Dr Nan Hao
My research interest lies in the broad fields of Synthetic Biology with the aim to combine biochemical studies with mathematical modeling to better understand the “design” features of the genome. This knowledge will inform the design of next generation synthetic platforms for biotechnology and bioremediation.
I am a Synthetic Biology Future Science Fellow based in the School of Biological Sciences. My research aims to advance fundamental knowledge and addresses widespread but poorly understood processes in gene transcription such as transcriptional interference, transcriptional roadblocking, feedback control and DNA looping, all of which are likely to be highly significant for regulation of gene expression. In addition, one important aspect of my research is to apply mathematical thinking to understand the ‘design’ features of the genome.
|2017||Synthetic Biology Future Science Fellow (Level B)||University of Adelaide and CSIRO joint appointment|
|2017 - 2017||ARC DECRA Fellow (Level B)||University of Adelaide, Adelaide|
|2015 - 2016||ARC DECRA Fellow (Level A)||University of Adelaide, Adelaide|
|2012 - 2014||Postdoc Research Fellow (Level A)||University of Adelaide, Adelaide|
|2007 - 2008||Research Assistant||University of Adelaide, Adelaide|
|2006 - 2007||Research Assistant||University of Adelaide, Adelaide|
|2017||Achievement||Finalist||ASBMB Adelaide Protein Group (APG) ECR Award|
|2017||Invitation||Invited Seminar Presentation||Epigenetics Consortium of South Australia and Adelaide RNA Special Interest Group Seminar|
|2017||Invitation||Invited Pitch||US Department of Defence Representative|
|2016||Award||Best presentation/poster in the ECR category||OCE Cutting Edge Conference in Synthetic Biology||A$ 200|
|2015||Invitation||Invited Speaker||School of Biological Sciences Inaugural Research Day|
|2015||Fellowship||ASBMB travel fellowship||ASBMB||A$ 3000|
|2012||Award||Poster Award||ASBMB ComBio conference||A$ 200|
|2012||Research Award||Postgraduate Academic Achievement Award||The University of Adelaide||A$ 500|
|2012||Award||Writing up Award||The University of Adelaide||A$ 3000|
|2011||Award||Poster prize||ASBMB Adelaide Protein Group||A$ 200|
|2011||Award||Chinese government award for outstanding self-financed students abroad||China Scholarship Council||US$ 6000|
|2010||Achievement||Finalist||ASBMB Adelaide Protein Group Student Event|
|2008||Scholarship||Adelaide Graduate Fee Scholarship - PhD scholarship||The University of Adelaide|
|2007||Award||The Brian & Heather Forster Prize in Biochemistry - Top Honours||The University of Adelaide|
|2005||Scholarship||Summer Vacation Scholarship||The University of Adelaide|
|Chinese (Mandarin)||Can read, write, speak, understand spoken and peer review|
|English||Can read, write, speak, understand spoken and peer review|
|2008 - 2012||The University of Adelaide||Australia||PhD in Biochemistry|
|2007 - 2007||The University of Adelaide||Australia||B. Sc. (Honours, First class)|
|2004 - 2006||The University of Adelaide||Australia||B. Sc. (Biomedical Science)|
|2015 - 2015||2nd International Summer School on Synthetic and Systems Biology||University of Catania||Italy|
|2017||Hao, N., Shearwin, K. & Dodd, I. (2017). Programmable DNA looping using engineered bivalent dCas9 complexes. Nature Communications, 8, 1, -.
|2017||Hao, N., Sneppen, K., Shearwin, K. & Dodd, I. (2017). Efficient chromosomal-scale DNA looping in Escherichia coli using multiple DNA-looping elements. Nucleic Acids Research, 45, 9, 5074-5085.
|2017||Hao, N. & Shearwin, K. (2017). Hidden Secrets of Sigma54 Promoters Revealed. Trends in Biochemical Sciences, 42, 12, 931-932.
|2017||Hao, N., Palmer, A., Dodd, I. & Shearwin, K. (2017). Directing traffic on DNA - How transcription factors relieve or induce transcriptional interference. Transcription, 8, 2, 120-125.
