybrid (RevB2H) method for studying protein-protein interactions and screening for potential therapeutics. Australian Society for Medical Research (ASMR) SA Scientific Meeting. Adelaide.

Theses

Year Citation
2012 Hao, N.; (2012); Regulation of Eukaryotic Transcription by bHLH/PAS Transcription Factors AhR and Arnt;
2007 Hao, N.; (2007); Searching for HIF-1α/Arnt PAS Domain Interacting Proteins;

Internet Publications

Year Citation
2015 Hao, N.; (2015); Science Under the Volcano - Australian Biochemist Magazine;
Current Funding

2018-2019             Dr. Nan Hao, A/Prof. Keith Shearwin, Dr. Carol Hartley, Dr. Lawrence Lee and Dr. Colin Scott, Nanomachine v2.0. CSIRO SynBio FSP Pitch                                      Award, $10,000

2017-2020             Dr. Nan Hao, Developing orthogonal Cas/anti-Cas pairs as building blocks for genetic circuit design. CSIRO Future Science Fellowship in                                           Synthetic Biology, $505,000

2018-2018             Dr. Mark Tizard, Dr. Caitlin Cooper, Dr. Brendan Kidd, Dr. Nan Hao, Prof. Rob CaponLogic Gate Control for Biodiversity Protection. CSIRO                                       SynBio FSP Pitch Award, $10,000 

2016-2018             Dr. Ian Dodd, A/Prof. Keith Shearwin, Prof. Kim Sneppen, and Dr. Nan Hao, Understanding and manipulating long-range DNA looping in gene                                     regulation. NHMRC project grant (APP1100651), $351,025  

Previous Funding

2015-2017             Dr. Nan Hao, Traffic on DNA: interplay between RNA polymerases and DNA-bound proteins. ARC DECRA fellowship (DE150100091),                                                 $366,000

Undergraduate Teaching

Human Perspectives (SGDE)

Honours in Biochemistry (research grant proposal and thesis assessment)

Laboratory placement supervision

2017: Grace Tulysewski

2016: Emi Schutz, Daniel Reed

2015: Alejandra Isabel

2014: Trang Pham, Jade Foeng, Andrew J. Hayes, Queenie Tangseefa, Dominique Jackson

2013: Jia Quyen Truong‎, Byron Shue

2012: Duncan McKenzie

2011: Benjamin Lee (exchange student from Singapore)

2010: Lauren A. Watkins

Undergraduate practical demonstrating

2010 semester 2          Level II MBS Practical series B

2010 semester 1          Level III Biochemistry course

2010 semester 1          Level II MBS Practical series A

2010 semester 1          Level II MBS Practical series C

2009 semester 2          Level II MBS Practical series B

2009 semester 1          Level III Biochemistry course

2009 semester 1          Level II MBS Practical series A

2008 semester 2          Level II MBS Practical series B

2008 semester 1          Level III Biochemistry course

HDR Supervision

Alana Donnelly (PhD) - Co-supervisor

Anthony Lai (Mphil) - Co-supervisor

Masters of Biotechnology 

Hannah Bonham (2017) - Co-supervisor

Wentao Zhang (2014) - Co-supervisor, SMBS prize for top Masters Biotech student

Honours

Kate Tepper (2013) - Co-supervisor, First Class

 

Memberships

Date Role Membership Country
2016 - ongoing Member Synthetic Biology Australasia (SBA) Australia
2010 - ongoing Member Australian Society for Biochemistry and Molecular Biology (ASBMB) Australia
Position
Synthetic Biology Future Science Fellow
Phone
83135362
Fax
8313 4362
Campus
North Terrace
Building
Molecular Life Sciences
Room Number
2 41
Org Unit
Molecular and Cellular Biology

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