|2016||Hao, N., Palmer, A., Ahlgren-Berg, A., Shearwin, K. & Dodd, I. (2016). The role of repressor kinetics in relief of transcriptional interference between convergent promoters. Nucleic Acids Research, 44, 14, 6625-6638.
|2016||Silginer, M., Burghardt, I., Gramatzki, D., Bunse, L., Leske, H., Rushing, E. ... Roth, P. (2016). The aryl hydrocarbon receptor links integrin signaling to the TGF-β pathway. Oncogene, 35, 25, 3260-3271.
|2014||Hao, N., Krishna, S., Ahlgren-Berg, A., Cutts, E., Shearwin, K. & Dodd, I. (2014). Road rules for traffic on DNA - systematic analysis of transcriptional roadblocking in vivo. Nucleic Acids Research, 42, 14, 8861-8872.
|2013||Hao, N. & Whitelaw, M. (2013). The emerging roles of AhR in physiology and immunity. Biochemical Pharmacology, 86, 5, 561-570.
|2013||Hao, N., Bhakti, V., Peet, D. & Whitelaw, M. (2013). Reciprocal regulation of the basic helix-loop-helix/Per-Arnt-Sim partner proteins, Arnt and Arnt2, during neuronal differentiation. Nucleic Acids Research, 41, 11, 5626-5638.
|2012||Hao, N., Lee, K., Furness, S., Bosdotter, C., Poellinger, L. & Whitelaw, M. (2012). Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signaling. Molecular Pharmacology, 82, 6, 1082-1093.
|2011||Hao, N., Whitelaw, M. L., Shearwin, K. E., Dodd, I. B. & Chapman-Smith, A. (2011). Identification of residues in the N-terminal PAS domains important for dimerization of Arnt and AhR. Nucleic Acids Research, 39, 9, 3695-3709.
|2010||Whelan, F., Hao, N., Furness, S., Whitelaw, M. & Chapman-Smith, A. (2010). Amino acid substitutions in the aryl hydrocarbon receptor ligand binding domain reveal YH439 as an atypical AhR activator. Molecular Pharmacology, 77, 6, 1037-1046.
|2017||Hao, N., Shearwin, K. E. & Dodd, I. (2017). Understanding and Manipulating Chromosomal-Scale DNA Looping in Escherichia coli. Synthetic Biology: Engineering, Evolution & Design (SEED). Vancouver, Canada.|
|2017||Hao, N. (2017). Programmable DNA looping using engineered bivalent dCas9 complexes. ASBMB ComBio conference. Adelaide.|
|2017||Hao, N. (2017). Programmable DNA looping using engineered bivalent dCas9 complexes. Synthetic Biology Australasia Conference. Sydney.|
|2017||Hao, N., Priest, D., Dodd, I. & Shearwin, K. (2017). Programmable DNA looping in vivo. Australia-China Symposium on Synthetic Biology. Brisbane.|
|2016||Hao, N., Shearwin, K. & Dodd, I. (2016). Understand DNA looping in vivo - a synthetic biology approach. OCE Cutting Edge Conference in Synthetic Biology. Canberra.|
|2016||Hao, N., Shearwin, K. & Dodd, I. (2016). Road Rules for Traffic on DNA: Gene Regulation by Encounters between Transcribing RNA Polymerases and DNA-bound Proteins. Synthetic Biology: Engineering, Evolution & Design (SEED). Chicago, USA.|
|2015||Hao, N., Krishna, S., Shearwin, K. & Dodd, I. (2015). Road Rules for Traffic on DNA: Gene Regulation by Encounters between Transcribing RNA Polymerases and DNA-bound Proteins. 2nd International Synthetic & Systems Biology Summer School. Taormina - Sicily, Italy.|
|2015||Hao, N. (2015). Understanding and manipulating long-range DNA looping in vivo. ASBMB ComBio conference. Melbourne.|
|2014||Hao, N. (2014). Road Rules for Traffic on DNA: Gene Regulation by Encounters between Transcribing RNA Polymerases and DNA-bound Proteins. The 13th Asian Conference on Transcription. Melbourne.|
|2012||Hao, N., Shearwin, K., Dodd, I., Whitelaw, M. & Chapman-Smith, A. (2012). Reverse Bacterial Two Hybrid: A New Tool for Studying Dimeric Protein Interactions. ASBMB ComBio conference. Adelaide.|
|2009||Hao, N., Shearwin, , Dodd, I., Whitelaw, M. & Chapman-Smith, A. (2009). Reverse Bacterial two Hybrid (RevB2H) method for studying protein-protein interactions. Network in Genes and Environment in Development (NGED) Forum. Palm Cove, Queensland.|
|2009||Hao, N., Shearwin, K., Dodd, I., Whitelaw, M. & Chapman-smith, A. (2009). A novel Reverse Bacterial two Hybrid (RevB2H) method for studying protein-protein interactions and screening for potential therapeutics. Australian Society for Medical Research (ASMR) SA Scientific Meeting. Adelaide.|
|2012||Hao, N.; (2012); Regulation of Eukaryotic Transcription by bHLH/PAS Transcription Factors AhR and Arnt;|
|2007||Hao, N.; (2007); Searching for HIF-1α/Arnt PAS Domain Interacting Proteins;|
|2015||Hao, N.; (2015); Science Under the Volcano - Australian Biochemist Magazine;|
2018-2019 Dr. Nan Hao, A/Prof. Keith Shearwin, Dr. Carol Hartley, Dr. Lawrence Lee and Dr. Colin Scott, Nanomachine v2.0. CSIRO SynBio FSP Pitch Award, $10,000
2017-2020 Dr. Nan Hao, Developing orthogonal Cas/anti-Cas pairs as building blocks for genetic circuit design. CSIRO Future Science Fellowship in Synthetic Biology, $505,000
2018-2018 Dr. Mark Tizard, Dr. Caitlin Cooper, Dr. Brendan Kidd, Dr. Nan Hao, Prof. Rob Capon, Logic Gate Control for Biodiversity Protection. CSIRO SynBio FSP Pitch Award, $10,000
2016-2018 Dr. Ian Dodd, A/Prof. Keith Shearwin, Prof. Kim Sneppen, and Dr. Nan Hao, Understanding and manipulating long-range DNA looping in gene regulation. NHMRC project grant (APP1100651), $351,025
2015-2017 Dr. Nan Hao, Traffic on DNA: interplay between RNA polymerases and DNA-bound proteins. ARC DECRA fellowship (DE150100091), $366,000
Human Perspectives (SGDE)
Honours in Biochemistry (research grant proposal and thesis assessment)
Laboratory placement supervision
2017: Grace Tulysewski
2016: Emi Schutz, Daniel Reed
2015: Alejandra Isabel
2014: Trang Pham, Jade Foeng, Andrew J. Hayes, Queenie Tangseefa, Dominique Jackson
2013: Jia Quyen Truong, Byron Shue
2012: Duncan McKenzie
2011: Benjamin Lee (exchange student from Singapore)
2010: Lauren A. Watkins
Undergraduate practical demonstrating
2010 semester 2 Level II MBS Practical series B
2010 semester 1 Level III Biochemistry course
2010 semester 1 Level II MBS Practical series A
2010 semester 1 Level II MBS Practical series C
2009 semester 2 Level II MBS Practical series B
2009 semester 1 Level III Biochemistry course
2009 semester 1 Level II MBS Practical series A
2008 semester 2 Level II MBS Practical series B
2008 semester 1 Level III Biochemistry course
Alana Donnelly (PhD) - Co-supervisor
Anthony Lai (Mphil) - Co-supervisor
Masters of Biotechnology
Hannah Bonham (2017) - Co-supervisor
Wentao Zhang (2014) - Co-supervisor, SMBS prize for top Masters Biotech student
Kate Tepper (2013) - Co-supervisor, First Class
|2016 - ongoing||Member||Synthetic Biology Australasia (SBA)||Australia|
|2010 - ongoing||Member||Australian Society for Biochemistry and Molecular Biology (ASBMB)||Australia|